Page last updated: 2024-10-31

methylphenidate and As If Personality

methylphenidate has been researched along with As If Personality in 17 studies

Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.

Research Excerpts

ExcerptRelevanceReference
"Two patients with borderline personality disorder experienced dramatic dysphoric episodes after acute administration of intravenous methylphenidate in a double-blind manner."9.06Dysphoria associated with methylphenidate infusion in borderline personality disorder. ( Cowdry, RW; Gardner, DL; Lucas, PB; Wolkowitz, OM, 1987)
"Two patients with borderline personality disorder experienced dramatic dysphoric episodes after acute administration of intravenous methylphenidate in a double-blind manner."5.06Dysphoria associated with methylphenidate infusion in borderline personality disorder. ( Cowdry, RW; Gardner, DL; Lucas, PB; Wolkowitz, OM, 1987)
"A case is reported of a young woman with attention deficit disorder and concomitant borderline personality disorder who was successfully treated with methylphenidate."3.67Treatment of attention deficit and borderline personality disorders with psychostimulants: case report. ( Hooberman, D; Stern, TA, 1984)
"The Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) measured outcome."2.75OROS methylphenidate in the treatment of adults with ADHD: a 6-month, open-label, follow-up study. ( Halls, C; Marchant, BK; Reimherr, FW; Strong, RE; Williams, ED, 2010)
"Narcolepsy is a commonly under diagnosed or misdiagnosed problem that results in severe daytime sleepiness."2.39Narcolepsy. ( Ware, JC, 1996)
"A subcategory of patients with borderline personality disorder (BPD) who also meet criteria for attention deficit disorder (ADD) has recently been described."1.27Use of imipramine for attention deficit disorder in a borderline patient. ( Denton, C; Satel, S; Southwick, S, 1988)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19906 (35.29)18.7374
1990's2 (11.76)18.2507
2000's0 (0.00)29.6817
2010's8 (47.06)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Rohde, C1
Salagre, E1
Nielsen, J1
Østergaard, SD1
Merrill, RM1
Thygerson, SM1
Palmer, CA1
Gift, TE1
Reimherr, FW6
Marchant, BK6
Steans, TA1
Wender, PH2
Manor, I1
Gutnik, I1
Ben-Dor, DH1
Apter, A1
Sever, J1
Tyano, S1
Weizman, A1
Zalsman, G1
Williams, ED4
Strong, RE4
Halls, C4
Soni, P3
Gale, PD2
Robison, RJ3
Olsen, JL1
Klar, H1
Siever, LJ1
Hooberman, D1
Stern, TA1
Ware, JC1
Sokol, MS1
Gray, NS1
Goldstein, A1
Kaye, WH1
Satel, S1
Southwick, S1
Denton, C1
Robinson, D1
Bailine, S1
Lieberman, J1
Lucas, PB1
Gardner, DL1
Wolkowitz, OM1
Cowdry, RW1
Yoss, RE1
Daly, DD1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Concerta in the Treatment of Adult ADHD and a Comparison of Four Adult ADHD Scales and Effects on Personality[NCT02215538]Phase 2/Phase 347 participants (Actual)Interventional2004-11-30Completed
Methylphenidate Transdermal System (MTS) in the Treatment of Adult ADHD[NCT00506285]Phase 392 participants (Actual)Interventional2007-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Conners' Adult ADHD Rating Scales (CAARS)

Measures the DSM based ADHD criteria of Inattention and Hyperactivity/Impulsivity. There are 30 items scored 0-3 for a minimum score of 0 (no symptoms) and a maximum score of 90 worst possible symptoms. (NCT00506285)
Timeframe: Double-blind endpoints for MTS and placebo arms

Interventionunits on a scale (Mean)
Scores in MTS Arm30.8
Scores in Placebo Arm49.5

Wender Reimherr Adult Attention Deficit Disorder Scale

This scale measures the 7 domains of the Utah Criteria for Adult ADHD. Total scores run from 0 to 28. Normative samples average below 5. The worst possible score is 28. (NCT00506285)
Timeframe: Double-blind endpoints during MTS and placebo arms

Interventionunits on a scale (Mean)
Scores in MTS Arm11.0
Scores in Placebo Arm17.9

Reviews

2 reviews available for methylphenidate and As If Personality

ArticleYear
The psychopharmacologic treatment of personality disorders.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:4

    Topics: Anticonvulsants; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Antisocial Personality Diso

1984
Narcolepsy.
    Virginia medical quarterly : VMQ, 1996,Fall, Volume: 123, Issue:4

    Topics: Amphetamines; Cataplexy; Central Nervous System Stimulants; Diagnosis, Differential; Humans; Methylp

1996

Trials

4 trials available for methylphenidate and As If Personality

ArticleYear
Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.
    The Journal of nervous and mental disease, 2016, Volume: 204, Issue:5

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Diagnostic and Statistical

2016
Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.
    The Journal of nervous and mental disease, 2016, Volume: 204, Issue:5

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Diagnostic and Statistical

2016
Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.
    The Journal of nervous and mental disease, 2016, Volume: 204, Issue:5

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Diagnostic and Statistical

2016
Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.
    The Journal of nervous and mental disease, 2016, Volume: 204, Issue:5

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Diagnostic and Statistical

2016
OROS methylphenidate in the treatment of adults with ADHD: a 6-month, open-label, follow-up study.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2010, Volume: 22, Issue:3

    Topics: Affective Symptoms; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder

2010
Oppositional defiant disorder in adults with ADHD.
    Journal of attention disorders, 2013, Volume: 17, Issue:2

    Topics: Adult; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperact

2013
Dysphoria associated with methylphenidate infusion in borderline personality disorder.
    The American journal of psychiatry, 1987, Volume: 144, Issue:12

    Topics: Adult; Affective Symptoms; Akathisia, Drug-Induced; Borderline Personality Disorder; Double-Blind Me

1987

Other Studies

11 other studies available for methylphenidate and As If Personality

ArticleYear
Use of methylphenidate and the incidence of intentional self-harm or suicide attempts among individuals with schizophrenia, bipolar disorder and personality disorder.
    The Australian and New Zealand journal of psychiatry, 2021, Volume: 55, Issue:4

    Topics: Bipolar Disorder; Humans; Incidence; Methylphenidate; Personality Disorders; Schizophrenia; Self-Inj

2021
Risk of Injury According to Attention Deficit Hyperactivity Disorder, Comorbid Mental Illness, and Medication Therapy.
    Pharmacopsychiatry, 2016, Volume: 49, Issue:2

    Topics: Adolescent; Adult; Amphetamine; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperacti

2016
Possible association between attention deficit hyperactivity disorder and attempted suicide in adolescents - a pilot study.
    European psychiatry : the journal of the Association of European Psychiatrists, 2010, Volume: 25, Issue:3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorb

2010
Personality disorder in ADHD Part 1: Assessment of personality disorder in adult ADHD using data from a clinical trial of OROS methylphenidate.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2010, Volume: 22, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity

2010
Personality disorders in ADHD Part 2: The effect of symptoms of personality disorder on response to treatment with OROS methylphenidate in adults with ADHD.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2010, Volume: 22, Issue:2

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity

2010
Personality disorders in ADHD Part 3: Personality disorder, social adjustment, and their relation to dimensions of adult ADHD.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2010, Volume: 22, Issue:2

    Topics: Adult; Affective Symptoms; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti

2010
Treatment of attention deficit and borderline personality disorders with psychostimulants: case report.
    The Journal of clinical psychiatry, 1984, Volume: 45, Issue:10

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; Delayed-Actio

1984
Methylphenidate treatment for bulimia nervosa associated with a cluster B personality disorder.
    The International journal of eating disorders, 1999, Volume: 25, Issue:2

    Topics: Adult; Bulimia; Central Nervous System Stimulants; Feeding Behavior; Female; Humans; Methylphenidate

1999
Use of imipramine for attention deficit disorder in a borderline patient.
    The Journal of nervous and mental disease, 1988, Volume: 176, Issue:5

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; Humans; Imipr

1988
Dysphoria associated with methylphenidate infusions.
    The American journal of psychiatry, 1988, Volume: 145, Issue:10

    Topics: Adult; Affective Symptoms; Arrhythmias, Cardiac; Borderline Personality Disorder; Humans; Methylphen

1988
On the treatment of narcolepsy.
    The Medical clinics of North America, 1968, Volume: 52, Issue:4

    Topics: Dextroamphetamine; Feeding and Eating Disorders; Humans; Methamphetamine; Methylphenidate; Narcoleps

1968