methylphenidate has been researched along with As If Personality in 17 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients with borderline personality disorder experienced dramatic dysphoric episodes after acute administration of intravenous methylphenidate in a double-blind manner." | 9.06 | Dysphoria associated with methylphenidate infusion in borderline personality disorder. ( Cowdry, RW; Gardner, DL; Lucas, PB; Wolkowitz, OM, 1987) |
| "Two patients with borderline personality disorder experienced dramatic dysphoric episodes after acute administration of intravenous methylphenidate in a double-blind manner." | 5.06 | Dysphoria associated with methylphenidate infusion in borderline personality disorder. ( Cowdry, RW; Gardner, DL; Lucas, PB; Wolkowitz, OM, 1987) |
| "A case is reported of a young woman with attention deficit disorder and concomitant borderline personality disorder who was successfully treated with methylphenidate." | 3.67 | Treatment of attention deficit and borderline personality disorders with psychostimulants: case report. ( Hooberman, D; Stern, TA, 1984) |
| "The Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) measured outcome." | 2.75 | OROS methylphenidate in the treatment of adults with ADHD: a 6-month, open-label, follow-up study. ( Halls, C; Marchant, BK; Reimherr, FW; Strong, RE; Williams, ED, 2010) |
| "Narcolepsy is a commonly under diagnosed or misdiagnosed problem that results in severe daytime sleepiness." | 2.39 | Narcolepsy. ( Ware, JC, 1996) |
| "A subcategory of patients with borderline personality disorder (BPD) who also meet criteria for attention deficit disorder (ADD) has recently been described." | 1.27 | Use of imipramine for attention deficit disorder in a borderline patient. ( Denton, C; Satel, S; Southwick, S, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Rohde, C | 1 |
| Salagre, E | 1 |
| Nielsen, J | 1 |
| Østergaard, SD | 1 |
| Merrill, RM | 1 |
| Thygerson, SM | 1 |
| Palmer, CA | 1 |
| Gift, TE | 1 |
| Reimherr, FW | 6 |
| Marchant, BK | 6 |
| Steans, TA | 1 |
| Wender, PH | 2 |
| Manor, I | 1 |
| Gutnik, I | 1 |
| Ben-Dor, DH | 1 |
| Apter, A | 1 |
| Sever, J | 1 |
| Tyano, S | 1 |
| Weizman, A | 1 |
| Zalsman, G | 1 |
| Williams, ED | 4 |
| Strong, RE | 4 |
| Halls, C | 4 |
| Soni, P | 3 |
| Gale, PD | 2 |
| Robison, RJ | 3 |
| Olsen, JL | 1 |
| Klar, H | 1 |
| Siever, LJ | 1 |
| Hooberman, D | 1 |
| Stern, TA | 1 |
| Ware, JC | 1 |
| Sokol, MS | 1 |
| Gray, NS | 1 |
| Goldstein, A | 1 |
| Kaye, WH | 1 |
| Satel, S | 1 |
| Southwick, S | 1 |
| Denton, C | 1 |
| Robinson, D | 1 |
| Bailine, S | 1 |
| Lieberman, J | 1 |
| Lucas, PB | 1 |
| Gardner, DL | 1 |
| Wolkowitz, OM | 1 |
| Cowdry, RW | 1 |
| Yoss, RE | 1 |
| Daly, DD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Concerta in the Treatment of Adult ADHD and a Comparison of Four Adult ADHD Scales and Effects on Personality[NCT02215538] | Phase 2/Phase 3 | 47 participants (Actual) | Interventional | 2004-11-30 | Completed | ||
| Methylphenidate Transdermal System (MTS) in the Treatment of Adult ADHD[NCT00506285] | Phase 3 | 92 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Measures the DSM based ADHD criteria of Inattention and Hyperactivity/Impulsivity. There are 30 items scored 0-3 for a minimum score of 0 (no symptoms) and a maximum score of 90 worst possible symptoms. (NCT00506285)
Timeframe: Double-blind endpoints for MTS and placebo arms
| Intervention | units on a scale (Mean) |
|---|---|
| Scores in MTS Arm | 30.8 |
| Scores in Placebo Arm | 49.5 |
This scale measures the 7 domains of the Utah Criteria for Adult ADHD. Total scores run from 0 to 28. Normative samples average below 5. The worst possible score is 28. (NCT00506285)
Timeframe: Double-blind endpoints during MTS and placebo arms
| Intervention | units on a scale (Mean) |
|---|---|
| Scores in MTS Arm | 11.0 |
| Scores in Placebo Arm | 17.9 |
2 reviews available for methylphenidate and As If Personality
| Article | Year |
|---|---|
The psychopharmacologic treatment of personality disorders.
Topics: Anticonvulsants; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Antisocial Personality Diso | 1984 |
Narcolepsy.
Topics: Amphetamines; Cataplexy; Central Nervous System Stimulants; Diagnosis, Differential; Humans; Methylp | 1996 |
4 trials available for methylphenidate and As If Personality
| Article | Year |
|---|---|
Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Diagnostic and Statistical | 2016 |
Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Diagnostic and Statistical | 2016 |
Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Diagnostic and Statistical | 2016 |
Personality Disorder in Adult Attention-Deficit/Hyperactivity Disorder: Attrition and Change During Long-term Treatment.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Cross-Over Studies; Diagnostic and Statistical | 2016 |
OROS methylphenidate in the treatment of adults with ADHD: a 6-month, open-label, follow-up study.
Topics: Affective Symptoms; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder | 2010 |
Oppositional defiant disorder in adults with ADHD.
Topics: Adult; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperact | 2013 |
Dysphoria associated with methylphenidate infusion in borderline personality disorder.
Topics: Adult; Affective Symptoms; Akathisia, Drug-Induced; Borderline Personality Disorder; Double-Blind Me | 1987 |
11 other studies available for methylphenidate and As If Personality
| Article | Year |
|---|---|
Use of methylphenidate and the incidence of intentional self-harm or suicide attempts among individuals with schizophrenia, bipolar disorder and personality disorder.
Topics: Bipolar Disorder; Humans; Incidence; Methylphenidate; Personality Disorders; Schizophrenia; Self-Inj | 2021 |
Risk of Injury According to Attention Deficit Hyperactivity Disorder, Comorbid Mental Illness, and Medication Therapy.
Topics: Adolescent; Adult; Amphetamine; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperacti | 2016 |
Possible association between attention deficit hyperactivity disorder and attempted suicide in adolescents - a pilot study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorb | 2010 |
Personality disorder in ADHD Part 1: Assessment of personality disorder in adult ADHD using data from a clinical trial of OROS methylphenidate.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity | 2010 |
Personality disorders in ADHD Part 2: The effect of symptoms of personality disorder on response to treatment with OROS methylphenidate in adults with ADHD.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Comorbidity | 2010 |
Personality disorders in ADHD Part 3: Personality disorder, social adjustment, and their relation to dimensions of adult ADHD.
Topics: Adult; Affective Symptoms; Attention Deficit Disorder with Hyperactivity; Central Nervous System Sti | 2010 |
Treatment of attention deficit and borderline personality disorders with psychostimulants: case report.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; Delayed-Actio | 1984 |
Methylphenidate treatment for bulimia nervosa associated with a cluster B personality disorder.
Topics: Adult; Bulimia; Central Nervous System Stimulants; Feeding Behavior; Female; Humans; Methylphenidate | 1999 |
Use of imipramine for attention deficit disorder in a borderline patient.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Borderline Personality Disorder; Humans; Imipr | 1988 |
Dysphoria associated with methylphenidate infusions.
Topics: Adult; Affective Symptoms; Arrhythmias, Cardiac; Borderline Personality Disorder; Humans; Methylphen | 1988 |
On the treatment of narcolepsy.
Topics: Dextroamphetamine; Feeding and Eating Disorders; Humans; Methamphetamine; Methylphenidate; Narcoleps | 1968 |