methylnitrosourea has been researched along with Experimental Hepatoma in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (32.65) | 18.7374 |
| 1990's | 24 (48.98) | 18.2507 |
| 2000's | 4 (8.16) | 29.6817 |
| 2010's | 5 (10.20) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aruoma, OI; Bahorun, T; Kumar, A; Singh, RK; Verma, S | 1 |
| Duarte, JA; Faustino-Rocha, AI; Ferreira, R; Oliveira, PA; Seixas, F; Talhada, D; Teixeira-Guedes, CI | 1 |
| Drinkwater, NR; Hanes, MA; Herbert, DC; Herzig, MC; Hildreth, K; McMahan, CA; Reddick, RL; Reddick, T; Street, K; Walter, CA; Zavadil, JA | 1 |
| Aruoma, OI; Bahorun, T; Bourdon, E; Kumar, A; Ramsaha, S; Sharma, P; Singh, RK; Somanah, J; Verma, S | 1 |
| Cho, WS; Choi, M; Han, BS; Jeong, J; Park, SN; Son, WC | 1 |
| Kramer, PM; Li, Y; Pereira, MA; Tao, L; Wang, W | 1 |
| Columbano, A; Rajalakshmi, S; Sarma, DS | 1 |
| Laval, F; Laval, J | 1 |
| Abakumova, OIu; Kutsenko, NG | 1 |
| Cayama, E; Farber, E; Sarma, DS; Solt, DB | 1 |
| Avakian, KA; Krugliakova, KE; Smotriaeva, MA; Zhizhina, GP | 1 |
| Allay, E; Dumenco, LL; Fan, CY; Gerson, SL; Liu, L; O'Connor, PJ; Zaidi, NH | 1 |
| Aresta, A; Farber, E; Kanduc, D | 1 |
| Luckert, PH; Pollard, M; Scheu, J | 1 |
| Akagi, K; Hirose, M; Hoshiya, T; Ito, N; Mizoguchi, Y; Shirai, T | 1 |
| Griffiths, JR; Howe, FA; Jeong, KS; Rodrigues, L; Stubbs, M; Veech, RL; Wang, J | 1 |
| Jungblut, PR; Otto, A; Rabes, HM; Zeindl-Eberhart, E | 1 |
| Laval, F; Lefebvre, P | 1 |
| Boonyaphiphat, P; Cabral, R; Hakoi, K; Hasegawa, R; Hoshiya, T; Ito, N; Ogiso, T; Shirai, T | 1 |
| Pereira, MA; Phelps, JB | 1 |
| Ahn, B; Han, BS; Hasegawa, R; Ito, N; Kim, DJ; Shirai, T; Tsuda, H | 1 |
| Kramer, PM; Li, K; Pereira, MA | 1 |
| Asamoto, M; Hirono, I; Hori, T; Iwahori, Y; Iwase, T; Kim, DJ; Matsumoto, K; Nagao, M; Nishida, Y; Takasuka, N; Tsuda, H; Ushijima, T | 1 |
| Archer, MC; Korkola, JE; Lee, VM; Sarma, DS; Wood, GA | 1 |
| Castonguay, A; Cloutier, JF | 1 |
| Asamoto, M; Kim, DJ; Kim, JM; Murakoshi, M; Nir, Z; Nishino, H; Ota, T; Sekine, K; Takasuka, N; Tsuda, H | 1 |
| Asakura, S; Daimon, H; Sagami, F; Sawada, S | 1 |
| Hirose, M; Shibutani, M; Shoda, T; Takada, K; Takahashi, M; Tamura, T; Toyoda, K; Uneyama, C | 1 |
| Kramer, PM; Pereira, MA; Tao, L; Xie, M; Yang, S | 1 |
| Kim, DJ; Nishino, H; Takasuka, N; Tsuda, H | 1 |
| Dimitrijevic, N; Jungblut, PR; Klugbauer, S; Lamer, S; Rabes, HM; Zeindl-Eberhart, E | 1 |
| Gorbacheva, LB; Kukushkina, GV; Sokolova, IS | 1 |
| Abakumova, OIu; Kutsenko, NG; Lerman, MI; Podobed, OV | 1 |
| Kamiya, S; Maekawa, A; Miyahara, M; Odashima, S | 1 |
| Rabes, HM; Zeindl-Eberhart, E | 1 |
| Bae, JH; Cho, KJ; Jang, JJ; Lee, YS | 2 |
| Ostermayr, R; Rabes, HM; Suchy, B | 1 |
| Fukushima, S; Hirose, M; Ito, N; Kato, T; Shibata, MA; Tatematsu, M | 1 |
| Cui, LX; Kitagawa, T; Lee, GH; Li, H; Liu, J; Nomura, K; Ohtake, K | 1 |
| Ogawa, K; Sakai, H | 1 |
| Kerler, R; Rabes, HM; Sarafoff, M; Suchy, BK | 1 |
| Maguire, S; Rabes, HM | 1 |
| Farber, E; Hayes, MA; Roberts, E | 1 |
| Asamoto, M; Inoue, K; Inui, M; Ito, N; Kagawa, M; Tsuda, H; Uwagawa, S | 1 |
| Columbano, A; Coni, P; Ledda-Columbano, GM; Pani, P | 1 |
| Devor, D; Kaufman, DG; Kaufmann, WK; Rice, JM; Wenk, ML | 1 |
| Diwan, BA; Ohshima, M; Palmer, AE; Rice, JM | 1 |
| Boiteux, S; Laval, F | 1 |
49 other study(ies) available for methylnitrosourea and Experimental Hepatoma
| Article | Year |
|---|---|
Effect of Aegle marmelos leaf extract on N-methyl N-nitrosourea-induced hepatocarcinogensis in Balb/c mice.
Topics: Aegle; Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Cytokines; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Immunologic Factors; Inflammation Mediators; Injections, Intraperitoneal; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Time Factors | 2013 |
A liver schwannoma observed in a female Sprague-Dawley rat treated with MNU.
Topics: Animals; Female; Hernia, Diaphragmatic; Liver Neoplasms, Experimental; Methylnitrosourea; Neurilemmoma; Rats; Rats, Sprague-Dawley | 2014 |
DNA Alkylating Agent Protects Against Spontaneous Hepatocellular Carcinoma Regardless of O6-Methylguanine-DNA Methyltransferase Status.
Topics: Alkylating Agents; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Diethylnitrosamine; DNA Modification Methylases; DNA Repair Enzymes; Hepatocytes; Humans; Immunoenzyme Techniques; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Transgenic; Tumor Suppressor Proteins | 2016 |
Fermented papaya preparation modulates the progression of N-methyl-N-nitrosourea induced hepatocellular carcinoma in Balb/c mice.
Topics: Animals; Antioxidants; Blood Cell Count; Carica; Disease Progression; Fermentation; Fruit; Hemoglobins; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Plant Preparations | 2016 |
26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.
Topics: Adenoma, Liver Cell; Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens; Clofibrate; Diethylhexyl Phthalate; Disease Models, Animal; Female; Genes, ras; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Transgenic; Phthalic Acids; Pyrimidines; Time Factors | 2011 |
Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Topics: 5-Methylcytosine; Animals; Carcinogens; CpG Islands; Dichloroacetic Acid; DNA; DNA Methylation; Female; Immunohistochemistry; Insulin-Like Growth Factor II; Liver Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred Strains; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trichloroacetic Acid | 2004 |
Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures.
Topics: Animals; Cell Division; Diet; Dimethylhydrazines; gamma-Glutamyltransferase; Hepatectomy; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Precancerous Conditions; Rats; Time Factors | 1981 |
Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.
Topics: Acclimatization; Alkylating Agents; Animals; Cell Line; Cell Survival; Drug Resistance; Kinetics; Liver Neoplasms, Experimental; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Rats | 1984 |
[Synthesis of protein, RNA and DNA and alkylation of macromolecules in the cells of sensitive and resistant strains of ascites hepatoma 22a induced by N-methyl-N-nitrosourea].
Topics: Animals; DNA, Neoplasm; Drug Resistance; Kinetics; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Neoplasm Proteins; RNA, Neoplasm | 1981 |
Persistence of resistant putative preneoplastic hepatocytes induced by N-nitrosodiethylamine or N-methyl-N-nitrosourea.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Diethylnitrosamine; Drug Resistance; Hepatectomy; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Nitrosamines; Nitrosourea Compounds; Precancerous Conditions; Rats; Rats, Inbred F344; Time Factors | 1980 |
[Effect of N-methyl-N-nitrosourea on the DNA of normal and tumor cells].
Topics: Animals; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry; DNA; DNA, Neoplasm; Liver Neoplasms, Experimental; Methylnitrosourea; Mice; Nitrosourea Compounds; Nucleic Acid Conformation | 1980 |
Alkyltransferase transgenic mice: probes of chemical carcinogenesis.
Topics: Actins; Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogens; DNA Repair; Female; Gene Expression Regulation, Enzymologic; Immunoenzyme Techniques; Liver Neoplasms, Experimental; Lymphoma; Male; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; Models, Genetic; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Phosphoenolpyruvate Carboxykinase (GTP); Promoter Regions, Genetic; Thymus Neoplasms | 1994 |
Hypermethylation of replicating hepatic DNA following N-methyl-N-nitrosourea administration.
Topics: Animals; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Damage; DNA Replication; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Methylation; Methylnitrosourea; Mitogens; Rats; Rats, Wistar; Sensitivity and Specificity; Tritium | 1994 |
Phenobarbital promotes the development of adenocarcinomas in the accessory sex glands of MNU-inoculated L-W rats.
Topics: Abdominal Neoplasms; Adenocarcinoma; Adenoma; Aging; Animals; Carcinogens; Drug Implants; Genital Neoplasms, Male; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Peritoneal Neoplasms; Phenobarbital; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Seminal Vesicles; Testosterone | 1995 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylhydrazines; Drug Screening Assays, Antitumor; Ellagic Acid; Gastrointestinal Neoplasms; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Multiple Primary; Nitrosamines; Quercetin; Random Allocation; Rats; Rats, Inbred F344 | 1995 |
Metabolic consequences of a reversed pH gradient in rat tumors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Carbonates; Cell Membrane Permeability; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Liver; Liver Neoplasms, Experimental; Magnesium; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Experimental; Methylnitrosourea; NAD; Phosphorus; Potassium; Rats; Rats, Inbred BUF; Rats, Wistar; Sarcoma, Experimental; Sodium | 1994 |
Identification of tumor-associated protein variants during rat hepatocarcinogenesis. Aldose reductase.
Topics: Aldehyde Reductase; Amino Acid Sequence; Animals; Biomarkers, Tumor; Electrophoresis, Gel, Two-Dimensional; Genetic Variation; Lens, Crystalline; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Molecular Sequence Data; Neoplasm Proteins; Peptide Mapping; Rats; Rats, Wistar; Sequence Homology, Amino Acid; Vas Deferens | 1994 |
A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Death; Cell Division; CHO Cells; Cricetinae; DNA Damage; DNA Repair; Drug Hypersensitivity; Drug Resistance; Guanine; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Rats; Tumor Cells, Cultured | 1993 |
Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats.
Topics: Animals; Body Weight; Captan; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Models, Biological; Nitrosamines; Organ Size; Pesticides; Precancerous Conditions; Rats; Rats, Inbred F344; Zineb | 1993 |
Promotion by dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Dichloroacetic Acid; Drug Synergism; Eosine Yellowish-(YS); Female; Hematoxylin; Liver Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred Strains; Staining and Labeling; Trichloroacetic Acid | 1996 |
Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model.
Topics: Adenocarcinoma; Adenoma; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Drug Synergism; Indoles; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Sprague-Dawley; Thyroid Neoplasms | 1997 |
Promotion by mixtures of dichloroacetic acid and trichloroacetic acid of N-methyl-N-nitrosourea-initiated cancer in the liver of female B6C3F1 mice.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Dichloroacetic Acid; Drug Combinations; Female; Glutathione Transferase; Immunohistochemistry; Liver; Liver Neoplasms, Experimental; Methylnitrosourea; Mice; Organ Size; Time Factors; Trichloroacetic Acid; Water Pollutants, Chemical | 1997 |
Demonstration of ras and p53 gene mutations in carcinomas in the forestomach and intestine and soft tissue sarcomas induced by N-methyl-N-nitrosourea in the rat.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Genes, p53; Genes, ras; Intestinal Neoplasms; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Papilloma; Point Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred F344; Sarcoma, Experimental; Sequence Analysis, DNA; Stomach Neoplasms | 1997 |
Resistance of Copenhagen rats to chemical induction of glutathione S-transferase 7-7-positive liver foci.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Resistance; Enzyme Induction; Glutathione Transferase; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Species Specificity | 1997 |
Modulation of DNA repair by various inhibitors of DNA synthesis following 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced DNA damage.
Topics: Animals; Carcinogens; Cells, Cultured; DNA Damage; DNA Methylation; DNA Repair; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Nitrosamines; Nucleic Acid Synthesis Inhibitors; Pyridines; Rats; Rats, Inbred F344; Tobacco Smoke Pollution; Topoisomerase I Inhibitors | 1998 |
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carotenoids; Chemoprevention; Colonic Neoplasms; Diethylnitrosamine; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Lycopene; Male; Methylnitrosourea; Mice; Organ Size | 1997 |
A short-term assessment of tumor-promotion activity in the livers of rats treated with two genotoxic methylating agents: dimethylnitrosamine and methylnitrosourea.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Dimethylnitrosamine; DNA Replication; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344 | 1998 |
Tumor-promoting activities of hydroquinone and 1,1-dimethylhydrazine after initiation of newborn mice with 1-methyl-1-nitrosourea.
Topics: Adenoma; Animals; Animals, Newborn; Body Weight; Carcinogens; Carcinoma; Dimethylhydrazines; Female; Hydroquinones; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Mice; Mice, Inbred ICR; Mutagens; Organ Size | 1999 |
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Topics: Alkylating Agents; Animals; Blotting, Northern; Blotting, Southern; Blotting, Western; Dichloroacetic Acid; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Methylnitrosourea; Methyltransferases; Mice; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-myc; RNA, Messenger; Trichloroacetic Acid | 2000 |
Chemoprevention of lung cancer by lycopene.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Carotenoids; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Lycopene; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Sex Characteristics | 2000 |
Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants.
Topics: Aldehyde Reductase; Aldo-Keto Reductases; Amino Acid Sequence; Animals; Base Sequence; Carcinogens; Diethylnitrosamine; Electrophoresis, Gel, Two-Dimensional; Fetal Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Inactivation, Metabolic; Isoenzymes; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Molecular Sequence Data; Nafenopin; Neoplasm Proteins; Nitrosamines; Organ Specificity; Peroxisome Proliferators; Proteome; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subtraction Technique | 2001 |
[Kinetics of macromolecular carbamoylation in normal and tumor cells after the administration of N-methyl-N-nitrosourea-14CO].
Topics: Animals; Carbon Radioisotopes; DNA; DNA, Neoplasm; Drug Evaluation, Preclinical; Kinetics; Lipid Metabolism; Liver Neoplasms, Experimental; Macromolecular Substances; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasm Proteins; Neoplasm Transplantation; Nitrosourea Compounds; Proteins; RNA; RNA, Neoplasm | 1979 |
[Accelerated microsomal DNA synthesis under the influence of xenobiotics and chemical carcinogens].
Topics: Animals; Benzopyrenes; Caffeine; Cell Nucleus; Cycloheximide; DNA; DNA, Mitochondrial; DNA, Neoplasm; Hydroxyurea; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Puromycin; Stimulation, Chemical | 1979 |
Antitumor effect of pyridine N-oxides having 1-(2-chloroethyl)-1-nitrosoureidoalkyl and 1-methyl-1-nitrosoureidoalkyl groups.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Cyclic N-Oxides; Drug Evaluation, Preclinical; Leukemia L1210; Liver Neoplasms, Experimental; Methylnitrosourea; Mice; Nitrogen Mustard Compounds; Nitrosourea Compounds; Pyridines; Rats; Solubility; Time Factors | 1979 |
Variant protein patterns in hepatomas and transformed liver cell lines as determined by high resolution two-dimensional gel electrophoresis (2DE).
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Electrophoresis, Gel, Two-Dimensional; Glutathione Transferase; Hydroxyurea; Isoelectric Focusing; Isoenzymes; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Methylnitrosourea; Neoplasm Proteins; Precancerous Conditions; Proteins; Rats; Rats, Inbred Strains | 1992 |
Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
Topics: Animals; Capsaicin; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1991 |
Carcinogen-induced liver tumours of Wistar rats: absence of activated ras genes and of N-rasC.
Topics: Animals; Base Sequence; Blotting, Southern; Codon; Exons; Gene Expression Regulation; Genes, ras; Introns; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Molecular Sequence Data; Mutation; Rats; Rats, Inbred Strains | 1991 |
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Pepsinogens; Pylorus; Rats; Rats, Inbred F344; Stomach Neoplasms; Urinary Bladder Neoplasms | 1991 |
Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.
Topics: Animals; Codon; Genes, ras; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Methylnitrosourea; Mutation; Polymorphism, Restriction Fragment Length; Rats; Rats, Inbred F344; RNA, Messenger; Time Factors; Transfection | 1990 |
Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Topics: Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Disease Models, Animal; Germanium; Indoles; Kidney; Liver; Liver Neoplasms, Experimental; Lung; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Size; Rats; Rats, Inbred F344; Sulfides | 1991 |
Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats.
Topics: Animals; Diethylnitrosamine; Genes, ras; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mutation; Polymerase Chain Reaction; Rats; Rats, Inbred F344 | 1990 |
Amplification, rearrangements, and enhanced expression of c-myc in chemically induced rat liver tumors in vivo and in vitro.
Topics: Animals; Blotting, Northern; Blotting, Southern; Gene Amplification; Gene Expression Regulation, Neoplastic; Gene Rearrangement; In Vitro Techniques; Liver Neoplasms, Experimental; Lung Neoplasms; Methylnitrosourea; Phenobarbital; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Restriction Mapping; RNA, Neoplasm; Transcription, Genetic | 1989 |
Intralobular distribution of preneoplastic foci in rat liver after a single dose of N-methyl-N-nitrosourea (MNU) following partial hepatectomy.
Topics: Animals; Hepatectomy; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Precancerous Conditions; Rats; Rats, Inbred Strains | 1989 |
Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine.
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA; Drug Resistance; gamma-Glutamyltransferase; Hepatectomy; Liver Neoplasms, Experimental; Liver Regeneration; Male; Methylnitrosourea; Pyrrolizidine Alkaloids; Rats; Rats, Inbred F344 | 1985 |
Positive influence of dietary deoxycholic acid on development of pre-neoplastic lesions initiated by N-methyl-N-nitrosourea in rat liver.
Topics: Animals; Deoxycholic Acid; Diet; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Precancerous Conditions; Rats; Rats, Inbred F344 | 1988 |
Failure of mitogen-induced cell proliferation to achieve initiation of rat liver carcinogenesis.
Topics: Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; Hepatectomy; Lead; Liver Neoplasms; Liver Neoplasms, Experimental; Methylnitrosourea; Mitogens; Nitrates; Rats | 1987 |
Cell cycle-dependent initiation of hepatocarcinogenesis in rats by methyl(acetoxymethyl)nitrosamine.
Topics: Animals; Carcinogens; Cell Cycle; Cell Division; Dimethylnitrosamine; DNA Repair; DNA Replication; Guanine; Hepatectomy; Hydrocortisone; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Time Factors | 1987 |
N-Nitroso-N-methylurea initiation in multiple tissues for organ-specific tumor promotion in rats by phenobarbital.
Topics: Animals; Body Weight; Carcinogens; Female; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Organ Size; Organ Specificity; Phenobarbital; Rats; Rats, Inbred F344; Sex Factors; Thyroid Neoplasms | 1985 |
Repair of O6-methylguanine, by mammalian cell extracts, in alkylated DNA and poly(dG-m5dC).(poly dG-m5dC) in B and Z forms.
Topics: Alkylation; Animals; DNA Repair; Guanine; Liver Neoplasms, Experimental; Methylnitrosourea; Methyltransferases; Nucleic Acid Conformation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1985 |