methylphenidate has been researched along with Abnormalities, Autosome in 11 studies
Methylphenidate: A central nervous system stimulant used most commonly in the treatment of ATTENTION DEFICIT DISORDER in children and for NARCOLEPSY. Its mechanisms appear to be similar to those of DEXTROAMPHETAMINE. The d-isomer of this drug is referred to as DEXMETHYLPHENIDATE HYDROCHLORIDE.
methylphenidate : A racemate comprising equimolar amounts of the two threo isomers of methyl phenyl(piperidin-2-yl)acetate. A central stimulant and indirect-acting sympathomimetic, is used (generally as the hydrochloride salt) in the treatment of hyperactivity disorders in children and for the treatment of narcolepsy.
methyl phenyl(piperidin-2-yl)acetate : A amino acid ester that is methyl phenylacetate in which one of the hydrogens alpha to the carbonyl group is replaced by a piperidin-2-yl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The studies presented in this work were designed to evaluate the genetic toxicity of methylphenidate hydrochloride (MPH) in non-human primates (NHP) using a long-term, chronic dosing regimen." | 1.35 | The genetic toxicology of methylphenidate hydrochloride in non-human primates. ( Bishop, ME; Chen, JJ; Dobrovolsky, VN; Doerge, DR; Hotchkiss, CE; Lin, CJ; Manjanatha, MG; Mattison, DR; Mittelstaedt, RA; Morris, SM; Paule, MG; Petibone, D; Shaddock, JG; Shelton, SD; Slikker, W; Tucker, JD; Twaddle, NC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Witt, KL | 1 |
| Shelby, MD | 1 |
| Itchon-Ramos, N | 1 |
| Faircloth, M | 1 |
| Kissling, GE | 1 |
| Chrisman, AK | 1 |
| Ravi, H | 1 |
| Murli, H | 1 |
| Mattison, DR | 3 |
| Kollins, SH | 2 |
| Morris, SM | 1 |
| Dobrovolsky, VN | 1 |
| Shaddock, JG | 1 |
| Mittelstaedt, RA | 1 |
| Bishop, ME | 1 |
| Manjanatha, MG | 1 |
| Shelton, SD | 1 |
| Doerge, DR | 1 |
| Twaddle, NC | 1 |
| Chen, JJ | 1 |
| Lin, CJ | 1 |
| Paule, MG | 1 |
| Slikker, W | 2 |
| Hotchkiss, CE | 1 |
| Petibone, D | 1 |
| Tucker, JD | 1 |
| Ponsa, I | 1 |
| Ramos-Quiroga, JA | 1 |
| Ribasés, M | 1 |
| Bosch, R | 1 |
| Bielsa, A | 1 |
| Ordeig, MT | 1 |
| Morell, M | 1 |
| Miró, R | 1 |
| de Cid, R | 1 |
| Estivill, X | 1 |
| Casas, M | 1 |
| Bayés, M | 1 |
| Cormand, B | 1 |
| Hervás, A | 1 |
| Goldstein, S | 1 |
| Soto, PL | 1 |
| Wilcox, KM | 1 |
| Zhou, Y | 1 |
| Kumar, A | 1 |
| Ator, NA | 1 |
| Riddle, MA | 1 |
| Wong, DF | 1 |
| Weed, MR | 1 |
| Preston, RJ | 1 |
| Swanson, JM | 1 |
| Greenhill, LL | 1 |
| Wigal, T | 1 |
| Elliott, GR | 1 |
| Vitiello, B | 1 |
| El-Zein, RA | 2 |
| Hay, MJ | 2 |
| Lopez, MS | 2 |
| Bondy, ML | 2 |
| Morris, DL | 2 |
| Legator, MS | 2 |
| Abdel-Rahman, SZ | 2 |
| Jacobson-Kram, D | 1 |
| Mattison, D | 1 |
| Shelby, M | 1 |
| Tice, R | 1 |
| Witt, K | 1 |
| Reeve, A | 1 |
| Shulman, SA | 1 |
| Zimmerman, AW | 1 |
| Cassidy, SB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Measurement of Cytogenetic Endpoints in Lymphocytes of Children Diagnosed With Attention Deficit/Hyperactivity Disorder (ADHD) and Treated With Methylphenidate or Adderall[NCT00341029] | 84 participants | Observational | 2005-12-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for methylphenidate and Abnormalities, Autosome
| Article | Year |
|---|---|
Methylphenidate and amphetamine do not induce cytogenetic damage in lymphocytes of children with ADHD.
Topics: Amphetamines; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Chil | 2008 |
Cytogenetic effects in children treated with methylphenidate.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Child, Pres | 2005 |
9 other studies available for methylphenidate and Abnormalities, Autosome
| Article | Year |
|---|---|
The genetic toxicology of methylphenidate hydrochloride in non-human primates.
Topics: Animals; Body Weight; Cells, Cultured; Chromosome Aberrations; Hypoxanthine Phosphoribosyltransferas | 2009 |
Absence of cytogenetic effects in children and adults with attention-deficit/hyperactivity disorder treated with methylphenidate.
Topics: Adolescent; Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; | 2009 |
Chronic Ritalin use and cancer.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Chromosome Aberrat | 2010 |
Research on cytogenetic risk of ADHD treatments in children.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Chromosome Aberrations; Humans; Methylphenidat | 2010 |
Long-term exposure to oral methylphenidate or dl-amphetamine mixture in peri-adolescent rhesus monkeys: effects on physiology, behavior, and dopamine system development.
Topics: Amphetamine; Animals; Behavior, Animal; Central Nervous System Stimulants; Chromosome Aberrations; D | 2012 |
Comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et al.
Topics: Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Chromosome | 2005 |
Response to comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et al.
Topics: Attention Deficit Disorder with Hyperactivity; Carcinogens; Central Nervous System Stimulants; Child | 2006 |
Methylphenidate and chromosome damage.
Topics: Adolescent; Animals; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulant | 2008 |
Methylphenidate therapy for aggression in a man with ring 22 chromosome. Report and literature review.
Topics: Adult; Aggression; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 21-22 and Y; Hu | 1985 |