Page last updated: 2024-10-31

methylphenidate and Affective Psychosis, Bipolar

methylphenidate has been researched along with Affective Psychosis, Bipolar in 63 studies

Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.

Research Excerpts

ExcerptRelevanceReference
"To examine the short-term efficacy of methylphenidate in the treatment of youths with bipolar disorder (BD) and comorbid attention deficit/hyperactivity disorder (ADHD)."9.12Methylphenidate in the treatment of children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder. ( Calabrese, JR; Demeter, CA; Findling, RL; Gracious, BL; Manos, MJ; McNamara, NK; Short, EJ; Stansbrey, RJ; Whipkey, R, 2007)
"The authors sought to determine the risk of treatment-emergent mania associated with methylphenidate, used in monotherapy or with a concomitant mood-stabilizing medication, in patients with bipolar disorder."7.85The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder. ( Almqvist, C; Chang, Z; D'Onofrio, BM; Landén, M; Larsson, H; Lichtenstein, P; Lundholm, C; Magnusson, PK; Rydén, E; Thase, ME; Viktorin, A, 2017)
"Atomoxetine and OROS methylphenidate were successfully used concomitantly in a 10-year-old boy suffering from attention-deficit/hyperactivity disorder (ADHD) with comorbid bipolar disorder and Tourette syndrome (TS)."7.73Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome. ( Benarroch, F; Gross-Tsur, V; Jaworowski, S, 2006)
" We conducted a randomized crossover trial with MPH and placebo (2 weeks each) combined with aripiprazole in children and adolescents (n = 16; 8-17 years old) with JBPD and ADHD who had a significant response in manic symptoms with aripiprazole but still presented clinically significant symptoms of ADHD."6.74Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder: a randomized crossover trial. ( Ketzer, CR; Pheula, GF; Rohde, LA; Tramontina, S; Zeni, CP, 2009)
"Methylphenidate is a stimulant medication that is sometimes used as an antidepressant in bipolar adults and is frequently used in children with comorbid bipolar and attention-deficit disorder."5.33Naturalistic long-term use of methylphenidate in bipolar disorder. ( El-Mallakh, RS; Lydon, E, 2006)
"Gabapentin is an anticonvulsant drug released in the United States in 1993 for use as adjunctive therapy in refractory partial epilepsy."5.31Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder. ( Bailey, K; Hamrin, V, 2001)
"To examine the short-term efficacy of methylphenidate in the treatment of youths with bipolar disorder (BD) and comorbid attention deficit/hyperactivity disorder (ADHD)."5.12Methylphenidate in the treatment of children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder. ( Calabrese, JR; Demeter, CA; Findling, RL; Gracious, BL; Manos, MJ; McNamara, NK; Short, EJ; Stansbrey, RJ; Whipkey, R, 2007)
"The use of traditional psychostimulants (methylphenidate and dexamphetamine) and stimulant-like drugs (modafinil and armodafinil) for the treatment of depression is a growing concern given the lack of research evidence supporting their effectiveness."4.93Stimulants for depression: On the up and up? ( Bassett, D; Boyce, P; Byrow, Y; Hopwood, M; Lyndon, W; Malhi, GS; Mulder, R; Murray, G; Porter, R; Singh, A, 2016)
"Medication with methylphenidate should be avoided in patients with vulnerability to schizophrenia and in drug addiction, but reported cases without these risk factors demonstrate that a careful and regular psychiatric monitoring is essential in all patients treated with methylphenidate."4.86Methylphenidate-induced psychosis in adult attention-deficit/hyperactivity disorder: report of 3 new cases and review of the literature. ( Kis, B; Kraemer, M; Uekermann, J; Wiltfang, J, 2010)
"The authors sought to determine the risk of treatment-emergent mania associated with methylphenidate, used in monotherapy or with a concomitant mood-stabilizing medication, in patients with bipolar disorder."3.85The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder. ( Almqvist, C; Chang, Z; D'Onofrio, BM; Landén, M; Larsson, H; Lichtenstein, P; Lundholm, C; Magnusson, PK; Rydén, E; Thase, ME; Viktorin, A, 2017)
"In this study, we aimed to evaluate the relationship between attention-deficit/hyperactivity disorder (ADHD) during childhood and subsequent diagnoses of bipolar disorder (BD), as well as to determine whether the pharmacotherapy for ADHD (methylphenidate and atomoxetine) influence the risks of developing BD."3.83Attention-deficit hyperactivity disorder, its pharmacotherapy, and the risk of developing bipolar disorder: A nationwide population-based study in Taiwan. ( Lee, SY; Lee, TL; Shyu, YC; Wang, LJ; Yang, CJ; Yang, KC; Yuan, SS, 2016)
"Atomoxetine and OROS methylphenidate were successfully used concomitantly in a 10-year-old boy suffering from attention-deficit/hyperactivity disorder (ADHD) with comorbid bipolar disorder and Tourette syndrome (TS)."3.73Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome. ( Benarroch, F; Gross-Tsur, V; Jaworowski, S, 2006)
"This study used data from a completed longitudinal study to examine the effects of methylphenidate on 6-12-year-old boys presumably at risk for bipolar disorder."3.70Stimulant treatment in young boys with symptoms suggesting childhood mania: a report from a longitudinal study. ( Arthur, C; Carlson, GA; Kramer, JR; Loney, J; Salisbury, H, 2000)
" In view of increasing interest in the therapeutic potential of carbamazepine (CBZ) in bipolar disorder, we examined the effect of CBZ pretreatment on methylphenidate-induced behavioral activation and euphoria."3.67Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment. ( Bow, J; Gershon, S; Lerer, B; Meyendorff, E; Moore, NC, 1985)
" We conducted a randomized crossover trial with MPH and placebo (2 weeks each) combined with aripiprazole in children and adolescents (n = 16; 8-17 years old) with JBPD and ADHD who had a significant response in manic symptoms with aripiprazole but still presented clinically significant symptoms of ADHD."2.74Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder: a randomized crossover trial. ( Ketzer, CR; Pheula, GF; Rohde, LA; Tramontina, S; Zeni, CP, 2009)
"Some evidence indicates that bipolar depression may be more responsive to dopaminergic agents, suggesting that adjunctive stimulant medication may be an effective treatment for bipolar depression as well as for medication-induced sedation."2.71Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation. ( Carlson, PJ; Merlock, MC; Suppes, T, 2004)
"Methylphenidate has been advocated as an effective antidepressant agent in unipolar depression, and depression secondary to medical illness."2.69An open study of methylphenidate in bipolar depression. ( El-Mallakh, RS, 2000)
"Moreover, the use of antidepressants in bipolar depression is controversial due to concerns regarding the risks of inefficacy or switching to mood elevation."2.49Use of adjunctive stimulants in adult bipolar depression. ( Dell'Osso, B; Ketter, TA, 2013)
"Carvone is a monoterpene that is present in spearmint (Mentha spicata) and caraway (Carum carvi) essential oils and has been shown to have anticonvulsant effects, likely through the blockade of voltage-gated sodium channels, and anxiolytic-like effects."1.43Antimanic-like effects of (R)-(-)-carvone and (S)-(+)-carvone in mice. ( Andreatini, R; Barcaro, IM; de Sousa, DP; Nogoceke, FP, 2016)
"The treatment with methylphenidate (10mg/kg, ip) increased locomotion in the open field test."1.43Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test. ( Asth, L; Gavioli, EC; Lobão-Soares, B; Medeiros, IU; Santos, WB; Silva, EF; Soares-Rachetti, VP; Souza, LS, 2016)
"Carbamazepine was used as a positive control."1.39The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels. ( Andreatini, R; Biojone, C; Casarotto, PC; Correia, D; Guimarães, FS; Joca, SL; Martynhak, BJ; Pereira, M; Siba, IP; Tonelli, DA, 2013)
"Methylphenidate is a stimulant medication that is sometimes used as an antidepressant in bipolar adults and is frequently used in children with comorbid bipolar and attention-deficit disorder."1.33Naturalistic long-term use of methylphenidate in bipolar disorder. ( El-Mallakh, RS; Lydon, E, 2006)
"Gabapentin is an anticonvulsant drug released in the United States in 1993 for use as adjunctive therapy in refractory partial epilepsy."1.31Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder. ( Bailey, K; Hamrin, V, 2001)
"Patients with unipolar depression were studied in a drug-free baseline state following short-term administration of methylphenidate and in a euthymic state in long-term follow-up."1.27Positron emission tomographic study of affective disorders: problems and strategies. ( Baxter, L; Gerner, R; Mazziotta, JC; Phelps, ME, 1984)
"Depression is an important cause of behavioral disturbances in children."1.26Childhood depression: an explanation of a behavior disorder of children. ( Brumback, RA; Weinberg, WA, 1977)

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-199018 (28.57)18.7374
1990's1 (1.59)18.2507
2000's18 (28.57)29.6817
2010's22 (34.92)24.3611
2020's4 (6.35)2.80

Authors

AuthorsStudies
Asth, L2
Tiago, PRF1
Costa, LRF1
Holanda, VAD1
Pacifico, S1
Zaveri, NT1
Calo', G1
Ruzza, C1
Gavioli, EC2
Gomes-Pereira, E1
Covelo, V1
Reis, C1
Friedrich, B1
Bridler, R1
Rohde, C1
Salagre, E1
Nielsen, J1
Østergaard, SD1
Ketter, TA2
Dell'Osso, B2
Zhu, S1
Cordner, ZA1
Xiong, J1
Chiu, CT1
Artola, A1
Zuo, Y1
Nelson, AD1
Kim, TY1
Zaika, N1
Woolums, BM1
Hess, EJ1
Wang, X1
Chuang, DM1
Pletnikov, MM1
Jenkins, PM1
Tamashiro, KL1
Ross, CA1
Hegerl, U2
Mergl, R2
Sander, C2
Dietzel, J2
Bitter, I2
Demyttenaere, K2
Gusmão, R2
González-Pinto, A2
Zorrilla, I1
Alocén, AG1
Sola, VP1
Vieta, E2
Juckel, G2
Zimmermann, US2
Bauer, M2
Sienaert, P2
Quintão, S2
Edel, MA2
Bolyos, C2
Ayuso-Mateos, JL2
López-García, P2
Kluge, M2
Tonelli, DA1
Pereira, M1
Siba, IP1
Martynhak, BJ1
Correia, D1
Casarotto, PC1
Biojone, C1
Guimarães, FS1
Joca, SL1
Andreatini, R3
Perez-Sola, V1
Parker, G2
Brotchie, H2
McClure, G1
Fletcher, K1
Rubia, K1
Alegría, AA1
Brinson, H1
Wassef, N1
Khan, N1
Munir, S1
Wang, LJ1
Shyu, YC1
Yuan, SS1
Yang, CJ1
Yang, KC1
Lee, TL1
Lee, SY1
Laurito, LD1
Fontenelle, LF1
Kahn, DA1
Malhi, GS1
Byrow, Y1
Bassett, D1
Boyce, P1
Hopwood, M1
Lyndon, W1
Mulder, R1
Porter, R1
Singh, A1
Murray, G1
Nogoceke, FP1
Barcaro, IM1
de Sousa, DP1
Souza, LS1
Silva, EF1
Santos, WB1
Lobão-Soares, B1
Soares-Rachetti, VP1
Medeiros, IU1
Viktorin, A1
Rydén, E1
Thase, ME1
Chang, Z1
Lundholm, C1
D'Onofrio, BM1
Almqvist, C1
Magnusson, PK1
Lichtenstein, P1
Larsson, H1
Landén, M1
Mattingly, GW1
Anderson, RH1
Kummer, A1
Teixeira, A1
Wagner, KD1
Atmaca, M1
Ozler, S1
Topuz, M1
Goldstein, S1
Zeni, CP1
Tramontina, S1
Ketzer, CR1
Pheula, GF1
Rohde, LA1
McLaren, JL1
Cauble, S1
Barnett, RJ1
Rothermel, B1
Poustka, L1
Banaschewski, T1
Becker, K1
Park, YM1
Jung, YK1
Kraemer, M1
Uekermann, J1
Wiltfang, J1
Kis, B1
Barbosa, FJ1
Hesse, B1
de Almeida, RB1
Baretta, IP1
Boerngen-Lacerda, R1
Kowatch, RA1
Sethuraman, G1
Hume, JH1
Kromelis, M1
Weinberg, WA2
Galanter, CA1
Carlson, GA3
Jensen, PS1
Greenhill, LL1
Davies, M1
Li, W1
Chuang, SZ1
Elliott, GR1
Arnold, LE1
March, JS1
Hechtman, L1
Pelham, WE1
Swanson, JM1
MORGAN, DR1
Carlson, PJ1
Merlock, MC1
Suppes, T1
Benjamin, E1
Salek, S1
Jaworowski, S1
Benarroch, F1
Gross-Tsur, V1
Ross, RG1
Lydon, E1
El-Mallakh, RS2
Sharp, BW1
Tahiroglu, AY1
Avci, A1
Findling, RL1
Short, EJ1
McNamara, NK1
Demeter, CA1
Stansbrey, RJ1
Gracious, BL1
Whipkey, R1
Manos, MJ1
Calabrese, JR1
Janowsky, DS4
Judd, LL1
Huey, LY1
Risch, SC1
Segal, DS1
Phelps, ME1
Mazziotta, JC1
Baxter, L1
Gerner, R1
Bannet, J1
Ebstein, RP2
Belmaker, RH2
Loney, J1
Salisbury, H1
Kramer, JR1
Arthur, C1
Bschor, T1
Müller-Oerlinghausen, B1
Ulrich, G1
Hamrin, V1
Bailey, K1
Davis, JM4
Kadouch, R1
Peres, L1
Leichner, P1
Parker, D1
Judd, L1
Huey, L1
Clopton, P1
Brown, WA1
Mueller, B1
Bloomingdale, LM1
Bressler, B1
Meyers, B1
Brumback, RA1
Gershon, S2
Angrist, B1
Shopsin, B1
Rapport, MD1
Kelly, KL1
Pataki, CS1
Schmidt, K1
Delaney, MA1
Jensen, M1
Levinson, DF1
Lewitt, M1
Koehler-Troy, C1
Strober, M1
Malenbaum, R1
Meyendorff, E1
Lerer, B1
Moore, NC1
Bow, J1
el-Yousel, MK1
Sekerke, HJ2
el-Yousef, MK1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
International Randomised Double-blind Placebo-controlled Study on the Initial Treatment of Acute Mania With Methylphenidate[NCT01541605]Phase 342 participants (Actual)Interventional2012-03-31Completed
Aripiprazole Associated With Methylphenidate in Children and Adolescents With Bipolar Disorder and ADHD: A Randomized Cross-Over Placebo Controlled Trial[NCT00305370]Phase 420 participants (Anticipated)Interventional2005-08-31Completed
Multimodal Treatment Study of Children With ADHD[NCT00000388]Phase 40 participants Interventional1998-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for methylphenidate and Affective Psychosis, Bipolar

ArticleYear
Brain abnormalities in attention-deficit hyperactivity disorder: a review.
    Revista de neurologia, 2014, Feb-24, Volume: 58 Suppl 1

    Topics: Adolescent; Adult; Atomoxetine Hydrochloride; Attention Deficit and Disruptive Behavior Disorders; A

2014
Stimulants for depression: On the up and up?
    The Australian and New Zealand journal of psychiatry, 2016, Volume: 50, Issue:3

    Topics: Amphetamine; Antidepressive Agents; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System S

2016
Optimizing outcomes in ADHD treatment: from clinical targets to novel delivery systems.
    CNS spectrums, 2016, Volume: 21, Issue:S1

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic Uptake Inhibitors; Anxiety Disorders; Atomoxetine H

2016
Methylphenidate-induced psychosis in adult attention-deficit/hyperactivity disorder: report of 3 new cases and review of the literature.
    Clinical neuropharmacology, 2010, Volume: 33, Issue:4

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous System Stimu

2010
Use of adjunctive stimulants in adult bipolar depression.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:1

    Topics: Adult; Antipsychotic Agents; Benzhydryl Compounds; Bipolar Disorder; Central Nervous System Stimulan

2013
Behavioral effects of opioid receptor antagonists in psychopathologic states.
    The Psychiatric clinics of North America, 1983, Volume: 6, Issue:3

    Topics: Affective Disorders, Psychotic; Animals; beta-Endorphin; Bipolar Disorder; Clinical Trials as Topic;

1983

Trials

12 trials available for methylphenidate and Affective Psychosis, Bipolar

ArticleYear
A multi-centre, randomised, double-blind, placebo-controlled clinical trial of methylphenidate in the initial treatment of acute mania (MEMAP study).
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2018, Volume: 28, Issue:1

    Topics: Acute Disease; Adult; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Female; Humans; Male;

2018
Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate.
    BMC psychiatry, 2013, Feb-27, Volume: 13

    Topics: Acute Disease; Adult; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Female; Humans; Male;

2013
Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder: a randomized crossover trial.
    Journal of child and adolescent psychopharmacology, 2009, Volume: 19, Issue:5

    Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Attention Deficit Disorder with Hyperactivity; Bipol

2009
Combination pharmacotherapy in children and adolescents with bipolar disorder.
    Biological psychiatry, 2003, Jun-01, Volume: 53, Issue:11

    Topics: Adolescent; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Attention Deficit Disorde

2003
Adjunctive stimulant use in patients with bipolar disorder: treatment of residual depression and sedation.
    Bipolar disorders, 2004, Volume: 6, Issue:5

    Topics: Adult; Aged; Amphetamine; Antipsychotic Agents; Bipolar Disorder; Central Nervous System Stimulants;

2004
Methylphenidate in the treatment of children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2007, Volume: 46, Issue:11

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous System

2007
Behavioral effects of opioid receptor antagonists in psychopathologic states.
    The Psychiatric clinics of North America, 1983, Volume: 6, Issue:3

    Topics: Affective Disorders, Psychotic; Animals; beta-Endorphin; Bipolar Disorder; Clinical Trials as Topic;

1983
An open study of methylphenidate in bipolar depression.
    Bipolar disorders, 2000, Volume: 2, Issue:1

    Topics: Adult; Amphetamines; Antidepressive Agents; Bipolar Disorder; Drug Therapy, Combination; Female; Fol

2000
The effect of methylphenidate on serum growth hormone: influence of antipsychotic drugs and diagnosis.
    Archives of general psychiatry, 1978, Volume: 35, Issue:11

    Topics: Adjustment Disorders; Adolescent; Adult; Alcoholism; Antipsychotic Agents; Bipolar Disorder; Blood P

1978
Alleviation of manic symptoms with catecholamine agonists.
    The American journal of psychiatry, 1979, Volume: 136, Issue:2

    Topics: Apomorphine; Bipolar Disorder; Clinical Trials as Topic; Dextroamphetamine; Double-Blind Method; Hum

1979
The effects of methylphenidate and lithium on attention and activity level.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:2

    Topics: Arousal; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Drug Therapy, Combi

1992
Provocation of schizophrenic symptoms by intravenous administration of methylphenidate.
    Archives of general psychiatry, 1973, Volume: 28, Issue:2

    Topics: Adolescent; Adult; Bipolar Disorder; Brain Chemistry; Chlorpromazine; Clinical Trials as Topic; Dopa

1973

Other Studies

46 other studies available for methylphenidate and Affective Psychosis, Bipolar

ArticleYear
Effects of non-peptide nociceptin/orphanin FQ receptor ligands on methylphenidate-induced hyperactivity in mice: Implications for bipolar disorders.
    Neuropeptides, 2020, Volume: 82

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Female; Hyperkinesis; Imidazoles; Methylphenidate; Mice

2020
Methylphenidate as a short-term adjunct therapy in bipolar depression - case report.
    Actas espanolas de psiquiatria, 2020, Volume: 48, Issue:3

    Topics: Adult; Antidepressive Agents; Bipolar Disorder; Drug Therapy, Combination; Humans; Male; Methylpheni

2020
    Praxis, 2020, Volume: 109, Issue:16

    Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Humans; Mania; Methylphenidate; Moo

2020
Use of methylphenidate and the incidence of intentional self-harm or suicide attempts among individuals with schizophrenia, bipolar disorder and personality disorder.
    The Australian and New Zealand journal of psychiatry, 2021, Volume: 55, Issue:4

    Topics: Bipolar Disorder; Humans; Incidence; Methylphenidate; Personality Disorders; Schizophrenia; Self-Inj

2021
Commentary on the Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder.
    The American journal of psychiatry, 2017, 08-01, Volume: 174, Issue:8

    Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous System Stimulants;

2017
Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 09-26, Volume: 114, Issue:39

    Topics: Animals; Ankyrins; Bipolar Disorder; Disease Models, Animal; GABAergic Neurons; Lithium; Methylpheni

2017
The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:6

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Carbamazepine; Disease Models, Animal; Dose-Response Re

2013
Psychostimulants for managing unipolar and bipolar treatment-resistant melancholic depression: a medium-term evaluation of cost benefits.
    Journal of affective disorders, 2013, Volume: 151, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Bipolar Disorder; Central Nervous System Stimulants; Cost-Benefit An

2013
Quetiapine-induced myocarditis presenting as acute STEMI.
    BMJ case reports, 2015, Jan-09, Volume: 2015

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; C

2015
Attention-deficit hyperactivity disorder, its pharmacotherapy, and the risk of developing bipolar disorder: A nationwide population-based study in Taiwan.
    Journal of psychiatric research, 2016, Volume: 72

    Topics: Adolescent; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Bipolar Disord

2016
Hoarding Symptoms Respond to Treatment for Rapid Cycling Bipolar II Disorder.
    Journal of psychiatric practice, 2016, Volume: 22, Issue:1

    Topics: Bipolar Disorder; Calcium Channel Blockers; Depressive Disorder; Dopamine Uptake Inhibitors; Hoardin

2016
Antimanic-like effects of (R)-(-)-carvone and (S)-(+)-carvone in mice.
    Neuroscience letters, 2016, Apr-21, Volume: 619

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Cyclohexane Monoterpenes; Male; Methylphenidate; Mice;

2016
Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test.
    Neuroscience letters, 2016, 08-26, Volume: 629

    Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Central Nervous System Stimulants; Di

2016
The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder.
    The American journal of psychiatry, 2017, 04-01, Volume: 174, Issue:4

    Topics: Adolescent; Adult; Antimanic Agents; Bipolar Disorder; Central Nervous System Stimulants; Cohort Stu

2017
Methylphenidate in attention deficit hyperactivity disorder and bipolar disorder.
    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2008, Volume: 16, Issue:6

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous Sy

2008
Recognizing parents' symptoms, obesity, and bipolar depression.
    The Journal of clinical psychiatry, 2008, Volume: 69, Issue:12

    Topics: Adolescent; Age Factors; Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2008
Attention deficit hyperactivity disorder erroneously diagnosed and treated as bipolar disorder.
    Journal of attention disorders, 2009, Volume: 13, Issue:2

    Topics: Adult; Antimanic Agents; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzod

2009
Do the old psychostimulant drugs have a role in managing treatment-resistant depression?
    Acta psychiatrica Scandinavica, 2010, Volume: 121, Issue:4

    Topics: Adult; Antidepressive Agents, Tricyclic; Bipolar Disorder; Central Nervous System Stimulants; Depres

2010
Aripiprazole induced acute dystonia after discontinuation of a stimulant medication.
    Journal of clinical psychopharmacology, 2010, Volume: 30, Issue:1

    Topics: Acute Disease; Antipsychotic Agents; Aripiprazole; Attention Deficit Disorder with Hyperactivity; Bi

2010
[Bipolar disorders as co-morbidity in childhood and adolescence--underdiagnosed or overinterpreted? Therapy of a 14-year-old boy with hyperkinetic conduct disorder and hypomania].
    Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie, 2010, Volume: 38, Issue:2

    Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; A

2010
Manic switch and serotonin syndrome induced by augmentation of paroxetine with methylphenidate in a patient with major depression.
    Progress in neuro-psychopharmacology & biological psychiatry, 2010, May-30, Volume: 34, Issue:4

    Topics: Adolescent; Bipolar Disorder; Depressive Disorder, Major; Drug Therapy, Combination; Humans; Male; M

2010
Magnesium sulfate and sodium valproate block methylphenidate-induced hyperlocomotion, an animal model of mania.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:1

    Topics: Animals; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Central Nervous System Stimulants; Dis

2011
Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the multimodal treatment study of children with attention deficit hyperactivity disorder titration trial.
    Journal of child and adolescent psychopharmacology, 2003,Summer, Volume: 13, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Chi-Square Distribution; Child; Dru

2003
Largactil, ritalin and meratran in the treatment of endogenous psychotic depression.
    The Medical journal of Australia, 1957, Jul-06, Volume: 44, Issue:1

    Topics: Bipolar Disorder; Chlorpromazine; Depression; Depressive Disorder, Major; Methylphenidate; Piperidin

1957
Stimulant-atypical antipsychotic interaction and acute dystonia.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2005, Volume: 44, Issue:6

    Topics: Adolescent; Aggression; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar

2005
Concomitant use of atomoxetine and OROS-methylphenidate in a 10-year-old child suffering from attention-deficit/hyperactivity disorder with comorbid bipolar disorder and Tourette syndrome.
    Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:3

    Topics: Adrenergic Uptake Inhibitors; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivi

2006
Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder.
    The American journal of psychiatry, 2006, Volume: 163, Issue:7

    Topics: Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Ne

2006
Naturalistic long-term use of methylphenidate in bipolar disorder.
    Journal of clinical psychopharmacology, 2006, Volume: 26, Issue:5

    Topics: Adolescent; Adult; Antidepressive Agents; Antipsychotic Agents; Attention; Attention Deficit Disorde

2006
Cmap ADHD and comorbid aggression algorithm.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2007, Volume: 46, Issue:1

    Topics: Aggression; Algorithms; Attention Deficit Disorder with Hyperactivity; Biomedical Research; Bipolar

2007
Polypharmacy and EPS in a child; a case report.
    Psychopharmacology bulletin, 2007, Volume: 40, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Benztropine; Bipolar Disorder; Child; Comorbidity; Do

2007
Positron emission tomographic study of affective disorders: problems and strategies.
    Annals of neurology, 1984, Volume: 15 Suppl

    Topics: Bipolar Disorder; Depressive Disorder; Female; Glucose; Humans; Lithium; Male; Methylphenidate; Mood

1984
Clinical aspects of the interaction of lithium and stimulants.
    The British journal of psychiatry : the journal of mental science, 1980, Volume: 136

    Topics: Bipolar Disorder; Drug Interactions; Humans; Lithium; Male; Methylphenidate; Middle Aged

1980
Stimulant treatment in young boys with symptoms suggesting childhood mania: a report from a longitudinal study.
    Journal of child and adolescent psychopharmacology, 2000,Fall, Volume: 10, Issue:3

    Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous System Stimulants;

2000
Decreased level of EEG-vigilance in acute mania as a possible predictor for a rapid effect of methylphenidate: a case study.
    Clinical EEG (electroencephalography), 2001, Volume: 32, Issue:1

    Topics: Bipolar Disorder; Central Nervous System Stimulants; Electroencephalography; Female; Humans; Male; M

2001
Gabapentin and methylphenidate treatment of a preadolescent with attention deficit hyperactivity disorder and bipolar disorder.
    Journal of child and adolescent psychopharmacology, 2001,Fall, Volume: 11, Issue:3

    Topics: Acetates; Amines; Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder;

2001
Critique of single amine theories: evidence of a cholinergic influence in the major mental illnesses.
    Research publications - Association for Research in Nervous and Mental Disease, 1975, Volume: 54

    Topics: Adolescent; Adult; Age Factors; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bipolar Diso

1975
Thphenidate.
    Neuropsychobiology, 1977, Volume: 3, Issue:4

    Topics: Adjustment Disorders; Adrenergic beta-Agonists; Adult; Bipolar Disorder; Blood Pressure; Cyclic AMP;

1977
Rapid intramuscular administration of tricyclic antidepressants.
    The American journal of psychiatry, 1979, Volume: 136, Issue:8

    Topics: Adjustment Disorders; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depr

1979
Treatment of imipramine-resistant depression and lithium-refractory mania through drug interactions.
    The American journal of psychiatry, 1978, Volume: 135, Issue:11

    Topics: Adult; Bipolar Disorder; Chlorothiazide; Diabetes Insipidus; Drug Interactions; Humans; Imipramine;

1978
Childhood depression: an explanation of a behavior disorder of children.
    Perceptual and motor skills, 1977, Volume: 44, Issue:3 Pt 1

    Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Child; Child Behavior Disorders; Depression; Dex

1977
Drugs, diagnosis, and disease.
    Research publications - Association for Research in Nervous and Mental Disease, 1975, Volume: 54

    Topics: Acetylcholine; Amphetamines; Bipolar Disorder; Humans; Imipramine; Levodopa; Lithium; Methylphenidat

1975
Methylphenidate challenge in a manic boy.
    Biological psychiatry, 1986, Volume: 21, Issue:11

    Topics: Bipolar Disorder; Child; Humans; Male; Methylphenidate

1986
Methylphenidate-induced mania in a prepubertal child.
    The Journal of clinical psychiatry, 1986, Volume: 47, Issue:11

    Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Child Behavior Disorders; Hu

1986
Methylphenidate infusion in euthymic bipolars: effect of carbamazepine pretreatment.
    Psychiatry research, 1985, Volume: 16, Issue:4

    Topics: Adult; Arousal; Bipolar Disorder; Carbamazepine; Euphoria; Female; Humans; Infusions, Parenteral; Ma

1985
A two factor theory of schizophrenia.
    Journal of psychiatric research, 1974, Volume: 11

    Topics: Acetylcholine; Amphetamine; Animals; Bipolar Disorder; Brain; Dextroamphetamine; Dopamine; Dose-Resp

1974
Antagonistic effects of physostigmine and methylphenidate in man.
    The American journal of psychiatry, 1973, Volume: 130, Issue:12

    Topics: Affective Symptoms; Behavior; Bipolar Disorder; Humans; Inhibition, Psychological; Methylphenidate;

1973