methylphenidate has been researched along with Aging in 89 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesized that a single dose of methylphenidate (MP) would modulate cerebral motor activation and behavior in patients having suffered a subcortical stroke." | 9.12 | Methylphenidate modulates cerebral post-stroke reorganization. ( Albucher, JF; Chollet, F; Cognard, C; Conchou, F; Dechaumont-Palacin, S; Franceries, X; Gerdelat, A; Guiraud, V; Leger, A; Loubinoux, I; Marque, P; Pariente, J; Rascol, O; Tardy, J, 2006) |
| "We hypothesized that a single dose of methylphenidate (MP) would modulate cerebral motor activation and behavior in patients having suffered a subcortical stroke." | 5.12 | Methylphenidate modulates cerebral post-stroke reorganization. ( Albucher, JF; Chollet, F; Cognard, C; Conchou, F; Dechaumont-Palacin, S; Franceries, X; Gerdelat, A; Guiraud, V; Leger, A; Loubinoux, I; Marque, P; Pariente, J; Rascol, O; Tardy, J, 2006) |
| "Many of the neurochemical changes associated with aging brain, particularly lower choline acetyltransferase and higher monoamine oxidase, occur with greater severity in senile dementia, Alzheimer's type (SDAT)." | 4.76 | Chemotherapy of cognitive disorders in geriatric subjects. ( Gershon, S; Goodnick, P, 1984) |
| " Patients receiving methylphenidate in a dosage of 20 mg daily improved significantly over a period of six weeks as measured by results of tests for mental status, ward behavior (nursis' rating), target-symptom response, and physician's and nurses' global evaluations." | 2.64 | Withdrawn, apathetic geriatric patients responsive to methylphenidate. ( Kaplitz, SE, 1975) |
| " To evaluate whether the dose-response relationship follows an inverted-U-shaped curve, MPH effects on cognition are also quantified for low, medium and high doses, respectively." | 2.50 | Cognitive effects of methylphenidate in healthy volunteers: a review of single dose studies. ( Linssen, AM; Riedel, WJ; Sambeth, A; Vuurman, EF, 2014) |
| " This dose-response pattern is commonly observed with psychostimulant cognitive modulation." | 1.46 | Methylphenidate has nonlinear dose effects on cued response inhibition in adults but not adolescents. ( Moghaddam, B; Simon, NW, 2017) |
| "Methylphenidate (MPH) is a widely prescribed stimulant drug for the treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents." | 1.42 | Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis. ( Bouet, V; Boulouard, M; Dauphin, F; Dijkhuizen, RM; Freret, T; Homberg, JR; Klomp, A; Lucassen, PJ; Meerhoff, GF; Reneman, L; van der Marel, K, 2015) |
| "When methylphenidate was administered after propofol, the mean time to emergence decreased to 6." | 1.42 | Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. ( Brown, EN; Chemali, JJ; Kenny, JD; Kimchi, EY; Olutola, O; Purdon, PL; Solt, K; Taylor, NE, 2015) |
| "Methylphenidate is a widely prescribed psychostimulant for treatment of attention deficit hyperactivity disorder (ADHD) in children and adolescents, which raises questions regarding its potential interference with the developing brain." | 1.40 | Long-term oral methylphenidate treatment in adolescent and adult rats: differential effects on brain morphology and function. ( Dijkhuizen, RM; Homberg, JR; Klomp, A; Lucassen, PJ; Meerhoff, GF; Reneman, L; Schipper, P; van der Marel, K, 2014) |
| "Methylphenidate (MPH) is a very effective treatment option for children and adolescents with attention-deficit/hyperactivity disorder." | 1.36 | Diurnal differences in memory and learning in young and adult rats treated with methylphenidate. ( Comim, CM; Gomes, KM; Inácio, CG; Martins, MR; Quevedo, J; Réus, GZ; Souza, RP; Valvassori, SS, 2010) |
| "Methylphenidate has been used as an effective treatment for attention deficit hyperactivity disorder (ADHD)." | 1.35 | Methylphenidate alters NCS-1 expression in rat brain. ( Barichello, T; Gomes, KM; Gomez, MV; Quevedo, J; Réus, GZ; Romano-Silva, MA; Rosa, DV; Soares, EC; Souza, BR; Souza, RP, 2008) |
| "Attention deficit hyperactivity disorder is associated with reduced cortical blood flow that is reversible with exposure to the psychostimulant methylphenidate (MPH)." | 1.35 | Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors. ( Andersen, SL; Brenhouse, HC; Napierata, L; Sonntag, KC, 2008) |
| "Methylphenidate is a psychostimulant that acts blocking the dopamine transporter has been used as an effective treatment for Attention Deficit Hyperactivity Disorder." | 1.35 | Cerebral DARPP-32 expression after methylphenidate administration in young and adult rats. ( Gomes, KM; Gomez, MV; Inácio, CG; Martins, MR; Quevedo, J; Réus, GZ; Romano-Silva, MA; Rosa, DV; Soares, EC; Souza, BR; Souza, RP; Valvassori, SS, 2009) |
| "Methylphenidate treatment however did not cause any differences in the number of labelled cells in any group." | 1.35 | Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils. ( Bagorda, F; Brummelte, S; Schaefers, AT; Teuchert-Noodt, G, 2009) |
| "Methylphenidate is a central nervous system stimulant used for the treatment of attention-deficit hyperactivity disorder." | 1.35 | Methylphenidate treatment increases Na(+), K (+)-ATPase activity in the cerebrum of young and adult rats. ( Comim, CM; Ferreira, AG; Gomes, KM; Matté, C; Mattos, C; Quevedo, J; Scherer, EB; Streck, EL; Wyse, AT, 2009) |
| "Methylphenidate (MPH) is a psychostimulant drug used to treat attention deficit hyperactivity disorder in children." | 1.34 | Methylphenidate regulates activity regulated cytoskeletal associated but not brain-derived neurotrophic factor gene expression in the developing rat striatum. ( Carrey, N; Chase, T; Soo, E; Wilkinson, M, 2007) |
| " Thus, our findings have implications for the long-term use of MPH in ADHD." | 1.33 | Methylphenidate differentially regulates c-fos and fosB expression in the developing rat striatum. ( Brown, RE; Carrey, N; Chase, TD; Wilkinson, M, 2005) |
| " An automated, computerized, open-field activity monitoring system was used to study the dose-response characteristics of acute and repeated MPD administration throughout the 11-day experimental protocol." | 1.33 | Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains. ( Dafny, N; Swann, AC; Yang, PB, 2006) |
| "Consequence of the long-term use of psychostimulants as treatment for attention deficit/hyperactivity disorder (ADHD) is unknown, particularly whether treatment with psychostimulants at an early age increases an individual's potential for cross-sensitization to other stimulants exposed at a later age." | 1.32 | Chronic pretreatment with methylphenidate induces cross-sensitization with amphetamine. ( Dafny, N; Swann, AC; Yang, PB, 2003) |
| "Methylphenidate (MPH) is a stimulant prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD)." | 1.32 | Enduring behavioral effects of early exposure to methylphenidate in rats. ( Andersen, SL; Carlezon, WA; Mague, SD, 2003) |
| "Methylphenidate was used significantly more in the aged group, and modafinil in the younger group." | 1.31 | Comparison in symptoms between aged and younger patients with narcolepsy. ( Furuta, H; Temple, HM; Thorpy, MJ, 2001) |
| "To evaluate attention deficit in Alzheimer's disease (AD) and its relationship to attention deficits associated with aging and with medications altering alertness." | 1.29 | Attention deficit in Alzheimer's disease is not simulated by an anticholinergic/antihistaminergic drug and is distinct from deficits in healthy aging. ( Howieson, DB; Kaye, JA; Kishiyama, SS; Oken, BS, 1994) |
| "Triazolam was effective in treating the phase delay that reappeared after chronotherapy." | 1.28 | Daily activity and persistent sleep-wake schedule disorders. ( Iwata, T; Kayukawa, Y; Ohta, T; Okada, T, 1992) |
| "Muscimol pretreatment (dosages ranging from 0." | 1.27 | Ontogeny of GABA-ergic and dopaminergic mediation of gnawing behavior in the mouse. ( Tirelli, E, 1987) |
| "The dose-response relationships for three stimulants have been explored." | 1.25 | The effects of age and illumination on the dose-response curves for three stimulants. ( Isaac, W; Kallman, WM, 1975) |
| "Methylphenidate was administered s." | 1.25 | Methylphenidate effects on avoidance learning at two ages in the rat. ( Gauron, EF; Rowley, VN, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (22.47) | 18.7374 |
| 1990's | 6 (6.74) | 18.2507 |
| 2000's | 33 (37.08) | 29.6817 |
| 2010's | 29 (32.58) | 24.3611 |
| 2020's | 1 (1.12) | 2.80 |
| Authors | Studies |
|---|---|
| Weibel, S | 1 |
| Menard, O | 1 |
| Ionita, A | 1 |
| Boumendjel, M | 1 |
| Cabelguen, C | 1 |
| Kraemer, C | 1 |
| Micoulaud-Franchi, JA | 1 |
| Bioulac, S | 1 |
| Perroud, N | 1 |
| Sauvaget, A | 1 |
| Carton, L | 1 |
| Gachet, M | 1 |
| Lopez, R | 1 |
| Ter Keurst, A | 1 |
| Tuerlings, JHAM | 1 |
| Bertholet, EA | 1 |
| Wijnen, HW | 1 |
| Grazioli, S | 1 |
| Mauri, M | 1 |
| Crippa, A | 1 |
| Maggioni, E | 1 |
| Molteni, M | 1 |
| Brambilla, P | 1 |
| Nobile, M | 1 |
| Réus, GZ | 7 |
| Scaini, G | 3 |
| Furlanetto, CB | 2 |
| Morais, MO | 1 |
| Jeremias, IC | 1 |
| Mello-Santos, LM | 1 |
| Freitas, KV | 1 |
| Quevedo, J | 9 |
| Streck, EL | 4 |
| Daniali, S | 1 |
| Madjd, Z | 1 |
| Shahbazi, A | 1 |
| Niknazar, S | 1 |
| Shahbazzadeh, D | 1 |
| Gill, KE | 1 |
| Beveridge, TJ | 1 |
| Smith, HR | 1 |
| Porrino, LJ | 1 |
| van der Marel, K | 2 |
| Klomp, A | 2 |
| Meerhoff, GF | 2 |
| Schipper, P | 1 |
| Lucassen, PJ | 2 |
| Homberg, JR | 2 |
| Dijkhuizen, RM | 2 |
| Reneman, L | 2 |
| Linssen, AM | 1 |
| Sambeth, A | 1 |
| Vuurman, EF | 1 |
| Riedel, WJ | 1 |
| Steiner, H | 1 |
| Warren, BL | 1 |
| Van Waes, V | 1 |
| Bolaños-Guzmán, CA | 1 |
| Shanks, RA | 1 |
| Ross, JM | 1 |
| Doyle, HH | 1 |
| Helton, AK | 1 |
| Picou, BN | 1 |
| Schulz, J | 1 |
| Tavares, C | 1 |
| Bryant, S | 1 |
| Dawson, BL | 1 |
| Lloyd, SA | 1 |
| Bouet, V | 1 |
| Freret, T | 1 |
| Boulouard, M | 1 |
| Dauphin, F | 1 |
| Chemali, JJ | 1 |
| Kenny, JD | 1 |
| Olutola, O | 1 |
| Taylor, NE | 1 |
| Kimchi, EY | 1 |
| Purdon, PL | 1 |
| Brown, EN | 1 |
| Solt, K | 1 |
| Titus, SE | 1 |
| Wessler, LB | 1 |
| Ferreira, GK | 1 |
| Gonçalves, CL | 1 |
| Jeremias, GC | 1 |
| Somkuwar, SS | 1 |
| Kantak, KM | 1 |
| Bardo, MT | 2 |
| Dwoskin, LP | 2 |
| Dance, A | 1 |
| Simon, NW | 1 |
| Moghaddam, B | 1 |
| Montagnini, BG | 1 |
| Silveira, KM | 1 |
| Pierone, BC | 1 |
| de Azevedo Camim, N | 1 |
| Anselmo-Franci, JA | 1 |
| de Fátima Paccola Mesquita, S | 1 |
| Kiss, ACI | 1 |
| Gerardin, DCC | 1 |
| Souza, RP | 4 |
| Soares, EC | 2 |
| Rosa, DV | 2 |
| Souza, BR | 2 |
| Barichello, T | 1 |
| Gomes, KM | 7 |
| Gomez, MV | 2 |
| Romano-Silva, MA | 2 |
| Andersen, SL | 5 |
| Napierata, L | 2 |
| Brenhouse, HC | 2 |
| Sonntag, KC | 1 |
| Fagundes, AO | 1 |
| Rezin, GT | 1 |
| Zugno, AI | 1 |
| Valvassori, SS | 4 |
| Inácio, CG | 4 |
| Martins, MR | 3 |
| Izquierdo, I | 1 |
| Bevilaqua, LR | 1 |
| Rossato, JI | 1 |
| Lima, RH | 1 |
| Medina, JH | 1 |
| Cammarota, M | 1 |
| Barron, E | 1 |
| Yang, PB | 5 |
| Swann, AC | 5 |
| Dafny, N | 5 |
| Leo, D | 1 |
| Adriani, W | 1 |
| Cavaliere, C | 1 |
| Cirillo, G | 1 |
| Marco, EM | 1 |
| Romano, E | 1 |
| di Porzio, U | 1 |
| Papa, M | 1 |
| Perrone-Capano, C | 1 |
| Laviola, G | 1 |
| Kussmaul, L | 1 |
| Leussis, M | 1 |
| Zhu, HJ | 1 |
| Appel, DI | 1 |
| Jiang, Y | 1 |
| Markowitz, JS | 1 |
| Schaefers, AT | 1 |
| Teuchert-Noodt, G | 2 |
| Bagorda, F | 1 |
| Brummelte, S | 2 |
| Lee, MJ | 2 |
| Wilcox, VT | 2 |
| Burau, KD | 2 |
| Boeck, CR | 1 |
| Dal-Pizzol, F | 1 |
| Silveira, PP | 1 |
| Portella, AK | 1 |
| Assis, SA | 1 |
| Nieto, FB | 1 |
| Diehl, LA | 1 |
| Crema, LM | 1 |
| Peres, W | 1 |
| Costa, G | 1 |
| Scorza, C | 1 |
| Quillfeldt, JA | 1 |
| Lucion, AB | 1 |
| Dalmaz, C | 1 |
| Scherer, EB | 1 |
| Matté, C | 1 |
| Ferreira, AG | 1 |
| Comim, CM | 3 |
| Mattos, C | 1 |
| Wyse, AT | 1 |
| Troiano, AR | 1 |
| Schulzer, M | 2 |
| de la Fuente-Fernandez, R | 2 |
| Mak, E | 2 |
| McKenzie, J | 2 |
| Sossi, V | 2 |
| McCormick, S | 2 |
| Ruth, TJ | 2 |
| Stoessl, AJ | 2 |
| Ruocco, LA | 1 |
| Carnevale, UA | 1 |
| Treno, C | 1 |
| Sadile, AG | 1 |
| Melisi, D | 1 |
| Arra, C | 1 |
| Ibba, M | 1 |
| Schirru, C | 1 |
| Carboni, E | 1 |
| Chen, YI | 1 |
| Choi, JK | 1 |
| Xu, H | 1 |
| Ren, J | 1 |
| Jenkins, BG | 1 |
| Juárez, J | 1 |
| Vázquez-Cortés, C | 1 |
| Biederman, J | 1 |
| Spencer, TJ | 1 |
| Monuteaux, MC | 1 |
| Faraone, SV | 1 |
| Walker, QD | 1 |
| Morris, SE | 1 |
| Arrant, AE | 1 |
| Nagel, JM | 1 |
| Parylak, S | 1 |
| Zhou, G | 1 |
| Caster, JM | 1 |
| Kuhn, CM | 1 |
| Kuramoto, L | 1 |
| Cragg, J | 1 |
| Ramachandiran, N | 1 |
| Au, WL | 1 |
| Lee, CS | 1 |
| Calne, DB | 1 |
| McDougall, SA | 2 |
| Kozanian, OO | 1 |
| Greenfield, VY | 1 |
| Horn, LR | 1 |
| Gutierrez, A | 1 |
| Mohd-Yusof, A | 1 |
| Castellanos, KA | 1 |
| Avital, A | 1 |
| Dolev, T | 1 |
| Aga-Mizrachi, S | 1 |
| Zubedat, S | 1 |
| Amos-Kroohs, RM | 1 |
| Williams, MT | 1 |
| Vorhees, CV | 1 |
| DUBE, AH | 1 |
| OSGOOD, CK | 1 |
| NOTKIN, H | 1 |
| FARNER, D | 1 |
| Carlezon, WA | 3 |
| Mague, SD | 1 |
| Brandon, CL | 1 |
| Marinelli, M | 1 |
| White, FJ | 1 |
| Fukui, R | 1 |
| Svenningsson, P | 1 |
| Matsuishi, T | 1 |
| Higashi, H | 1 |
| Nairn, AC | 1 |
| Greengard, P | 1 |
| Nishi, A | 1 |
| Kilbourn, MR | 1 |
| Konradi, C | 1 |
| Chase, TD | 1 |
| Carrey, N | 3 |
| Brown, RE | 2 |
| Wilkinson, M | 2 |
| Niculescu, M | 1 |
| Ehrlich, ME | 1 |
| Unterwald, EM | 1 |
| Wooters, TE | 1 |
| Tardy, J | 1 |
| Pariente, J | 1 |
| Leger, A | 1 |
| Dechaumont-Palacin, S | 1 |
| Gerdelat, A | 1 |
| Guiraud, V | 1 |
| Conchou, F | 1 |
| Albucher, JF | 1 |
| Marque, P | 1 |
| Franceries, X | 1 |
| Cognard, C | 1 |
| Rascol, O | 1 |
| Chollet, F | 1 |
| Loubinoux, I | 1 |
| Chase, T | 1 |
| Soo, E | 1 |
| Grund, T | 1 |
| Busche, A | 1 |
| Neddens, J | 1 |
| Moll, GH | 1 |
| Dawirs, RR | 1 |
| Jezierski, G | 1 |
| Zehle, S | 1 |
| Bock, J | 1 |
| Braun, K | 1 |
| Gruss, M | 1 |
| Zhu, N | 1 |
| Weedon, J | 1 |
| Dow-Edwards, DL | 1 |
| Vendruscolo, LF | 1 |
| Izídio, GS | 1 |
| Takahashi, RN | 1 |
| Ramos, A | 1 |
| Goodnick, P | 1 |
| Gershon, S | 1 |
| Callaway, E | 3 |
| Anderson, GM | 1 |
| Shaywitz, BA | 1 |
| Leckman, JF | 1 |
| Hunt, RD | 1 |
| Shaywitz, SE | 1 |
| Cohen, DJ | 1 |
| Gualtieri, CT | 1 |
| Hicks, RE | 1 |
| Patrick, K | 1 |
| Schroeder, SR | 1 |
| Breese, GR | 1 |
| Greeley, GH | 1 |
| Jahnke, G | 1 |
| Nicholson, GF | 1 |
| Kizer, JS | 1 |
| Dickerson, JW | 1 |
| Pepler, F | 1 |
| Reigle, TG | 1 |
| Isaac, WL | 1 |
| Isaac, W | 2 |
| Oken, BS | 1 |
| Kishiyama, SS | 1 |
| Kaye, JA | 1 |
| Howieson, DB | 1 |
| Volkow, ND | 1 |
| Ding, YS | 1 |
| Fowler, JS | 1 |
| Wang, GJ | 1 |
| Logan, J | 1 |
| Gatley, SJ | 1 |
| Hitzemann, R | 1 |
| Smith, G | 1 |
| Fields, SD | 1 |
| Gur, R | 1 |
| Prendergast, MA | 1 |
| Jackson, WJ | 1 |
| Terry, AV | 1 |
| Kille, NJ | 1 |
| Arneric, SP | 1 |
| Decker, MW | 1 |
| Buccafusco, JJ | 1 |
| Fang, TY | 1 |
| Tan, SE | 1 |
| Collins, RL | 1 |
| Karper, PE | 1 |
| Watson, JB | 1 |
| Crawford, CA | 1 |
| Furuta, H | 1 |
| Thorpy, MJ | 1 |
| Temple, HM | 1 |
| Arvanitogiannis, A | 1 |
| Pliakas, AM | 1 |
| LeBlanc, C | 1 |
| Penner, MR | 1 |
| McFadyen, MP | 1 |
| Pinaud, R | 1 |
| Robertson, HA | 1 |
| Bartus, RT | 1 |
| Eastgate, SM | 1 |
| Wright, JJ | 1 |
| Werry, JS | 1 |
| Glock, D | 1 |
| Gauron, EF | 2 |
| Rowley, VN | 2 |
| Kaplitz, SE | 1 |
| Kallman, WM | 1 |
| Ohta, T | 1 |
| Iwata, T | 1 |
| Kayukawa, Y | 1 |
| Okada, T | 1 |
| Tirelli, E | 1 |
| Halliday, R | 1 |
| Naylor, H | 1 |
| Gratzinger, P | 1 |
| Prael, R | 1 |
| Mackay, MC | 1 |
| Beck, L | 1 |
| Taylor, R | 1 |
| Sainz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparing The Effects Of Cognitive Behavioral Therapy And Motor Learning Technique in Adults With Attention Deficit Hyperactivity Disorder.[NCT06064032] | 36 participants (Anticipated) | Interventional | 2023-10-02 | Not yet recruiting | |||
| Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.[NCT02462317] | Phase 4 | 184 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| Dopaminergic Neuromodulation of Decision Making in Young and Middle-Aged Adults[NCT03512171] | Phase 1 | 65 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| I123 DAT-SCAN and PET-CT FDG to Assess Brain Function of Parkinson Patients With Different Genetic Characteristic[NCT01089283] | 80 participants (Anticipated) | Observational | 2010-03-31 | Not yet recruiting | |||
| [NCT01089270] | 80 participants (Anticipated) | Observational | 2010-03-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for methylphenidate and Aging
| Article | Year |
|---|---|
Practical considerations for the evaluation and management of Attention Deficit Hyperactivity Disorder (ADHD) in adults.
Topics: Adult; Aging; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Huma | 2020 |
[Apathetic geriatric patient benefits from methylphenidate].
Topics: Aged; Aged, 80 and over; Aging; Apathy; Dementia; Depression; Female; Humans; Male; Methylphenidate; | 2017 |
Light up ADHD: II. Neuropharmacological effects measured by near infrared spectroscopy: is there a biomarker?
Topics: Aging; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Biomarkers; Humans; | 2019 |
Cognitive effects of methylphenidate in healthy volunteers: a review of single dose studies.
Topics: Aging; Brain; Central Nervous System Stimulants; Cognition; Dose-Response Relationship, Drug; Health | 2014 |
Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior.
Topics: Aging; Animals; Behavior, Animal; Brain; Child; Disease Models, Animal; Fluoxetine; Humans; Methylph | 2014 |
Pharmacologic neuroimaging of the ontogeny of dopamine receptor function.
Topics: Adolescent; Adult; Aging; Amphetamine; Animals; Brain; Cerebrovascular Circulation; Cocaine; Dopamin | 2010 |
Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules.
Topics: Aging; Animals; Behavior; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Chil | 2004 |
Chemotherapy of cognitive disorders in geriatric subjects.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Co | 1984 |
Presidential address, 1982. The pharmacology of human information processing.
Topics: Adult; Aged; Aging; Barbiturates; Cognition; Evoked Potentials; Humans; Memory; Methylphenidate; Mid | 1983 |
Developmental and pharmacological aspects of attention deficit disorder (ADD).
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Brain Chemistry; Disease Models, Anim | 1983 |
Diet and hyperactivity.
Topics: Adolescent; Aging; Amphetamines; Child; Child Behavior Disorders; Child, Preschool; Diet; Dietary Ca | 1980 |
3 trials available for methylphenidate and Aging
| Article | Year |
|---|---|
Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Central Nervous System Stimulants; Conditioning, | 2008 |
Methylphenidate modulates cerebral post-stroke reorganization.
Topics: Aged; Aging; Attention; Behavior; Brain; Central Nervous System Stimulants; Cross-Over Studies; Doub | 2006 |
Withdrawn, apathetic geriatric patients responsive to methylphenidate.
Topics: Affective Symptoms; Aged; Aging; Clinical Trials as Topic; Female; Geriatric Nursing; Humans; Male; | 1975 |
75 other studies available for methylphenidate and Aging
| Article | Year |
|---|---|
Methylphenidate treatment leads to abnormalities on krebs cycle enzymes in the brain of young and adult rats.
Topics: Age Factors; Aging; Animals; Brain; Citric Acid Cycle; Methylphenidate; Rats; Rats, Wistar | 2013 |
Chronic Ritalin administration during adulthood increases serotonin pool in rat medial frontal cortex.
Topics: Aging; Animals; Frontal Lobe; Male; Methylphenidate; Rats; Rats, Wistar; Serotonin; Serotonin Plasma | 2013 |
The effects of rearing environment and chronic methylphenidate administration on behavior and dopamine receptors in adolescent rats.
Topics: Aging; Animals; Autoradiography; Behavior, Animal; Brain; Central Nervous System Stimulants; Housing | 2013 |
Long-term oral methylphenidate treatment in adolescent and adult rats: differential effects on brain morphology and function.
Topics: Administration, Oral; Aging; Animals; Brain; Central Nervous System Stimulants; Drug Administration | 2014 |
Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Cocaine; Dose-Response Relationship, | 2015 |
Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis.
Topics: Administration, Oral; Aging; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2015 |
Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain.
Topics: Aging; Anesthesia, General; Anesthetics; Animals; Brain; Electroencephalography; Isoflurane; Male; M | 2015 |
Methylphenidate increases glucose uptake in the brain of young and adult rats.
Topics: Aging; Animals; Brain; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Glucose; | 2015 |
Adolescent methylphenidate treatment differentially alters adult impulsivity and hyperactivity in the Spontaneously Hypertensive Rat model of ADHD.
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Di | 2016 |
Smart drugs: A dose of intelligence.
Topics: Aging; Amphetamines; Animals; Benzhydryl Compounds; Biomedical Enhancement; Caffeine; Child; Cogniti | 2016 |
Methylphenidate has nonlinear dose effects on cued response inhibition in adults but not adolescents.
Topics: Aging; Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, Psychological | 2017 |
Reproductive parameters of female Wistar rats treated with methylphenidate during development.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Body Weight; Central Nervous System Stimulan | 2016 |
Methylphenidate alters NCS-1 expression in rat brain.
Topics: Aging; Animals; Blotting, Western; Brain Chemistry; Central Nervous System Stimulants; Cerebellum; D | 2008 |
Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors.
Topics: Age Factors; Aging; Animals; Attention Deficit Disorder with Hyperactivity; Avoidance Learning; Beha | 2008 |
Methylphenidate increases creatine kinase activity in the brain of young and adult rats.
Topics: Aging; Animals; Brain; Central Nervous System Stimulants; Creatine Kinase; Drug Administration Sched | 2008 |
Cerebral DARPP-32 expression after methylphenidate administration in young and adult rats.
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System Stimula | 2009 |
Adolescent and adult male spontaneous hyperactive rats (SHR) respond differently to acute and chronic methylphenidate (Ritalin).
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Brain; Brain Chemis | 2009 |
Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology.
Topics: Aging; Animals; Behavior, Animal; Cell Enlargement; Cells, Cultured; Central Nervous System Stimulan | 2009 |
Juvenile methylphenidate exposure and factors that influence incentive processing.
Topics: Administration, Oral; Aging; Animals; Central Nervous System Stimulants; Conditioning, Operant; Fema | 2009 |
Age- and sex-related expression and activity of carboxylesterase 1 and 2 in mouse and human liver.
Topics: Adolescent; Adult; Aged; Aging; Animals; Antineoplastic Agents, Phytogenic; Blotting, Western; Campt | 2009 |
Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils.
Topics: Administration, Oral; Aging; Animals; Bromodeoxyuridine; Dentate Gyrus; Gerbillinae; Hippocampus; In | 2009 |
Does repetitive Ritalin injection produce long-term effects on SD female adolescent rats?
Topics: Aging; Animals; Central Nervous System Stimulants; Circadian Rhythm; Female; Methylphenidate; Motor | 2009 |
Superoxide production after acute and chronic treatment with methylphenidate in young and adult rats.
Topics: Aging; Analysis of Variance; Animals; Brain; Central Nervous System Stimulants; Cerebellum; Corpus S | 2009 |
Early life experience alters behavioral responses to sweet food and accumbal dopamine metabolism.
Topics: Aging; Animals; Animals, Newborn; Conditioning, Classical; Diet; Dopamine; Dopamine Uptake Inhibitor | 2010 |
Methylphenidate treatment increases Na(+), K (+)-ATPase activity in the cerebrum of young and adult rats.
Topics: Aging; Animals; Central Nervous System Stimulants; Cerebrum; Corpus Striatum; Dose-Response Relation | 2009 |
Chronic methylphenidate-effects over circadian cycle of young and adult rats submitted to open-field and object recognition tests.
Topics: Aging; Animals; Central Nervous System Stimulants; Circadian Rhythm; Learning; Male; Memory, Short-T | 2009 |
Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function.
Topics: Adult; Aged; Aging; Brain; Carbon Radioisotopes; Caudate Nucleus; Dopamine Plasma Membrane Transport | 2010 |
Prepuberal subchronic methylphenidate and atomoxetine induce different long-term effects on adult behaviour and forebrain dopamine, norepinephrine and serotonin in Naples high-excitability rats.
Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Atomoxetine Hydrochloride; Attention; Attention Defici | 2010 |
Diurnal differences in memory and learning in young and adult rats treated with methylphenidate.
Topics: Aging; Animals; Avoidance Learning; Injections, Intraperitoneal; Male; Memory; Memory, Short-Term; M | 2010 |
Corticosterone treatment before puberty sensitizes the effect of oral methylphenidate on locomotor activity in preadolescence and produces differential effects in adulthood.
Topics: Aging; Animals; Central Nervous System Stimulants; Choice Behavior; Corticosterone; Male; Methylphen | 2010 |
A naturalistic 10-year prospective study of height and weight in children with attention-deficit hyperactivity disorder grown up: sex and treatment effects.
Topics: Adolescent; Age Factors; Aging; Attention Deficit Disorder with Hyperactivity; Body Height; Body Wei | 2010 |
Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
Topics: Aging; Amphetamines; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Dopamine Uptake Inhibitor | 2010 |
Repetitive methylphenidate administration modulates the diurnal behavioral activity pattern of adult female SD rats.
Topics: Aging; Animals; Behavior, Animal; Central Nervous System Stimulants; Circadian Rhythm; Female; Methy | 2011 |
Age-specific progression of nigrostriatal dysfunction in Parkinson's disease.
Topics: Adult; Aged; Aging; Carbon Isotopes; Corpus Striatum; Disease Progression; Female; Fluorodeoxyglucos | 2011 |
One-trial behavioral sensitization in preweanling rats: differential effects of cocaine, methamphetamine, methylphenidate, and D-amphetamine.
Topics: Aging; Animals; Animals, Suckling; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Dex | 2011 |
Environmental enrichment preceding early adulthood methylphenidate treatment leads to long term increase of corticosterone and testosterone in the rat.
Topics: Aging; Animals; Behavior, Animal; Corticosterone; Environment; Freezing; Locomotion; Male; Methylphe | 2011 |
Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats.
Topics: Aging; Animals; Animals, Newborn; Central Nervous System Stimulants; Disease Models, Animal; Female; | 2011 |
The effects of an analeptic (ritalin), an ataraxic (reserpine), and a placebo in senile states.
Topics: Aged; Aging; Central Nervous System Stimulants; Disease; Mental Disorders; Methylphenidate; Reserpin | 1957 |
[Studies on the effect of pharmacological agents on animals of different age. IV. The effect of Ritalin and Regitine on young and old rats].
Topics: Aging; Animals; Methylphenidate; Phentolamine; Rats; Sympatholytics | 1961 |
Chronic pretreatment with methylphenidate induces cross-sensitization with amphetamine.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Dose-Response Relationship, Drug; In | 2003 |
Enduring behavioral effects of early exposure to methylphenidate in rats.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Sti | 2003 |
Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons.
Topics: Action Potentials; Aging; Analysis of Variance; Animals; Animals, Newborn; Dopamine; Dopamine Agents | 2003 |
Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice.
Topics: Aging; Animals; Animals, Newborn; Benzazepines; Cocaine; Dopamine; Dopamine Agonists; Dopamine and c | 2003 |
Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain.
Topics: Aging; Animals; Brain; Carbon Radioisotopes; Corpus Striatum; Dopamine Plasma Membrane Transport Pro | 2004 |
Methylphenidate differentially regulates c-fos and fosB expression in the developing rat striatum.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Centra | 2005 |
Age-specific behavioral responses to psychostimulants in mice.
Topics: Aging; Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Male; Met | 2005 |
Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders.
Topics: Age Factors; Aging; Animals; Behavior, Animal; Central Nervous System Stimulants; Dose-Response Rela | 2006 |
Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains.
Topics: Adolescent; Age Factors; Aging; Animals; Behavior, Animal; Central Nervous System; Central Nervous S | 2006 |
Methylphenidate regulates activity regulated cytoskeletal associated but not brain-derived neurotrophic factor gene expression in the developing rat striatum.
Topics: Administration, Oral; Aging; Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Stim | 2007 |
Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils.
Topics: Administration, Oral; Aging; Amygdala; Animals; Attention Deficit Disorder with Hyperactivity; Centr | 2007 |
Early stress and chronic methylphenidate cross-sensitize dopaminergic responses in the adolescent medial prefrontal cortex and nucleus accumbens.
Topics: Aging; Animals; Attention Deficit Disorder with Hyperactivity; Disease Models, Animal; Dopamine; Dop | 2007 |
Oral methylphenidate improves spatial learning and memory in pre- and periadolescent rats.
Topics: Administration, Oral; Age Factors; Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; | 2007 |
Chronic methylphenidate treatment during adolescence increases anxiety-related behaviors and ethanol drinking in adult spontaneously hypertensive rats.
Topics: Age Factors; Aging; Alcohol Drinking; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Cent | 2008 |
Clinical correlates of methylphenidate blood levels.
Topics: Adult; Aging; Blood Pressure; Blood Specimen Collection; Child; Emotions; Female; Growth Hormone; Hu | 1984 |
Human information-processing: some effects of methylphenidate, age, and scopolamine.
Topics: Adult; Aged; Aging; Arousal; Attention; Cognition; Discrimination Learning; Dose-Response Relationsh | 1984 |
Decreased serum 3,5,3'-triiodothyronine and thyroxine levels accompanying acute and chronic ritalin treatment of developing rats.
Topics: Aging; Animals; Male; Methylphenidate; Organ Size; Parathyroid Glands; Rats; Thyroid Gland; Thyroide | 1980 |
Behavioral and neurochemical interactions of dextroamphetamine and methylphenidate in rats.
Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Dextroamphetamine; Dose-Response | 1981 |
Attention deficit in Alzheimer's disease is not simulated by an anticholinergic/antihistaminergic drug and is distinct from deficits in healthy aging.
Topics: Aged; Aging; Alzheimer Disease; Analysis of Variance; Attention; Diphenhydramine; Female; Histamine | 1994 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Dopamine transporters decrease with age.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Carbon Radioisotopes; Carrier Proteins; Dopamine Plasma | 1996 |
Age-related differences in distractibility and response to methylphenidate in monkeys.
Topics: Aging; Animals; Attention; Conditioning, Psychological; Dopamine Agents; Female; Hippocampus; Macaca | 1998 |
The effects of methylphenidate and maturation on exploratory activity in rats.
Topics: Aging; Animals; Behavior, Animal; Central Nervous System Stimulants; Exploratory Behavior; Male; Met | 1998 |
Effects of repeated methylphenidate treatment in the young rat: sensitization of both locomotor activity and stereotyped sniffing.
Topics: Aging; Animals; Decerebrate State; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Fem | 1999 |
Comparison in symptoms between aged and younger patients with narcolepsy.
Topics: Adolescent; Adult; Aged; Aging; Central Nervous System Stimulants; Female; Humans; Male; Methylpheni | 2001 |
Altered responsiveness to cocaine in rats exposed to methylphenidate during development.
Topics: Adaptation, Physiological; Adult; Aging; Animals; Central Nervous System Stimulants; Child; Cocaine; | 2002 |
Age-related distribution of c-fos expression in the striatum of CD-1 mice after acute methylphenidate administration.
Topics: Aging; Animals; Animals, Newborn; Animals, Outbred Strains; Central Nervous System Stimulants; Corpu | 2002 |
Four stimulants of the central nervous system: effects on short-term memory in young versus aged monkeys.
Topics: Aging; Animals; Caffeine; Central Nervous System Stimulants; Female; Haplorhini; Macaca mulatta; Mal | 1979 |
Behavioural effects of methylphenidate in 6-hydroxydopamine-treated neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Desipramine; Hydroxydopamines; Methylphenidate; | 1978 |
Effects of methylphenidate on avoidance learning in the aged rat.
Topics: Aging; Animals; Avoidance Learning; Conditioning, Operant; Female; Male; Methylphenidate; Motor Acti | 1977 |
The effects of age and illumination on the dose-response curves for three stimulants.
Topics: Adaptation, Psychological; Aging; Animals; Arousal; Caffeine; Darkness; Dextroamphetamine; Dose-Resp | 1975 |
Methylphenidate effects on avoidance learning at two ages in the rat.
Topics: Aging; Animals; Avoidance Learning; Body Weight; Female; Injections, Subcutaneous; Male; Methylpheni | 1975 |
Daily activity and persistent sleep-wake schedule disorders.
Topics: Adolescent; Adult; Aging; Amides; Body Temperature; Circadian Rhythm; Female; Humans; Hydroxybutyrat | 1992 |
Ontogeny of GABA-ergic and dopaminergic mediation of gnawing behavior in the mouse.
Topics: Aging; Animals; Dopamine; Female; gamma-Aminobutyric Acid; Male; Methylphenidate; Mice; Muscimol; St | 1987 |
The effects of stimulant drugs on information processing in elderly adults.
Topics: Adult; Aged; Aging; Cognition; Dextroamphetamine; Female; Humans; Intelligence; Male; Methylphenidat | 1986 |
Methylphenidate for adolescents with minimal brain dysfunction.
Topics: Adolescent; Aging; Attention Deficit Disorder with Hyperactivity; Electroencephalography; Evaluation | 1973 |
Hyperkinetic disease of children: diagnosis and therapy.
Topics: Adolescent; Adult; Aging; Brain Damage, Chronic; Child; Chlordiazepoxide; Dextroamphetamine; Humans; | 1966 |