methylnitrosourea has been researched along with Experimental Neoplasms in 320 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 234 (73.13) | 18.7374 |
| 1990's | 52 (16.25) | 18.2507 |
| 2000's | 22 (6.88) | 29.6817 |
| 2010's | 7 (2.19) | 24.3611 |
| 2020's | 5 (1.56) | 2.80 |
| Authors | Studies |
|---|---|
| Li, B; Li, K; Liu, H; Wang, A | 1 |
| Bao, C; Bass, AJ; Beroukhim, R; Bronson, R; Duronio, GN; Ferrer-Luna, R; Kikuchi, O; Lazaro, JB; Ligon, KL; Liu, JB; McFarland, JM; Patil, D; Sanchez-Vega, F; Sethi, NS; Sicinska, E; Stachler, MD; Zhang, Y | 1 |
| Chu, TH; Del Portillo, A; Drake, CG; Fox, JG; Hayakawa, Y; Jiang, Z; Kim, W; Nienhüser, H; Remotti, HE; Tomita, H; Wang, TC; White, RA | 1 |
| Alharbi, SA; Geng, Z; Liu, J; Shi, Y; Zhang, Y | 1 |
| Barathidasan, R; Biswas, D; Mansingh, DP; Pradhan, S; Vasanthi, HR | 1 |
| Ding, H; Feng, G; Li, J; Lin, D; Liu, T; Luo, F; Ma, P; Wang, J; Xu, Y; Yang, K | 1 |
| Elmore, SA; Emoto, Y; Kinoshita, Y; Tsubura, A; Yoshizawa, K; Yuki, M; Yuri, T | 1 |
| Colarusso, C; Pinto, A; Popolo, A; Sorrentino, R; Terlizzi, M | 1 |
| Machida, K; Nomura, T; Tsutsumi, H; Urano, K; Usui, T; Yoshimura, M | 1 |
| Huang, RF; Wu, ZZ; Yu, YH | 1 |
| Long, GG; Morton, D; Peters, T; Short, B; Skydsgaard, M | 1 |
| Fan, SY; Wu, ZZ; Yu, YH | 1 |
| Andrade Junior, EF; Assumpção, PP; Burbano, RR; Calcagno, DQ; da Costa, Jde F; Demachki, S; Lacreta Junior, AC; Leal, MF; Muniz, JA; Rabenhorst, SH; Rezende, AP; Silva, TC; Smith, Mde A | 1 |
| Eto, T; Hiraoka, M; Hirota, K; Inoue, M; Ito, M; Kadonosono, T; Kizaka-Kondoh, S; Kondoh, G; Kuchimaru, T; Machida, K; Murakami, A; Ogura, T; Takahashi, Y; Tanaka, T; Tani, T; Toyoda, T; Tsukamoto, T; Tsutsumi, H; Urano, K; Watanabe, H; Yamada, S | 1 |
| Ali, EM; Amin, AA; Helal, TE; Khalifa, AA; Mabrouk, GM; Moselhy, SS; Zohny, SF | 1 |
| Ishimura, Y; Kashiwabara, S; Katoh, O; Lu, H; Shiraki, K; Uesaka, T; Watanabe, H | 1 |
| Furukawa, F; Hirose, M; Imazawa, T; Natsume, M; Nishikawa, A; Okazaki, K; Osakabe, N; Yamagishi, M | 1 |
| Cagatay, P; Kalkan, MT; Shimamoto, F; Tuncel, H | 1 |
| Adlercreutz, H; Berger, MR; Elger, W; Lippert, TH; Mueck, AO; Seeger, H | 1 |
| Ahmad, I; Bhamra, R; Bolcsak, LE; Cavanaugh, C; Roberts, P; Schupsky, J; Stevens, R; Swenson, CE | 1 |
| DRUCKREY, H; IVANKOVIC, S; PREUSSMANN, R; STEINHOFF, D | 1 |
| DRUCKREY, H; IVANKOVIC, S; PREUSSMANN, R | 1 |
| Binderup, L; Bramm, E; Colston, KW; Hamberg, KJ; Pirianov, G | 1 |
| Blasco, MA; Flores, JM; González-Suárez, E; Goytisolo, FA | 1 |
| Kitajima, Y; Koga, Y; Kohya, N; Miyazaki, K; Miyoshi, A; Sato, K | 1 |
| Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW; Roomi, NW | 1 |
| Eguchi, N; Fukasawa, K; Kikuchi, K; Machida, K; Sawa, N; Suzuki, S; Taguchi, F; Urano, K; Usui, T | 1 |
| Elling, H; Stavrou, D | 1 |
| Bilzer, T; Hultén, M; Stavrou, D | 1 |
| Althoff, J; Green, U; Schneider, P; Soudah, B | 1 |
| Strukelj, B | 1 |
| Bosland, MC; Kroes, R; Prinsen, MK | 1 |
| Anzil, AP; Haglid, KG; Isenberg, G; Rieske, E; Stavrou, D | 1 |
| Jänisch, W; Schmidt, T | 1 |
| Alexandrov, VA; Timoshenko, IV; Turusov, VS | 1 |
| Benfield, JR; Cohen, AH; Fu, PC; Hammond, WG; Jensen, T; Pak, HY; Paladugu, RR; Shors, EC; Teplitz, RL | 1 |
| Dorsch-Häsler, K; Mayer, A | 1 |
| Hodges, GM; Nathrath, WJ; Summerhayes, IC; Trejdosiewicz, LK; Wilson, PD | 1 |
| McCallum, L; Nissenkorn, I; Soloway, MS | 1 |
| Ito, N; Kurata, Y; Sakata, T; Shirai, T; Tamano, S; Tsuda, H | 1 |
| Alexandrov, VA; Berstein, LM | 2 |
| Berger, MR; Habs, M; Schmähl, D | 1 |
| Eisenberg, E; Krutchkoff, DJ; Murthy, AS; Vawter, GF | 1 |
| Ohshima, M; Ward, JM | 1 |
| Cravioto, H; Hochgeschwender, U; Hochwald, GM; Kida, Y; Ransohoff, J | 1 |
| Fukushima, S; Imaida, K; Ito, N; Shirai, T; Tatematsu, M; Tsuda, H | 1 |
| Singer, B | 1 |
| Nomura, T | 1 |
| Preussmann, R | 1 |
| Narisawa, T; Sato, M; Takahashi, T; Tani, M | 1 |
| Hudson, EA; Jones, RT; Resau, JH | 1 |
| Barka, T | 1 |
| Kempson, RL; Kirkman, H | 1 |
| Babaya, K; Chmiel, JS; Izumi, K; Miyata, Y; Morikawa, A; Oyasu, R; Ozono, S | 1 |
| Donahoe, R; Reznik, G; Reznik-Schüller, HM; Stinson, SF | 1 |
| Brésil, H; Ivanov, MN; Likhachev, AJ; Margison, GP; Montesano, R; Planche-Martel, G | 1 |
| Babaya, K; Morikawa, A; Oyasu, R; Ozono, S | 1 |
| Blasberg, RG; Fenstermacher, J; Horowitz, M; Molnar, P; Smith, B | 1 |
| Blasberg, RG; Fenstermacher, J; Horowitz, M; Kornblith, P; Molnar, P; Pleasants, R | 1 |
| Asbery, LJ; Chandler, PM; Harris, G; Jones, MG; Lawley, PD | 1 |
| Alekandrov, VA; Anisimov, VN; Bespalov, VG; Korsakov, MV; Likhachev, AJ; Napalkov, NP; Ovsyannikov, AI; Popovich, IG; Tomatis, L | 1 |
| Starling, JR; Turner, JH; Weese, JL | 1 |
| Berger, M; Habs, M; Schmähl, D | 1 |
| Konstantinidis, A; Smulow, JB; Sonnenschein, C | 2 |
| Cohen, BI; Deschner, EE; Fazzini, E; Raicht, RF; Sarwal, AN; Takahashi, M | 1 |
| Frei, JV; Lawley, PD | 1 |
| Becci, PJ; Grubbs, CJ; Moon, RC; Thompson, HJ | 2 |
| Blackwell, BN; Lijinsky, W; Reuber, MD | 1 |
| Berman, JJ; Rice, JM | 1 |
| Donahoe, R; Reznik, G; Stinson, SF | 1 |
| Habs, M; Ivankovic, S; Schmähl, D; Zeller, WJ | 1 |
| Reibel, J | 1 |
| De Bernardo, E | 1 |
| Bonneville, MA; Caruthers, JM | 1 |
| Aleksandrov, VA; Anisimov, VN; Belous, NM; Matson, VB; Vasil'eva, IA | 1 |
| Hicks, RM | 1 |
| Pinsky, SD; Woolley, PV | 1 |
| McCormick, DL; Moon, RC | 1 |
| Chandrasekaran, V; Milmore, JE; Weisburger, JH | 1 |
| Barnes, SH; Hicks, RM; Severs, NJ; Wright, R | 1 |
| Cohen, BI; Deschner, EE; Raicht, RF | 1 |
| Shafer, RH; Wun, KL | 1 |
| Carter, TH; Trombetta, LD; Weisbroth, SH; Zimmerman, JA | 1 |
| Parsa, I | 1 |
| Allhoff, EP; Chapman, CM; Hagen, IK; Lin, CW; Lin, JC; Mei, H; Proppe, KH; Prout, GR | 1 |
| Iversen, OH | 2 |
| Branham, WS; Frederick, CB; Heath, JE; Sheehan, DM | 1 |
| Narisawa, T; Sano, M; Sato, M; Takahashi, T | 1 |
| Henderson, SD; Kimler, BF; Scanlan, MF | 1 |
| Cohen, BI; Fazzini, E; Raicht, RF | 1 |
| Hirota, N; Katayama, S; Reddy, BS | 1 |
| Iversen, OH; Kauffman, SL | 1 |
| Lijinsky, W | 1 |
| Warzok, H; Warzok, R | 1 |
| Althoff, J; Brune, H; Deutsch-Wenzel, R; Green, U; Schneider, P | 1 |
| Goto, A; Kudo, T; Narisawa, T; Sato, M; Takahashi, T; Tani, M | 1 |
| Grossman, HB; Lesser, ML; Sonda, LP | 1 |
| Cockerell, GL; O'Donnell, RW | 1 |
| Cohen, BI; Raicht, RF | 1 |
| Boehm, TL; Drahovsky, D | 1 |
| Babaya, K; Miyata, Y; Oyasu, R | 1 |
| Anders, A; Anders, F; Chatterjee, K; Kollinger, G; Schmidt, CR | 1 |
| Kaufman, DG; Kaufmann, WK; Rice, JM; Wenk, ML | 1 |
| Dean, J; Reznik, G; Ward, JM; Wenk, ML | 1 |
| Katayama, S; Lauber, J; Levenstein, MJ; Musser, TK; Reddy, M; Silverman, J; Weisburger, H; Zelenakas, K | 1 |
| Börzsönyi, M; Pintér, A | 1 |
| Eismann, C; Herbst, C; Mendel, J; Thust, R; Warzok, R | 1 |
| Chan, FP; Ens, B; Frei, JV | 1 |
| Cohadon, F | 1 |
| Humphrey, LJ; Humphrey, M; McCarthy, RP; Volenec, FJ; Whitmore, S | 1 |
| Kohno, KI; Narisawa, T; Takahashi, T; Yamaguchi, T | 1 |
| Cohen, BI; Fazzini, EP; Raicht, RF; Sarwal, AN; Takahashi, M | 1 |
| Cockerell, GL; Kriedemann, WL; O'Donnell, RW; Perez, R | 1 |
| Chowaniec, J; Grasso, P; Hicks, RM; Hooson, J | 1 |
| Müller, HA; Schäffer, R | 2 |
| Anver, MR; Anzano, MA; Brown, CC; Driver, CL; Green, DM; Logsdon, DL; Lucia, MS; Peer, CW; Shrader, MW; Slayter, MV | 1 |
| Akagi, K; Hirose, M; Hoshiya, T; Ito, N; Mizoguchi, Y; Shirai, T | 1 |
| Ioachim, HL; Moroson, H | 1 |
| Dreyfuss, DA; Krizek, TJ; Leoni, KJ; Su, CW | 1 |
| Anisimov, VN; Zhukova, OV | 1 |
| Anver, MR; Lijinsky, W; Moschel, RC; Pegg, AE | 1 |
| Mangues, R; Oliva, MR; Pellicer, A; Saez, GT | 1 |
| Anisimov, VN | 3 |
| Katsuki, M | 1 |
| Fukushima, S; Futakuchi, M; Hirose, M; Ito, N; Takahashi, S; Tanaka, H | 1 |
| Mori, H; Morishita, Y; Sasaki, S; Tanaka, T | 1 |
| Fukushima, S; Kurata, Y; Mizoguchi, M; Montesano, R; Naito, H; Shibata, MA; Tsuda, H; Wild, CP | 1 |
| Asakawa, E; Fukushima, S; Kawabe, M; Sano, M; Shioya, S; Shirai, T; Tamano, S; Tanaka, H | 1 |
| Becker, K; Dosch, J; Gregel, CM; Kaina, B; Martin, BA | 1 |
| Akagi, K; Hasegawa, R; Hirose, M; Kimura, J; Kurata, M; Ogiso, T; Shirai, T; Takahashi, S; Yoshida, Y | 1 |
| Katayama, H; Niimi, S; Skagishi, Y; Sonoda, M; Yano, K | 1 |
| Fukuda, T; Hayashi, Y; Hioki, K; Kodama, Y; Manabe, S; Matsunuma, N; Mitsumori, K; Nomura, G; Nomura, T; Okamiya, H; Sakamaki, Y; Sunaga, M; Suzuki, H; Wakana, S; Yamamoto, S | 1 |
| Mizuoka, H; Shikata, N; Tsubura, A; Yang, J | 1 |
| Anisimov, VN; Buzard, GS; Calvert, RJ; Rice, JM | 1 |
| Inada, K; Masui, T; Miyashita, N; Nakanishi, H; Tatematsu, M; Tezuka, N | 1 |
| Ahn, B; Han, BS; Hasegawa, R; Ito, N; Kim, DJ; Shirai, T; Tsuda, H | 1 |
| Asamoto, M; Hirono, I; Hori, T; Iwahori, Y; Iwase, T; Kim, DJ; Matsumoto, K; Nagao, M; Nishida, Y; Takasuka, N; Tsuda, H; Ushijima, T | 1 |
| Gerhauser, C; Kinghorn, AD; Kosmeder, JW; Moon, RC; Moriarty, RM; Pezzuto, JM; Thomas, CF; Udeani, GO | 1 |
| Allay, E; Gerson, SL; Koç, ON; McGuire, EA; Reese, JS; Sedransk, N | 1 |
| Anisimov, VN; Mikheev, VS; Musatov, SA; Rosenfeld, SV; Togo, EF | 1 |
| Futakuchi, M; Hasegawa, R; Ito, N; Lijinsky, W; Mizoguchi, Y; Shirai, T; Yamaguchi, T | 1 |
| Iwakuma, T; Kawate, H; Tsuzuki, T | 1 |
| Gordon, GB; Grubbs, CJ; Kelloff, GJ; Lei, XD; Lubet, RA; Moon, RD; Prough, RA; Steele, VE; Thomas, CF; Wang, Y; You, M | 1 |
| Ishikawa, T; Kawate, H; Nakatsuru, Y; Noda, T; Sakumi, K; Sekiguchi, M; Takahashi, S; Takano, H; Tsuzuki, T | 1 |
| Cooper, DP; Delker, DA; Papanikolaou, A; Povey, A; Rosenberg, DW; Shank, RC | 1 |
| Griffiths, JR; Lemaire, LP; McSheehy, PM | 1 |
| Bosland, MC | 1 |
| Gill, TJ; Hayashi, T; Hioki, K; Katoh, H; Kawamura, A; Konoeda, Y; Kunz, HW; Natori, T; Nomura, T; Tamaki, T | 1 |
| André, V; Anisimov, VN; Godard, T; Musatov, SA; Sichel, F; Vigreux, C | 1 |
| Fukushima, S; Morii, H; Nishizawa, Y; Otani, S; Salim, EI; Taniyama, T; Wanibuchi, H; Yano, Y | 1 |
| Ide, F; Ishikawa, T; Itoh, R; Kawate, H; Nakabeppu, Y; Nawata, H; Noda, T; Sakumi, K; Sekiguchi, M; Tsuzuki, T | 1 |
| Barbisan, LF; Fávero Salvadori, DM; Kaneno, R; Marchesan Rodrigues, MA; Spinardi-Barbisan, AL; Trindade Moreira, EL; Viana de Camargo, JL | 1 |
| Ganther, HE; Ip, C; Thompson, HJ; Zhu, Z | 1 |
| Heddle, JA; Shima, N; Swiger, RR | 1 |
| Elsässer-Beile, U; Freudenberg, N; Mengs, U; Ruhnau, T; Wetterauer, U | 1 |
| Alexandrov, VA; Anisimov, VN; Belous, NM; Mazon, VB; Vasilyeva, IA | 1 |
| Brtko, J; Macejová, D | 1 |
| Hirano, K; Itoh, F; Kominami, G; Nara, H; Ohno, K; Tasaki, T; Torii, M; Yabuuchi, K | 1 |
| Brtko, J; Dvorcakova, M; Líska, J; Macejová, D; Mostböck, S; Scheiblhofer, S; Szabová, E; Thalhamer, J; Weiss, R; Zórad, S | 1 |
| Bobrov, IuF; Okulov, BV | 1 |
| Borisov, VI | 1 |
| Beniashvili, DSh; Dimant, IN | 2 |
| Gorbacheva, LB; Kukushkina, GV; Sokolova, IS | 1 |
| Frie, JV; Maitra, SC | 1 |
| Abakumova, OY; Gorbachieva, LB; Kutcenko, NG; Lerman, MI; Serebryannyl, AM; Sokolova, IS | 1 |
| Eichberg, J; Hauser, G; Shein, HM | 1 |
| Thust, R | 2 |
| Abkumova, OIu; Kutsenko, NG; Lerman, MI; Serebrianyi, AM; Sokolova, IS | 1 |
| Lerman, MI; Pilipenko, NN; Sokolova, IS; Ugarova, TIu | 1 |
| Adamson, RH; Sieber, SM | 1 |
| Epstein, SS; Iqbal, ZM; Yoshida, A | 1 |
| Milievskaia, IL; Vasil'eva, NN | 1 |
| Bischoff, W; Elsässer, E; Schnitzer, A; Thomas, C | 1 |
| Fomenko, LA; Gaziev, AI; Kulagina, TP; Petrov, SI; Zakrzhevskaia, DT | 1 |
| Swenberg, JA | 2 |
| Miyahara, M; Nakadate, M; Odashima, S; Suzuki, I | 1 |
| Lijinsky, W; Taylor, HW | 1 |
| Cravioto, H; Yoshida, J | 1 |
| Chorpenning, FW; Filppi, JA; Koestner, A; Rheins, MS; Zwilling, BS | 1 |
| Herp, A; Lev, R | 1 |
| Benfield, JR; Cohen, AH; Matsumura, K; Shors, EC | 1 |
| Kritchevsky, D; Reddy, BS; Watanabe, K; Weisburger, JH | 1 |
| Hicks, RM; Hodges, GM; Spacey, GD | 1 |
| Anichkov, NM | 1 |
| Jänisch, W; Scholtze, P; Schreiber, D; Warzok, R | 1 |
| Benda, P; Levy, S; Markovits, P; Nocentini, S; Papadopoulo, D; Tripier, MF | 1 |
| Beniashvili, DSh | 3 |
| Beniashvili, DSh; Liamtsev, VI; Turkiia, NG | 1 |
| Afanas'ev, GG; Pelevina, II | 1 |
| Buecheler, J; Cooper, HK; Diessner, H; Kleihues, P; Kolar, GF | 1 |
| Afanas'ev, GG; Gotlib, VIa; Pelevina, II | 1 |
| Becci, PJ; Thompson, HJ | 1 |
| Coutelle, C | 1 |
| Nettesheim, P; Yarita, T | 2 |
| Becci, PJ; Grubbs, CJ; Moon, RC; Norikane, K; Thompson, HJ | 1 |
| Rao, MS; Reddy, JK | 2 |
| Cox, R; Irving, CC; Murphy, WM | 1 |
| Blümel, G; Stavrou, D; Zänker, KS | 1 |
| Broggini, M; Colombo, T; Donelli, MG; Garattini, S | 1 |
| Furuta, K; Maekawa, A; Nakadate, M; Odashima, S; Ogiu, T | 1 |
| Nettesheim, P; Williams, ML; Yarita, T | 1 |
| Denlinger, RH; Koestner, A; Swenberg, JA | 1 |
| Benfield, JR; Cohen, AH; Jensen, T; Matsumara, K; Okita, M; Shors, E | 1 |
| Dean, RJ; Feeser, D; Smith, JM; Sporn, MB; Ward, JM; Wenk, ML | 1 |
| Aleksandrov, VA; Schreiber, D | 1 |
| Blaufuss, EM; Mendel, J; Schwarz, H; Thust, R; Warzok, R | 1 |
| Abdo, S; Ahuja, MR; Anders, A; Anders, F; Haas, J; Kollinger, G; Schwab, M | 2 |
| Kono, K; Narisawa, T; Takahashi, T; Yamaguchi, T | 1 |
| Anzil, AP; Elling, H; Stavrou, D | 1 |
| Belitskiĭ, GA; Bogush, TA; Shabad, LM | 1 |
| Hirao, Y; Iwasaki, T; Matsumoto, M; Oyasu, R; Tabuchi, Y | 1 |
| Engelmann, U; Kuschnir, H; Schmack, B; Schmidt, H; Waldbaur, H | 1 |
| Anzil, AP; Blizinger, K; Stavrou, D | 1 |
| Reddy, BS; Watanabe, K; Weisburger, JH; Wong, CQ | 1 |
| Frei, JV; Lawley, PD; Swenson, DH; Warren, W | 1 |
| Schabel, FM | 1 |
| Pozharisskiĭ, KM | 1 |
| Martino, C; Soloway, MS | 1 |
| Alexandrov, VA | 1 |
| Kiseleva, NS; Milievskaja, IL | 1 |
| Benfield, JR; Cohen, AH; Jensen, T; Matsumura, K; Okita, M; Shors, E | 1 |
| Brown, CC; Smith, JM; Sporn, MB; Springer, S; Squire, RA; Wenk, ML | 2 |
| Pegg, AE | 1 |
| Bosch, DA | 2 |
| Balish, E; Bryan, GT; Croft, WA; Lower, G; Pamukcu, AM; Shih, CN; Yale, CE | 1 |
| Rupprecht, E; Rupprecnt, U; Schneider, J; Thust, R; Warzok, R | 1 |
| Haas, H; Hilfrich, J; Ketkar, M; Mohr, U; Reznik, G | 1 |
| Chowaniec, J; Hicks, RM | 1 |
| Koestner, A; Koestner, AW; Ruecker, FA | 1 |
| Reddy, BS; Watanabe, K; Weisburger, JH | 1 |
| Amlacher, E; Bierwolf, D | 1 |
| Abakumova, OIu; Kazakova, OV; Lerman, MI; Orekhovich, VN | 1 |
| Cooper, HK; Kleihues, P | 1 |
| Maekawa, A; Odashima, S; Tada, K; Takeuchi, M | 1 |
| Dahme, E; Kalich, J; Stavrou, D | 2 |
| Kmoch, N; Mohr, U; Reznik, G | 1 |
| Balanski, RM; Khudoleĭ, VV; Vlasov, NN | 1 |
| Aleksandrov, VA; Anisimov, VN | 1 |
| Suzuki, M | 1 |
| Palestro, G; Stramignoni, A | 1 |
| Carter, SK; Slavik, M; Wasserman, TH | 1 |
| Soloway, MS; Weldon, TE | 1 |
| Corbett, TH; Griswold, DP; Peckham, JC; Roberts, BJ; Schabel, FM | 1 |
| Bots, GT; Willighagen, RG | 1 |
| Haas, H; Hilfrich, J; Kmoch, N; Mohr, U | 1 |
| Ishida, Y; Kanda, H; Okamoto, K; Tamura, M | 1 |
| Maronpot, R; Narisawa, T; Reddy, BS; Weisburger, JH; Wynder, EL | 1 |
| Denlinger, RH; Koestner, A | 1 |
| Corbett, TH; Griswold, DP | 1 |
| Thust, C; Thust, R | 1 |
| Cabral, JR; Rossi, L; Terracini, B; Testa, MC | 1 |
| Friedman, RD; Reese, DH; Smith, JM; Sporn, MB | 1 |
| Anisimov, VN; Osipova, GIu | 1 |
| Catalano, A; Huang, PH | 1 |
| Kovatch, RM; Lijinsky, W; Thomas, BJ | 1 |
| Aoki, T; Inoue, T; Ito, N; Kagawa, M; Ogiso, T; Tagawa, Y; Tsuda, H; Uwagawa, S | 1 |
| Bae, JH; Cho, KJ; Jang, JJ; Lee, YS | 2 |
| Fukushima, S; Hirose, M; Ito, N; Kato, T; Shibata, MA; Tatematsu, M | 1 |
| Bochert, G; Neubert, D; Platzek, T; Rahm, U | 1 |
| Fukushima, S; Ito, N; Shirai, T | 1 |
| Adlakha, H; Thompson, HJ | 1 |
| Hirose, M; Imaida, K; Ito, N; Takahashi, S; Yamaguchi, S | 1 |
| Dohi, K; Ito, A; Mori, M; Naito, M; Takeichi, N; Watanabe, H | 1 |
| Kokoska, S; Urlwin, J | 1 |
| Anisimov, VN; Iakovleva, TK; Monakhov, AS | 1 |
| Best, KL; Hoover, DM; McKenney, BK; Neubauer, BL; Tamura, RN | 1 |
| Anisimov, VN; Bortkevich, SM | 1 |
| Berger, MR; Betsch, B; Brix, HP; Corr, R; Floride, JA; Schmähl, D | 1 |
| Barbacid, M; Sukumar, S | 1 |
| Bopp, BA; Kesterson, JW; Sonders, RC | 1 |
| Alexandrov, VA; Anisimov, VN; Napalkov, NP; Popovich, IG | 1 |
| Hirose, M; Ito, N; Shibata, M; Shirai, T; Tanaka, H | 1 |
| Ivanov, AS; Konradov, AA; Korman, DB; Ostrovskaia, LA; Rykova, VA | 1 |
| Cooper, CS; Newbold, RF; Shiner, AC | 1 |
| Barbacid, M | 1 |
| Berger, MR; Schmähl, D | 1 |
| Aleksandrov, VA; Anisimov, VN; Popovich, IG | 1 |
| Furuta, K; Kanno, J; Kawazoe, Y; Maekawa, A; Matsushima, Y; Nagaoka, T; Oh-hara, T; Onodera, H; Todate, A | 1 |
| Bogoslovskaia, EP; Fomina, MM; Korman, DB; Osatrovskaia, LA; Potapov, SL | 1 |
| Eydmann, ME; Knowles, MA; Padua, RA; Proctor, A; Roberts, J | 1 |
| Lijinsky, W; Reuber, MD | 1 |
| Schoenig, GP | 1 |
| Mikheev, AM | 1 |
| Ivankovic, S; Kempf, SR | 1 |
| Birt, DF; Bresnick, E; Tibbels, MG; Walker, B | 1 |
| Aleksandrov, VA; Blinova, GA; Napalkov, NP; Popovich, IG | 2 |
| Krutova, TV; Ostrovskaia, LA | 1 |
| Berger, MR; Habs, M; Petru, E; Schmähl, D | 1 |
| Chen, JJ; Gaylor, DW; Kodell, RL | 1 |
| Berger, MR; Bischoff, H; Fritschi, E; Henne, T; Herrmann, M; Pool, BL; Satzinger, G; Schmähl, D; Weiershausen, U | 1 |
| Csiba, A | 1 |
| Dirheimer, G; Pfohl-Leszkowicz, A | 1 |
| Furuta, K; Hayashi, Y; Maekawa, A; Matsuoka, C; Mitsumori, K; Ogiu, T; Onodera, H; Tanigawa, H | 1 |
| Aleksandrov, VA; Bershteĭn, LM | 1 |
| Bücher, T; Kerler, R; Legner, M; Müller, L; Rabes, HM; Rode, G; Schuster, C | 1 |
| Hiraki, S | 2 |
| Abe, H; Allen, N; Clendenon, NR; Swenberg, JA | 1 |
| Harris, CC | 1 |
20 review(s) available for methylnitrosourea and Experimental Neoplasms
| Article | Year |
|---|---|
N-methyl-N-nitrosourea-induced schwannomas in male Sprague-Dawley rats with a literature review of inducible and spontaneous lesions.
Topics: Animals; Carcinogens; Databases, Factual; Male; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Rats, Sprague-Dawley | 2016 |
Alternative mouse models for carcinogenicity assessment: industry use and issues with pathology interpretation.
Topics: Animals; Carcinogenicity Tests; Disease Models, Animal; Genes, ras; Methylnitrosourea; Mice; Neoplasms, Experimental; Terminology as Topic; Tumor Suppressor Protein p53 | 2010 |
A review of in vitro and in vivo culture techniques for the study of pancreatic carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cattle; Cells, Cultured; Cricetinae; Culture Media; Gelatin Sponge, Absorbable; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosamines; Organ Culture Techniques; Pancreatic Ducts; Pancreatic Neoplasms | 1981 |
Luminal plasma membrane alterations in bladder cancer.
Topics: Animals; Cell Membrane; Cell Membrane Permeability; Cilia; FANFT; Intercellular Junctions; Methylnitrosourea; Microvilli; Neoplasms, Experimental; Rats; Saccharin; Urinary Bladder; Urinary Bladder Neoplasms | 1980 |
Multistage carcinogenesis in the urinary bladder.
Topics: Animals; Cricetinae; Cyclamates; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Female; Formamides; Methylnitrosourea; Neoplasms, Experimental; Rats; Saccharin; Skin Neoplasms; Urinary Bladder Calculi; Urinary Bladder Neoplasms | 1980 |
[Development of animal models for carcinogenesis by transgenesis. Transgenic mouse models for cancer research].
Topics: Animals; Disease Models, Animal; Genes, ras; Humans; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasms, Experimental; Transduction, Genetic | 1993 |
[Study on carcinogenesis and mutation suppression: repair of alkylation DNA damage and suppression of tumors].
Topics: Alkylation; Animals; DNA Damage; DNA Repair; Gene Targeting; Humans; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mutagens; Mutation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Trimethylsilyl Compounds | 1998 |
Use of animal models in defining efficacy of chemoprevention agents against prostate cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma in Situ; Disease Models, Animal; Humans; Male; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasms, Experimental; Prostatic Neoplasms; Rats; Sensitivity and Specificity; Treatment Outcome | 1999 |
Chemically induced carcinogenesis: a comparison of 1-methyl-1-nitrosourea, 7,12-dimethylbenzanthracene,diethylnitroso-amine and azoxymethan models (minireview).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Azoxymethane; Carcinogens; Diethylnitrosamine; Methylnitrosourea; Neoplasms, Experimental | 2001 |
Soviet antitumor preparations.
Topics: Animals; Antineoplastic Agents; Aziridines; Butylated Hydroxytoluene; Dactinomycin; Daunorubicin; Humans; Melphalan; Methylnitrosourea; Neoplasms, Experimental; Nitrogen Mustard Compounds; Olivomycins; Organophosphorus Compounds; Phenylalanine; Prospidium; Pyrimidines; Spiro Compounds; Streptonigrin; Tegafur; Triethylenephosphoramide; Uracil | 1977 |
Chemical- and virus-induced brain tumors.
Topics: Adenoviridae; Alkylation; Alpharetrovirus; Animals; Brain Neoplasms; Carcinogens; Disease Models, Animal; DNA, Neoplasm; Ethylnitrosourea; Humans; Methylnitrosourea; Neoplasms, Experimental; Oncogenic Viruses; Papillomaviridae; Polycyclic Compounds; Polyomaviridae; Retroviridae; Tumor Virus Infections | 1977 |
Epithelial-stromal interactions in normal and chemical carcinogen-treated adult bladder.
Topics: Animals; Cell Differentiation; Cell Membrane; Culture Techniques; Epithelium; Female; Mesoderm; Methylnitrosourea; Microscopy, Electron, Scanning; Microvilli; Neoplasms, Experimental; Precancerous Conditions; Rats; Urinary Bladder; Urinary Bladder Neoplasms | 1977 |
[Experimental replication of bladder tumors. Morphologic features of early stages of their development].
Topics: 2-Acetylaminofluorene; 2-Naphthylamine; Animals; Butylhydroxybutylnitrosamine; Cell Membrane; Cell Transformation, Neoplastic; DNA, Neoplasm; Epithelium; FANFT; Humans; Hyperplasia; Methylcholanthrene; Methylnitrosourea; Mice; Microscopy, Electron; Naphthalenes; Neoplasms, Experimental; Papilloma; Rats; Schistosoma haematobium; Species Specificity; Sulfonamides; Urinary Bladder Neoplasms | 1979 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Combination; Leukemia L1210; Lomustine; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Semustine | 1976 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyrenes; Brain Neoplasms; Carcinogens; Cricetinae; Dimethylhydrazines; Dogs; Esophageal Neoplasms; Ethionine; Ethylnitrosourea; Female; Hematopoietic System; Intestinal Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Nitrosoguanidines; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Precancerous Conditions; Rats; Skin Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms | 1975 |
Clinical comparison of the nitrosoureas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carmustine; Chemical Phenomena; Chemistry; Colonic Neoplasms; Drug Therapy, Combination; Hodgkin Disease; Humans; Lomustine; Lung Neoplasms; Lymphoma; Melanoma; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Rectal Neoplasms | 1975 |
Toxicological aspects of cyclamate and cyclohexylamine.
Topics: Abnormalities, Drug-Induced; Absorption; Adrenal Glands; Animals; Bacteria; Blood; Blood Glucose; Chick Embryo; Chromosome Aberrations; Cocarcinogenesis; Cricetinae; Cyclamates; Cyclohexylamines; Digestive System; Female; Germ Cells; Heart; Humans; In Vitro Techniques; Intestines; Kidney; Lethal Dose 50; Liver; Liver Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Macaca mulatta; Male; Methylnitrosourea; Mice; Mutagenicity Tests; Mutagens; Mutation; Neoplasms, Experimental; Pancreas; Pregnancy; Rabbits; Rats; Rats, Inbred Strains; Reproduction; Sympathomimetics; Testis; Thyroid Gland; Tissue Distribution; Urinary Bladder Neoplasms | 1986 |
Fetal macrosomia and sex differences in the influence of modifying factors on transplacental carcinogenesis.
Topics: Animals; Female; Fetal Macrosomia; Glucose; Male; Methylnitrosourea; Neoplasms, Experimental; Pregnancy; Prenatal Exposure Delayed Effects; Sex Factors | 1989 |
Oncogenes and human cancer: cause or consequence?
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Chromosome Mapping; Gene Expression Regulation; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasms; Neoplasms, Experimental; Oncogenes; Proto-Oncogenes; Rats; Retroviridae; Skin Neoplasms | 1986 |
Cause and prevention of lung cancer.
Topics: Animals; Asbestos; Benzopyrenes; Cricetinae; Disease Models, Animal; Humans; Lung Neoplasms; Methylnitrosourea; Neoplasms; Neoplasms, Experimental; Orthomyxoviridae; Smoking; Vitamin A | 1974 |
1 trial(s) available for methylnitrosourea and Experimental Neoplasms
| Article | Year |
|---|---|
Urothelial susceptibility to tumor cell implantation: comparison of cauterization with N-methyl-N-nitrosourea.
Topics: Animals; Carcinoma, Transitional Cell; Cautery; Clinical Trials as Topic; Epithelium; Female; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Random Allocation; Urinary Bladder; Urinary Bladder Neoplasms | 1983 |
299 other study(ies) available for methylnitrosourea and Experimental Neoplasms
| Article | Year |
|---|---|
Protocol for chemically induced murine gastric tumor model.
Topics: Animals; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Stomach; Stomach Neoplasms | 2021 |
Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.
Topics: Adenocarcinoma; Animals; Barrett Esophagus; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Environmental Exposure; Esophageal Neoplasms; Humans; Methylnitrosourea; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; Neoplasms, Experimental; Organoids; Precancerous Conditions; Stomach Neoplasms; Tumor Suppressor Protein p53 | 2020 |
PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice.
Topics: Administration, Oral; Animals; Carcinogenesis; Gastric Mucosa; Gastrins; Helicobacter felis; Helicobacter Infections; Humans; Immune Checkpoint Inhibitors; Methylnitrosourea; Mice; Mice, Knockout; Myeloid-Derived Suppressor Cells; Neoplasms, Experimental; Programmed Cell Death 1 Receptor; Signal Transduction; Stomach Neoplasms; Tumor Microenvironment | 2021 |
Sesquiterpenoid bilobalide inhibits gastric carcinoma cell growth and induces apoptosis both in vitro and in vivo models.
Topics: Animals; Apoptosis; Bilobalides; Cell Line, Tumor; Cell Proliferation; Ginkgo biloba; Humans; Male; Methylnitrosourea; Neoplasms, Experimental; Plant Extracts; Rats; Rats, Wistar; Stomach Neoplasms | 2021 |
Palliative Role of Aqueous Ginger Extract on
Topics: Alkylating Agents; Animals; Disease Models, Animal; Glutathione Peroxidase; Humans; Lipid Peroxidation; Male; Methylnitrosourea; Neoplasms, Experimental; Oxidative Stress; Palliative Care; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Stomach Neoplasms; Zingiber officinale | 2020 |
Bone marrow mesenchymal stem cells participate in prostate carcinogenesis and promote growth of prostate cancer by cell fusion in vivo.
Topics: Animals; Antigens, Ly; Carcinogenesis; Cell Fusion; Disease Progression; Leukocyte Common Antigens; Male; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, SCID; Mice, Transgenic; Neoplasms, Experimental; Prostate; Prostatic Neoplasms; Tumor Microenvironment | 2016 |
IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice.
Topics: Adenosine Triphosphate; Animals; Bronchoalveolar Lavage Fluid; Calpain; Carcinogenesis; Caspase 1; Caspase Inhibitors; Caspases; Caspases, Initiator; Cells, Cultured; Clodronic Acid; Dipeptides; Female; Glyburide; Inflammasomes; Interleukin-1alpha; Interleukin-1beta; Lipopolysaccharides; Lung Neoplasms; Macrophages, Alveolar; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Experimental; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Specific Pathogen-Free Organisms; Toll-Like Receptor 4 | 2016 |
Carcinogenic comparative study on rasH2 mice produced by two breeding facilities.
Topics: Animals; Breeding; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Female; Genes, ras; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 2008 |
[Establishment of an animal model with thymic lymphoma in mice].
Topics: Animals; Female; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Thymus Neoplasms; Trimethylsilyl Compounds | 2009 |
[Improvement of mouse model for thymic lymphoma induced by N-methyl-N-nitrosourea].
Topics: Animals; Female; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Thymus Neoplasms | 2010 |
Experimental gastric carcinogenesis in Cebus apella nonhuman primates.
Topics: Animals; Cebus; Cell Line; Crotalid Venoms; Disease Models, Animal; Gene Dosage; Gene Expression Regulation, Neoplastic; Immunohistochemistry; In Situ Hybridization, Fluorescence; Methylnitrosourea; Neoplasms, Experimental; Plant Extracts; Proto-Oncogene Proteins c-myc; RNA, Messenger; Stomach Neoplasms; Ultrasonography | 2011 |
Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging.
Topics: Alkylating Agents; Animals; Blotting, Southern; Carcinogenicity Tests; Female; Genes, ras; Humans; Hypoxia-Inducible Factor 1; Image Processing, Computer-Assisted; Ischemia; Luminescent Measurements; Luminescent Proteins; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental; Papilloma; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2011 |
Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats.
Topics: Adenocarcinoma; Administration, Oral; Alkylating Agents; Animals; Colonic Neoplasms; Female; Honey; Malondialdehyde; Methylnitrosourea; Neoplasms, Experimental; Nigella sativa; Nitric Oxide; Oxidative Stress; Phytotherapy; Rats; Rats, Sprague-Dawley | 2002 |
Effects of weaning by surrogate mothers (ACI) on tumor development in SD rats treated with methylnitrosourea (MNU) and/or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Topics: Animals; Animals, Suckling; Carcinogens; Female; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Milk; Neoplasms, Experimental; Rats; Rats, Inbred ACI; Rats, Sprague-Dawley; Species Specificity | 2002 |
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Cacao; Carcinoma; Catechin; Diethylnitrosamine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Flavonoids; Gastrointestinal Neoplasms; Injections, Intraperitoneal; Injections, Subcutaneous; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Phenols; Phytotherapy; Pituitary Neoplasms; Plant Extracts; Polymers; Proanthocyanidins; Rats; Rats, Inbred F344; Thyroid Neoplasms; Urogenital Neoplasms | 2003 |
Variable E-cadherin expression in a MNU-induced colon tumor model in rats which exposed with 50 Hz frequency sinusoidal magnetic field.
Topics: Animals; Cadherins; Colon; Colonic Neoplasms; Disease Models, Animal; Electromagnetic Fields; Immunoenzyme Techniques; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Wistar | 2002 |
Effect of 2-methoxyestradiol on the growth of methyl-nitroso-urea (MNU)-induced rat mammary carcinoma.
Topics: 2-Methoxyestradiol; Animals; Carcinogens; Estradiol; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
Activity, pharmacokinetics and tissue distribution of TLC ELL-12 (liposomal antitumor ether lipid) in rats with transplantable, s.c. methylnitrosourea-induced tumors.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Area Under Curve; Female; Half-Life; Injections, Intravenous; Liposomes; Metabolic Clearance Rate; Methylnitrosourea; Neoplasms, Experimental; Phospholipid Ethers; Rats; Tissue Distribution | 2003 |
[INDUCTION OF CANCER BY A SINGLE DOSE OF METHYLNITROSO-UREA AND VARIOUS DIALKYLNITROSAMINES IN RATS].
Topics: Brain Neoplasms; Carcinogens; Esophageal Neoplasms; Female; Humans; Kidney Neoplasms; Liver Neoplasms; Methylnitrosourea; Neoplasms; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Ovarian Neoplasms; Paranasal Sinus Neoplasms; Rats; Research; Sarcoma; Sarcoma, Experimental; Toxicology | 1964 |
[SELECTIVE INDUCTION OF MALIGNANT TUMORS IN THE BRAIN AND SPINAL CORD OF RATS BY N-METHYL-N-NITROSOUREA].
Topics: Brain; Brain Neoplasms; DNA; DNA, Neoplasm; Methylnitrosourea; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Nitroso Compounds; Organ Specificity; Research; RNA; RNA, Neoplasm; Spinal Cord Neoplasms; Toxicology | 1965 |
Effects of Seocalcitol (EB1089) on nitrosomethyl urea-induced rat mammary tumors.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Calcitriol; Dose-Response Relationship, Drug; Female; Hypercalcemia; Mammary Neoplasms, Animal; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Wistar | 2003 |
Telomere dysfunction results in enhanced organismal sensitivity to the alkylating agent N-methyl-N-nitrosourea.
Topics: Alkylating Agents; Animals; Female; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Experimental; Telomerase; Telomere | 2003 |
Deficient MGMT and proficient hMLH1 expression renders gallbladder carcinoma cells sensitive to alkylating agents through G2-M cell cycle arrest.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Alkylating; Carrier Proteins; Cell Division; Cell Line, Tumor; Dacarbazine; Female; Flow Cytometry; G2 Phase; Gallbladder Neoplasms; Humans; Methylnitrosourea; Mice; Mice, Inbred BALB C; MutL Protein Homolog 1; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger | 2005 |
Modulation of N-methyl-N-nitrosourea induced mammary tumors in Sprague-Dawley rats by combination of lysine, proline, arginine, ascorbic acid and green tea extract.
Topics: Alkylating Agents; Animal Feed; Animals; Antioxidants; Arginine; Ascorbic Acid; Chemoprevention; Female; Injections, Intraperitoneal; Lysine; Mammary Neoplasms, Animal; Methylnitrosourea; Neoplasms, Experimental; Proline; Rats; Rats, Sprague-Dawley; Tea | 2005 |
Use of IC tags in short-term carcinogenicity study on CB6F1 TGrasH2 mice.
Topics: Acetone; Animal Identification Systems; Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Female; Genes, ras; Male; Materials Testing; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasms, Experimental; Tetradecanoylphorbol Acetate | 2006 |
[Antigenicity of a chemically induced neurogenic rat sarcoma (author's transl)].
Topics: Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Cells, Cultured; Cytotoxicity Tests, Immunologic; Epitopes; Immunization; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neurofibroma; Rats; Transplantation, Autologous | 1980 |
Chemical modification and antigenicity of glioma cells.
Topics: Animals; Antibodies, Neoplasm; Antibody Formation; Antigens, Neoplasm; Brain Neoplasms; Epitopes; Female; Glioma; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrobenzenes; Rats; Rats, Inbred F344; Trinitrobenzenesulfonic Acid | 1981 |
Neoplastic lesions in the urinary tract of Wistar rats after treatment with N-methyl-N-nitrosourea (MNU) and artificial sweeteners.
Topics: Animals; Calcium Carbonate; Cyclamates; Drug Synergism; Female; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Saccharin; Sweetening Agents; Urinary Tract; Urologic Neoplasms | 1981 |
[Cyclophosphamide, bleomycin and 1-methyl-1-nitroso-urea (MNU) chemotherapy of experimentally induced carcinoma of the esophagus in BD rats].
Topics: Animals; Bleomycin; Cyclophosphamide; Drug Therapy, Combination; Esophageal Neoplasms; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1983 |
Adenocarcinomas of the prostate induced by N-nitroso-N-methylurea in rats pretreated with cyproterone acetate and testosterone.
Topics: Adenocarcinoma; Animals; Carcinoma in Situ; Cocarcinogenesis; Cyproterone; Cyproterone Acetate; Male; Methylnitrosourea; Models, Biological; Neoplasm Metastasis; Neoplasms, Experimental; Nitrosourea Compounds; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Testosterone | 1983 |
Definition of a cell clone with astroglial characteristics derived from a chemically induced rabbit brain glioma.
Topics: Animals; Brain Neoplasms; Bucladesine; Clone Cells; Fluorescent Antibody Technique; Glioma; Methylnitrosourea; Microscopy, Electron; Microscopy, Electron, Scanning; Neoplasms, Experimental; Nerve Tissue Proteins; Rabbits; S100 Proteins | 1980 |
[Tumour induction with alkyl-nitrosoureas in ribbed newts (Pleurodeles waltlii) (author's transl)].
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Fibrosarcoma; Hemangioma; Hemangiosarcoma; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pleurodeles; Salamandridae; Sarcoma, Experimental; Wilms Tumor | 1980 |
Nephroblastoma and renal mesenchymal tumor induced in rats by N-nitrosoethyl- and N-nitrosomethylurea.
Topics: Animals; Ethylnitrosourea; Female; Kidney Neoplasms; Mesenchymoma; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Wilms Tumor | 1980 |
A clinically relevant canine lung cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Delayed-Action Preparations; Disease Models, Animal; Dogs; Lung Neoplasms; Methods; Methylcholanthrene; Methylnitrosourea; Neoplasms, Experimental; Radioisotopes; Tetradecanoylphorbol Acetate | 1981 |
Endogenous MuLV infection does not contribute to onset of radiation- or carcinogen-induced murine thymoma.
Topics: Alleles; Animals; Carcinogens; Crosses, Genetic; Leukemia Virus, Murine; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Thymoma; Thymus Neoplasms | 1982 |
Cytochemical markers of bladder carcinogenesis.
Topics: 5'-Nucleotidase; 9,10-Dimethyl-1,2-benzanthracene; Alkaline Phosphatase; Animals; Cell Membrane; Cell Transformation, Neoplastic; Female; Methylnitrosourea; Mice; Mice, Inbred C57BL; Microscopy, Electron; Neoplasms, Experimental; Nucleotidases; Organ Culture Techniques; Rats; Rats, Inbred Strains; Urinary Bladder; Urinary Bladder Neoplasms | 1981 |
Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol.
Topics: Animals; Antioxidants; Cocarcinogenesis; Ethinyl Estradiol; Male; Methylnitrosourea; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred F344 | 1984 |
Glucose consumption, newborn weight and nitrosomethylurea transplacental carcinogenesis in rats.
Topics: Animals; Animals, Newborn; Drug Interactions; Female; Fetus; Glucose; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats | 1984 |
[Experimental toxicologic and therapeutic studies on the activity of the CMF(cyclophosphamide-methotrexate-5-fluorouracil) scheme versus the VMF(vincristine-methotrexate-5-fluorouracil) scheme].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma 256, Walker; Cyclophosphamide; Female; Fluorouracil; Male; Mammary Neoplasms, Experimental; Methotrexate; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Vincristine | 1984 |
Odontogenic neoplasms in Wistar rats treated with N-methylnitrosourea.
Topics: Animals; Female; Jaw Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Odontogenic Tumors; Rats; Rats, Inbred Strains | 1983 |
Promotion of N-methyl-N-nitrosourea-induced thyroid tumors by iodine deficiency in F344/NCr rats.
Topics: Animals; Body Weight; Iodine; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Organ Size; Rats; Rats, Inbred Strains; Thyroid Gland; Thyroid Neoplasms | 1984 |
Immunity to transplantable nitrosourea-induced neurogenic tumors. II. Immunoprophylaxis of tumors of the brain.
Topics: Animals; Brain Neoplasms; Corynebacterium; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neurilemmoma; Rats; Rats, Inbred Strains; T-Lymphocytes, Cytotoxic; Transplantation, Isogeneic | 1983 |
Modification of chemical carcinogenesis by antioxidants.
Topics: Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Ethoxyquin; Kidney Neoplasms; Liver Neoplasms; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Stomach Neoplasms; Urinary Bladder Neoplasms | 1983 |
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Guanine; Methylnitrosourea; Neoplasms, Experimental | 1984 |
Timing of chemically induced neoplasia in mice revealed by the antineoplastic action of caffeine.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; DNA Repair; Ethylnitrosourea; Female; Hydroxamic Acids; Lung Neoplasms; Maternal-Fetal Exchange; Methylnitrosourea; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Nitroquinolines; Pregnancy; Time Factors; Urethane | 1980 |
The problem of thresholds in chemical carcinogenesis some views on theoretical and practical aspects.
Topics: Animals; Benzopyrenes; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Tolerance; Methylnitrosourea; Mice; Neoplasms, Experimental; p-Dimethylaminoazobenzene; Rats | 1980 |
Chemoprevention of development of colonic adenomatosis and carcinomatosis with 5-fluorouracil and ftorafur on animal model.
Topics: Adenoma; Animals; Carcinoma; Colon; Colonic Neoplasms; Female; Fluorouracil; Methylnitrosourea; Neoplasms, Experimental; Rats; Tegafur | 1980 |
Effects of isoproterenol on mammary gland tumors induced by N-nitroso-N-methylurea and salivary gland tumors induced by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Female; Isoproterenol; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Salivary Gland Neoplasms | 1982 |
Tumours of the female genitalia.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Diethylstilbestrol; Female; Genital Neoplasms, Female; Humans; Mesocricetus; Methylnitrosourea; Neoplasm Metastasis; Neoplasms, Experimental; Nitrosourea Compounds; Ovarian Neoplasms; Testosterone; Uterine Neoplasms | 1982 |
Capability of urinary components to enhance ornithine decarboxylase activity and promote urothelial tumorigenicity.
Topics: Animals; Carboxy-Lyases; Carcinoma, Squamous Cell; Cell Line; Enzyme Induction; Female; Kinetics; Male; Methylnitrosourea; Neoplasms, Experimental; Ornithine Decarboxylase; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms; Urine | 1983 |
Spindle cell carcinoma of the hamster trachea induced by N-methyl-N-nitrosourea.
Topics: Animals; Carcinoma; Cricetinae; Laryngeal Neoplasms; Male; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Tracheal Neoplasms | 1983 |
Carcinogenicity of single doses of N-nitroso-N-methylurea and N-nitroso-N-ethylurea in Syrian golden hamsters and the persistence of alkylated purines in the DNA of various tissues.
Topics: Alkylation; Animals; Carbon Radioisotopes; Cricetinae; DNA; Ethylnitrosourea; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds | 1983 |
A minimal dose of N-methyl-N-nitrosourea carcinogenic to heterotopically transplanted rat urinary bladder.
Topics: Animals; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms; Urine | 1983 |
Regional blood-to-tissue transport in RT-9 brain tumors.
Topics: Aminoisobutyric Acids; Animals; Autoradiography; Biological Transport; Blood-Brain Barrier; Brain Neoplasms; Choroid Plexus; Hippocampus; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Subarachnoid Space; Tissue Distribution | 1983 |
Regional blood flow in RT-9 brain tumors.
Topics: Animals; Autoradiography; Brain Neoplasms; Cerebrovascular Circulation; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Regional Blood Flow | 1983 |
Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen.
Topics: Anemia, Hemolytic, Autoimmune; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Species Specificity; Spleen; Thymoma; Thymus Neoplasms | 1983 |
Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.
Topics: Adenine; Animals; Brain; DNA; Female; Fetus; Guanine; Kidney; Liver; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Placenta; Pregnancy; Purines; Rats; Time Factors | 1983 |
Development of a carcinogen-induced rat colon cancer with lymph-node metastases.
Topics: Animals; Colonic Neoplasms; Injections; Lymphatic Metastasis; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Rectum | 1983 |
Noncarcinogenic chemotherapy with a combination of vincristine, methotrexate and 5-fluorouracil (VMF) in rats.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Fluorouracil; Male; Mammary Neoplasms, Experimental; Methotrexate; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Time Factors; Vincristine | 1983 |
Age-dependent odontogenic lesions in rats after a single i.p. injection of N-nitroso-N-methylurea.
Topics: Animals; Dentin; Incisor; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Odontogenic Tumors; Odontoma; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Effect of cholic acid feeding on N-methyl-N-nitrosourea-induced colon tumors and cell kinetics in rats.
Topics: Animals; Bile Acids and Salts; Cell Division; Cholic Acids; Cocarcinogenesis; Colon; Colonic Neoplasms; DNA; Kinetics; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Sterols | 1980 |
Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response.
Topics: Alkylating Agents; Animals; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Kinetics; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Rats; Thymoma; Thymus Neoplasms | 1980 |
Histogenesis and dose dependence of N-methyl-N-nitrosourea-induced carcinoma in a localized area of the hamster trachea.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Male; Mesocricetus; Methylnitrosourea; Mucous Membrane; Neoplasms, Experimental; Nitrosourea Compounds; Time Factors; Tracheal Neoplasms | 1980 |
Carcinogenicity of nitrosotrialkylureas in Fischer 344 rats.
Topics: Animals; Astrocytoma; Brain Neoplasms; Carcinogens; Diet; Dose-Response Relationship, Drug; Female; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Spinal Cord Neoplasms; Stomach Neoplasms | 1980 |
Odontogenic tumours produced in Fischer rats by a single intraportal injection of methylnitrosourea.
Topics: Ameloblastoma; Animals; Hepatectomy; Jaw Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Odontogenic Tumors; Odontoma; Rats; Rats, Inbred F344 | 1980 |
Carcinogenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea when applied to a localized area of the hamster trachea.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylnitrosourea; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Trachea; Tracheal Neoplasms | 1981 |
Effect of three retinoids on tracheal carcinogenesis with N-methyl-N-nitrosourea in hamsters.
Topics: Amyloidosis; Animals; Carcinoma; Cricetinae; Isotretinoin; Male; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Precancerous Conditions; Probability; Tracheal Neoplasms; Tretinoin | 1981 |
Experimental chemical production of brain tumors.
Topics: Animals; Brain Neoplasms; Carmustine; Ethylnitrosourea; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1982 |
Carcinogenesis in forestomach and changes in oral mucosa of rats induced by intragastric N-methylnitrosourea.
Topics: Animals; Methylnitrosourea; Mouth Neoplasms; Neoplasms, Experimental; Nitrosourea Compounds; Precancerous Conditions; Rats; Rats, Inbred Strains; Stomach Neoplasms; Time Factors | 1982 |
Natural cytotoxicity against chemically induced neurogenic rat tumors.
Topics: Age Factors; Animals; Brain Neoplasms; Cell Division; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Ethylnitrosourea; Female; Glioma; Immunity, Innate; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Neurilemmoma; Rats; Spleen; T-Lymphocytes | 1982 |
[Inhibition of the transplacental blastomogenic effect of N-nitrosomethylurea in rats by buformin].
Topics: Animals; Antineoplastic Agents; Biguanides; Blood Glucose; Buformin; Castration; Cholesterol; Female; Insulin; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats; Somatomedins; Triglycerides | 1980 |
Binding of N-nitroso carcinogens in pancreatic tissue.
Topics: Animals; Binding Sites; Chromatin; DNA; Guinea Pigs; Islets of Langerhans; Methylnitronitrosoguanidine; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Organoids; Pancreatic Neoplasms; Tissue Distribution | 1981 |
Inhibition of chemical carcinogenesis by retinoids.
Topics: Animals; Castration; Esophageal Neoplasms; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Rats; Vitamin A | 1982 |
Effects of hypothyroidism on development of nitrosomethylurea-induced tumors of the mammary gland, thyroid gland, and other tissues.
Topics: Animals; Female; Hypothyroidism; Kidney Neoplasms; Lung Neoplasms; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Thyroid Neoplasms; Thyroxine; Triiodothyronine | 1982 |
Induction of bladder cancer in rats by fractionated intravesicular doses of N-methyl-N-nitrosourea.
Topics: Animals; Carcinoma in Situ; Carcinoma, Transitional Cell; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Hyperplasia; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Precancerous Conditions; Rats; Rats, Inbred Strains; Urinary Bladder; Urinary Bladder Calculi; Urinary Bladder Neoplasms | 1982 |
The kinetics of the protective effect of beta-sitosterol against MNU-induced colonic neoplasia.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; DNA; Kinetics; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Sitosterols | 1982 |
Structural changes in mammalian cell DNA induced by low-dose x-ray damage and subsequent postirradiation incubation in the presence and absence of caffeine.
Topics: Animals; Brain Neoplasms; Caffeine; Cell Line; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Radiation; In Vitro Techniques; Methylnitrosourea; Neoplasms, Experimental; Rats | 1982 |
Tumorigenesis at a predetermined oral site after one intraperitoneal injection of N-nitroso-N-methylurea.
Topics: Animals; Cell Division; Cocarcinogenesis; Injections, Intraperitoneal; Irritants; Male; Methylnitrosourea; Mouth Neoplasms; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1982 |
Pancreatic carcinoma induced by N-methyl-N'-nitrosourea in aged mice.
Topics: Age Factors; Animals; Carcinoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Microscopy, Electron; Neoplasms, Experimental; Nitrosourea Compounds; Pancreas; Pancreatic Neoplasms | 1982 |
Identification of human acinar cell carcinoma by monoclonal antibody and in vitro differentiation.
Topics: Adult; Animals; Antibodies, Monoclonal; Antigens, Surface; Carcinoma; Cell Membrane; Humans; Methylnitrosourea; Mice; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Neoplasms, Experimental; Organ Culture Techniques; Pancreatic Neoplasms | 1982 |
Rat bladder isograft model for focal carcinoma.
Topics: Animals; Carcinoma, Transitional Cell; FANFT; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Thiazoles; Transplantation, Isogeneic; Urinary Bladder Neoplasms | 1982 |
Enhancement of methylnitrosourea skin carcinogenesis by inhibiting cell proliferation with hydroxyurea or skin extracts.
Topics: Animals; Cell Division; DNA; Female; Hydroxyurea; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Skin; Skin Neoplasms; Tissue Extracts; Tritium | 1982 |
Hydroxyurea enhances methylnitrosourea skin tumorigenesis when given shortly before, but not after, the carcinogen.
Topics: Animals; DNA; Hydroxyurea; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Skin Neoplasms | 1982 |
Evidence for estradiol promotion of neoplastic lesions in the rat vagina after initiation with N-methyl-N-nitrosourea.
Topics: Animals; Castration; Estradiol; Female; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Uterus; Vaginal Neoplasms | 1982 |
Inhibition of development of methylnitrosourea-induced rat colonic tumors by peroral administration of indomethacin.
Topics: Animals; Colonic Neoplasms; Female; Indomethacin; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1982 |
Interaction of hyperthermia and radiation on the survival of synchronous 9L cells.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Survival; Hot Temperature; Methylnitrosourea; Neoplasms, Experimental; Radiotherapy Dosage; Rats | 1982 |
Reduction of N-methyl-N-nitrosourea-induced colon tumors in the rat by cholesterol.
Topics: Animals; Cholesterol, Dietary; Colonic Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344 | 1982 |
Effect of dietary sodium ascorbate on 1,2-dimethylhydrazine- or methylnitrosourea-induced colon carcinogenesis in rats.
Topics: 1,2-Dimethylhydrazine; Animals; Ascorbic Acid; Colonic Neoplasms; Diet; Dimethylhydrazines; Female; Methylhydrazines; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1982 |
Circadian variation in the susceptibility of mouse epidermis to chemical carcinogens.
Topics: Animals; Circadian Rhythm; Methylnitrosourea; Mice; Neoplasms, Experimental; Skin Neoplasms; Statistics as Topic | 1982 |
Comparison of the carcinogenic effectiveness in mouse skin of methyl- and ethylnitrosourea, nitrosourethane and nitrosonitro-guanidine and the effect of deuterium labeling.
Topics: Administration, Topical; Alkylating Agents; Animals; Deuterium; Ethylnitrosourea; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitroso Compounds; Nitrosoguanidines; Nitrosomethylurethane; Skin Neoplasms | 1982 |
The influence of hypoxia on the induction of experimental brain tumors in rats.
Topics: Animals; Brain Neoplasms; Cocarcinogenesis; Hypoxia, Brain; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1982 |
Syncarcinogenic action of saccharin or sodium cyclamate in the induction of bladder tumours in MNU-pretreated rats.
Topics: Animals; Body Weight; Carcinogens; Cyclamates; Drug Synergism; Eating; Female; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Saccharin; Urinary Bladder Neoplasms; Urologic Neoplasms | 1980 |
Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Indomethacin; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1981 |
The effect of single dose N-methyl-N-nitrosourea on bladder carcinogenesis by N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide in rats.
Topics: Animals; Body Weight; Carcinoma, Papillary; Carcinoma, Transitional Cell; FANFT; Female; Hyperplasia; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Organ Size; Rats; Thiazoles; Urinary Bladder; Urinary Bladder Neoplasms | 1981 |
Establishment and biological properties of a guinea pig colonic adenocarcinoma cell line induced by N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Aneuploidy; Animals; Cell Count; Cell Line; Chromosomes; Colonic Neoplasms; Desmosomes; Female; Guinea Pigs; Methylnitrosourea; Mice; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Time Factors | 1981 |
Effects of bile acids on colon carcinogenesis in rats treated with carcinogens.
Topics: Animals; Chenodeoxycholic Acid; Cholic Acids; Cocarcinogenesis; Colonic Neoplasms; Diet; Feces; Methods; Methylnitrosourea; Neoplasms, Experimental; Rats; Steroids | 1981 |
Hypomethylation of DNA in Raji cells after treatment with N-methyl-N-nitrosourea.
Topics: Burkitt Lymphoma; Cell Division; Cell Line; DNA; Humans; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds | 1981 |
Carcinogenesis in heterotopically-transplanted urinary bladder by N-methyl-N-nitrosourea: a model for initiation and promotion.
Topics: Animals; Carcinogens; Disease Models, Animal; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Transplantation, Homologous; Urinary Bladder Neoplasms; Urine | 1981 |
Cytogenetics of neoplasia of Xiphophorus.
Topics: Animals; Chromosome Aberrations; Crosses, Genetic; Fish Diseases; Fishes; Genes, Regulator; Karyotyping; Melanoma; Metaphase; Methylnitrosourea; Neoplasms, Experimental | 1981 |
Reversible inhibition of rat hepatocyte proliferation by hydrocortisone and its effect on cell cycle-dependent hepatocarcinogenesis by N-methyl-N-nitrosourea.
Topics: Animals; Cell Division; Hepatectomy; Hydrocortisone; Kinetics; Liver; Liver Neoplasms; Male; Methylnitrosourea; Mitotic Index; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344 | 1981 |
Effects of three retinoids on colon adenocarcinomas, sarcomas and hyperplastic polyps induced by intrarectal N-methyl-N-nitrosourea administration in male F344 rats.
Topics: Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Hyperplasia; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Sarcoma, Experimental; Suppositories; Vitamin A | 1981 |
Effect of retinoids on the induction of colon cancer in F344 rats by N-methyl-N-nitrosourea or by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Drug Interactions; Endoscopy; Male; Methylhydrazines; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Time Factors; Vitamin A | 1981 |
RNA oncovirus expression in N-methyl-n-nitrosourea-induced lymphomas in mice.
Topics: Animals; Animals, Newborn; Cocarcinogenesis; Lymphoma; Methylnitrosourea; Mice; Neoplasms, Experimental; Retroviridae; Thymus Gland; Thymus Neoplasms; Virus Activation | 1981 |
The influence of sodium selenite on tumor induction by methylnitrosourea (MNU) in rats.
Topics: Animals; Female; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Selenious Acid; Selenium | 1981 |
Cytogenetics of murine thymic lymphomas induced by N-methyl-N-nitrosourea: difference in incidence of trisomy 15 in thymic lymphomas induced in neonatal and adult mice.
Topics: Age Factors; Animals; Animals, Newborn; Chromosome Aberrations; Chromosome Banding; Karyotyping; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Thymus Neoplasms; Trisomy | 1981 |
[Principal fields of research into the pathogenesis of gliomas (author's transl)].
Topics: Animals; Brain Neoplasms; DNA Tumor Viruses; Dogs; Ethylnitrosourea; Female; Glioma; Humans; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Retroviridae | 1981 |
Mouse colostomy model for studies on large bowel cancer.
Topics: Animals; Colonic Neoplasms; Colostomy; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Rectal Neoplasms; Transplantation, Isogeneic | 1980 |
Chemoprevention of development of colonic adenomatosis and carcinomatosis with intrarectal dose of 5-FU on animal model.
Topics: Adenoma; Animals; Colonic Neoplasms; Female; Fluorouracil; Injections, Intraperitoneal; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Rectum | 1980 |
Protective effect of plant sterols against chemically induced colon tumors in rats.
Topics: Animals; Bile Acids and Salts; Cholesterol; Colonic Neoplasms; Diet; Diet, Vegetarian; Feces; Humans; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Sitosterols | 1980 |
Endoscopic detection of experimentally induced colonic neoplasms in guinea pigs (Cavia porcellus).
Topics: Animals; Colonic Neoplasms; Colonoscopes; Colonoscopy; Female; Guinea Pigs; Male; Methylnitrosourea; Neoplasms, Experimental; Rodent Diseases | 1980 |
Ortho-toluene sulphonamide and saccharin in the promotion of bladder cancer in the rat.
Topics: Animals; Body Weight; Drinking; Eating; Female; Kidney; Methylnitrosourea; Neoplasms, Experimental; Organ Size; Rats; Saccharin; Sulfonamides; Toluene; Tosyl Compounds; Urinary Bladder; Urinary Bladder Neoplasms | 1980 |
On the development of metastasizing tumors of the rat thyroid gland after combined administration of nitrosomethylurea and methylthiouracil.
Topics: Animals; Female; Lung; Lung Neoplasms; Methylnitrosourea; Methylthiouracil; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Thyroid Gland; Thyroid Neoplasms | 1980 |
Chemopreventive activity of tamoxifen, N-(4-hydroxyphenyl)retinamide, and the vitamin D analogue Ro24-5531 for androgen-promoted carcinomas of the rat seminal vesicle and prostate.
Topics: Androgens; Animals; Anticarcinogenic Agents; Calcitriol; Carcinogens; Drug Screening Assays, Antitumor; Male; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Prostate; Prostatic Neoplasms; Rats; Seminal Vesicles; Tamoxifen; Testosterone | 1995 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylhydrazines; Drug Screening Assays, Antitumor; Ellagic Acid; Gastrointestinal Neoplasms; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Multiple Primary; Nitrosamines; Quercetin; Random Allocation; Rats; Rats, Inbred F344 | 1995 |
Protection by grafts of embryonal rat tissues (teratomas) against induction and transplantation of malignant tumors.
Topics: Animals; Female; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Rats, Inbred BUF; Rats, Sprague-Dawley; Teratoma | 1995 |
Silicone implants and the inhibition of cancer.
Topics: Age Factors; Animals; Back; Breast Implants; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Peritoneal Cavity; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Silicones | 1995 |
[Effects of light deprivation on carcinogenesis induced by N-nitrosomethylurea in female rats].
Topics: Adenocarcinoma; Adenoma; Animals; Blindness; Female; Fibroadenoma; Leukemia, Experimental; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Pineal Gland; Pituitary Neoplasms; Rats; Thyroid Neoplasms; Time Factors | 1994 |
Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Ethylnitrosourea; Female; Guanine; Liver; Methylnitrosourea; Methyltransferases; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344 | 1994 |
Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status.
Topics: Animals; Base Sequence; Female; Gene Amplification; Genes, p53; Harderian Gland; Hyperplasia; Lymphoma; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred DBA; Mice, Transgenic; Molecular Sequence Data; Neoplasm Proteins; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Thymus Neoplasms | 1994 |
Age and dose-dependent carcinogenic effects of N-nitrosomethylurea administered intraperitoneally in a single dose to young and adult female mice.
Topics: Age Factors; Aging; Animals; Autoradiography; Chi-Square Distribution; DNA Damage; Dose-Response Relationship, Drug; Female; Injections, Intraperitoneal; Methylnitrosourea; Mice; Neoplasms, Experimental | 1993 |
Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model.
Topics: Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinoma in Situ; Carcinoma, Squamous Cell; Catechols; Cocarcinogenesis; Dimethylhydrazines; Disease Models, Animal; Drug Interactions; Eating; Epithelium; Hyperplasia; Liver; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Size; Rats; Rats, Inbred F344; Sodium Nitrite; Stomach; Stomach Neoplasms | 1993 |
Effects of X-irradiation on N-methyl-N-nitrosourea-induced multi-organ carcinogenesis in rats.
Topics: Adenocarcinoma; Animals; Body Weight; Digestive System Neoplasms; Female; Kidney Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Organ Size; Rats; Rats, Inbred ACI; Sex Characteristics; Uterine Neoplasms; X-Rays | 1993 |
Influence of aging on multi-organ carcinogenesis in rats induced by N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Aging; Animals; Bromodeoxyuridine; Deoxyguanosine; DNA; Intestinal Neoplasms; Lymphoma; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Splenic Neoplasms; Thymus Neoplasms; Tongue Neoplasms | 1993 |
No enhancing effects of calcium/magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay.
Topics: Animals; Ascorbic Acid; Body Weight; Carcinogens; Diethylnitrosamine; Glutamates; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Size; Rats; Rats, Inbred F344 | 1993 |
Targeted expression of human O(6)-methylguanine-DNA methyltransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis.
Topics: Animals; DNA Repair; Gene Expression Regulation, Enzymologic; Humans; Keratins; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Papilloma; Promoter Regions, Genetic; RNA, Messenger; Skin Neoplasms; Transgenes | 1996 |
Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Adenoma; Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carcinogens; Cyclohexenes; Diet; Diethylnitrosamine; Dimethylhydrazines; Kidney; Kidney Neoplasms; Limonene; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Terpenes | 1996 |
Alterations in DNA and cell membranes in an initiation process of carcinogenesis by N-nitrosourea.
Topics: Alkylating Agents; Alkylation; Animals; Binding Sites; Carcinogens; Cell Membrane; DNA; Guanine; Hydrogen Bonding; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Specificity; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Stomach | 1995 |
Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Cyclophosphamide; Diethylnitrosamine; Female; Genes, ras; Humans; Male; Methylazoxymethanol Acetate; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental | 1996 |
Colon carcinogenesis in shrews by intrarectal infusion of N-methyl-N-nitrosourea.
Topics: Administration, Rectal; Animals; Carcinogens; Colonic Neoplasms; Drug Administration Schedule; Female; Methylnitrosourea; Neoplasms, Experimental; Shrews | 1996 |
K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors.
Topics: Adenine; Animals; Bromodeoxyuridine; Carcinogens; Codon; Female; Genes, ras; Guanine; Kidney Neoplasms; Male; Mesenchymoma; Methylnitrosourea; Neoplasms, Experimental; Point Mutation; Polymerase Chain Reaction; Rats | 1996 |
Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; DNA Mutational Analysis; Gene Deletion; Genes, p53; Genes, ras; Genes, Tumor Suppressor; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Stomach Neoplasms | 1997 |
Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Drug Synergism; Indoles; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Sprague-Dawley; Thyroid Neoplasms | 1997 |
Demonstration of ras and p53 gene mutations in carcinomas in the forestomach and intestine and soft tissue sarcomas induced by N-methyl-N-nitrosourea in the rat.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Genes, p53; Genes, ras; Intestinal Neoplasms; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Papilloma; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred F344; Sarcoma, Experimental; Sequence Analysis, DNA; Stomach Neoplasms | 1997 |
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Carcinogens; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasms, Experimental; Ornithine Decarboxylase Inhibitors; Rats; Rats, Sprague-Dawley; Skin Neoplasms | 1997 |
Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase.
Topics: Animals; Carcinogens; Codon; DNA-Binding Proteins; Genes, ras; LIM Domain Proteins; Lymphoma; Metalloproteins; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Oncogene Proteins; Point Mutation; Thymus Neoplasms; Transcription Factors | 1997 |
[The influence of melatonin on mutagenicity and antitumor action of cytostatic drugs in mice].
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Male; Melatonin; Methylnitrosourea; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Neoplasms, Experimental; Sperm Head | 1997 |
Studies of initiation and promotion of carcinogenesis by N-nitroso compounds.
Topics: Animals; Carcinogens; Carcinoma, Transitional Cell; Diethylnitrosamine; Ethylnitrosourea; Male; Methylnitrosourea; Mutagens; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Inbred F344; Survival Rate; Urinary Bladder Neoplasms | 1998 |
Modulation of methylnitrosourea-induced breast cancer in Sprague Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations.
Topics: Animals; Cell Division; Coenzyme A Ligases; Dehydroepiandrosterone; Diet; Dose-Response Relationship, Drug; Female; Genes, ras; Mammary Neoplasms, Animal; Methylnitrosourea; Microbodies; Mutation; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley | 1998 |
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes.
Topics: Adaptor Proteins, Signal Transducing; Alkylating Agents; Animals; Carrier Proteins; DNA Repair; Female; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Knockout; MutL Protein Homolog 1; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Survival Analysis; Thymus Neoplasms | 1998 |
Initial levels of azoxymethane-induced DNA methyl adducts are not predictive of tumor susceptibility in inbred mice.
Topics: Animals; Azoxymethane; Biotransformation; Carcinogens; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Guanine; Immunoblotting; Male; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Neoplasms, Experimental; Predictive Value of Tests | 1998 |
Pre-treatment energy status of primary rat tumours as the best predictor of response to 5-fluorouracil chemotherapy: a magnetic resonance spectroscopy study in vivo.
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Carcinogens; Energy Metabolism; Female; Fluorouracil; Magnetic Resonance Spectroscopy; Methylnitrosourea; Neoplasms, Experimental; Organ Size; Rats; Rats, Wistar | 1998 |
Rapid induction of malignant tumors by chemical carcinogens in rats carrying the Grc.
Topics: Animals; Carcinogens; Dioxanes; Female; Gene Deletion; Genes, Tumor Suppressor; Male; Methylnitrosourea; Neoplasms, Experimental; Phenacetin; Rats | 1999 |
Effects of melatonin on N-nitroso-N-methylurea-induced carcinogenesis in rats and mutagenesis in vitro (Ames test and COMET assay).
Topics: Animals; Antimutagenic Agents; DNA Damage; Female; Melatonin; Methylnitrosourea; Neoplasms, Experimental; Rats; Salmonella typhimurium | 1999 |
Chemopreventive effect of 24R,25-dihydroxyvitamin D(3) in N, N'-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 24,25-Dihydroxyvitamin D 3; Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carcinogens; Colonic Neoplasms; Diet; Diethylnitrosamine; Intestinal Mucosa; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344 | 2000 |
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice.
Topics: Adaptor Proteins, Signal Transducing; Alkylating Agents; Alleles; Animals; Carcinogens; Carrier Proteins; Codon; Disease Progression; DNA Mutational Analysis; DNA, Neoplasm; Gene Deletion; Genes, ras; Genetic Predisposition to Disease; Genotype; Intestinal Neoplasms; Lethal Dose 50; Lymphoma; Methylnitrosourea; Mice; Mice, Knockout; MutL Protein Homolog 1; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Thymus Neoplasms | 2000 |
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Alkylating Agents; Animals; Body Weight; Butylhydroxybutylnitrosamine; Carcinogenicity Tests; Carcinogens; Concanavalin A; Diethylnitrosamine; Flow Cytometry; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Wistar; Spleen; T-Lymphocyte Subsets; Tissue Distribution | 2000 |
In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Carcinogens; Comet Assay; Female; Glutathione Peroxidase; Liver; Lyases; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasms, Experimental; Organoselenium Compounds; Rats; Rats, Sprague-Dawley; Selenium; Thioredoxin-Disulfide Reductase; Tissue Distribution; Tumor Cells, Cultured | 2000 |
Dietary restriction during murine development provides protection against MNU-induced mutations.
Topics: Animals; Base Sequence; DNA Primers; Energy Intake; Feeding Behavior; Female; Genetic Predisposition to Disease; Litter Size; Methylnitrosourea; Mice; Mutation; Neoplasms, Experimental; Pregnancy; Transcription Factors; Viral Proteins | 2000 |
Antitumoral effect of recombinant mistletoe lectin on chemically induced urinary bladder carcinogenesis in a rat model.
Topics: Adjuvants, Immunologic; Administration, Intravesical; Alkylating Agents; Animals; Cell Transformation, Neoplastic; Female; Methylnitrosourea; Neoplasms, Experimental; Plant Preparations; Plant Proteins; Rats; Recombinant Proteins; Ribosome Inactivating Proteins, Type 2; Toxins, Biological; Urinary Bladder Neoplasms; Urothelium | 2001 |
The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats.
Topics: Animals; Buformin; Cholesterol; Dietary Carbohydrates; Diethylstilbestrol; Energy Metabolism; Female; Glucose Tolerance Test; Hypertrophy; Hypoglycemic Agents; Hypothalamo-Hypophyseal System; Insulin; Kidney Neoplasms; Male; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Nerve Tissue; Nervous System Neoplasms; Ovariectomy; Ovary; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Somatomedins | 1980 |
Twenty-six-week carcinogenicity study of sulfamethoxazole in CB6F1-Tg-rasH2 mice.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Female; Genes, ras; Harderian Gland; Humans; Hyperplasia; Lung Neoplasms; Male; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasms, Experimental; Splenic Neoplasms; Sulfamethoxazole; Thyroid Gland | 2001 |
Reduction of 1-methyl-1-nitrosourea-induced mammary gland carcinoma by in vivo application of immunostimulatory CpG motifs in Sprague-Dawley rats.
Topics: Alkylating Agents; Amino Acid Motifs; Animals; Carcinogens; CpG Islands; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Models, Statistical; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Tretinoin | 2001 |
[Possibilities for the spread of alpha-fetoprotein and heterologous antibodies in mother and fetus during transplacental carcinogenesis].
Topics: Age Factors; alpha-Fetoproteins; Animals; Antibodies; Female; Fetal Proteins; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Organ Specificity; Pregnancy; Pregnancy Complications; Rats | 1975 |
[Various aspects of transplacental blastomogenesis in rabbits].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Ethylnitrosourea; Female; Kidney Neoplasms; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Pregnancy; Rabbits; Sciatic Nerve | 1978 |
[Different sensitivity of DNA synthesis in normal and tumor cells to exposure to several N-alkyl-N-nitrosoureas].
Topics: Animals; Bone Marrow; DNA; DNA, Neoplasm; Hybridization, Genetic; Intestinal Mucosa; Melanoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Mustard Compounds; Neoplasms, Experimental; Nitrosourea Compounds; Streptozocin | 1979 |
Organ-specific effects of DNA methylation by alkylating agents in the inbred Swiss mouse.
Topics: Alkylating Agents; Animals; Bone Marrow; DNA; Female; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Organ Specificity; Spleen; Thymus Gland; Time Factors | 1975 |
Utilization of in vivo alkylated metabolites as a possible cause of increased sensitivity to tumor cells to alkylating agents.
Topics: Animals; Carcinoma, Hepatocellular; DNA, Neoplasm; Leukemia L1210; Liver; Liver Neoplasms; Methylnitrosourea; Mice; Mice, Inbred Strains; Molecular Weight; Neoplasm Proteins; Neoplasms, Experimental; Nitrosourea Compounds; RNA, Neoplasm; Time Factors | 1975 |
Lipid composition of experimental astrocytomas originating from transformed rat and hamster astrocyte cultures.
Topics: Animals; Astrocytoma; Cell Line; Cricetinae; Lipids; Methylnitrosourea; Neoplasms, Experimental; Rats; Simian virus 40 | 1976 |
[Long-term cultures of experimental CNS tumours as models in neurooncological research (author's transl)].
Topics: Animals; Brain Neoplasms; Bucladesine; Cell Division; Cell Transformation, Neoplastic; Culture Techniques; Ethylnitrosourea; Glioma; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Rats; Rats, Inbred Strains; Time Factors | 1976 |
[Analysis of macromolecule alkylation in tissues of intact and tumor carrying mice].
Topics: Alkylation; Animals; Brain; Carcinoma, Hepatocellular; DNA Repair; Lipid Metabolism; Liver; Liver Neoplasms; Methylnitrosourea; Mice; Neoplasms, Experimental; Proteins; RNA; Spleen | 1976 |
[Tumor growth and protein synthesis in mouse hepatoma 22A cells under antitumor effect of N-methyl-N-nitrosourea].
Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Methylnitrosourea; Mice; Neoplasm Proteins; Neoplasms, Experimental; Nitrosourea Compounds | 1977 |
Discussion: some comments on the potential carcinogenicity of the clinically useful antitumor agents.
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Haplorhini; Humans; Liver Neoplasms; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Multiple Primary; Procarbazine; Registries | 1977 |
Hepatocarcinogenic effects of N-nitroso-N-methylurea in guinea pigs.
Topics: Adenoma, Bile Duct; Animals; Chemical and Drug Induced Liver Injury; Guinea Pigs; Hemangiosarcoma; Liver Diseases; Liver Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds | 1977 |
[Neurogenic stomach neoplasms induced by nitrosomethylures in Syrian hamsters].
Topics: Animals; Cricetinae; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Nerve Tissue; Papilloma; Rhabdomyosarcoma; Stomach Neoplasms | 1977 |
[The influence of renal artery occlusion on tumor growth of experimental nephroblastomas (author's transl)].
Topics: Animals; Embolization, Therapeutic; Female; Kidney Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Time Factors; Wilms Tumor | 1977 |
[Degradation and repair of rat hepatoma cell DNA following exposure to gamma rays and methylnitrosourea].
Topics: Animals; Carcinoma, Hepatocellular; DNA Polymerase I; DNA Repair; DNA, Neoplasm; Gamma Rays; Liver Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1977 |
Sensitivity difference of rat ascites hepatoma AH-13 and mouse leukemia L-1210 to nitrosourea derivatives.
Topics: Animals; Carcinoma, Hepatocellular; Leukemia L1210; Liver Neoplasms; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Structure-Activity Relationship | 1978 |
Induction of neurogenic tumors by nitrosotrialkylureas in rats.
Topics: Animals; Drug Stability; Ethylnitrosourea; Female; Hydrogen-Ion Concentration; Male; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Nerve Tissue; Nitrosourea Compounds; Rats; Solutions; Water | 1975 |
Nitrosourea-induced brain tumors: an in vivo and in vitro tumor model system.
Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Immunosuppression Therapy; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Thymus Gland; Time Factors; Transplantation, Isogeneic | 1978 |
Chemical carcinogenesis and immunity: immunologic status of rats treated with methylnitrosourea.
Topics: Animals; Antibody Formation; Hyperplasia; Immunity; Immunosuppression Therapy; Lymphocytes; Lymphoid Tissue; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Stomach Neoplasms; Teichoic Acids | 1978 |
Pathogenesis of rat colon carcinomas induced by N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Humans; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Species Specificity | 1978 |
Cytologic correlates of chemical carcinogens in respiratory tracts of dogs.
Topics: Animals; Benzopyrenes; Cell Nucleolus; Cell Nucleus; Cytodiagnosis; Cytoplasm; Dogs; Epithelium; Lung Neoplasms; Metaplasia; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Precancerous Conditions; Time Factors | 1978 |
Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats.
Topics: Animals; Azoxymethane; Cellulose; Colonic Neoplasms; Dietary Fiber; Female; Medicago sativa; Methylnitrosourea; Neoplasms, Experimental; Pectins; Rats; Rats, Inbred F344; Triticum | 1979 |
[Experiments on rhesus-monkeys (Macaca mulatta) with the carcinogens methyl- and ethylnitrosourea (author's transl)].
Topics: Animals; Ethylnitrosourea; Female; Fetus; Haplorhini; Macaca mulatta; Male; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Time Factors | 1977 |
[In vitro malignant transformation of fetal hamster brain cells by methylnitrosourea].
Topics: Animals; Brain; Brain Neoplasms; Cell Transformation, Neoplastic; Cricetinae; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neuroglia; Nitrosourea Compounds | 1977 |
[Comparative study of the action of carcinogenic substances that induce transplacental blastomogenesis in rabbits].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Carcinogens; Ethylnitrosourea; Female; Male; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Placenta; Pregnancy; Rabbits; Time Factors | 1978 |
[Development of experimental peripheral nerve tumors in hormonal imbalance].
Topics: Animals; Castration; Female; Gonadal Steroid Hormones; Hexestrol; Homeostasis; Methimazole; Methylnitrosourea; Neoplasms, Experimental; Peripheral Nervous System Neoplasms; Rats; Thyroid Hormones; Time Factors | 1979 |
[Ultrastructure of tumors arising from Schwann cells].
Topics: Animals; Female; Male; Methylnitrosourea; Microscopy, Electron; Neoplasms, Experimental; Neurilemmoma; Peripheral Nervous System Neoplasms; Rats; Schwann Cells | 1979 |
[Clonogenic cell response of murine NK Ly/LL solid tumor to N-methyl-N-nitrosourea].
Topics: Animals; Cell Survival; Clone Cells; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; In Vitro Techniques; Methylnitrosourea; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds | 1979 |
Mechanism of perinatal tumor induction by neuro-oncogenic alkylnitrosoureas and dialkylaryltriazenes.
Topics: Animals; Brain; DNA; DNA Repair; Female; Fetus; Guanine; Liver; Maternal-Fetal Exchange; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nervous System Diseases; Nitrosourea Compounds; Pregnancy; Rats; Triazenes | 1979 |
[Cellular capacity in tissue culture and in tumors for recovery from the injuries induced by N-methyl-N-nitrosourea].
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Clone Cells; Dose-Response Relationship, Drug; In Vitro Techniques; Methylnitrosourea; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Time Factors | 1979 |
Effect of graded dietary levels of selenium on tracheal carcinomas induced by 1-methyl-1-nitrosourea.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Male; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Selenium; Tracheal Neoplasms | 1979 |
[Morphology and classification of brain tumors induced by methylnitrosourea in rabbits (author's transl)].
Topics: Animals; Astrocytoma; Brain Neoplasms; Glioma; Methylnitrosourea; Neoplasms, Experimental; Oligodendroglioma; Rabbits; Sarcoma | 1979 |
Studies with a new experimental model in respiratory carcinogenesis.
Topics: Animals; Cricetinae; Disease Models, Animal; Methods; Methylnitrosourea; Mucous Membrane; Neoplasms, Experimental; Time Factors; Trachea; Tracheal Neoplasms | 1979 |
1-methyl-1-nitrosourea induction of cancer in a localized area of the Syrian golden hamster trachea.
Topics: Adenocarcinoma; Animals; Cricetinae; Disease Models, Animal; Male; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Tracheal Neoplasms | 1979 |
Pathology of tumors developed in guinea pigs given intraperitoneal injections of N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Fibrosarcoma; Guinea Pigs; Hemangiosarcoma; Injections, Intraperitoneal; Intestinal Neoplasms; Male; Mesentery; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pancreatic Neoplasms | 1977 |
Influence of dose of N-methyl-N-nitrosourea on the induction of urinary bladder cancer in rats.
Topics: Animals; Carcinoma, Transitional Cell; Dose-Response Relationship, Drug; Female; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Urethra; Urinary Bladder Neoplasms; Urinary Catheterization | 1979 |
Fibrin degradation products, produced by glioma cell-associated fibrinolysis and the partial inhibition of cell growth and migration in tissue culture.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Migration Inhibition; Culture Techniques; Fibrin Fibrinogen Degradation Products; Fibrinolysis; Glioma; Methylnitrosourea; Microscopy, Electron; Neoplasms, Experimental; Plasminogen Activators; Rabbits; Rats; Tranexamic Acid | 1979 |
Differential distribution of antitumor agents in primary and secondary tumors.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma 256, Walker; Cyclophosphamide; Daunorubicin; Doxorubicin; Female; Hydroxyurea; Lung Neoplasms; Lymphatic Metastasis; Male; Mercaptopurine; Methotrexate; Methylnitrosourea; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Rats; Sarcoma, Experimental | 1977 |
[Comparative cytological and histological investigations of experimental thyroid tumors in the rat (author's transl)].
Topics: Animals; Cytodiagnosis; Female; Methylnitrosourea; Methylthiouracil; Neoplasms, Experimental; Rats; Thyroid Neoplasms | 1977 |
Induction of tumors of peripheral nervous system in female Donryu rats by continuous oral administration of 1-methyl-1-nitrosourea.
Topics: Administration, Oral; Animals; Brain Neoplasms; Female; Methylnitrosourea; Neoplasms, Experimental; Neuroma; Nitrosourea Compounds; Peripheral Nervous System Neoplasms; Rats; Spinal Cord Neoplasms | 1977 |
Tumor induction in the trachea of hamsters with N-nitroso-N-methylurea.
Topics: Adenocarcinoma; Animals; Carcinoma in Situ; Carcinoma, Squamous Cell; Cricetinae; Male; Mesocricetus; Methylnitrosourea; Neoplasm Metastasis; Neoplasms, Experimental; Nitrosourea Compounds; Time Factors; Tracheal Neoplasms | 1978 |
Neoplasms in purebred boxer dogs following long-term administration of N-methyl-N-nitrosourea.
Topics: Animals; Carcinoma; Dogs; Female; Hemangioma; Intestinal Neoplasms; Intestine, Small; Lymphoma; Male; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Sarcoma, Experimental; Species Specificity; Time Factors | 1978 |
Morphologic aspects of experimental canine bronchial carcinogen exposure.
Topics: Animals; Benzopyrenes; Bronchial Neoplasms; Dogs; Epithelium; Methylnitrosourea; Neoplasms, Experimental; Time Factors | 1978 |
Dose response to intrarectal administration of N-methyl-N-nitrosourea and histopathologic evaluation of the effect of two retinoids on colon lesions induced in rats.
Topics: Adenocarcinoma; Administration, Oral; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Injections; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rectum; Tretinoin; Vitamin A | 1978 |
[Combined transplacental carcinogenic action of N-nitrosomethylurea (NMU) and N-nitrosoethylurea (NEU) in rats].
Topics: Animals; Brain Neoplasms; Carcinogens; Dose-Response Relationship, Drug; Drug Interactions; Ethylnitrosourea; Female; Gestational Age; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Placenta; Pregnancy; Rats; Teratogens | 1978 |
Methylnitrosophenylurea--a highly carcinogenic compound.
Topics: Animals; Carcinogens, Environmental; Carcinoma, Squamous Cell; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Rats; Stomach Neoplasms | 1978 |
Genetic basis of susceptibility for development of neoplasms following treatment with N-methyl-N-nitrosourea (MNU) or x-rays in the platyfish/swordtail system.
Topics: Animals; Chromosomes; Female; Fishes; Genotype; Male; Methylnitrosourea; Mutation; Neoplasms, Experimental; Neoplasms, Radiation-Induced | 1978 |
Cancer chemotherapy model using autochthonous large bowel cancer in rats.
Topics: Administration, Topical; Animals; Drug Evaluation, Preclinical; Female; Fluorouracil; Intestinal Neoplasms; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Semustine | 1978 |
Tumor specific fluorescent and complement-dependent cytotoxic antibodies in the serum of rats with chemically induced brain gliomas.
Topics: Animals; Antibodies, Neoplasm; Astrocytoma; Brain Neoplasms; Cell Line; Complement System Proteins; Glioma; Methylnitrosourea; Neoplasms, Experimental; Oligodendroglioma; Rats; S100 Proteins | 1978 |
[Effect of chloramphenicol on the blastomogenic effect of N-nitrosomethylurea].
Topics: Animals; Antineoplastic Agents; Chloramphenicol; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Reaction Time | 1978 |
Induction of tumors in heterotopic bladder by topical application of N-methyl-N-nitrosourea and N-butyl-N-(3-carboxypropyl)nitrosamine.
Topics: Animals; Carcinoma, Transitional Cell; Disease Models, Animal; Female; Hyperplasia; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Nitrosourea Compounds; Propionates; Rats; Rats, Inbred Strains; Transplantation, Isogeneic; Urinary Bladder; Urinary Bladder Neoplasms | 1978 |
The significance of some modifying factors during transplacental blastomogenesis by ethylnitrosourea in rabbits.
Topics: Animals; Antigens; Ethylnitrosourea; Female; Kidney Neoplasms; Male; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nerve Tissue; Nitrosourea Compounds; Peripheral Nervous System Neoplasms; Physical Stimulation; Pregnancy; Rabbits; Sciatic Nerve | 1978 |
Experiments on the chemotheraphy of a transplantable glioblastoma in the rat, employing 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU).
Topics: Animals; Brain Neoplasms; Glioma; Lomustine; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1978 |
Effects of carcinogen dose on the characteristics of the tracheal tumor response induced by N-nitroso-N-methylurea in hamsters.
Topics: Adenocarcinoma; Animals; Atrophy; Carcinoma in Situ; Carcinoma, Squamous Cell; Cricetinae; Dose-Response Relationship, Drug; Hyperplasia; Male; Mesocricetus; Metaplasia; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Precancerous Conditions; Time Factors; Trachea; Tracheal Neoplasms | 1978 |
[Type-C viral particles in cell cultures of chemically induced glioma in Sprague-Dawley rats].
Topics: Animals; Cells, Cultured; Glioma; Inclusion Bodies, Viral; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains | 1978 |
[Significance of modifying factors in the development of peripheral nervous system tumors in rabbits].
Topics: Animals; Homeostasis; Immunization; Methylnitrosourea; Neoplasms, Experimental; Peripheral Nervous System Neoplasms; Rabbits | 1978 |
Effect of dietary undegraded carrageenan on colon carcinogenesis in F344 rats treated with azoxymethane or methylnitrosourea.
Topics: Animals; Azo Compounds; Azoxymethane; Carrageenan; Cellulose; Colonic Neoplasms; Dietary Fiber; Female; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rectal Neoplasms | 1978 |
Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid
Topics: Alkylation; Animals; Carcinogens; DNA; Ethyl Methanesulfonate; Ethylnitrosourea; Lymphoma; Methylnitrosourea; Mice; Neoplasms, Experimental; Thymus Neoplasms; Tissue Distribution | 1978 |
Genetic basis of susceptibility for neuroblastoma following treatment with N-methyl-N-nitrosourea and X-rays in Xiphophorus.
Topics: Animals; Eye Neoplasms; Fishes; Genes, Regulator; Genotype; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Neuroblastoma; Nitrosourea Compounds; X-Rays | 1979 |
Prophylaxis of bladder tumor implantation. Intravesical and systemic chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Disease Models, Animal; Doxorubicin; Female; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin; Thiotepa; Urinary Bladder; Urinary Bladder Neoplasms | 1976 |
Some results and prospects of transplacental carcinogenesis studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Animals; Brain; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nervous System Diseases; Nitrosourea Compounds; Organ Specificity; Placenta; Pregnancy; Rats | 1976 |
Screening of potential chemical carcinogens by means of mammalian cells in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cells, Cultured; Cricetinae; DDT; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Ethylnitrosourea; Female; Guinea Pigs; In Vitro Techniques; Methylnitrosourea; Mice; Neoplasms, Experimental; Pregnancy; Rats | 1976 |
Comparative study of the carcinogenic activities of nas and some chemical carcinogens when introduced into the buccal pouch of the Syrian hamster.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cheek; Cricetinae; Diethylnitrosamine; Dimethylnitrosamine; Female; Male; Mesocricetus; Methylnitrosourea; Mouth Mucosa; Mouth Neoplasms; Neoplasms, Experimental; Nicotiana; Plants, Toxic | 1976 |
Techniques for localized injections and topical applications of carcinogens at specific endobronchial sites in dogs.
Topics: Administration, Topical; Animals; Benzopyrenes; Bronchoscopes; Carcinogens; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Dogs; Injections; Lung Neoplasms; Methylnitrosourea; Neoplasms, Experimental | 1977 |
13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat.
Topics: Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Female; Methylnitrosourea; Neoplasms, Experimental; Rats; Tretinoin; Urinary Bladder Neoplasms; Vitamin A | 1977 |
Alkylation of rat liver DNA by dimethylnitrosamine: effect of dosage on O6-methylguanine levels.
Topics: Alkylating Agents; Animals; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Female; Guanine; Liver; Liver Neoplasms; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats | 1977 |
Short and long term effects of methyl- and ethylnitrosourea (MNU & ENU) on the developing nervous system of the rat. II. Short term effects: concluding remarks on chemical neuro-oncogenesis.
Topics: Age Factors; Animals; Animals, Newborn; Chromosomes; Dose-Response Relationship, Drug; Ethylnitrosourea; Methylnitrosourea; Mitosis; Neoplasms, Experimental; Nitrosourea Compounds; Organ Specificity; Rats; Rats, Inbred Strains; Time Factors | 1977 |
Short and long term effects of methyl- and ethylnitrosourea (MNU & ENU) on the developing nervous system of the rat. I. Long term effects: the induction of (multiple) gliomas.
Topics: Age Factors; Animals; Animals, Newborn; Brain Neoplasms; Ethylnitrosourea; Female; Glioma; Male; Meningioma; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Multiple Primary; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Spinal Cord Neoplasms | 1977 |
Effect of age, sex, and intestinal flora on the induction of colon tumors in rats.
Topics: Adenocarcinoma; Age Factors; Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Germ-Free Life; Intestines; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Sex Factors; Time Factors; Transplantation, Homologous | 1977 |
[Induction of malformations by N-methyl-N-nitrosourea (MNU) (author's transl))].
Topics: Animals; Disease Models, Animal; Female; Fetus; Humans; Infant, Newborn; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats | 1977 |
Tumors of the heart and stomach induced in European hamsters by intravenous administration of N-methyl-N-nitrosourea.
Topics: Animals; Cricetinae; Female; Fibrosarcoma; Heart Neoplasms; Injections, Intravenous; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Sex Factors; Stomach Neoplasms | 1977 |
Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid.
Topics: Animals; Epithelium; Female; Methylnitrosourea; Neoplasms, Experimental; Precancerous Conditions; Rats; Statistics as Topic; Tretinoin; Urinary Bladder Neoplasms; Vitamin A | 1977 |
The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.
Topics: 2-Naphthylamine; Animals; Carcinogens; Carcinogens, Environmental; Carcinoma, Transitional Cell; Cyclamates; Drug Synergism; Female; Humans; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Saccharin; Urinary Bladder Neoplasms | 1977 |
Morphology and pathogenesis of tumors of the thymus and stomach in Sprague-Dawley rats following intragastric administration of methyl nitrosourea (MNU).
Topics: Animals; Lymphoma; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Stomach Neoplasms; Thymus Neoplasms; Time Factors | 1977 |
Effect of high-fat diet on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanol acetate, or methylnitrosourea.
Topics: Adenocarcinoma; Adenoma; Animals; Azo Compounds; Cattle; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Male; Meat; Methylazoxymethanol Acetate; Methylhydrazines; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Rats, Inbred F344 | 1977 |
The autoradiographic pattern of DNA synthesis in Papova virus- and N-methyl-N-nitroso urea (MNU)-induced skin tumors of the Syrian hamster (Mesocricetus auratus).
Topics: Animals; Autoradiography; Cricetinae; DNA, Neoplasm; Methylnitrosourea; Neoplasms, Experimental; Papillomaviridae; Polyomaviridae; Skin Neoplasms | 1977 |
[Proteinases and chemotherapy of malignant human tumors].
Topics: Animals; Cathepsins; Chemical Phenomena; Chemistry; Humans; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Sarcoma, Experimental | 1977 |
Chemical induction of brain tumors.
Topics: Animals; Brain Neoplasms; Carcinogens; Cricetinae; Dogs; Female; Hydrocarbons; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Rats; Thymectomy; Triazenes | 1976 |
Repair excision of alkylated bases from DNA in vivo.
Topics: Alkylating Agents; Animals; Brain; Carcinogens; DNA Repair; Guanine; Kidney; Liver; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats | 1976 |
Leukemias and vaginal tumors induced in female Donryu rats by continuous administration of 1-butyl-3,3-dimethyl-1-nitrosourea in the drinking water.
Topics: Animals; Ear Neoplasms; Female; Leukemia, Experimental; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Vaginal Neoplasms | 1976 |
[Induction of tumors of the stomach in mini-pigs by methylnitrosourea administration (author's transl)].
Topics: Anaplasia; Animals; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Organ Specificity; Polyps; Species Specificity; Stomach Neoplasms; Swine | 1976 |
Carcinogenic effects of different nitroso-compounds in chinese hamsters: N-dibutylnitrosamine and N-nitrosomethylurea.
Topics: Animals; Cricetinae; Female; Lethal Dose 50; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Nitrosourea Compounds | 1976 |
[Papillomas of the urinary bladder induced by N-nitroso-N-methylurea in rats].
Topics: Animals; Female; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Rats; Urinary Bladder; Urinary Bladder Neoplasms | 1976 |
[Transplacental blastomogenic effect of N-nitrosomethylurea in rats with constant estrus].
Topics: Animals; Estrus; Female; Male; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats | 1976 |
Histological studies on early changes of the hamster gingival epithelium by N-nitrosomethylurea.
Topics: Animals; Cell Division; Connective Tissue; Cricetinae; Epithelial Attachment; Epithelium; Gingiva; Gingival Hyperplasia; Gingival Neoplasms; Male; Mesocricetus; Methylnitrosourea; Mitosis; Neoplasms, Experimental; Nitrosourea Compounds | 1976 |
Nitrosomethylurea-induced lymphomas in thymectomized mice, in relation to thymus-dependent and independent systems.
Topics: Adenoma; Animals; Cell Transformation, Neoplastic; Female; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Rats; T-Lymphocytes; Thymectomy; Thymus Neoplasms | 1975 |
Susceptibility of urothelium to neoplastic cellular implantation.
Topics: Animals; Carcinoma, Transitional Cell; Cystitis; Epithelium; FANFT; Female; Methylnitrosourea; Mice; Mice, Inbred C3H; Mucous Membrane; Neoplasm Transplantation; Neoplasms, Experimental; Time Factors; Urinary Bladder; Urinary Bladder Neoplasms | 1975 |
Pancreatic adenocarcinoma in inbred guinea pigs induced by n-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Female; Guinea Pigs; Intestinal Neoplasms; Lymphoma; Male; Mesentery; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pancreas; Pancreatic Ducts; Pancreatic Neoplasms; Sex Factors; Stomach Neoplasms; Time Factors | 1975 |
Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma; Chemical Phenomena; Chemistry; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Homologous | 1975 |
Tumours in the mammary gland induced in Lewis rats by intravenous methylnitrosurea.
Topics: Adenocarcinoma, Papillary; Animals; Brain Neoplasms; Female; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1975 |
Specific carcinogenic effect of N-methyl-N-nitrosourea on the midventral sebaceous gland of the gerbil (Meriones unguiculatus).
Topics: Adenoma; Animals; Carcinoma; Female; Gerbillinae; Injections, Intravenous; Lethal Dose 50; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Sebaceous Gland Neoplasms; Sex Factors | 1975 |
Histopathological studies of the nervous system tumors in rats induced by N-nitroso-methyl-urea.
Topics: Animals; Astrocytoma; Brain Neoplasms; Ependymoma; Female; Glioma; Maternal-Fetal Exchange; Meningioma; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Oligodendroglioma; Peripheral Nervous System Neoplasms; Pregnancy; Rats; Spinal Cord Neoplasms | 1975 |
Animal models for the study of dietary factors and cancer of the large bowel.
Topics: Animals; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Guinea Pigs; Intestines; Lithocholic Acid; Methylnitrosourea; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Rats; Taurocholic Acid; Vitamin A Deficiency | 1975 |
Induction of neurogenic and lymphoid neoplasms by the feeding of threshold levels of methyl- and ethylnitrousourea precursors to adult rats.
Topics: Animals; Brain Neoplasms; Ethylnitrosourea; Female; Lymphoma; Mammary Neoplasms, Experimental; Methylnitrosourea; Methylurea Compounds; Neoplasms, Experimental; Nitrites; Nitrosourea Compounds; Peripheral Nervous System Neoplasms; Pituitary Neoplasms; Rats; Urea | 1975 |
A colon tumor model for anticancer agent evaluation.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Homologous | 1975 |
[Proceedings: Experimental induction of gastric tumors in the miniature swine].
Topics: Animals; Intestinal Polyps; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Species Specificity; Stomach Neoplasms; Swine | 1975 |
[DNA-synthesis in the final stages of the S-phase and G-banding in neoplastic cells of the rat (author's transl)].
Topics: Animals; Autoradiography; Central Nervous System; Chromosomes; DNA; Methylnitrosourea; Mitosis; Neoplasms, Experimental; Rats | 1975 |
The roles of age at treatment and dose in carcinogenesis in C3Hf/Dp mice with a single administration of N-nitroso-N-methylurea.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitrosourea Compounds; Stomach Neoplasms; Thymus Neoplasms | 1976 |
Organ culture of normal and carcinogen-treated rat bladder.
Topics: Animals; Culture Media; Female; Methylnitrosourea; Neoplasms, Experimental; Organ Culture Techniques; Precancerous Conditions; Rats; Urinary Bladder; Urinary Bladder Neoplasms | 1976 |
[Carcinogenesis induced by the neonatal administration of 5-bromo-2'-deoxyuridine and subsequent exposure to N-nitrosomethylurea in rats].
Topics: Aging; Animals; Animals, Newborn; Bromodeoxyuridine; Drug Interactions; Female; Life Tables; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Sex Factors | 1992 |
N-alkyl-N-nitrosourea induced secondary structural changes in DNA from rat embryos and fetal brains in vivo.
Topics: Abnormalities, Drug-Induced; Animals; Brain; DNA; Embryo, Mammalian; Ethylnitrosourea; Female; Fetus; Methylnitrosourea; Neoplasms, Experimental; Nucleic Acid Conformation; Pregnancy; Rats; Rats, Wistar | 1992 |
Differences in skin carcinogenesis by methylnitrosourea between mice of several strains.
Topics: Animals; Disease Models, Animal; Female; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms | 1991 |
Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Drug Synergism; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Specificity; Rats; Rats, Inbred F344 | 1991 |
Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
Topics: Animals; Capsaicin; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1991 |
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Pepsinogens; Pylorus; Rats; Rats, Inbred F344; Stomach Neoplasms; Urinary Bladder Neoplasms | 1991 |
Embryotoxicity induced by alkylating agents: 6. DNA adduct formation induced by methylnitrosourea in mouse embryos.
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; DNA; DNA Repair; Embryo, Mammalian; Female; Guanine; Methylnitrosourea; Mice; Neoplasms, Experimental; Pregnancy | 1991 |
Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Topics: Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Disease Models, Animal; Germanium; Indoles; Kidney; Liver; Liver Neoplasms, Experimental; Lung; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Size; Rats; Rats, Inbred F344; Sulfides | 1991 |
Medium-term bioassay for carcinogens using multiorgan models.
Topics: Animals; Carcinogenicity Tests; Carcinogens, Environmental; Cocarcinogenesis; Disease Models, Animal; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344 | 1991 |
Dose-responsive induction of mammary gland carcinomas by the intraperitoneal injection of 1-methyl-1-nitrosourea.
Topics: Animals; Carcinoma; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Survival Analysis; Time Factors | 1991 |
Effects of naturally occurring antioxidants on combined 1,2-dimethylhydrazine- and 1-methyl-1-nitrosourea-initiated carcinogenesis in F344 male rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; beta Carotene; Carotenoids; Coumaric Acids; Dimethylhydrazines; Esculin; Eugenol; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Selenium | 1990 |
Effects of sex difference, gonadectomy, and estrogen on N-methyl-N-nitrosourea induced rat thyroid tumors.
Topics: Animals; Body Weight; Castration; Disease Models, Animal; Estradiol; Female; Gonadal Steroid Hormones; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Size; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Estrogen; Sex Factors; Thyroid Gland; Thyroid Neoplasms; Thyrotropin | 1990 |
A computer program for the statistical analysis of cancer inhibition/promotion experiments.
Topics: Animals; Antineoplastic Agents; Carcinogens; Computer Simulation; Diterpenes; Mammary Neoplasms, Experimental; Mathematical Computing; Methylnitrosourea; Models, Biological; Neoplasms, Experimental; Programming Languages; Rats; Retinyl Esters; Software; Software Design; Vitamin A | 1990 |
[Chromosomal damage in peripheral blood lymphocytes of rats in nitrosomethylurea-induced carcinogenesis].
Topics: Aneuploidy; Animals; Chromosome Aberrations; Female; Lymphocytes; Methylnitrosourea; Neoplasms, Experimental; Polyploidy; Prognosis; Rats | 1990 |
Experimental induction of neoplasia in the accessory sex organs of male Lobund-Wistar rats.
Topics: Adenocarcinoma; Animals; Genital Neoplasms, Male; Genitalia, Male; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Reference Values; Silicone Elastomers; Testosterone | 1990 |
[The inhibitory effect of the synthetic leu-enkephalin analog dalargin on carcinogenesis].
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Methylnitrosourea; Neoplasms, Experimental; Rats; Sympatholytics; Time Factors | 1990 |
Modulation of cytosolic sexual steroid receptors in autochthonous methylnitrosourea-induced rat mammary carcinoma following application of 2-chloroethylnitrosocarbamoyl-L-alanine linked to oestradiol or dihydrotestosterone.
Topics: Animals; Antineoplastic Agents; Dihydrotestosterone; Estradiol; Female; In Vitro Techniques; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Estradiol; Receptors, Steroid | 1990 |
Specific patterns of oncogene activation in transplacentally induced tumors.
Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA, Neoplasm; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, ras; Maternal-Fetal Exchange; Methylnitrosourea; Mice; Molecular Sequence Data; Neoplasms, Experimental; Oligonucleotide Probes; Oncogenes; Placenta; Polymerase Chain Reaction; Pregnancy; Rats; Rats, Inbred BUF; Transfection | 1990 |
Influence of hormonal disturbances on transplacental and multigeneration carcinogenesis in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Estrus; Female; Male; Methylnitrosourea; Methylthiouracil; Neoplasms, Experimental; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Thyroid Hormones; Thyroidectomy; Thyroxine | 1989 |
Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2'-dimethyl-4-aminobiphenyl, 2,2'-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea.
Topics: Aminobiphenyl Compounds; Animals; Body Weight; Butylated Hydroxyanisole; Carcinogens; Hyperplasia; Kidney; Liver; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Stomach Neoplasms; Tongue Neoplasms; Urinary Bladder Neoplasms | 1989 |
[The pharmacokinetics of the antitumor preparation of dimetinur].
Topics: Animals; Antineoplastic Agents; Colorimetry; Half-Life; Methylnitrosourea; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Time Factors; Tissue Distribution | 1989 |
General models for the generation and suppression of malignancy.
Topics: Animals; Chromosome Aberrations; Clone Cells; Gene Amplification; Gene Expression Regulation; Genes, Dominant; Genes, Recessive; Genetic Markers; Karyotyping; Lymphoma; Methylnitrosourea; Mice; Models, Genetic; Mutation; Neoplasms, Experimental; Oncogenes; Proto-Oncogenes; Suppression, Genetic | 1989 |
Morphological transformation of immortalized hamster dermal fibroblasts following treatment with simple alkylating carcinogens.
Topics: Alkylating Agents; Animals; Cell Division; Cell Transformation, Neoplastic; Cricetinae; DNA; DNA Damage; Ethylnitrosourea; Genes, ras; Methylnitrosourea; Mice; Mice, Nude; Neoplasms, Experimental; Sulfuric Acid Esters | 1988 |
Modulation of chemical carcinogenesis in rats by alkyl lysophospholipids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Leukemia, Experimental; Lysophospholipids; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Organophosphates; Organophosphorus Compounds; Phospholipid Ethers; Rats; Rats, Inbred Strains | 1987 |
[The effect of disorders of the estrous function in female rats on the realization of multigenerational carcinogenic effect of N-nitrosomethylurea].
Topics: Animals; Cocarcinogenesis; Estrus; Female; Methylnitrosourea; Neoplasms, Experimental; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1988 |
Carcinogenicity and organ specificity of N-trimethylsilylmethyl-N-nitrosourea (TMS-MNU), N-neopentyl-N-nitrosourea (neoPNU), and N-methyl-N-nitrosourea (MNU) in rats.
Topics: Animals; Carcinogens; Female; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Organ Specificity; Rats; Rats, Inbred F344; Silicon; Structure-Activity Relationship; Trimethylsilyl Compounds | 1988 |
Effect of age on dose-response relationship in carcinogenesis induced by single administration of N-nitrosomethylurea in female rats.
Topics: Age Factors; Alkylation; Animals; DNA; DNA Repair; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Species Specificity | 1988 |
[Comparative evaluation of the antitumor, cytogenetic and immunodepressive effects of dimetinur when used perorally and parenterally].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Chromosome Aberrations; Drug Evaluation, Preclinical; Immunity, Cellular; Immunosuppressive Agents; Injections, Intraperitoneal; Metaphase; Methylnitrosourea; Mice; Mice, Inbred Strains; Mutagens; Neoplasms, Experimental; Rats | 1988 |
N-methyl-N-nitrosourea-induced transformation of rat urothelial cells in vitro is not mediated by activation of ras oncogenes.
Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Epithelium; Gene Expression Regulation; Genes, ras; Intermediate Filaments; Methylnitrosourea; Mice; Mice, Nude; Molecular Sequence Data; Mutation; Neoplasms, Experimental; Rabbits; Transcriptional Activation; Urinary Bladder | 1987 |
Neoplasms of the skin and other organs observed in Swiss mice treated with nitrosoalkylureas.
Topics: Administration, Topical; Alkylation; Animals; Female; Lung Neoplasms; Methylnitrosourea; Mice; Neoplasms, Experimental; Skin Neoplasms | 1988 |
The effects of saccharin on the development of neoplastic lesions initiated with n-methyl-n-nitrosourea.
Topics: Animals; Drug Interactions; Methylnitrosourea; Mice; Neoplasms, Experimental; Saccharin | 1988 |
[Effect of pregnancy and lactation on the appearance of the carcinogenic action of N-methyl-N-nitrosourea in rats].
Topics: Animals; Female; Lactation; Male; Methylnitrosourea; Neoplasms, Experimental; Pregnancy; Pregnancy, Animal; Rats; Time Factors | 1987 |
Chemotherapy-induced malignancies in rats after treatment with cisplatin as single agent and in combination: preliminary results.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Gastrointestinal Neoplasms; Leukemia, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Sarcoma, Experimental | 1986 |
Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Chamomile; Female; Flavonoids; Indoles; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred Strains; Mutagens; Mutation; Neoplasms, Experimental; Oils, Volatile; Ornithine Decarboxylase; Plant Extracts; Plants, Medicinal; Skin; Tetradecanoylphorbol Acetate | 1986 |
[Effect of disordered thyroid function on the realization of the transplacental carcinogenic action of N-nitrosomethylurea in 1st- and 2d-generation rats].
Topics: Animals; Female; Methylnitrosourea; Methylthiouracil; Neoplasms, Experimental; Placenta; Pregnancy; Rats; Thyroid Gland; Thyroidectomy; Thyroxine | 1986 |
[Effectiveness of nitrosomethylurea derivatives in the combined chemotherapy of experimental tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation, Preclinical; Leukemia, Experimental; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental | 1986 |
[Dependence of the carcinogenic effect of N-nitrosomethylurea on its dosage and the age of female rats].
Topics: Aging; Animals; Dose-Response Relationship, Drug; Female; Methylnitrosourea; Neoplasms, Experimental; Rats; Time Factors | 1987 |
Influence of perinatal nicotine administration on transplacental carcinogenesis in Sprague Dawley rats by N-methylnitrosourea.
Topics: Animals; Female; Male; Mammary Neoplasms, Experimental; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nervous System Neoplasms; Nicotine; Pregnancy; Rats; Rats, Inbred Strains | 1987 |
Standardized tumor rates for chronic bioassays.
Topics: Animals; Carcinogens; Drug Evaluation, Preclinical; Female; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Risk; Urinary Bladder Neoplasms | 1986 |
Synthesis, toxicity, and therapeutic efficacy of 4-amino-N-(2'-aminophenyl)-benzamide: a new compound preferentially active in slowly growing tumors.
Topics: Animals; Antineoplastic Agents; Cell Line; Dimethylnitrosamine; Dogs; Drug Evaluation, Preclinical; Female; Lethal Dose 50; Male; Methylnitrosourea; Mice; Mutagenicity Tests; Neoplasms, Experimental; Phenylenediamines; Rats; Rats, Inbred Strains; Time Factors | 1985 |
[Data on the tumor-inducing effect of N-methyl-N-nitrosourea].
Topics: Animals; Cricetinae; Hemangioma, Cavernous; Mesocricetus; Methylnitrosourea; Mouth Neoplasms; Neoplasms, Experimental; Nitrosourea Compounds; Odontoma | 1985 |
Changes in de novo DNA (cytosine-5-)-methyltransferase activity in oncogenically susceptible rat target tissues induced by N-methyl-N-nitrosourea.
Topics: Animals; Brain; DNA (Cytosine-5-)-Methyltransferases; Kidney; Liver; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Spleen; Time Factors | 1986 |
Organ-specific carcinogenicity of N-methyl-N-nitrosourea in F344 and ACI/N rats.
Topics: Animals; Brain Neoplasms; Ethylnitrosourea; Female; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Organ Specificity; Rats; Rats, Inbred ACI; Rats, Inbred F344; Species Specificity; Spinal Cord Neoplasms | 1985 |
[Modifying effect of thyroid gland functional disorders on realization of transplacental carcinogenesis induced by N-nitrosomethylurea in rats].
Topics: Animals; Brain Neoplasms; Female; Maternal-Fetal Exchange; Methylnitrosourea; Methylthiouracil; Neoplasms, Experimental; Pregnancy; Rats; Thyroid Gland; Thyroid Neoplasms; Thyroidectomy; Thyroxine | 1985 |
[Effect of glucose on fetal weight and the transplacental blastomogenic effect of N-nitrosomethylurea in rats].
Topics: Animals; Birth Weight; Cocarcinogenesis; Female; Glucose; Male; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Pregnancy; Rats | 1985 |
Cell proliferation and DNA repair in the liver during early stages of chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Cycle; Cell Division; Clone Cells; DNA Repair; Guanine; Liver; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Phosphoglycerate Kinase; Precancerous Conditions; Rats; Rats, Inbred Strains; X Chromosome | 1985 |
N,N'-dimethylnitrosourea-induced tumors in mice and Syrian hamsters.
Topics: Animals; Cricetinae; Female; Injections, Subcutaneous; Lung Neoplasms; Lymphoma; Male; Mammary Neoplasms, Experimental; Mediastinal Neoplasms; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Retroviridae; Stomach Neoplasms; Thymus Neoplasms; Transplantation, Homologous | 1974 |
[Lysosomal enzymes in nitrosamine induced nervous system tumors of rats (author's transl)].
Topics: Acid Phosphatase; Animals; Brain; Brain Neoplasms; Ethylnitrosourea; Female; Glioma; Glucuronidase; Hexosaminidases; Lysosomes; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Oligodendroglioma; Pregnancy; Rats; Sulfatases | 1974 |
Induction of malignant lymphomas by N,N'-dimethylnitrosourea in adult mice.
Topics: Animals; Carcinogens; Female; Lymphatic Metastasis; Lymphoma; Male; Methylation; Methylnitrosourea; Mice; Microscopy, Electron; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Thymus Neoplasms; Urea | 1971 |