Page last updated: 2024-10-31

methylphenidate and Chemical Dependence

methylphenidate has been researched along with Chemical Dependence in 360 studies

Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.

Research Excerpts

ExcerptRelevanceReference
"Case reports of five patients suffering from either skin abscesses or cellulitis following parenteral methylphenidate abuse are presented."7.65Abscess formation as a complication of parenteral methylphenidate abuse. ( Elenbaas, RM; McNabney, WK; Waeckerie, JF, 1976)
"Intravenous (IV) drug abuse is known to cause pulmonary tale granulomatosis."5.27Severe precocious emphysema in intravenous methylphenidate (Ritalin) abusers. ( Hudson, LD; Pierson, DJ; Sherman, CB, 1987)
"Medication with methylphenidate should be avoided in patients with vulnerability to schizophrenia and in drug addiction, but reported cases without these risk factors demonstrate that a careful and regular psychiatric monitoring is essential in all patients treated with methylphenidate."4.86Methylphenidate-induced psychosis in adult attention-deficit/hyperactivity disorder: report of 3 new cases and review of the literature. ( Kis, B; Kraemer, M; Uekermann, J; Wiltfang, J, 2010)
"Literature review using a National Library of Medicine database search for 1975 through March 1997 on the terms attention deficit disorder with hyperactivity, methylphenidate, stimulants, and stimulant abuse and dependence."4.80Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association. ( Bezman, RJ; Genel, M; Goldman, LS; Slanetz, PJ, 1998)
"We describe a case of pulmonary granulomatosis in a user who habitually injected methylphenidate (Ritalin) intravenously; symptomatic and objective improvement occurred with corticosteroid therapy."3.6667Gallium scanning in talc-induced pulmonary granulomatosis. ( Aguirre, A; Brown, DG; Weaver, A, 1980)
"A 28-year-old woman with a long history of drug abuse experienced flaccid quadriplegia and bilateral loss of posterior column sensation a few minutes after an intravenous (IV) injection of methylphenidate hydrochloride."3.66Medial medullary syndrome in a drug abuser. ( Gonatas, NK; Lewis, RA; Mizutani, T, 1980)
"Case reports of five patients suffering from either skin abscesses or cellulitis following parenteral methylphenidate abuse are presented."3.65Abscess formation as a complication of parenteral methylphenidate abuse. ( Elenbaas, RM; McNabney, WK; Waeckerie, JF, 1976)
"There was no difference in days of substance use or ADHD symptom outcomes over time in adolescents with MDD or those without MDD treated with OROS-MPH or placebo."2.77Major depression and treatment response in adolescents with ADHD and substance use disorder. ( Mikulich-Gilbertson, SK; Min, SJ; Riggs, PD; Tamm, L; Trello-Rishel, K; Warden, D; Winhusen, T, 2012)
" However, repeat dosing has not been examined."2.77Importance of pharmacokinetic profile and timing of coadministration of short- and long-acting formulations of methylphenidate on patterns of subjective responses and abuse potential. ( Batchelder, H; Biederman, J; Clarke, A; Faraone, SV; Martin, JM; Mirto, T; Moorehead, TM; Spencer, TJ, 2012)
"Psychostimulants are effective treatments for attention-deficit/hyperactivity disorder (ADHD) but may be associated with euphoric effects, misuse/diversion, and adverse effects."2.76Subjective effects, misuse, and adverse effects of osmotic-release methylphenidate treatment in adolescent substance abusers with attention-deficit/hyperactivity disorder. ( Adler, LA; Davies, RD; Lewis, DF; Riggs, PD; Somoza, EC; Sonne, S; Winhusen, TM, 2011)
"Differences in substance use were revealed in favor of the UCPP, with more adolescents in the CU group smoking cigarettes in the last month (UCPP 17%, CU 42%; chi2 = 4."2.73Preventive effects of treatment of disruptive behavior disorder in middle childhood on substance use and delinquent behavior. ( Lochman, JE; Matthys, W; van de Wiel, NMH; Zonnevylle-Bender, MJS, 2007)
"Methylphenidate has potential for abuse because it produces behavioural effects similar to those observed with other abused stimulants, such as d-amphetamine and cocaine."2.71Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans. ( Fillmore, MT; Glaser, PE; Rush, CR; Stoops, WW, 2004)
"Modafinil is a unique wake-promoting agent."2.69An evaluation of the abuse potential of modafinil using methylphenidate as a reference. ( Jasinski, DR, 2000)
" Deviations from suggested routes of administration such as crushing, chewing, intravenous administration, or snorting stimulant medication may alter the release rate, absorption, and bioavailability of the active drug."2.53Safety and efficacy considerations due to misuse of extended-release formulations of stimulant medications. ( Jain, R; Stark, JG, 2016)
"Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD)."2.53From Clinical Application to Cognitive Enhancement: The Example of Methylphenidate. ( Busardò, FP; Cipolloni, L; Frati, P; Kyriakou, C; Zaami, S, 2016)
"ADHD is often comorbid with substance use disorder (SUD), with Odds Ratio ranges from 1."2.52Methylphenidate in Adults with Attention Deficit Hyperactivity Disorder and Substance Use Disorders. ( Karila, L; Rolland, B; Simon, N, 2015)
" While medications for ADHD are generally well-tolerated, there are common, although less severe, as well as rare but severe adverse events AEs during treatment with ADHD drugs."2.49Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents. ( Banaschewski, T; Buitelaar, J; Coghill, D; Cortese, S; Danckaerts, M; Dittmann, RW; Graham, J; Holtmann, M; Sergeant, J; Taylor, E, 2013)
"Comorbid psychiatric disorders should be addressed with disorder-specific therapies while associated symptoms also often improve with treatment of the ADHD core symptoms."2.49[Adult attention deficit/hyperactivity disorder, associated symptoms and comorbid psychiatric disorders: diagnosis and pharmacological treatment]. ( Alm, B; Paslakis, G; Schredl, M; Sobanski, E, 2013)
"Clinical (presence of co-morbid substance use disorders [SUD]) and methodological (design and rater) covariates were also collected, in addition to clinical trial reporting quality."2.47Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis. ( Bosch, R; Casas, M; Castells, X; Nogueira, M; Ramos-Quiroga, JA; Rigau, D; Vidal, X, 2011)
" They are generally safe in special populations."2.45Safety of stimulant treatment in attention deficit hyperactivity disorder: Part I. ( Kuchibhatla, A; Merkel, RL, 2009)
"d-Amphetamine has a mechanism independent of neuronal firing rate, displacing intraneuronal stores of catecholamines, delaying their reuptake and inhibiting catabolism by monoamine oxidase."2.45The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety. ( Cheetham, SC; Heal, DJ; Smith, SL, 2009)
" There is little information on the long-term safety of methylphenidate in adults, although the number of serious adverse effects reported to regulatory authorities has, so far, been low."2.45Safety of therapeutic methylphenidate in adults: a systematic review of the evidence. ( Godfrey, J, 2009)
"Psychotherapy is still the mainstay of treatment; however, relapse rates are high."2.44Pharmacotherapy of methamphetamine addiction: an update. ( Elkashef, A; Hanson, G; Tiihonen, J; Vocci, F; White, J; Wickes, W, 2008)
"Adolescents tend to have shorter substance use histories therefore they often experience emergency/acute care health treatment resulting from substance use related trauma and/or overdose."2.43Adolescent substance use: brief interventions by emergency care providers. ( Burke, PJ; O'Sullivan, J; Vaughan, BL, 2005)
"Methylphenidate, the most common treatment for attention deficit hyperactivity disorder (ADHD), increases extracellular dopamine in the brain, which is associated with its reinforcing as well as its therapeutic effects."2.42Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. ( Swanson, JM; Volkow, ND, 2003)
"When used to treat children with Attention Deficit Hyperactivity Disorder, methylphenidate (MPH) acts primarily by blocking the dopamine (DA) transporter (DAT) and increasing extracellular DA in the striatum."2.42Serum and brain concentrations of methylphenidate: implications for use and abuse. ( Swanson, JM; Volkow, ND, 2003)
"Obesity is a major public health problem."2.41The role of dopamine in motivation for food in humans: implications for obesity. ( Fowler, JS; Volkow, ND; Wang, GJ, 2002)
"However, current substance abuse precludes use of the drug and former abuse liability and social adjustment problems are relative contraindications."2.40[Central nervous system stimulants and their potential risk of abuse in hyperkinetic disorders]. ( Aanonsen, NO, 1999)
"Evaluations for ADHD and substance abuse were completed."2.39The dual diagnosis of attention-deficit/hyperactivity disorder and substance abuse: case reports and literature review. ( Isaacson, JH; Musial, J; Schubiner, H; Tzelepis, A; Warbasse, LH; Zacharek, M, 1995)
" We postulate that periodic and frequent stimulation of the dopaminergic system secondary to chronic use of cocaine favors activation of a circuit that involves the orbitofrontal cortex, cingulate gyrus, thalamus and striatum."2.39Cocaine addiction: hypothesis derived from imaging studies with PET. ( Ding, YS; Fowler, JS; Volkow, ND; Wang, GJ, 1996)
"A minority of alcohol abusers develop severe cerebral dysfunction in the form of Wernicke-Korsakoff syndrome."2.35Chronic cerebral effects of alcohol and drug abuse. ( Grant, I; Mohns, L, 1975)
"The Monitor Mental Health and Substance Use (2021) shows that almost one in twenty students has used ADHD medication for non-medical use at least once in the past year."1.91[ADHD medication to improve academic performance?] ( Bakker, M; van den Berk-Bulsink, MJE; van der Horst, M, 2023)
"Methylphenidate is an effective first-line treatment for attention-deficit/hyperactivity disorder (ADHD)."1.91The Adverse Effects and Nonmedical Use of Methylphenidate Before and After the Outbreak of COVID-19: Machine Learning Analysis. ( Kim, E; Lee, H; Oh, S; Park, S; Purja, S; Shin, H; Yuniar, CT, 2023)
"The drug use history and drug abuse motivation scale were collected at admission."1.72Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder. ( Mao, F; Sun, P; Wang, N; Xu, J; Yuan, TF; Zhang, Y, 2022)
"Methylphenidate was the drug used by the highest percentage of the population (2."1.72[Trend in medicines use for attention deficit hyperactivity disorder in children and adolescents (2010-2019).] ( Alberola López, S; Andrés de Llano, JM; Gutiérrez-Abejón, E; Prieto Antolín, B, 2022)
"Methylphenidate (MPH) is a mild CNS stimulant that has been used in hyperactive children, and patients with neurodegenerative and major depressive disorders."1.62Cannabidiol attenuated the maintenance and reinstatement of extinguished methylphenidate-induced conditioned place preference in rats. ( Haghparast, A; Jamali, S; Kashefi, A; Rashidy-Pour, A; Tomaz, C; Vafaei, AA, 2021)
"We evaluated the risk of drug abuse and dependence (DAAD) related to substances that are known to be used for PNE and divided this group into agents with (methylphenidate) and without a known abuse potential outside the field of PNE (atomoxetine, modafinil, acetylcholine esterase inhibitors, and memantine)."1.46Sensitivity of Quantitative Signal Detection in Regards to Pharmacological Neuroenhancement. ( Connemann, BJ; Gahr, M; Schönfeldt-Lecuona, C; Zeiss, R, 2017)
" We here propose analytical methods to disclose acute and chronic use of two types of new psychostimulants: benzofurans and ethylphenidate and we applied them to a real case of a subject attending Emergency Department with signs of acute intoxication due to psychotropic drug(s)."1.46Intoxication caused by new psychostimulants: analytical methods to disclose acute and chronic use of benzofurans and ethylphenidate. ( Barceló, B; Busardò, FP; Elorza, MÁ; Gomila, I; Kyriakou, C; Marchei, E; Pichini, S; Roset, C; Rotolo, MC, 2017)
" Lack of longitudinal follow-up studies of dosing and adverse effects has resulted in conflicting treatment guidelines."1.46Methylphenidate doses in Attention Deficit/Hyperactivity Disorder and comorbid substance use disorders. ( Brandt, L; D'Onofrio, B; Franck, J; Larsson, H; Skoglund, C, 2017)
"The most common comorbidities were substance use disorders (39."1.43Psychiatric Comorbidity at the Time of Diagnosis in Adults With ADHD: The CAT Study. ( Balanzá-Martínez, V; García-García, P; Piñeiro-Dieguez, B; Soler-López, B, 2016)
"Ethylphenidate was specifically mentioned in the cause of death for 5 cases, chronic intravenous (IV) drug use was named as part of the cause of death for 2 cases and in 6 cases there was evidence of complications and infections through IV drug use."1.42A review of ethylphenidate in deaths in east and west Scotland. ( McKeown, D; Parks, C; Torrance, HJ, 2015)
"The association of substance use disorders (SUD) with attention-deficit disorder (ADHD), co-morbid mental disorders, and medication has only been studied in isolation and in rather small samples."1.40Substance use disorders in association with attention-deficit/hyperactivity disorder, co-morbid mental disorders, and medication in a nationwide sample. ( Bisgaard, C; Steinhausen, HC, 2014)
"Diagnoses of SUD and alcohol abuse were obtained from The Danish Psychiatric Central Register."1.40ADHD, stimulant treatment in childhood and subsequent substance abuse in adulthood - a naturalistic long-term follow-up study. ( Dalsgaard, S; Frydenberg, M; Mortensen, PB; Thomsen, PH, 2014)
"Pretreatment with methylphenidate (0."1.37Comparison of the effects of methamphetamine, bupropion, and methylphenidate on the self-administration of methamphetamine by rhesus monkeys. ( Gilman, JP; Goldberg, SR; McCann, DJ; Panlilio, LV; Schindler, CW, 2011)
"A history of multiple substance use may be a risk factor for non-medical use of methylphenidate."1.37Severe toxicity due to injected but not oral or nasal abuse of methylphenidate tablets. ( Bodmer, M; Bruggisser, M; Liechti, ME, 2011)
"Methylphenidate is a psychostimulant drug indicated for the treatment of attention-deficit hyperactivity disorder (ADHD)."1.37Patterns of methylphenidate use and assessment of its abuse and diversion in two French administrative areas using a proxy of deviant behaviour determined from a reimbursement database: main trends from 2005 to 2008. ( Coudert, H; Frauger, E; Micallef, J; Natali, F; Pauly, V; Pradel, V; Reggio, P; Thirion, X, 2011)
"However, it has been demonstrated that drug addiction is associated with dopaminergic system changes that may affect MPH brain effects, emphasizing the need to better understand MPH actions in subjects with ADHD+SUD."1.35Methylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study. ( Bressan, RA; Fu, YK; Hoexter, MQ; Júnior, N; Pechansky, F; Rohde, LA; Schaefer, T; Shih, MC; Szobot, CM, 2008)
"Even when controlling for substance use disorder, age at stimulant treatment initiation was significantly and positively related to the later development of antisocial personality disorder."1.35Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. ( Castellanos, FX; Howell, KH; Klein, RG; Mannuzza, S; Moulton, JL; Roizen, ER; Truong, NL, 2008)
"Drug ID and drug abuse calls were assessed by call year and geographic location."1.33Methylphenidate abuse in Texas, 1998-2004. ( Forrester, MB, 2006)
"This new drug abuse prevention paradigm holds great promise for efforts to reduce the nonmedical use of prescription controlled substances, including the prescription stimulants used to treat ADHD."1.33Abuse-resistant drug delivery. ( Bensinger, PB; DuPont, RL, 2006)
"Methylphenidate (MPH) is a prescription stimulant drug with known abuse potential; however, little is known about its patterns of misuse or the characteristics of its abusers."1.33Characteristics of methylphenidate misuse in a university student sample. ( Barrett, SP; Bordy, LE; Darredeau, C; Pihl, RO, 2005)
"Methylphenidate is a central nervous system stimulant used for the treatment of attention deficit hyperactivity disorder and narcolepsy and like other psychostimulants has a potential for abuse."1.32Lacunar stroke associated with methylphenidate abuse. ( Sadeghian, H, 2004)
"Pretreatment with methylphenidate decreased binding only in striatum (40%)."1.29Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. ( Ashby, C; Dewey, S; Ding, YS; Fowler, JS; Gatley, JS; Hitzemann, R; Liebermann, J; Logan, J; Volkow, ND; Wang, GJ, 1995)
" Antidepressant medications, both TCAs and MAOIs, often help relieve the symptoms of depression that emerge when chronic use of cocaine is discontinued."1.27Cocaine abuse and its treatment. ( Resnick, EB; Resnick, RB, 1984)
"The granulomas are associated with a history of intravenous injection of medications (Ritalin and Talwin) intended for oral use."1.27Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse. ( Edland, JF; Lundquest, DE; Young, WK, 1987)
"Intravenous (IV) drug abuse is known to cause pulmonary tale granulomatosis."1.27Severe precocious emphysema in intravenous methylphenidate (Ritalin) abusers. ( Hudson, LD; Pierson, DJ; Sherman, CB, 1987)
"Bereavement after diagnosing AIDS or other HIV disease, psychological symptoms secondary to brain disease and the social consequences of having AIDS all interact to produce a devastating illness where the patient may be intensely grieving, demented and totally rejected by all of society."1.27Psychosocial aspects of AIDS. ( Goldmeier, D, 1987)
" Dose-response differences were also revealed in "breaking point" comparisons between secobarbital on the one hand, and methylphenidate and cocaine, on the other."1.26Behavioral procedures for evaluating the relative abuse potential of CNS drugs in primates. ( Brady, JV; Griffiths, RR, 1976)
" Dosage should be titrated individually for each patient, and it is best to start with small doses given at least 15 to 30 minutes before meals."1.26Methylphenidate: a review. ( Majovski, LV; Oettinger, L, 1976)
"Thirty adolescents with histories of minimal brain dysfunction who had been treated for at least six months with chemotherapy were compared with 30 adolescents who had not been so treated."1.25Childhood chemotherapy and later drug abuse and growth curve: a follow-up study of 30 adolescents. ( Beck, L; Langford, WS; Mackay, M; Sum, G, 1975)

Research

Studies (360)

TimeframeStudies, this research(%)All Research%
pre-1990112 (31.11)18.7374
1990's23 (6.39)18.2507
2000's99 (27.50)29.6817
2010's110 (30.56)24.3611
2020's16 (4.44)2.80

Authors

AuthorsStudies
Arvidsson, M2
Franck, J5
Ackehed, G1
Pettersson Bergstrand, M1
Ekström, L1
Rosenborg, S1
Dahl, ML2
Prieto Antolín, B1
Gutiérrez-Abejón, E1
Alberola López, S1
Andrés de Llano, JM1
Elgueta-Reyes, M1
Velásquez, VB1
Espinosa, P1
Riquelme, R1
Dib, T1
Sanguinetti, NK1
Escobar, AP1
Martínez-Pinto, J1
Renard, GM1
Sotomayor-Zárate, R1
Xu, J1
Zhang, Y1
Wang, N1
Sun, P1
Mao, F1
Yuan, TF1
van den Berk-Bulsink, MJE1
Bakker, M1
van der Horst, M1
Tschudi, L1
Fischer, SKM1
Perlov, E1
Baumgartner, MR1
Soyka, M1
Müller, TJ1
Seifritz, E1
Mutschler, J1
Shin, H1
Yuniar, CT1
Oh, S1
Purja, S1
Park, S1
Lee, H1
Kim, E1
Shoff, EN1
Kahl, JH1
Hime, GW1
Coburn, M1
Boland, DM1
de Oliveira Cata Preta, B1
Miranda, VIA1
Bertoldi, AD1
Tardelli, VS1
Bisaga, A1
Arcadepani, FB1
Gerra, G1
Levin, FR3
Fidalgo, TM1
Shellenberg, TP1
Stoops, WW2
Lile, JA1
Rush, CR4
Ponnet, K1
Tholen, R1
De Bruyn, S1
Wouters, E1
Van Ouytsel, J1
Walrave, M1
Van Hal, G1
Kashefi, A1
Tomaz, C1
Jamali, S1
Rashidy-Pour, A1
Vafaei, AA1
Haghparast, A1
Miranda, M1
Barbosa, M1
Cunill, R1
Castells, X2
González-Pinto, A1
Arrojo, M1
Bernardo, M1
Sáiz, PA1
Flórez, G1
Torrens, M1
Tirado-Muñoz, J1
Fonseca, F1
Arranz, B1
Garriga, M1
Goikolea, JM1
Zorrilla, I1
Becoña, E1
López, A1
San, L1
Zhang, R1
Manza, P1
Tomasi, D1
Kim, SW1
Shokri-Kojori, E1
Demiral, SB1
Kroll, DS1
Feldman, DE1
McPherson, KL1
Biesecker, CL1
Wang, GJ12
Volkow, ND16
Moore, TJ1
Wirtz, PW1
Kruszewski, SP1
Alexander, GC1
Schrantee, A1
Bouziane, C1
Bron, EE1
Klein, S1
Bottelier, MA1
Kooij, JJS1
Rombouts, SARB1
Reneman, L1
Barceló, B1
Gomila, I1
Rotolo, MC1
Marchei, E1
Kyriakou, C2
Pichini, S1
Roset, C1
Elorza, MÁ1
Busardò, FP2
Skoglund, C2
Brandt, L2
D'Onofrio, B1
Larsson, H2
Abelman, DD1
Iglseder, B1
Crunelle, CL2
van den Brink, W1
Moggi, F1
Konstenius, M2
van de Glind, G1
Demetrovics, Z1
Coetzee, C1
Luderer, M1
Schellekens, A1
Matthys, F1
Jang, M1
Kim, J1
Shin, I1
Kang, S1
Choi, H1
Yang, W1
Wiig, EH1
Nielsen, NP1
Korn, L1
Hassan, K1
Fainshtein, N1
Yusov, N1
Davidovitch, N1
Adorjan, K1
Karch, S1
Martin, G1
Plörer, D1
Winter, C1
Hantschk, I1
Koller, G1
Erbas, B1
Pogarell, O1
Scholz, I1
Schmid, Y1
Exadaktylos, AK1
Haschke, M1
Liechti, ME3
Liakoni, E1
Yadav-Samudrala, BJ1
Eltit, JM1
Glennon, RA1
Dela Peña, I1
Kim, BN1
Han, DH1
Kim, Y1
Cheong, JH1
Looby, A3
De Young, KP1
Earleywine, M3
Dubljević, V2
Sandberg, A2
Hall, W2
Partridge, B1
Lucke, J1
Levy, N1
Greely, HT1
Forlini, C1
Racine, E1
Vollmann, J1
Schildmann, J1
LaBuzetta, JN1
Brewer, CD1
DeGrote, H1
Faulmüller, N1
Maslen, H1
de Sio, FS1
Flanigan, J1
van der Eijk, Y1
Savulescu, J1
Paslakis, G1
Schredl, M1
Alm, B1
Sobanski, E1
Cassidy, TA2
McNaughton, EC1
Varughese, S3
Russo, L2
Zulueta, M1
Butler, SF2
Dalsgaard, S1
Mortensen, PB1
Frydenberg, M1
Thomsen, PH1
Spada, MM1
van Emmerik-van Oortmerssen, K1
Carpentier, PJ2
Steinhausen, HC1
Bisgaard, C1
Lapeyre-Mestre, M1
Gony, M1
Carvajal, A1
Macias, D1
Conforti, A1
D'Incau, P1
Heerdink, R1
Van der Stichele, R1
Bergman, U1
Piñeiro-Dieguez, B1
Balanzá-Martínez, V1
García-García, P1
Soler-López, B1
Hildt, E3
Lieb, K3
Franke, AG3
Calipari, ES1
Jones, SR1
Uchiyama, N1
Matsuda, S1
Kawamura, M1
Shimokawa, Y1
Kikura-Hanajiri, R1
Aritake, K1
Urade, Y1
Goda, Y1
Jensen, LS2
Pagsberg, AK2
Dalhoff, K1
Hay, E1
Shklovski, V1
Blaer, Y1
Shlakhover, V1
Katz, A1
Clemow, DB1
Walker, DJ1
Jonsson, B1
Backman, E1
Salmonson, H1
Höjer, J1
Lampert, A1
Tesarz, J1
Volkert, AK1
Wesche, D1
Wild, B1
Schwab, M1
Haefeli, WE1
Eslami, AA1
Jalilian, F1
Ataee, M1
Alavijeh, MM1
Mahboubi, M1
Afsar, A1
Aghaei, A1
Giacobini, M1
Medin, E1
Ahnemark, E1
Russo, LJ1
Carlqvist, P1
Vrecko, S1
Peles, E1
Schreiber, S1
Linzy, S1
Domani, Y1
Adelson, M1
Dalhoff, KP1
Bailey, GP1
Ho, JH1
Hudson, S1
Dines, A1
Archer, JR1
Dargan, PI1
Wood, DM1
Chen, LY1
Crum, RM1
Strain, EC1
Martins, SS1
Mojtabai, R1
Pignon, B1
Muyssen, A1
Deheul, S1
Cottencin, O1
Rolland, B2
Bagusat, C1
Simon, N1
Karila, L1
Ram, SS1
Hussainy, S1
Henning, M1
Jensen, M1
Russell, B1
Parks, C2
McKeown, D1
Torrance, HJ1
Mamey, MR1
Barbosa-Leiker, C1
McPherson, S1
Burns, GL1
Roll, J1
Tagaya, H2
Murayama, N1
Fukase, Y1
Barkla, XM1
McArdle, PA1
Newbury-Birch, D1
Koblan, KS1
Hopkins, SC1
Sarma, K1
Gallina, N1
Jin, F1
Levy-Cooperman, N1
Schoedel, KA3
Loebel, A1
Cipolloni, L1
Zaami, S1
Frati, P1
Bisagno, V1
González, B1
Urbano, FJ1
Dance, A1
Dunlop, AJ1
Newman, LK1
Cairns, R1
Daniels, B1
Wood, DA1
Brett, J1
Almqvist, C1
DʼOnofrio, BM1
Motaghinejad, M1
Motevalian, M1
Eggleston, W1
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Clinical Trials (13)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Brain Dopaminergic Signaling in Opioid Use Disorders (OUD)[NCT03190954]Early Phase 1300 participants (Anticipated)Interventional2017-08-17Recruiting
Assessing Cognitive Performance Among Adults With Attention Disorders Working on Treadmill[NCT05243186]Phase 2/Phase 330 participants (Anticipated)Interventional2021-10-01Recruiting
The Effects of Methylphenidate (MPH) and Non-invasive Brain Stimulation (tDCS) on Inhibitory Control Children With Attention-Deficit/Hyperactivity Disorder (ADHD)[NCT04964427]26 participants (Actual)Interventional2021-02-08Completed
Investigating the Efficacy of Cognitive Behavioral Therapy in Patients With Substance Use Disorder and Comorbid ADHD. A Randomized Controlled Trial With Cognitive Behavioral Therapy[NCT01431235]184 participants (Actual)Interventional2011-08-31Completed
Randomized Controlled Trial of Osmotic-Release Methylphenidate (OROS-MPH) for Attention Deficit Hyperactivity Disorder (ADHD) in Adolescents With Substance Use Disorders (SUD)[NCT00264797]Phase 3303 participants (Actual)Interventional2006-02-28Completed
A Single Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate Efficacy of PR OROS Methylphenidate Followed by Open-Label Extension, in Swedish Male Prison Inmates With ADHD[NCT00482313]Phase 330 participants (Actual)Interventional2007-05-31Completed
Methylphenidate Transdermal System (MTS) in the Treatment of Adult ADHD[NCT00506285]Phase 392 participants (Actual)Interventional2007-06-30Completed
Implications of Tamarkoz® on Reducing Stress and Heart Rate, and Increasing Positive Emotions, Spirituality[NCT03489148]103 participants (Actual)Interventional2015-08-24Completed
A Double-blind, Randomized, Placebo-controlled, Crossover Study of Repeat Dosing of OROS® Methylphenidate Hydrochloride (CONCERTA®) and Immediate Release Methylphenidate Hydrochloride in Healthy Adults[NCT00302458]Phase 444 participants (Actual)Interventional2006-01-31Completed
Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (rTMS) in Pediatric Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Cohorts (ADHD): a Randomized, Sham-controlled Study.[NCT06069323]80 participants (Anticipated)Interventional2023-06-01Recruiting
Efficacy of Cognitive Behavioral Therapy in Treatment of Adults With Attention Deficit Hyperactivity Disorder[NCT02210728]200 participants (Anticipated)Interventional2006-04-30Active, not recruiting
Brain Activation in Response to Motivational and Affective Stimuli: Pharmacological Manipulations[NCT00047866]38 participants (Actual)Observational2002-10-12Completed
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]Phase 4105 participants (Actual)Interventional2016-02-29Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

ADHD Severity

DSM IV ADHD Rating Scale (ADHD-RS) adolescent informant, ascertained at baseline and weekly throughout the 16 week study. This scale is an 18-item symptom checklist of self-reported adolescent ADHD symptoms. Symptoms are scored as None (0), Mild (1), Moderate (2), and Severe (3), with a summary total of scores for the 18 symptoms. Possible scores range from 0 to 54, with higher scores indicating greater severity. Outcome is measured as the decrease in total severity score over time. (NCT00264797)
Timeframe: baseline and 20 weeks

Interventionunits on a scale (Mean)
Methylphenidate-20.6
Methylphenidate (Placebo)-21.8

OROS-MPH Abuse Liability

Assessed by pill counts in conjunction with weekly review of subjects' medication diaries and self-reported medication compliance. (NCT00264797)
Timeframe: 20 weeks

Interventionpills (Mean)
Methylphenidate15.4
Methylphenidate (Placebo)9.7

Substance Use

The change in number of days of substance use from baseline to end of the trial. The number of days of non-tobacco drug/alcohol ascertained using standard timeline follow back (TLFB) procedures. (NCT00264797)
Timeframe: 20 weeks

Interventiondays (Mean)
Methylphenidate-5.7
Methylphenidate (Placebo)-5.2

Substance Use Outcomes

The mean number of negative urine drug screens (UDS). (NCT00264797)
Timeframe: 20 weeks

Interventionnegative UDS (Mean)
Methylphenidate3.8
Methylphenidate (Placebo)2.8

Conners' Adult ADHD Rating Scales (CAARS)

Measures the DSM based ADHD criteria of Inattention and Hyperactivity/Impulsivity. There are 30 items scored 0-3 for a minimum score of 0 (no symptoms) and a maximum score of 90 worst possible symptoms. (NCT00506285)
Timeframe: Double-blind endpoints for MTS and placebo arms

Interventionunits on a scale (Mean)
Scores in MTS Arm30.8
Scores in Placebo Arm49.5

Wender Reimherr Adult Attention Deficit Disorder Scale

This scale measures the 7 domains of the Utah Criteria for Adult ADHD. Total scores run from 0 to 28. Normative samples average below 5. The worst possible score is 28. (NCT00506285)
Timeframe: Double-blind endpoints during MTS and placebo arms

Interventionunits on a scale (Mean)
Scores in MTS Arm11.0
Scores in Placebo Arm17.9

Peak Plasma Concentration of d-Methylphenidate

Objective measure determined from blood samples, measured 4 hours after the dose (NCT00302458)
Timeframe: 4 hours

Interventionmg/L (Mean)
Placebo- Placebo0.00
IR-MPH + OROS MPH15.06
IR-MPH +IR-MPH25.34
OROS-MPH+OROS-MPH20.34
OROS-MPH+ IR-MPH28.79

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Interventionminutes (Mean)
Placebo53.5
Modafinil61.0

Postanesthesia Quality Recovery Scale Score

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Interventionunits on a scale (Mean)
Placebo-5.67
Modafinil-8.91

Reviews

76 reviews available for methylphenidate and Chemical Dependence

ArticleYear
Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.
    Psychopharmacology, 2020, Volume: 237, Issue:8

    Topics: Amphetamine; Central Nervous System Stimulants; Cocaine; Double-Blind Method; Humans; Lisdexamfetami

2020
An update on the clinical pharmacology of methylphenidate: therapeutic efficacy, abuse potential and future considerations.
    Expert review of clinical pharmacology, 2020, Volume: 13, Issue:8

    Topics: Abuse-Deterrent Formulations; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous

2020
Clinical practice guideline on pharmacological and psychological management of adult patients with attention deficit and hyperactivity disorder and comorbid substance use.
    Adicciones, 2022, Apr-01, Volume: 34, Issue:2

    Topics: Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys

2022
Mitigating risks of students use of study drugs through understanding motivations for use and applying harm reduction theory: a literature review.
    Harm reduction journal, 2017, 10-06, Volume: 14, Issue:1

    Topics: Academic Success; Adolescent; Adult; Amphetamines; Central Nervous System Stimulants; Dexmethylpheni

2017
[Doping for the brain].
    Zeitschrift fur Gerontologie und Geriatrie, 2018, Volume: 51, Issue:2

    Topics: Aged; Amphetamines; Brain; Cognitive Aging; Dietary Supplements; Humans; Illicit Drugs; Methylphenid

2018
[Adult attention deficit hyperactivity disorder (ADHD) with comorbid addictive disorder. Therapeutic challenges using the example of a survey of clinical practice].
    MMW Fortschritte der Medizin, 2019, Volume: 161, Issue:Suppl 5

    Topics: Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys

2019
Abuse and dependence liability analysis of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder (ADHD): what have we learned?
    Archives of pharmacal research, 2013, Volume: 36, Issue:4

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Addictive; Behavior, Animal; Blood

2013
[Adult attention deficit/hyperactivity disorder, associated symptoms and comorbid psychiatric disorders: diagnosis and pharmacological treatment].
    Fortschritte der Neurologie-Psychiatrie, 2013, Volume: 81, Issue:8

    Topics: Adult; Anxiety; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Co

2013
An overview of problematic internet use.
    Addictive behaviors, 2014, Volume: 39, Issue:1

    Topics: Antidepressive Agents, Second-Generation; Behavior, Addictive; Central Nervous System Stimulants; Ci

2014
[Substance use disorders and ADHD: an overview of recent Dutch research].
    Tijdschrift voor psychiatrie, 2013, Volume: 55, Issue:11

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity; Human

2013
The potential for misuse and abuse of medications in ADHD: a review.
    Postgraduate medicine, 2014, Volume: 126, Issue:5

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Amphetamine-Related Disorders; A

2014
Methylphenidate in Adults with Attention Deficit Hyperactivity Disorder and Substance Use Disorders.
    Current pharmaceutical design, 2015, Volume: 21, Issue:23

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity

2015
[Methylphenidate].
    Nihon rinsho. Japanese journal of clinical medicine, 2015, Volume: 73, Issue:9

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; J

2015
Are there any potentially dangerous pharmacological effects of combining ADHD medication with alcohol and drugs of abuse? A systematic review of the literature.
    BMC psychiatry, 2015, Oct-30, Volume: 15

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Alcohol Drinking; Atomoxetine Hydrochloride; Attention Def

2015
From Clinical Application to Cognitive Enhancement: The Example of Methylphenidate.
    Current neuropharmacology, 2016, Volume: 14, Issue:1

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognition

2016
Cognitive enhancers versus addictive psychostimulants: The good and bad side of dopamine on prefrontal cortical circuits.
    Pharmacological research, 2016, Volume: 109

    Topics: Animals; Benzhydryl Compounds; Central Nervous System Stimulants; Cocaine; Dopamine; Humans; Methamp

2016
Generation Z: Adolescent Xenobiotic Abuse in the 21st Century.
    Adolescent medicine: state of the art reviews, 2015, Volume: 26, Issue:3

    Topics: Adolescent; Amphetamine-Related Disorders; Cannabinoids; Central Nervous System Stimulants; Designer

2015
Safety and efficacy considerations due to misuse of extended-release formulations of stimulant medications.
    Postgraduate medicine, 2016, Volume: 128, Issue:7

    Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Dosag

2016
Safety of therapeutic methylphenidate in adults: a systematic review of the evidence.
    Journal of psychopharmacology (Oxford, England), 2009, Volume: 23, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Evidence-Ba

2009
Pharmacotherapy of methamphetamine addiction: an update.
    Substance abuse, 2008, Volume: 29, Issue:3

    Topics: Antipsychotic Agents; Aripiprazole; Bupropion; Central Nervous System Stimulants; Dextroamphetamine;

2008
Attention-deficit-hyperactivity disorder: an update.
    Pharmacotherapy, 2009, Volume: 29, Issue:6

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Amphetamine; Antidepressive Agents, Second-Generati

2009
Illicit methylphenidate use: a review of prevalence, availability, pharmacology, and consequences.
    Current drug abuse reviews, 2009, Volume: 2, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Prescriptions

2009
The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety.
    Neuropharmacology, 2009, Volume: 57, Issue:7-8

    Topics: Adrenergic Uptake Inhibitors; Amphetamine; Animals; Atomoxetine Hydrochloride; Attention Deficit Dis

2009
Safety of stimulant treatment in attention deficit hyperactivity disorder: Part I.
    Expert opinion on drug safety, 2009, Volume: 8, Issue:6

    Topics: Adolescent; Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste

2009
Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies.
    Annals of the New York Academy of Sciences, 2010, Volume: 1187

    Topics: Animals; Behavior Therapy; Benzhydryl Compounds; Bupropion; Central Nervous System Stimulants; Clini

2010
Methylphenidate-induced psychosis in adult attention-deficit/hyperactivity disorder: report of 3 new cases and review of the literature.
    Clinical neuropharmacology, 2010, Volume: 33, Issue:4

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous System Stimu

2010
[Methylphenidate: pharmacology, indication and potential of abuse].
    Nihon rinsho. Japanese journal of clinical medicine, 2010, Volume: 68, Issue:8

    Topics: Adult; Attention Deficit and Disruptive Behavior Disorders; Humans; Male; Methylphenidate; Narcoleps

2010
Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.
    CNS drugs, 2011, Volume: 25, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Delayed-Action Preparations; Diag

2011
Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.
    CNS drugs, 2011, Volume: 25, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Delayed-Action Preparations; Diag

2011
Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.
    CNS drugs, 2011, Volume: 25, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Delayed-Action Preparations; Diag

2011
Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis.
    CNS drugs, 2011, Volume: 25, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Comorbidity; Delayed-Action Preparations; Diag

2011
[Methylphenidate misuse].
    Praxis, 2012, Feb-29, Volume: 101, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Sectional St

2012
Comorbid attention deficit/hyperactivity disorder and substance use disorder: treatment considerations.
    Current drug abuse reviews, 2012, Volume: 5, Issue:3

    Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste

2012
Pharmacological and clinical dilemmas of prescribing in co-morbid adult attention-deficit/hyperactivity disorder and addiction.
    British journal of clinical pharmacology, 2014, Volume: 77, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hype

2014
Practitioner review: current best practice in the management of adverse events during treatment with ADHD medications in children and adolescents.
    Journal of child psychology and psychiatry, and allied disciplines, 2013, Volume: 54, Issue:3

    Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Blood Pressure

2013
The role of dopamine in motivation for food in humans: implications for obesity.
    Expert opinion on therapeutic targets, 2002, Volume: 6, Issue:5

    Topics: Animals; Appetite; Brain Chemistry; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonis

2002
Role of dopamine in the therapeutic and reinforcing effects of methylphenidate in humans: results from imaging studies.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2002, Volume: 12, Issue:6

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Brain; Dopamine; Dopamine Plasma Membrane Tr

2002
Methylphenidate and substance abuse: a review of pharmacology, animal, and clinical studies.
    Journal of attention disorders, 2002, Volume: 6 Suppl 1

    Topics: Administration, Oral; Animals; Central Nervous System Stimulants; Child; Humans; Longitudinal Studie

2002
Attention deficit hyperactivity disorder in sport: a review.
    International journal of sports medicine, 2003, Volume: 24, Issue:7

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clinical Trials as

2003
Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient.
    The Journal of clinical psychiatry, 2003, Volume: 64 Suppl 11

    Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimula

2003
Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD.
    The American journal of psychiatry, 2003, Volume: 160, Issue:11

    Topics: Attention Deficit Disorder with Hyperactivity; Brain; Cocaine; Delayed-Action Preparations; Dopamine

2003
Serum and brain concentrations of methylphenidate: implications for use and abuse.
    Neuroscience and biobehavioral reviews, 2003, Volume: 27, Issue:7

    Topics: Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Brain; Brain Chemis

2003
Methylphenidate: a review of its neuropharmacological, neuropsychological and adverse clinical effects.
    Human psychopharmacology, 2004, Volume: 19, Issue:3

    Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Behavior; Brain Injuries; Central Ner

2004
When the child with ADHD grows up.
    Australian family physician, 2004, Volume: 33, Issue:8

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2004
Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules.
    Neuropharmacology, 2004, Volume: 47 Suppl 1

    Topics: Aging; Animals; Behavior; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Chil

2004
Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse.
    Biological psychiatry, 2005, Jun-01, Volume: 57, Issue:11

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Disease M

2005
Adolescent substance use: brief interventions by emergency care providers.
    Pediatric emergency care, 2005, Volume: 21, Issue:11

    Topics: Adolescent; Adolescent Behavior; Attention Deficit Disorder with Hyperactivity; Chest Pain; Cocaine-

2005
Misuse of "study drugs:" prevalence, consequences, and implications for policy.
    Substance abuse treatment, prevention, and policy, 2006, Jun-09, Volume: 1

    Topics: Adolescent; Adult; Amphetamines; Cardiovascular Diseases; Central Nervous System Stimulants; Emotion

2006
The science of stimulant abuse.
    Pediatric annals, 2006, Volume: 35, Issue:8

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; De

2006
Nonmedical use of prescription stimulants among students.
    Pediatric annals, 2006, Volume: 35, Issue:8

    Topics: Adolescent; Adult; Central Nervous System Stimulants; Child; Female; Humans; Male; Methylphenidate;

2006
Attention deficit hyperactivity disorder across the lifespan: the child, adolescent, and adult.
    Disease-a-month : DM, 2007, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity;

2007
The consequences of attention-deficit/hyperactivity disorder in adults.
    Journal of psychiatric practice, 2007, Volume: 13, Issue:5

    Topics: Achievement; Adult; Age Factors; Amphetamine; Atomoxetine Hydrochloride; Attention Deficit Disorder

2007
Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2008, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst

2008
ADHD, substance use disorders, and psychostimulant treatment: current literature and treatment guidelines.
    Journal of attention disorders, 2008, Volume: 12, Issue:2

    Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child

2008
Attention deficit hyperactivity disorder and substance use disorders.
    Child and adolescent psychiatric clinics of North America, 2008, Volume: 17, Issue:2

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Bupropion; Central Nervous System Stimula

2008
Cardiac and vascular involvement in drug abuse.
    Seminars in roentgenology, 1983, Volume: 18, Issue:3

    Topics: Adult; Aneurysm, Infected; Arterial Occlusive Diseases; Arteriovenous Fistula; Cardiomyopathies; Car

1983
The spectrum of cocaine abuse and its treatment.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:12 Pt 2

    Topics: Ambulatory Care; Antidepressive Agents, Tricyclic; Behavior Therapy; Cocaine; Depressive Disorder; H

1984
Cocaine abuse: a review of current and experimental treatments.
    NIDA research monograph, 1984, Volume: 50

    Topics: Animals; Antidepressive Agents, Tricyclic; Cocaine; Humans; Lithium; Lithium Carbonate; Methylphenid

1984
The dual diagnosis of attention-deficit/hyperactivity disorder and substance abuse: case reports and literature review.
    The Journal of clinical psychiatry, 1995, Volume: 56, Issue:4

    Topics: Adult; Alcoholism; Attention Deficit Disorder with Hyperactivity; Comorbidity; Diagnosis, Dual (Psyc

1995
Cocaine addiction: hypothesis derived from imaging studies with PET.
    Journal of addictive diseases, 1996, Volume: 15, Issue:4

    Topics: Animals; Brain; Carbon Radioisotopes; Cocaine; Dopamine Uptake Inhibitors; Humans; Methylphenidate;

1996
Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association.
    JAMA, 1998, Apr-08, Volume: 279, Issue:14

    Topics: Adolescent; American Medical Association; Attention Deficit Disorder with Hyperactivity; Central Ner

1998
[Central nervous system stimulants and their potential risk of abuse in hyperkinetic disorders].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1999, Nov-10, Volume: 119, Issue:27

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Dext

1999
Emerging drugs of abuse in Connecticut.
    Connecticut medicine, 2000, Volume: 64, Issue:1

    Topics: Cannabis; Connecticut; Female; Humans; Incidence; Ketamine; Male; Methylphenidate; Risk Assessment;

2000
Psychostimulants in supportive care.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2000, Volume: 8, Issue:5

    Topics: Adult; Caffeine; Central Nervous System Stimulants; Child; Dextroamphetamine; Ephedrine; Humans; Men

2000
Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a review.
    Pharmacology, biochemistry, and behavior, 2001, Volume: 68, Issue:3

    Topics: Animals; Dopamine Uptake Inhibitors; Humans; Methylphenidate; Substance-Related Disorders

2001
Attention deficit hyperactivity disorder and substance use disorders: Is there a causal link?
    Addiction (Abingdon, England), 2001, Volume: 96, Issue:6

    Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste

2001
Abuse and toxicity of methylphenidate.
    Current opinion in pediatrics, 2002, Volume: 14, Issue:2

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child;

2002
Hyperkinetic children: the use of stimulant drugs evaluated.
    The American journal of orthopsychiatry, 1975, Volume: 45, Issue:1

    Topics: Achievement; Animals; Attention; Blood Pressure; Central Nervous System; Dextroamphetamine; Feeding

1975
[Psychotropic drug therapy in children].
    Fortschritte der Medizin, 1977, Sep-08, Volume: 95, Issue:33

    Topics: Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Autistic Disorder;

1977
Effects of psychostimulants on aggression.
    The Journal of nervous and mental disease, 1975, Volume: 160, Issue:2-1

    Topics: Adolescent; Aggression; Amphetamine; Animals; Child; Dextroamphetamine; Dogs; Dose-Response Relation

1975
Chronic cerebral effects of alcohol and drug abuse.
    The International journal of the addictions, 1975, Volume: 10, Issue:5

    Topics: Alcoholism; Amphetamines; Barbiturates; Brain Diseases; Cannabis; Cerebrovascular Disorders; Cocaine

1975
Addictiveness of central stimulants.
    Advances in alcohol & substance abuse, 1990, Volume: 9, Issue:1-2

    Topics: Amphetamines; Central Nervous System Stimulants; Cocaine; Euphoria; Humans; Methylphenidate; Substan

1990
Disseminated granulomatosis through a patent foramen ovale in an intravenous drug user with pulmonary hypertension.
    The American journal of forensic medicine and pathology, 1987, Volume: 8, Issue:4

    Topics: Adult; Heart Septum; Humans; Hydromorphone; Hypertension, Pulmonary; Lymphomatoid Granulomatosis; Ma

1987
Substance abuse in adolescents: diagnostic issues derived from studies of attention deficit disorder with hyperactivity.
    NIDA research monograph, 1988, Volume: 77

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Humans; Male; Methylphenidate; Pro

1988
Chronic neuropharmacology of cocaine: progress in pharmacotherapy.
    The Journal of clinical psychiatry, 1988, Volume: 49 Suppl

    Topics: Amphetamine; Animals; Behavior, Animal; Cocaine; Dopamine; Humans; Methylphenidate; Psychotherapy; R

1988
Myocardial injury associated with polysubstance abuse.
    American heart journal, 1988, Volume: 115, Issue:3

    Topics: Adult; Amphetamine; Cardiomyopathies; Cocaine; Drug Synergism; Electrocardiography; Female; Heroin;

1988
Treating problem children with stimulant drugs.
    The New England journal of medicine, 1973, Aug-23, Volume: 289, Issue:8

    Topics: Adult; Amphetamine; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants

1973
Eikenella corrodens, a recently recognized pathogen: infections in medical-surgical patients and in association with methylphenidate abuse.
    Medicine, 1974, Volume: 53, Issue:5

    Topics: Abscess; Adolescent; Adult; Aged; Ampicillin; Bacteriological Techniques; Bacteroides; Bacteroides I

1974
Genetic issues in the syndrome of minimal brain dysfunction.
    Seminars in psychiatry, 1973, Volume: 5, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Dextroamphetamine; Diseases in Twins; Female; Humans;

1973

Trials

32 trials available for methylphenidate and Chemical Dependence

ArticleYear
Challenging expectancies to prevent nonmedical prescription stimulant use: a randomized, controlled trial.
    Drug and alcohol dependence, 2013, Sep-01, Volume: 132, Issue:1-2

    Topics: Adolescent; Alcoholism; Central Nervous System Stimulants; Data Interpretation, Statistical; Female;

2013
An N-of-1 trial as an individualized withdrawal treatment approach to psychological methylphenidate dependence.
    Psychotherapy and psychosomatics, 2014, Volume: 83, Issue:6

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Over

2014
An application of analyzing the trajectories of two disorders: A parallel piecewise growth model of substance use and attention-deficit/hyperactivity disorder.
    Experimental and clinical psychopharmacology, 2015, Volume: 23, Issue:6

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognit

2015
Assessment of human abuse potential of dasotraline compared to methylphenidate and placebo in recreational stimulant users.
    Drug and alcohol dependence, 2016, Feb-01, Volume: 159

    Topics: 1-Naphthylamine; Adult; Central Nervous System Stimulants; Cross-Over Studies; Dose-Response Relatio

2016
Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD).
    Psychopharmacology, 2009, Volume: 204, Issue:1

    Topics: Administration, Oral; Adult; Area Under Curve; Attention Deficit Disorder with Hyperactivity; Centra

2009
Molecular imaging genetics of methylphenidate response in ADHD and substance use comorbidity.
    Synapse (New York, N.Y.), 2011, Volume: 65, Issue:2

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Brain; Brain Mapping; Comorbidity; Dopami

2011
Cigarette and cannabis use trajectories among adolescents in treatment for attention-deficit/hyperactivity disorder and substance use disorders.
    Drug and alcohol dependence, 2011, Sep-01, Volume: 117, Issue:2-3

    Topics: Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous Sys

2011
Randomized controlled trial of osmotic-release methylphenidate with cognitive-behavioral therapy in adolescents with attention-deficit/hyperactivity disorder and substance use disorders.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2011, Volume: 50, Issue:9

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognit

2011
Major depression and treatment response in adolescents with ADHD and substance use disorder.
    Drug and alcohol dependence, 2012, Jan-01, Volume: 120, Issue:1-3

    Topics: Adolescent; Alcohol-Related Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervou

2012
Subjective effects, misuse, and adverse effects of osmotic-release methylphenidate treatment in adolescent substance abusers with attention-deficit/hyperactivity disorder.
    Journal of child and adolescent psychopharmacology, 2011, Volume: 21, Issue:5

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2011
Methylphenidate treatment of adult male prison inmates with attention-deficit hyperactivity disorder: randomised double-blind placebo-controlled trial with open-label extension.
    The British journal of psychiatry : the journal of mental science, 2012, Volume: 200, Issue:1

    Topics: Adult; Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous System S

2012
Oppositional defiant disorder in adults with ADHD.
    Journal of attention disorders, 2013, Volume: 17, Issue:2

    Topics: Adult; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperact

2013
Importance of pharmacokinetic profile and timing of coadministration of short- and long-acting formulations of methylphenidate on patterns of subjective responses and abuse potential.
    Postgraduate medicine, 2012, Volume: 124, Issue:1

    Topics: Adolescent; Adult; Attitude; Central Nervous System Stimulants; Cross-Over Studies; Delayed-Action P

2012
Predictors of treatment response in adolescents with comorbid substance use disorder and attention-deficit/hyperactivity disorder.
    Journal of substance abuse treatment, 2013, Volume: 44, Issue:2

    Topics: Administration, Oral; Adolescent; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; C

2013
Do Stimulants Reduce the Risk for Alcohol and Substance Use in Youth With ADHD? A Secondary Analysis of a Prospective, 24-Month Open-Label Study of Osmotic-Release Methylphenidate.
    Journal of attention disorders, 2017, Volume: 21, Issue:1

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child;

2017
Effects of methylphenidate on impulsive choice in adult humans.
    Psychopharmacology, 2003, Volume: 170, Issue:4

    Topics: Adolescent; Adult; Analysis of Variance; Central Nervous System Stimulants; Choice Behavior; Humans;

2003
Does stimulant treatment place children at risk for adult substance abuse? A controlled, prospective follow-up study.
    Journal of child and adolescent psychopharmacology, 2003,Fall, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste

2003
Assessing methylphenidate preference in ADHD patients using a choice procedure.
    Psychopharmacology, 2004, Volume: 175, Issue:4

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2004
Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans.
    Journal of psychopharmacology (Oxford, England), 2004, Volume: 18, Issue:4

    Topics: Adult; Central Nervous System Stimulants; Dextroamphetamine; Dose-Response Relationship, Drug; Doubl

2004
A controlled trial of methylphenidate in adults with attention deficit/hyperactivity disorder and substance use disorders.
    Addiction (Abingdon, England), 2005, Volume: 100, Issue:12

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Over

2005
Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects.
    NeuroImage, 2006, Oct-01, Volume: 32, Issue:4

    Topics: Adult; Blood Pressure; Brain; Brain Chemistry; Central Nervous System Stimulants; Dopamine; Dopamine

2006
Preventive effects of treatment of disruptive behavior disorder in middle childhood on substance use and delinquent behavior.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2007, Volume: 46, Issue:1

    Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Central Nervous System Stimulants;

2007
Do formulation differences alter abuse liability of methylphenidate? A placebo-controlled, randomized, double-blind, crossover study in recreational drug users.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:5

    Topics: Adult; Behavior, Addictive; Central Nervous System Stimulants; Cross-Over Studies; Delayed-Action Pr

2007
Assessment of pharmacokinetics and pharmacodynamic effects related to abuse potential of a unique oral osmotic-controlled extended-release methylphenidate formulation in humans.
    Journal of clinical pharmacology, 2007, Volume: 47, Issue:12

    Topics: Administration, Oral; Adolescent; Adult; Amphetamine; Area Under Curve; Central Nervous System Stimu

2007
A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:3

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2008
Abuse liability assessment of atomoxetine in a drug-abusing population.
    Drug and alcohol dependence, 2008, May-01, Volume: 95, Issue:1-2

    Topics: Adrenergic Uptake Inhibitors; Adult; Arousal; Atomoxetine Hydrochloride; Central Nervous System Stim

2008
Methylphenidate effects on symptoms of attention deficit disorder in adults.
    Archives of general psychiatry, 1984, Volume: 41, Issue:11

    Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Clinical Trial

1984
Sustained-release methylphenidate for cognitive impairment in HIV-1-infected drug abusers: a pilot study.
    The Journal of neuropsychiatry and clinical neurosciences, 1997,Winter, Volume: 9, Issue:1

    Topics: Adult; Attention; Central Nervous System Stimulants; Cognition Disorders; Delayed-Action Preparation

1997
An evaluation of the abuse potential of modafinil using methylphenidate as a reference.
    Journal of psychopharmacology (Oxford, England), 2000, Volume: 14, Issue:1

    Topics: Adult; Appetite; Arousal; Benzhydryl Compounds; Central Nervous System Stimulants; Cross-Over Studie

2000
Comparison of the subjective, physiological, and psychomotor effects of atomoxetine and methylphenidate in light drug users.
    Drug and alcohol dependence, 2002, Jul-01, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Analysis of Variance; Atomoxetine Hydrochloride; Blood Pressure; Double-Blind Met

2002
The effect of methylphenidate on serum growth hormone: influence of antipsychotic drugs and diagnosis.
    Archives of general psychiatry, 1978, Volume: 35, Issue:11

    Topics: Adjustment Disorders; Adolescent; Adult; Alcoholism; Antipsychotic Agents; Bipolar Disorder; Blood P

1978
Diagnosis and treatment of minimal brain dysfunction in adults: a preliminary report.
    Archives of general psychiatry, 1976, Volume: 33, Issue:12

    Topics: Adult; Alcoholism; Antisocial Personality Disorder; Anxiety; Attention Deficit Disorder with Hyperac

1976

Other Studies

252 other studies available for methylphenidate and Chemical Dependence

ArticleYear
Plasma concentrations of methylphenidate enantiomers in adults with ADHD and substance use disorder, with focus on high doses and relationship to carboxylesterase activity.
    Basic & clinical pharmacology & toxicology, 2022, Volume: 130, Issue:4

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Carboxylic Ester Hydrolases; Central Nervous S

2022
[Trend in medicines use for attention deficit hyperactivity disorder in children and adolescents (2010-2019).]
    Revista espanola de salud publica, 2022, Mar-23, Volume: 96

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2022
Effects of Early Life Exposure to Sex Hormones on Neurochemical and Behavioral Responses to Psychostimulants in Adulthood: Implications in Drug Addiction.
    International journal of molecular sciences, 2022, Jun-12, Volume: 23, Issue:12

    Topics: Amphetamine; Animals; Central Nervous System Stimulants; Dopamine; Estradiol; Female; Male; Methylph

2022
Time-dependent affective disturbances in abstinent patients with methylphenidate use disorder.
    BMC psychiatry, 2022, 08-22, Volume: 22, Issue:1

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans

2022
[ADHD medication to improve academic performance?]
    Nederlands tijdschrift voor geneeskunde, 2023, 01-03, Volume: 167

    Topics: Academic Performance; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan

2023
Concomitant Drug Use among Opioid-Dependent Patients with and without Attention Deficit Hyperactivity Disorder: Does Methylphenidate Merit a Trial?
    European addiction research, 2023, Volume: 29, Issue:5

    Topics: Amphetamine; Analgesics, Opioid; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst

2023
The Adverse Effects and Nonmedical Use of Methylphenidate Before and After the Outbreak of COVID-19: Machine Learning Analysis.
    Journal of medical Internet research, 2023, 08-16, Volume: 25

    Topics: Attention Deficit Disorder with Hyperactivity; Bayes Theorem; Central Nervous System Stimulants; COV

2023
4-Fluoromethylphenidate: Fatal Intoxication Involving a Previously Unreported Novel Psychoactive Substance in the USA.
    Journal of analytical toxicology, 2019, Sep-10, Volume: 43, Issue:8

    Topics: Adult; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Fatal Outcome; Foren

2019
Psychostimulant Use for Neuroenhancement (Smart Drugs) among College Students in Brazil.
    Substance use & misuse, 2020, Volume: 55, Issue:4

    Topics: Brazil; Central Nervous System Stimulants; Cognition; Cross-Sectional Studies; Humans; Methylphenida

2020
Students' stimulant use for cognitive enhancement: A deliberate choice rather than an emotional response to a given situation.
    Drug and alcohol dependence, 2021, 01-01, Volume: 218

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognition;

2021
Cannabidiol attenuated the maintenance and reinstatement of extinguished methylphenidate-induced conditioned place preference in rats.
    Brain research bulletin, 2021, Volume: 166

    Topics: Animals; Cannabidiol; Central Nervous System Stimulants; Conditioning, Psychological; Extinction, Ps

2021
Use of Cognitive Enhancers by Portuguese Medical Students: Do Academic Challenges Matter?
    Acta medica portuguesa, 2022, Apr-01, Volume: 35, Issue:4

    Topics: Central Nervous System Stimulants; Humans; Methylphenidate; Nootropic Agents; Portugal; Students, Me

2022
Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward.
    The Journal of clinical investigation, 2021, 09-15, Volume: 131, Issue:18

    Topics: Actigraphy; Adult; Central Nervous System Stimulants; Circadian Rhythm; Corpus Striatum; Female; Hum

2021
Changes in medical use of central nervous system stimulants among US adults, 2013 and 2018: a cross-sectional study.
    BMJ open, 2021, 08-13, Volume: 11, Issue:8

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Secti

2021
Long-term effects of stimulant exposure on cerebral blood flow response to methylphenidate and behavior in attention-deficit hyperactivity disorder.
    Brain imaging and behavior, 2018, Volume: 12, Issue:2

    Topics: Adult; Affect; Age Factors; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous Sy

2018
Intoxication caused by new psychostimulants: analytical methods to disclose acute and chronic use of benzofurans and ethylphenidate.
    International journal of legal medicine, 2017, Volume: 131, Issue:6

    Topics: Benzofurans; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Hair; Human

2017
Methylphenidate doses in Attention Deficit/Hyperactivity Disorder and comorbid substance use disorders.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017, Volume: 27, Issue:11

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2017
International Consensus Statement on Screening, Diagnosis and Treatment of Substance Use Disorder Patients with Comorbid Attention Deficit/Hyperactivity Disorder.
    European addiction research, 2018, Volume: 24, Issue:1

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity

2018
Simultaneous determination of methylphenidate and ritalinic acid in hair using LC-MS/MS.
    Forensic science international, 2019, Volume: 294

    Topics: Central Nervous System Stimulants; Chromatography, Liquid; Hair; Humans; Limit of Detection; Methylp

2019
Methylphenidate effects on processing speed in a clinical sample of adults with ADHD and substance use disorder: a pilot study.
    Nordic journal of psychiatry, 2019, Volume: 73, Issue:2

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2019
Non-Medical Use of Prescription Stimulants for Treatment of Attention Disorders by University Students: Characteristics and Associations.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, May-21, Volume: 25

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cognition D

2019
Emergency department presentations related to abuse of prescription and over-the-counter drugs in Switzerland: time trends, sex and age distribution.
    Swiss medical weekly, 2019, Jul-15, Volume: 149

    Topics: Adolescent; Adult; Age Distribution; Aged; Alcohol Drinking; Antidepressive Agents; Benzodiazepines;

2019
Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors.
    ACS chemical neuroscience, 2019, 09-18, Volume: 10, Issue:9

    Topics: Alkaloids; Central Nervous System Stimulants; Dopamine Plasma Membrane Transport Proteins; Dopamine

2019
Methylphenidate: abuse in Europe.
    Prescrire international, 2013, Volume: 22, Issue:135

    Topics: Central Nervous System Stimulants; Europe; Humans; Methylphenidate; Substance-Related Disorders

2013
Prohibition or coffee shops: regulation of amphetamine and methylphenidate for enhancement use by healthy adults.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Administration, Oral; Adult; Amphetamine; Amphetamines; Central Nervous System Stimulants; Cognition

2013
Enhancement policy and the value of information.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
Constraints on regulatory options for putatively cognitive enhancing drugs.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
There may be costs to failing to enhance, as well as to enhancing.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
Some first steps toward responsible use of cognitive-enhancing drugs by the healthy.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
How research on stakeholder perspectives can inform policy on cognitive enhancement.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
Moving beyond methylphenidate and amphetamine: the ethics of a better "smart drug".
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
Regulating methylphenidate: enhancing cognition and social inequality.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
The indirect psychological costs of cognitive enhancement.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
An argument for permitting amphetamines and instant-release methylphenidate.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
Tobacco: prohibition, coffee shops, or discouragement?
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
A liberal consequentialist approach to regulation of cognitive enhancers.
    The American journal of bioethics : AJOB, 2013, Volume: 13, Issue:7

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2013
Nonmedical use of prescription ADHD stimulant medications among adults in a substance abuse treatment population: early findings from the NAVIPPRO surveillance system.
    Journal of attention disorders, 2015, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Attention Deficit Disorder with Hyperactivity; Cen

2015
ADHD, stimulant treatment in childhood and subsequent substance abuse in adulthood - a naturalistic long-term follow-up study.
    Addictive behaviors, 2014, Volume: 39, Issue:1

    Topics: Adolescent; Adult; Age Factors; Alcoholism; Attention Deficit Disorder with Hyperactivity; Central N

2014
Substance use disorders in association with attention-deficit/hyperactivity disorder, co-morbid mental disorders, and medication in a nationwide sample.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:2

    Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Attention Deficit Disorder with Hype

2014
Response to open peer commentaries on "prohibition or coffee shops: regulation of amphetamine and methylphenidate for enhancement use by healthy adults".
    The American journal of bioethics : AJOB, 2014, Volume: 14, Issue:1

    Topics: Amphetamine; Central Nervous System Stimulants; Drug and Narcotic Control; Humans; Methylphenidate;

2014
A European community pharmacy-based survey to investigate patterns of prescription fraud through identification of falsified prescriptions.
    European addiction research, 2014, Volume: 20, Issue:4

    Topics: Analgesics, Opioid; Belgium; Benzodiazepines; Buprenorphine; Central Nervous System Stimulants; Cros

2014
Psychiatric Comorbidity at the Time of Diagnosis in Adults With ADHD: The CAT Study.
    Journal of attention disorders, 2016, Volume: 20, Issue:12

    Topics: Adult; Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Comorbidity; Cross-Sectiona

2016
Life context of pharmacological academic performance enhancement among university students--a qualitative approach.
    BMC medical ethics, 2014, Mar-07, Volume: 15

    Topics: Adult; Amphetamines; Central Nervous System Stimulants; Cognition; Educational Status; Female; Human

2014
Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration.
    Neuropharmacology, 2014, Volume: 82

    Topics: Amphetamine; Animals; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response

2014
Characterization of four new designer drugs, 5-chloro-NNEI, NNEI indazole analog, α-PHPP and α-POP, with 11 newly distributed designer drugs in illegal products.
    Forensic science international, 2014, Volume: 243

    Topics: Alkaloids; Cannabinoids; Central Nervous System Stimulants; Designer Drugs; Heterocyclic Compounds,

2014
Methylphenidate misuse in adult patients and the impact of therapeutic use.
    Human & experimental toxicology, 2015, Volume: 34, Issue:5

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Data Interp

2015
Intravenous methylphenidate: an unusual way to provoke ST-elevation myocardial infarction.
    The American journal of emergency medicine, 2015, Volume: 33, Issue:2

    Topics: Adult; Central Nervous System Stimulants; Electrocardiography; Emergency Service, Hospital; Heart; H

2015
Injection of crushed tablets--a prospective observational study.
    Clinical toxicology (Philadelphia, Pa.), 2014, Volume: 52, Issue:9

    Topics: Adolescent; Adult; Azabicyclo Compounds; Benzodiazepines; Buprenorphine; C-Reactive Protein; Female;

2014
Intention and willingness in understanding Ritalin misuse among Iranian medical college students: a cross-sectional study.
    Global journal of health science, 2014, Jun-30, Volume: 6, Issue:6

    Topics: Cross-Sectional Studies; Drug Users; Female; Humans; Intention; Iran; Male; Methylphenidate; Student

2014
Prevalence, Patient Characteristics, and Pharmacological Treatment of Children, Adolescents, and Adults Diagnosed With ADHD in Sweden.
    Journal of attention disorders, 2018, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Age Distribution; Anxiety Disorders; Attention Deficit Disorder with Hyperactivit

2018
Everyday drug diversions: a qualitative study of the illicit exchange and non-medical use of prescription stimulants on a university campus.
    Social science & medicine (1982), 2015, Volume: 131

    Topics: Adolescent; Amphetamines; Central Nervous System Stimulants; Deception; Drug Trafficking; Female; Hu

2015
Differences in methylphenidate abuse rates among methadone maintenance treatment patients in two clinics.
    Journal of substance abuse treatment, 2015, Volume: 54

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Central Nervous System Stimul

2015
Differences in abuse potential of ADHD drugs measured by contrasting poison centre and therapeutic use data.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:4

    Topics: Adolescent; Adult; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Central

2015
Nopaine no gain: recreational ethylphenidate toxicity.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:5

    Topics: Adult; Anxiety; Arrhythmias, Cardiac; Central Nervous System; Central Nervous System Stimulants; Chr

2015
Patterns of concurrent substance use among adolescent nonmedical ADHD stimulant users.
    Addictive behaviors, 2015, Volume: 49

    Topics: Adolescent; Amphetamines; Analgesics, Opioid; Central Nervous System Stimulants; Child; Cocaine-Rela

2015
Dependence on Internet-Purchased Ethylphenidate.
    Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:4

    Topics: Humans; Internet; Male; Methylphenidate; Substance-Related Disorders; Young Adult

2015
Reflections on Addiction in Students Using Stimulants for Neuroenhancement: A Preliminary Interview Study.
    BioMed research international, 2015, Volume: 2015

    Topics: Adult; Amphetamines; Behavior, Addictive; Central Nervous System Stimulants; Female; Health Surveys;

2015
Prevalence of cognitive enhancer use among New Zealand tertiary students.
    Drug and alcohol review, 2016, Volume: 35, Issue:3

    Topics: Adult; Amphetamines; Benzhydryl Compounds; Female; Humans; Male; Methylphenidate; Modafinil; Motivat

2016
A review of ethylphenidate in deaths in east and west Scotland.
    Forensic science international, 2015, Volume: 257

    Topics: Adult; Cause of Death; Central Nervous System Stimulants; Female; Humans; Male; Methylphenidate; Mid

2015
Smart drugs: A dose of intelligence.
    Nature, 2016, Mar-03, Volume: 531, Issue:7592

    Topics: Aging; Amphetamines; Animals; Benzhydryl Compounds; Biomedical Enhancement; Caffeine; Child; Cogniti

2016
ADHD and psychostimulants - overdiagnosis and overprescription.
    The Medical journal of Australia, 2016, Mar-07, Volume: 204, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Overdose; Fem

2016
ADHD medication overdose and misuse: the NSW Poisons Information Centre experience, 2004-2014.
    The Medical journal of Australia, 2016, Mar-07, Volume: 204, Issue:4

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2016
Factors Associated With Adherence to Methylphenidate Treatment in Adult Patients With Attention-Deficit/Hyperactivity Disorder and Substance Use Disorders.
    Journal of clinical psychopharmacology, 2016, Volume: 36, Issue:3

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants;

2016
Involvement of AMPA/kainate and GABAA receptors in topiramate neuroprotective effects against methylphenidate abuse sequels involving oxidative stress and inflammation in rat isolated hippocampus.
    European journal of pharmacology, 2016, Aug-05, Volume: 784

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Fructose; Glutathione Disulfide

2016
The Genetic and Environmental Association Between Parental Monitoring and Risk of Cannabis, Stimulants, and Cocaine Initiation in a Sample of Male Twins: Does Parenting Matter?
    Twin research and human genetics : the official journal of the International Society for Twin Studies, 2016, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Child; Cocaine-Related Disorders; Humans; Male; Marijuana Abuse; Methylphenidate;

2016
Imitations and Transformations: On Side Effects of the ADHD Epidemic.
    Medical anthropology, 2017, Volume: 36, Issue:3

    Topics: Adult; Anthropology, Medical; Attention Deficit Disorder with Hyperactivity; Central Nervous System

2017
Assessing prescription drug abuse using functional principal component analysis (FPCA) of wastewater data.
    Pharmacoepidemiology and drug safety, 2017, Volume: 26, Issue:3

    Topics: Environmental Monitoring; Humans; Methadone; Methylphenidate; Models, Theoretical; Norway; Oxazepam;

2017
Sensitivity of Quantitative Signal Detection in Regards to Pharmacological Neuroenhancement.
    International journal of molecular sciences, 2017, Jan-05, Volume: 18, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adverse Drug Reaction Reporting Systems; Atomoxetine Hydrochloride; Au

2017
Increasing use of stimulants warns of potential abuse.
    Nature, 2008, May-29, Volume: 453, Issue:7195

    Topics: Adult; Amphetamine; Central Nervous System Stimulants; Drug Prescriptions; Humans; Methylphenidate;

2008
Impulsive choice and environmental enrichment: effects of d-amphetamine and methylphenidate.
    Behavioural brain research, 2008, Nov-03, Volume: 193, Issue:1

    Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Choice Behavior; Conditio

2008
Abuse of medications employed for the treatment of ADHD: results from a large-scale community survey.
    Medscape journal of medicine, 2008, May-07, Volume: 10, Issue:5

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Data C

2008
NICE guidance on ADHD. Diversion and abuse of methylphenidate in light of new guidance.
    BMJ (Clinical research ed.), 2008, Oct-28, Volume: 337

    Topics: Adult; Central Nervous System Stimulants; Child; Drug Prescriptions; Humans; Methylphenidate; Practi

2008
Nicotinic receptors differentially modulate the induction and expression of behavioral sensitization to methylphenidate in rats.
    Psychopharmacology, 2009, Volume: 204, Issue:3

    Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Dihydro-beta-Erythroidine; Dose-Respon

2009
[Drug dependence and methylphenidate].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2008, Volume: 110, Issue:10

    Topics: Attention Deficit Disorder with Hyperactivity; Dopamine Uptake Inhibitors; Humans; Methylphenidate;

2008
Juvenile methylphenidate exposure and factors that influence incentive processing.
    Developmental neuroscience, 2009, Volume: 31, Issue:1-2

    Topics: Administration, Oral; Aging; Animals; Central Nervous System Stimulants; Conditioning, Operant; Fema

2009
Case histories in pharmaceutical risk management.
    Drug and alcohol dependence, 2009, Dec-01, Volume: 105 Suppl 1

    Topics: Buprenorphine; Buprenorphine, Naloxone Drug Combination; Dextroamphetamine; Drug and Narcotic Contro

2009
Prescription stimulant expectancies in recreational and medical users: results from a preliminary expectancy questionnaire.
    Substance use & misuse, 2009, Volume: 44, Issue:11

    Topics: Adolescent; Adult; Amphetamines; Central Nervous System; Cluster Analysis; Female; Humans; Internet;

2009
Central stimulants in the treatment of attention-deficit hyperactivity disorder (ADHD) in children and adolescents. A naturalistic study of the prescription in Sweden, 1977-2007.
    Nordic journal of psychiatry, 2009, Volume: 63, Issue:6

    Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Amphetamine; Attention Deficit Disorder with Hy

2009
Methods of recruiting adolescents with psychiatric and substance use disorders for a clinical trial.
    The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:5

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Clinical Trials as Topic; Cognitive Behav

2009
[Bipolar disorders as co-morbidity in childhood and adolescence--underdiagnosed or overinterpreted? Therapy of a 14-year-old boy with hyperkinetic conduct disorder and hypomania].
    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie, 2010, Volume: 38, Issue:2

    Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; A

2010
Dispositional, ecological and biological influences on adolescent tranquilizer, Ritalin, and narcotics misuse.
    Journal of adolescence, 2011, Volume: 34, Issue:4

    Topics: Adolescent; Child; Dopamine Uptake Inhibitors; Female; Humans; Male; Methylphenidate; Opioid-Related

2011
Illicit methylphenidate use among Iranian medical students: prevalence and knowledge.
    Drug design, development and therapy, 2011, Feb-03, Volume: 5

    Topics: Adolescent; Adult; Age Factors; Central Nervous System Stimulants; Female; Health Knowledge, Attitud

2011
Comparison of the effects of methamphetamine, bupropion, and methylphenidate on the self-administration of methamphetamine by rhesus monkeys.
    Experimental and clinical psychopharmacology, 2011, Volume: 19, Issue:1

    Topics: Animals; Bupropion; Central Nervous System Stimulants; Conditioning, Operant; Dopamine Uptake Inhibi

2011
The nonmedical use of prescription stimulants among dental and dental hygiene students.
    Journal of dental education, 2011, Volume: 75, Issue:3

    Topics: Adolescent; Adult; Amphetamines; Attention; Attention Deficit Disorder with Hyperactivity; Attitude

2011
Patterns of methylphenidate use and assessment of its abuse and diversion in two French administrative areas using a proxy of deviant behaviour determined from a reimbursement database: main trends from 2005 to 2008.
    CNS drugs, 2011, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Attention Deficit Disorder with Hyperactivity; Central N

2011
Characteristics of college students with attention-deficit hyperactivity disorder symptoms who misuse their medications.
    Journal of American college health : J of ACH, 2011, Volume: 59, Issue:5

    Topics: Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Como

2011
Severe toxicity due to injected but not oral or nasal abuse of methylphenidate tablets.
    Swiss medical weekly, 2011, Volume: 141

    Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Central Nervous System Stimulan

2011
Caveat emptor, venditor, et praescribor: legal liability associated with methyplenidate hydrochloride (MPH) use by postsecondary students.
    Health law journal, 2010, Volume: 18

    Topics: Adolescent; Central Nervous System Stimulants; Humans; Liability, Legal; Methylphenidate; Students;

2010
The use of prescription stimulants to enhance academic performance among college students in health care programs.
    The journal of physician assistant education : the official journal of the Physician Assistant Education Association, 2011, Volume: 22, Issue:4

    Topics: Adolescent; Adult; Amphetamine-Related Disorders; Amphetamines; Central Nervous System Stimulants; C

2011
[Characteristics of university students using stimulants for cognitive enhancement: a pilot study].
    Psychiatrische Praxis, 2012, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Alcoholism; Amphetamines; Case-Control Studies; Central Nervous System Stimulants

2012
[Brain doping. With smart pills becoming the perfect human being].
    Krankenpflege. Soins infirmiers, 2012, Volume: 105, Issue:2

    Topics: Achievement; Adolescent; Adult; Benzhydryl Compounds; Brain; Central Nervous System Stimulants; Chil

2012
[Less fast, less far, less often].
    Krankenpflege. Soins infirmiers, 2012, Volume: 105, Issue:2

    Topics: Achievement; Activities of Daily Living; Central Nervous System Stimulants; Doping in Sports; Humans

2012
[Methylphenidate induced ST elevation acute myocardial infarction].
    Ugeskrift for laeger, 2012, Mar-05, Volume: 174, Issue:10

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Coronary Vasospasm

2012
Is the non-medical use of prescription stimulants a problem in Australia?
    The Medical journal of Australia, 2012, Aug-06, Volume: 197, Issue:3

    Topics: Amphetamine-Related Disorders; Australia; Central Nervous System Stimulants; Humans; Methylphenidate

2012
[The medical treatment of attention deficit hyperactivity disorder (ADHD) with amphetamines in children and adolescents].
    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie, 2012, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervo

2012
Methylphenidate: abuse and addiction.
    Prescrire international, 2012, Volume: 21, Issue:131

    Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste

2012
Nonmedical Use and Diversion of ADHD Stimulants Among U.S. Adults Ages 18-49: A National Internet Survey.
    Journal of attention disorders, 2015, Volume: 19, Issue:7

    Topics: Adult; Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulant

2015
Attempted abuse of concerta.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:7

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Delayed-Action Preparations; Diagnosis, D

2002
An unlikely vice: Ritalin.
    Advance for nurse practitioners, 2001, Volume: 9, Issue:2

    Topics: Attention; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans;

2001
Oral methylphenidate-alcohol co-abuse.
    Journal of clinical psychopharmacology, 2002, Volume: 22, Issue:6

    Topics: Administration, Oral; Adult; Alcoholism; Central Nervous System Stimulants; Comorbidity; Female; Hum

2002
Poison centers' experience with methylphenidate abuse in pre-teens and adolescents.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2003, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Child; Female; Humans; Hypertension; Male; Methylphenidate; Poison Control Center

2003
[Off-label use: the case of methylphenidate (Ritalin)].
    Der Nervenarzt, 2002, Volume: 73, Issue:12

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Drug Labeli

2002
Is there stimulant sensitivity in children?
    Journal of attention disorders, 2002, Volume: 6 Suppl 1

    Topics: Adolescent; Adult; Animals; Arousal; Attention Deficit Disorder with Hyperactivity; Central Nervous

2002
Illicit methylphenidate use in an undergraduate student sample: prevalence and risk factors.
    Pharmacotherapy, 2003, Volume: 23, Issue:5

    Topics: Alcoholism; Central Nervous System Stimulants; Data Collection; Female; Humans; Illicit Drugs; Inter

2003
Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential.
    Psychopharmacology, 2003, Volume: 169, Issue:2

    Topics: Animals; Atomoxetine Hydrochloride; Attention; Caffeine; Cognition; Cognition Disorders; Color Perce

2003
Cognitive enhancement raises ethical concerns. Academics urge pre-emptive debate on neurotechnologies.
    Lancet (London, England), 2003, Jul-12, Volume: 362, Issue:9378

    Topics: Central Nervous System Stimulants; Cognition; Ethics, Medical; Humans; Methylphenidate; Students; Su

2003
AMBULATORY WITHDRAWAL TREATMENT OF HEROIN ADDICTS.
    New York state journal of medicine, 1964, Jul-15, Volume: 64

    Topics: Chloral Hydrate; Chlorpromazine; Drug Therapy; Glutethimide; Heroin; Humans; Meprobamate; Methylphen

1964
[Methylphenidylacetate addiction].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1960, May-01, Volume: 80

    Topics: Humans; Methylphenidate; Substance-Related Disorders

1960
Is ritalin an addiction-producing drug?
    Diseases of the nervous system, 1960, Volume: 21

    Topics: Behavior, Addictive; Humans; Methylphenidate; Substance-Related Disorders

1960
[On the abuse of Ritalin].
    Ugeskrift for laeger, 1961, Sep-15, Volume: 123

    Topics: Humans; Mental Disorders; Methylphenidate; Substance-Related Disorders

1961
[On the problem of methylphenidylacetate addiction].
    Archiv fur Toxikologie, 1961, Volume: 19

    Topics: Behavior, Addictive; Humans; Methylphenidate; Substance-Related Disorders

1961
Urinary screening for methylphenidate (Ritalin) abuse: a comparison of liquid chromatography-tandem mass spectrometry, gas chromatography-mass spectrometry, and immunoassay methods.
    Clinical biochemistry, 2004, Volume: 37, Issue:3

    Topics: Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Hum

2004
Lacunar stroke associated with methylphenidate abuse.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2004, Volume: 31, Issue:1

    Topics: Adult; Brain Infarction; Humans; Male; Methylphenidate; Substance-Related Disorders

2004
Drug dependence and addiction, III: Expectation and brain function in drug abuse.
    The American journal of psychiatry, 2004, Volume: 161, Issue:4

    Topics: Behavior, Addictive; Brain; Central Nervous System Stimulants; Cocaine-Related Disorders; Glucose; H

2004
An update on attention deficit disorder.
    The Harvard mental health letter, 2004, Volume: 20, Issue:11

    Topics: Adult; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Ch

2004
Increased psychotropic drug consumption by children in the Netherlands during 1995-2001 is caused by increased use of methylphenidate by boys.
    European journal of clinical pharmacology, 2004, Volume: 60, Issue:5

    Topics: Adolescent; Central Nervous System Stimulants; Child; Child, Preschool; Databases, Factual; Female;

2004
Prevalence and characteristics of adolescents patients with co-occurring ADHD and substance dependence.
    Journal of addictive diseases, 2004, Volume: 23, Issue:4

    Topics: Adolescent; Adolescent Behavior; Attention Deficit Disorder with Hyperactivity; Central Nervous Syst

2004
Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy

2005
Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey.
    Addiction (Abingdon, England), 2005, Volume: 100, Issue:1

    Topics: Adult; Amphetamines; Central Nervous System Stimulants; Dextroamphetamine; Female; Humans; Male; Met

2005
[Caffeine, cannabis and cocaine: from automedication to 'automutilation' in adults with ADHD].
    Nederlands tijdschrift voor geneeskunde, 2004, Dec-25, Volume: 148, Issue:52

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System Stimulants; C

2004
Treating adolescent girls and women with ADHD: gender-specific issues.
    Journal of clinical psychology, 2005, Volume: 61, Issue:5

    Topics: Adolescent; Adult; Age Factors; Amphetamine; Anxiety Disorders; Attention Deficit Disorder with Hype

2005
Characteristics of methylphenidate misuse in a university student sample.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2005, Volume: 50, Issue:8

    Topics: Adolescent; Adult; Alcoholism; Attention; Central Nervous System Stimulants; Comorbidity; Cross-Sect

2005
Stimulant medications: how to minimize their reinforcing effects?
    The American journal of psychiatry, 2006, Volume: 163, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Behavior, Addictive; Brain; Central Nervous System St

2006
Methylphenidate abuse in Texas, 1998-2004.
    Journal of toxicology and environmental health. Part A, 2006, Volume: 69, Issue:12

    Topics: Adolescent; Adolescent Behavior; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity;

2006
Characteristics of methylphenidate dependence syndrome in psychiatric hospital settings.
    Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence, 2006, Volume: 41, Issue:2

    Topics: Adult; Female; Humans; Male; Methamphetamine; Methylphenidate; Substance-Related Disorders

2006
[Diagnosis and treatment of the attention-deficit/hyperactivity syndrome (ADHS) in adults with drug addiction in in-patient and out-patient setting].
    Psychiatrische Praxis, 2006, Volume: 33, Issue:5

    Topics: Adult; Alcoholism; Ambulatory Care; Attention Deficit Disorder with Hyperactivity; Borderline Person

2006
Abuse-resistant drug delivery.
    Pediatric annals, 2006, Volume: 35, Issue:8

    Topics: Administration, Oral; Adolescent; Adult; Central Nervous System Stimulants; Humans; Methylphenidate;

2006
Re: Characteristics of methylphenidate in a university student sample.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2006, Volume: 51, Issue:2

    Topics: Administration, Intranasal; Attention Deficit Disorder with Hyperactivity; Central Nervous System St

2006
Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration.
    Pharmacotherapy, 2006, Volume: 26, Issue:10

    Topics: Adolescent; Adult; Amphetamines; Central Nervous System Stimulants; Drug Prescriptions; Female; Heal

2006
Misuse of methamphetamine and prescription stimulants among youths and young adults in the community.
    Drug and alcohol dependence, 2007, Jul-10, Volume: 89, Issue:2-3

    Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Central Nervous System Stimulants; Com

2007
Sensitization and cross-sensitization after chronic treatment with methylphenidate in adolescent Wistar rats.
    Behavioural pharmacology, 2007, Volume: 18, Issue:3

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Central Nervous System Stimulants; Dose-Respons

2007
From attention-deficit/hyperactivity disorder to medical stimulant use to the diversion of prescribed stimulants to non-medical stimulant use: connecting the dots.
    Addiction (Abingdon, England), 2007, Volume: 102, Issue:5

    Topics: Adolescent; Amphetamines; Attention Deficit Disorder with Hyperactivity; Canada; Central Nervous Sys

2007
Pleasure and discipline in the uses of Ritalin.
    The International journal on drug policy, 2008, Volume: 19, Issue:5

    Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Humans; Methylphen

2008
Patterns and predictors of medication compliance, diversion, and misuse in adult prescribed methylphenidate users.
    Human psychopharmacology, 2007, Volume: 22, Issue:8

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity

2007
Critical assessment of the methylphenidate transdermal system.
    Drugs of today (Barcelona, Spain : 1998), 2007, Volume: 43, Issue:8

    Topics: Adhesiveness; Administration, Cutaneous; Adolescent; Attention Deficit Disorder with Hyperactivity;

2007
The nonmedical use of prescription ADHD medications: results from a national Internet panel.
    Substance abuse treatment, prevention, and policy, 2007, Oct-31, Volume: 2

    Topics: Adolescent; Adult; Alcoholism; Amphetamine-Related Disorders; Appetite Depressants; Attention Defici

2007
Methylphenidate DAT binding in adolescents with Attention-Deficit/ Hyperactivity Disorder comorbid with Substance Use Disorder--a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study.
    NeuroImage, 2008, Apr-15, Volume: 40, Issue:3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Chemistry, Pharmaceutical; Data Interpret

2008
Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood.
    The American journal of psychiatry, 2008, Volume: 165, Issue:5

    Topics: Adolescent; Adult; Age Factors; Attention Deficit Disorder with Hyperactivity; Central Nervous Syste

2008
Four cases of progressive drug abuse.
    The Medical journal of Australia, 1967, Apr-01, Volume: 1, Issue:13

    Topics: Adult; Alcohols; Amphetamine; Barbiturates; Cannabis; Cocaine; Humans; Lysergic Acid Diethylamide; M

1967
Talc retinopathy.
    American journal of ophthalmology, 1980, Volume: 90, Issue:5

    Topics: Adult; Female; Fluorescein Angiography; Humans; Injections, Intravenous; Male; Methylphenidate; Midd

1980
Ocular findings in the intravenous drug abuser.
    Annals of ophthalmology, 1982, Volume: 14, Issue:5

    Topics: Adult; Embolism; Eye Diseases; Female; Heroin; Humans; Injections, Intravenous; Methylphenidate; Neo

1982
An unusual cause of an indolent skin infection.
    Archives of dermatology, 1983, Volume: 119, Issue:7

    Topics: Adult; Bacteroides Infections; Eikenella corrodens; Heroin; Humans; Male; Methylphenidate; Skin Dise

1983
Unacceptable face of private practice: prescription of controlled drugs to addicts.
    British medical journal (Clinical research ed.), 1983, Jun-11, Volume: 286, Issue:6381

    Topics: Cyclizine; Drug and Narcotic Control; Drug Combinations; Drug Prescriptions; Drug Utilization; Femal

1983
Cocaine abuse and its treatment.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:4

    Topics: Antidepressive Agents; Behavior Therapy; Cocaine; Cognition; Conditioning, Psychological; Diazepam;

1984
Methylphenidate (Ritalin) treatment of cocaine dependence--a preliminary report.
    Journal of substance abuse treatment, 1984, Volume: 1, Issue:2

    Topics: Adult; Cocaine; Female; Humans; Male; Methylphenidate; Substance-Related Disorders; Time Factors

1984
Multiple mycotic pulmonary artery aneurysms secondary to intravenous drug abuse.
    AJR. American journal of roentgenology, 1984, Volume: 142, Issue:1

    Topics: Adult; Aneurysm, Infected; Angiography; Endocarditis, Bacterial; Female; Humans; Injections, Intrave

1984
Stimulant medication and the hyperactive adolescent: myths and facts.
    Adolescence, 1983,Winter, Volume: 18, Issue:72

    Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Dextroamphetamine; Dose-Respon

1983
Cautionary note on methylphenidate for cocaine dependence.
    The American journal of psychiatry, 1984, Volume: 141, Issue:2

    Topics: Cocaine; Humans; Legislation, Drug; Methylphenidate; Substance-Related Disorders; United States

1984
Hepatic dysfunction due to intravenous abuse of methylphenidate hydrochloride.
    Journal of clinical gastroenterology, 1984, Volume: 6, Issue:2

    Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Injections, Intravenous; Liver Functi

1984
Hyperactivity and the attention deficit disorders: expanding frontiers.
    Pediatric clinics of North America, 1984, Volume: 31, Issue:2

    Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Behavior Therapy; Child; Cognition; Cogni

1984
Young adult outcome of hyperactive children who received long-term stimulant treatment.
    Journal of the American Academy of Child Psychiatry, 1984, Volume: 23, Issue:3

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Child; Employment; Follow-Up Studies; Humans;

1984
The California registration system for habitues to schedule II drugs.
    NIDA research monograph, 1981, Volume: 34

    Topics: Barbiturates; California; Chronic Disease; Humans; Methylphenidate; Pain; Registries; Substance-Rela

1981
An extreme case of cocaine dependence and marked improvement with methylphenidate treatment.
    The American journal of psychiatry, 1983, Volume: 140, Issue:6

    Topics: Adult; Cocaine; Female; Humans; Methylphenidate; Self Concept; Self Medication; Substance-Related Di

1983
Ritalin: consequences of abuse in a clinical population.
    The International journal of the addictions, 1982, Volume: 17, Issue:2

    Topics: Adult; Female; Humans; Injections, Intravenous; Male; Methadone; Methylphenidate; Opioid-Related Dis

1982
Hemiplegia after intracarotid injection of methylphenidate.
    Archives of neurology, 1982, Volume: 39, Issue:9

    Topics: Adult; Carotid Arteries; Female; Hemiplegia; Humans; Injections, Intra-Arterial; Methylphenidate; Su

1982
Intracranial hemorrhage with amphetamine abuse.
    Neurology, 1981, Volume: 31, Issue:8

    Topics: Adult; Cerebral Hemorrhage; Dextroamphetamine; Humans; Male; Methylphenidate; Substance-Related Diso

1981
Case studies in neuropsychiatry: post-traumatic psychiatric dysfunction--diagnosis and treatment.
    The Journal of clinical psychiatry, 1981, Volume: 42, Issue:3

    Topics: Adult; Brain Injuries; Humans; Male; Methylphenidate; Neurocognitive Disorders; Substance-Related Di

1981
Reversible hemiplegia after presumed intracarotid injection of Ritalin.
    The New England journal of medicine, 1981, May-21, Volume: 304, Issue:21

    Topics: Carotid Arteries; Female; Hemiplegia; Humans; Injections, Intra-Arterial; Methylphenidate; Substance

1981
Retinal detachment and vitreous hemorrhage due to talc emboli.
    JAMA, 1981, Aug-28, Volume: 246, Issue:9

    Topics: Adult; Blindness; Embolism; Hemorrhage; Humans; Injections, Intravenous; Male; Methylphenidate; Reti

1981
67Gallium scanning in talc-induced pulmonary granulomatosis.
    Chest, 1980, Volume: 77, Issue:4

    Topics: Adult; Female; Gallium Radioisotopes; Granuloma; Humans; Hypertension, Pulmonary; Lung Diseases; Met

1980
Medial medullary syndrome in a drug abuser.
    Archives of neurology, 1980, Volume: 37, Issue:7

    Topics: Adult; Brain; Cerebral Infarction; Female; Humans; Injections, Intravenous; Intracranial Embolism an

1980
Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain.
    Archives of general psychiatry, 1995, Volume: 52, Issue:6

    Topics: Adult; Animals; Brain; Carbon Radioisotopes; Cerebellum; Cocaine; Corpus Striatum; Half-Life; Humans

1995
Medication for attention-deficit hyperactivity disorder: balancing art and science.
    Southern medical journal, 1996, Volume: 89, Issue:1

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Agents; Depression

1996
Cognitive event-related potentials in populations at risk for substance abuse.
    NIDA research monograph, 1996, Volume: 159

    Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child;

1996
Neurochemical mechanisms underlying responses to psychostimulants.
    NIDA research monograph, 1996, Volume: 159

    Topics: Animals; Behavior; Brain; Brain Chemistry; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake

1996
Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine.
    Biochemical pharmacology, 1997, Jan-10, Volume: 53, Issue:1

    Topics: Animals; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transpo

1997
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects.
    Nature, 1997, Apr-24, Volume: 386, Issue:6627

    Topics: Adult; Behavior, Addictive; Cocaine; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine Uptak

1997
[Attention deficit hyperactivity disorder, facilitating alcohol and drug abuse in an adult].
    Harefuah, 1997, May-01, Volume: 132, Issue:9

    Topics: Adult; Alcoholism; Attention Deficit Disorder with Hyperactivity; Cannabis; Central Nervous System S

1997
Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates.
    Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42

    Topics: Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane

1998
[Talc pulmonary granulomatosis caused by intravenous administration of methylphenidate].
    Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 1998, Volume: 36, Issue:1

    Topics: Central Nervous System Stimulants; Granuloma, Foreign-Body; Humans; Injections, Intravenous; Lung Di

1998
Intranasal abuse of prescribed methylphenidate.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1998, Volume: 37, Issue:6

    Topics: Administration, Intranasal; Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervo

1998
Stimulant use and the potential for abuse in Wisconsin as reported by school administrators and longitudinally followed children.
    Journal of developmental and behavioral pediatrics : JDBP, 1998, Volume: 19, Issue:3

    Topics: Administrative Personnel; Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Attitude

1998
Intranasal abuse of prescribed methylphenidate.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1998, Volume: 37, Issue:12

    Topics: Administration, Intranasal; Adolescent; Central Nervous System Stimulants; Humans; Male; Methylpheni

1998
Practical guidelines for the treatment of substance abusers with adult attention-deficit hyperactivity disorder.
    Psychiatric services (Washington, D.C.), 1999, Volume: 50, Issue:8

    Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System

1999
Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels.
    The American journal of psychiatry, 1999, Volume: 156, Issue:9

    Topics: Adult; Carbon Radioisotopes; Central Nervous System Stimulants; Corpus Striatum; Dopamine Antagonist

1999
Escalating dose-binge treatment with methylphenidate: role of serotonin in the emergent behavioral profile.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:1

    Topics: Animals; Central Nervous System Stimulants; Dopamine; Male; Methylphenidate; Motor Activity; Rats; R

1999
Central auditory processing disorder and ADHD.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2000, Volume: 39, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Audiometry; Auditory Perceptual Disorders; Central Ne

2000
Diurnal differences in sensitization to methylphenidate.
    Brain research, 2000, May-02, Volume: 864, Issue:1

    Topics: Animals; Brain; Central Nervous System Stimulants; Circadian Rhythm; Dose-Response Relationship, Dru

2000
Student perceptions of methylphenidate abuse at a public liberal arts college.
    Journal of American college health : J of ACH, 2000, Volume: 49, Issue:3

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Attitude to Health; Data Collection; Female; H

2000
Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers.
    The American journal of psychiatry, 2001, Volume: 158, Issue:3

    Topics: Adult; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Caudate Nucleus; Cerebellum;

2001
Near-fatal methylphenidate misuse.
    The British journal of psychiatry : the journal of mental science, 2001, Volume: 178

    Topics: Adolescent; Central Nervous System Stimulants; Female; Humans; Methylphenidate; Respiratory Insuffic

2001
Failed attempts at intranasal abuse of Concerta.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:1

    Topics: Administration, Intranasal; Adolescent; Attention Deficit Disorder with Hyperactivity; Euphoria; Fem

2002
Use of medication by young people with attention-deficit/hyperactivity disorder.
    The Medical journal of Australia, 2002, Jul-01, Volume: 177, Issue:1

    Topics: Adolescent; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Australia; Central

2002
Disk and peripheral retinal neovascularization secondary to talc and cornstarch emboli.
    American journal of ophthalmology, 1979, Volume: 88, Issue:5

    Topics: Adult; Embolism; Excipients; Humans; Injections, Intravenous; Male; Methylphenidate; Neovascularizat

1979
Methylphenidate (Ritalin) abuse.
    The Journal of the Medical Society of New Jersey, 1977, Volume: 74, Issue:12

    Topics: Adult; Granuloma; Humans; Injections, Intravenous; Male; Methylphenidate; Osteomyelitis; Pleural Dis

1977
Talc emboli and macular ischemia in intravenous drug abuse.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1979, Volume: 97, Issue:6

    Topics: Adult; Embolism; Humans; Injections, Intravenous; Ischemia; Macula Lutea; Male; Methylphenidate; Mic

1979
Abuse of prescribed stimulant medication by a 13-year-old hyperactive boy.
    Journal of the American Academy of Child Psychiatry, 1979,Winter, Volume: 18, Issue:1

    Topics: Adolescent; Humans; Hyperkinesis; Male; Methylphenidate; Substance-Related Disorders

1979
Self-injected retinal emboli.
    Ophthalmology, 1979, Volume: 86, Issue:3

    Topics: Adult; Capillaries; Embolism; Female; Fluorescein Angiography; Humans; Injections, Intravenous; Macu

1979
Eosinophilic syndrome with methylphenidate abuse.
    Annals of internal medicine, 1978, Volume: 89, Issue:2

    Topics: Adult; Eosinophilia; Female; Humans; Male; Methylphenidate; Middle Aged; Substance-Related Disorders

1978
Necrotizing fasciitis associated with Haemophilus aphrophilus. Report of a case.
    Archives of internal medicine, 1978, Volume: 138, Issue:11

    Topics: Adult; Anti-Bacterial Agents; Drainage; Fascia; Haemophilus Infections; Humans; Inflammation; Male;

1978
Methylphenidate abuse produces retinopathy.
    JAMA, 1979, Feb-09, Volume: 241, Issue:6

    Topics: Capillaries; Embolism; Humans; Injections, Intravenous; Methylphenidate; Particle Size; Retinal Dise

1979
Behavioral procedures for evaluating the relative abuse potential of CNS drugs in primates.
    Federation proceedings, 1976, Volume: 35, Issue:11

    Topics: Animals; Cocaine; Dose-Response Relationship, Drug; Haplorhini; Humans; Methylphenidate; Papio; Rein

1976
Drug abuse treatment report from Sweden.
    Addictive diseases, 1977, Volume: 3, Issue:1

    Topics: Adult; Amphetamines; Cannabis; Female; Humans; Male; Mental Health Services; Methods; Methylphenidat

1977
Characteristics of unlimited access to self-administered stimulant infusions in dogs.
    Biological psychiatry, 1976, Volume: 11, Issue:5

    Topics: Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Dogs; Humans; Infusions, Parent

1976
Abscess formation as a complication of parenteral methylphenidate abuse.
    JACEP, 1976, Volume: 5, Issue:12

    Topics: Abscess; Adult; Cellulitis; Female; Humans; Injections, Intravenous; Male; Methylphenidate; Skin Dis

1976
Intravenous injection of talc-containing drugs intended for oral use. A cause of pulmonary granulomatosis and pulmonary hypertension.
    The American journal of medicine, 1976, May-10, Volume: 60, Issue:5

    Topics: Adolescent; Adult; Dyspnea; Female; Granuloma; Heroin Dependence; Humans; Hypertension, Pulmonary; I

1976
Methylphenidate (ritalin) abuse and methadone maintenance.
    Diseases of the nervous system, 1975, Volume: 36, Issue:1

    Topics: Adult; Amphetamine; Atropa belladonna; Barbiturates; Diazepam; Female; Heroin Dependence; Humans; Ma

1975
Childhood chemotherapy and later drug abuse and growth curve: a follow-up study of 30 adolescents.
    The American journal of psychiatry, 1975, Volume: 132, Issue:4

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Body Height; Cannabis; Child; Child Behav

1975
Simultaneous detection of a wide variety of commonly abused drugs in a urine screening program using thin-layer identification techniques.
    Journal of chromatography, 1975, Apr-16, Volume: 107, Issue:2

    Topics: 1-Propanol; Ammonia; Ammonium Chloride; Amphetamine; Barbiturates; Chloroform; Chromatography, Thin

1975
[Methylphenidate addiction--Reversal of effect on withdrawal].
    Psychiatria clinica, 1975, Volume: 8, Issue:4

    Topics: Adult; Humans; Hunger; Male; Memory Disorders; Methylphenidate; Sleep Wake Disorders; Substance With

1975
Methylphenidate: a review.
    Southern medical journal, 1976, Volume: 69, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Humans; Hyperkinesis; Methylphenidate; Substance-Rela

1976
Assessment of mazindol for abuse liability.
    NIDA research monograph, 1990, Volume: 105

    Topics: Dose-Response Relationship, Drug; Humans; Male; Mazindol; Methylphenidate; Psychomotor Performance;

1990
Intranasal abuse of prescribed methylphenidate by an alcohol and drug abusing adolescent with ADHD.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1991, Volume: 30, Issue:5

    Topics: Administration, Intranasal; Adolescent; Alcoholism; Arousal; Attention Deficit Disorder with Hyperac

1991
Narcolepsy, paranoid psychosis, and analeptic abuse.
    Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Universite d'Ottawa, 1989, Volume: 14, Issue:3

    Topics: Adult; Dextroamphetamine; Dose-Response Relationship, Drug; Humans; Male; Methylphenidate; Middle Ag

1989
Methylphenidate for cyclosporine-associated organic mood disorder.
    The American journal of psychiatry, 1989, Volume: 146, Issue:4

    Topics: Adult; Cyclosporins; Female; Humans; Methylphenidate; Substance-Related Disorders

1989
Pulmonary talc granulomatosis due to intravenous ritalin.
    Journal of the Tennessee Medical Association, 1988, Volume: 81, Issue:9

    Topics: Adenocarcinoma; Adult; Granuloma; Humans; Injections, Intravenous; Lung Neoplasms; Male; Methylpheni

1988
Pathologic quiz case 1. Intense foreign body with abnormal polarizable material in the soft tissue.
    Archives of otolaryngology--head & neck surgery, 1988, Volume: 114, Issue:7

    Topics: Adult; Foreign-Body Reaction; Granuloma; Humans; Injections, Intravenous; Male; Methylphenidate; Nec

1988
Family abuse of methylphenidate.
    American family physician, 1988, Volume: 38, Issue:2

    Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Family; Female; Humans; Male; Meth

1988
Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse.
    Journal of forensic sciences, 1987, Volume: 32, Issue:3

    Topics: Adult; Dextropropoxyphene; Female; Granuloma; Humans; Liver; Lung; Methylphenidate; Myocardium; Pent

1987
Severe precocious emphysema in intravenous methylphenidate (Ritalin) abusers.
    Chest, 1987, Volume: 92, Issue:6

    Topics: Adult; Emphysema; Female; Humans; Injections, Intravenous; Lung Volume Measurements; Male; Methylphe

1987
Psychosocial aspects of AIDS.
    British journal of hospital medicine, 1987, Volume: 37, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Attitude to Health; Brain Diseases; Child; Dementia; Dextroamphe

1987
Gradual vs. abrupt withdrawal of methylphenidate in two older dependent males.
    Journal of substance abuse treatment, 1985, Volume: 2, Issue:2

    Topics: Aged; Humans; Male; Methylphenidate; Middle Aged; Substance-Related Disorders

1985
Ischaemia following selfadministered intra-arterial injection of methylphenidate and diamorphine. A case report of treatment with intra-arterial urokinase and review.
    Anaesthesia, 1985, Volume: 40, Issue:1

    Topics: Accidents; Adult; Forearm; Heroin; Humans; Injections, Intra-Arterial; Ischemia; Male; Methylphenida

1985
Multiple organ failure resulting from intravenous abuse of methylphenidate hydrochloride.
    Annals of emergency medicine, 1985, Volume: 14, Issue:6

    Topics: Adult; Chemical and Drug Induced Liver Injury; Dopamine; Female; Humans; Injections, Intravenous; Ki

1985
Acute myelopathy in a drug abuser following an attempted neck vein injection.
    Journal of neurology, neurosurgery, and psychiatry, 1985, Volume: 48, Issue:8

    Topics: Adult; Humans; Infusions, Parenteral; Male; Methylphenidate; Pentazocine; Spinal Cord Diseases; Subs

1985
Methylphenidate treatment of cocaine abusers without attention deficit disorder: a negative report.
    The American journal of drug and alcohol abuse, 1985, Volume: 11, Issue:3-4

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cocaine; Humans; Male; Methylphenidate; Substa

1985
Pseudomonas aeruginosa cervical diskitis with chondro-osteomyelitis in an intravenous drug abuser.
    Surgical neurology, 1973, Volume: 1, Issue:3

    Topics: Cervical Vertebrae; Humans; Injections, Intravenous; Intervertebral Disc; Male; Methylphenidate; Mid

1973
[The chemical detection of doping among athletes].
    Deutsche Zeitschrift fur die gesamte gerichtliche Medizin, 1966, Volume: 57, Issue:1

    Topics: Aminobutyrates; Amphetamine; Antidepressive Agents; Caffeine; Central Nervous System Stimulants; Eph

1966
[Catecholamine dependence. Pathogenesis and treatment].
    Cardiologia pratica, 1970, Volume: 21, Issue:1

    Topics: Adrenal Cortex Hormones; Adrenergic beta-Antagonists; Catecholamines; Humans; Metaraminol; Methylphe

1970
The effects of chlorpromazine on psychomotor stimulant self-administration in the rhesus monkey.
    Psychopharmacologia, 1972, Volume: 26, Issue:2

    Topics: Amphetamine; Animals; Behavior, Animal; Chlorpromazine; Cocaine; Drug Antagonism; Humans; Macaca; Me

1972
Symposium: behavior modification by drugs. 3. The clinical use of stimulant drugs in children.
    Pediatrics, 1972, Volume: 49, Issue:5

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Feeding and Eat

1972
Self-inflicted strokes.
    Annals of internal medicine, 1972, Volume: 76, Issue:5

    Topics: Amphetamine; Animals; Cerebral Angiography; Cerebrovascular Disorders; Fundus Oculi; Haplorhini; Hum

1972
Vascular complications of drug abuse.
    Archives of surgery (Chicago, Ill. : 1960), 1972, Volume: 105, Issue:6

    Topics: Adult; Amphetamine; Amputation, Surgical; Aneurysm; Angiography; Arm; Arteries; Barbiturates; Blood

1972
Amphetamine-type drugs for hyperactive children.
    The Medical letter on drugs and therapeutics, 1972, Mar-31, Volume: 14, Issue:7

    Topics: Appetite; Attention Deficit Disorder with Hyperactivity; Body Weight; Brain; Child; Dextroamphetamin

1972
[Significance of amphetamine-like drugs in the psychodynamics of drug abuse in juveniles].
    Deutsche medizinische Wochenschrift (1946), 1973, Feb-16, Volume: 98, Issue:7

    Topics: Adult; Amphetamine; Female; Hallucinations; Humans; Male; Methylphenidate; Psychoses, Substance-Indu

1973
Hyperactive children.
    British medical journal, 1973, Mar-10, Volume: 1, Issue:5853

    Topics: Brain; Child; Dextroamphetamine; Humans; Hyperkinesis; Methylphenidate; Substance-Related Disorders

1973
The continuing problem of barbiturate poisoning.
    American family physician, 1973, Volume: 8, Issue:2

    Topics: Accidents; Acidosis; Barbiturates; Diuresis; Drug Tolerance; Gastric Lavage; Humans; Mannitol; Methy

1973
Methylphenidate.
    Texas medicine, 1973, Volume: 69, Issue:6

    Topics: Humans; Methylphenidate; Substance-Related Disorders

1973
Patterns, range and effects of misused psychotropic substances in Europe.
    The Medical journal of Australia, 1973, Sep-01, Volume: 1, Issue:6

    Topics: Adolescent; Adult; Age Factors; Amphetamine; Analgesics; Cannabis; Drug and Narcotic Control; Europe

1973
Fatal pulmonary hypertension from intravenous injection of methylphenidate (Ritalin) tablets.
    Human pathology, 1972, Volume: 3, Issue:1

    Topics: Adult; Autopsy; Granuloma; Heart Failure; Humans; Hypertension, Pulmonary; Lung; Male; Methylphenida

1972
Psychosis during methylphenidate abuse.
    The New England journal of medicine, 1972, Apr-20, Volume: 286, Issue:16

    Topics: Adult; Female; Humans; Injections, Intravenous; Male; Methylphenidate; Paranoid Disorders; Psychoses

1972
Talc and cornstarch emboli in eyes of drug abusers.
    JAMA, 1972, Volume: 219, Issue:1

    Topics: Adult; Edema; Embolism; Female; Foreign Bodies; Fundus Oculi; Granuloma; Humans; Hypertension, Pulmo

1972
Folie à deux with methylphenidate psychosis.
    The Journal of nervous and mental disease, 1972, Volume: 155, Issue:4

    Topics: Adult; Female; Humans; Interpersonal Relations; Male; Methylphenidate; Paranoid Disorders; Psychoses

1972
[Alcohol and drugs in blood and urine. 100 consecutive cases of persons arrested by the Stockholm police].
    Lakartidningen, 1971, Jun-21, Volume: 68, Issue:30

    Topics: Adolescent; Adult; Alcoholic Intoxication; Amines; Appetite Depressants; Barbiturates; Chromatograph

1971
Methylphenidate problems.
    The New England journal of medicine, 1971, Oct-21, Volume: 285, Issue:17

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Drug and Narcotic Control; Humans; Methylpheni

1971
Drugs: use and abuse.
    The American journal of orthopsychiatry, 1971, Volume: 41, Issue:5

    Topics: Adolescent; Child Psychiatry; Drug Therapy; Humans; Male; Methylphenidate; Substance-Related Disorde

1971
Abuse of anorexics with special reference to newer substances.
    The International journal of the addictions, 1971, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Amines; Amphetamine; Appetite Depressants; Female; Humans; Methamphetamine; Methy

1971
Methylphenidate and the hyperkinetic state.
    Diseases of the nervous system, 1971, Volume: 32, Issue:10

    Topics: Ataxia; Child; Drug Synergism; Feeding and Eating Disorders; Humans; Hyperkinesis; Hypertension; Met

1971
Pulmonary talc granulomatosis. A complication of drug abuse.
    The American review of respiratory disease, 1970, Volume: 101, Issue:1

    Topics: Adult; Granuloma; Hemoptysis; Humans; Injections, Intravenous; Lung Diseases; Male; Methylphenidate;

1970
Let the physician beware.
    Canadian Medical Association journal, 1970, May-30, Volume: 102, Issue:11

    Topics: Depression; Fatigue; Humans; Methylphenidate; Substance-Related Disorders

1970
Speed in Sweden.
    The New England journal of medicine, 1970, Oct-01, Volume: 283, Issue:14

    Topics: Amphetamine; Humans; Methylphenidate; Phenmetrazine; Substance-Related Disorders; Sweden

1970
Intravenous drug abuse. Pulmonary, cardiac, and vascular complications.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1970, Volume: 109, Issue:1

    Topics: Adult; Aneurysm; Aneurysm, Infected; Endocarditis, Bacterial; Female; Heroin; Humans; Hypertension,

1970
Drug interactions with anticoagulants.
    JAMA, 1970, Dec-14, Volume: 214, Issue:11

    Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Anticoagulants; Ascorbic Acid; Barbiturates; Blood Co

1970
Abuse of methylphenidate (Ritalin).
    The New England journal of medicine, 1971, Aug-19, Volume: 285, Issue:8

    Topics: Drug and Narcotic Control; Drug Prescriptions; Humans; Methylphenidate; Substance-Related Disorders;

1971
[Folie à deux associated with methylphenidate addiction].
    Acta psychiatrica Belgica, 1971, Volume: 71, Issue:2

    Topics: Adult; Family Characteristics; Female; Humans; Male; Methylphenidate; Personality Assessment; Psycho

1971
Metastatic endophthalmitis associated with injection of addictive drugs.
    American journal of ophthalmology, 1971, Volume: 71, Issue:5

    Topics: Adult; Amphetamine; Aspergillosis; Cannabis; Eye Diseases; Heroin; Humans; Inflammation; Injections,

1971
[Cerebral stimulants of the amine group in child behavior disorders?].
    Deutsche medizinische Wochenschrift (1946), 1971, Aug-27, Volume: 96, Issue:35

    Topics: Child; Child Behavior Disorders; Humans; Methylphenidate; Phenmetrazine; Substance-Related Disorders

1971
Learning disorders, hyperkinesis, and the use of drugs in children.
    Rehabilitation literature, 1971, Volume: 32, Issue:6

    Topics: Amphetamine; Child; Humans; Hyperkinesis; Learning Disabilities; Methylphenidate; Psychological Test

1971
[Inoculation hepatitis in narcomaniacs and after tattooing].
    Yngre laeger, 1967, Dec-07, Volume: 13, Issue:24

    Topics: Adult; Cannabis; Hepatitis B; Humans; Injections, Intravenous; Male; Methylphenidate; Opium; Phenmet

1967
Drugs for depression.
    British medical journal, 1968, Mar-23, Volume: 1, Issue:5594

    Topics: Amphetamine; Antidepressive Agents; Humans; Methylphenidate; Monoamine Oxidase Inhibitors; Obesity;

1968
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
    British journal of pharmacology, 1968, Volume: 34, Issue:2

    Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine

1968
Methylphenidate (Ritalin).
    The Medical letter on drugs and therapeutics, 1969, May-30, Volume: 11, Issue:11

    Topics: Anorexia Nervosa; Antidepressive Agents; Anxiety; Depression; Humans; Methylphenidate; Sleep Initiat

1969