methylphenidate has been researched along with Acute Disease in 17 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylphenidate is a potent central nervous system stimulant that exerts its effects by increasing synaptic levels of dopamine and norepinephrine." | 5.35 | A case of acute cardiomyopathy and pericarditis associated with methylphenidate. ( Dadfarmay, S; Dixon, J, 2009) |
| "Methylphenidate hydrochloride dextroamphetamine sulfate, and levamfetamine succinate have potential as pharmacologic tools for the indirect evaluation of the role of neurotransmitters in schizophrenia." | 5.04 | Methylphenidate, dextroamphetamine, and levamfetamine. Effects on schizophrenic symptoms. ( Davis, JM; Janowsky, DS, 1976) |
| "A 36-year-old patient presented with a severe hand ischemia after intraarterial injection of four dissolved tablets of Methylphenidate each 10 mg (Ritalin into the right radial artery." | 3.72 | [Acute ischemia after intraarterial drug injection]. ( Aschwanden, M; Jäger, KA; Kliem, M; Stürchler, M; Thalhammer, C, 2004) |
| "Methylphenidate is a potent central nervous system stimulant that exerts its effects by increasing synaptic levels of dopamine and norepinephrine." | 1.35 | A case of acute cardiomyopathy and pericarditis associated with methylphenidate. ( Dadfarmay, S; Dixon, J, 2009) |
| "We consider drug-induced cerebral vasculitis as the most likely cause of recurrent ischaemic strokes in the absence of any pathological findings during the diagnostic work-up." | 1.33 | Cerebral vasculitis following oral methylphenidate intake in an adult: a case report. ( Kucinski, T; Röther, J; Thomalla, G; Weiller, C, 2006) |
| "Early signs of Tourette's syndrome may be difficult to distinguish from hyperactive and attention disordered symptoms, leading the clinician to consider treatment with stimulants." | 1.26 | Stimulant medications precipitate Tourette's syndrome. ( Cohen, DJ; Detlor, J; Kremenitzer, MW; Lowe, TL; Shaywitz, BA, 1982) |
| "The authors treated two children with Gilles de la Tourette's disease and one child with a probable combination of Gilles de la Tourette's disease and minimal brain dysfunction with methylphenidate, which resulted in exacerbation of symptoms." | 1.26 | The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children. ( Fras, I; Karlavage, J, 1977) |
| "The clinical diagnosis in 19 cases was minimal brain dysfunction (MBD), and in one case, Gilles de la Tourette syndrome." | 1.26 | Tics following methylphenidate administration. A report of 20 cases. ( Bemporad, JR; Denckla, MB; MacKay, MC, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (41.18) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hegerl, U | 2 |
| Mergl, R | 2 |
| Sander, C | 2 |
| Dietzel, J | 2 |
| Bitter, I | 2 |
| Demyttenaere, K | 2 |
| Gusmão, R | 2 |
| González-Pinto, A | 2 |
| Zorrilla, I | 1 |
| Alocén, AG | 1 |
| Sola, VP | 1 |
| Vieta, E | 2 |
| Juckel, G | 2 |
| Zimmermann, US | 2 |
| Bauer, M | 2 |
| Sienaert, P | 2 |
| Quintão, S | 2 |
| Edel, MA | 2 |
| Bolyos, C | 2 |
| Ayuso-Mateos, JL | 2 |
| López-García, P | 2 |
| Kluge, M | 2 |
| Perez-Sola, V | 1 |
| Waugh, JL | 1 |
| Dadfarmay, S | 1 |
| Dixon, J | 1 |
| McLaren, JL | 1 |
| Cauble, S | 1 |
| Barnett, RJ | 1 |
| Thalhammer, C | 1 |
| Aschwanden, M | 1 |
| Kliem, M | 1 |
| Stürchler, M | 1 |
| Jäger, KA | 1 |
| Thomalla, G | 1 |
| Kucinski, T | 1 |
| Weiller, C | 1 |
| Röther, J | 1 |
| Hollis, CP | 1 |
| Thompson, A | 1 |
| Lowe, TL | 1 |
| Cohen, DJ | 1 |
| Detlor, J | 1 |
| Kremenitzer, MW | 1 |
| Shaywitz, BA | 1 |
| Goldman, MB | 1 |
| Robertson, GL | 1 |
| Luchins, DJ | 1 |
| Hedeker, D | 1 |
| Pandey, GN | 1 |
| Marsteller, DA | 1 |
| Gerasimov, MR | 1 |
| Schiffer, WK | 1 |
| Geiger, JM | 1 |
| Barnett, CR | 1 |
| Schaich Borg, J | 1 |
| Scott, S | 1 |
| Ceccarelli, J | 1 |
| Volkow, ND | 1 |
| Molina, PE | 1 |
| Alexoff, DL | 1 |
| Dewey, SL | 1 |
| Fras, I | 1 |
| Karlavage, J | 1 |
| Janowsky, DS | 2 |
| Davis, JM | 1 |
| Huey, L | 1 |
| Storms, L | 1 |
| Judd, LL | 1 |
| Denckla, MB | 1 |
| Bemporad, JR | 1 |
| MacKay, MC | 1 |
| St Jean, A | 1 |
| Sterlin, C | 1 |
| Noe, W | 1 |
| Ban, TA | 1 |
| Rappaport, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| International Randomised Double-blind Placebo-controlled Study on the Initial Treatment of Acute Mania With Methylphenidate[NCT01541605] | Phase 3 | 42 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for methylphenidate and Acute Disease
| Article | Year |
|---|---|
A multi-centre, randomised, double-blind, placebo-controlled clinical trial of methylphenidate in the initial treatment of acute mania (MEMAP study).
Topics: Acute Disease; Adult; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Female; Humans; Male; | 2018 |
Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate.
Topics: Acute Disease; Adult; Antimanic Agents; Bipolar Disorder; Double-Blind Method; Female; Humans; Male; | 2013 |
Methylphenidate, dextroamphetamine, and levamfetamine. Effects on schizophrenic symptoms.
Topics: Acute Disease; Amphetamines; Clinical Trials as Topic; Dextroamphetamine; Humans; Levodopa; Methylph | 1976 |
Methylphenidate hydrochloride effects on psychological tests in acute schizophrenic and nonpsychotic patients.
Topics: Acute Disease; Adult; Cognition; Female; Holtzman Inkblot Test; Humans; Male; Methylphenidate; MMPI; | 1977 |
Clinical studies with propericiazine (R.P. 8909).
Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin | 1967 |
12 other studies available for methylphenidate and Acute Disease
| Article | Year |
|---|---|
Acute dyskinetic reaction in a healthy toddler following methylphenidate ingestion.
Topics: Acute Disease; Central Nervous System Stimulants; Dyskinesia, Drug-Induced; Humans; Male; Methylphen | 2013 |
A case of acute cardiomyopathy and pericarditis associated with methylphenidate.
Topics: Acute Disease; Adolescent; Angina Pectoris; Attention Deficit Disorder with Hyperactivity; Cardiomyo | 2009 |
Aripiprazole induced acute dystonia after discontinuation of a stimulant medication.
Topics: Acute Disease; Antipsychotic Agents; Aripiprazole; Attention Deficit Disorder with Hyperactivity; Bi | 2010 |
[Acute ischemia after intraarterial drug injection].
Topics: Acute Disease; Adult; Amputation, Surgical; Anti-Inflammatory Agents; Anticoagulants; Central Nervou | 2004 |
Cerebral vasculitis following oral methylphenidate intake in an adult: a case report.
Topics: Acute Disease; Adult; Attention Deficit Disorder with Hyperactivity; Brain; Central Nervous System S | 2006 |
Acute dyskinesia on starting methylphenidate after risperidone withdrawal.
Topics: Acute Disease; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2007 |
Stimulant medications precipitate Tourette's syndrome.
Topics: Acute Disease; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; | 1982 |
Psychotic exacerbations and enhanced vasopressin secretion in schizophrenic patients with hyponatremia and polydipsia.
Topics: Acute Disease; Adult; Arginine Vasopressin; Blood Pressure; Drinking; Female; Heart Rate; Humans; Hy | 1997 |
Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex.
Topics: Acute Disease; Adrenergic Uptake Inhibitors; Animals; Catecholamines; Dopamine; Drug Administration | 2002 |
The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children.
Topics: Acute Disease; Attention Deficit Disorder with Hyperactivity; Catecholamines; Child; Humans; Imipram | 1977 |
Tics following methylphenidate administration. A report of 20 cases.
Topics: Acute Disease; Adolescent; Age Factors; Attention Deficit Disorder with Hyperactivity; Child; Female | 1976 |
Attention to competing voice messages by nonacute schizophrenic patients. Effects of message load, drugs, dosage levels and patient background.
Topics: Acute Disease; Adult; Attention; Auditory Perception; Chlorpromazine; Chronic Disease; Dextroampheta | 1968 |