methylphenidate has been researched along with Age-Related Memory Disorders in 18 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Declarative memory deficits are common in untreated adults with attention-deficit hyperactivity disorder (ADHD), but limited evidence exists to support improvement after treatment with methylphenidate." | 2.75 | Methylphenidate significantly improves declarative memory functioning of adults with ADHD. ( Bekker, EM; Buitelaar, JK; Kooij, JJ; Olivier, B; Verbaten, MN; Verster, JC; Volkerts, ER, 2010) |
| "Methylphenidate (MPH) is an effective medication to improve these cognitive difficulties." | 2.74 | Effects of methylphenidate on working memory functioning in children with attention deficit/hyperactivity disorder. ( Bechtel, N; Klarhöfer, M; Kobel, M; Opwis, K; Penner, IK; Scheffler, K; Specht, K; Weber, P, 2009) |
| "Methylphenidate (MPH) is a psychostimulant widely misused to increase wakefulness by drivers and students." | 1.62 | Stimulants cocktail: Methylphenidate plus caffeine impairs memory and cognition and alters mitochondrial and oxidative status. ( Barcellos, LJG; de Alcantara Barcellos, HH; Fortuna, M; Freddo, N; Koakoski, G; Maffi, VC; Mozzato, MT; Pompermaier, A; Rossato-Grando, LG; Soares, SM; Varela, ACC, 2021) |
| "Methylphenidate (MPH) is a dopamine and norepinephrine reuptake inhibitor that is widely used for the treatment of attention-deficit/hyperactivity disorder in children and adults." | 1.40 | Object memory impairment at post-drug Day 15 but not at Day 1 after a regimen of repeated treatment with oral methylphenidate. ( Bigney, EE; Fry, MD; Hooper, C; Taukulis, HK, 2014) |
| "Thus, overnutrition due to fats may be central to childhood psychological perturbations such as anxiety and ADHD." | 1.39 | Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice. ( Chiu, GS; Freund, GG; Gainey, SJ; Kaczmarczyk, MM; Kelley, KW; Kwakwa, KA; Lawson, MA; Machaj, AS; Martin, SA; Meling, DD; Miller, MJ; Newman, AF; Wang, Y; Woods, JA; York, JM, 2013) |
| " Chronic administration did not cause any effect on memory, but decreased adenosine A(1) receptors immunocontent in the frontal cortex." | 1.37 | Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice. ( Ardais, AP; Botton, PH; Costa, MS; Espinosa, J; Matte, VL; Mioranzza, S; Porciúncula, LO; Souza, DO, 2011) |
| " This study compared the cognitive consequences following chronic treatment with two doses (5 and 10 mg/kg) of methylphenidate on recognition and spatial memory in adult male Long-Evans rats using an established oral dosing procedure." | 1.35 | Chronic oral methylphenidate induces post-treatment impairment in recognition and spatial memory in adult rats. ( LeBlanc-Duchin, D; Taukulis, HK, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Freddo, N | 1 |
| Soares, SM | 1 |
| Fortuna, M | 1 |
| Pompermaier, A | 1 |
| Varela, ACC | 1 |
| Maffi, VC | 1 |
| Mozzato, MT | 1 |
| de Alcantara Barcellos, HH | 1 |
| Koakoski, G | 1 |
| Barcellos, LJG | 1 |
| Rossato-Grando, LG | 1 |
| Li, Y | 1 |
| Yin, A | 1 |
| Sun, X | 1 |
| Zhang, M | 1 |
| Zhang, J | 1 |
| Wang, P | 1 |
| Xie, R | 1 |
| Li, W | 1 |
| Fan, Z | 1 |
| Zhu, Y | 1 |
| Wang, H | 1 |
| Dong, H | 1 |
| Wu, S | 1 |
| Xiong, L | 1 |
| Kaczmarczyk, MM | 1 |
| Machaj, AS | 1 |
| Chiu, GS | 1 |
| Lawson, MA | 1 |
| Gainey, SJ | 1 |
| York, JM | 1 |
| Meling, DD | 1 |
| Martin, SA | 1 |
| Kwakwa, KA | 1 |
| Newman, AF | 1 |
| Woods, JA | 1 |
| Kelley, KW | 1 |
| Wang, Y | 1 |
| Miller, MJ | 1 |
| Freund, GG | 1 |
| Taukulis, HK | 2 |
| Bigney, EE | 1 |
| Fry, MD | 1 |
| Hooper, C | 1 |
| Woolley, ML | 1 |
| Waters, KA | 1 |
| Reavill, C | 1 |
| Bull, S | 1 |
| Lacroix, LP | 1 |
| Martyn, AJ | 1 |
| Hutcheson, DM | 1 |
| Valerio, E | 1 |
| Bate, S | 1 |
| Jones, DN | 1 |
| Dawson, LA | 1 |
| Kobel, M | 1 |
| Bechtel, N | 1 |
| Weber, P | 1 |
| Specht, K | 1 |
| Klarhöfer, M | 1 |
| Scheffler, K | 1 |
| Opwis, K | 1 |
| Penner, IK | 1 |
| LeBlanc-Duchin, D | 1 |
| Valdizán, JR | 1 |
| Izaguerri-Gracia, AC | 1 |
| Verster, JC | 1 |
| Bekker, EM | 1 |
| Kooij, JJ | 1 |
| Buitelaar, JK | 1 |
| Verbaten, MN | 1 |
| Volkerts, ER | 1 |
| Olivier, B | 1 |
| Mioranzza, S | 1 |
| Costa, MS | 1 |
| Botton, PH | 1 |
| Ardais, AP | 1 |
| Matte, VL | 1 |
| Espinosa, J | 1 |
| Souza, DO | 1 |
| Porciúncula, LO | 1 |
| Won, H | 1 |
| Mah, W | 1 |
| Kim, E | 2 |
| Kim, JW | 1 |
| Hahm, EK | 1 |
| Kim, MH | 1 |
| Cho, S | 1 |
| Kim, J | 1 |
| Jang, H | 1 |
| Cho, SC | 1 |
| Kim, BN | 1 |
| Shin, MS | 1 |
| Seo, J | 1 |
| Jeong, J | 1 |
| Choi, SY | 1 |
| Kim, D | 1 |
| Kang, C | 1 |
| Amos-Kroohs, RM | 1 |
| Williams, MT | 1 |
| Vorhees, CV | 1 |
| Strand, MT | 1 |
| Hawk, LW | 1 |
| Bubnik, M | 1 |
| Shiels, K | 1 |
| Pelham, WE | 1 |
| Waxmonsky, JG | 1 |
| Hall, SS | 1 |
| Morice, E | 1 |
| Billard, JM | 1 |
| Denis, C | 1 |
| Mathieu, F | 1 |
| Betancur, C | 1 |
| Epelbaum, J | 1 |
| Giros, B | 1 |
| Nosten-Bertrand, M | 1 |
| Bedard, AC | 1 |
| Tannock, R | 1 |
| Mehta, MA | 1 |
| Calloway, P | 1 |
| Sahakian, BJ | 1 |
| Danke, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double Blind, Placebo-Controlled Crossover Study to Determine the Effects of Methylphenidate on Driving Ability in Adult Patients With Attention-Deficit Hyperactivity Disorder[NCT00223561] | Phase 4 | 18 participants | Interventional | 2003-02-28 | Completed | ||
| Candidate Gene Screening for 6-14 Year Old Patients With ADHD (Attention Deficit/ Hyperactivity Disorder)[NCT03018574] | 100 participants (Actual) | Observational | 2016-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for methylphenidate and Age-Related Memory Disorders
| Article | Year |
|---|---|
Effects of methylphenidate on working memory functioning in children with attention deficit/hyperactivity disorder.
Topics: Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2009 |
Methylphenidate significantly improves declarative memory functioning of adults with ADHD.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Cross-Over | 2010 |
Anxiety, methylphenidate response, and working memory in children with ADHD.
Topics: Anxiety Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2008 |
15 other studies available for methylphenidate and Age-Related Memory Disorders
| Article | Year |
|---|---|
Stimulants cocktail: Methylphenidate plus caffeine impairs memory and cognition and alters mitochondrial and oxidative status.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Cognition; Cognitive Dysfunction; Female; Male | 2021 |
Deficiency of tumor suppressor NDRG2 leads to attention deficit and hyperactive behavior.
Topics: Adaptor Proteins, Signal Transducing; Animals; Astrocytes; Attention Deficit Disorder with Hyperacti | 2017 |
Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Anxiety; Blood Glucose; Body Weight; | 2013 |
Object memory impairment at post-drug Day 15 but not at Day 1 after a regimen of repeated treatment with oral methylphenidate.
Topics: Administration, Oral; Animals; Central Nervous System Stimulants; Exploratory Behavior; Male; Memory | 2014 |
Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat.
Topics: Acetamides; Acetylcholine; Amphetamine; Animals; Behavior, Animal; Cognition; Disease Models, Animal | 2008 |
Chronic oral methylphenidate induces post-treatment impairment in recognition and spatial memory in adult rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Cognition Disorders; Exploratory Behavior; Male | 2009 |
[Attention deficit hyperactivity disorder in adults].
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Atomoxetine Hydrochloride; Attention Deficit Disord | 2009 |
Blockade of adenosine A(1) receptors prevents methylphenidate-induced impairment of object recognition task in adult mice.
Topics: Adenosine A1 Receptor Antagonists; Analysis of Variance; Animals; Central Nervous System Stimulants; | 2011 |
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice.
Topics: Adaptor Proteins, Signal Transducing; Amphetamine; Animals; Attention Deficit Disorder with Hyperact | 2011 |
Neonatal methylphenidate does not impair adult spatial learning in the Morris water maze in rats.
Topics: Aging; Animals; Animals, Newborn; Central Nervous System Stimulants; Disease Models, Animal; Female; | 2011 |
Improving working memory in children with attention-deficit/hyperactivity disorder: the separate and combined effects of incentives and stimulant medication.
Topics: Analysis of Variance; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulan | 2012 |
The quest for a smart pill.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Benzhydryl Compounds; Caffeine; Central Nervous System | 2003 |
Parallel loss of hippocampal LTD and cognitive flexibility in a genetic model of hyperdopaminergia.
Topics: Animals; Brain Diseases, Metabolic; Cognition Disorders; Disease Models, Animal; Dopamine; Dopamine | 2007 |
Amelioration of specific working memory deficits by methylphenidate in a case of adult attention deficit/hyperactivity disorder.
Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Huma | 2000 |
[Methylphenidate addiction--Reversal of effect on withdrawal].
Topics: Adult; Humans; Hunger; Male; Memory Disorders; Methylphenidate; Sleep Wake Disorders; Substance With | 1975 |