methylphenidate has been researched along with Autism Spectrum Disorder in 19 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Autism Spectrum Disorder: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We examine the use of parent target problems (PTPs) in a randomized trial of methylphenidate (MPH) in children with autism spectrum disorder and symptoms of attention-deficit/hyperactivity disorder." | 9.24 | Using a Patient-Centered Outcome Measure to Test Methylphenidate Versus Placebo in Children with Autism Spectrum Disorder. ( Aman, MG; Arnold, LE; Bearss, K; Gillespie, S; McCracken, JT; McDougle, CJ; Postorino, V; Sarhangian, R; Scahill, L; Tierney, E; Vitiello, B, 2017) |
| " Although gynecomastia associated with methylphenidate monotherapy in the treatment of attention deficit hyperactivity disorder has already been reported in some adverse event databases, based on a review of the literature it appears that only five case reports have been published." | 9.12 | Possible association between methylphenidate treatment in a child with autism spectrum disorder and subsequent gynecomastia ( Balázs, J; Kollárovics, N; Nagy, P, 2021) |
| "Children with autistic spectrum disorder (ASD) frequently present with inattention, impulsivity and hyperactivity, which are the cardinal symptoms of attention deficit hyperactivity disorder (ADHD)." | 6.55 | Methylphenidate for children and adolescents with autism spectrum disorder. ( Deckx, L; Sturman, N; van Driel, ML, 2017) |
| " We examine the use of parent target problems (PTPs) in a randomized trial of methylphenidate (MPH) in children with autism spectrum disorder and symptoms of attention-deficit/hyperactivity disorder." | 5.24 | Using a Patient-Centered Outcome Measure to Test Methylphenidate Versus Placebo in Children with Autism Spectrum Disorder. ( Aman, MG; Arnold, LE; Bearss, K; Gillespie, S; McCracken, JT; McDougle, CJ; Postorino, V; Sarhangian, R; Scahill, L; Tierney, E; Vitiello, B, 2017) |
| " Although gynecomastia associated with methylphenidate monotherapy in the treatment of attention deficit hyperactivity disorder has already been reported in some adverse event databases, based on a review of the literature it appears that only five case reports have been published." | 5.12 | Possible association between methylphenidate treatment in a child with autism spectrum disorder and subsequent gynecomastia ( Balázs, J; Kollárovics, N; Nagy, P, 2021) |
| "The purpose of this manuscript is to review the evidence generated by clinical trials of pharmaceuticals in autism spectrum disorder (ASD), describe challenges in the conduct of such trials, and discuss future directions RECENT FINDINGS: Clinical trials in ASD have produced several compounds to adequately support the pharmacological treatment of associated symptom domains: attention deficit hyperactivity disorder (methylphenidate, atomoxetine, and alpha agonists), irritability/aggression (risperidone and aripiprazole), sleep (melatonin), and weight gain associated with atypical antipsychotic use (metformin)." | 4.98 | Clinical trials in autism spectrum disorder: evidence, challenges and future directions. ( Anagnostou, E, 2018) |
| " (2020) present a systematic review with meta-analyses that reports the efficacy of five treatments for children with attention-deficit hyperactivity disorder symptoms in the context of autism spectrum disorder - (a) methylphenidate; (b) atomoxetine; (c) guanfacine; (d) aripiprazole; and (e) risperidone." | 4.02 | Commentary: Identifying individualized predictions of response in ADHD pharmacotherapy - a commentary on Rodrigues et al. (2020). ( Bloch, MH; Farhat, LC, 2021) |
| "Methylphenidate was associated with a nonsignificant elevated risk of dropout due to adverse events." | 2.72 | Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis. ( Ameis, SH; Anagnostou, E; Anderson, KK; Beswick, A; Gorman, DA; Lai, MC; Rodrigues, R; Szatmari, P, 2021) |
| "Children with autistic spectrum disorder (ASD) frequently present with inattention, impulsivity and hyperactivity, which are the cardinal symptoms of attention deficit hyperactivity disorder (ADHD)." | 2.55 | Methylphenidate for children and adolescents with autism spectrum disorder. ( Deckx, L; Sturman, N; van Driel, ML, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 11 (57.89) | 2.80 |
| Authors | Studies |
|---|---|
| Kollárovics, N | 1 |
| Nagy, P | 1 |
| Balázs, J | 1 |
| Stevanovic, D | 1 |
| Wentz, E | 1 |
| Nasic, S | 1 |
| Knez, R | 1 |
| Masiran, R | 1 |
| Ilias, MNA | 1 |
| Yubbu, P | 1 |
| Zhou, MS | 1 |
| Nasir, M | 1 |
| Farhat, LC | 2 |
| Kook, M | 1 |
| Artukoglu, BB | 1 |
| Bloch, MH | 2 |
| Rodrigues, R | 1 |
| Lai, MC | 1 |
| Beswick, A | 1 |
| Gorman, DA | 1 |
| Anagnostou, E | 2 |
| Szatmari, P | 1 |
| Anderson, KK | 1 |
| Ameis, SH | 1 |
| Ünsel Bolat, G | 1 |
| Al Awami, R | 1 |
| Albanna, A | 1 |
| Joshi, G | 1 |
| Wilens, T | 1 |
| Firmin, ES | 1 |
| Hoskova, B | 1 |
| Biederman, J | 1 |
| Johansson, V | 1 |
| Sandin, S | 1 |
| Chang, Z | 1 |
| Taylor, MJ | 1 |
| Lichtenstein, P | 1 |
| D'Onofrio, BM | 1 |
| Larsson, H | 1 |
| Hellner, C | 1 |
| Halldner, L | 1 |
| Pham, HTN | 1 |
| Tran, HN | 1 |
| Le, XT | 1 |
| Do, HT | 1 |
| Nguyen, TT | 1 |
| Le Nguyen, C | 1 |
| Yoshida, H | 1 |
| Yamaguchi, M | 1 |
| William, FR | 1 |
| Matsumoto, K | 1 |
| Gunes, S | 1 |
| Kim, SJ | 1 |
| Shonka, S | 1 |
| French, WP | 1 |
| Strickland, J | 1 |
| Miller, L | 1 |
| Stein, MA | 1 |
| Naguy, A | 1 |
| Sturman, N | 1 |
| Deckx, L | 1 |
| van Driel, ML | 1 |
| Howes, OD | 1 |
| Rogdaki, M | 1 |
| Findon, JL | 1 |
| Wichers, RH | 1 |
| Charman, T | 1 |
| King, BH | 1 |
| Loth, E | 1 |
| McAlonan, GM | 1 |
| McCracken, JT | 2 |
| Parr, JR | 1 |
| Povey, C | 1 |
| Santosh, P | 1 |
| Wallace, S | 1 |
| Simonoff, E | 1 |
| Murphy, DG | 1 |
| Giacobini, M | 1 |
| Medin, E | 1 |
| Ahnemark, E | 1 |
| Russo, LJ | 1 |
| Carlqvist, P | 1 |
| Scahill, L | 1 |
| Bearss, K | 1 |
| Sarhangian, R | 1 |
| McDougle, CJ | 1 |
| Arnold, LE | 1 |
| Aman, MG | 1 |
| Tierney, E | 1 |
| Gillespie, S | 1 |
| Postorino, V | 1 |
| Vitiello, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Pharmacologic Management of ADHD in Children and Youth With Autism Spectrum Disorder[NCT05916339] | Phase 4 | 500 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for methylphenidate and Autism Spectrum Disorder
| Article | Year |
|---|---|
Possible association between methylphenidate treatment in a child with autism spectrum disorder and subsequent gynecomastia
Topics: Autism Spectrum Disorder; Child; Gynecomastia; Humans; Male; Methylphenidate | 2021 |
Meta-analysis: Pharmacologic Treatment of Restricted and Repetitive Behaviors in Autism Spectrum Disorders.
Topics: Antipsychotic Agents; Autism Spectrum Disorder; Double-Blind Method; Humans; Methylphenidate; Random | 2021 |
Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis.
Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Autism Spectru | 2021 |
Pharmacotherapy of attention deficit/hyperactivity disorder in individuals with autism spectrum disorder: A systematic review of the literature.
Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; | 2021 |
Methylphenidate for children and adolescents with autism spectrum disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Central Nervous | 2017 |
Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology.
Topics: Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Autism Spectrum D | 2018 |
Clinical trials in autism spectrum disorder: evidence, challenges and future directions.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Aggression; Antipsychotic Agents; Aripipraz | 2018 |
2 trials available for methylphenidate and Autism Spectrum Disorder
| Article | Year |
|---|---|
Dose-Response Effects of Long-Acting Liquid Methylphenidate in Children with Attention Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD): A Pilot Study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Central Nervous | 2017 |
Using a Patient-Centered Outcome Measure to Test Methylphenidate Versus Placebo in Children with Autism Spectrum Disorder.
Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Central Nervous System Stim | 2017 |
10 other studies available for methylphenidate and Autism Spectrum Disorder
| Article | Year |
|---|---|
ASD with ADHD vs. ASD and ADHD alone: a study of the QbTest performance and single-dose methylphenidate responding in children and adolescents.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Central Nervous | 2022 |
Methylphenidate-associated chest pain in a child.
Topics: Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Central Nervous System Stim | 2023 |
Case report: diagnosis and treatment of attention deficit hyperactivity disorder and autism spectrum disorder in patients diagnosed with oculocutaneous albinism.
Topics: Adolescent; Albinism, Oculocutaneous; Attention Deficit Disorder with Hyperactivity; Autism Spectrum | 2020 |
Sedation After a Trial of Mixed Amphetamine Salts in a Boy with Attention-Deficit/Hyperactivity Disorder.
Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Child; Humans; | 2020 |
Medications for attention-deficit/hyperactivity disorder in individuals with or without coexisting autism spectrum disorder: analysis of data from the Swedish prescribed drug register.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Attention Deficit Disorder with Hyperactivity; Autism Sp | 2020 |
Commentary: Identifying individualized predictions of response in ADHD pharmacotherapy - a commentary on Rodrigues et al. (2020).
Topics: Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; | 2021 |
Ilex kudingcha C.J. Tseng Mitigates Phenotypic Characteristics of Human Autism Spectrum Disorders in a Drosophila Melanogaster Rugose Mutant.
Topics: Animals; Autism Spectrum Disorder; Circadian Rhythm; Drosophila melanogaster; Gene Expression; Hippo | 2021 |
Modified-Release Methylphenidate-Related Trichotillomania in a Boy with Autism Spectrum Disorder.
Topics: Autism Spectrum Disorder; Central Nervous System Stimulants; Child; Delayed-Action Preparations; Hum | 2017 |
Pharmacotherapy of Attention Deficit Hyperactivity Disorder Symptom Profile in ASD.
Topics: Aripiprazole; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Autism Spect | 2017 |
Prevalence, Patient Characteristics, and Pharmacological Treatment of Children, Adolescents, and Adults Diagnosed With ADHD in Sweden.
Topics: Adolescent; Adult; Age Distribution; Anxiety Disorders; Attention Deficit Disorder with Hyperactivit | 2018 |