methylphenidate has been researched along with Chemical Dependence in 360 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Case reports of five patients suffering from either skin abscesses or cellulitis following parenteral methylphenidate abuse are presented." | 7.65 | Abscess formation as a complication of parenteral methylphenidate abuse. ( Elenbaas, RM; McNabney, WK; Waeckerie, JF, 1976) |
| "Intravenous (IV) drug abuse is known to cause pulmonary tale granulomatosis." | 5.27 | Severe precocious emphysema in intravenous methylphenidate (Ritalin) abusers. ( Hudson, LD; Pierson, DJ; Sherman, CB, 1987) |
| "Medication with methylphenidate should be avoided in patients with vulnerability to schizophrenia and in drug addiction, but reported cases without these risk factors demonstrate that a careful and regular psychiatric monitoring is essential in all patients treated with methylphenidate." | 4.86 | Methylphenidate-induced psychosis in adult attention-deficit/hyperactivity disorder: report of 3 new cases and review of the literature. ( Kis, B; Kraemer, M; Uekermann, J; Wiltfang, J, 2010) |
| "Literature review using a National Library of Medicine database search for 1975 through March 1997 on the terms attention deficit disorder with hyperactivity, methylphenidate, stimulants, and stimulant abuse and dependence." | 4.80 | Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association. ( Bezman, RJ; Genel, M; Goldman, LS; Slanetz, PJ, 1998) |
| "We describe a case of pulmonary granulomatosis in a user who habitually injected methylphenidate (Ritalin) intravenously; symptomatic and objective improvement occurred with corticosteroid therapy." | 3.66 | 67Gallium scanning in talc-induced pulmonary granulomatosis. ( Aguirre, A; Brown, DG; Weaver, A, 1980) |
| "A 28-year-old woman with a long history of drug abuse experienced flaccid quadriplegia and bilateral loss of posterior column sensation a few minutes after an intravenous (IV) injection of methylphenidate hydrochloride." | 3.66 | Medial medullary syndrome in a drug abuser. ( Gonatas, NK; Lewis, RA; Mizutani, T, 1980) |
| "Case reports of five patients suffering from either skin abscesses or cellulitis following parenteral methylphenidate abuse are presented." | 3.65 | Abscess formation as a complication of parenteral methylphenidate abuse. ( Elenbaas, RM; McNabney, WK; Waeckerie, JF, 1976) |
| "There was no difference in days of substance use or ADHD symptom outcomes over time in adolescents with MDD or those without MDD treated with OROS-MPH or placebo." | 2.77 | Major depression and treatment response in adolescents with ADHD and substance use disorder. ( Mikulich-Gilbertson, SK; Min, SJ; Riggs, PD; Tamm, L; Trello-Rishel, K; Warden, D; Winhusen, T, 2012) |
| " However, repeat dosing has not been examined." | 2.77 | Importance of pharmacokinetic profile and timing of coadministration of short- and long-acting formulations of methylphenidate on patterns of subjective responses and abuse potential. ( Batchelder, H; Biederman, J; Clarke, A; Faraone, SV; Martin, JM; Mirto, T; Moorehead, TM; Spencer, TJ, 2012) |
| "Psychostimulants are effective treatments for attention-deficit/hyperactivity disorder (ADHD) but may be associated with euphoric effects, misuse/diversion, and adverse effects." | 2.76 | Subjective effects, misuse, and adverse effects of osmotic-release methylphenidate treatment in adolescent substance abusers with attention-deficit/hyperactivity disorder. ( Adler, LA; Davies, RD; Lewis, DF; Riggs, PD; Somoza, EC; Sonne, S; Winhusen, TM, 2011) |
| "Differences in substance use were revealed in favor of the UCPP, with more adolescents in the CU group smoking cigarettes in the last month (UCPP 17%, CU 42%; chi2 = 4." | 2.73 | Preventive effects of treatment of disruptive behavior disorder in middle childhood on substance use and delinquent behavior. ( Lochman, JE; Matthys, W; van de Wiel, NMH; Zonnevylle-Bender, MJS, 2007) |
| "Methylphenidate has potential for abuse because it produces behavioural effects similar to those observed with other abused stimulants, such as d-amphetamine and cocaine." | 2.71 | Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans. ( Fillmore, MT; Glaser, PE; Rush, CR; Stoops, WW, 2004) |
| "Modafinil is a unique wake-promoting agent." | 2.69 | An evaluation of the abuse potential of modafinil using methylphenidate as a reference. ( Jasinski, DR, 2000) |
| " Deviations from suggested routes of administration such as crushing, chewing, intravenous administration, or snorting stimulant medication may alter the release rate, absorption, and bioavailability of the active drug." | 2.53 | Safety and efficacy considerations due to misuse of extended-release formulations of stimulant medications. ( Jain, R; Stark, JG, 2016) |
| "Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD)." | 2.53 | From Clinical Application to Cognitive Enhancement: The Example of Methylphenidate. ( Busardò, FP; Cipolloni, L; Frati, P; Kyriakou, C; Zaami, S, 2016) |
| "ADHD is often comorbid with substance use disorder (SUD), with Odds Ratio ranges from 1." | 2.52 | Methylphenidate in Adults with Attention Deficit Hyperactivity Disorder and Substance Use Disorders. ( Karila, L; Rolland, B; Simon, N, 2015) |
| " While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs." | 2.49 | Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013) |
| "Comorbid psychiatric disorders should be addressed with disorder-specific therapies while associated symptoms also often improve with treatment of the ADHD core symptoms." | 2.49 | [Adult attention deficit/hyperactivity disorder, associated symptoms and comorbid psychiatric disorders: diagnosis and pharmacological treatment]. ( Alm, B; Paslakis, G; Schredl, M; Sobanski, E, 2013) |
| "Clinical (presence of co-morbid substance use disorders [SUD]) and methodological (design and rater) covariates were also collected, in addition to clinical trial reporting quality." | 2.47 | Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis. ( Bosch, R; Casas, M; Castells, X; Nogueira, M; Ramos-Quiroga, JA; Rigau, D; Vidal, X, 2011) |
| " They are generally safe in special populations." | 2.45 | Safety of stimulant treatment in attention deficit hyperactivity disorder: Part I. ( Kuchibhatla, A; Merkel, RL, 2009) |
| "d-Amphetamine has a mechanism independent of neuronal firing rate, displacing intraneuronal stores of catecholamines, delaying their reuptake and inhibiting catabolism by monoamine oxidase." | 2.45 | The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety. ( Cheetham, SC; Heal, DJ; Smith, SL, 2009) |
| " There is little information on the long-term safety of methylphenidate in adults, although the number of serious adverse effects reported to regulatory authorities has, so far, been low." | 2.45 | Safety of therapeutic methylphenidate in adults: a systematic review of the evidence. ( Godfrey, J, 2009) |
| "Psychotherapy is still the mainstay of treatment; however, relapse rates are high." | 2.44 | Pharmacotherapy of methamphetamine addiction: an update. ( Elkashef, A; Hanson, G; Tiihonen, J; Vocci, F; White, J; Wickes, W, 2008) |
| "Adolescents tend to have shorter substance use histories therefore they often experience emergency/acute care health treatment resulting from substance use related trauma and/or overdose." | 2.43 | Adolescent substance use: brief interventions by emergency care providers. ( Burke, PJ; O'Sullivan, J; Vaughan, BL, 2005) |
| "Methylphenidate, the most common treatment for attention deficit hyperactivity disorder (ADHD), increases extracellular dopamine in the brain, which is associated with its reinforcing as well as its therapeutic effects." | 2.42 | Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. ( Swanson, JM; Volkow, ND, 2003) |
| "When used to treat children with Attention Deficit Hyperactivity Disorder, methylphenidate (MPH) acts primarily by blocking the dopamine (DA) transporter (DAT) and increasing extracellular DA in the striatum." | 2.42 | Serum and brain concentrations of methylphenidate: implications for use and abuse. ( Swanson, JM; Volkow, ND, 2003) |
| "Obesity is a major public health problem." | 2.41 | The role of dopamine in motivation for food in humans: implications for obesity. ( Fowler, JS; Volkow, ND; Wang, GJ, 2002) |
| "However, current substance abuse precludes use of the drug and former abuse liability and social adjustment problems are relative contraindications." | 2.40 | [Central nervous system stimulants and their potential risk of abuse in hyperkinetic disorders]. ( Aanonsen, NO, 1999) |
| "Evaluations for ADHD and substance abuse were completed." | 2.39 | The dual diagnosis of attention-deficit/hyperactivity disorder and substance abuse: case reports and literature review. ( Isaacson, JH; Musial, J; Schubiner, H; Tzelepis, A; Warbasse, LH; Zacharek, M, 1995) |
| " We postulate that periodic and frequent stimulation of the dopaminergic system secondary to chronic use of cocaine favors activation of a circuit that involves the orbitofrontal cortex, cingulate gyrus, thalamus and striatum." | 2.39 | Cocaine addiction: hypothesis derived from imaging studies with PET. ( Ding, YS; Fowler, JS; Volkow, ND; Wang, GJ, 1996) |
| "A minority of alcohol abusers develop severe cerebral dysfunction in the form of Wernicke-Korsakoff syndrome." | 2.35 | Chronic cerebral effects of alcohol and drug abuse. ( Grant, I; Mohns, L, 1975) |
| "The Monitor Mental Health and Substance Use (2021) shows that almost one in twenty students has used ADHD medication for non-medical use at least once in the past year." | 1.91 | [ADHD medication to improve academic performance?] ( Bakker, M; van den Berk-Bulsink, MJE; van der Horst, M, 2023) |
| "Methylphenidate is an effective first-line treatment for attention-deficit/hyperactivity disorder (ADHD)." | 1.91 | The Adverse Effects and Nonmedical Use of Methylphenidate Before and After the Outbreak of COVID-19: Machine Learning Analysis. ( Kim, E; Lee, H; Oh, S; Park, S; Purja, S; Shin, H; Yuniar, CT, 2023) |
| "The drug use history and drug abuse motivation scale were collected at admission." | 1.72 | Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder. ( Mao, F; Sun, P; Wang, N; Xu, J; Yuan, TF; Zhang, Y, 2022) |
| "Methylphenidate was the drug used by the highest percentage of the population (2." | 1.72 | [Trend in medicines use for attention deficit hyperactivity disorder in children and adolescents (2010-2019).] ( Alberola López, S; Andrés de Llano, JM; Gutiérrez-Abejón, E; Prieto Antolín, B, 2022) |
| "Methylphenidate (MPH) is a mild CNS stimulant that has been used in hyperactive children, and patients with neurodegenerative and major depressive disorders." | 1.62 | Cannabidiol attenuated the maintenance and reinstatement of extinguished methylphenidate-induced conditioned place preference in rats. ( Haghparast, A; Jamali, S; Kashefi, A; Rashidy-Pour, A; Tomaz, C; Vafaei, AA, 2021) |
| "We evaluated the risk of drug abuse and dependence (DAAD) related to substances that are known to be used for PNE and divided this group into agents with (methylphenidate) and without a known abuse potential outside the field of PNE (atomoxetine, modafinil, acetylcholine esterase inhibitors, and memantine)." | 1.46 | Sensitivity of Quantitative Signal Detection in Regards to Pharmacological Neuroenhancement. ( Connemann, BJ; Gahr, M; Schönfeldt-Lecuona, C; Zeiss, R, 2017) |
| " We here propose analytical methods to disclose acute and chronic use of two types of new psychostimulants: benzofurans and ethylphenidate and we applied them to a real case of a subject attending Emergency Department with signs of acute intoxication due to psychotropic drug(s)." | 1.46 | Intoxication caused by new psychostimulants: analytical methods to disclose acute and chronic use of benzofurans and ethylphenidate. ( Barceló, B; Busardò, FP; Elorza, MÁ; Gomila, I; Kyriakou, C; Marchei, E; Pichini, S; Roset, C; Rotolo, MC, 2017) |
| " Lack of longitudinal follow-up studies of dosing and adverse effects has resulted in conflicting treatment guidelines." | 1.46 | Methylphenidate doses in Attention Deficit/Hyperactivity Disorder and comorbid substance use disorders. ( Brandt, L; D'Onofrio, B; Franck, J; Larsson, H; Skoglund, C, 2017) |
| "The most common comorbidities were substance use disorders (39." | 1.43 | Psychiatric Comorbidity at the Time of Diagnosis in Adults With ADHD: The CAT Study. ( Balanzá-Martínez, V; García-García, P; Piñeiro-Dieguez, B; Soler-López, B, 2016) |
| "Ethylphenidate was specifically mentioned in the cause of death for 5 cases, chronic intravenous (IV) drug use was named as part of the cause of death for 2 cases and in 6 cases there was evidence of complications and infections through IV drug use." | 1.42 | A review of ethylphenidate in deaths in east and west Scotland. ( McKeown, D; Parks, C; Torrance, HJ, 2015) |
| "The association of substance use disorders (SUD) with attention-deficit disorder (ADHD), co-morbid mental disorders, and medication has only been studied in isolation and in rather small samples." | 1.40 | Substance use disorders in association with attention-deficit/hyperactivity disorder, co-morbid mental disorders, and medication in a nationwide sample. ( Bisgaard, C; Steinhausen, HC, 2014) |
| "Diagnoses of SUD and alcohol abuse were obtained from The Danish Psychiatric Central Register." | 1.40 | ADHD, stimulant treatment in childhood and subsequent substance abuse in adulthood - a naturalistic long-term follow-up study. ( Dalsgaard, S; Frydenberg, M; Mortensen, PB; Thomsen, PH, 2014) |
| "Pretreatment with methylphenidate (0." | 1.37 | Comparison of the effects of methamphetamine, bupropion, and methylphenidate on the self-administration of methamphetamine by rhesus monkeys. ( Gilman, JP; Goldberg, SR; McCann, DJ; Panlilio, LV; Schindler, CW, 2011) |
| "A history of multiple substance use may be a risk factor for non-medical use of methylphenidate." | 1.37 | Severe toxicity due to injected but not oral or nasal abuse of methylphenidate tablets. ( Bodmer, M; Bruggisser, M; Liechti, ME, 2011) |
| "Methylphenidate is a psychostimulant drug indicated for the treatment of attention-deficit hyperactivity disorder (ADHD)." | 1.37 | Patterns of methylphenidate use and assessment of its abuse and diversion in two French administrative areas using a proxy of deviant behaviour determined from a reimbursement database: main trends from 2005 to 2008. ( Coudert, H; Frauger, E; Micallef, J; Natali, F; Pauly, V; Pradel, V; Reggio, P; Thirion, X, 2011) |
| "However, it has been demonstrated that drug addiction is associated with dopaminergic system changes that may affect MPH brain effects, emphasizing the need to better understand MPH actions in subjects with ADHD+SUD." | 1.35 | Methylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study. ( Bressan, RA; Fu, YK; Hoexter, MQ; Júnior, N; Pechansky, F; Rohde, LA; Schaefer, T; Shih, MC; Szobot, CM, 2008) |
| "Even when controlling for substance use disorder, age at stimulant treatment initiation was significantly and positively related to the later development of antisocial personality disorder." | 1.35 | Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. ( Castellanos, FX; Howell, KH; Klein, RG; Mannuzza, S; Moulton, JL; Roizen, ER; Truong, NL, 2008) |
| "Drug ID and drug abuse calls were assessed by call year and geographic location." | 1.33 | Methylphenidate abuse in Texas, 1998-2004. ( Forrester, MB, 2006) |
| "This new drug abuse prevention paradigm holds great promise for efforts to reduce the nonmedical use of prescription controlled substances, including the prescription stimulants used to treat ADHD." | 1.33 | Abuse-resistant drug delivery. ( Bensinger, PB; DuPont, RL, 2006) |
| "Methylphenidate (MPH) is a prescription stimulant drug with known abuse potential; however, little is known about its patterns of misuse or the characteristics of its abusers." | 1.33 | Characteristics of methylphenidate misuse in a university student sample. ( Barrett, SP; Bordy, LE; Darredeau, C; Pihl, RO, 2005) |
| "Methylphenidate is a central nervous system stimulant used for the treatment of attention deficit hyperactivity disorder and narcolepsy and like other psychostimulants has a potential for abuse." | 1.32 | Lacunar stroke associated with methylphenidate abuse. ( Sadeghian, H, 2004) |
| "Pretreatment with methylphenidate decreased binding only in striatum (40%)." | 1.29 | Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. ( Ashby, C; Dewey, S; Ding, YS; Fowler, JS; Gatley, JS; Hitzemann, R; Liebermann, J; Logan, J; Volkow, ND; Wang, GJ, 1995) |
| " Antidepressant medications, both TCAs and MAOIs, often help relieve the symptoms of depression that emerge when chronic use of cocaine is discontinued." | 1.27 | Cocaine abuse and its treatment. ( Resnick, EB; Resnick, RB, 1984) |
| "The granulomas are associated with a history of intravenous injection of medications (Ritalin and Talwin) intended for oral use." | 1.27 | Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse. ( Edland, JF; Lundquest, DE; Young, WK, 1987) |
| "Intravenous (IV) drug abuse is known to cause pulmonary tale granulomatosis." | 1.27 | Severe precocious emphysema in intravenous methylphenidate (Ritalin) abusers. ( Hudson, LD; Pierson, DJ; Sherman, CB, 1987) |
| "Bereavement after diagnosing AIDS or other HIV disease, psychological symptoms secondary to brain disease and the social consequences of having AIDS all interact to produce a devastating illness where the patient may be intensely grieving, demented and totally rejected by all of society." | 1.27 | Psychosocial aspects of AIDS. ( Goldmeier, D, 1987) |
| " Dose-response differences were also revealed in "breaking point" comparisons between secobarbital on the one hand, and methylphenidate and cocaine, on the other." | 1.26 | Behavioral procedures for evaluating the relative abuse potential of CNS drugs in primates. ( Brady, JV; Griffiths, RR, 1976) |
| " Dosage should be titrated individually for each patient, and it is best to start with small doses given at least 15 to 30 minutes before meals." | 1.26 | Methylphenidate: a review. ( Majovski, LV; Oettinger, L, 1976) |
| "Thirty adolescents with histories of minimal brain dysfunction who had been treated for at least six months with chemotherapy were compared with 30 adolescents who had not been so treated." | 1.25 | Childhood chemotherapy and later drug abuse and growth curve: a follow-up study of 30 adolescents. ( Beck, L; Langford, WS; Mackay, M; Sum, G, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 112 (31.11) | 18.7374 |
| 1990's | 23 (6.39) | 18.2507 |
| 2000's | 99 (27.50) | 29.6817 |
| 2010's | 110 (30.56) | 24.3611 |
| 2020's | 16 (4.44) | 2.80 |
| Authors | Studies |
|---|---|
| Arvidsson, M | 2 |
| Franck, J | 5 |
| Ackehed, G | 1 |
| Pettersson Bergstrand, M | 1 |
| Ekström, L | 1 |
| Rosenborg, S | 1 |
| Dahl, ML | 2 |
| Prieto Antolín, B | 1 |
| Gutiérrez-Abejón, E | 1 |
| Alberola López, S | 1 |
| Andrés de Llano, JM | 1 |
| Elgueta-Reyes, M | 1 |
| Velásquez, VB | 1 |
| Espinosa, P | 1 |
| Riquelme, R | 1 |
| Dib, T | 1 |
| Sanguinetti, NK | 1 |
| Escobar, AP | 1 |
| Martínez-Pinto, J | 1 |
| Renard, GM | 1 |
| Sotomayor-Zárate, R | 1 |
| Xu, J | 1 |
| Zhang, Y | 1 |
| Wang, N | 1 |
| Sun, P | 1 |
| Mao, F | 1 |
| Yuan, TF | 1 |
| van den Berk-Bulsink, MJE | 1 |
| Bakker, M | 1 |
| van der Horst, M | 1 |
| Tschudi, L | 1 |
| Fischer, SKM | 1 |
| Perlov, E | 1 |
| Baumgartner, MR | 1 |
| Soyka, M | 1 |
| Müller, TJ | 1 |
| Seifritz, E | 1 |
| Mutschler, J | 1 |
| Shin, H | 1 |
| Yuniar, CT | 1 |
| Oh, S | 1 |
| Purja, S | 1 |
| Park, S | 1 |
| Lee, H | 1 |
| Kim, E | 1 |
| Shoff, EN | 1 |
| Kahl, JH | 1 |
| Hime, GW | 1 |
| Coburn, M | 1 |
| Boland, DM | 1 |
| de Oliveira Cata Preta, B | 1 |
| Miranda, VIA | 1 |
| Bertoldi, AD | 1 |
| Tardelli, VS | 1 |
| Bisaga, A | 1 |
| Arcadepani, FB | 1 |
| Gerra, G | 1 |
| Levin, FR | 3 |
| Fidalgo, TM | 1 |
| Shellenberg, TP | 1 |
| Stoops, WW | 2 |
| Lile, JA | 1 |
| Rush, CR | 4 |
| Ponnet, K | 1 |
| Tholen, R | 1 |
| De Bruyn, S | 1 |
| Wouters, E | 1 |
| Van Ouytsel, J | 1 |
| Walrave, M | 1 |
| Van Hal, G | 1 |
| Kashefi, A | 1 |
| Tomaz, C | 1 |
| Jamali, S | 1 |
| Rashidy-Pour, A | 1 |
| Vafaei, AA | 1 |
| Haghparast, A | 1 |
| Miranda, M | 1 |
| Barbosa, M | 1 |
| Cunill, R | 1 |
| Castells, X | 2 |
| González-Pinto, A | 1 |
| Arrojo, M | 1 |
| Bernardo, M | 1 |
| Sáiz, PA | 1 |
| Flórez, G | 1 |
| Torrens, M | 1 |
| Tirado-Muñoz, J | 1 |
| Fonseca, F | 1 |
| Arranz, B | 1 |
| Garriga, M | 1 |
| Goikolea, JM | 1 |
| Zorrilla, I | 1 |
| Becoña, E | 1 |
| López, A | 1 |
| San, L | 1 |
| Zhang, R | 1 |
| Manza, P | 1 |
| Tomasi, D | 1 |
| Kim, SW | 1 |
| Shokri-Kojori, E | 1 |
| Demiral, SB | 1 |
| Kroll, DS | 1 |
| Feldman, DE | 1 |
| McPherson, KL | 1 |
| Biesecker, CL | 1 |
| Wang, GJ | 12 |
| Volkow, ND | 16 |
| Moore, TJ | 1 |
| Wirtz, PW | 1 |
| Kruszewski, SP | 1 |
| Alexander, GC | 1 |
| Schrantee, A | 1 |
| Bouziane, C | 1 |
| Bron, EE | 1 |
| Klein, S | 1 |
| Bottelier, MA | 1 |
| Kooij, JJS | 1 |
| Rombouts, SARB | 1 |
| Reneman, L | 1 |
| Barceló, B | 1 |
| Gomila, I | 1 |
| Rotolo, MC | 1 |
| Marchei, E | 1 |
| Kyriakou, C | 2 |
| Pichini, S | 1 |
| Roset, C | 1 |
| Elorza, MÁ | 1 |
| Busardò, FP | 2 |
| Skoglund, C | 2 |
| Brandt, L | 2 |
| D'Onofrio, B | 1 |
| Larsson, H | 2 |
| Abelman, DD | 1 |
| Iglseder, B | 1 |
| Crunelle, CL | 2 |
| van den Brink, W | 1 |
| Moggi, F | 1 |
| Konstenius, M | 2 |
| van de Glind, G | 1 |
| Demetrovics, Z | 1 |
| Coetzee, C | 1 |
| Luderer, M | 1 |
| Schellekens, A | 1 |
| Matthys, F | 1 |
| Jang, M | 1 |
| Kim, J | 1 |
| Shin, I | 1 |
| Kang, S | 1 |
| Choi, H | 1 |
| Yang, W | 1 |
| Wiig, EH | 1 |
| Nielsen, NP | 1 |
| Korn, L | 1 |
| Hassan, K | 1 |
| Fainshtein, N | 1 |
| Yusov, N | 1 |
| Davidovitch, N | 1 |
| Adorjan, K | 1 |
| Karch, S | 1 |
| Martin, G | 1 |
| Plörer, D | 1 |
| Winter, C | 1 |
| Hantschk, I | 1 |
| Koller, G | 1 |
| Erbas, B | 1 |
| Pogarell, O | 1 |
| Scholz, I | 1 |
| Schmid, Y | 1 |
| Exadaktylos, AK | 1 |
| Haschke, M | 1 |
| Liechti, ME | 3 |
| Liakoni, E | 1 |
| Yadav-Samudrala, BJ | 1 |
| Eltit, JM | 1 |
| Glennon, RA | 1 |
| Dela Peña, I | 1 |
| Kim, BN | 1 |
| Han, DH | 1 |
| Kim, Y | 1 |
| Cheong, JH | 1 |
| Looby, A | 3 |
| De Young, KP | 1 |
| Earleywine, M | 3 |
| Dubljević, V | 2 |
| Sandberg, A | 2 |
| Hall, W | 2 |
| Partridge, B | 1 |
| Lucke, J | 1 |
| Levy, N | 1 |
| Greely, HT | 1 |
| Forlini, C | 1 |
| Racine, E | 1 |
| Vollmann, J | 1 |
| Schildmann, J | 1 |
| LaBuzetta, JN | 1 |
| Brewer, CD | 1 |
| DeGrote, H | 1 |
| Faulmüller, N | 1 |
| Maslen, H | 1 |
| de Sio, FS | 1 |
| Flanigan, J | 1 |
| van der Eijk, Y | 1 |
| Savulescu, J | 1 |
| Paslakis, G | 1 |
| Schredl, M | 1 |
| Alm, B | 1 |
| Sobanski, E | 1 |
| Cassidy, TA | 2 |
| McNaughton, EC | 1 |
| Varughese, S | 3 |
| Russo, L | 2 |
| Zulueta, M | 1 |
| Butler, SF | 2 |
| Dalsgaard, S | 1 |
| Mortensen, PB | 1 |
| Frydenberg, M | 1 |
| Thomsen, PH | 1 |
| Spada, MM | 1 |
| van Emmerik-van Oortmerssen, K | 1 |
| Carpentier, PJ | 2 |
| Steinhausen, HC | 1 |
| Bisgaard, C | 1 |
| Lapeyre-Mestre, M | 1 |
| Gony, M | 1 |
| Carvajal, A | 1 |
| Macias, D | 1 |
| Conforti, A | 1 |
| D'Incau, P | 1 |
| Heerdink, R | 1 |
| Van der Stichele, R | 1 |
| Bergman, U | 1 |
| Piñeiro-Dieguez, B | 1 |
| Balanzá-Martínez, V | 1 |
| García-García, P | 1 |
| Soler-López, B | 1 |
| Hildt, E | 3 |
| Lieb, K | 3 |
| Franke, AG | 3 |
| Calipari, ES | 1 |
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| Rockwell, DA | 1 |
| AtLee, WE | 1 |
| Allgén, LG | 1 |
| Bergsman, A | 1 |
| Hellström, L | 1 |
| Tec, L | 1 |
| Ladewig, D | 1 |
| Battegay, R | 1 |
| Fischer, KC | 1 |
| Wilson, WP | 1 |
| Hopkins, GB | 1 |
| Taylor, DG | 1 |
| Rapp, MS | 1 |
| Perman, ES | 1 |
| Koschmann, EB | 1 |
| Sigell, LT | 1 |
| Flessa, HC | 1 |
| Willey, RF | 1 |
| Rozberg, G | 1 |
| Sugar, HS | 1 |
| Mandell, GH | 1 |
| Shalev, J | 1 |
| Harbauer, H | 1 |
| Jersild, T | 1 |
| Ott, C | 1 |
| Thiede, J | 1 |
| Milner, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Brain Dopaminergic Signaling in Opioid Use Disorders (OUD)[NCT03190954] | Early Phase 1 | 300 participants (Anticipated) | Interventional | 2017-08-17 | Recruiting | ||
| Assessing Cognitive Performance Among Adults With Attention Disorders Working on Treadmill[NCT05243186] | Phase 2/Phase 3 | 30 participants (Anticipated) | Interventional | 2021-10-01 | Recruiting | ||
| The Effects of Methylphenidate (MPH) and Non-invasive Brain Stimulation (tDCS) on Inhibitory Control Children With Attention-Deficit/Hyperactivity Disorder (ADHD)[NCT04964427] | 26 participants (Actual) | Interventional | 2021-02-08 | Completed | |||
| Investigating the Efficacy of Cognitive Behavioral Therapy in Patients With Substance Use Disorder and Comorbid ADHD. A Randomized Controlled Trial With Cognitive Behavioral Therapy[NCT01431235] | 184 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS-MPH) for Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)[NCT00264797] | Phase 3 | 303 participants (Actual) | Interventional | 2006-02-28 | Completed | ||
| A Single Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate Efficacy of PR OROS Methylphenidate Followed by Open-Label Extension, in Swedish Male Prison Inmates With ADHD[NCT00482313] | Phase 3 | 30 participants (Actual) | Interventional | 2007-05-31 | Completed | ||
| Methylphenidate Transdermal System (MTS) in the Treatment of Adult ADHD[NCT00506285] | Phase 3 | 92 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Implications of Tamarkoz® on Reducing Stress and Heart Rate, and Increasing Positive Emotions, Spirituality[NCT03489148] | 103 participants (Actual) | Interventional | 2015-08-24 | Completed | |||
| A Double-blind, Randomized, Placebo-controlled, Crossover Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults[NCT00302458] | Phase 4 | 44 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323] | 80 participants (Anticipated) | Interventional | 2023-06-01 | Recruiting | |||
| Efficacy of Cognitive Behavioral Therapy in Treatment of Adults With Attention Deficit Hyperactivity Disorder[NCT02210728] | 200 participants (Anticipated) | Interventional | 2006-04-30 | Active, not recruiting | |||
| Brain Activation in Response to Motivational and Affective Stimuli: Pharmacological Manipulations[NCT00047866] | 38 participants (Actual) | Observational | 2002-10-12 | Completed | |||
| A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102] | Phase 4 | 105 participants (Actual) | Interventional | 2016-02-29 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
DSM IV ADHD Rating Scale (ADHD-RS) adolescent informant, ascertained at baseline and weekly throughout the 16 week study. This scale is an 18-item symptom checklist of self-reported adolescent ADHD symptoms. Symptoms are scored as None (0), Mild (1), Moderate (2), and Severe (3), with a summary total of scores for the 18 symptoms. Possible scores range from 0 to 54, with higher scores indicating greater severity. Outcome is measured as the decrease in total severity score over time. (NCT00264797)
Timeframe: baseline and 20 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Methylphenidate | -20.6 |
| Methylphenidate (Placebo) | -21.8 |
Assessed by pill counts in conjunction with weekly review of subjects' medication diaries and self-reported medication compliance. (NCT00264797)
Timeframe: 20 weeks
| Intervention | pills (Mean) |
|---|---|
| Methylphenidate | 15.4 |
| Methylphenidate (Placebo) | 9.7 |
The change in number of days of substance use from baseline to end of the trial. The number of days of non-tobacco drug/alcohol ascertained using standard timeline follow back (TLFB) procedures. (NCT00264797)
Timeframe: 20 weeks
| Intervention | days (Mean) |
|---|---|
| Methylphenidate | -5.7 |
| Methylphenidate (Placebo) | -5.2 |
The mean number of negative urine drug screens (UDS). (NCT00264797)
Timeframe: 20 weeks
| Intervention | negative UDS (Mean) |
|---|---|
| Methylphenidate | 3.8 |
| Methylphenidate (Placebo) | 2.8 |
Measures the DSM based ADHD criteria of Inattention and Hyperactivity/Impulsivity. There are 30 items scored 0-3 for a minimum score of 0 (no symptoms) and a maximum score of 90 worst possible symptoms. (NCT00506285)
Timeframe: Double-blind endpoints for MTS and placebo arms
| Intervention | units on a scale (Mean) |
|---|---|
| Scores in MTS Arm | 30.8 |
| Scores in Placebo Arm | 49.5 |
This scale measures the 7 domains of the Utah Criteria for Adult ADHD. Total scores run from 0 to 28. Normative samples average below 5. The worst possible score is 28. (NCT00506285)
Timeframe: Double-blind endpoints during MTS and placebo arms
| Intervention | units on a scale (Mean) |
|---|---|
| Scores in MTS Arm | 11.0 |
| Scores in Placebo Arm | 17.9 |
Objective measure determined from blood samples, measured 4 hours after the dose (NCT00302458)
Timeframe: 4 hours
| Intervention | mg/L (Mean) |
|---|---|
| Placebo- Placebo | 0.00 |
| IR-MPH + OROS MPH | 15.06 |
| IR-MPH +IR-MPH | 25.34 |
| OROS-MPH+OROS-MPH | 20.34 |
| OROS-MPH+ IR-MPH | 28.79 |
Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Placebo | 53.5 |
| Modafinil | 61.0 |
Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -5.67 |
| Modafinil | -8.91 |
76 reviews available for methylphenidate and Chemical Dependence
| Article | Year |
|---|---|
Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.
Topics: Amphetamine; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Humans; Lisdexamfetami | 2020 |
An update on the clinical pharmacology of methylphenidate: therapeutic efficacy, abuse potential and future considerations.
Topics: Abuse-Deterrent Formulations; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2020 |
Clinical practice guideline on pharmacological and psychological management of adult patients with attention deficit and hyperactivity disorder and comorbid substance use.
Topics: Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys | 2022 |
Mitigating risks of students use of study drugs through understanding motivations for use and applying harm reduction theory: a literature review.
Topics: Academic Success; Adolescent; Adult; Amphetamines; Central Nervous System Stimulants; Dexmethylpheni | 2017 |
[Doping for the brain].
Topics: Aged; Amphetamines; Brain; Cognitive Aging; Dietary Supplements; Humans; Illicit Drugs; Methylphenid | 2018 |
[Adult attention deficit hyperactivity disorder (ADHD) with comorbid addictive disorder. Therapeutic challenges using the example of a survey of clinical practice].
Topics: Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys | 2019 |
Abuse and dependence liability analysis of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder (ADHD): what have we learned?
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Addictive; Behavior, Animal; Blood | 2013 |
[Adult attention deficit/hyperactivity disorder, associated symptoms and comorbid psychiatric disorders: diagnosis and pharmacological treatment].
Topics: Adult; Anxiety; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Co | 2013 |
An overview of problematic internet use.
Topics: Antidepressive Agents, Second-Generation; Behavior, Addictive; Central Nervous System Stimulants; Ci | 2014 |
[Substance use disorders and ADHD: an overview of recent Dutch research].
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity; Human | 2013 |
The potential for misuse and abuse of medications in ADHD: a review.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; A | 2014 |
Methylphenidate in Adults with Attention Deficit Hyperactivity Disorder and Substance Use Disorders.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity | 2015 |
[Methylphenidate].
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; J | 2015 |
Are there any potentially dangerous pharmacological effects of combining ADHD medication with alcohol and drugs of abuse? A systematic review of the literature.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Alcohol Drinking; Atomoxetine Hydrochloride; Attention Def | 2015 |
From Clinical Application to Cognitive Enhancement: The Example of Methylphenidate.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognition | 2016 |
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits.
Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dopamine; Humans; Methamp | 2016 |
Generation Z: Adolescent Xenobiotic Abuse in the 21st Century.
Topics: Adolescent; Amphetamine-Related Disorders; Cannabinoids; Central Nervous System Stimulants; Designer | 2015 |
Safety and efficacy considerations due to misuse of extended-release formulations of stimulant medications.
Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Dosag | 2016 |
Safety of therapeutic methylphenidate in adults: a systematic review of the evidence.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Evidence-Ba | 2009 |
Pharmacotherapy of methamphetamine addiction: an update.
Topics: Antipsychotic Agents; Aripiprazole; Bupropion; Central Nervous System Stimulants; Dextroamphetamine; | 2008 |
Attention-deficit-hyperactivity disorder: an update.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Amphetamine; Antidepressive Agents, Second-Generati | 2009 |
Illicit methylphenidate use: a review of prevalence, availability, pharmacology, and consequences.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Prescriptions | 2009 |
The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety.
Topics: Adrenergic Uptake Inhibitors; Amphetamine; Animals; Atomoxetine Hydrochloride; Attention Deficit Dis | 2009 |
Safety of stimulant treatment in attention deficit hyperactivity disorder: Part I.
Topics: Adolescent; Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste | 2009 |
Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies.
Topics: Animals; Behavior Therapy; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Clini | 2010 |
Methylphenidate-induced psychosis in adult attention-deficit/hyperactivity disorder: report of 3 new cases and review of the literature.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous System Stimu | 2010 |
[Methylphenidate: pharmacology, indication and potential of abuse].
Topics: Adult; Attention Deficit and Disruptive Behavior Disorders; Humans; Male; Methylphenidate; Narcoleps | 2010 |
Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Delayed-Action Preparations; Diag | 2011 |
Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Delayed-Action Preparations; Diag | 2011 |
Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Delayed-Action Preparations; Diag | 2011 |
Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Delayed-Action Preparations; Diag | 2011 |
[Methylphenidate misuse].
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Sectional St | 2012 |
Comorbid attention deficit/hyperactivity disorder and substance use disorder: treatment considerations.
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste | 2012 |
Pharmacological and clinical dilemmas of prescribing in co-morbid adult attention-deficit/hyperactivity disorder and addiction.
Topics: Adrenergic Uptake Inhibitors; Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hype | 2014 |
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure | 2013 |
The role of dopamine in motivation for food in humans: implications for obesity.
Topics: Animals; Appetite; Brain Chemistry; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonis | 2002 |
Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Dopamine; Dopamine Plasma Membrane Tr | 2002 |
Methylphenidate and substance abuse: a review of pharmacology, animal, and clinical studies.
Topics: Administration, Oral; Animals; Central Nervous System Stimulants; Child; Humans; Longitudinal Studie | 2002 |
Attention deficit hyperactivity disorder in sport: a review.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clinical Trials as | 2003 |
Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient.
Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimula | 2003 |
Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD.
Topics: Attention Deficit Disorder with Hyperactivity; Brain; Cocaine; Delayed-Action Preparations; Dopamine | 2003 |
Serum and brain concentrations of methylphenidate: implications for use and abuse.
Topics: Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Brain; Brain Chemis | 2003 |
Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects.
Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Behavior; Brain Injuries; Central Ner | 2004 |
When the child with ADHD grows up.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2004 |
Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules.
Topics: Aging; Animals; Behavior; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Chil | 2004 |
Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M | 2005 |
Adolescent substance use: brief interventions by emergency care providers.
Topics: Adolescent; Adolescent Behavior; Attention Deficit Disorder with Hyperactivity; Chest Pain; Cocaine- | 2005 |
Misuse of "study drugs:" prevalence, consequences, and implications for policy.
Topics: Adolescent; Adult; Amphetamines; Cardiovascular Diseases; Central Nervous System Stimulants; Emotion | 2006 |
The science of stimulant abuse.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; De | 2006 |
Nonmedical use of prescription stimulants among students.
Topics: Adolescent; Adult; Central Nervous System Stimulants; Child; Female; Humans; Male; Methylphenidate; | 2006 |
Attention deficit hyperactivity disorder across the lifespan: the child, adolescent, and adult.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; | 2007 |
The consequences of attention-deficit/hyperactivity disorder in adults.
Topics: Achievement; Adult; Age Factors; Amphetamine; Atomoxetine Hydrochloride; Attention Deficit Disorder | 2007 |
Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature.
Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst | 2008 |
ADHD, substance use disorders, and psychostimulant treatment: current literature and treatment guidelines.
Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child | 2008 |
Attention deficit hyperactivity disorder and substance use disorders.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Bupropion; Central Nervous System Stimula | 2008 |
Cardiac and vascular involvement in drug abuse.
Topics: Adult; Aneurysm, Infected; Arterial Occlusive Diseases; Arteriovenous Fistula; Cardiomyopathies; Car | 1983 |
The spectrum of cocaine abuse and its treatment.
Topics: Ambulatory Care; Antidepressive Agents, Tricyclic; Behavior Therapy; Cocaine; Depressive Disorder; H | 1984 |
Cocaine abuse: a review of current and experimental treatments.
Topics: Animals; Antidepressive Agents, Tricyclic; Cocaine; Humans; Lithium; Lithium Carbonate; Methylphenid | 1984 |
The dual diagnosis of attention-deficit/hyperactivity disorder and substance abuse: case reports and literature review.
Topics: Adult; Alcoholism; Attention Deficit Disorder with Hyperactivity; Comorbidity; Diagnosis, Dual (Psyc | 1995 |
Cocaine addiction: hypothesis derived from imaging studies with PET.
Topics: Animals; Brain; Carbon Radioisotopes; Cocaine; Dopamine Uptake Inhibitors; Humans; Methylphenidate; | 1996 |
Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association.
Topics: Adolescent; American Medical Association; Attention Deficit Disorder with Hyperactivity; Central Ner | 1998 |
[Central nervous system stimulants and their potential risk of abuse in hyperkinetic disorders].
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dext | 1999 |
Emerging drugs of abuse in Connecticut.
Topics: Cannabis; Connecticut; Female; Humans; Incidence; Ketamine; Male; Methylphenidate; Risk Assessment; | 2000 |
Psychostimulants in supportive care.
Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Dextroamphetamine; Ephedrine; Humans; Men | 2000 |
Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review.
Topics: Animals; Dopamine Uptake Inhibitors; Humans; Methylphenidate; Substance-Related Disorders | 2001 |
Attention deficit hyperactivity disorder and substance use disorders: Is there a causal link?
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste | 2001 |
Abuse and toxicity of methylphenidate.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2002 |
Hyperkinetic children: the use of stimulant drugs evaluated.
Topics: Achievement; Animals; Attention; Blood Pressure; Central Nervous System; Dextroamphetamine; Feeding | 1975 |
[Psychotropic drug therapy in children].
Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; | 1977 |
Effects of psychostimulants on aggression.
Topics: Adolescent; Aggression; Amphetamine; Animals; Child; Dextroamphetamine; Dogs; Dose-Response Relation | 1975 |
Chronic cerebral effects of alcohol and drug abuse.
Topics: Alcoholism; Amphetamines; Barbiturates; Brain Diseases; Cannabis; Cerebrovascular Disorders; Cocaine | 1975 |
Addictiveness of central stimulants.
Topics: Amphetamines; Central Nervous System Stimulants; Cocaine; Euphoria; Humans; Methylphenidate; Substan | 1990 |
Disseminated granulomatosis through a patent foramen ovale in an intravenous drug user with pulmonary hypertension.
Topics: Adult; Heart Septum; Humans; Hydromorphone; Hypertension, Pulmonary; Lymphomatoid Granulomatosis; Ma | 1987 |
Substance abuse in adolescents: diagnostic issues derived from studies of attention deficit disorder with hyperactivity.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Humans; Male; Methylphenidate; Pro | 1988 |
Chronic neuropharmacology of cocaine: progress in pharmacotherapy.
Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Dopamine; Humans; Methylphenidate; Psychotherapy; R | 1988 |
Myocardial injury associated with polysubstance abuse.
Topics: Adult; Amphetamine; Cardiomyopathies; Cocaine; Drug Synergism; Electrocardiography; Female; Heroin; | 1988 |
Treating problem children with stimulant drugs.
Topics: Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants | 1973 |
Eikenella corrodens, a recently recognized pathogen: infections in medical-surgical patients and in association with methylphenidate abuse.
Topics: Abscess; Adolescent; Adult; Aged; Ampicillin; Bacteriological Techniques; Bacteroides; Bacteroides I | 1974 |
Genetic issues in the syndrome of minimal brain dysfunction.
Topics: Attention Deficit Disorder with Hyperactivity; Dextroamphetamine; Diseases in Twins; Female; Humans; | 1973 |
32 trials available for methylphenidate and Chemical Dependence
| Article | Year |
|---|---|
Challenging expectancies to prevent nonmedical prescription stimulant use: a randomized, controlled trial.
Topics: Adolescent; Alcoholism; Central Nervous System Stimulants; Data Interpretation, Statistical; Female; | 2013 |
An N-of-1 trial as an individualized withdrawal treatment approach to psychological methylphenidate dependence.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Over | 2014 |
An application of analyzing the trajectories of two disorders: A parallel piecewise growth model of substance use and attention-deficit/hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognit | 2015 |
Assessment of human abuse potential of dasotraline compared to methylphenidate and placebo in recreational stimulant users.
Topics: 1-Naphthylamine; Adult; Central Nervous System Stimulants; Cross-Over Studies; Dose-Response Relatio | 2016 |
Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD).
Topics: Administration, Oral; Adult; Area Under Curve; Attention Deficit Disorder with Hyperactivity; Centra | 2009 |
Molecular imaging genetics of methylphenidate response in ADHD and substance use comorbidity.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Brain; Brain Mapping; Comorbidity; Dopami | 2011 |
Cigarette and cannabis use trajectories among adolescents in treatment for attention-deficit/hyperactivity disorder and substance use disorders.
Topics: Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys | 2011 |
Randomized controlled trial of osmotic-release methylphenidate with cognitive-behavioral therapy in adolescents with attention-deficit/hyperactivity disorder and substance use disorders.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognit | 2011 |
Major depression and treatment response in adolescents with ADHD and substance use disorder.
Topics: Adolescent; Alcohol-Related Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervou | 2012 |
Subjective effects, misuse, and adverse effects of osmotic-release methylphenidate treatment in adolescent substance abusers with attention-deficit/hyperactivity disorder.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2011 |
Methylphenidate treatment of adult male prison inmates with attention-deficit hyperactivity disorder: randomised double-blind placebo-controlled trial with open-label extension.
Topics: Adult; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous System S | 2012 |
Oppositional defiant disorder in adults with ADHD.
Topics: Adult; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperact | 2013 |
Importance of pharmacokinetic profile and timing of coadministration of short- and long-acting formulations of methylphenidate on patterns of subjective responses and abuse potential.
Topics: Adolescent; Adult; Attitude; Central Nervous System Stimulants; Cross-Over Studies; Delayed-Action P | 2012 |
Predictors of treatment response in adolescents with comorbid substance use disorder and attention-deficit/hyperactivity disorder.
Topics: Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; C | 2013 |
Do Stimulants Reduce the Risk for Alcohol and Substance Use in Youth With ADHD? A Secondary Analysis of a Prospective, 24-Month Open-Label Study of Osmotic-Release Methylphenidate.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 2017 |
Effects of methylphenidate on impulsive choice in adult humans.
Topics: Adolescent; Adult; Analysis of Variance; Central Nervous System Stimulants; Choice Behavior; Humans; | 2003 |
Does stimulant treatment place children at risk for adult substance abuse? A controlled, prospective follow-up study.
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste | 2003 |
Assessing methylphenidate preference in ADHD patients using a choice procedure.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2004 |
Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans.
Topics: Adult; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationship, Drug; Doubl | 2004 |
A controlled trial of methylphenidate in adults with attention deficit/hyperactivity disorder and substance use disorders.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Over | 2005 |
Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects.
Topics: Adult; Blood Pressure; Brain; Brain Chemistry; Central Nervous System Stimulants; Dopamine; Dopamine | 2006 |
Preventive effects of treatment of disruptive behavior disorder in middle childhood on substance use and delinquent behavior.
Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Central Nervous System Stimulants; | 2007 |
Do formulation differences alter abuse liability of methylphenidate? A placebo-controlled, randomized, double-blind, crossover study in recreational drug users.
Topics: Adult; Behavior, Addictive; Central Nervous System Stimulants; Cross-Over Studies; Delayed-Action Pr | 2007 |
Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humans.
Topics: Administration, Oral; Adolescent; Adult; Amphetamine; Area Under Curve; Central Nervous System Stimu | 2007 |
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2008 |
Abuse liability assessment of atomoxetine in a drug-abusing population.
Topics: Adrenergic Uptake Inhibitors; Adult; Arousal; Atomoxetine Hydrochloride; Central Nervous System Stim | 2008 |
Methylphenidate effects on symptoms of attention deficit disorder in adults.
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Clinical Trial | 1984 |
Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers: a pilot study.
Topics: Adult; Attention; Central Nervous System Stimulants; Cognition Disorders; Delayed-Action Preparation | 1997 |
An evaluation of the abuse potential of modafinil using methylphenidate as a reference.
Topics: Adult; Appetite; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Cross-Over Studie | 2000 |
Comparison of the subjective, physiological, and psychomotor effects of atomoxetine and methylphenidate in light drug users.
Topics: Adolescent; Adult; Analysis of Variance; Atomoxetine Hydrochloride; Blood Pressure; Double-Blind Met | 2002 |
The effect of methylphenidate on serum growth hormone: influence of antipsychotic drugs and diagnosis.
Topics: Adjustment Disorders; Adolescent; Adult; Alcoholism; Antipsychotic Agents; Bipolar Disorder; Blood P | 1978 |
Diagnosis and treatment of minimal brain dysfunction in adults: a preliminary report.
Topics: Adult; Alcoholism; Antisocial Personality Disorder; Anxiety; Attention Deficit Disorder with Hyperac | 1976 |
252 other studies available for methylphenidate and Chemical Dependence
| Article | Year |
|---|---|
Plasma concentrations of methylphenidate enantiomers in adults with ADHD and substance use disorder, with focus on high doses and relationship to carboxylesterase activity.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Carboxylic Ester Hydrolases; Central Nervous S | 2022 |
[Trend in medicines use for attention deficit hyperactivity disorder in children and adolescents (2010-2019).]
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2022 |
Effects of Early Life Exposure to Sex Hormones on Neurochemical and Behavioral Responses to Psychostimulants in Adulthood: Implications in Drug Addiction.
Topics: Amphetamine; Animals; Central Nervous System Stimulants; Dopamine; Estradiol; Female; Male; Methylph | 2022 |
Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans | 2022 |
[ADHD medication to improve academic performance?]
Topics: Academic Performance; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2023 |
Concomitant Drug Use among Opioid-Dependent Patients with and without Attention Deficit Hyperactivity Disorder: Does Methylphenidate Merit a Trial?
Topics: Amphetamine; Analgesics, Opioid; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst | 2023 |
The Adverse Effects and Nonmedical Use of Methylphenidate Before and After the Outbreak of COVID-19: Machine Learning Analysis.
Topics: Attention Deficit Disorder with Hyperactivity; Bayes Theorem; Central Nervous System Stimulants; COV | 2023 |
4-Fluoromethylphenidate: Fatal Intoxication Involving a Previously Unreported Novel Psychoactive Substance in the USA.
Topics: Adult; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Fatal Outcome; Foren | 2019 |
Psychostimulant Use for Neuroenhancement (Smart Drugs) among College Students in Brazil.
Topics: Brazil; Central Nervous System Stimulants; Cognition; Cross-Sectional Studies; Humans; Methylphenida | 2020 |
Students' stimulant use for cognitive enhancement: A deliberate choice rather than an emotional response to a given situation.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognition; | 2021 |
Cannabidiol attenuated the maintenance and reinstatement of extinguished methylphenidate-induced conditioned place preference in rats.
Topics: Animals; Cannabidiol; Central Nervous System Stimulants; Conditioning, Psychological; Extinction, Ps | 2021 |
Use of Cognitive Enhancers by Portuguese Medical Students: Do Academic Challenges Matter?
Topics: Central Nervous System Stimulants; Humans; Methylphenidate; Nootropic Agents; Portugal; Students, Me | 2022 |
Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward.
Topics: Actigraphy; Adult; Central Nervous System Stimulants; Circadian Rhythm; Corpus Striatum; Female; Hum | 2021 |
Changes in medical use of central nervous system stimulants among US adults, 2013 and 2018: a cross-sectional study.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Secti | 2021 |
Long-term effects of stimulant exposure on cerebral blood flow response to methylphenidate and behavior in attention-deficit hyperactivity disorder.
Topics: Adult; Affect; Age Factors; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous Sy | 2018 |
Intoxication caused by new psychostimulants: analytical methods to disclose acute and chronic use of benzofurans and ethylphenidate.
Topics: Benzofurans; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hair; Human | 2017 |
Methylphenidate doses in Attention Deficit/Hyperactivity Disorder and comorbid substance use disorders.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2017 |
International Consensus Statement on Screening, Diagnosis and Treatment of Substance Use Disorder Patients with Comorbid Attention Deficit/Hyperactivity Disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity | 2018 |
Simultaneous determination of methylphenidate and ritalinic acid in hair using LC-MS/MS.
Topics: Central Nervous System Stimulants; Chromatography, Liquid; Hair; Humans; Limit of Detection; Methylp | 2019 |
Methylphenidate effects on processing speed in a clinical sample of adults with ADHD and substance use disorder: a pilot study.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2019 |
Non-Medical Use of Prescription Stimulants for Treatment of Attention Disorders by University Students: Characteristics and Associations.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognition D | 2019 |
Emergency department presentations related to abuse of prescription and over-the-counter drugs in Switzerland: time trends, sex and age distribution.
Topics: Adolescent; Adult; Age Distribution; Aged; Alcohol Drinking; Antidepressive Agents; Benzodiazepines; | 2019 |
Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors.
Topics: Alkaloids; Central Nervous System Stimulants; Dopamine Plasma Membrane Transport Proteins; Dopamine | 2019 |
Methylphenidate: abuse in Europe.
Topics: Central Nervous System Stimulants; Europe; Humans; Methylphenidate; Substance-Related Disorders | 2013 |
Prohibition or coffee shops: regulation of amphetamine and methylphenidate for enhancement use by healthy adults.
Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Central Nervous System Stimulants; Cognition | 2013 |
Enhancement policy and the value of information.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
Constraints on regulatory options for putatively cognitive enhancing drugs.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
There may be costs to failing to enhance, as well as to enhancing.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
Some first steps toward responsible use of cognitive-enhancing drugs by the healthy.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
How research on stakeholder perspectives can inform policy on cognitive enhancement.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
Moving beyond methylphenidate and amphetamine: the ethics of a better "smart drug".
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
Regulating methylphenidate: enhancing cognition and social inequality.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
The indirect psychological costs of cognitive enhancement.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
An argument for permitting amphetamines and instant-release methylphenidate.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
Tobacco: prohibition, coffee shops, or discouragement?
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
A liberal consequentialist approach to regulation of cognitive enhancers.
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2013 |
Nonmedical use of prescription ADHD stimulant medications among adults in a substance abuse treatment population: early findings from the NAVIPPRO surveillance system.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Attention Deficit Disorder with Hyperactivity; Cen | 2015 |
ADHD, stimulant treatment in childhood and subsequent substance abuse in adulthood - a naturalistic long-term follow-up study.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Attention Deficit Disorder with Hyperactivity; Central N | 2014 |
Substance use disorders in association with attention-deficit/hyperactivity disorder, co-morbid mental disorders, and medication in a nationwide sample.
Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Attention Deficit Disorder with Hype | 2014 |
Response to open peer commentaries on "prohibition or coffee shops: regulation of amphetamine and methylphenidate for enhancement use by healthy adults".
Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate; | 2014 |
A European community pharmacy-based survey to investigate patterns of prescription fraud through identification of falsified prescriptions.
Topics: Analgesics, Opioid; Belgium; Benzodiazepines; Buprenorphine; Central Nervous System Stimulants; Cros | 2014 |
Psychiatric Comorbidity at the Time of Diagnosis in Adults With ADHD: The CAT Study.
Topics: Adult; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Comorbidity; Cross-Sectiona | 2016 |
Life context of pharmacological academic performance enhancement among university students--a qualitative approach.
Topics: Adult; Amphetamines; Central Nervous System Stimulants; Cognition; Educational Status; Female; Human | 2014 |
Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration.
Topics: Amphetamine; Animals; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response | 2014 |
Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products.
Topics: Alkaloids; Cannabinoids; Central Nervous System Stimulants; Designer Drugs; Heterocyclic Compounds, | 2014 |
Methylphenidate misuse in adult patients and the impact of therapeutic use.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Data Interp | 2015 |
Intravenous methylphenidate: an unusual way to provoke ST-elevation myocardial infarction.
Topics: Adult; Central Nervous System Stimulants; Electrocardiography; Emergency Service, Hospital; Heart; H | 2015 |
Injection of crushed tablets--a prospective observational study.
Topics: Adolescent; Adult; Azabicyclo Compounds; Benzodiazepines; Buprenorphine; C-Reactive Protein; Female; | 2014 |
Intention and willingness in understanding Ritalin misuse among Iranian medical college students: a cross-sectional study.
Topics: Cross-Sectional Studies; Drug Users; Female; Humans; Intention; Iran; Male; Methylphenidate; Student | 2014 |
Prevalence, Patient Characteristics, and Pharmacological Treatment of Children, Adolescents, and Adults Diagnosed With ADHD in Sweden.
Topics: Adolescent; Adult; Age Distribution; Anxiety Disorders; Attention Deficit Disorder with Hyperactivit | 2018 |
Everyday drug diversions: a qualitative study of the illicit exchange and non-medical use of prescription stimulants on a university campus.
Topics: Adolescent; Amphetamines; Central Nervous System Stimulants; Deception; Drug Trafficking; Female; Hu | 2015 |
Differences in methylphenidate abuse rates among methadone maintenance treatment patients in two clinics.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Central Nervous System Stimul | 2015 |
Differences in abuse potential of ADHD drugs measured by contrasting poison centre and therapeutic use data.
Topics: Adolescent; Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central | 2015 |
Nopaine no gain: recreational ethylphenidate toxicity.
Topics: Adult; Anxiety; Arrhythmias, Cardiac; Central Nervous System; Central Nervous System Stimulants; Chr | 2015 |
Patterns of concurrent substance use among adolescent nonmedical ADHD stimulant users.
Topics: Adolescent; Amphetamines; Analgesics, Opioid; Central Nervous System Stimulants; Child; Cocaine-Rela | 2015 |
Dependence on Internet-Purchased Ethylphenidate.
Topics: Humans; Internet; Male; Methylphenidate; Substance-Related Disorders; Young Adult | 2015 |
Reflections on Addiction in Students Using Stimulants for Neuroenhancement: A Preliminary Interview Study.
Topics: Adult; Amphetamines; Behavior, Addictive; Central Nervous System Stimulants; Female; Health Surveys; | 2015 |
Prevalence of cognitive enhancer use among New Zealand tertiary students.
Topics: Adult; Amphetamines; Benzhydryl Compounds; Female; Humans; Male; Methylphenidate; Modafinil; Motivat | 2016 |
A review of ethylphenidate in deaths in east and west Scotland.
Topics: Adult; Cause of Death; Central Nervous System Stimulants; Female; Humans; Male; Methylphenidate; Mid | 2015 |
Smart drugs: A dose of intelligence.
Topics: Aging; Amphetamines; Animals; Benzhydryl Compounds; Biomedical Enhancement; Caffeine; Child; Cogniti | 2016 |
ADHD and psychostimulants - overdiagnosis and overprescription.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Overdose; Fem | 2016 |
ADHD medication overdose and misuse: the NSW Poisons Information Centre experience, 2004-2014.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2016 |
Factors Associated With Adherence to Methylphenidate Treatment in Adult Patients With Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2016 |
Involvement of AMPA/kainate and GABAA receptors in topiramate neuroprotective effects against methylphenidate abuse sequels involving oxidative stress and inflammation in rat isolated hippocampus.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fructose; Glutathione Disulfide | 2016 |
The Genetic and Environmental Association Between Parental Monitoring and Risk of Cannabis, Stimulants, and Cocaine Initiation in a Sample of Male Twins: Does Parenting Matter?
Topics: Adolescent; Adult; Child; Cocaine-Related Disorders; Humans; Male; Marijuana Abuse; Methylphenidate; | 2016 |
Imitations and Transformations: On Side Effects of the ADHD Epidemic.
Topics: Adult; Anthropology, Medical; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 2017 |
Assessing prescription drug abuse using functional principal component analysis (FPCA) of wastewater data.
Topics: Environmental Monitoring; Humans; Methadone; Methylphenidate; Models, Theoretical; Norway; Oxazepam; | 2017 |
Sensitivity of Quantitative Signal Detection in Regards to Pharmacological Neuroenhancement.
Topics: Adrenergic Uptake Inhibitors; Adverse Drug Reaction Reporting Systems; Atomoxetine Hydrochloride; Au | 2017 |
Increasing use of stimulants warns of potential abuse.
Topics: Adult; Amphetamine; Central Nervous System Stimulants; Drug Prescriptions; Humans; Methylphenidate; | 2008 |
Impulsive choice and environmental enrichment: effects of d-amphetamine and methylphenidate.
Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Choice Behavior; Conditio | 2008 |
Abuse of medications employed for the treatment of ADHD: results from a large-scale community survey.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Data C | 2008 |
NICE guidance on ADHD. Diversion and abuse of methylphenidate in light of new guidance.
Topics: Adult; Central Nervous System Stimulants; Child; Drug Prescriptions; Humans; Methylphenidate; Practi | 2008 |
Nicotinic receptors differentially modulate the induction and expression of behavioral sensitization to methylphenidate in rats.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Dihydro-beta-Erythroidine; Dose-Respon | 2009 |
[Drug dependence and methylphenidate].
Topics: Attention Deficit Disorder with Hyperactivity; Dopamine Uptake Inhibitors; Humans; Methylphenidate; | 2008 |
Juvenile methylphenidate exposure and factors that influence incentive processing.
Topics: Administration, Oral; Aging; Animals; Central Nervous System Stimulants; Conditioning, Operant; Fema | 2009 |
Case histories in pharmaceutical risk management.
Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Dextroamphetamine; Drug and Narcotic Contro | 2009 |
Prescription stimulant expectancies in recreational and medical users: results from a preliminary expectancy questionnaire.
Topics: Adolescent; Adult; Amphetamines; Central Nervous System; Cluster Analysis; Female; Humans; Internet; | 2009 |
Central stimulants in the treatment of attention-deficit hyperactivity disorder (ADHD) in children and adolescents. A naturalistic study of the prescription in Sweden, 1977-2007.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Amphetamine; Attention Deficit Disorder with Hy | 2009 |
Methods of recruiting adolescents with psychiatric and substance use disorders for a clinical trial.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Clinical Trials as Topic; Cognitive Behav | 2009 |
[Bipolar disorders as co-morbidity in childhood and adolescence--underdiagnosed or overinterpreted? Therapy of a 14-year-old boy with hyperkinetic conduct disorder and hypomania].
Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; A | 2010 |
Dispositional, ecological and biological influences on adolescent tranquilizer, Ritalin, and narcotics misuse.
Topics: Adolescent; Child; Dopamine Uptake Inhibitors; Female; Humans; Male; Methylphenidate; Opioid-Related | 2011 |
Illicit methylphenidate use among Iranian medical students: prevalence and knowledge.
Topics: Adolescent; Adult; Age Factors; Central Nervous System Stimulants; Female; Health Knowledge, Attitud | 2011 |
Comparison of the effects of methamphetamine, bupropion, and methylphenidate on the self-administration of methamphetamine by rhesus monkeys.
Topics: Animals; Bupropion; Central Nervous System Stimulants; Conditioning, Operant; Dopamine Uptake Inhibi | 2011 |
The nonmedical use of prescription stimulants among dental and dental hygiene students.
Topics: Adolescent; Adult; Amphetamines; Attention; Attention Deficit Disorder with Hyperactivity; Attitude | 2011 |
Patterns of methylphenidate use and assessment of its abuse and diversion in two French administrative areas using a proxy of deviant behaviour determined from a reimbursement database: main trends from 2005 to 2008.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Attention Deficit Disorder with Hyperactivity; Central N | 2011 |
Characteristics of college students with attention-deficit hyperactivity disorder symptoms who misuse their medications.
Topics: Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Como | 2011 |
Severe toxicity due to injected but not oral or nasal abuse of methylphenidate tablets.
Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Central Nervous System Stimulan | 2011 |
Caveat emptor, venditor, et praescribor: legal liability associated with methyplenidate hydrochloride (MPH) use by postsecondary students.
Topics: Adolescent; Central Nervous System Stimulants; Humans; Liability, Legal; Methylphenidate; Students; | 2010 |
The use of prescription stimulants to enhance academic performance among college students in health care programs.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Amphetamines; Central Nervous System Stimulants; C | 2011 |
[Characteristics of university students using stimulants for cognitive enhancement: a pilot study].
Topics: Adolescent; Adult; Alcoholism; Amphetamines; Case-Control Studies; Central Nervous System Stimulants | 2012 |
[Brain doping. With smart pills becoming the perfect human being].
Topics: Achievement; Adolescent; Adult; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Chil | 2012 |
[Less fast, less far, less often].
Topics: Achievement; Activities of Daily Living; Central Nervous System Stimulants; Doping in Sports; Humans | 2012 |
[Methylphenidate induced ST elevation acute myocardial infarction].
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Coronary Vasospasm | 2012 |
Is the non-medical use of prescription stimulants a problem in Australia?
Topics: Amphetamine-Related Disorders; Australia; Central Nervous System Stimulants; Humans; Methylphenidate | 2012 |
[The medical treatment of attention deficit hyperactivity disorder (ADHD) with amphetamines in children and adolescents].
Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervo | 2012 |
Methylphenidate: abuse and addiction.
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste | 2012 |
Nonmedical Use and Diversion of ADHD Stimulants Among U.S. Adults Ages 18-49: A National Internet Survey.
Topics: Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulant | 2015 |
Attempted abuse of concerta.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Delayed-Action Preparations; Diagnosis, D | 2002 |
An unlikely vice: Ritalin.
Topics: Attention; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; | 2001 |
Oral methylphenidate-alcohol co-abuse.
Topics: Administration, Oral; Adult; Alcoholism; Central Nervous System Stimulants; Comorbidity; Female; Hum | 2002 |
Poison centers' experience with methylphenidate abuse in pre-teens and adolescents.
Topics: Adolescent; Adult; Child; Female; Humans; Hypertension; Male; Methylphenidate; Poison Control Center | 2003 |
[Off-label use: the case of methylphenidate (Ritalin)].
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Labeli | 2002 |
Is there stimulant sensitivity in children?
Topics: Adolescent; Adult; Animals; Arousal; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2002 |
Illicit methylphenidate use in an undergraduate student sample: prevalence and risk factors.
Topics: Alcoholism; Central Nervous System Stimulants; Data Collection; Female; Humans; Illicit Drugs; Inter | 2003 |
Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential.
Topics: Animals; Atomoxetine Hydrochloride; Attention; Caffeine; Cognition; Cognition Disorders; Color Perce | 2003 |
Cognitive enhancement raises ethical concerns. Academics urge pre-emptive debate on neurotechnologies.
Topics: Central Nervous System Stimulants; Cognition; Ethics, Medical; Humans; Methylphenidate; Students; Su | 2003 |
AMBULATORY WITHDRAWAL TREATMENT OF HEROIN ADDICTS.
Topics: Chloral Hydrate; Chlorpromazine; Drug Therapy; Glutethimide; Heroin; Humans; Meprobamate; Methylphen | 1964 |
[Methylphenidylacetate addiction].
Topics: Humans; Methylphenidate; Substance-Related Disorders | 1960 |
Is ritalin an addiction-producing drug?
Topics: Behavior, Addictive; Humans; Methylphenidate; Substance-Related Disorders | 1960 |
[On the abuse of Ritalin].
Topics: Humans; Mental Disorders; Methylphenidate; Substance-Related Disorders | 1961 |
[On the problem of methylphenidylacetate addiction].
Topics: Behavior, Addictive; Humans; Methylphenidate; Substance-Related Disorders | 1961 |
Urinary screening for methylphenidate (Ritalin) abuse: a comparison of liquid chromatography-tandem mass spectrometry, gas chromatography-mass spectrometry, and immunoassay methods.
Topics: Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Hum | 2004 |
Lacunar stroke associated with methylphenidate abuse.
Topics: Adult; Brain Infarction; Humans; Male; Methylphenidate; Substance-Related Disorders | 2004 |
Drug dependence and addiction, III: Expectation and brain function in drug abuse.
Topics: Behavior, Addictive; Brain; Central Nervous System Stimulants; Cocaine-Related Disorders; Glucose; H | 2004 |
An update on attention deficit disorder.
Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Ch | 2004 |
Increased psychotropic drug consumption by children in the Netherlands during 1995-2001 is caused by increased use of methylphenidate by boys.
Topics: Adolescent; Central Nervous System Stimulants; Child; Child, Preschool; Databases, Factual; Female; | 2004 |
Prevalence and characteristics of adolescents patients with co-occurring ADHD and substance dependence.
Topics: Adolescent; Adolescent Behavior; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst | 2004 |
Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys.
Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy | 2005 |
Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey.
Topics: Adult; Amphetamines; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Male; Met | 2005 |
[Caffeine, cannabis and cocaine: from automedication to 'automutilation' in adults with ADHD].
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System Stimulants; C | 2004 |
Treating adolescent girls and women with ADHD: gender-specific issues.
Topics: Adolescent; Adult; Age Factors; Amphetamine; Anxiety Disorders; Attention Deficit Disorder with Hype | 2005 |
Characteristics of methylphenidate misuse in a university student sample.
Topics: Adolescent; Adult; Alcoholism; Attention; Central Nervous System Stimulants; Comorbidity; Cross-Sect | 2005 |
Stimulant medications: how to minimize their reinforcing effects?
Topics: Attention Deficit Disorder with Hyperactivity; Behavior, Addictive; Brain; Central Nervous System St | 2006 |
Methylphenidate abuse in Texas, 1998-2004.
Topics: Adolescent; Adolescent Behavior; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; | 2006 |
Characteristics of methylphenidate dependence syndrome in psychiatric hospital settings.
Topics: Adult; Female; Humans; Male; Methamphetamine; Methylphenidate; Substance-Related Disorders | 2006 |
[Diagnosis and treatment of the attention-deficit/hyperactivity syndrome (ADHS) in adults with drug addiction in in-patient and out-patient setting].
Topics: Adult; Alcoholism; Ambulatory Care; Attention Deficit Disorder with Hyperactivity; Borderline Person | 2006 |
Abuse-resistant drug delivery.
Topics: Administration, Oral; Adolescent; Adult; Central Nervous System Stimulants; Humans; Methylphenidate; | 2006 |
Re: Characteristics of methylphenidate in a university student sample.
Topics: Administration, Intranasal; Attention Deficit Disorder with Hyperactivity; Central Nervous System St | 2006 |
Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration.
Topics: Adolescent; Adult; Amphetamines; Central Nervous System Stimulants; Drug Prescriptions; Female; Heal | 2006 |
Misuse of methamphetamine and prescription stimulants among youths and young adults in the community.
Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Central Nervous System Stimulants; Com | 2007 |
Sensitization and cross-sensitization after chronic treatment with methylphenidate in adolescent Wistar rats.
Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Dose-Respons | 2007 |
From attention-deficit/hyperactivity disorder to medical stimulant use to the diversion of prescribed stimulants to non-medical stimulant use: connecting the dots.
Topics: Adolescent; Amphetamines; Attention Deficit Disorder with Hyperactivity; Canada; Central Nervous Sys | 2007 |
Pleasure and discipline in the uses of Ritalin.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Methylphen | 2008 |
Patterns and predictors of medication compliance, diversion, and misuse in adult prescribed methylphenidate users.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity | 2007 |
Critical assessment of the methylphenidate transdermal system.
Topics: Adhesiveness; Administration, Cutaneous; Adolescent; Attention Deficit Disorder with Hyperactivity; | 2007 |
The nonmedical use of prescription ADHD medications: results from a national Internet panel.
Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Appetite Depressants; Attention Defici | 2007 |
Methylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Chemistry, Pharmaceutical; Data Interpret | 2008 |
Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood.
Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste | 2008 |
Four cases of progressive drug abuse.
Topics: Adult; Alcohols; Amphetamine; Barbiturates; Cannabis; Cocaine; Humans; Lysergic Acid Diethylamide; M | 1967 |
Talc retinopathy.
Topics: Adult; Female; Fluorescein Angiography; Humans; Injections, Intravenous; Male; Methylphenidate; Midd | 1980 |
Ocular findings in the intravenous drug abuser.
Topics: Adult; Embolism; Eye Diseases; Female; Heroin; Humans; Injections, Intravenous; Methylphenidate; Neo | 1982 |
An unusual cause of an indolent skin infection.
Topics: Adult; Bacteroides Infections; Eikenella corrodens; Heroin; Humans; Male; Methylphenidate; Skin Dise | 1983 |
Unacceptable face of private practice: prescription of controlled drugs to addicts.
Topics: Cyclizine; Drug and Narcotic Control; Drug Combinations; Drug Prescriptions; Drug Utilization; Femal | 1983 |
Cocaine abuse and its treatment.
Topics: Antidepressive Agents; Behavior Therapy; Cocaine; Cognition; Conditioning, Psychological; Diazepam; | 1984 |
Methylphenidate (Ritalin) treatment of cocaine dependence--a preliminary report.
Topics: Adult; Cocaine; Female; Humans; Male; Methylphenidate; Substance-Related Disorders; Time Factors | 1984 |
Multiple mycotic pulmonary artery aneurysms secondary to intravenous drug abuse.
Topics: Adult; Aneurysm, Infected; Angiography; Endocarditis, Bacterial; Female; Humans; Injections, Intrave | 1984 |
Stimulant medication and the hyperactive adolescent: myths and facts.
Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Dextroamphetamine; Dose-Respon | 1983 |
Cautionary note on methylphenidate for cocaine dependence.
Topics: Cocaine; Humans; Legislation, Drug; Methylphenidate; Substance-Related Disorders; United States | 1984 |
Hepatic dysfunction due to intravenous abuse of methylphenidate hydrochloride.
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Injections, Intravenous; Liver Functi | 1984 |
Hyperactivity and the attention deficit disorders: expanding frontiers.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Cognition; Cogni | 1984 |
Young adult outcome of hyperactive children who received long-term stimulant treatment.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Child; Employment; Follow-Up Studies; Humans; | 1984 |
The California registration system for habitues to schedule II drugs.
Topics: Barbiturates; California; Chronic Disease; Humans; Methylphenidate; Pain; Registries; Substance-Rela | 1981 |
An extreme case of cocaine dependence and marked improvement with methylphenidate treatment.
Topics: Adult; Cocaine; Female; Humans; Methylphenidate; Self Concept; Self Medication; Substance-Related Di | 1983 |
Ritalin: consequences of abuse in a clinical population.
Topics: Adult; Female; Humans; Injections, Intravenous; Male; Methadone; Methylphenidate; Opioid-Related Dis | 1982 |
Hemiplegia after intracarotid injection of methylphenidate.
Topics: Adult; Carotid Arteries; Female; Hemiplegia; Humans; Injections, Intra-Arterial; Methylphenidate; Su | 1982 |
Intracranial hemorrhage with amphetamine abuse.
Topics: Adult; Cerebral Hemorrhage; Dextroamphetamine; Humans; Male; Methylphenidate; Substance-Related Diso | 1981 |
Case studies in neuropsychiatry: post-traumatic psychiatric dysfunction--diagnosis and treatment.
Topics: Adult; Brain Injuries; Humans; Male; Methylphenidate; Neurocognitive Disorders; Substance-Related Di | 1981 |
Reversible hemiplegia after presumed intracarotid injection of Ritalin.
Topics: Carotid Arteries; Female; Hemiplegia; Humans; Injections, Intra-Arterial; Methylphenidate; Substance | 1981 |
Retinal detachment and vitreous hemorrhage due to talc emboli.
Topics: Adult; Blindness; Embolism; Hemorrhage; Humans; Injections, Intravenous; Male; Methylphenidate; Reti | 1981 |
67Gallium scanning in talc-induced pulmonary granulomatosis.
Topics: Adult; Female; Gallium Radioisotopes; Granuloma; Humans; Hypertension, Pulmonary; Lung Diseases; Met | 1980 |
Medial medullary syndrome in a drug abuser.
Topics: Adult; Brain; Cerebral Infarction; Female; Humans; Injections, Intravenous; Intracranial Embolism an | 1980 |
Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain.
Topics: Adult; Animals; Brain; Carbon Radioisotopes; Cerebellum; Cocaine; Corpus Striatum; Half-Life; Humans | 1995 |
Medication for attention-deficit hyperactivity disorder: balancing art and science.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Agents; Depression | 1996 |
Cognitive event-related potentials in populations at risk for substance abuse.
Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; | 1996 |
Neurochemical mechanisms underlying responses to psychostimulants.
Topics: Animals; Behavior; Brain; Brain Chemistry; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake | 1996 |
Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine.
Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transpo | 1997 |
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects.
Topics: Adult; Behavior, Addictive; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine Uptak | 1997 |
[Attention deficit hyperactivity disorder, facilitating alcohol and drug abuse in an adult].
Topics: Adult; Alcoholism; Attention Deficit Disorder with Hyperactivity; Cannabis; Central Nervous System S | 1997 |
Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates.
Topics: Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane | 1998 |
[Talc pulmonary granulomatosis caused by intravenous administration of methylphenidate].
Topics: Central Nervous System Stimulants; Granuloma, Foreign-Body; Humans; Injections, Intravenous; Lung Di | 1998 |
Intranasal abuse of prescribed methylphenidate.
Topics: Administration, Intranasal; Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervo | 1998 |
Stimulant use and the potential for abuse in Wisconsin as reported by school administrators and longitudinally followed children.
Topics: Administrative Personnel; Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Attitude | 1998 |
Intranasal abuse of prescribed methylphenidate.
Topics: Administration, Intranasal; Adolescent; Central Nervous System Stimulants; Humans; Male; Methylpheni | 1998 |
Practical guidelines for the treatment of substance abusers with adult attention-deficit hyperactivity disorder.
Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System | 1999 |
Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels.
Topics: Adult; Carbon Radioisotopes; Central Nervous System Stimulants; Corpus Striatum; Dopamine Antagonist | 1999 |
Escalating dose-binge treatment with methylphenidate: role of serotonin in the emergent behavioral profile.
Topics: Animals; Central Nervous System Stimulants; Dopamine; Male; Methylphenidate; Motor Activity; Rats; R | 1999 |
Central auditory processing disorder and ADHD.
Topics: Attention Deficit Disorder with Hyperactivity; Audiometry; Auditory Perceptual Disorders; Central Ne | 2000 |
Diurnal differences in sensitization to methylphenidate.
Topics: Animals; Brain; Central Nervous System Stimulants; Circadian Rhythm; Dose-Response Relationship, Dru | 2000 |
Student perceptions of methylphenidate abuse at a public liberal arts college.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Attitude to Health; Data Collection; Female; H | 2000 |
Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers.
Topics: Adult; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Caudate Nucleus; Cerebellum; | 2001 |
Near-fatal methylphenidate misuse.
Topics: Adolescent; Central Nervous System Stimulants; Female; Humans; Methylphenidate; Respiratory Insuffic | 2001 |
Failed attempts at intranasal abuse of Concerta.
Topics: Administration, Intranasal; Adolescent; Attention Deficit Disorder with Hyperactivity; Euphoria; Fem | 2002 |
Use of medication by young people with attention-deficit/hyperactivity disorder.
Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Australia; Central | 2002 |
Disk and peripheral retinal neovascularization secondary to talc and cornstarch emboli.
Topics: Adult; Embolism; Excipients; Humans; Injections, Intravenous; Male; Methylphenidate; Neovascularizat | 1979 |
Methylphenidate (Ritalin) abuse.
Topics: Adult; Granuloma; Humans; Injections, Intravenous; Male; Methylphenidate; Osteomyelitis; Pleural Dis | 1977 |
Talc emboli and macular ischemia in intravenous drug abuse.
Topics: Adult; Embolism; Humans; Injections, Intravenous; Ischemia; Macula Lutea; Male; Methylphenidate; Mic | 1979 |
Abuse of prescribed stimulant medication by a 13-year-old hyperactive boy.
Topics: Adolescent; Humans; Hyperkinesis; Male; Methylphenidate; Substance-Related Disorders | 1979 |
Self-injected retinal emboli.
Topics: Adult; Capillaries; Embolism; Female; Fluorescein Angiography; Humans; Injections, Intravenous; Macu | 1979 |
Eosinophilic syndrome with methylphenidate abuse.
Topics: Adult; Eosinophilia; Female; Humans; Male; Methylphenidate; Middle Aged; Substance-Related Disorders | 1978 |
Necrotizing fasciitis associated with Haemophilus aphrophilus. Report of a case.
Topics: Adult; Anti-Bacterial Agents; Drainage; Fascia; Haemophilus Infections; Humans; Inflammation; Male; | 1978 |
Methylphenidate abuse produces retinopathy.
Topics: Capillaries; Embolism; Humans; Injections, Intravenous; Methylphenidate; Particle Size; Retinal Dise | 1979 |
Behavioral procedures for evaluating the relative abuse potential of CNS drugs in primates.
Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Haplorhini; Humans; Methylphenidate; Papio; Rein | 1976 |
Drug abuse treatment report from Sweden.
Topics: Adult; Amphetamines; Cannabis; Female; Humans; Male; Mental Health Services; Methods; Methylphenidat | 1977 |
Characteristics of unlimited access to self-administered stimulant infusions in dogs.
Topics: Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Dogs; Humans; Infusions, Parent | 1976 |
Abscess formation as a complication of parenteral methylphenidate abuse.
Topics: Abscess; Adult; Cellulitis; Female; Humans; Injections, Intravenous; Male; Methylphenidate; Skin Dis | 1976 |
Intravenous injection of talc-containing drugs intended for oral use. A cause of pulmonary granulomatosis and pulmonary hypertension.
Topics: Adolescent; Adult; Dyspnea; Female; Granuloma; Heroin Dependence; Humans; Hypertension, Pulmonary; I | 1976 |
Methylphenidate (ritalin) abuse and methadone maintenance.
Topics: Adult; Amphetamine; Atropa belladonna; Barbiturates; Diazepam; Female; Heroin Dependence; Humans; Ma | 1975 |
Childhood chemotherapy and later drug abuse and growth curve: a follow-up study of 30 adolescents.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Body Height; Cannabis; Child; Child Behav | 1975 |
Simultaneous detection of a wide variety of commonly abused drugs in a urine screening program using thin-layer identification techniques.
Topics: 1-Propanol; Ammonia; Ammonium Chloride; Amphetamine; Barbiturates; Chloroform; Chromatography, Thin | 1975 |
[Methylphenidate addiction--Reversal of effect on withdrawal].
Topics: Adult; Humans; Hunger; Male; Memory Disorders; Methylphenidate; Sleep Wake Disorders; Substance With | 1975 |
Methylphenidate: a review.
Topics: Attention Deficit Disorder with Hyperactivity; Humans; Hyperkinesis; Methylphenidate; Substance-Rela | 1976 |
Assessment of mazindol for abuse liability.
Topics: Dose-Response Relationship, Drug; Humans; Male; Mazindol; Methylphenidate; Psychomotor Performance; | 1990 |
Intranasal abuse of prescribed methylphenidate by an alcohol and drug abusing adolescent with ADHD.
Topics: Administration, Intranasal; Adolescent; Alcoholism; Arousal; Attention Deficit Disorder with Hyperac | 1991 |
Narcolepsy, paranoid psychosis, and analeptic abuse.
Topics: Adult; Dextroamphetamine; Dose-Response Relationship, Drug; Humans; Male; Methylphenidate; Middle Ag | 1989 |
Methylphenidate for cyclosporine-associated organic mood disorder.
Topics: Adult; Cyclosporins; Female; Humans; Methylphenidate; Substance-Related Disorders | 1989 |
Pulmonary talc granulomatosis due to intravenous ritalin.
Topics: Adenocarcinoma; Adult; Granuloma; Humans; Injections, Intravenous; Lung Neoplasms; Male; Methylpheni | 1988 |
Pathologic quiz case 1. Intense foreign body with abnormal polarizable material in the soft tissue.
Topics: Adult; Foreign-Body Reaction; Granuloma; Humans; Injections, Intravenous; Male; Methylphenidate; Nec | 1988 |
Family abuse of methylphenidate.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Family; Female; Humans; Male; Meth | 1988 |
Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse.
Topics: Adult; Dextropropoxyphene; Female; Granuloma; Humans; Liver; Lung; Methylphenidate; Myocardium; Pent | 1987 |
Severe precocious emphysema in intravenous methylphenidate (Ritalin) abusers.
Topics: Adult; Emphysema; Female; Humans; Injections, Intravenous; Lung Volume Measurements; Male; Methylphe | 1987 |
Psychosocial aspects of AIDS.
Topics: Acquired Immunodeficiency Syndrome; Attitude to Health; Brain Diseases; Child; Dementia; Dextroamphe | 1987 |
Gradual vs. abrupt withdrawal of methylphenidate in two older dependent males.
Topics: Aged; Humans; Male; Methylphenidate; Middle Aged; Substance-Related Disorders | 1985 |
Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine. A case report of treatment with intra-arterial urokinase and review.
Topics: Accidents; Adult; Forearm; Heroin; Humans; Injections, Intra-Arterial; Ischemia; Male; Methylphenida | 1985 |
Multiple organ failure resulting from intravenous abuse of methylphenidate hydrochloride.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dopamine; Female; Humans; Injections, Intravenous; Ki | 1985 |
Acute myelopathy in a drug abuser following an attempted neck vein injection.
Topics: Adult; Humans; Infusions, Parenteral; Male; Methylphenidate; Pentazocine; Spinal Cord Diseases; Subs | 1985 |
Methylphenidate treatment of cocaine abusers without attention deficit disorder: a negative report.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cocaine; Humans; Male; Methylphenidate; Substa | 1985 |
Pseudomonas aeruginosa cervical diskitis with chondro-osteomyelitis in an intravenous drug abuser.
Topics: Cervical Vertebrae; Humans; Injections, Intravenous; Intervertebral Disc; Male; Methylphenidate; Mid | 1973 |
[The chemical detection of doping among athletes].
Topics: Aminobutyrates; Amphetamine; Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Eph | 1966 |
[Catecholamine dependence. Pathogenesis and treatment].
Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Catecholamines; Humans; Metaraminol; Methylphe | 1970 |
The effects of chlorpromazine on psychomotor stimulant self-administration in the rhesus monkey.
Topics: Amphetamine; Animals; Behavior, Animal; Chlorpromazine; Cocaine; Drug Antagonism; Humans; Macaca; Me | 1972 |
Symposium: behavior modification by drugs. 3. The clinical use of stimulant drugs in children.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Feeding and Eat | 1972 |
Self-inflicted strokes.
Topics: Amphetamine; Animals; Cerebral Angiography; Cerebrovascular Disorders; Fundus Oculi; Haplorhini; Hum | 1972 |
Vascular complications of drug abuse.
Topics: Adult; Amphetamine; Amputation, Surgical; Aneurysm; Angiography; Arm; Arteries; Barbiturates; Blood | 1972 |
Amphetamine-type drugs for hyperactive children.
Topics: Appetite; Attention Deficit Disorder with Hyperactivity; Body Weight; Brain; Child; Dextroamphetamin | 1972 |
[Significance of amphetamine-like drugs in the psychodynamics of drug abuse in juveniles].
Topics: Adult; Amphetamine; Female; Hallucinations; Humans; Male; Methylphenidate; Psychoses, Substance-Indu | 1973 |
Hyperactive children.
Topics: Brain; Child; Dextroamphetamine; Humans; Hyperkinesis; Methylphenidate; Substance-Related Disorders | 1973 |
The continuing problem of barbiturate poisoning.
Topics: Accidents; Acidosis; Barbiturates; Diuresis; Drug Tolerance; Gastric Lavage; Humans; Mannitol; Methy | 1973 |
Methylphenidate.
Topics: Humans; Methylphenidate; Substance-Related Disorders | 1973 |
Patterns, range and effects of misused psychotropic substances in Europe.
Topics: Adolescent; Adult; Age Factors; Amphetamine; Analgesics; Cannabis; Drug and Narcotic Control; Europe | 1973 |
Fatal pulmonary hypertension from intravenous injection of methylphenidate (Ritalin) tablets.
Topics: Adult; Autopsy; Granuloma; Heart Failure; Humans; Hypertension, Pulmonary; Lung; Male; Methylphenida | 1972 |
Psychosis during methylphenidate abuse.
Topics: Adult; Female; Humans; Injections, Intravenous; Male; Methylphenidate; Paranoid Disorders; Psychoses | 1972 |
Talc and cornstarch emboli in eyes of drug abusers.
Topics: Adult; Edema; Embolism; Female; Foreign Bodies; Fundus Oculi; Granuloma; Humans; Hypertension, Pulmo | 1972 |
Folie à deux with methylphenidate psychosis.
Topics: Adult; Female; Humans; Interpersonal Relations; Male; Methylphenidate; Paranoid Disorders; Psychoses | 1972 |
[Alcohol and drugs in blood and urine. 100 consecutive cases of persons arrested by the Stockholm police].
Topics: Adolescent; Adult; Alcoholic Intoxication; Amines; Appetite Depressants; Barbiturates; Chromatograph | 1971 |
Methylphenidate problems.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Drug and Narcotic Control; Humans; Methylpheni | 1971 |
Drugs: use and abuse.
Topics: Adolescent; Child Psychiatry; Drug Therapy; Humans; Male; Methylphenidate; Substance-Related Disorde | 1971 |
Abuse of anorexics with special reference to newer substances.
Topics: Adolescent; Adult; Amines; Amphetamine; Appetite Depressants; Female; Humans; Methamphetamine; Methy | 1971 |
Methylphenidate and the hyperkinetic state.
Topics: Ataxia; Child; Drug Synergism; Feeding and Eating Disorders; Humans; Hyperkinesis; Hypertension; Met | 1971 |
Pulmonary talc granulomatosis. A complication of drug abuse.
Topics: Adult; Granuloma; Hemoptysis; Humans; Injections, Intravenous; Lung Diseases; Male; Methylphenidate; | 1970 |
Let the physician beware.
Topics: Depression; Fatigue; Humans; Methylphenidate; Substance-Related Disorders | 1970 |
Speed in Sweden.
Topics: Amphetamine; Humans; Methylphenidate; Phenmetrazine; Substance-Related Disorders; Sweden | 1970 |
Intravenous drug abuse. Pulmonary, cardiac, and vascular complications.
Topics: Adult; Aneurysm; Aneurysm, Infected; Endocarditis, Bacterial; Female; Heroin; Humans; Hypertension, | 1970 |
Drug interactions with anticoagulants.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Anticoagulants; Ascorbic Acid; Barbiturates; Blood Co | 1970 |
Abuse of methylphenidate (Ritalin).
Topics: Drug and Narcotic Control; Drug Prescriptions; Humans; Methylphenidate; Substance-Related Disorders; | 1971 |
[Folie à deux associated with methylphenidate addiction].
Topics: Adult; Family Characteristics; Female; Humans; Male; Methylphenidate; Personality Assessment; Psycho | 1971 |
Metastatic endophthalmitis associated with injection of addictive drugs.
Topics: Adult; Amphetamine; Aspergillosis; Cannabis; Eye Diseases; Heroin; Humans; Inflammation; Injections, | 1971 |
[Cerebral stimulants of the amine group in child behavior disorders?].
Topics: Child; Child Behavior Disorders; Humans; Methylphenidate; Phenmetrazine; Substance-Related Disorders | 1971 |
Learning disorders, hyperkinesis, and the use of drugs in children.
Topics: Amphetamine; Child; Humans; Hyperkinesis; Learning Disabilities; Methylphenidate; Psychological Test | 1971 |
[Inoculation hepatitis in narcomaniacs and after tattooing].
Topics: Adult; Cannabis; Hepatitis B; Humans; Injections, Intravenous; Male; Methylphenidate; Opium; Phenmet | 1967 |
Drugs for depression.
Topics: Amphetamine; Antidepressive Agents; Humans; Methylphenidate; Monoamine Oxidase Inhibitors; Obesity; | 1968 |
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine | 1968 |
Methylphenidate (Ritalin).
Topics: Anorexia Nervosa; Antidepressive Agents; Anxiety; Depression; Humans; Methylphenidate; Sleep Initiat | 1969 |