methylnitrosourea has been researched along with Disease Models, Animal in 239 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (14.23) | 18.7374 |
| 1990's | 42 (17.57) | 18.2507 |
| 2000's | 69 (28.87) | 29.6817 |
| 2010's | 81 (33.89) | 24.3611 |
| 2020's | 13 (5.44) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, J; Cha, S; Choi, KE; Goo, YS; Jeong, Y; Kim, SW; Yoo, M | 1 |
| Colaco, B; DA Costa, RMG; Fardilha, M; Faustino-Rocha, AI; Ferreira, R; Moreira-Goncalves, D; Nascimento-Goncalves, E; Neuparth, MJ; Oliveira, PA; Pires, MJ; Seixas, F | 1 |
| Arima, M; Fujii, Y; Murakami, Y; Sonoda, KH | 1 |
| Chen, L; Fang, D; Feng, L; Li, P; Liang, J; Wei, P; Xie, T; Yao, F; Zhang, S; Zhuang, Y; Zou, Z | 1 |
| Chen, W; He, M; Ma, Z; Peng, G; Qu, Y; Tao, Y; Teng, D; Yang, Q | 1 |
| Sun, H; Tao, Y; Xu, L; Yu, H; Yu, X | 1 |
| Jung, E; Jung, WK; Kim, HR; Kim, J; Park, SB | 1 |
| Ezaki, T; Fujieda, H; Hayakawa, R; Kawakami, H; Kitahara, S; Komoike, K; Morishima, M; Shimizu, K | 1 |
| Chen, G; Chen, M; Chen, T; Long, P; Wang, J; Wei, D; Yan, W; Zhang, Z; Zheng, X | 1 |
| Chen, J; Dong, Y; Huang, Y; Li, R; Li, X; Qu, Y; Tao, Y; Wang, L; Xiao, W; Yang, Q; Zheng, S | 1 |
| Bao, LH; Chen, T; Deng, CL; Hu, CB; Hu, CH; Ling, ST; Sui, BD; Xiong, YC; Yu, XR; Zhao, N; Zhou, F | 1 |
| Ahn, J; Anh, VTQ; Cha, S; Choi, KE; Goo, YS; Kim, JT; Kim, SW; Yun, C | 1 |
| Du, E; Li, H; Li, M; Song, Z; Tao, Y; Wang, Y; Wei, Y; Yang, G; Zhang, Q | 1 |
| Zhou, G; Zhou, Y | 1 |
| Diao, Y; Fang, Y; Huang, Y; Li, Q; Li, R; Li, X; Qu, Y; Tao, Y; Wang, J; Wang, L; Yang, Q | 1 |
| Ji, J; Jiang, Y; Liu, X; Qi, X; Ren, J; Yu, Y; Zhang, J; Zhu, Z | 1 |
| Fang, M; Kang, HG; Ohman Strickland, PA; Zarbl, H | 1 |
| Balmer, JM; Enzmann, V; Reisenhofer, MH | 1 |
| Gonçalves, BF; Maldonado, CA; Quintar, AA; Taboga, SR | 1 |
| Fan, C; Gu, W; Li, B; Liu, S; Lyu, J; Wang, C; Wu, X; Yang, Y; Zhou, S; Zuo, Q | 1 |
| Fang, W; Gao, Y; Huang, YF; Liu, B; Ma, Z; Qin, L; Tao, Y; Wang, L | 1 |
| Chen, Y; Liu, S; Luo, X; Shen, Y | 1 |
| Furukawa, A; Koriyama, Y; Sugitani, K | 1 |
| Ding, L; Gao, Y; Huang, YF; Li, Z; Qin, L; Tao, Y; Teng, D; Yang, Q; Yang, Z; Yao, A; Yu, L | 1 |
| Kaithwas, G; Pandey, R; Roy, S; Sammi, SR; Singh, M | 1 |
| Burbano, RR; DA Rocha, CAM; DE Assumpção, PP; DE Castro Sant' Anna, C; DE Fátima Aquino Moreira Nunes, C; DE Fátima Ferreira Borges DA Costa, J; Lamarão, LM; Muniz, JAPC | 1 |
| Barathidasan, R; Biswas, D; Mansingh, DP; Pradhan, S; Vasanthi, HR | 1 |
| Dong, X; Lu, X; Peng, G; Qu, Y; Tao, Y; Wang, C; Zhang, J | 1 |
| Mori, A; Niwa, T; Tatematsu, M; Toyoda, T; Tsukamoto, T; Ushijima, T | 1 |
| Akanuma, M; Hayakawa, Y; Hikiba, Y; Hirata, Y; Kinoshita, H; Koike, K; Maeda, S; Nakagawa, H; Nakata, W; Sakamoto, K; Sakitani, K; Serizawa, T; Shibata, W; Takahashi, R | 1 |
| Amorim, RL; de Campos, SG; Falleiros, LR; Góes, RM; Gonçalves, BF; Scarano, WR; Taboga, SR; Zanetoni, C | 1 |
| Gao, Y; Mäkelä, TP; Ristimäki, AP; Udd, L | 1 |
| Bae, S; Cho, K; Mabasa, L; Park, CS; Walters, MW | 1 |
| Chun, MH; Jeon, JH; Jeong, E; Jung, SW; Kim, HB; Kim, IB; Kim, M; Lee, SH; Paik, SS | 1 |
| Balmer, J; Enzmann, V; Iglicki, M; Jazwinska, A; Schuerch, K; Tappeiner, C; Tschopp, M | 1 |
| Carvalho, JR; Favaro, WJ; Felisbino, SL; Jeronimo, GD; Justulin, LA; Reis, MD; Sanches, LD; Santos, SA | 1 |
| Jiang, W; Matthews, SB; McGinley, JN; Neil, ES; Thompson, HJ; Zhu, Z | 1 |
| Chen, YY; Hu, DP; Liu, SL; Shen, Y; Xing, YQ | 1 |
| Johnen, S; Mataruga, A; Müller, F; Pfarrer, C; Rösch, S; Walter, P | 1 |
| Kato, S; Koriyama, Y; Ogai, K; Sugitani, K | 1 |
| Billis, A; Fávaro, WJ; Ferrari, K; Reis, LO; Rocha, GZ; Zamuner, M | 1 |
| Do, SH; Lee, HR; Lim, HK | 1 |
| Adamicová, K; Adamkov, M; Bojková, B; Chmelová, M; Kajo, K; Kapinová, A; Kassayová, M; Kružliak, P; Kubatka, P; Orendáš, P; Péč, M; Sadloňová, V; Stollárová, N; Výbohová, D | 1 |
| Budak, M; Kalkan, T; Korpinar, MA; Tuncel, H | 1 |
| Caicedo-Granados, E; Galbraith, AR; Hartle, DE; Keel, S; Ondrey, FG; Schachern, MG; Wattenberg, LW; Wuertz, BR; Yueh, B | 1 |
| Bennett, C; Bernard, PS; Bode, AM; Green, JE; Grubbs, CJ; Juliana, MM; Lubet, RA; McGovern, R; Moeinpour, F; Reid, JM; Steele, VE; Stijleman, IJ; Thompson, MD | 1 |
| Balmer, J; Enzmann, V; Reisenhofer, M; Zulliger, R | 1 |
| Adamkov, M; Bojková, B; Dobrota, D; Kajo, K; Kapinová, A; Kassayová, M; Kello, M; Kruzliak, P; Kubatka, P; Mahmood, S; Mojžiš, J; Murin, R; Péč, M; Stollárová, N; Viera, T; Výbohová, D; Zulli, A | 1 |
| Ahn, HR; Jung, SH; Kang, SW; Kim, KA; Song, Y; Yang, SJ | 1 |
| Adamkov, M; Bálentová, S; Bojková, B; Demečková, V; Kajo, K; Kružliak, P; Kubatka, P; Orendáš, P; Péč, M; Výbohová, D; Zulli, A | 1 |
| Hisano, S; Kato, S; Koriyama, Y; Ogai, K; Sugitani, K | 1 |
| Berriel, E; Bollati-Fogolín, M; Chiale, C; Chiribao, ML; Festari, MF; Freire, T; Mazal, D; Medeiros, A; Osinaga, E; Rabinovich, GA; Robello, C; Rondán, M; Ubillos, L | 1 |
| Imaoka, M; Iwata, N; Kimotsuki, T; Kinoshita, J; Maejima, T; Yasuda, M | 1 |
| Furukawa, A; Koriyama, Y | 1 |
| Emoto, Y; Kinoshita, Y; Kurokawa, I; Tsubura, A; Yoshizawa, K; Yuki, M; Yuri, T | 1 |
| Ernst, M; O'Donoghue, RJ; Poh, AR; Putoczki, TL | 1 |
| Elmore, SA; Emoto, Y; Kinoshita, Y; Shikata, N; Tsubura, A; Yoshizawa, K; Yuki, M; Yuri, T | 1 |
| Chen, T; Huang, YF; Liu, Z; Peng, G; Qin, L; Tao, Y; Xu, W | 1 |
| Deng, Y; Graidist, P; Hiransai, P; Sriwiriyajan, S; Tedasen, A | 1 |
| Dai, G; Gao, H; Peng, X; Wen, Y; Zhao, Q; Zhu, Y | 1 |
| Nandakumar, K; Nayak, PG; Ramalingayya, GV; Rao, CM; Shenoy, RR | 1 |
| Cao, R; Chen, T; Chen, X; Tao, Y; Xue, J; Yan, W; Yang, G; Zhang, L; Zhang, Z | 1 |
| Arnér, K; Ghosh, F; Taylor, L | 1 |
| Chen, T; Liu, ZY; Peng, GH; Qin, LM; Tao, Y; Wang, LQ; Xu, WW; Yi-Fei, H | 1 |
| Müller, F; Rösch, S; Walter, P; Werner, C | 1 |
| Cespedes Feliciano, E; De Jonghe, BC; Joshi, A; Leonard, JJ; Liu, Y; Malik, VS; Rosner, B; Schweitzer, A; Sturgeon, KM; Tobias, DK | 1 |
| Cho, H; Kim, YK; Moon, CH; Park, TK | 1 |
| Chang, HM; Cheng, YW; Chiou, GC; Ho, JD; Hsiao, G; Lin, CH; Lin, FL; Yen, JL | 1 |
| Chadha, VD; Dhawan, DK; Jan, G; Passi, ND | 1 |
| Lindgren, BR; Sinha, AA; Wilson, MJ | 1 |
| Machida, K; Nomura, T; Tsutsumi, H; Urano, K; Usui, T; Yoshimura, M | 1 |
| Cerar, A; Injac, R; Perse, M; Strukelj, B | 1 |
| Canpinar, H; Esendagli, G; Guc, D; Guc, MO; Gunel-Ozcan, A; Yilmaz, G | 1 |
| Boring, D; Grubbs, CJ; Juliana, MM; Lubet, RA; Ruppert, JM; Steele, VE | 1 |
| Hirami, Y; Homma, K; Jin, ZB; Mandai, M; Osakada, F; Takahashi, M | 1 |
| Cherukuri, P; Dhingra, NK; Jain, V; Krishnamoorthy, V; Nagar, S | 1 |
| Furihata, C; Kaminishi, M; Seto, Y; Shimizu, N; Tatematsu, M; Yamaguchi, H; Yamamoto, M; Yoshizawa, N | 1 |
| Maffini, MV; Murray, TJ; Sonnenschein, C; Soto, AM; Ucci, AA | 1 |
| Andrianakos, AG; Fleming-Elder, BK; Giles, ED; Gilman, KA; Jackman, MR; Johnson, GC; MacLean, PS; McDaniel, SM; Schedin, PJ; Shroyer, KR | 1 |
| Campos, SG; Góes, RM; Gonçalves, BF; Scarano, WR; Taboga, SR; Vilamaior, PS; Zanetoni, C | 1 |
| Long, GG; Morton, D; Peters, T; Short, B; Skydsgaard, M | 1 |
| Deng, XG; Gao, Y; Sun, QN; Zhong, ZQ | 1 |
| Bosland, MC; Johnson, WD; Lubet, RA; McCormick, DL; Rao, KV; Steele, VE | 1 |
| Cho, WS; Choi, M; Han, BS; Jeong, J; Park, SN; Son, WC | 1 |
| Billis, A; Cagnon, VH; Fávaro, WJ; Fazuoli, MG; Ferreira, U; Reis, LO | 1 |
| del Pilar Carrera, M; García, MJ; Martínez-Martos, JM; Mayas, MD; Ramírez-Expósito, MJ | 1 |
| Jiang, W; McTiernan, A; Thompson, HJ; Wolfe, P; Zhu, Z | 1 |
| Dai, H; Hua, Y; Shen, B; Xu, H; Zheng, L; Zhou, M | 1 |
| Betz, KS; Giraud, AS; Jin, G; Kawakami, K; Lerkowit, N; Menheniott, TR; Minamoto, T; Rio, MC; Shibata, W; Takaishi, S; Tomasetto, C; Tomita, H; Varro, A; Wang, TC; Yang, X | 1 |
| Błasiak, J; Cukrowska, B; Klewicka, E; Nowak, A; Zduńczyk, Z | 1 |
| Agawa, T; Goto, H; Kimura, K; Mishima, M; Tsukahara, R; Yamakawa, N; Yamauchi, Y | 1 |
| Andrade Junior, EF; Assumpção, PP; Burbano, RR; Calcagno, DQ; da Costa, Jde F; Demachki, S; Lacreta Junior, AC; Leal, MF; Muniz, JA; Rabenhorst, SH; Rezende, AP; Silva, TC; Smith, Mde A | 1 |
| Bhatia, S; Brueggemann, S; Cheng, B; Coburn, MA; Kleiner-Hancock, HE; Li, BD; Li, XL; Luraguiz, N; Mathis, JM; Maxuitenko, YY; Orchard, EA; Stoff-Khalili, MA; Zhang, S | 1 |
| Acar, N; Boudard, DL; Bretillon, L; Hicks, D | 1 |
| Chun, MH; Ha, TJ; Jeon, JH; Jeong, E; Jung, SW; Kang, S; Kim, IB; Paik, SS; Sim, S | 1 |
| Bisht, S; Chenna, V; Chun, YS; de Wilde, RF; Hong, SM; Huso, DL; Maitra, A; Pramanik, D; Rudek, MA; Stearns, V; Sukumar, S; Yoshida, T; Zhang, Z; Zhao, M | 1 |
| Harauma, A; Kuro, M; Moriguchi, T; Ohara, N; Sasaki, T; Takada, H; Tsubura, A; Uehara, N; Yoshizawa, K | 1 |
| Kagawa, N; Komada, M; Nagao, T | 1 |
| Ferrero, RL; Sutton, P; Wilson, JE | 1 |
| Aras, U; Gandhi, YA; Masso-Welch, PA; Morris, ME | 1 |
| Bahadir, GM; Berna, T; Berrak, Y; Can, E; Handan, K; Ipek, E; Umit, UM | 1 |
| Balasubramanian, MP; Jagadeesan, J; Nandakumar, N; Rengarajan, T | 1 |
| Jiang, W; McGinley, JN; Thompson, HJ; Zhu, Z | 1 |
| Anderson, AS; Eto, I; Grizzle, WE; Grubbs, CJ; Johanning, GL; Rodríguez-Burford, C; Steele, VE; Stockard, CR; Weiss, HL | 1 |
| Kiuchi, K; Moriguchi, K; Tsubura, A; Yoshizawa, K | 1 |
| Cho, SW; Hahm, KB; Han, SU; Kim, DY; Kim, JH; Kim, MW; Kim, YB; Lee, JS; Nahm, KT; Oh, TY; Song, YJ; Surh, YJ; Yoo, BM | 1 |
| Cagatay, P; Kalkan, MT; Shimamoto, F; Tuncel, H | 1 |
| Ikehara, Y; Inada, K; Inoue, M; Kaminishi, M; Kumagai, T; Nozaki, K; Shimizu, N; Tanaka, H; Tatematsu, M; Tsukamoto, T | 1 |
| Cotter, TG; Donovan, M; Doonan, F | 1 |
| Boileau, TW; Clinton, SK; Erdman, JW; Kim, S; Lemeshow, S; Liao, Z | 1 |
| Baranova, M; Brtko, J; Galbavy, S; Liska, J; Macejova, D; Mostbock, S; Scheiblhofer, S; Stvrtina, S; Thalhamer, J; Weiss, R; Zlatos, J | 1 |
| Bohlmann, R; Gieschen, H; Heinrich, N; Hoffmann, J; Hofmeister, H; Kroll, J; Künzer, H; Lichtner, RB; Nishino, Y; Parczyk, K; Sauer, G; Schneider, MR; Ulbrich, HF | 1 |
| Singh, M; Thompson, HJ | 1 |
| Barder, T; Getzenberg, RH; Konety, BR; Myers, J; Van Le, TS | 1 |
| Anegón, I; Bausero, M; Hill, M; Khalife, J; Mazal, D; Ménoret, S; Osinaga, E | 1 |
| Estensen, RD; Wattenberg, LW; Wiedmann, TS | 1 |
| Krämer, K; Limpens, J; Obermüller-Jevic, UC; Pallapies, D; Schröder, FH; van Weerden, WM | 1 |
| Carrera, MP; García, MJ; Martínez-Martos, JM; Mayas, MD; Ramírez-Expósito, MJ; Valenzuela, MT | 1 |
| Charbonneau, M; Cole, J; Desaulniers, D; Leingartner, K; Li, M; Musicki, B; Tsang, BK | 1 |
| Boileau, TW; Clinton, SK; Erdman, JW; Liao, Z; Wang, S | 1 |
| Pollard, M; Suckow, MA; Wolter, W | 1 |
| Mizoshita, T; Tatematsu, M; Tsukamoto, T | 1 |
| Arab, K; Bougnoux, P; Colas, S; Germain, E; Goupille, C; Maheo, K | 1 |
| Badger, TM; Chatman, L; Eason, RR; Geng, Y; Korourian, S; Simmen, RC; Till, SR; Velarde, MC | 1 |
| Tsubura, A; Yoshizawa, K | 1 |
| Bergoc, R; Carbone, V; Cocca, C; Croci, M; Gutiérrez, A; Kleiman de Pisarev, DL; Nuñez, M; Randi, AS | 1 |
| Cho, YM; Hasumura, M; Hirose, M; Imai, T | 1 |
| Aceves, C; García-Solís, P | 1 |
| Ding, H; Feugang, JM; Qian, L; Shao, P; Wang, X; Wu, S; Yang, J; Zhou, J; Zou, C | 1 |
| Barbisan, LF; Bidinotto, LT; Rocha, NS; Salvadori, DM; Spinardi-Barbisan, AL | 1 |
| Fabian, CJ; Kimler, BF; Petroff, BK; Ting, AY | 1 |
| Barotto, NN; Bongiovanni, GA; Díaz, MP; Eynard, AR; Valentich, MA | 1 |
| Eguchi, N; Fukasawa, K; Kikuchi, K; Machida, K; Sawa, N; Suzuki, S; Taguchi, F; Urano, K; Usui, T | 1 |
| Pollard, M; Suckow, MA | 1 |
| Goss, PE; Hu, H; Qi, S; Strasser-Weippl, K | 1 |
| Akinaga, S; Anazawa, H; Ishida, H; Kuwabara, T; Li, PK; Murakata, C; Nakata, T; Sato, N; Shiotsu, Y; Suzuki, M; Takebayashi, M; Tanaka, H; Terasaki, Y | 1 |
| Chan, MM; Iglehart, JD; Lu, X; Merchant, FM; Miron, PL | 1 |
| Fukuda, Y; Hori, K; Kawazoe, T; Matsumoto, T; Miwa, H; Nakajima, K; Sakagami, T | 1 |
| Chen, J; Nathans, J | 1 |
| Anderson, WR; Estensen, RD; Galbraith, AR; Hartle, DE; Jordan, MM; Ondrey, FG; Wattenberg, LW | 1 |
| Akimoto, M; Imai, H; Mandai, M; Suzuki, T; Swaroop, A; Takahashi, M; Ueda, Y; Yoshimura, N | 1 |
| Aydin, A; Erbil, MK; Karayilanoglu, T; Kenar, L; Kose, S; Serdar, M | 1 |
| Bisson, JF; Guardia-Llorens, MA; Hidalgo, S; Messaoudi, M; Rozan, P | 1 |
| Baloni, S; Cherukuri, P; Dhingra, NK; Jain, V; Krishnamoorthy, V | 1 |
| Kachi, S; Kaneko, H; Nakamura, M; Nishiguchi, KM; Terasaki, H | 1 |
| Jänisch, W; Schmidt, T | 1 |
| Benfield, JR; Cohen, AH; Fu, PC; Hammond, WG; Jensen, T; Pak, HY; Paladugu, RR; Shors, EC; Teplitz, RL | 1 |
| Gusterson, BA; Williams, JC | 1 |
| Becci, PJ; Grubbs, CJ; Moon, RC; Thompson, HJ | 2 |
| Edwards, MB; Germain, JP | 2 |
| Matsumoto, S; Sato, H; Sato, N; Tamaki, N | 1 |
| Babaya, K; Miyata, Y; Oyasu, R | 1 |
| Cohen, MB; Heidger, PM; Lubaroff, DM | 1 |
| Itoh, N; Mori, H; Morishita, S; Murase, T; Niwa, K; Tamaya, T; Tanaka, T | 1 |
| Furmanski, P; Kantorowitz, DA; Thompson, HJ | 1 |
| Fukaura, Y; Ishikawa, C; Isoda, Y; Narisawa, T; Nishizawa, Y; Yazawa, K | 1 |
| Hayashi, Y; Imazawa, T; Maekawa, A; Mitsumori, K; Okeda, R; Onodera, H; Shibutani, M; Yoshida, J | 1 |
| Fukami, H; Iwata, H; Masui, T; Nakanishi, H; Tatematsu, M; Tezuka, N; Yamamoto, M; Yuasa, H | 1 |
| Ishikawa, T; Nakamura, T; Nakatsuru, Y; Oda, H; Qin, X; Shamsuddin, AM; Zarkovic, M | 1 |
| Katsuki, M | 1 |
| Fukushima, S; Futakuchi, M; Hirose, M; Ito, N; Takahashi, S; Tanaka, H | 1 |
| Chen, Y; McKenzie, K; Sukumar, S | 1 |
| Guzman, RC; Hwang, SI; Nandi, S; Swanson, SM | 1 |
| Russo, IH; Russo, J | 2 |
| Parkhouse, WS; Whittal, KS | 1 |
| Fukami, H; Ikeno, T; Kaminishi, M; Oohara, T; Shimizu, N; Sugiyama, A; Tatematsu, M; Yamamoto, M; Yoshikawa, A | 1 |
| Ikeno, T; Ishida, K; Katsuyama, T; Kawasaki, S; Maruta, F; Shimizu, N; Sugiyama, A; Tatematsu, M | 1 |
| Dahiya, R; Lee, C; Thompson, HJ; Zhu, Z | 1 |
| Göğüş, O; Ozdiler, E; Sözen, S; Yaman, O | 1 |
| Bosland, MC | 2 |
| Furihata, C; Ikehara, Y; Inada, K; Kobayashi, K; Tatematsu, M; Tsukamoto, T; Yamamoto, M | 1 |
| Chen, J; Rickard, SE; Thompson, LU; Yuan, YV | 1 |
| Cohen, LA; Lubet, R; Pittman, B; Zhao, Z | 1 |
| Grimm, C; Hafezi, F; Kueng-Hitz, N; Marti, A; Niemeyer, G; Remé, CE; Wenzel, A | 1 |
| Pollard, M; Sun, L; Wolter, WR | 1 |
| Cui, L; Futakuchi, M; Imaida, K; Kato, K; Shirai, T; Takahashi, S; Tamano, S | 1 |
| Belobrajdic, DP; McIntosh, GH | 1 |
| Nozaki, K; Shimizu, N; Tatematsu, M | 2 |
| Bouffler, SD; Cox, R; Fodde, R; Hofland, N | 1 |
| Chen, BQ; Wang, GJ; Zhou, SB; Zhu, Y | 1 |
| Albinescu, D; Christov, K; Hawthorne, M; Mehta, R; Moriarty, R; Uselding, L | 1 |
| Khachik, F; Masuda, M; Murakoshi, M; Narisawa, T; Nishino, H; Okuda, M; Onozuka, M; Satomi, Y; Takasuka, N; Takayasu, J; Tokuda, H; Tsuruta, J; Yamaguchi, S; Yano, M | 1 |
| Genta, RM; Katsuyama, T; Kawasaki, S; Maruta, F; Ota, H; Sugiyama, A; Tatematsu, M | 1 |
| Adcock, I; Ali, S; Coombes, RC; Ito, K; Mirsaidi, N; Pace, PE; Vigushin, DM | 1 |
| Mori, H; Niwa, K; Sakata, K; Yamada, Y; Yoshimi, N; Zheng, Q | 1 |
| Fukuda, Y; Hori, K; Kobayashi, T; Koizuka, H; Nakamura, Y; Sakagami, T; Shimoyama, T; Tanida, N; Yamamoto, N; Yokota, Y | 1 |
| Anderson, MB; Bischoff, ED; Cheng, Q; Dai, J; Dwived, PD; Hill, SM; Kiefer, TL; Lai, L; Melancon, K; Moro, K; Nowfar, S; Teplitzky, SR; Yuan, L | 1 |
| Kiuchi, K; Matsumura, M; Shikata, N; Tsubura, A; Yoshizawa, K | 1 |
| Swanson, SM; Unterman, TG | 1 |
| Conneely, OM; Gay, J; Hilsenbeck, SG; Medina, D; O'Malley, BW; Shine, HD; Sivaraman, L | 1 |
| Swenberg, JA | 1 |
| Cravioto, H; Yoshida, J | 1 |
| Nettesheim, P; Yarita, T | 1 |
| Becci, PJ; Grubbs, CJ; Moon, RC; Norikane, K; Thompson, HJ | 1 |
| Battaglino, A; Gagnon, HJ; Yerganian, G | 1 |
| Hirao, Y; Iwasaki, T; Matsumoto, M; Oyasu, R; Tabuchi, Y | 1 |
| Bates, RR | 1 |
| Martino, C; Soloway, MS | 1 |
| Alexandrov, VA | 1 |
| Rupprecht, E; Rupprecnt, U; Schneider, J; Thust, R; Warzok, R | 1 |
| Benfield, JR; Cohen, AH; Matsumura, K; Okita, M; Shors, EC | 1 |
| Axler, DA; Denlinger, RH; Koestner, A; Liss, L | 1 |
| Rao, MS; Reddy, JK | 1 |
| Corbett, TH; Griswold, DP; Peckham, JC; Roberts, BJ; Schabel, FM | 1 |
| Maronpot, R; Narisawa, T; Reddy, BS; Weisburger, JH; Wynder, EL | 1 |
| Corbett, TH; Griswold, DP | 1 |
| Pollard, M | 1 |
| Kawaura, A; Oda, M; Sawada, K; Shimoyama, T; Tanida, T | 1 |
| Chaudhuri, B; Chaudhuri, PK; Crist, KA; Shivaram, S | 1 |
| Detrisac, CJ; Kelloff, GJ; Moon, RC; Rao, KV | 1 |
| Hoshiya, T; Imaida, K; Ito, N; Kato, T; Ogawa, K; Shichino, Y; Tatematsu, M | 1 |
| Furui, T; Mori, H; Niwa, K; Tamaya, T; Tanaka, T; Yokoyama, Y | 2 |
| Luckert, PH; Pollard, M | 2 |
| Charreau, EH; Lanari, C; Meiss, R; Pasqualini, CD; Pazos, P | 1 |
| Benfield, JR; Hammond, WG | 1 |
| Cohen, LA; Kendall, ME; Meschter, C; Rose, DP; Zang, E | 1 |
| Blask, DE; Grosso, DS; Hill, SM; Lemus-Wilson, A; Pelletier, DB; Wilson, ST; Wise, ME | 1 |
| Kovatch, RM; Lijinsky, W; Thomas, BJ | 1 |
| Fukushima, S; Hirose, M; Ito, N; Kato, T; Shibata, MA; Tatematsu, M | 1 |
| Bae, JH; Cho, KJ; Jang, JJ; Lee, YS | 1 |
| Fukushima, S; Ito, N; Shirai, T | 1 |
| Brendler, CB; Ichikawa, T; Isaacs, JT; Squire, RA; Steinberg, GD | 1 |
| Dohi, K; Ito, A; Mori, M; Naito, M; Takeichi, N; Watanabe, H | 1 |
| Hayashi, M; Hosotani, K; Ishii, Y; Ishimori, Y; Kabuto, M; Katsumura, H; Kobayashi, H; Kubota, T; Nakagawa, T | 1 |
| Cooke, CB; Smith, SB; Yielding, KL | 1 |
| Hawrylewicz, EJ | 1 |
| Broitman, SA | 1 |
| Jordan, VC | 1 |
| Talmadge, JE | 1 |
| Amberger, H | 1 |
| Smith, SB; Yielding, KL | 1 |
| Harris, CC | 1 |
28 review(s) available for methylnitrosourea and Disease Models, Animal
| Article | Year |
|---|---|
Appraising Animal Models of Prostate Cancer for Translational Research: Future Directions.
Topics: Animals; Disease Models, Animal; Humans; Male; Methylnitrosourea; Prostatic Neoplasms; Rats; Testosterone; Translational Research, Biomedical | 2023 |
What Can Pharmacological Models of Retinal Degeneration Tell Us?
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Humans; Iodates; Iodoacetic Acid; Methylnitrosourea; Pharmaceutical Preparations; Photoreceptor Cells, Vertebrate; Retina; Retinal Degeneration; Retinal Pigment Epithelium | 2017 |
[Role of Heat Shock Protein 70 in Retinitis Pigmentosa and a Novel Strategy for Treatment].
Topics: Animals; Calpain; Cell Death; Disease Models, Animal; HSP70 Heat-Shock Proteins; Humans; Methylnitrosourea; Retinitis Pigmentosa | 2015 |
Mouse models for gastric cancer: Matching models to biological questions.
Topics: Animals; Disease Models, Animal; Gastrins; Helicobacter felis; Helicobacter Infections; Helicobacter pylori; Methylnitrosourea; Mice, Inbred Strains; Mice, Transgenic; Molecular Targeted Therapy; Stomach Neoplasms | 2016 |
Alternative mouse models for carcinogenicity assessment: industry use and issues with pathology interpretation.
Topics: Animals; Carcinogenicity Tests; Disease Models, Animal; Genes, ras; Methylnitrosourea; Mice; Neoplasms, Experimental; Terminology as Topic; Tumor Suppressor Protein p53 | 2010 |
Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible?
Topics: Alanine; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cytokines; Disease Models, Animal; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitrosourea; Mice; NF-kappa B; Quinolones; Stomach Neoplasms; Sulfonamides | 2003 |
Rat models of premalignant breast disease.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; Disease Models, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Precancerous Conditions; Rats | 2000 |
Role of Helicobacter pylori in gastric carcinogenesis: the origin of gastric cancers and heterotopic proliferative glands in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Cocarcinogenesis; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Precancerous Conditions; Sodium Chloride, Dietary; Stem Cells; Stomach Neoplasms | 2005 |
[Characteristics of N-methyl-N-nitrosourea-induced retinal degeneration in animals and application for the therapy of human retinitis pigmentosa].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspases; Cricetinae; Disease Models, Animal; Docosahexaenoic Acids; Humans; Methylnitrosourea; Mice; Niacinamide; Oligopeptides; Photoreceptor Cells; Proto-Oncogene Proteins c-bcl-2; Rats; Retinal Degeneration; Retinitis Pigmentosa | 2005 |
[Study of nutritional factors related to breast cancer prevention. Importance of animal models approaches].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carotenoids; Diet; Diet, Carbohydrate-Restricted; Disease Models, Animal; Energy Intake; Fatty Acids; Female; Glycine max; Iodine; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Rats; Retinoids; Risk Factors; Seaweed | 2005 |
Dietary prevention of hormone refractory prostate cancer in Lobund-Wistar rats: a review of studies in a relevant animal model.
Topics: Animals; Diet; Disease Models, Animal; Drug Resistance, Neoplasm; Isoflavones; Male; Methylnitrosourea; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Rats; Rats, Wistar; Soybean Proteins; Testosterone | 2006 |
[Development of animal models for carcinogenesis by transgenesis. Transgenic mouse models for cancer research].
Topics: Animals; Disease Models, Animal; Genes, ras; Humans; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasms, Experimental; Transduction, Genetic | 1993 |
Animal models for breast cancer.
Topics: Animals; Cyclin D1; Cyclins; Disease Models, Animal; Female; Gene Amplification; Genes, p53; Genes, ras; Mammary Neoplasms, Experimental; Methylnitrosourea; Oncogene Proteins; Rats | 1995 |
Experimentally induced mammary tumors in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diet; Disease Models, Animal; Disease Progression; Disease Susceptibility; Female; Gonadal Steroid Hormones; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Radiation-Induced; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1996 |
Use of animal models in defining efficacy of chemoprevention agents against prostate cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma in Situ; Disease Models, Animal; Humans; Male; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasms, Experimental; Prostatic Neoplasms; Rats; Sensitivity and Specificity; Treatment Outcome | 1999 |
Experimental prostate carcinogenesis - rodent models.
Topics: Aminobiphenyl Compounds; Animals; Carcinogens; Disease Models, Animal; Imidazoles; Male; Methylnitrosourea; Mice; Mice, Transgenic; Nitrosamines; Prostatic Neoplasms; Rats; Rats, Inbred F344; Rats, Inbred Strains; Rats, Wistar | 2000 |
[Eradication model employing Mongolian gerbils treated with chemical carcinogen and infected with Helicobacter pylori--implications for human cancer prevention].
Topics: Adenocarcinoma; Animals; Carcinogens; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms | 2000 |
[The role of Helicobacter pylori infection and effect of eradication in experimental animal models of gastric carcinogenesis].
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Metaplasia; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms | 2001 |
Chemical- and virus-induced brain tumors.
Topics: Adenoviridae; Alkylation; Alpharetrovirus; Animals; Brain Neoplasms; Carcinogens; Disease Models, Animal; DNA, Neoplasm; Ethylnitrosourea; Humans; Methylnitrosourea; Neoplasms, Experimental; Oncogenic Viruses; Papillomaviridae; Polycyclic Compounds; Polyomaviridae; Retroviridae; Tumor Virus Infections | 1977 |
Chemical carcinogenesis and the pancreas.
Topics: 4-Hydroxyaminoquinoline-1-oxide; Adenocarcinoma; Adenoma; Aminoquinolines; Animals; Bile; Carcinogens; Carcinogens, Environmental; Dimethylnitrosamine; Disease Models, Animal; Duodenum; Humans; Liver; Methylnitrosourea; Nitrosamines; Nitrosomethylurethane; Organ Specificity; Pancreas; Pancreatic Ducts; Pancreatic Neoplasms; Precancerous Conditions; Stomach Neoplasms | 1975 |
The Lobund-Wistar rat model of prostate cancer.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Male; Methylnitrosourea; Precancerous Conditions; Prostatic Neoplasms; Rats; Rats, Wistar; Testosterone | 1992 |
Animal models for the study of prostate carcinogenesis.
Topics: Animals; Disease Models, Animal; Humans; Male; Methylnitrosourea; Prostatic Neoplasms; Rats; Testosterone | 1992 |
Mammary tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Cocarcinogenesis; Disease Models, Animal; Disease Susceptibility; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Hormone-Dependent; Precancerous Conditions | 1991 |
Fat-protein interaction, defined 2-generation studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Dietary Proteins; Disease Models, Animal; Eating; Epidemiologic Methods; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Prolactin; Thymidine | 1986 |
Cholesterol conundrums: the relationship between dietary and serum cholesterol in colon cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Animals; Azoxymethane; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Cocarcinogenesis; Colonic Neoplasms; Diagnosis-Related Groups; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Epidemiologic Methods; Humans; Methylnitronitrosoguanidine; Methylnitrosourea | 1986 |
Laboratory models of breast cancer to aid the elucidation of antiestrogen action.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Estrogen Antagonists; Estrogens; Mammary Neoplasms, Experimental; Methylnitrosourea; Prolactin; Receptors, Estrogen; Structure-Activity Relationship | 1987 |
Preclinical approaches to the development of effective immunotherapeutic protocols for the treatment of metastasis.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Immunotherapy; Interleukin-2; Killer Cells, Natural; Macrophage Activation; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasm Metastasis; Neoplasms, Radiation-Induced; Pyran Copolymer; Rats; Recombinant Proteins; Skin Neoplasms | 1986 |
Cause and prevention of lung cancer.
Topics: Animals; Asbestos; Benzopyrenes; Cricetinae; Disease Models, Animal; Humans; Lung Neoplasms; Methylnitrosourea; Neoplasms; Neoplasms, Experimental; Orthomyxoviridae; Smoking; Vitamin A | 1974 |
1 trial(s) available for methylnitrosourea and Disease Models, Animal
| Article | Year |
|---|---|
Preclinical approaches to the development of effective immunotherapeutic protocols for the treatment of metastasis.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Immunotherapy; Interleukin-2; Killer Cells, Natural; Macrophage Activation; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasm Metastasis; Neoplasms, Radiation-Induced; Pyran Copolymer; Rats; Recombinant Proteins; Skin Neoplasms | 1986 |
211 other study(ies) available for methylnitrosourea and Disease Models, Animal
| Article | Year |
|---|---|
Electrical response of retinal ganglion cells in an N-methyl-N-nitrosourea-induced retinal degeneration porcine model.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Evoked Potentials, Visual; Female; Methylnitrosourea; Retinal Degeneration; Retinal Ganglion Cells; Swine; Swine, Miniature | 2021 |
Rhodopsin-positive cell production by intravitreal injection of small molecule compounds in mouse models of retinal degeneration.
Topics: Animals; Disease Models, Animal; Electroretinography; Intravitreal Injections; Methylnitrosourea; Mice; Retina; Retinal Degeneration; Rhodopsin; RNA, Messenger | 2023 |
Hyperoside alleviates photoreceptor degeneration by preventing cell senescence through AMPK-ULK1 signaling.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Cellular Senescence; Disease Models, Animal; Methylnitrosourea; Photoreceptor Cells, Vertebrate; Retina; Retinal Degeneration | 2023 |
Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments.
Topics: Animals; Apoptosis; Disease Models, Animal; Female; Injections, Intraperitoneal; Injections, Intravenous; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Taurine; Tomography, Optical Coherence; Vision Disorders | 2019 |
Optimized nonionic emulsifier for the efficient delivery of astaxanthin nanodispersions to retina:
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Carriers; Emulsifying Agents; Female; Male; Methylnitrosourea; Mice, Inbred C57BL; Nanoparticles; Photoreceptor Cells, Vertebrate; Retina; Retinal Degeneration; Xanthophylls | 2019 |
Aucubin, An Active Ingredient in
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA Damage; Iridoid Glucosides; Magnoliopsida; Male; Methylnitrosourea; Mice, Inbred C57BL; Oxidative Stress; Photoreceptor Cells, Vertebrate; Plant Extracts; Retina; Retinal Degeneration | 2019 |
Ultrastructural changes in the choriocapillaris of N-methyl-N-nitrosourea-induced retinal degeneration in C57BL/6 mice.
Topics: Animals; Apoptosis; Choroid; Disease Models, Animal; Humans; Injections, Intraperitoneal; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Microscopy, Electron; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Retinal Pigment Epithelium | 2020 |
Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Alkylating Agents; Animals; Benzamides; Benzodioxoles; Blotting, Western; Dark Adaptation; Disease Models, Animal; Electroretinography; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Injections, Intraperitoneal; Male; Methylnitrosourea; Photic Stimulation; Poly (ADP-Ribose) Polymerase-1; Rats; Rats, Sprague-Dawley; Retina; Retinitis Pigmentosa; Sirtuin 1; Tomography, Optical Coherence | 2020 |
Development of Animal Models for Lens and Corneal Diseases Using N-Methyl-N-Nitrosourea.
Topics: Alkylating Agents; Animals; Apoptosis; Corneal Diseases; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Immunohistochemistry; In Situ Nick-End Labeling; Lens Diseases; Methylnitrosourea; Rabbits; Rats; Reproducibility of Results | 2020 |
Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration.
Topics: Animals; Apoptosis; Disease Models, Animal; Female; Male; Mesenchymal Stem Cell Transplantation; Methylnitrosourea; Mice; Mice, Inbred C57BL; MicroRNAs; Photoreceptor Cells, Vertebrate; Retina; Retinal Degeneration | 2021 |
An experimental pig model with outer retinal degeneration induced by temporary intravitreal loading of N-methyl-N-nitrosourea during vitrectomy.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electroretinography; Intravitreal Injections; Methylnitrosourea; Retinal Degeneration; Swine; Swine, Miniature; Tomography, Optical Coherence; Vitrectomy | 2021 |
RPE-derived exosomes rescue the photoreceptors during retina degeneration: an intraocular approach to deliver exosomes into the subretinal space.
Topics: Alkylating Agents; Animals; Apoptosis; bcl-2-Associated X Protein; Biological Products; Calpain; Caspase 3; Disease Models, Animal; Electroretinography; Exosomes; Inflammation; Injections, Intraocular; Interleukin-1beta; Interleukin-6; Malondialdehyde; Methylnitrosourea; Mice; Oxidative Stress; Photoreceptor Cells, Vertebrate; Proto-Oncogene Proteins c-bcl-2; Retina; Retinal Degeneration; Retinal Pigment Epithelium; Tomography, Optical Coherence; Tumor Necrosis Factor-alpha; Vision, Ocular | 2021 |
Alterations of Lipidomes in Rat Photoreceptor Degeneration Induced by N-Methyl-N-nitrosourea.
Topics: Animals; Apoptosis; Cell Line; Disease Models, Animal; Docosahexaenoic Acids; Fatty Acids; Lipid Metabolism; Lipidomics; Lipids; Liver; Male; Methylnitrosourea; Mice; Neurons; Photoreceptor Cells, Vertebrate; Rats, Sprague-Dawley; Retinal Degeneration | 2021 |
Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by Upregulating Anti-Apoptotic Pathway.
Topics: Animals; Apoptosis; Cell Count; Cells, Cultured; Corneal Injuries; Disease Models, Animal; Endothelium, Corneal; Hydrogen; Male; Methylnitrosourea; Oxidative Stress; Rabbits; Rats; Transcriptional Activation; Up-Regulation | 2021 |
Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Damage; DNA Repair; F-Box-WD Repeat-Containing Protein 7; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Gene Order; Gene Targeting; Genes, myc; Genetic Loci; Genetic Predisposition to Disease; Genotype; Haploinsufficiency; Methylnitrosourea; Mice; Mice, Knockout; Models, Biological; Stomach Neoplasms | 2017 |
Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Circadian Rhythm; Disease Models, Animal; DNA Repair; Female; Jet Lag Syndrome; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Period Circadian Proteins; Rats; Rats, Inbred F344; Sirtuin 1 | 2017 |
The mongolian gerbil (Meriones unguiculatus) as a model for inflammation-promoted prostate carcinogenesis.
Topics: Animals; Carcinogenesis; Disease Models, Animal; Gerbillinae; Inflammation; Male; Methylnitrosourea; Prostatic Neoplasms | 2017 |
Endogenous controls of gene expression in N-methyl-N-nitrosourea-induced T-cell lymphoma in p53-deficient mice.
Topics: Alcohol Oxidoreductases; Animals; Disease Models, Animal; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Genes, Essential; Lymphoma, T-Cell; Methylnitrosourea; Mice; Mice, Knockout; Real-Time Polymerase Chain Reaction; Ribosomal Proteins; Tumor Suppressor Protein p53 | 2017 |
Hemin supports the survival of photoreceptors injured by N-Methyl-N-nitrosourea: The contributory role of neuroglobin in photoreceptor degeneration.
Topics: Animals; Disease Models, Animal; Electroretinography; Globins; Hemin; Methylnitrosourea; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroglobin; Oxidative Stress; Photoreceptor Cells; Photoreceptor Cells, Vertebrate; Retina; Retinal Degeneration | 2018 |
Neuroprotective effect of cannabinoid receptor 1 antagonist in the MNU-induced retinal degeneration model.
Topics: Alkylating Agents; Animals; Biomarkers; Blotting, Western; Cannabinoid Receptor Antagonists; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Patch-Clamp Techniques; Photoreceptor Cells, Vertebrate; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Retina; Retinal Degeneration; Rimonabant | 2018 |
Protein Carbonylation-Dependent Photoreceptor Cell Death Induced by N-Methyl-N-nitrosourea in Mice.
Topics: Aldehydes; Animals; Calpain; Cell Death; Disease Models, Animal; Eye Proteins; HSP70 Heat-Shock Proteins; Injections, Intraperitoneal; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Models, Molecular; Oxidative Stress; Protein Carbonylation; Retina; Retinal Degeneration; Retinitis Pigmentosa | 2018 |
Intravitreous Delivery of Αb-Crystallin Ameliorates N-Methyl-N-Nitrosourea Induced Photoreceptor Degeneration in Mice: An in vivo and ex vivo Study.
Topics: Animals; bcl-2-Associated X Protein; Caspase 3; Crystallins; Disease Models, Animal; Electroretinography; Intravitreal Injections; Malondialdehyde; Methylnitrosourea; Mice; Mice, Inbred C57BL; Photoreceptor Cells; Retina; Retinal Degeneration; Superoxide Dismutase; Tomography, Optical Coherence | 2018 |
ALA-mediated biphasic downregulation of α-7nAchR/HIF-1α along with mitochondrial stress modulation strategy in mammary gland chemoprevention.
Topics: Acetylcholine; Acetylcholinesterase; alpha-Linolenic Acid; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticarcinogenic Agents; Apoptosis; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Hypoxia-Inducible Factor 1, alpha Subunit; Lipid Metabolism; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mitochondria; Oxidative Stress; Rats, Wistar; Signal Transduction | 2019 |
Deregulation of the SRC Family Tyrosine Kinases in Gastric Carcinogenesis in Non-human Primates.
Topics: Animals; Cebus; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Methylnitrosourea; Neoplasm Metastasis; src-Family Kinases; Stomach Neoplasms; Up-Regulation | 2018 |
Palliative Role of Aqueous Ginger Extract on
Topics: Alkylating Agents; Animals; Disease Models, Animal; Glutathione Peroxidase; Humans; Lipid Peroxidation; Male; Methylnitrosourea; Neoplasms, Experimental; Oxidative Stress; Palliative Care; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Stomach Neoplasms; Zingiber officinale | 2020 |
Subcutaneous delivery of tauroursodeoxycholic acid rescues the cone photoreceptors in degenerative retina: A promising therapeutic molecule for retinopathy.
Topics: Animals; Apoptosis; Disease Models, Animal; Electroretinography; Female; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Oxidative Stress; Photoreceptor Cells, Vertebrate; Retina; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Retinal Ganglion Cells; Taurochenodeoxycholic Acid | 2019 |
Prevention of Helicobacter pylori-induced gastric cancers in gerbils by a DNA demethylating agent.
Topics: Adenocarcinoma; Animals; Azacitidine; Carcinogens; Decitabine; Disease Models, Animal; DNA Methylation; DNA-Cytosine Methylases; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Stomach Neoplasms | 2013 |
Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis.
Topics: Animals; Cell Communication; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Culture Media, Conditioned; Disease Models, Animal; Epithelial Cells; Fibroblasts; Humans; Interleukin-6; Methylnitrosourea; Mice; Models, Biological; Neoplastic Stem Cells; STAT3 Transcription Factor; Stomach Neoplasms; Stromal Cells | 2013 |
A new proposed rodent model of chemically induced prostate carcinogenesis: distinct time-course prostate cancer progression in the dorsolateral and ventral lobes.
Topics: Alkylating Agents; Animals; Disease Models, Animal; Disease Progression; Gerbillinae; Male; Methylnitrosourea; Prostate; Prostatic Neoplasms; Testosterone; Time Factors | 2013 |
N-methylnitrosourea aggravates gastrointestinal polyposis in Lkb1+/- mice.
Topics: AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinogens; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Female; Gastric Mucosa; Gastrointestinal Neoplasms; Methylnitrosourea; Mice; Mice, Knockout; Peutz-Jeghers Syndrome; Protein Serine-Threonine Kinases; Pyrazoles; Sulfonamides | 2013 |
Maternal dietary canola oil suppresses growth of mammary carcinogenesis in female rat offspring.
Topics: Animals; Body Weight; Carcinogenesis; Diet; Dietary Fats; Disease Models, Animal; Fatty Acids, Monounsaturated; Female; Lactation; Mammary Neoplasms, Experimental; Maternal Nutritional Physiological Phenomena; Methylnitrosourea; Pregnancy; Rapeseed Oil; Rats; Rats, Sprague-Dawley | 2013 |
Cyanidin-3-glucoside extracted from mulberry fruit can reduce N-methyl-N-nitrosourea-induced retinal degeneration in rats.
Topics: Alkylating Agents; Animals; Anthocyanins; Apoptosis; Disease Models, Animal; Electroretinography; Glucosides; Male; Methylnitrosourea; Morus; Night Vision; Photoreceptor Cells, Vertebrate; Plant Extracts; Rats; Rats, Sprague-Dawley; Retinal Degeneration | 2014 |
Characteristics of rod regeneration in a novel zebrafish retinal degeneration model using N-methyl-N-nitrosourea (MNU).
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Methylnitrosourea; Neuroglia; Regeneration; Retina; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Rhodopsin; Zebrafish | 2013 |
Protective effect of γ-tocopherol-enriched diet on N-methyl-N-nitrosourea-induced epithelial dysplasia in rat ventral prostate.
Topics: Administration, Oral; Animals; Antioxidants; Apoptosis; Cell Proliferation; Cyclooxygenase 2; Diet; Disease Models, Animal; Epithelium; gamma-Tocopherol; Glutathione S-Transferase pi; Male; Matrix Metalloproteinase 9; Methylnitrosourea; Prostate; Prostatic Diseases; Rats; Rats, Wistar; Receptors, Androgen | 2013 |
Excess weight gain accelerates 1-methyl-1-nitrosourea-induced mammary carcinogenesis in a rat model of premenopausal breast cancer.
Topics: Animals; Carcinogenesis; Carcinogens; Diet; Disease Models, Animal; Disease Susceptibility; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Obesity; Premenopause; Rats; Rats, Sprague-Dawley; Weight Gain | 2014 |
N -methyl- N -nitrosourea-induced retinal degeneration in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Biomarkers; Blotting, Western; Disease Models, Animal; Eye Proteins; Fluorescent Antibody Technique, Indirect; Injections, Intraperitoneal; Methylnitrosourea; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Retinal Neurons | 2014 |
Selective photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea.
Topics: Animals; Disease Models, Animal; Disease Progression; Electroretinography; Follow-Up Studies; Immunohistochemistry; Intravitreal Injections; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Tomography, Optical Coherence | 2014 |
Heat shock protein 70 induction by valproic acid delays photoreceptor cell death by N-methyl-N-nitrosourea in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Blotting, Western; Chromatin Immunoprecipitation; Disease Models, Animal; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Photoreceptor Cells; Retinal Degeneration; Valproic Acid | 2014 |
Urothelial carcinogen resistance driven by stronger Toll-like receptor 2 (TLR2) and Uroplakin III (UP III) defense mechanisms: a new model.
Topics: Animals; Apoptosis; Carcinoma, Transitional Cell; Cell Proliferation; Disease Models, Animal; Disease Resistance; Female; Methylnitrosourea; Phenotype; Proto-Oncogene Proteins c-myc; Rats; Rats, Inbred F344; Rats, Inbred Lew; Toll-Like Receptor 2; Urinary Bladder; Urinary Bladder Neoplasms; Uroplakin III | 2015 |
Stimulation of cannabinoid receptors by using Rubus coreanus extracts to control osteoporosis in aged male rats.
Topics: Aging; Animals; Disease Models, Animal; Male; Methylnitrosourea; Osteoporosis; Phytotherapy; Plant Extracts; Prostate; Prostatic Neoplasms; Rats; Receptors, Cannabinoid; Rubus | 2015 |
Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma in Situ; Carcinoma, Ductal, Breast; Carcinoma, Papillary; Disease Models, Animal; Drug Synergism; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mammary Neoplasms, Experimental; Melatonin; Methylnitrosourea; Pravastatin; Rats, Sprague-Dawley | 2014 |
Mutation detection in the promoter region of survivin gene on N-methyl-N-nitrosourea induced colon tumor model in experiment.
Topics: Animals; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Methylnitrosourea; Microtubule-Associated Proteins; Mutation; Promoter Regions, Genetic; Rats, Wistar; Survivin | 2014 |
N-methylnitrosourea–induced carcinoma as a model for laryngeal carcinogenesis.
Topics: Animals; Carcinogenesis; Carcinoma; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Instillation, Drug; Laryngeal Neoplasms; Laryngoscopy; Methylnitrosourea; Mice | 2014 |
Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models.
Topics: Alkylating Agents; Animals; Biomarkers, Tumor; Disease Models, Animal; Female; Humans; Hypoglycemic Agents; Mammary Neoplasms, Experimental; Metformin; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, SCID; Mice, Transgenic; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Distribution; Tumor Cells, Cultured | 2015 |
Multiple programmed cell death pathways are involved in N-methyl-N-nitrosourea-induced photoreceptor degeneration.
Topics: Alkylating Agents; Animals; Apoptosis; Calpain; Caspases; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; In Situ Nick-End Labeling; Injections, Intraperitoneal; Methylnitrosourea; Mice; Mice, Inbred C57BL; Photoreceptor Cells, Vertebrate; Real-Time Polymerase Chain Reaction; Retinal Degeneration; RNA, Messenger; Transcription Factor CHOP | 2015 |
Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Proliferation; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Female; Flavonoids; Fruit; Humans; Ki-67 Antigen; Mammary Neoplasms, Experimental; MCF-7 Cells; Methylnitrosourea; Polyphenols; Rats; Stilbenes; Tyrosine; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
Leaves of Persimmon (Diospyros kaki Thunb.) Ameliorate N-Methyl-N-nitrosourea (MNU)-Induced Retinal Degeneration in Mice.
Topics: Animals; Diospyros; Disease Models, Animal; Glial Fibrillary Acidic Protein; Humans; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Nestin; Plant Extracts; Plant Leaves; Retinal Degeneration | 2015 |
Role of high-fat diet on the effect of pioglitazone and melatonin in a rat model of breast cancer.
Topics: Animals; Antioxidants; Carcinogens; Diet, High-Fat; Disease Models, Animal; Drug Therapy, Combination; Female; Hypoglycemic Agents; Mammary Neoplasms, Experimental; Melatonin; Methylnitrosourea; Pioglitazone; Rats; Rats, Sprague-Dawley; Thiazolidinediones | 2016 |
Cell Fate of Müller Cells During Photoreceptor Regeneration in an N-Methyl-N-nitrosourea-Induced Retinal Degeneration Model of Zebrafish.
Topics: Animals; Bromodeoxyuridine; Cell Proliferation; Disease Models, Animal; Ependymoglial Cells; Female; Immunohistochemistry; Male; Methylnitrosourea; Photoreceptor Cells, Vertebrate; Proliferating Cell Nuclear Antigen; Regeneration; Retinal Degeneration; Zebrafish | 2016 |
Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers.
Topics: 1,2-Dimethylhydrazine; Animals; Antibodies, Protozoan; Antibody-Dependent Cell Cytotoxicity; Antigens, Protozoan; Breast Neoplasms; Cancer Vaccines; Carcinogens; Cell Line, Tumor; Colonic Neoplasms; Cross Reactions; Disease Models, Animal; Female; Flow Cytometry; Humans; Immunohistochemistry; Methylnitrosourea; Rats; Rats, Wistar; Trypanosoma cruzi | 2016 |
N-Methyl-N-Nitrosourea-Induced Acute Alteration of Retinal Function and Morphology in Monkeys.
Topics: Alkylating Agents; Animals; Dark Adaptation; Disease Models, Animal; Dose-Response Relationship, Drug; Electroretinography; Follow-Up Studies; Injections, Intravenous; Macaca fascicularis; Methylnitrosourea; Photic Stimulation; Photoreceptor Cells, Vertebrate; Retinal Degeneration | 2015 |
Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea in Male Sprague-Dawley Rats: A Possible Animal Model for Human Keratoacanthoma.
Topics: Animals; Biomarkers, Tumor; Disease Models, Animal; Epidermal Cyst; Humans; Immunohistochemistry; Keratoacanthoma; Male; Methylnitrosourea; Neoplasms, Glandular and Epithelial; Rats, Sprague-Dawley; Skin; Skin Neoplasms | 2016 |
Characterization of mammary adenocarcinomas in male rats after N-methyl-N-nitrosourea exposure--Potential for human male breast cancer model.
Topics: Adenocarcinoma; Animals; Breast Neoplasms, Male; Carcinogens; Disease Models, Animal; Female; Humans; Male; Mammary Glands, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Rats | 2016 |
Integrating Topographic Measures to Explore the Protective Effects of Peonidin Against the N-Methyl-N-Nitrosourea Induced Photoreceptor Degeneration.
Topics: Animals; Anthocyanins; Disease Models, Animal; Electroretinography; Female; Humans; Methylnitrosourea; Mice; Photoreceptor Cells, Vertebrate; Retinal Degeneration | 2016 |
Anti-cancer effects of Piper nigrum via inducing multiple molecular signaling in vivo and in vitro.
Topics: Angiogenic Proteins; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Breast Neoplasms; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Humans; Mammary Neoplasms, Experimental; MCF-7 Cells; Methylnitrosourea; Neoplasm Invasiveness; Neovascularization, Pathologic; Oxidative Stress; Phytotherapy; Piper nigrum; Plant Extracts; Plants, Medicinal; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Time Factors | 2016 |
Lycium barbarum polysaccharides attenuates N-methy-N-nitrosourea-induced photoreceptor cell apoptosis in rats through regulation of poly (ADP-ribose) polymerase and caspase expression.
Topics: Animals; Apoptosis; Caspases; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Lycium; Male; Methylnitrosourea; Photoreceptor Cells, Vertebrate; Phytotherapy; Plants, Medicinal; Poly(ADP-ribose) Polymerases; Protective Agents; Rats, Sprague-Dawley; Retinal Degeneration; Signal Transduction; Time Factors | 2016 |
Female rats induced with mammary cancer as a relevant animal model for doxorubicin-induced chemobrain in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Carcinogens; Cognition; Disease Models, Animal; Doxorubicin; Female; Humans; Mammary Neoplasms, Experimental; Memory Disorders; Memory, Episodic; Methylnitrosourea; Rats; Rats, Sprague-Dawley | 2016 |
Protective effects of hydrogen-rich saline against N-methyl-N-nitrosourea-induced photoreceptor degeneration.
Topics: Analysis of Variance; Animals; Apoptosis; Disease Models, Animal; Electroretinography; Hydrogen; Hypertonic Solutions; In Situ Nick-End Labeling; Injections, Intraperitoneal; Malondialdehyde; Methylnitrosourea; Oxidative Stress; Photoreceptor Cells, Vertebrate; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; Retinal Degeneration; Retinal Ganglion Cells; Superoxide Dismutase | 2016 |
N-methyl-N-nitrosourea-induced neuronal cell death in a large animal model of retinal degeneration in vitro.
Topics: Animals; Cell Death; Disease Models, Animal; Ependymoglial Cells; Immunohistochemistry; Methylnitrosourea; Neuroglia; Photoreceptor Cells, Vertebrate; Retina; Retinal Bipolar Cells; Retinal Degeneration; Retinal Neurons; Swine | 2016 |
Topographic Quantification of the Transcorneal Electrical Stimulation (TES)-Induced Protective Effects on N-Methyl-N-Nitrosourea-Treated Retinas.
Topics: Alkylating Agents; Animals; Cornea; Disease Models, Animal; Electric Stimulation; Electroretinography; Female; Immunohistochemistry; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Photoreceptor Cells, Vertebrate; Retina; Retinal Degeneration | 2016 |
Photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea (MNU) in rabbits: a pilot study.
Topics: Animals; Apoptosis; Disease Models, Animal; Electroretinography; Female; Immunohistochemistry; Intravitreal Injections; Methylnitrosourea; Photoreceptor Cells, Vertebrate; Pilot Projects; Rabbits; Retinal Degeneration; Tomography, Optical Coherence | 2017 |
Physical activity induced protection against breast cancer risk associated with delayed parity.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Collagen Type V; Cyclin-Dependent Kinase Inhibitor p57; Disease Models, Animal; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Methylnitrosourea; Parity; Physical Conditioning, Animal; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors; Urokinase-Type Plasminogen Activator | 2017 |
Nestin Expression in the Adult Mouse Retina with Pharmaceutically Induced Retinal Degeneration.
Topics: Animals; Blotting, Western; Calcium-Binding Proteins; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Immunohistochemistry; Leukocyte Count; Methylnitrosourea; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microscopy, Fluorescence; Nestin; Retina; Retinal Degeneration; Up-Regulation | 2017 |
The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration.
Topics: Animals; Anthraquinones; Apoptosis; Disease Models, Animal; Electroretinography; Humans; Methylnitrosourea; Mice; Photoreceptor Cells; Retina; Retinal Degeneration; Tomography, Optical Coherence | 2017 |
Cancer Targeting Potential of
Topics: Acid Phosphatase; Animals; Carcinogenesis; Carcinogens; Disease Models, Animal; Electrophoresis; Finasteride; Hydrogen-Ion Concentration; Kinetics; Male; Methylnitrosourea; Prostate; Prostatic Neoplasms; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Technetium; Time Factors; Tissue Distribution | 2017 |
The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Cyclohexenes; Dietary Supplements; Disease Models, Animal; Genitalia, Male; Incidence; Inositol; Limonene; Male; Matrix Metalloproteinases; Methylnitrosourea; Neoplasms; Plasminogen Activators; Random Allocation; Rats; Rats, Wistar; Terpenes; Time Factors | 2008 |
Carcinogenic comparative study on rasH2 mice produced by two breeding facilities.
Topics: Animals; Breeding; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Female; Genes, ras; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental | 2008 |
N-methylnitrosourea induced breast cancer in rat, the histopathology of the resulting tumours and its drawbacks as a model.
Topics: Animals; Carcinogens; Disease Models, Animal; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Invasiveness; Rats; Rats, Sprague-Dawley | 2009 |
Coexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley rats.
Topics: Animals; Carcinoma, Ductal, Breast; Diagnosis, Differential; Disease Models, Animal; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Multiple Primary; Rats; Rats, Sprague-Dawley | 2009 |
Lack of efficacy of the statins atorvastatin and lovastatin in rodent mammary carcinogenesis.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Atorvastatin; Bexarotene; Cell Proliferation; Diet; Disease Models, Animal; Female; Genes, erbB-2; Heptanoic Acids; Lovastatin; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Knockout; Mice, Transgenic; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Retinoid X Receptors; Tamoxifen; Tetrahydronaphthalenes; Treatment Outcome; Tumor Suppressor Protein p53 | 2009 |
Detection of localized retinal malfunction in retinal degeneration model using a multielectrode array system.
Topics: Alkylating Agents; Aminobutyrates; Animals; Cell Differentiation; Disease Models, Animal; Electroretinography; Excitatory Amino Acid Agonists; Immunohistochemistry; Light; Membrane Potentials; Methylnitrosourea; Mice; Mice, Inbred C57BL; Microelectrodes; Photic Stimulation; Photoreceptor Cells, Vertebrate; Rats; Receptors, Metabotropic Glutamate; Retinal Degeneration; Vision, Ocular | 2009 |
Early remodeling in an inducible animal model of retinal degeneration.
Topics: Alkylating Agents; Animals; Disease Models, Animal; Immunohistochemistry; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Nerve Degeneration; Nerve Regeneration; Neuronal Plasticity; Photoreceptor Cells, Vertebrate; Retina; Retinal Degeneration; Spatial Behavior; Visual Acuity | 2009 |
Gastric carcinogenesis by N-Methyl-N-nitrosourea is enhanced in db/db diabetic mice.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Diabetes Complications; Disease Models, Animal; Gastric Mucosa; Insulin; Leptin; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Precancerous Conditions; Stomach Neoplasms | 2009 |
Histological analysis of low dose NMU effects in the rat mammary gland.
Topics: Animals; Body Weight; Disease Models, Animal; Female; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Wistar; Species Specificity; Time Factors | 2009 |
A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Dietary Fats; Disease Models, Animal; Disease Progression; Energy Intake; Energy Metabolism; Estrogen Receptor alpha; Estrogens; Female; Interleukin-2; Interleukin-4; Menopause; Methylnitrosourea; Obesity; Ovariectomy; Ovary; Rats; Rats, Wistar; Sedentary Behavior; Weight Gain | 2010 |
Prostate carcinogenesis induced by N-methyl-N-nitrosourea (mnu) in gerbils: histopathological diagnosis and potential invasiveness mediated by extracellular matrix components.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Biomarkers, Tumor; Cell Proliferation; Collagen; Disease Models, Animal; Drug Therapy, Combination; Epithelial Cells; Extracellular Matrix; Gerbillinae; Inflammation; Male; Methylnitrosourea; Neoplasm Invasiveness; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Racemases and Epimerases; Reticulin; Testosterone; Time Factors | 2010 |
Ganoderma spore lipid inhibits N-methyl-N-nitrosourea-induced retinal photoreceptor apoptosis in vivo.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Electroretinography; Female; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Methylnitrosourea; Photoreceptor Cells, Vertebrate; Rats; Rats, Sprague-Dawley; Reishi; Retinitis Pigmentosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Null activity of selenium and vitamin e as cancer chemopreventive agents in the rat prostate.
Topics: Adenocarcinoma; Alkylating Agents; alpha-Tocopherol; Androgens; Animals; Antioxidants; Cyproterone Acetate; Disease Models, Animal; Drug Therapy, Combination; Male; Methylnitrosourea; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Rats; Rats, Wistar; Selenium Compounds; Selenomethionine; Testosterone; Vitamin E | 2010 |
26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.
Topics: Adenoma, Liver Cell; Administration, Oral; Animals; Carcinogenicity Tests; Carcinogens; Clofibrate; Diethylhexyl Phthalate; Disease Models, Animal; Female; Genes, ras; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Transgenic; Phthalic Acids; Pyrimidines; Time Factors | 2011 |
Evolution on experimental animal model for upper urothelium carcinogenesis.
Topics: Alkylating Agents; Animals; Biopsy; Citrates; Disease Models, Animal; Female; Kidney Medulla; Methylnitrosourea; Rats; Rats, Inbred F344; Sodium Citrate; Ureter; Urinary Bladder; Urography; Urologic Neoplasms; Urothelium | 2010 |
Mammary renin-angiotensin system-regulating aminopeptidase activities are modified in rats with breast cancer.
Topics: Aminopeptidases; Angiotensin III; Animals; CD13 Antigens; Disease Models, Animal; Female; Glutamyl Aminopeptidase; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Wistar; Renin-Angiotensin System | 2010 |
Wheel running-induced changes in plasma biomarkers and carcinogenic response in the 1-methyl-1-nitrosourea-induced rat model for breast cancer.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Motor Activity; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley | 2010 |
Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line; Chromosome Aberrations; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Repair; DNA Replication; Flap Endonucleases; Genetic Predisposition to Disease; Hydrogen Peroxide; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Mutant Strains; Microscopy, Fluorescence; Point Mutation | 2011 |
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.
Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Disease Models, Animal; DNA Methylation; Female; Gastrins; Gene Expression Regulation, Neoplastic; Gene Silencing; Helicobacter felis; Helicobacter Infections; Histones; Humans; Male; Methylnitrosourea; Mice; Mice, Knockout; Middle Aged; Neoplastic Stem Cells; Peptides; Promoter Regions, Genetic; RNA, Messenger; Stomach Neoplasms; Time Factors; Transfection; Trefoil Factor-1; Tumor Suppressor Proteins | 2011 |
Protective effect of lactofermented beetroot juice against aberrant crypt foci formation and genotoxicity of fecal water in rats.
Topics: Aberrant Crypt Foci; Animals; Beta vulgaris; Carcinogens; Colon; Colorectal Neoplasms; Comet Assay; Disease Models, Animal; Feces; Fermentation; In Situ Hybridization, Fluorescence; Lactobacillus; Male; Methylnitrosourea; Mutagenicity Tests; Plant Extracts; Plant Roots; Probiotics; Rats; Rats, Wistar | 2012 |
Correlation between high-resolution optical coherence tomography (OCT) images and histopathology in an N-methyl-N-nitrosourea-induced retinal degeneration rat model.
Topics: Alkylating Agents; Animals; Disease Models, Animal; Methylnitrosourea; Photoreceptor Cells, Vertebrate; Rats; Rats, Inbred BN; Retina; Retinal Degeneration; Time Factors; Tomography, Optical Coherence | 2011 |
Experimental gastric carcinogenesis in Cebus apella nonhuman primates.
Topics: Animals; Cebus; Cell Line; Crotalid Venoms; Disease Models, Animal; Gene Dosage; Gene Expression Regulation, Neoplastic; Immunohistochemistry; In Situ Hybridization, Fluorescence; Methylnitrosourea; Neoplasms, Experimental; Plant Extracts; Proto-Oncogene Proteins c-myc; RNA, Messenger; Stomach Neoplasms; Ultrasonography | 2011 |
Establishment of a mammary carcinoma cell line from Syrian hamsters treated with N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Carcinogens; Cell Line, Tumor; Cricetinae; Disease Models, Animal; Female; Mammary Neoplasms, Experimental; Mesocricetus; Methylnitrosourea | 2011 |
Retinas of the diurnal rodent Arvicanthis ansorgei are highly resistant to experimentally induced stress and degeneration.
Topics: Alkylating Agents; Animals; Circadian Rhythm; Disease Models, Animal; Electroretinography; Fatty Acids, Nonesterified; Light; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Muridae; Rats; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Species Specificity; Stress, Physiological | 2011 |
Anthocyanins from the seed coat of black soybean reduce retinal degeneration induced by N-methyl-N-nitrosourea.
Topics: Administration, Oral; Animals; Anthocyanins; Antioxidants; Disease Models, Animal; Electroretinography; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Glycine max; Male; Methylnitrosourea; Phytotherapy; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Seeds | 2012 |
Intraductal administration of a polymeric nanoparticle formulation of curcumin (NanoCurc) significantly attenuates incidence of mammary tumors in a rodent chemical carcinogenesis model: Implications for breast cancer chemoprevention in at-risk populations
Topics: Animals; Antineoplastic Agents; Biological Availability; Chemistry, Pharmaceutical; Curcumin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunoenzyme Techniques; Incidence; Mammary Neoplasms, Experimental; Methylnitrosourea; Nanoparticles; Polymers; Rats; Rats, Sprague-Dawley; Survival Rate; Tissue Distribution | 2012 |
Arachidonic acid supplementation during gestational, lactational and post-weaning periods prevents retinal degeneration induced in a rodent model.
Topics: Animals; Apoptosis; Arachidonic Acid; Dietary Supplements; Disease Models, Animal; Female; In Situ Nick-End Labeling; Lactation; Methylnitrosourea; Photoreceptor Cells, Vertebrate; Pregnancy; Rats; Rats, Inbred Lew; Retina; Retinal Degeneration | 2013 |
Newly developed mouse newborn behavioral testing method for evaluating the risk of neurotoxicity of environmental toxicants.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Ecotoxicology; Environmental Pollutants; Female; Male; Maternal Exposure; Methylnitrosourea; Mice; Mice, Inbred ICR; Motor Activity; Neurotoxicity Syndromes; Pregnancy; Prenatal Exposure Delayed Effects; Risk | 2013 |
Mouse models of Helicobacter-induced gastric cancer: use of cocarcinogens.
Topics: Animals; Carcinogens; Cell Proliferation; Culture Media; Culture Techniques; Cytokines; Disease Models, Animal; Drug Interactions; Epithelial Cells; Female; Helicobacter pylori; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Microbial Viability; Polymerase Chain Reaction; Specimen Handling; Stomach Neoplasms; Urease | 2012 |
Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in an N-methyl nitrosourea-induced breast cancer animal model.
Topics: Alkylating Agents; Angiogenesis Inhibitors; Animals; Anticarcinogenic Agents; Breast Neoplasms; Diet; Disease Models, Animal; Female; Isothiocyanates; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Tumor Burden | 2013 |
Role of melatonin and luzindole in rat mammary cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Disease Models, Animal; DNA Fragmentation; Estradiol; Female; Heme Oxygenase-1; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Melatonin; Methylnitrosourea; Oxidative Stress; Progesterone; Prolactin; Rats; Rats, Sprague-Dawley; Tryptamines | 2012 |
Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma.
Topics: Animals; Antioxidants; Diosgenin; Disease Models, Animal; Down-Regulation; Female; Lipid Peroxidation; Liver; Mammary Neoplasms, Animal; Methylnitrosourea; Phytotherapy; Plant Preparations; Rats; Rats, Sprague-Dawley; Saponins; Treatment Outcome; Trigonella | 2012 |
Defining the role of histone deacetylases in the inhibition of mammary carcinogenesis by dietary energy restriction (DER): effects of suberoylanilide hydroxamic acid (SAHA) and DER in a rat model.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Caloric Restriction; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Vorinostat | 2013 |
Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Northern; Body Weight; Diet, Reducing; Disease Models, Animal; Estradiol; Female; Fenretinide; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Progesterone; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley | 2002 |
Rapid induction of cataract by a single intraperitoneal administration of N-methyl-N-nitrosourea in 15-day-old Sprague-Dawley (Jcl: SD) rats.
Topics: Animals; Apoptosis; Cataract; Disease Models, Animal; Female; Injections, Intraperitoneal; Lens, Crystalline; Male; Methylnitrosourea; Pigment Epithelium of Eye; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2002 |
Variable E-cadherin expression in a MNU-induced colon tumor model in rats which exposed with 50 Hz frequency sinusoidal magnetic field.
Topics: Animals; Cadherins; Colon; Colonic Neoplasms; Disease Models, Animal; Electromagnetic Fields; Immunoenzyme Techniques; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Wistar | 2002 |
Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils.
Topics: Animals; Anti-Bacterial Agents; Carcinoid Tumor; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Incidence; Methylnitrosourea; Stomach Neoplasms | 2003 |
Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration.
Topics: Animals; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; Caspases; Cell-Free System; Cytochrome c Group; Disease Models, Animal; DNA Fragmentation; Enzyme Activation; In Situ Nick-End Labeling; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Mitochondria; Poly(ADP-ribose) Polymerases; Proteins; Retina; Retinal Degeneration; Retinal Rod Photoreceptor Cells | 2003 |
Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.
Topics: Animals; Anticarcinogenic Agents; Caloric Restriction; Carcinogens; Carotenoids; Chromatography, High Pressure Liquid; Disease Models, Animal; Disease-Free Survival; Lycopene; Male; Methylnitrosourea; Powders; Proportional Hazards Models; Prostatic Neoplasms; Rats; Rats, Wistar; Solanum lycopersicum; Survival Analysis | 2003 |
Treatment of 1-methyl-1-nitrosourea-induced mammary tumours with immunostimulatory CpG motifs and 13-cis retinoic acid in female rats: histopathological study.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; CpG Islands; Disease Models, Animal; Drug Therapy, Combination; Female; Isotretinoin; Mammary Neoplasms, Experimental; Methylnitrosourea; Oligodeoxyribonucleotides; Rats; Treatment Outcome | 2003 |
Characterization of new estrogen receptor destabilizing compounds: effects on estrogen-sensitive and tamoxifen-resistant breast cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Humans; Injections, Subcutaneous; Methylnitrosourea; Mice; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Transplantation, Heterologous | 2004 |
Functional characterization of the bladder cancer marker, BLCA-4.
Topics: Amino Acid Sequence; Animals; Antigens; beta-Galactosidase; Biomarkers, Tumor; Carcinogens; Cell Nucleus; Clinical Trials as Topic; Cloning, Molecular; Disease Models, Animal; Disease Progression; DNA, Complementary; Female; Humans; Immunoblotting; Methylnitrosourea; Molecular Sequence Data; Nuclear Proteins; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Inbred F344; RNA, Messenger; Sensitivity and Specificity; Sequence Homology, Amino Acid; Tissue Distribution; Transcription Factors; Transfection; Urinary Bladder Neoplasms | 2004 |
Immunobiological characterization of N -nitrosomethylurea-induced rat breast carcinomas: tumoral IL-10 expression as a possible immune escape mechanism.
Topics: Animals; Cytokines; Disease Models, Animal; Female; Immunohistochemistry; Interleukin-10; Leukocytes; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Wistar | 2004 |
Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil.
Topics: Administration, Inhalation; Aerosols; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Eflornithine; Fluorouracil; Laryngeal Neoplasms; Lung Neoplasms; Male; Mesocricetus; Methylnitrosourea; Pharyngeal Neoplasms | 2004 |
Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets.
Topics: Animals; Anticarcinogenic Agents; Caloric Restriction; Carotenoids; Disease Models, Animal; Drug Synergism; Lycopene; Male; Methylnitrosourea; Mice; Powders; Prostatic Neoplasms; Rats; Solanum lycopersicum; Testosterone; Vitamin E | 2004 |
Serum oxytocinase activity is related to tumor growth parameters in N-methyl nitrosourea induced rat breast cancer.
Topics: Animals; Body Weight; Carcinogens; Cystinyl Aminopeptidase; Disease Models, Animal; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Wistar | 2004 |
Lack of effects of postnatal exposure to a mixture of aryl hydrocarbon-receptor agonists on the development of methylnitrosourea-induced mammary tumors in sprague-dawley rats.
Topics: Age Factors; Alkylating Agents; Animals; Animals, Newborn; Benzofurans; Body Weight; Dibenzofurans, Polychlorinated; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Environmental Exposure; Environmental Pollutants; Estrous Cycle; Immunohistochemistry; Mammary Neoplasms, Experimental; Methylnitrosourea; Milk; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Risk Factors | 2004 |
Increased phospho-AKT is associated with loss of the androgen receptor during the progression of N-methyl-N-nitrosourea-induced prostate carcinogenesis in rats.
Topics: Alkylating Agents; Animals; Disease Models, Animal; Disease Progression; Male; Methylnitrosourea; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, Androgen | 2005 |
Susceptibility of Lobund-Wistar x Copenhagen hybrid rats to autochthonous prostate carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Chimera; Disease Models, Animal; Genetic Predisposition to Disease; Gonadal Steroid Hormones; Male; Methylnitrosourea; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Testosterone | 2005 |
Alpha-tocopherol suppresses mammary tumor sensitivity to anthracyclines in fish oil-fed rats.
Topics: Adipose Tissue; alpha-Tocopherol; Animals; Anthracyclines; Antibiotics, Antineoplastic; Antioxidants; Carcinogens; Diet; Disease Models, Animal; Drug Antagonism; Drug Resistance, Neoplasm; Epirubicin; Fatty Acids, Unsaturated; Female; Fish Oils; Malondialdehyde; Mammary Neoplasms, Experimental; Methylnitrosourea; Oxidants; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Inhibition of NMU-induced mammary tumorigenesis by dietary soy.
Topics: Alkylating Agents; Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Chemoprevention; Diet; Disease Models, Animal; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Receptor, ErbB-2; Receptors, Progesterone; Soybean Proteins | 2005 |
Hexachlorobenzene is a tumor co-carcinogen and induces alterations in insulin-growth factors signaling pathway in the rat mammary gland.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Drug Therapy, Combination; Female; Hexachlorobenzene; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Mammary Glands, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Phosphoproteins; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction | 2006 |
Enhancement by acrylamide of N-methyl-N-nitrosourea-induced rat mammary tumor development-possible application for a model to detect co-modifiers of carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acrylamide; Administration, Oral; Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Interactions; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Nitrosamines; Rats; Rats, Sprague-Dawley; Thyroid Neoplasms | 2005 |
Intravesical N-(4-hydroxyphenyl) retinamide and adriamycin induces apoptosis in bladder cancer.
Topics: Administration, Intravesical; Alkylating Agents; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; Cell Cycle; Disease Models, Animal; Doxorubicin; Female; Fenretinide; Flow Cytometry; In Situ Nick-End Labeling; Methylnitrosourea; Rats; Rats, Wistar; Urinary Bladder Neoplasms | 2006 |
Effects of ginger (Zingiber officinale Roscoe) on DNA damage and development of urothelial tumors in a mouse bladder carcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Disease Models, Animal; DNA Damage; Male; Methylnitrosourea; Mice; Neoplasm Invasiveness; Plant Extracts; Urinary Bladder Neoplasms; Urologic Neoplasms; Zingiber officinale | 2006 |
Characterization of a preclinical model of simultaneous breast and ovarian cancer progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Alkylating Agents; Animals; Carcinogens; Carcinoma, Intraductal, Noninfiltrating; Cell Proliferation; Cells, Cultured; Cocarcinogenesis; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Epithelium; Estrogen Receptor alpha; Estrogens; Female; Hyperplasia; Immunoenzyme Techniques; Ki-67 Antigen; Mammary Neoplasms, Experimental; Methylnitrosourea; Ovarian Neoplasms; Precancerous Conditions; Rats; Rats, Inbred F344 | 2007 |
Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats.
Topics: Alkylating Agents; Animals; Animals, Newborn; Carcinogens; Carcinoma in Situ; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Fungicides, Industrial; Hyperplasia; Maneb; Maternal Exposure; Maternal-Fetal Exchange; Methylnitrosourea; Pancreatic Neoplasms; Phenobarbital; Pregnancy; Quercetin; Rats; Rats, Wistar; Zineb | 2006 |
Use of IC tags in short-term carcinogenicity study on CB6F1 TGrasH2 mice.
Topics: Acetone; Animal Identification Systems; Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Female; Genes, ras; Male; Materials Testing; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasms, Experimental; Tetradecanoylphorbol Acetate | 2006 |
Effects of liarozole fumarate (R85246) in combination with tamoxifen on N-methyl-N-nitrosourea (MNU)-induced mammary carcinoma and uterus in the rat model.
Topics: Animals; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Drug Therapy, Combination; Female; Imidazoles; Methylnitrosourea; Ovariectomy; Rats; Rats, Sprague-Dawley; Tamoxifen; Uterus | 2007 |
A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models.
Topics: Administration, Oral; Animals; Breast Neoplasms; Cell Proliferation; Coumarins; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrone; Female; Gene Expression Regulation, Enzymologic; Humans; Leukocytes; Methylnitrosourea; Molecular Structure; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Signal Transduction; Steryl-Sulfatase; Sulfonamides; Sulfonic Acids; Tamoxifen; Tumor Cells, Cultured | 2007 |
Serial transplantation of NMU-induced rat mammary tumors: a model of human breast cancer progression.
Topics: Animals; Disease Models, Animal; Disease Progression; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Invasiveness; Neoplasm Transplantation; Rats; Rats, Inbred WF | 2007 |
Role of bacterial strain diversity of Helicobacter pylori in gastric carcinogenesis induced by N-methyl-N-nitrosourea in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Disease Models, Animal; Gastritis; Gerbillinae; Helicobacter pylori; Methylnitrosourea; Mice; Mice, Inbred C57BL; Stomach Neoplasms | 2007 |
Genetic ablation of cone photoreceptors eliminates retinal folds in the retinal degeneration 7 (rd7) mouse.
Topics: Animals; Apoptosis; Caspase 3; Diphtheria Toxin; Disease Models, Animal; Female; Fluorescent Antibody Technique, Indirect; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Peptide Fragments; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Retinal Diseases; Rod Opsins; Transducin; Transgenes | 2007 |
A method of producing carcinoma in upper aerodigestive tree and esophagus of the Syrian golden hamster using wounding and instillation of N-methylnitrosourea.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Chemoprevention; Cricetinae; Disease Models, Animal; Epithelium; Esophageal Neoplasms; Glottis; Laryngeal Neoplasms; Mesocricetus; Metaplasia; Methylnitrosourea; Mucous Membrane; Pharyngeal Neoplasms; Respiratory Mucosa; Trachea; Tracheal Neoplasms | 2007 |
Chondroitinase ABC treatment enhances synaptogenesis between transplant and host neurons in model of retinal degeneration.
Topics: Adaptation, Physiological; Animals; Chondroitin ABC Lyase; Darkness; Disease Models, Animal; Electroretinography; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neurons; Retina; Retinal Degeneration; Synapses; Vesicular Glutamate Transport Protein 1 | 2007 |
Protective effects of diets supplemented with omega-3 polyunsaturated fatty acids and calcium against colorectal tumor formation.
Topics: Animals; Anticarcinogenic Agents; Calcium Compounds; Colon; Colorectal Neoplasms; Dietary Supplements; Disease Models, Animal; Fatty Acids, Omega-3; Female; Glutathione Peroxidase; Male; Malondialdehyde; Methylnitrosourea; Oxidative Stress; Rats; Rats, Inbred F344; Superoxide Dismutase; Up-Regulation | 2008 |
Protective effect of Acticoa powder, a cocoa polyphenolic extract, on prostate carcinogenesis in Wistar-Unilever rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Body Weight; Cacao; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Disease Models, Animal; Flavonoids; Male; Methylnitrosourea; Phenols; Plant Extracts; Polyphenols; Prostatic Neoplasms; Rats; Rats, Wistar; Testosterone Propionate | 2008 |
Intravitreal injection of fluorochrome-conjugated peanut agglutinin results in specific and reversible labeling of mammalian cones in vivo.
Topics: Alkylating Agents; Animals; Biomarkers; Disease Models, Animal; Fluoresceins; Guinea Pigs; In Situ Nick-End Labeling; Injections; Macaca mulatta; Methylnitrosourea; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Peanut Agglutinin; Photoreceptor Cells, Vertebrate; Retinal Cone Photoreceptor Cells; Retinal Degeneration; Rhodamines; Staining and Labeling; Vitreous Body | 2008 |
Characteristics of bone marrow-derived microglia in the normal and injured retina.
Topics: Animals; Bone Marrow Cells; Chimera; Ciliary Body; Disease Models, Animal; Genes, Reporter; Green Fluorescent Proteins; Methylnitrosourea; Mice; Microglia; Reference Values; Retina; Retinal Degeneration; Retinal Detachment | 2008 |
[Tumour induction with alkyl-nitrosoureas in ribbed newts (Pleurodeles waltlii) (author's transl)].
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Fibrosarcoma; Hemangioma; Hemangiosarcoma; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pleurodeles; Salamandridae; Sarcoma, Experimental; Wilms Tumor | 1980 |
A clinically relevant canine lung cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Delayed-Action Preparations; Disease Models, Animal; Dogs; Lung Neoplasms; Methods; Methylcholanthrene; Methylnitrosourea; Neoplasms, Experimental; Radioisotopes; Tetradecanoylphorbol Acetate | 1981 |
N-nitrosomethylurea-induced rat mammary tumours as models of human breast cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Disease Models, Animal; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Nitrosourea Compounds; Rats; Rats, Inbred F344; Rats, Inbred WF | 1981 |
Histogenesis and dose dependence of N-methyl-N-nitrosourea-induced carcinoma in a localized area of the hamster trachea.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Male; Mesocricetus; Methylnitrosourea; Mucous Membrane; Neoplasms, Experimental; Nitrosourea Compounds; Time Factors; Tracheal Neoplasms | 1980 |
Carcinogenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea when applied to a localized area of the hamster trachea.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylnitrosourea; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Trachea; Tracheal Neoplasms | 1981 |
Oral carcinogenesis by intragastric N-methyl-N-nitrosourea in the Syrian hamster.
Topics: Animals; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Mesocricetus; Methylnitrosourea; Mouth Neoplasms; Nitrosourea Compounds; Stomach Neoplasms | 1980 |
Oral carcinogenesis by intraperitoneal N-methyl-N-nitrosourea in the Syrian hamster.
Topics: Animals; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Male; Mesocricetus; Methylnitrosourea; Mouth Neoplasms; Nitrosourea Compounds | 1980 |
Experimentally induced cranial meningocele and cerebral microgyria.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Brain Diseases; Disease Models, Animal; Female; Meningocele; Methylnitrosourea; Nitrosourea Compounds; Pregnancy; Rats | 1982 |
Carcinogenesis in heterotopically-transplanted urinary bladder by N-methyl-N-nitrosourea: a model for initiation and promotion.
Topics: Animals; Carcinogens; Disease Models, Animal; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Transplantation, Homologous; Urinary Bladder Neoplasms; Urine | 1981 |
Gross and microscopic pathology of induced prostatic complex tumors arising in Lobund-Wistar rats.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Histiocytoma, Benign Fibrous; Male; Methylnitrosourea; Microscopy; Prostatic Hyperplasia; Prostatic Neoplasms; Rats; Rats, Wistar | 1994 |
Inhibitory effects of medroxyprogesterone acetate on mouse endometrial carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Dose-Response Relationship, Drug; Endometrial Neoplasms; Endometrium; Estradiol; Female; Medroxyprogesterone Acetate; Methylnitrosourea; Mice; Mice, Inbred ICR; Proliferating Cell Nuclear Antigen | 1995 |
Effect of high-dose, fractionated local irradiation on MNU-induced carcinogenesis in the rat mammary gland.
Topics: Animals; Breast; Disease Models, Animal; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Radiation-Induced; Radiotherapy; Radiotherapy Dosage; Rats; Rats, Sprague-Dawley | 1995 |
Colon cancer prevention with a small amount of dietary perilla oil high in alpha-linolenic acid in an animal model.
Topics: alpha-Linolenic Acid; Animals; Body Weight; Cholesterol; Colon; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Eating; Fatty Acids; Female; Intestinal Mucosa; Linoleic Acids; Lipids; Methylnitrosourea; Phospholipids; Plant Oils; Rats; Rats, Inbred F344; Safflower Oil; Time Factors; Triglycerides | 1994 |
An experimental model for anaplastic astrocytomas and glioblastoma using adult F344 rats and N-methyl-N-nitrosourea.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Female; Glial Fibrillary Acidic Protein; Glioblastoma; Immunohistochemistry; Male; Methylnitrosourea; Microscopy, Electron; Rats; Rats, Inbred F344; Rats, Inbred Strains; Survival Analysis; Time Factors | 1993 |
Induction of glandular stomach cancers in C3H mice treated with N-methyl-N-nitrosourea in the drinking water.
Topics: Adenocarcinoma; Animals; Carcinoma, Signet Ring Cell; Diet; Disease Models, Animal; Hyperplasia; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Stomach Neoplasms | 1993 |
Tumor promotion by fecapentaene-12 in a rat colon carcinogenesis model.
Topics: Animals; Carcinogens; Cocarcinogenesis; Colonic Neoplasms; Disease Models, Animal; Female; Intestinal Mucosa; Methylnitrosourea; Polyenes; Rats; Rats, Inbred F344 | 1993 |
Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model.
Topics: Animals; Antioxidants; Body Weight; Butylated Hydroxyanisole; Carcinoma in Situ; Carcinoma, Squamous Cell; Catechols; Cocarcinogenesis; Dimethylhydrazines; Disease Models, Animal; Drug Interactions; Eating; Epithelium; Hyperplasia; Liver; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Size; Rats; Rats, Inbred F344; Sodium Nitrite; Stomach; Stomach Neoplasms | 1993 |
Hormone dependent and independent mammary tumor development form N-methyl-N-nitrosourea-treated rat mammary epithelial cell xenografts in the nude mouse: multiple pathways and H-ras activation.
Topics: Adenocarcinoma; Animals; Base Sequence; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Hyperplasia; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Point Mutation; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous | 1996 |
Exercise during adolescence and its effects on mammary gland development, proliferation, and nitrosomethylurea (NMU) induced tumorigenesis in rats.
Topics: Age Factors; Animals; Cell Division; Disease Models, Animal; Female; Incidence; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley | 1996 |
Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine in drinking water.
Topics: Adenocarcinoma; Administration, Oral; Animals; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Disease Susceptibility; Drinking; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms; Water | 1998 |
Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil.
Topics: Adenocarcinoma; Animals; Carcinogenicity Tests; Carcinogens; Carcinoma, Signet Ring Cell; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Stomach Neoplasms | 1998 |
Microsatellite instability in an animal model of mammary carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Repair; Female; Genetic Markers; Mammary Neoplasms, Experimental; Methylnitrosourea; Microsatellite Repeats; Rats; Rats, Sprague-Dawley | 1998 |
Transmurally absorbed intravesical chemotherapy with dimethylsulfoxide in an animal model.
Topics: Administration, Intravesical; Animals; Antibiotics, Antineoplastic; Carcinogens; Dimethyl Sulfoxide; Disease Models, Animal; Epirubicin; Excipients; Hyperplasia; Male; Methylnitrosourea; Mucous Membrane; Rats; Rats, Wistar; Urinary Bladder; Urinary Bladder Neoplasms | 1999 |
Effects of low dose catechol on glandular stomach carcinogenesis in BALB/c mice initiated with N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinogens; Catechols; Disease Models, Animal; Dose-Response Relationship, Drug; Gastric Mucosa; Humans; Immunohistochemistry; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Pepsinogen A; Stomach Neoplasms | 1999 |
Dose effects of flaxseed and its lignan on N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats.
Topics: Adenocarcinoma; Animals; Butylene Glycols; Carcinogens; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flax; Glucosides; Lignans; Mammary Neoplasms, Experimental; Methylnitrosourea; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley | 1999 |
S-allylcysteine, a garlic constituent, fails to inhibit N-methylnitrosourea-induced rat mammary tumorigenesis.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinogens; Chromatography, High Pressure Liquid; Cysteine; Diet; Disease Models, Animal; Disease-Free Survival; Female; Garlic; Mammary Neoplasms, Experimental; Methylnitrosourea; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley | 1999 |
c-fos controls the "private pathway" of light-induced apoptosis of retinal photoreceptors.
Topics: Alkylating Agents; Animals; Apoptosis; Dark Adaptation; Disease Models, Animal; DNA-Binding Proteins; Electroretinography; Female; Light; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Mitochondria; Proto-Oncogene Proteins c-fos; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Transcription Factor AP-1 | 2000 |
Prostate-seminal vesicle cancers induced in noble rats.
Topics: Animals; Disease Models, Animal; Genital Neoplasms, Male; Germ-Free Life; Male; Methylnitrosourea; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Seminal Vesicles; Testosterone | 2000 |
Dietary butyrate inhibits NMU-induced mammary cancer in rats.
Topics: Alkylating Agents; Animal Feed; Animals; Antineoplastic Agents; Butyrates; Dietary Fats; Disease Models, Animal; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Milk; Rats; Rats, Sprague-Dawley; Triglycerides | 2000 |
Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis.
Topics: Animals; Base Pair Mismatch; Chromosome Aberrations; Chromosome Fragility; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Disease Models, Animal; DNA Repair; DNA-Binding Proteins; Genetic Predisposition to Disease; Haplotypes; Loss of Heterozygosity; Methylnitrosourea; Mice; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Radiation, Ionizing; Sister Chromatid Exchange | 2000 |
Effect of dietary fatty acids on colon tumorigenesis induced by methyl nitrosourea in rats.
Topics: Alkylating Agents; Animals; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Fatty Acids; Fish Oils; Infusions, Parenteral; Male; Methylnitrosourea; Rats; Rats, Sprague-Dawley | 2000 |
Prevention of N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats by 1alpha-hydroxyvitamin D(5).
Topics: Animals; Anticarcinogenic Agents; Calcium; Carcinogens; Confidence Intervals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hydroxycholecalciferols; Incidence; Mammary Neoplasms, Experimental; Methylnitrosourea; Phosphorus; Rats; Rats, Sprague-Dawley | 2000 |
Cancer prevention by natural carotenoids.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Colonic Neoplasms; Cryptoxanthins; Disease Models, Animal; Fruit; Humans; Lutein; Lycopene; Methylnitrosourea; Mice; Rats; Rats, Inbred F344; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vegetables; Xanthophylls; Zeaxanthins | 2000 |
Role of N-methyl-N-nitrosourea in the induction of intestinal metaplasia and gastric adenocarcinoma in Mongolian gerbils infected with Helicobacter pylori.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Immunohistochemistry; Intestinal Mucosa; Intestinal Neoplasms; Male; Methylnitrosourea; Precancerous Conditions; Probability; Reference Values; Severity of Illness Index; Statistics, Nonparametric; Stomach Neoplasms | 2001 |
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.
Topics: Animals; Antineoplastic Agents; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Wistar; Tumor Cells, Cultured | 2001 |
Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Division; Cell Line; Chemoprevention; Colorectal Neoplasms; Disease Models, Animal; Drugs, Chinese Herbal; Endometrial Neoplasms; Estradiol; Female; Glycyrrhiza; Humans; Hyperplasia; Methylnitrosourea; Mice; Mice, Inbred ICR; Plants, Medicinal; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Tumor Cells, Cultured; Uterus | 2001 |
Helicobacter pylori does not promote N-methyl-N-nitrosourea-induced gastric carcinogenesis in SPF C57BL/6 mice.
Topics: Animals; Disease Models, Animal; Gastritis; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Specific Pathogen-Free Organisms; Stomach Neoplasms | 2002 |
Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin.
Topics: Administration, Oral; Alitretinoin; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Female; Injections, Subcutaneous; Mammary Neoplasms, Experimental; Melatonin; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Tretinoin | 2002 |
Nicotinamide prevents N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats and C57BL mice.
Topics: Alkylating Agents; Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; In Situ Nick-End Labeling; Methylnitrosourea; Mice; Mice, Inbred C57BL; Niacinamide; Photoreceptor Cells, Vertebrate; Rats; Rats, Sprague-Dawley; Retina; Retinitis Pigmentosa | 2002 |
The growth hormone-deficient Spontaneous Dwarf rat is resistant to chemically induced mammary carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; Cell Division; Crosses, Genetic; Disease Models, Animal; Dwarfism; Female; Growth Hormone; Human Growth Hormone; Humans; Insulin-Like Growth Factor I; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley | 2002 |
Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoviridae; Animals; Antiviral Agents; beta-Galactosidase; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Ganciclovir; Gene Expression Regulation, Developmental; Immunoenzyme Techniques; Incidence; Injections, Intralesional; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Inbred WF; Thymidine Kinase | 2002 |
Nitrosourea-induced brain tumors: an in vivo and in vitro tumor model system.
Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Immunosuppression Therapy; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Thymus Gland; Time Factors; Transplantation, Isogeneic | 1978 |
Studies with a new experimental model in respiratory carcinogenesis.
Topics: Animals; Cricetinae; Disease Models, Animal; Methods; Methylnitrosourea; Mucous Membrane; Neoplasms, Experimental; Time Factors; Trachea; Tracheal Neoplasms | 1979 |
1-methyl-1-nitrosourea induction of cancer in a localized area of the Syrian golden hamster trachea.
Topics: Adenocarcinoma; Animals; Cricetinae; Disease Models, Animal; Male; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Tracheal Neoplasms | 1979 |
Angioimmunoblastic lymphadenopathy, immunoblastic sarcoma of B cells. Animal model: autoimmune-prone inbred Armenian hamster.
Topics: Animals; Autoimmune Diseases; Cricetinae; Cricetulus; Disease Models, Animal; Humans; Lymphatic Diseases; Methylnitrosourea; Sarcoma, Experimental | 1978 |
Induction of tumors in heterotopic bladder by topical application of N-methyl-N-nitrosourea and N-butyl-N-(3-carboxypropyl)nitrosamine.
Topics: Animals; Carcinoma, Transitional Cell; Disease Models, Animal; Female; Hyperplasia; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Nitrosourea Compounds; Propionates; Rats; Rats, Inbred Strains; Transplantation, Isogeneic; Urinary Bladder; Urinary Bladder Neoplasms | 1978 |
Prophylaxis of bladder tumor implantation. Intravesical and systemic chemotherapy.
Topics: Animals; Antineoplastic Agents; Carcinoma, Transitional Cell; Disease Models, Animal; Doxorubicin; Female; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Podophyllotoxin; Thiotepa; Urinary Bladder; Urinary Bladder Neoplasms | 1976 |
Some results and prospects of transplacental carcinogenesis studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Animals; Brain; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nervous System Diseases; Nitrosourea Compounds; Organ Specificity; Placenta; Pregnancy; Rats | 1976 |
[Induction of malformations by N-methyl-N-nitrosourea (MNU) (author's transl))].
Topics: Animals; Disease Models, Animal; Female; Fetus; Humans; Infant, Newborn; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Rats | 1977 |
Effects of localized chemical carcinogenesis and immunosuppression upon bronchial preneoplasia in the dog.
Topics: Animals; Azathioprine; Benzopyrenes; Bronchial Neoplasms; Carcinogens; Disease Models, Animal; Dogs; Humans; Immunosuppressive Agents; Methylnitrosourea; Methylprednisolone; Precancerous Conditions; Radiography | 1977 |
Tumor-specific transplantation immunity to intracerebral challenge with cells from a methylnitrosourea- induced brain tumor.
Topics: Animals; Antigen-Antibody Reactions; Antigens, Neoplasm; Astrocytoma; Brain Neoplasms; Disease Models, Animal; Freund's Adjuvant; Immunotherapy; Methylnitrosourea; Neoplasm Transplantation; Rats; Transplantation Immunology; Transplantation, Homologous | 1975 |
Pancreatic adenocarcinoma in inbred guinea pigs induced by n-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Female; Guinea Pigs; Intestinal Neoplasms; Lymphoma; Male; Mesentery; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pancreas; Pancreatic Ducts; Pancreatic Neoplasms; Sex Factors; Stomach Neoplasms; Time Factors | 1975 |
Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma; Chemical Phenomena; Chemistry; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Homologous | 1975 |
Animal models for the study of dietary factors and cancer of the large bowel.
Topics: Animals; Colonic Neoplasms; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Guinea Pigs; Intestines; Lithocholic Acid; Methylnitrosourea; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Rats; Taurocholic Acid; Vitamin A Deficiency | 1975 |
A colon tumor model for anticancer agent evaluation.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Homologous | 1975 |
Suppression of colonic carcinogenesis by vitamin D in rats.
Topics: Animals; Colonic Neoplasms; Disease Models, Animal; Female; Hydroxycholecalciferols; Lithocholic Acid; Methylnitrosourea; Rats; Rats, Inbred F344; Vitamin D | 1992 |
Ductal carcinoma in situ in rat mammary gland.
Topics: Animals; Carcinoma in Situ; Carcinoma, Intraductal, Noninfiltrating; Disease Models, Animal; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Inbred Strains; Receptors, Estrogen | 1992 |
Animal models for chemoprevention of respiratory cancer.
Topics: Animals; Biotransformation; Carcinoma, Squamous Cell; Cricetinae; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Lung Neoplasms; Mesocricetus; Methylnitrosourea; Retinoids | 1992 |
Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Stomach Neoplasms; Time Factors | 1992 |
Changes of silver-stained nucleolar organizer regions in mouse endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17 beta-oestradiol.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Endometrial Neoplasms; Endometrium; Estradiol; Female; Hyperplasia; Methylnitrosourea; Mice; Mice, Inbred ICR; Nucleolus Organizer Region; Silver Staining | 1992 |
Early manifestations of induced prostate tumors in Lobund-Wistar rats.
Topics: Animals; Disease Models, Animal; Male; Methylnitrosourea; Prostatic Neoplasms; Rats; Testosterone | 1992 |
Mammary carcinogenesis induced by N-methyl-N-nitrosourea (MNU) and medroxyprogesterone acetate (MPA) in BALB/c mice.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Drug Synergism; Female; Mammary Neoplasms, Experimental; Medroxyprogesterone; Methylnitrosourea; Mice; Mice, Inbred BALB C; Receptors, Estrogen; Receptors, Progesterone | 1992 |
Bronchial and pulmonary carcinogenesis at focal sites in dogs and hamsters.
Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Bronchoscopy; Carcinogens; Cricetinae; Disease Models, Animal; Dogs; Drug Implants; Injections; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mucous Membrane | 1992 |
Modulation of N-nitrosomethylurea-induced mammary tumor promotion by dietary fiber and fat.
Topics: Animals; Body Weight; Charcoal; Dextrans; Dietary Fats; Dietary Fiber; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Estrogens; Estrus; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Progesterone; Radioimmunoassay; Rats; Rats, Inbred F344; Tritium | 1991 |
Pineal melatonin inhibition of tumor promotion in the N-nitroso-N-methylurea model of mammary carcinogenesis: potential involvement of antiestrogenic mechanisms in vivo.
Topics: Animals; Disease Models, Animal; Estradiol; Female; Mammary Neoplasms, Experimental; Melatonin; Methylnitrosourea; Mice; Neoplasm Recurrence, Local; Ovariectomy; Pineal Gland; Prolactin; Radioimmunoassay; Receptors, Estrogen; Tamoxifen | 1991 |
Differences in skin carcinogenesis by methylnitrosourea between mice of several strains.
Topics: Animals; Disease Models, Animal; Female; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasms, Experimental; Skin Neoplasms | 1991 |
Rapid induction of endometrial carcinoma in ICR mice treated with N-methyl-N-nitrosourea and 17 beta-estradiol.
Topics: Adenocarcinoma; Animals; Body Weight; Carcinoma, Squamous Cell; Disease Models, Animal; Endometrial Neoplasms; Estradiol; Female; Methylnitrosourea; Mice; Mice, Inbred ICR; Organ Size; Ovarian Cysts; Ovary; Uterine Cervical Neoplasms; Uterine Neoplasms; Uterus | 1991 |
Organ-specific modification of tumor development by low-dose combinations of agents in a rat wide-spectrum carcinogenesis model.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Pepsinogens; Pylorus; Rats; Rats, Inbred F344; Stomach Neoplasms; Urinary Bladder Neoplasms | 1991 |
Modifying responses of allyl sulfide, indole-3-carbinol and germanium in a rat multi-organ carcinogenesis model.
Topics: Allyl Compounds; Animals; Body Weight; Diethylnitrosamine; Disease Models, Animal; Germanium; Indoles; Kidney; Liver; Liver Neoplasms, Experimental; Lung; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Size; Rats; Rats, Inbred F344; Sulfides | 1991 |
Medium-term bioassay for carcinogens using multiorgan models.
Topics: Animals; Carcinogenicity Tests; Carcinogens, Environmental; Cocarcinogenesis; Disease Models, Animal; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344 | 1991 |
Characterization of an N-methyl-N-nitrosourea-induced autochthonous rat bladder cancer model.
Topics: Animals; Carcinoma, Transitional Cell; Cell Transformation, Neoplastic; Chromosome Aberrations; Disease Models, Animal; FANFT; Female; Methylnitrosourea; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1990 |
Effects of sex difference, gonadectomy, and estrogen on N-methyl-N-nitrosourea induced rat thyroid tumors.
Topics: Animals; Body Weight; Castration; Disease Models, Animal; Estradiol; Female; Gonadal Steroid Hormones; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Size; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Estrogen; Sex Factors; Thyroid Gland; Thyroid Neoplasms; Thyrotropin | 1990 |
[Experimental brain tumor in adult mongrel cat].
Topics: Animals; Brain Edema; Brain Neoplasms; Cats; Disease Models, Animal; Glioma; Methylnitrosourea; Neoplasm Transplantation; Rats; Tomography, X-Ray Computed | 1990 |
The antioxidant butylated hydroxytoluene can retard cerebellar degeneration induced transplacentally by a single low dosage of N-methyl-N-nitrosourea.
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Cerebellar Diseases; Cerebellum; Diet; Disease Models, Animal; Female; Methylnitrosourea; Mice; Nerve Degeneration; Pregnancy; Prenatal Exposure Delayed Effects; Purkinje Cells | 1989 |
Autochthonous prostate adenocarcinomas in Lobund-Wistar rats: a model system.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Lung Neoplasms; Male; Methylnitrosourea; Prostatic Neoplasms; Rats; Testosterone | 1987 |
Different autochthonous models of colorectal cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitrosamine; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rectal Neoplasms | 1986 |
Retinal degeneration in the mouse. A model induced transplacentally by methylnitrosourea.
Topics: Aging; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Methylnitrosourea; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Retina; Retinal Degeneration | 1986 |