methylnitrosourea has been researched along with Stomach Neoplasms in 107 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (26.17) | 18.7374 |
| 1990's | 26 (24.30) | 18.2507 |
| 2000's | 27 (25.23) | 29.6817 |
| 2010's | 19 (17.76) | 24.3611 |
| 2020's | 7 (6.54) | 2.80 |
| Authors | Studies |
|---|---|
| Li, B; Li, K; Liu, H; Wang, A | 1 |
| Bao, C; Bass, AJ; Beroukhim, R; Bronson, R; Duronio, GN; Ferrer-Luna, R; Kikuchi, O; Lazaro, JB; Ligon, KL; Liu, JB; McFarland, JM; Patil, D; Sanchez-Vega, F; Sethi, NS; Sicinska, E; Stachler, MD; Zhang, Y | 1 |
| Chu, TH; Del Portillo, A; Drake, CG; Fox, JG; Hayakawa, Y; Jiang, Z; Kim, W; Nienhüser, H; Remotti, HE; Tomita, H; Wang, TC; White, RA | 1 |
| Li, C; Li, Y; Liu, W | 1 |
| Liu, W; Zhang, J; Zhao, Y | 1 |
| Alharbi, SA; Geng, Z; Liu, J; Shi, Y; Zhang, Y | 1 |
| Jian, Y; Sun, Y; Zhuang, S | 1 |
| Ji, J; Jiang, Y; Liu, X; Qi, X; Ren, J; Yu, Y; Zhang, J; Zhu, Z | 1 |
| Jian, YM; Sun, YN; Zhuang, S | 1 |
| Goldenring, JR; Hosoi, A; Iino, T; Kakimi, K; Matsushita, H; Nagaoka, K; Nomura, S; Saito, T; Seto, Y; Tatematsu, M; Tsukamoto, T; Uchida, E; Yamamoto, M; Yasuda, T | 1 |
| Burbano, RR; DA Rocha, CAM; DE Assumpção, PP; DE Castro Sant' Anna, C; DE Fátima Aquino Moreira Nunes, C; DE Fátima Ferreira Borges DA Costa, J; Lamarão, LM; Muniz, JAPC | 1 |
| Barathidasan, R; Biswas, D; Mansingh, DP; Pradhan, S; Vasanthi, HR | 1 |
| Mori, A; Niwa, T; Tatematsu, M; Toyoda, T; Tsukamoto, T; Ushijima, T | 1 |
| Akanuma, M; Hayakawa, Y; Hikiba, Y; Hirata, Y; Kinoshita, H; Koike, K; Maeda, S; Nakagawa, H; Nakata, W; Sakamoto, K; Sakitani, K; Serizawa, T; Shibata, W; Takahashi, R | 1 |
| Chan, FK; Chan, MT; Chan, RL; Chen, Y; Cheng, AS; Cho, CH; Kang, W; Li, M; Li, MS; Lu, L; Shen, J; Shin, VY; Sung, JJ; To, KF; Tong, JH; Wang, L; Wang, MH; Wong, SH; Wu, WK; Xiao, Z; Yang, W; Yu, J; Zhang, L | 1 |
| Go, DM; Han, SU; Kim, DY; Kim, HK; Kwon, HJ; Lee, SH; Park, JW | 1 |
| Ernst, M; O'Donoghue, RJ; Poh, AR; Putoczki, TL | 1 |
| Hikiba, Y; Karin, M; Maeda, S; Nakagawa, H; Ogura, K; Omata, M; Sakamoto, K; Shibata, W; Yanai, A | 1 |
| Chan, AW; Cheng, AS; Ching, AK; Chong, WW; Chui, YL; Fan, DM; Go, MY; Leung, WK; Sung, JJ; To, KF; Wang, X; Wong, CY; Wu, KC; Yu, J | 1 |
| Ban, H; Cao, XY; Hirata, A; Masegi, T; Oshima, M; Sakai, H; Takasu, S; Tatematsu, M; Toyoda, T; Tsukamoto, T; Yamamoto, M; Yanai, T | 1 |
| Furihata, C; Kaminishi, M; Seto, Y; Shimizu, N; Tatematsu, M; Yamaguchi, H; Yamamoto, M; Yoshizawa, N | 1 |
| Akanuma, M; Hayakawa, Y; Hikiba, Y; Hirata, Y; Kaestner, KH; Maeda, S; Nakagawa, H; Ogura, K; Omata, M; Sakamoto, K; Yanai, A | 1 |
| Hara, A; Hata, K; Hirata, A; Mori, H; Oyama, T; Tomita, H; Ushijima, T; Yamada, Y; Yamashita, S | 1 |
| Betz, KS; Giraud, AS; Jin, G; Kawakami, K; Lerkowit, N; Menheniott, TR; Minamoto, T; Rio, MC; Shibata, W; Takaishi, S; Tomasetto, C; Tomita, H; Varro, A; Wang, TC; Yang, X | 1 |
| Andrade Junior, EF; Assumpção, PP; Burbano, RR; Calcagno, DQ; da Costa, Jde F; Demachki, S; Lacreta Junior, AC; Leal, MF; Muniz, JA; Rabenhorst, SH; Rezende, AP; Silva, TC; Smith, Mde A | 1 |
| Choi, IP; Han, SU; Jee, H; Kang, JS; Kim, DY; Kim, HC; Kwon, HJ; Nam, KH; Nam, KT; Won, YS; Yoon, WK; Yoon, YD | 1 |
| Guo, K; Huang, S; Jia, Z; Kong, X; Le, X; Li, Q; Mishra, L; Tan, D; Wang, L; Wei, D; Xie, K | 1 |
| Klaikeaw, N; Patumraj, S; Sintara, K; Thong-Ngam, D | 1 |
| Ferrero, RL; Sutton, P; Wilson, JE | 1 |
| Choi, YK; Heo, SH; Jeong, DG; Jeong, ES; Kim, DY; Kim, HC; Kwon, HJ; Lee, KS; Seo, JH; Won, YS | 1 |
| Inada, K; Inoue, M; Kaminishi, M; Kumagai, T; Mizoshita, T; Nozaki, K; Shimizu, N; Sugiyama, A; Tatematsu, M; Tsukamoto, T | 1 |
| Cao, X; Kaminishi, M; Kumagai, T; Nozaki, K; Shimizu, N; Tanaka, H; Tatematsu, M; Tsukamoto, T | 1 |
| Cho, SW; Hahm, KB; Han, SU; Kim, DY; Kim, JH; Kim, MW; Kim, YB; Lee, JS; Nahm, KT; Oh, TY; Song, YJ; Surh, YJ; Yoo, BM | 1 |
| Mori, H; Moriwaki, H; Shimizu, M; Suzui, M; Yoshimi, N | 1 |
| Ikehara, Y; Inada, K; Inoue, M; Kaminishi, M; Kumagai, T; Nozaki, K; Shimizu, N; Tanaka, H; Tatematsu, M; Tsukamoto, T | 1 |
| Cao, X; Kaminishi, M; Mizoshita, T; Nozaki, K; Ogasawara, N; Takenaka, Y; Tanaka, H; Tatematsu, M; Tsukamoto, T | 1 |
| Ahn, B; Hahm, KB; Han, SU; Jang, DD; Kang, JS; Kim, DY; Kim, YB; Nam, KT; Oh, SY; Yang, KH; Yeo, M | 1 |
| Mizoshita, T; Tatematsu, M; Tsukamoto, T | 1 |
| Esumi, H; Imamura, K; Ishii, G; Kadowaki, T; Kaminishi, M; Kubota, N; Lu, J; Mafune, K; Nakajima, A; Nomura, S; Ochiai, A; Terauchi, Y | 1 |
| Cao, X; Kaminishi, M; Kato, S; Mizoshita, T; Takenaka, Y; Tatematsu, M; Tsukamoto, T | 1 |
| Asaka, M; Kato, S; Katsuyama, T; Kumagai, T; Mizoshita, T; Ota, H; Tanaka, H; Tatematsu, M; Tsukamoto, T | 1 |
| Kaminishi, M; Nomura, S; Nozaki, K; Shimizu, N; Tatematsu, M; Tsukamoto, T; Yamaguchi, H; Yoshikawa, A | 1 |
| Fukuda, Y; Hori, K; Kawazoe, T; Matsumoto, T; Miwa, H; Nakajima, K; Sakagami, T | 1 |
| Fukushima, S; Imaida, K; Ito, N; Masui, T; Ogiso, T; Shirai, T | 1 |
| Furihata, C; Ito, N; Katsuyama, T; Tatematsu, M; Tsuda, H | 1 |
| Franz, H; Jenssen, HL; Mix, E; Ringel, B; Walzel, H; Ziska, P | 1 |
| Fukushima, S; Imaida, K; Ito, N; Shirai, T; Tatematsu, M; Tsuda, H | 1 |
| Blackwell, BN; Lijinsky, W; Reuber, MD | 1 |
| Edwards, MB; Germain, JP | 1 |
| Reibel, J | 1 |
| Ando, Y; Fujimoto, N; Ito, A; Kanin, GN; Kawamoto, K; Okamoto, T; Watanabe, H; Yamada, K | 1 |
| Jakubczak, J; Merlino, G; Takagi, H; Tamano, S; Ward, JM | 1 |
| Doi, ST; Katsuki, M; Kimura, M | 1 |
| Jang, JJ; Lee, YS | 1 |
| Ando, Y; Ito, A; Okamoto, T; Watanabe, H; Yamada, K | 1 |
| Coccia, JB; Galbraith, AR; Wattenberg, LW | 1 |
| Fukami, H; Kusakabe, N; Masui, T; Nakanishi, H; Sakakura, T; Tatematsu, M; Yamamoto, M | 1 |
| Fukami, H; Iwata, H; Masui, T; Nakanishi, H; Tatematsu, M; Tezuka, N; Yamamoto, M; Yuasa, H | 1 |
| Fukushima, S; Futakuchi, M; Hirose, M; Ito, N; Takahashi, S; Tanaka, H | 1 |
| Fujimitsu, Y; Fukami, H; Inada, K; Kusakabe, M; Masui, T; Nakanishi, H; Tatematsu, M; Yamamoto, M | 1 |
| Inada, K; Masui, T; Miyashita, N; Nakanishi, H; Tatematsu, M; Tezuka, N | 1 |
| Farber, E | 1 |
| Asamoto, M; Hirono, I; Hori, T; Iwahori, Y; Iwase, T; Kim, DJ; Matsumoto, K; Nagao, M; Nishida, Y; Takasuka, N; Tsuda, H; Ushijima, T | 1 |
| Furihata, C; Hattori, M; Inada, K; Ishida, S; Ito, T; Nakanishi, H; Saito, M; Sakaki, Y; Tatematsu, M; Tei, H | 1 |
| Goto, K; Inada, K; Kobayashi, K; Mutai, M; Nakanishi, H; Shimizu, N; Tatematsu, M; Tsukamoto, T | 1 |
| Fukami, H; Ikeno, T; Kaminishi, M; Oohara, T; Shimizu, N; Sugiyama, A; Tatematsu, M; Yamamoto, M; Yoshikawa, A | 1 |
| Ikeno, T; Ishida, K; Katsuyama, T; Kawasaki, S; Maruta, F; Shimizu, N; Sugiyama, A; Tatematsu, M | 1 |
| Fukushima, S; Inada, K; Kobayashi, K; Nakanishi, H; Shimizu, N; Tatematsu, M; Tsukamoto, T; Yamachika, T | 1 |
| Fujino, S; Ichinose, M; Nakanishi, H; Tatematsu, M | 1 |
| Furihata, C; Ikehara, Y; Inada, K; Kobayashi, K; Tatematsu, M; Tsukamoto, T; Yamamoto, M | 1 |
| Hara, A; Kawabata, K; Matsunaga, K; Mori, H; Moriwaki, H; Shimizu, M; Yamada, Y; Yoshimi, N | 1 |
| Ikehara, Y; Inada, K; Kaminishi, M; Katsuyama, T; Kuramoto, S; Nakanishi, H; Nozaki, K; Shimizu, N; Sugiyama, A; Tatematsu, M; Tsukamoto, T | 1 |
| Donehower, LA; Fukuda, M; Huang, H; Ohgaki, H; Stoica, G; Tatematsu, M; Tohma, Y | 1 |
| Nozaki, K; Shimizu, N; Tatematsu, M | 2 |
| Donehower, LA; Furihata, C; Ohgaki, H; Sakai, H; Shirai, N; Tatematsu, M; Tsukamoto, T; Yamamoto, M; Yoshida, K | 1 |
| Ikeno, T; Ishida, K; Katsuyama, T; Kawasaki, S; Maruta, F; Murakami, M; Ota, H; Sugiyama, A; Tatematsu, M | 1 |
| García-González, MA; Morandeira, JR; Morandeira, MJ; Ucar, A | 1 |
| Genta, RM; Katsuyama, T; Kawasaki, S; Maruta, F; Ota, H; Sugiyama, A; Tatematsu, M | 1 |
| Fukuda, Y; Hori, K; Kobayashi, T; Koizuka, H; Nakamura, Y; Sakagami, T; Shimoyama, T; Tanida, N; Yamamoto, N; Yokota, Y | 1 |
| Cho, YK; Hahm, KB; Han, SU; Joo, HJ; Kim, DY; Kim, MW; Kim, YB; Lee, WH | 1 |
| Pfeiffer, CJ | 1 |
| Milievskaia, IL; Vasil'eva, NN | 1 |
| Chorpenning, FW; Filppi, JA; Koestner, A; Rheins, MS; Zwilling, BS | 1 |
| Blaufuss, EM; Mendel, J; Schwarz, H; Thust, R; Warzok, R | 1 |
| Lokich, JJ; Skarin, AT | 1 |
| Bates, RR | 1 |
| Pozharisskiĭ, KM | 1 |
| Haas, H; Hilfrich, J; Ketkar, M; Mohr, U; Reznik, G | 1 |
| Koestner, A; Koestner, AW; Ruecker, FA | 1 |
| Dahme, E; Kalich, J; Stavrou, D | 2 |
| Raineri, R; Weisburger, JH | 1 |
| Rao, MS; Reddy, JK | 1 |
| Cabral, JR; Rossi, L; Terracini, B; Testa, MC | 1 |
| Hoshiya, T; Imaida, K; Ito, N; Kato, T; Ogawa, K; Shichino, Y; Tatematsu, M | 1 |
| Doi, S; Izawa, M; Katsuki, M; Kimura, M; Nishimura, S; Shindo-Okada, N; Takayama, S | 1 |
| Ando, K; Hino, O; Katsuki, M; Kimura, M; Saitoh, A; Takahashi, R | 1 |
| Fukushima, S; Hirose, M; Ito, N; Kato, T; Shibata, MA; Tatematsu, M | 1 |
| Kalinovskiĭ, VP; Pliss, GB; Vol'fson, NI | 1 |
| Hirose, M; Ito, N; Shibata, M; Shirai, T; Tanaka, H | 1 |
| Aonuma, T; Hirota, N; Kawai, T; Saito, K; Yamada, S; Yokoyama, T | 1 |
| Kalinovskiĭ, VP; Petrov, AS; Pliss, GB; Vol'fson, NI; Zaozerskaia, LA | 1 |
| Martin, J; Mendel, J; Schreiber, D; Thust, R | 1 |
| Fukushima, S; Ito, N; Tsuda, H | 1 |
| Martin, J; Mendel, J; Schreiber, D | 1 |
| Hiraki, S | 1 |
11 review(s) available for methylnitrosourea and Stomach Neoplasms
| Article | Year |
|---|---|
Mouse models for gastric cancer: Matching models to biological questions.
Topics: Animals; Disease Models, Animal; Gastrins; Helicobacter felis; Helicobacter Infections; Helicobacter pylori; Methylnitrosourea; Mice, Inbred Strains; Mice, Transgenic; Molecular Targeted Therapy; Stomach Neoplasms | 2016 |
Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible?
Topics: Alanine; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cytokines; Disease Models, Animal; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitrosourea; Mice; NF-kappa B; Quinolones; Stomach Neoplasms; Sulfonamides | 2003 |
Role of Helicobacter pylori in gastric carcinogenesis: the origin of gastric cancers and heterotopic proliferative glands in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Cocarcinogenesis; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Precancerous Conditions; Sodium Chloride, Dietary; Stem Cells; Stomach Neoplasms | 2005 |
[Gastric cancer and eradication of H. pylori].
Topics: Alkylating Agents; Animals; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitrosourea; Stomach Neoplasms | 2007 |
[Eradication model employing Mongolian gerbils treated with chemical carcinogen and infected with Helicobacter pylori--implications for human cancer prevention].
Topics: Adenocarcinoma; Animals; Carcinogens; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms | 2000 |
[The role of Helicobacter pylori infection and effect of eradication in experimental animal models of gastric carcinogenesis].
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Metaplasia; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms | 2001 |
[The epidemiology of gastric cancer (author's transl)].
Topics: Asbestos; Blood Group Antigens; Carcinogens, Environmental; Epidemiologic Methods; Humans; Methylnitrosourea; Nutritional Physiological Phenomena; Sex Factors; Silicon Dioxide; Smoking; Socioeconomic Factors; Stomach Neoplasms | 1976 |
Chemical carcinogenesis and the pancreas.
Topics: 4-Hydroxyaminoquinoline-1-oxide; Adenocarcinoma; Adenoma; Aminoquinolines; Animals; Bile; Carcinogens; Carcinogens, Environmental; Dimethylnitrosamine; Disease Models, Animal; Duodenum; Humans; Liver; Methylnitrosourea; Nitrosamines; Nitrosomethylurethane; Organ Specificity; Pancreas; Pancreatic Ducts; Pancreatic Neoplasms; Precancerous Conditions; Stomach Neoplasms | 1975 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyrenes; Brain Neoplasms; Carcinogens; Cricetinae; Dimethylhydrazines; Dogs; Esophageal Neoplasms; Ethionine; Ethylnitrosourea; Female; Hematopoietic System; Intestinal Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Nitrosoguanidines; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Precancerous Conditions; Rats; Skin Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms | 1975 |
[Dynamics of morphological and biochemical changes in the gastric mucosa in rats during tumor induction].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Gastric Mucosa; Methylcholanthrene; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Rats; Sarcoma, Experimental; Stomach; Stomach Neoplasms | 1990 |
Carcinogenicity and modification of the carcinogenic response by BHA, BHT, and other antioxidants.
Topics: Animals; Anisoles; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Cocarcinogenesis; Drug Synergism; Humans; Kidney Neoplasms; Liver Neoplasms; Methylnitrosourea; Neoplasms; Species Specificity; Stomach Neoplasms; Urinary Bladder Neoplasms | 1985 |
1 trial(s) available for methylnitrosourea and Stomach Neoplasms
| Article | Year |
|---|---|
Nitrosourea combination chemotherapy: 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (methyl-CCNU) and cyclophosphamide.
Topics: Adult; Aged; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Lomustine; Lung Neoplasms; Male; Methylnitrosourea; Middle Aged; Neoplasms; Nitrosourea Compounds; Stomach Neoplasms | 1975 |
95 other study(ies) available for methylnitrosourea and Stomach Neoplasms
| Article | Year |
|---|---|
Protocol for chemically induced murine gastric tumor model.
Topics: Animals; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Stomach; Stomach Neoplasms | 2021 |
Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.
Topics: Adenocarcinoma; Animals; Barrett Esophagus; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Environmental Exposure; Esophageal Neoplasms; Humans; Methylnitrosourea; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; Neoplasms, Experimental; Organoids; Precancerous Conditions; Stomach Neoplasms; Tumor Suppressor Protein p53 | 2020 |
PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice.
Topics: Administration, Oral; Animals; Carcinogenesis; Gastric Mucosa; Gastrins; Helicobacter felis; Helicobacter Infections; Humans; Immune Checkpoint Inhibitors; Methylnitrosourea; Mice; Mice, Knockout; Myeloid-Derived Suppressor Cells; Neoplasms, Experimental; Programmed Cell Death 1 Receptor; Signal Transduction; Stomach Neoplasms; Tumor Microenvironment | 2021 |
Kirenol Exhibits the Protective Role against N-Methyl-N-Nitrosourea-Induced Gastric Cancer in Rats via Modulating the Oxidative Stress and Inflammatory Markers.
Topics: Animals; Biomarkers; Dinoprostone; Diterpenes; Gastric Mucosa; Interleukin-6; Lipid Peroxidation; Male; Methylnitrosourea; NF-kappa B; Oxidative Stress; Rats; Rats, Wistar; Stomach Neoplasms; Tumor Necrosis Factor-alpha | 2020 |
Diosmin Regulates Oxidative Stress and Inflammatory Marker Levels in N-Methyl-N-Nitrosourea-Induced Gastric Carcinogenesis in Rats.
Topics: Animals; Biomarkers; Carcinogenesis; Cytokines; Diosmin; Gastric Mucosa; Male; Methylnitrosourea; Oxidative Stress; Rats; Rats, Wistar; Stomach Neoplasms | 2020 |
Sesquiterpenoid bilobalide inhibits gastric carcinoma cell growth and induces apoptosis both in vitro and in vivo models.
Topics: Animals; Apoptosis; Bilobalides; Cell Line, Tumor; Cell Proliferation; Ginkgo biloba; Humans; Male; Methylnitrosourea; Neoplasms, Experimental; Plant Extracts; Rats; Rats, Wistar; Stomach Neoplasms | 2021 |
Metformin Inhibits N-Methyl-N-Nitrosourea Induced Gastric Tumorigenesis in db/db Mice.
Topics: Animals; Insulin; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Male; Metformin; Methylnitrosourea; Mice; Mice, Inbred NOD; Neoplasm Proteins; Stomach Neoplasms | 2017 |
Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Damage; DNA Repair; F-Box-WD Repeat-Containing Protein 7; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Gene Order; Gene Targeting; Genes, myc; Genetic Loci; Genetic Predisposition to Disease; Genotype; Haploinsufficiency; Methylnitrosourea; Mice; Mice, Knockout; Models, Biological; Stomach Neoplasms | 2017 |
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice.
Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Carcinogenesis; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Immunohistochemistry; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Ki-67 Antigen; Leptin; Male; Methylnitrosourea; Mice; Stomach Neoplasms | 2017 |
Established gastric cancer cell lines transplantable into C57BL/6 mice show fibroblast growth factor receptor 4 promotion of tumor growth.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Gene Knockout Techniques; Immunocompetence; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Metastasis; Neoplasm Transplantation; Receptor, Fibroblast Growth Factor, Type 4; Stomach Neoplasms; Tumor Suppressor Protein p53 | 2018 |
Deregulation of the SRC Family Tyrosine Kinases in Gastric Carcinogenesis in Non-human Primates.
Topics: Animals; Cebus; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Methylnitrosourea; Neoplasm Metastasis; src-Family Kinases; Stomach Neoplasms; Up-Regulation | 2018 |
Palliative Role of Aqueous Ginger Extract on
Topics: Alkylating Agents; Animals; Disease Models, Animal; Glutathione Peroxidase; Humans; Lipid Peroxidation; Male; Methylnitrosourea; Neoplasms, Experimental; Oxidative Stress; Palliative Care; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Stomach Neoplasms; Zingiber officinale | 2020 |
Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent.
Topics: Adenocarcinoma; Animals; Azacitidine; Carcinogens; Decitabine; Disease Models, Animal; DNA Methylation; DNA-Cytosine Methylases; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Stomach Neoplasms | 2013 |
Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis.
Topics: Animals; Cell Communication; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Culture Media, Conditioned; Disease Models, Animal; Epithelial Cells; Fibroblasts; Humans; Interleukin-6; Methylnitrosourea; Mice; Models, Biological; Neoplastic Stem Cells; STAT3 Transcription Factor; Stomach Neoplasms; Stromal Cells | 2013 |
Epigenetic silencing of miR-490-3p reactivates the chromatin remodeler SMARCD1 to promote Helicobacter pylori-induced gastric carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogenesis; Cell Line, Tumor; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Helicobacter pylori; Humans; Metaplasia; Methylnitrosourea; Mice; MicroRNAs; Stomach Neoplasms | 2015 |
Ablation of osteopontin suppresses N-methyl-N-nitrosourea and Helicobacter pylori-induced gastric cancer development in mice.
Topics: Animals; Apoptosis; Cell Line, Tumor; Coculture Techniques; Gastric Mucosa; Gene Knockout Techniques; Helicobacter Infections; Humans; Male; Methylnitrosourea; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type II; Osteopontin; Signal Transduction; STAT1 Transcription Factor; Stomach Neoplasms | 2015 |
c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase 8; Stomach Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Transgenic cyclooxygenase-2 expression and high salt enhanced susceptibility to chemical-induced gastric cancer development in mice.
Topics: Animals; Apoptosis; Cell Division; Cyclooxygenase 2; DNA; Female; Genetic Predisposition to Disease; Humans; Methylnitrosourea; Mice; Mice, Transgenic; Oviducts; Pseudopregnancy; Sodium Chloride, Dietary; Stomach Neoplasms | 2008 |
Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice.
Topics: Animals; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Cyclooxygenase 2; Enzyme Activation; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Immunohistochemistry; Intramolecular Oxidoreductases; Methylnitrosourea; Mice; Mice, Transgenic; Microsomes; Prostaglandin-E Synthases; Random Allocation; Stomach Neoplasms | 2008 |
Gastric carcinogenesis by N-Methyl-N-nitrosourea is enhanced in db/db diabetic mice.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Diabetes Complications; Disease Models, Animal; Gastric Mucosa; Insulin; Leptin; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Precancerous Conditions; Stomach Neoplasms | 2009 |
Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; I-kappa B Kinase; Interleukin-1alpha; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Receptors, Interleukin-1; Stomach Neoplasms | 2010 |
Suppressive effect of global DNA hypomethylation on gastric carcinogenesis.
Topics: Animals; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Genes, APC; Humans; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Stomach Neoplasms | 2010 |
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.
Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Disease Models, Animal; DNA Methylation; Female; Gastrins; Gene Expression Regulation, Neoplastic; Gene Silencing; Helicobacter felis; Helicobacter Infections; Histones; Humans; Male; Methylnitrosourea; Mice; Mice, Knockout; Middle Aged; Neoplastic Stem Cells; Peptides; Promoter Regions, Genetic; RNA, Messenger; Stomach Neoplasms; Time Factors; Transfection; Trefoil Factor-1; Tumor Suppressor Proteins | 2011 |
Experimental gastric carcinogenesis in Cebus apella nonhuman primates.
Topics: Animals; Cebus; Cell Line; Crotalid Venoms; Disease Models, Animal; Gene Dosage; Gene Expression Regulation, Neoplastic; Immunohistochemistry; In Situ Hybridization, Fluorescence; Methylnitrosourea; Neoplasms, Experimental; Plant Extracts; Proto-Oncogene Proteins c-myc; RNA, Messenger; Stomach Neoplasms; Ultrasonography | 2011 |
Vitamin D₃ upregulated protein 1 deficiency promotes N-methyl-N-nitrosourea and Helicobacter pylori-induced gastric carcinogenesis in mice.
Topics: Animals; Biomarkers, Tumor; Carrier Proteins; Cell Growth Processes; Cell Line, Tumor; Cyclooxygenase 2; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Random Allocation; Stomach Neoplasms; Thioredoxins; Tissue Array Analysis; Tumor Necrosis Factor-alpha | 2012 |
Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Forkhead Box Protein M1; Forkhead Transcription Factors; Gastric Mucosa; Genotype; Humans; Integrases; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microfilament Proteins; Neoplastic Stem Cells; Phenotype; Precancerous Conditions; Promoter Regions, Genetic; Pyloric Antrum; Stomach Neoplasms; Time Factors | 2012 |
Curcumin attenuates gastric cancer induced by N-methyl-N-nitrosourea and saturated sodium chloride in rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Analysis of Variance; Animals; Antineoplastic Agents; Curcumin; Cyclin D1; Deoxyguanosine; I-kappa B Proteins; Immunohistochemistry; Male; Methylnitrosourea; Rats; Rats, Wistar; Sodium Chloride; Stomach Neoplasms | 2012 |
Mouse models of Helicobacter-induced gastric cancer: use of cocarcinogens.
Topics: Animals; Carcinogens; Cell Proliferation; Culture Media; Culture Techniques; Cytokines; Disease Models, Animal; Drug Interactions; Epithelial Cells; Female; Helicobacter pylori; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Microbial Viability; Polymerase Chain Reaction; Specimen Handling; Stomach Neoplasms; Urease | 2012 |
Canonical Wnt signaling pathway plays an essential role in N-methyl-N-nitrosurea induced gastric tumorigenesis of mice.
Topics: Animals; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Methylnitrosourea; Mice; RNA, Messenger; Stomach Neoplasms; Wnt Signaling Pathway | 2013 |
Synergistic promoting effects of Helicobacter pylori infection and high-salt diet on gastric carcinogenesis in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Sodium Chloride, Dietary; Stomach Neoplasms | 2002 |
Earlier Helicobacter pylori infection increases the risk for the N-methyl-N-nitrosourea-induced stomach carcinogenesis in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Antibodies, Bacterial; Gastrins; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Immunoglobulin G; Male; Methylnitrosourea; Risk; Stomach Neoplasms | 2002 |
No involvement of beta-catenin gene mutation in gastric carcinomas induced by N-methyl-N-nitrosourea in male F344 rats.
Topics: Adenocarcinoma; Adenocarcinoma, Papillary; Animals; beta Catenin; Carcinogens; Cell Membrane; Cell Nucleus; Codon; Cytoplasm; Cytoskeletal Proteins; DNA Mutational Analysis; DNA, Neoplasm; Male; Membrane Proteins; Methylnitrosourea; Phosphorylation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred F344; Stomach Neoplasms; Trans-Activators | 2003 |
Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils.
Topics: Animals; Anti-Bacterial Agents; Carcinoid Tumor; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Incidence; Methylnitrosourea; Stomach Neoplasms | 2003 |
Beta-catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils.
Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Base Sequence; beta Catenin; Cytoskeletal Proteins; Exons; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Molecular Sequence Data; Mutation; Stomach Neoplasms; Trans-Activators | 2004 |
The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; In Situ Nick-End Labeling; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms; Sulfonamides | 2004 |
Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Chromans; Female; Gastric Mucosa; Ligands; Male; Methylnitrosourea; Mice; Mice, Knockout; PPAR gamma; Stomach Neoplasms; Thiazolidinediones; Troglitazone | 2005 |
Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils.
Topics: Animals; Carcinogens; Cell Differentiation; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Intestines; Methylnitrosourea; Neoplasm Staging; Neoplasms, Glandular and Epithelial; Phenotype; Stomach Neoplasms | 2006 |
High salt diets dose-dependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cells.
Topics: Adenocarcinoma; Amino Acid Sequence; Animal Feed; Animals; Base Sequence; Body Weight; Cell Transformation, Neoplastic; Cloning, Molecular; Conserved Sequence; Dose-Response Relationship, Drug; Gastric Mucosa; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Molecular Sequence Data; Mongolia; Mucins; Sequence Alignment; Sodium Chloride; Stomach Neoplasms | 2006 |
Role of bacterial strain diversity of Helicobacter pylori in gastric carcinogenesis induced by N-methyl-N-nitrosourea in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Disease Models, Animal; Gastritis; Gerbillinae; Helicobacter pylori; Methylnitrosourea; Mice; Mice, Inbred C57BL; Stomach Neoplasms | 2007 |
Promoting activities of butylated hydroxyanisole, butylated hydroxytoluene and sodium L-ascorbate on forestomach and urinary bladder carcinogenesis initiated with methylnitrosourea in F344 male rats.
Topics: Animals; Anisoles; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Hyperplasia; Male; Methylnitrosourea; Papilloma; Rats; Rats, Inbred F344; Stomach; Stomach Neoplasms; Urinary Bladder Neoplasms | 1984 |
Stable intestinal phenotypic expression of gastric and small intestinal tumor cells induced by N-methyl-N'-nitro-N-nitrosoguanidine or methylnitrosourea in rats.
Topics: Adenocarcinoma; Animals; Gastric Mucosa; Hyperplasia; Intestinal Neoplasms; Intestines; Male; Metaplasia; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Phenotype; Rats; Rats, Inbred Strains; Stomach Neoplasms | 1984 |
Immunological reactivity of tumor associated glycoproteins prepared by affinity chromatography.
Topics: Adenocarcinoma; Animals; Antigens, Neoplasm; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Fibrosarcoma; Glycoproteins; Humans; Methylnitrosourea; Mice; Mice, Inbred CBA; Neoplasm Proteins; Neoplasm Transplantation; Stomach Neoplasms | 1984 |
Modification of chemical carcinogenesis by antioxidants.
Topics: Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Ethoxyquin; Kidney Neoplasms; Liver Neoplasms; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Stomach Neoplasms; Urinary Bladder Neoplasms | 1983 |
Carcinogenicity of nitrosotrialkylureas in Fischer 344 rats.
Topics: Animals; Astrocytoma; Brain Neoplasms; Carcinogens; Diet; Dose-Response Relationship, Drug; Female; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Spinal Cord Neoplasms; Stomach Neoplasms | 1980 |
Oral carcinogenesis by intragastric N-methyl-N-nitrosourea in the Syrian hamster.
Topics: Animals; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Mesocricetus; Methylnitrosourea; Mouth Neoplasms; Nitrosourea Compounds; Stomach Neoplasms | 1980 |
Carcinogenesis in forestomach and changes in oral mucosa of rats induced by intragastric N-methylnitrosourea.
Topics: Animals; Methylnitrosourea; Mouth Neoplasms; Neoplasms, Experimental; Nitrosourea Compounds; Precancerous Conditions; Rats; Rats, Inbred Strains; Stomach Neoplasms; Time Factors | 1982 |
Elevated serum growth hormone accelerates gastric tumorigenesis in F344 rats after treatment with N-methyl-N-nitrosourea in their drinking water.
Topics: Animals; Body Weight; Carcinogens; Drinking; Growth Hormone; Iodine Radioisotopes; Male; Methylnitrosourea; Neoplasm Transplantation; Organ Size; Pituitary Neoplasms; Rats; Rats, Inbred F344; Stomach Neoplasms; Thyroidectomy; Time Factors | 1995 |
Increased susceptibility to N-nitrosomethylurea gastric carcinogenesis in transforming growth factor alpha transgenic mice with gastric hyperplasia.
Topics: Adenocarcinoma; Animals; Female; Hyperplasia; Immunohistochemistry; Male; Methylnitrosourea; Mice; Mice, Transgenic; Pepsinogens; Precancerous Conditions; Stomach; Stomach Neoplasms; Transforming Growth Factor alpha | 1995 |
Site-specific mutation of the human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Squamous Cell; Codon; Genes, ras; Hemangiosarcoma; Humans; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Transgenic; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Point Mutation; Polymerase Chain Reaction; Promoter Regions, Genetic; Splenic Neoplasms; Stomach Neoplasms | 1994 |
Potent promoting activity of dimethylitaconate on gastric carcinogenesis induced by N-methylnitrosourea.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Cell Division; Drug Synergism; Enzyme Induction; Hyperplasia; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Stomach Neoplasms; Succinates | 1994 |
Lack of any positive effect of intestinal metaplasia on induction of gastric tumors in Wistar rats treated with N-methyl-N-nitrosourea in their drinking water.
Topics: Adenocarcinoma; Administration, Oral; Alkaline Phosphatase; Animals; Intestines; Male; Metaplasia; Methylnitrosourea; Radiation Injuries, Experimental; Rats; Rats, Wistar; Stomach Neoplasms | 1994 |
Inhibition of carcinogen-induced pulmonary and mammary carcinogenesis by chalcone administered subsequent to carcinogen exposure.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Chalcone; Female; Lung Neoplasms; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred A; Rats; Rats, Sprague-Dawley; Stomach Neoplasms | 1994 |
Clonal analysis of glandular stomach carcinogenesis in C3H/HeN<==>BALB/c chimeric mice treated with N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Chimera; Clone Cells; Female; Hyperplasia; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Stomach Neoplasms | 1994 |
Induction of glandular stomach cancers in C3H mice treated with N-methyl-N-nitrosourea in the drinking water.
Topics: Adenocarcinoma; Animals; Carcinoma, Signet Ring Cell; Diet; Disease Models, Animal; Hyperplasia; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Stomach Neoplasms | 1993 |
Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model.
Topics: Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinoma in Situ; Carcinoma, Squamous Cell; Catechols; Cocarcinogenesis; Dimethylhydrazines; Disease Models, Animal; Drug Interactions; Eating; Epithelium; Hyperplasia; Liver; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Size; Rats; Rats, Inbred F344; Sodium Nitrite; Stomach; Stomach Neoplasms | 1993 |
Monoclonal development of squamous cell carcinomas from polyclonal papillary or nodular hyperplasias in the forestomach of C3H/HeN<-->BALB/c chimeric mice treated with N-methyl-N-nitrosourea or diethylnitrosamine.
Topics: Animals; Antibody Specificity; Carcinogens; Carcinoma, Squamous Cell; Carrier Proteins; Chimera; Diethylnitrosamine; DNA, Neoplasm; DNA, Satellite; Epitopes; HSP70 Heat-Shock Proteins; Hyperplasia; Immunohistochemistry; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred ICR; Mice, Transgenic; Polymorphism, Genetic; Species Specificity; Stomach; Stomach Neoplasms | 1996 |
Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; DNA Mutational Analysis; Gene Deletion; Genes, p53; Genes, ras; Genes, Tumor Suppressor; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Stomach Neoplasms | 1997 |
Monoclonal and polyclonal development of digestive tract tumors in chimeric mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carrier Proteins; Chimera; Colonic Neoplasms; Diethylnitrosamine; Digestive System Neoplasms; Dimethylhydrazines; HSP70 Heat-Shock Proteins; Immunohistochemistry; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Proteins; Precancerous Conditions; Stomach Neoplasms | 1997 |
Demonstration of ras and p53 gene mutations in carcinomas in the forestomach and intestine and soft tissue sarcomas induced by N-methyl-N-nitrosourea in the rat.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Genes, p53; Genes, ras; Intestinal Neoplasms; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Papilloma; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred F344; Sarcoma, Experimental; Sequence Analysis, DNA; Stomach Neoplasms | 1997 |
Rare occurrence of ras and p53 gene mutations in mouse stomach tumors induced by N-methyl-N-nitrosourea.
Topics: Adenoma; Animals; Carcinoma; Genes, p53; Genes, ras; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mutagenesis; Stomach Neoplasms | 1997 |
Dose-dependent promoting effects of catechol on glandular stomach carcinogenesis in BALB/c mice initiated with N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Carcinogens; Catechols; Dose-Response Relationship, Drug; Female; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Pylorus; Rats; Stomach Neoplasms | 1997 |
Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine in drinking water.
Topics: Adenocarcinoma; Administration, Oral; Animals; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Disease Susceptibility; Drinking; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms; Water | 1998 |
Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil.
Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Signet Ring Cell; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Stomach Neoplasms | 1998 |
N-methyl-N-nitrosourea concentration-dependent, rather than total intake-dependent, induction of adenocarcinomas in the glandular stomach of BALB/c mice.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Drug Administration Schedule; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Stomach Neoplasms; Survival Rate | 1998 |
Establishment and characterization of two cell lines from N-methyl-N-nitrosourea-induced mouse glandular stomach carcinomas.
Topics: Adenocarcinoma; Animals; Carcinogens; Cathepsin E; Cathepsins; Cell Differentiation; Cell Division; Immunohistochemistry; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pepsinogens; Stomach Neoplasms; Tumor Cells, Cultured | 1998 |
Effects of low dose catechol on glandular stomach carcinogenesis in BALB/c mice initiated with N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Catechols; Disease Models, Animal; Dose-Response Relationship, Drug; Gastric Mucosa; Humans; Immunohistochemistry; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Pepsinogen A; Stomach Neoplasms | 1999 |
Suppressive effects of chlorogenic acid on N-methyl-N-nitrosourea-induced glandular stomach carcinogenesis in male F344 rats.
Topics: Animals; Carcinogens; Chlorogenic Acid; Immunohistochemistry; Male; Methylnitrosourea; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344; Stomach Neoplasms | 1999 |
Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Signet Ring Cell; Cocarcinogenesis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Pyloric Antrum; Stomach Neoplasms; Survival Rate | 2000 |
Effect of intragastric application of N-methylnitrosourea in p53 knockout mice.
Topics: Adenocarcinoma; Alleles; Animals; Carcinogens; Female; Genes, p53; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Sarcoma, Experimental; Stomach; Stomach Neoplasms | 2000 |
p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.
Topics: Animals; Carcinogens; Cocarcinogenesis; Female; Gastric Mucosa; Gene Dosage; Genes, p53; Genetic Predisposition to Disease; Heterozygote; Male; Methylnitrosourea; Mice; Mice, Knockout; Mutation; Pepsinogen A; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Precancerous Conditions; Stomach Neoplasms; Tumor Suppressor Protein p53 | 2000 |
Timing of N-methyl-N-nitrosourea administration affects gastric carcinogenesis in Mongolian gerbils infected with Helicobacter pylori.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Bromodeoxyuridine; Gastric Mucosa; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Intestines; Metaplasia; Methylnitrosourea; Stomach Neoplasms; Time Factors | 2000 |
A new model for the induction of tumours in the forestomach of rats by N-methyl-N-nitrosourea.
Topics: Animals; Carcinogens; Carcinoma; Female; Male; Methylnitrosourea; Papilloma; Rats; Rats, Wistar; Stomach Neoplasms; Time Factors | 2000 |
Role of N-methyl-N-nitrosourea in the induction of intestinal metaplasia and gastric adenocarcinoma in Mongolian gerbils infected with Helicobacter pylori.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Immunohistochemistry; Intestinal Mucosa; Intestinal Neoplasms; Male; Methylnitrosourea; Precancerous Conditions; Probability; Reference Values; Severity of Illness Index; Statistics, Nonparametric; Stomach Neoplasms | 2001 |
Helicobacter pylori does not promote N-methyl-N-nitrosourea-induced gastric carcinogenesis in SPF C57BL/6 mice.
Topics: Animals; Disease Models, Animal; Gastritis; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Specific Pathogen-Free Organisms; Stomach Neoplasms | 2002 |
Helicobacter pylori infection promotes gastric carcinogenesis in a mice model.
Topics: Adenocarcinoma; Adenoma; Animals; Female; Gastric Mucosa; Gastritis, Atrophic; Helicobacter Infections; Helicobacter pylori; Methylnitrosourea; Mice; Mice, Inbred C57BL; Proliferating Cell Nuclear Antigen; Stomach Neoplasms | 2002 |
[Neurogenic stomach neoplasms induced by nitrosomethylures in Syrian hamsters].
Topics: Animals; Cricetinae; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Nerve Tissue; Papilloma; Rhabdomyosarcoma; Stomach Neoplasms | 1977 |
Chemical carcinogenesis and immunity: immunologic status of rats treated with methylnitrosourea.
Topics: Animals; Antibody Formation; Hyperplasia; Immunity; Immunosuppression Therapy; Lymphocytes; Lymphoid Tissue; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Stomach Neoplasms; Teichoic Acids | 1978 |
Methylnitrosophenylurea--a highly carcinogenic compound.
Topics: Animals; Carcinogens, Environmental; Carcinoma, Squamous Cell; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Rats; Stomach Neoplasms | 1978 |
Tumors of the heart and stomach induced in European hamsters by intravenous administration of N-methyl-N-nitrosourea.
Topics: Animals; Cricetinae; Female; Fibrosarcoma; Heart Neoplasms; Injections, Intravenous; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Sex Factors; Stomach Neoplasms | 1977 |
Morphology and pathogenesis of tumors of the thymus and stomach in Sprague-Dawley rats following intragastric administration of methyl nitrosourea (MNU).
Topics: Animals; Lymphoma; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Stomach Neoplasms; Thymus Neoplasms; Time Factors | 1977 |
[Induction of tumors of the stomach in mini-pigs by methylnitrosourea administration (author's transl)].
Topics: Anaplasia; Animals; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Organ Specificity; Polyps; Species Specificity; Stomach Neoplasms; Swine | 1976 |
Reduction of gastric carcinogens with ascorbic acid.
Topics: Ascorbic Acid; Humans; Methylnitrosourea; Methylurea Compounds; Models, Biological; Nitrates; Nitrites; Plants; Stomach Neoplasms; Vegetables | 1975 |
Pancreatic adenocarcinoma in inbred guinea pigs induced by n-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Female; Guinea Pigs; Intestinal Neoplasms; Lymphoma; Male; Mesentery; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pancreas; Pancreatic Ducts; Pancreatic Neoplasms; Sex Factors; Stomach Neoplasms; Time Factors | 1975 |
[Proceedings: Experimental induction of gastric tumors in the miniature swine].
Topics: Animals; Intestinal Polyps; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Species Specificity; Stomach Neoplasms; Swine | 1975 |
The roles of age at treatment and dose in carcinogenesis in C3Hf/Dp mice with a single administration of N-nitroso-N-methylurea.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitrosourea Compounds; Stomach Neoplasms; Thymus Neoplasms | 1976 |
Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Stomach Neoplasms; Time Factors | 1992 |
Inhibition of chemical carcinogenesis in vivo by azatyrosine.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Alanine; Animals; Antibiotics, Antineoplastic; Drug Screening Assays, Antitumor; Genes, ras; Methylnitrosourea; Mice; Mutation; Papilloma; Skin Neoplasms; Stomach Neoplasms | 1992 |
Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes.
Topics: Animals; Base Sequence; Dose-Response Relationship, Drug; Gene Expression; Genes, ras; Humans; Lymphoma; Methylnitrosourea; Mice; Mice, Transgenic; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Papilloma; Polymerase Chain Reaction; Proto-Oncogene Proteins p21(ras); Skin Neoplasms; Stomach Neoplasms | 1992 |
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Pepsinogens; Pylorus; Rats; Rats, Inbred F344; Stomach Neoplasms; Urinary Bladder Neoplasms | 1991 |
Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2'-dimethyl-4-aminobiphenyl, 2,2'-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea.
Topics: Aminobiphenyl Compounds; Animals; Body Weight; Butylated Hydroxyanisole; Carcinogens; Hyperplasia; Kidney; Liver; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Stomach Neoplasms; Tongue Neoplasms; Urinary Bladder Neoplasms | 1989 |
Selective induction of glandular stomach carcinoma in F344 rats by N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Drinking; Methylnitrosourea; Ossification, Heterotopic; Rats; Rats, Inbred F344; Stomach Neoplasms | 1987 |
[Stomach tumors in rats induced by a single administration of N-methyl-N-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea].
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Papilloma; Precancerous Conditions; Rats; Sarcoma, Experimental; Stomach Neoplasms | 1988 |
High local carcinogenic activity of 1,3-dimethyl-3-phenyl-1-nitrosourea and its inactivation by intravenous application in rats: comparison of in vivo findings with the in vitro direct and a combined in vivo/in vitro sister chromatid exchange assay in V79
Topics: Animals; Carcinoma, Squamous Cell; Cells, Cultured; Cricetinae; Female; Inactivation, Metabolic; Injections, Intravenous; Intubation, Gastrointestinal; Male; Methylnitrosourea; Mutagenicity Tests; Rats; Sister Chromatid Exchange; Stomach Neoplasms | 1987 |
Carcinogenicity of 1-methyl-3(p-chlorophenyl)-1-nitrosourea and its 1-methyl trideuterated derivative in rats.
Topics: Animals; Carcinogens; Intubation, Gastrointestinal; Methylnitrosourea; Rats; Rats, Inbred Strains; Reaction Time; Stomach Neoplasms | 1986 |
N,N'-dimethylnitrosourea-induced tumors in mice and Syrian hamsters.
Topics: Animals; Cricetinae; Female; Injections, Subcutaneous; Lung Neoplasms; Lymphoma; Male; Mammary Neoplasms, Experimental; Mediastinal Neoplasms; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Retroviridae; Stomach Neoplasms; Thymus Neoplasms; Transplantation, Homologous | 1974 |