methylnitrosourea has been researched along with Disease Exacerbation in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (27.27) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 15 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Campos, SGP; Góes, RM; Gonçalves, BF; Scarano, WR; Taboga, SR; Vilamaior, PSL | 1 |
| Anderson, SM; Edwards, DP; Giles, ED; Jindal, S; MacLean, PS; Schedin, P; Schedin, T; Thor, AD; Wellberg, EA | 1 |
| Burbano, RR; DA Rocha, CAM; DE Assumpção, PP; DE Castro Sant' Anna, C; DE Fátima Aquino Moreira Nunes, C; DE Fátima Ferreira Borges DA Costa, J; Lamarão, LM; Muniz, JAPC | 1 |
| Amorim, RL; de Campos, SG; Falleiros, LR; Góes, RM; Gonçalves, BF; Scarano, WR; Taboga, SR; Zanetoni, C | 1 |
| Du, G; Hou, X; Li, H; Li, J; Liu, W; Liu, Y; Sun, T; Wang, Y; Zhang, Y; Zhao, B | 1 |
| Bai, X; Chen, Z; Dai, Y; Gao, Q; Gao, T; Jia, C; Lai, P; Lin, J; Ren, Z; Song, Q; Wan, Z; Wang, Y; Zhang, Y; Zhao, A; Zhao, Z; Zheng, H; Zhou, X | 1 |
| Johnen, S; Mataruga, A; Müller, F; Pfarrer, C; Rösch, S; Walter, P | 1 |
| Brauer, HA; D'Arcy, M; Hamajima, N; Lampe, PD; Li, CI; Libby, TE; Thompson, HJ; Troester, MA; Yasui, YY | 1 |
| Adams, DJ; Balmain, A; Delrosario, R; Fredlund, E; Gurley, KE; Halliwill, KD; Jen, KY; Keane, TM; Kemp, CJ; Quigley, DA; Rashid, M; Rust, AG; To, MD; Westcott, PM | 1 |
| Franklin, T; Sarkar, DK; Zhang, C | 1 |
| Aruoma, OI; Bahorun, T; Bourdon, E; Kumar, A; Ramsaha, S; Sharma, P; Singh, RK; Somanah, J; Verma, S | 1 |
| Ding, H; Feng, G; Li, J; Lin, D; Liu, T; Luo, F; Ma, P; Wang, J; Xu, Y; Yang, K | 1 |
| Andrianakos, AG; Fleming-Elder, BK; Giles, ED; Gilman, KA; Jackman, MR; Johnson, GC; MacLean, PS; McDaniel, SM; Schedin, PJ; Shroyer, KR | 1 |
| Bevan, CL; Keun, HC; Teahan, O; Waxman, J | 1 |
| Brtko, J; Liska, J; Macejova, D; Ondkova, S | 1 |
| Bohlmann, R; Gieschen, H; Heinrich, N; Hoffmann, J; Hofmeister, H; Kroll, J; Künzer, H; Lichtner, RB; Nishino, Y; Parczyk, K; Sauer, G; Schneider, MR; Ulbrich, HF | 1 |
| Barder, T; Getzenberg, RH; Konety, BR; Myers, J; Van Le, TS | 1 |
| Boileau, TW; Clinton, SK; Erdman, JW; Liao, Z; Wang, S | 1 |
| Gulati, A; Rai, A; Rajeshkumar, NV | 1 |
| Fabian, CJ; Kimler, BF; Petroff, BK; Ting, AY | 1 |
| Chan, MM; Iglehart, JD; Lu, X; Merchant, FM; Miron, PL | 1 |
| Arends, MJ; Berry, RL; Brownstein, DG; Devenney, PS; Hagan, S; Harrison, DJ; Hooper, ML; Kolch, W; Luo, F; Patek, CE; Plowman, SJ; Rose, L; Sansom, OJ; Walker, M; Wallace, WA | 1 |
| Ito, N; Montesano, R; Ogawa, K; Shibata, MA; Shirai, T; Takahashi, S; Tsuda, H; Wild, CP | 1 |
| Guzman, RC; Hwang, SI; Nandi, S; Swanson, SM | 1 |
| Russo, IH; Russo, J | 1 |
| Aldaz, CM; Chen, Y; McKenzie, KE; Sukumar, S | 1 |
| Kawabe, M; Orita, SI; Ozaki, M; Shibata, MA; Shirai, T; Takahashi, S | 1 |
| Aldaz, CM; Armstrong, BA; Chen, Y; McKenzie, KE; Nagarajan, M; Sukumar, S | 1 |
| Archer, MC; Korkola, JE | 1 |
| Christov, K; Green, A; Shilkaitis, A | 1 |
| Bischoff, ED; Heyman, RA; Lamph, WW | 1 |
| Ide, F; Ishikawa, T; Itoh, R; Kawate, H; Nakabeppu, Y; Nawata, H; Noda, T; Sakumi, K; Sekiguchi, M; Tsuzuki, T | 1 |
| Bello-DeOcampo, D; Bice, G; DeMendonca-Calaca, W; Kleinman, HK; Quader, ST; Storto, PD; Webber, MM; Williams, DE | 1 |
1 review(s) available for methylnitrosourea and Disease Exacerbation
| Article | Year |
|---|---|
Experimentally induced mammary tumors in rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Diet; Disease Models, Animal; Disease Progression; Disease Susceptibility; Female; Gonadal Steroid Hormones; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Radiation-Induced; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1996 |
32 other study(ies) available for methylnitrosourea and Disease Exacerbation
| Article | Year |
|---|---|
Dual action of high estradiol doses on MNU-induced prostate neoplasms in a rodent model with high serum testosterone: Protective effect and emergence of unstable epithelial microenvironment.
Topics: Androgens; Animals; Carcinogenesis; Carcinogens; Disease Progression; DNA Damage; Epithelial Cells; Estradiol; Male; Methylnitrosourea; Prostate; Prostatic Neoplasms; Protective Factors; Rats | 2017 |
Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer.
Topics: Animals; Aromatase; Breast; Breast Neoplasms; Disease Progression; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; Metformin; Methylnitrosourea; Ovariectomy; Postmenopause; Rats; Stromal Cells; Tumor Microenvironment | 2018 |
Deregulation of the SRC Family Tyrosine Kinases in Gastric Carcinogenesis in Non-human Primates.
Topics: Animals; Cebus; Disease Models, Animal; Disease Progression; Gene Expression Regulation, Neoplastic; Methylnitrosourea; Neoplasm Metastasis; src-Family Kinases; Stomach Neoplasms; Up-Regulation | 2018 |
A new proposed rodent model of chemically induced prostate carcinogenesis: distinct time-course prostate cancer progression in the dorsolateral and ventral lobes.
Topics: Alkylating Agents; Animals; Disease Models, Animal; Disease Progression; Gerbillinae; Male; Methylnitrosourea; Prostate; Prostatic Neoplasms; Testosterone; Time Factors | 2013 |
Hypothermia activates adipose tissue to promote malignant lung cancer progression.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Alkylating Agents; Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferation; Cold-Shock Response; Disease Progression; DNA Damage; Epithelial-Mesenchymal Transition; Female; Humans; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Tumor Burden; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2013 |
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
Topics: Animals; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Proliferation; Disease Progression; Fatty Acids, Omega-3; Female; Humans; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Methylnitrosourea; Mice; Mice, Nude; Mice, SCID; Multiprotein Complexes; Neoplasm Transplantation; Neovascularization, Pathologic; Rats; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Selective photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea.
Topics: Animals; Disease Models, Animal; Disease Progression; Electroretinography; Follow-Up Studies; Immunohistochemistry; Intravitreal Injections; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Tomography, Optical Coherence | 2014 |
Dermcidin expression is associated with disease progression and survival among breast cancer patients.
Topics: Adenocarcinoma; Adult; Aged; Animals; Biomarkers, Tumor; Breast Neoplasms; Dermcidins; Disease Progression; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Middle Aged; Random Allocation; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Disease Progression; DNA Copy Number Variations; Female; Genes, ras; Genomic Instability; Germ-Line Mutation; Humans; Lung Neoplasms; Male; Methylnitrosourea; Mice; Models, Genetic; Mutation; Oncogene Protein p21(ras); Point Mutation; Proto-Oncogene Proteins p21(ras); Urethane | 2015 |
Inhibition of Mammary Cancer Progression in Fetal Alcohol Exposed Rats by β-Endorphin Neurons.
Topics: Alkylating Agents; Animals; beta-Endorphin; Bucladesine; Central Nervous System Depressants; Cytokines; Disease Progression; Disease Susceptibility; Epinephrine; Ethanol; Female; Granzymes; Hypothalamus; Interferon-gamma; Mammary Neoplasms, Experimental; Methylnitrosourea; Neurons; Norepinephrine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2016 |
Fermented papaya preparation modulates the progression of N-methyl-N-nitrosourea induced hepatocellular carcinoma in Balb/c mice.
Topics: Animals; Antioxidants; Blood Cell Count; Carica; Disease Progression; Fermentation; Fruit; Hemoglobins; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Plant Preparations | 2016 |
Bone marrow mesenchymal stem cells participate in prostate carcinogenesis and promote growth of prostate cancer by cell fusion in vivo.
Topics: Animals; Antigens, Ly; Carcinogenesis; Cell Fusion; Disease Progression; Leukocyte Common Antigens; Male; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, SCID; Mice, Transgenic; Neoplasms, Experimental; Prostate; Prostatic Neoplasms; Tumor Microenvironment | 2016 |
A surprising link between the energetics of ovariectomy-induced weight gain and mammary tumor progression in obese rats.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Dietary Fats; Disease Models, Animal; Disease Progression; Energy Intake; Energy Metabolism; Estrogen Receptor alpha; Estrogens; Female; Interleukin-2; Interleukin-4; Menopause; Methylnitrosourea; Obesity; Ovariectomy; Ovary; Rats; Rats, Wistar; Sedentary Behavior; Weight Gain | 2010 |
Metabolic signatures of malignant progression in prostate epithelial cells.
Topics: Amino Acids; Animals; Biomarkers, Tumor; Cell Line; Choline; Disease Progression; Epithelial Cells; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Metabolomics; Methylnitrosourea; Mice; Prostate; Prostatic Neoplasms; Tumor Cells, Cultured | 2011 |
Morphology of 1-methyl-1-nitrosourea induced rat mammary tumours after treatment with precursor of phytanic acid or its combination with vitamin D analogue.
Topics: Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Disease Progression; Drug Evaluation, Preclinical; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Phytanic Acid; Rats; Rats, Sprague-Dawley; Tumor Burden; Vitamin D | 2012 |
Characterization of new estrogen receptor destabilizing compounds: effects on estrogen-sensitive and tamoxifen-resistant breast cancer.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Disease Models, Animal; Disease Progression; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor Modulators; Estrogens; Female; Humans; Injections, Subcutaneous; Methylnitrosourea; Mice; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Transplantation, Heterologous | 2004 |
Functional characterization of the bladder cancer marker, BLCA-4.
Topics: Amino Acid Sequence; Animals; Antigens; beta-Galactosidase; Biomarkers, Tumor; Carcinogens; Cell Nucleus; Clinical Trials as Topic; Cloning, Molecular; Disease Models, Animal; Disease Progression; DNA, Complementary; Female; Humans; Immunoblotting; Methylnitrosourea; Molecular Sequence Data; Nuclear Proteins; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Inbred F344; RNA, Messenger; Sensitivity and Specificity; Sequence Homology, Amino Acid; Tissue Distribution; Transcription Factors; Transfection; Urinary Bladder Neoplasms | 2004 |
Increased phospho-AKT is associated with loss of the androgen receptor during the progression of N-methyl-N-nitrosourea-induced prostate carcinogenesis in rats.
Topics: Alkylating Agents; Animals; Disease Models, Animal; Disease Progression; Male; Methylnitrosourea; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, Androgen | 2005 |
Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats.
Topics: Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Disease Progression; Endothelin B Receptor Antagonists; Endothelins; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Paclitaxel; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Tissue Distribution | 2005 |
Characterization of a preclinical model of simultaneous breast and ovarian cancer progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Alkylating Agents; Animals; Carcinogens; Carcinoma, Intraductal, Noninfiltrating; Cell Proliferation; Cells, Cultured; Cocarcinogenesis; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Epithelium; Estrogen Receptor alpha; Estrogens; Female; Hyperplasia; Immunoenzyme Techniques; Ki-67 Antigen; Mammary Neoplasms, Experimental; Methylnitrosourea; Ovarian Neoplasms; Precancerous Conditions; Rats; Rats, Inbred F344 | 2007 |
Serial transplantation of NMU-induced rat mammary tumors: a model of human breast cancer progression.
Topics: Animals; Disease Models, Animal; Disease Progression; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Invasiveness; Neoplasm Transplantation; Rats; Rats, Inbred WF | 2007 |
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.
Topics: Animals; Disease Progression; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Knockout; Mutagenesis; Mutant Proteins; Protein Isoforms; ras Proteins; Signal Transduction; Tumor Burden | 2008 |
DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
Topics: Administration, Oral; Animals; Base Sequence; Butylhydroxybutylnitrosamine; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Deoxyguanosine; Disease Progression; DNA Adducts; DNA Damage; DNA Mutational Analysis; DNA, Neoplasm; Genes, ras; Injections, Intraperitoneal; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Neoplasm Invasiveness; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1994 |
Hormone dependent and independent mammary tumor development form N-methyl-N-nitrosourea-treated rat mammary epithelial cell xenografts in the nude mouse: multiple pathways and H-ras activation.
Topics: Adenocarcinoma; Animals; Base Sequence; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Hyperplasia; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Point Mutation; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous | 1996 |
Midkine in the progression of rat N-nitroso-N-methylurea-induced mammary tumors.
Topics: Adenocarcinoma; Animals; Carcinogens; Carrier Proteins; Cell Differentiation; Cytokines; Disease Progression; Gene Expression; Mammary Neoplasms, Experimental; Methylnitrosourea; Midkine; Rats; Rats, Inbred BUF; RNA, Messenger; Tretinoin; Tumor Cells, Cultured | 1996 |
Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)nitrosamine-treated rats and no suppression by indomethacin.
Topics: Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carcinogens; Carcinoma, Transitional Cell; Cocarcinogenesis; Disease Progression; Genes, p53; Indomethacin; Male; Methylnitrosourea; Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1997 |
Alterations in the Ha-ras-1 and the p53 pathway genes in the progression of N-methyl-N-nitrosourea-induced rat mammary tumors.
Topics: Animals; Carcinogens; Disease Progression; Female; Gene Amplification; Genes, p53; Genes, ras; Mammary Neoplasms, Experimental; Methylnitrosourea; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Inbred WF; Tumor Cells, Cultured | 1997 |
Resistance to mammary tumorigenesis in Copenhagen rats is associated with the loss of preneoplastic lesions.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Disease Progression; Drug Resistance; Female; Genes, ras; Genes, Tumor Suppressor; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Precancerous Conditions; Rats; Rats, Inbred WF | 1999 |
4-(hydroxyphenyl)retinamide selectively inhibits the development and progression of ductal hyperplastic lesions and carcinoma in situ in mammary gland.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma in Situ; Disease Progression; Drug Screening Assays, Antitumor; Female; Fenretinide; Hyperplasia; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 1999 |
Effect of the retinoid X receptor-selective ligand LGD1069 on mammary carcinoma after tamoxifen failure.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bexarotene; Carcinogens; Disease Progression; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Tamoxifen; Tetrahydronaphthalenes; Treatment Failure; Treatment Outcome | 1999 |
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice.
Topics: Adaptor Proteins, Signal Transducing; Alkylating Agents; Alleles; Animals; Carcinogens; Carrier Proteins; Codon; Disease Progression; DNA Mutational Analysis; DNA, Neoplasm; Gene Deletion; Genes, ras; Genetic Predisposition to Disease; Genotype; Intestinal Neoplasms; Lethal Dose 50; Lymphoma; Methylnitrosourea; Mice; Mice, Knockout; MutL Protein Homolog 1; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Thymus Neoplasms | 2000 |
Human cell lines as an in vitro/in vivo model for prostate carcinogenesis and progression.
Topics: Alkylating Agents; Animals; Carcinogenicity Tests; Cell Adhesion; Cell Culture Techniques; Cell Division; Chromosome Aberrations; Chromosome Disorders; Disease Progression; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Keratins; Male; Methylnitrosourea; Mice; Mice, Nude; Nandrolone; Neoplasm Invasiveness; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Transforming Growth Factor beta; Tumor Cells, Cultured | 2001 |