methylnitrosourea has been researched along with Cell Transformation, Neoplastic in 158 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 58 (36.71) | 18.7374 |
1990's | 41 (25.95) | 18.2507 |
2000's | 34 (21.52) | 29.6817 |
2010's | 24 (15.19) | 24.3611 |
2020's | 1 (0.63) | 2.80 |
Authors | Studies |
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Daino, K; Imaoka, T; Kakinuma, S; Kokubo, T; Nishimura, M; Nishimura, Y; Shimada, Y; Takabatake, M | 1 |
Faustino-Rocha, AI; Ferreira, R; Gama, A; Ginja, M; Neuparth, MJ; Oliveira, PA | 1 |
Ji, J; Jiang, Y; Liu, X; Qi, X; Ren, J; Yu, Y; Zhang, J; Zhu, Z | 1 |
Fang, M; Kang, HG; Ohman Strickland, PA; Zarbl, H | 1 |
Jian, YM; Sun, YN; Zhuang, S | 1 |
Anandi, L; Ashiq, KA; Bodakuntla, S; Chakravarty, V; Lahiri, M | 1 |
Akanuma, M; Hayakawa, Y; Hikiba, Y; Hirata, Y; Kinoshita, H; Koike, K; Maeda, S; Nakagawa, H; Nakata, W; Sakamoto, K; Sakitani, K; Serizawa, T; Shibata, W; Takahashi, R | 1 |
Ngalame, NN; Orihuela, RG; Person, RJ; Tokar, EJ; Waalkes, MP; Xu, Y | 1 |
Abdul Jalal, MI; Al-Astani Tengku Din, TA; Ariffin Wan Mansor, WN; Idris, FM; Jaafar, H; Shamsuddin, SH | 1 |
Adams, DJ; Balmain, A; Delrosario, R; Fredlund, E; Gurley, KE; Halliwill, KD; Jen, KY; Keane, TM; Kemp, CJ; Quigley, DA; Rashid, M; Rust, AG; To, MD; Westcott, PM | 1 |
Faustino-Rocha, AI; Ferreira, R; Gama, A; Ginja, M; Oliveira, PA | 1 |
Ishchenko, IY; Kabakov, AV; Kazakov, OV; Konenkov, VI; Michurina, SV; Poveshchenko, AF; Raiter, TV; Strunkin, DN | 1 |
Hikiba, Y; Karin, M; Maeda, S; Nakagawa, H; Ogura, K; Omata, M; Sakamoto, K; Shibata, W; Yanai, A | 1 |
Ban, H; Cao, XY; Hirata, A; Masegi, T; Oshima, M; Sakai, H; Takasu, S; Tatematsu, M; Toyoda, T; Tsukamoto, T; Yamamoto, M; Yanai, T | 1 |
Adorini, L; Atalla, N; Buckley, B; Conney, AH; Lee, HJ; Lin, X; Lou, YR; Lu, G; Maehr, H; Paul, S; Suh, N; Thomas, PE; Uskokovic, M; Yang, I; Zheng, X | 1 |
Liu, J; Liu, W; Phang, JM; Qu, W; Tokar, EJ; Waalkes, MP; Webber, MM | 1 |
Betz, KS; Giraud, AS; Jin, G; Kawakami, K; Lerkowit, N; Menheniott, TR; Minamoto, T; Rio, MC; Shibata, W; Takaishi, S; Tomasetto, C; Tomita, H; Varro, A; Wang, TC; Yang, X | 1 |
Brtko, J; Jakubíková, L; Liška, J; Macejová, D; Mlynarčíková, A; Ondková, S; Scsuková, S | 1 |
Aliaga, C; Bruggeman, R; Calcagnotto, A; Cooper, TK; Das, A; Dickinson, R; El-Bayoumy, K; Liao, J; Manni, A; Prokopczyk, B; Richie, JP; Trushin, N; Verderame, MF; Washington, S; Xu, H | 1 |
Kanematsu, S; Kuwata, M; Lai, YC; Tsubura, A; Yoshizawa, K; Yuri, T | 1 |
Guo, K; Huang, S; Jia, Z; Kong, X; Le, X; Li, Q; Mishra, L; Tan, D; Wang, L; Wei, D; Xie, K | 1 |
Bespalov, VG; Chepik, OF; Murazov, IaG; Panchenko, AV | 1 |
Jiang, W; McGinley, JN; Neil, ES; Thompson, HJ; Zacher, JH; Zhu, Z | 1 |
Hongxia, X; Hui, C; Jundong, Z; Lijia, Y; Long, Y; Mantian, M; Qianyong, Z; Yong, Z; Yujie, F | 1 |
Bender, D; DeGeest, K; Engelhardt, JF; Fornalik, H; Goodheart, MJ; Liu, X; Meyerholz, DK; Neff, T; Park, SY; Shelton, DN; Xie, W | 1 |
Aliaga, C; Bidinotto, LT; de Cicco, RL; El-Bayoumy, K; Manni, A; Russo, IH; Russo, J; Santucci-Pereira, J; Vanden Heuvel, JP; Vanegas, JE; Washington, S; Xu, H | 1 |
Bojkova, B; Garajova, M; Kajo, K; Kassayova, M; Kiskova, T; Korpova, M; Kubatka, P; Miklosova, M; Orendas, P; Pec, M | 1 |
Jiang, W; McGinley, JN; Thompson, HJ; Zhu, Z | 1 |
Fukamachi, K; Han, BS; Maeda, M; Ohnishi, T; Takasuka, N; Tsuda, H; Yamasaki, T | 1 |
Fukaura, Y; Narisawa, T | 1 |
Calabro, JM; Maffini, MV; Sonnenschein, C; Soto, AM; Ucci, AA | 1 |
Gilbert, P; Weaver, VM | 1 |
Inoue, A; Jing, L; Leanderson, T; Li, V; Mikheev, AM; Mikheeva, SA; Zarbl, H | 1 |
Ahmed, MM; Kokkinakis, DM; Luo, J; Rushing, EJ; Shareef, MM; Singha, UK; Yang, S | 1 |
Jiang, W; McGinley, J; Thompson, HJ; Wolfe, P; Zhu, Z | 1 |
Pollard, M; Suckow, MA; Wolter, W | 1 |
Cho, YM; Hasumura, M; Hirose, M; Imai, T | 1 |
Kijkuokool, P; Malaivijitnond, S; Parhar, IS | 1 |
Christov, K; Green, A; Lubet, R; Punj, V; Shilkaitis, A; Steele, V | 1 |
Asaka, M; Kato, S; Katsuyama, T; Kumagai, T; Mizoshita, T; Ota, H; Tanaka, H; Tatematsu, M; Tsukamoto, T | 1 |
Brinkley, WR; Edwards, DG; Goepfert, TM; Medina, D; Moreno-Smith, M; Pathak, S | 1 |
Bisson, JF; Guardia-Llorens, MA; Hidalgo, S; Messaoudi, M; Rozan, P | 1 |
Simmen, FA; Simmen, RC; Su, Y; Xiao, R | 1 |
D'Eustachio, P; Guerrero, I; Pellicer, A; Villasante, A | 1 |
Fey, F | 1 |
Hodges, GM; Nathrath, WJ; Summerhayes, IC; Trejdosiewicz, LK; Wilson, PD | 1 |
Cato, KD; Grubbs, CJ; Peckham, JC | 1 |
Singer, B | 1 |
Bouck, N; di Mayorca, G | 1 |
Hanna, CH; Kaplan, AE; Tralka, TS; Yamaguchi, MK | 1 |
Cohen, BI; Deschner, EE; Raicht, RF | 1 |
Balwierz, PS; Molinary, SV; Oshiro, Y | 1 |
Marsh, WH; Parsa, I; Sutton, AL | 1 |
Kawai, K; Kawamata, H; Okamoto, M; Oyasu, R | 1 |
Collins, G; Guzman, RC; Nandi, S; Swanson, SM; Tafoya, P; Talamantes, F; Thordarson, G | 1 |
McNary, MQ; Singletary, KW | 1 |
Hubchak, S; Laconi, S; Mangino, MM; Mangold, KA; Scarpelli, DG | 1 |
Bera, TK; Enami, J; Guzman, RC; Hanyu, K; Miyamoto, S; Nandi, S; Panda, DK; Sasaki, M | 1 |
Christov, K; Guzman, RC; Miyamoto, S; Nandi, S; Swanson, SM | 1 |
Laduca, JR; Sinha, DK | 2 |
Garrett, LR; Klingelhutz, AJ; McDougall, JK; Smith, PP | 1 |
Garrett, LR; McDougall, JK; Perez-Reyes, N; Smith, PP | 1 |
Kawai, K; Okamoto, M; Oyasu, R; Reznikoff, CA | 1 |
Hukku, B; Jin, S; Jung, M; Kuettel, MR; Rhim, JS; Thraves, PJ; Webber, MM | 1 |
Okamoto, M; Oyasu, R | 1 |
Carey, LA; Dome, JS; Hedican, C; Jiang, C; Sukumar, S; Thompson, HJ; Umbricht, CB; Varon, D | 1 |
Okamoto, M; Oyasu, R; Quader, S; Webber, MM | 1 |
Dahiya, R; Lee, C; Thompson, HJ; Zhu, Z | 1 |
Bera, TK; Guzman, RC; Huang, T; Hwang, SI; Nandi, S; Panda, DK; Tsukamoto, T | 1 |
Heddle, JA | 1 |
Asakura, S; Daimon, H; Sagami, F; Sawada, S | 1 |
Hamamoto, N; Hamamoto, Y; Nakajima, T; Ozawa, H | 1 |
Chow, M; Rubin, H | 1 |
Allay, E; Gerson, SL; Veigl, M | 1 |
Bosland, MC; Condon, MS; Crivello, JF; Horton, L; Kaplan, LA | 1 |
Chen, X; Guzman, RC; Huang, T; Kitamura, T; Nandi, S; Pascual, RV; Tsukamoto, T | 1 |
Selby, PB | 1 |
Gau, E; Geisen, C; Haas, K; Karsunky, H; Möröy, T; Schmidt, T; Zevnik, B | 1 |
Christov, K; Green, A; Kelloff, G; Lubet, R; Shilkaitis, A; Steele, V | 1 |
Clarkin, KZ; Gomez, G; Infante, AJ; Kraig, E; Richie, ER | 1 |
Cohen, LA; Pittman, B; Scimeca, JA; Zhao, Z | 1 |
Chen, B; Wang, G; Wang, P; Zhou, S | 1 |
Boley, SE; Maher, VM; McCormick, JJ; McManus, TP | 1 |
Chen, BQ; Wang, GJ; Zhou, SB; Zhu, Y | 1 |
Dagar, S; Onyüksel, H; Rubinstein, I; Sekosan, M | 1 |
Elsässer-Beile, U; Freudenberg, N; Mengs, U; Ruhnau, T; Wetterauer, U | 1 |
Rao, MS; Reddy, JK | 1 |
Frei, JV | 1 |
Honig, LS; Kokkinakis, DM; Mickey, BE; Rushing, EJ; Schold, SC; Watson, ML | 1 |
Fukushima, S | 1 |
Asamoto, M; Naito, A; Ochiya, T; Ota, T; Sekiya, T; Terada, M; Toriyama-Baba, H; Tsuda, H | 1 |
Archer, MC; Chittim, BG; Desaulniers, D; Leingartner, K; Perkins, G; Russo, J; Wade, M; Yang, J | 1 |
Huberman, E; Sachs, L; Traut, M | 1 |
Bello-DeOcampo, D; Kleinman, HK; Quader, ST; Webber, MM; Williams, DE | 1 |
Duesberg, P; Fabarius, A; Hehlmann, R; Willer, A; Yerganian, G | 1 |
Conneely, OM; Gay, J; Hilsenbeck, SG; Medina, D; O'Malley, BW; Shine, HD; Sivaraman, L | 1 |
Badamchian, M; Goldstein, AL; Moody, TW; Tuthill, C | 1 |
Nandi, S; Richards, J | 1 |
Bannasch, P; Engelhardt, A | 1 |
Thust, R | 1 |
Bilello, JA; Freedman, VH; Shin, S | 1 |
Howett, MK; Pegg, AE; Rapp, F | 1 |
Anichkov, NM | 1 |
Benda, P; Levy, S; Markovits, P; Nocentini, S; Papadopoulo, D; Tripier, MF | 1 |
Naha, PM | 2 |
Kirkland, DJ | 1 |
Palestro, G; Stramignoni, A | 1 |
Dexter, TM; Laijtha, LG | 1 |
Armstrong, C; Harris, RJ; Kirkland, DJ | 1 |
di Mayorca, G; Kimball, P; Mishra, N | 1 |
Golub, NI; Kolesnichenko, TS; Shabad, LM | 1 |
Ostrovskaia, LA; Vermel', EM | 1 |
Salamon, DP; Wani, AA; Yamasaki, EF | 1 |
Rabes, HM; Waldmann, V | 1 |
Rabes, HM; Zeindl-Eberhart, E | 1 |
Alexander, RJ; Buxbaum, JN; Garte, SJ; Raicht, RF | 1 |
Castonguay, A; Goldblatt, PJ; Gunning, WT; Stoner, GD | 1 |
Maheshwari, KK; Parsa, I | 1 |
Wong, JL; Yuan, B | 1 |
Bassin, RH; Ciardiello, F; Colucci-D'Amato, GL; Kim, N; Salomon, DS; Valverius, EM | 1 |
Guzman, RC; Miyamoto, S; Nandi, S; Osborn, RC; Sukumar, S | 1 |
Barbacid, M; Kumar, R; Sukumar, S | 1 |
Basu, A; Modak, MJ; Osborne, MP; Telang, NT | 1 |
Brendler, CB; Ichikawa, T; Isaacs, JT; Squire, RA; Steinberg, GD | 1 |
Azuma, M; Momose, H; Oyasu, R | 1 |
Banerjee, MR; Delp, CR; Treves, JS | 1 |
Barbacid, M; Sukumar, S | 1 |
Jani, H; Knowles, MA | 1 |
Green, MH; Hall, J; Karran, P; Kataoka, H; Lowe, JE; Petit-Frère, C | 1 |
Bouffler, SD; Hatton, DH; Johnson, RT; Margison, GP; Musk, SR | 1 |
Anderson, MW; Candrian, U; Maronpot, RR; Stoner, GD; You, M | 1 |
Hastrup, J; Langkilde, NC; Olsen, S; Orntoft, TF; Wolf, H | 1 |
Banerjee, MR; Manoharan, K | 1 |
Maguire, S; Rabes, HM | 1 |
Ball, JK; Cooper, CS; Gardner, E; Harris, G; Lawley, PD; Warren, W | 1 |
Cooper, CS; Newbold, RF; Shiner, AC | 1 |
Barbacid, M | 1 |
Hawrylewicz, EJ | 1 |
Asch, BB; Bartley, JC; Guzman, RC; Imagawa, W; Nandi, S; Osborn, RC | 1 |
Frederick, J; Reina, D; Russo, IH; Russo, J | 1 |
de Campos Vidal, B; Russo, J | 1 |
Bloch, A; Guan, XP | 1 |
Diamond, LE; Guerrero, I; Pellicer, A | 1 |
Kadlubar, FF; Kumari, L; Lehman, TA; Milo, GE; Noyes, I; Oldham, JW; West, RW | 1 |
Eydmann, ME; Knowles, MA; Padua, RA; Proctor, A; Roberts, J | 1 |
Sakagishi, Y; Sakamoto, Y; Sonoda, M; Uyemura, K; Yano, K | 1 |
Guzman, RC; Miyamoto, S; Nandi, S; Osborn, RC | 1 |
Hann, M; Schmidt, H; Waldbaur, H | 1 |
Gassner, G; Kunze, E | 1 |
Carter, TH; Zelinsky-Papez, K; Zimmerman, JA | 1 |
Day, RS; DiPaolo, JA; Doniger, J | 1 |
Dave, H; Harvey, AE; Hicks, RM; Knowles, MA; Roberts, AB; Sporn, MB | 1 |
Cottrell, JR; Hudson, EA; Jones, RT; Resau, JH; Trump, BF | 1 |
Berry, RJ; Hicks, RM; Jani, H; Knowles, MA | 1 |
Kreja, L; Seidel, HJ | 1 |
Ashworth, M; Naha, PM | 1 |
5 review(s) available for methylnitrosourea and Cell Transformation, Neoplastic
Article | Year |
---|---|
N-Methyl-N-nitrosourea as a mammary carcinogenic agent.
Topics: Animals; Breast; Carcinogens; Cell Transformation, Neoplastic; DNA; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea | 2015 |
The use of transgenic animals in research.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Animals, Genetically Modified; Carcinogens, Environmental; Cell Transformation, Neoplastic; Codon; Genes, ras; Liver; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Knockout; Mitosis; Mutagenesis; Mutagenicity Tests; Mutagens; Neoplasms; Polymerase Chain Reaction; Rats; Sensitivity and Specificity; Transgenes | 1998 |
[Experimental replication of bladder tumors. Morphologic features of early stages of their development].
Topics: 2-Acetylaminofluorene; 2-Naphthylamine; Animals; Butylhydroxybutylnitrosamine; Cell Membrane; Cell Transformation, Neoplastic; DNA, Neoplasm; Epithelium; FANFT; Humans; Hyperplasia; Methylcholanthrene; Methylnitrosourea; Mice; Microscopy, Electron; Naphthalenes; Neoplasms, Experimental; Papilloma; Rats; Schistosoma haematobium; Species Specificity; Sulfonamides; Urinary Bladder Neoplasms | 1979 |
Oncogenes and human cancer: cause or consequence?
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Chromosome Mapping; Gene Expression Regulation; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Neoplasms; Neoplasms, Experimental; Oncogenes; Proto-Oncogenes; Rats; Retroviridae; Skin Neoplasms | 1986 |
Fat-protein interaction, defined 2-generation studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Body Weight; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Dietary Proteins; Disease Models, Animal; Eating; Epidemiologic Methods; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Prolactin; Thymidine | 1986 |
153 other study(ies) available for methylnitrosourea and Cell Transformation, Neoplastic
Article | Year |
---|---|
Copenhagen Rats Display Dominantly Inherited Yet Non-uniform Resistance to Spontaneous, Radiation-induced, and Chemically-induced Mammary Carcinogenesis.
Topics: Animals; Breast Neoplasms; Cell Transformation, Neoplastic; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley | 2022 |
Mast Cells in Mammary Carcinogenesis: Host or Tumor Supporters?
Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Female; Immunohistochemistry; Ketotifen; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mast Cells; Methylnitrosourea; Rats; Rats, Sprague-Dawley | 2017 |
Fbxw7 haploinsufficiency loses its protection against DNA damage and accelerates MNU-induced gastric carcinogenesis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Damage; DNA Repair; F-Box-WD Repeat-Containing Protein 7; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Gene Order; Gene Targeting; Genes, myc; Genetic Loci; Genetic Predisposition to Disease; Genotype; Haploinsufficiency; Methylnitrosourea; Mice; Mice, Knockout; Models, Biological; Stomach Neoplasms | 2017 |
Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Circadian Rhythm; Disease Models, Animal; DNA Repair; Female; Jet Lag Syndrome; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Period Circadian Proteins; Rats; Rats, Inbred F344; Sirtuin 1 | 2017 |
Inhibition of N-methyl-N-nitrosourea-induced gastric tumorigenesis by Liuwei Dihuang Pill in db/db mice.
Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Carcinogenesis; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Immunohistochemistry; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Ki-67 Antigen; Leptin; Male; Methylnitrosourea; Mice; Stomach Neoplasms | 2017 |
DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage.
Topics: Alkylating Agents; Benzaldehydes; Cell Line, Tumor; Cell Transformation, Neoplastic; Comet Assay; DNA-Activated Protein Kinase; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Golgi Apparatus; Humans; Mammary Glands, Human; Methylation; Methylnitrosourea; Protein Kinase Inhibitors | 2017 |
Interleukin-6 mediates epithelial-stromal interactions and promotes gastric tumorigenesis.
Topics: Animals; Cell Communication; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Culture Media, Conditioned; Disease Models, Animal; Epithelial Cells; Fibroblasts; Humans; Interleukin-6; Methylnitrosourea; Mice; Models, Biological; Neoplastic Stem Cells; STAT3 Transcription Factor; Stomach Neoplasms; Stromal Cells | 2013 |
Recruitment of normal stem cells to an oncogenic phenotype by noncontiguous carcinogen-transformed epithelia depends on the transforming carcinogen.
Topics: Animals; Blotting, Western; Cadmium; Carcinogens; Carcinoma; Cell Line, Tumor; Cell Transformation, Neoplastic; Environmental Pollutants; Epithelial Cells; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Male; Matrix Metalloproteinases; Methylnitrosourea; Mice; Mice, Nude; Neoplastic Stem Cells; Polymerase Chain Reaction; Prostatic Neoplasms; Transforming Growth Factor alpha | 2013 |
Rapamycin and PF4 induce apoptosis by upregulating Bax and down-regulating survivin in MNU-induced breast cancer.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Transformation, Neoplastic; Down-Regulation; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Microtubule-Associated Proteins; Platelet Factor 4; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Survivin; Transcriptional Activation; Up-Regulation | 2014 |
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Disease Progression; DNA Copy Number Variations; Female; Genes, ras; Genomic Instability; Germ-Line Mutation; Humans; Lung Neoplasms; Male; Methylnitrosourea; Mice; Models, Genetic; Mutation; Oncogene Protein p21(ras); Point Mutation; Proto-Oncogene Proteins p21(ras); Urethane | 2015 |
The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Cyclophosphamide; Epithelial Cells; Female; Fluorouracil; Injections, Intraperitoneal; Lymphocytes; Macrophages; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methotrexate; Methylnitrosourea; Rats, Wistar; Thymus Gland; Thymus Neoplasms | 2017 |
c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Transformation, Neoplastic; Drug Resistance; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mitogen-Activated Protein Kinase 8; Stomach Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice.
Topics: Animals; beta Catenin; Carcinogens; Cell Transformation, Neoplastic; Cyclooxygenase 2; Enzyme Activation; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Immunohistochemistry; Intramolecular Oxidoreductases; Methylnitrosourea; Mice; Mice, Transgenic; Microsomes; Prostaglandin-E Synthases; Random Allocation; Stomach Neoplasms | 2008 |
Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity.
Topics: Animals; Calcitriol; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Female; Humans; Hypercalcemia; Incidence; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, SCID; Models, Biological; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Xenograft Model Antitumor Assays | 2008 |
Arsenic-specific stem cell selection during malignant transformation.
Topics: Apoptosis; Arsenites; Blotting, Western; Cadmium Compounds; Carcinogens; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Glutathione; Humans; Immunohistochemistry; Male; Methylnitrosourea; Microscopy, Confocal; Prostate; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Tumor Stem Cell Assay | 2010 |
Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.
Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Disease Models, Animal; DNA Methylation; Female; Gastrins; Gene Expression Regulation, Neoplastic; Gene Silencing; Helicobacter felis; Helicobacter Infections; Histones; Humans; Male; Methylnitrosourea; Mice; Mice, Knockout; Middle Aged; Neoplastic Stem Cells; Peptides; Promoter Regions, Genetic; RNA, Messenger; Stomach Neoplasms; Time Factors; Transfection; Trefoil Factor-1; Tumor Suppressor Proteins | 2011 |
MNU-induced mammary gland carcinogenesis: chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways.
Topics: Animals; Calcitriol; Cell Transformation, Neoplastic; Cholecalciferol; Female; Histocytochemistry; Mammary Neoplasms, Experimental; Methylnitrosourea; Mixed Function Oxygenases; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptors, Calcitriol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis.
Topics: Animals; Biomarkers; Caspase 3; Cell Transformation, Neoplastic; Diet; Enzyme Activation; Fatty Acids; Female; Fish Oils; Glutathione; Glutathione Peroxidase; Ki-67 Antigen; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Oxidative Stress; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Tamoxifen; Time Factors | 2011 |
Effects of short-term estrogen treatment on the progression of N-methyl-N-nitrosourea-induced premalignant mammary lesions in female Lewis rats.
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Cyclin D1; Estrogens; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Precancerous Conditions; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred Lew | 2011 |
Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Forkhead Box Protein M1; Forkhead Transcription Factors; Gastric Mucosa; Genotype; Humans; Integrases; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microfilament Proteins; Neoplastic Stem Cells; Phenotype; Precancerous Conditions; Promoter Regions, Genetic; Pyloric Antrum; Stomach Neoplasms; Time Factors | 2012 |
[Influence of sodium selenite on carcinogenesis of the prostate and other organs induced by methylnitrosourea and testosterone in rats].
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Drinking Water; Lymphoma; Male; Methylnitrosourea; Orchiectomy; Precancerous Conditions; Prostatic Hyperplasia; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Rats; Rats, Wistar; Sodium Selenite; Testosterone | 2011 |
Effects of energy restriction and wheel running on mammary carcinogenesis and host systemic factors in a rat model.
Topics: Alkylating Agents; Animals; Biomarkers, Tumor; C-Reactive Protein; Caloric Restriction; Cell Transformation, Neoplastic; Female; Insulin-Like Growth Factor I; Interleukin-6; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Running; Signal Transduction; Tumor Necrosis Factor-alpha | 2012 |
MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cytochromes c; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Animal; Methylnitrosourea; Mice; Mice, Inbred BALB C; MicroRNAs; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous | 2012 |
The role of LEF1 in endometrial gland formation and carcinogenesis.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Cyclin D1; Endometrial Neoplasms; Endometrium; Estrous Cycle; Female; Gene Expression Regulation, Developmental; Humans; Lymphoid Enhancer-Binding Factor 1; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Middle Aged | 2012 |
Fish oil alters tamoxifen-modulated expression of mRNAs that encode genes related to differentiation, proliferation, metastasis, and immune response in rat mammary tumors.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; Corn Oil; Dietary Fats; Female; Fish Oils; Gene Expression Regulation, Neoplastic; Immunity; Mammary Neoplasms, Experimental; Methylnitrosourea; Polymerase Chain Reaction; Rats; Reproducibility of Results; RNA, Messenger; Tamoxifen; Transcriptome | 2012 |
Rosiglitazone shows partial oncostatic effect in rat mammary carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Glycemic Index; Hypoglycemic Agents; Insulin; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones | 2013 |
Defining the role of histone deacetylases in the inhibition of mammary carcinogenesis by dietary energy restriction (DER): effects of suberoylanilide hydroxamic acid (SAHA) and DER in a rat model.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Caloric Restriction; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Vorinostat | 2013 |
Inhibitory effects of 17beta-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Genetically Modified; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Estradiol; Female; Gene Transfer Techniques; Genes, ras; Genetic Predisposition to Disease; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Phenols; Proto-Oncogene Mas; Rats; Tumor Cells, Cultured | 2002 |
Prevention by intrarectal 5-aminosalicylic acid of N-methylnitrosourea-induced colon cancer in F344 rats.
Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Transformation, Neoplastic; Colonic Neoplasms; Female; Mesalamine; Methylnitrosourea; Rats; Rats, Inbred F344 | 2003 |
The stroma as a crucial target in rat mammary gland carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Extracellular Matrix; Female; Genes, ras; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mutation; Neoplasm Transplantation; Rats; Rats, Inbred WF; Stromal Cells | 2004 |
Watch thy neighbor: cancer is a communal affair.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Extracellular Matrix; Female; Genes, ras; Mammary Neoplasms, Experimental; Methylnitrosourea; Mutation; Neoplasm Transplantation; Rats; Rats, Inbred WF; Stromal Cells | 2004 |
Frequent activation of CArG binding factor-A expression and binding in N-methyl-N-nitrosourea-induced rat mammary carcinomas.
Topics: Alkylating Agents; Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; DNA Mutational Analysis; DNA-Binding Proteins; Female; Gene Expression Profiling; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Inbred F344; Repressor Proteins; Ribonucleoproteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription Factors | 2004 |
Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats.
Topics: Animals; Blotting, Western; Brain; Carcinogens; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Growth Substances; Methylnitrosourea; Neuroglia; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Receptors, Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells | 2004 |
Effects of dietary energy repletion and IGF-1 infusion on the inhibition of mammary carcinogenesis by dietary energy restriction.
Topics: Animals; Blood Glucose; Caloric Restriction; Carcinogens; Cell Transformation, Neoplastic; Corticosterone; Energy Intake; Female; Glucose; Growth Hormone; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Sprague-Dawley | 2005 |
Susceptibility of Lobund-Wistar x Copenhagen hybrid rats to autochthonous prostate carcinogenesis.
Topics: Adenocarcinoma; Animals; Carcinogens; Cell Transformation, Neoplastic; Chimera; Disease Models, Animal; Genetic Predisposition to Disease; Gonadal Steroid Hormones; Male; Methylnitrosourea; Neoplasm Transplantation; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Testosterone | 2005 |
Enhancement by acrylamide of N-methyl-N-nitrosourea-induced rat mammary tumor development-possible application for a model to detect co-modifiers of carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acrylamide; Administration, Oral; Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Interactions; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Nitrosamines; Rats; Rats, Sprague-Dawley; Thyroid Neoplasms | 2005 |
Genistein enhances N-nitrosomethylurea-induced rat mammary tumorigenesis.
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Estradiol; Estrous Cycle; Female; Genistein; Mammary Neoplasms, Animal; Methylnitrosourea; Organ Size; Phytoestrogens; Rats; Rats, Sprague-Dawley | 2006 |
Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanism.
Topics: Adjuvants, Immunologic; Alkylating Agents; Animals; Breast Neoplasms; Carcinoma in Situ; Cell Transformation, Neoplastic; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Dehydroepiandrosterone; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53 | 2005 |
High salt diets dose-dependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cells.
Topics: Adenocarcinoma; Amino Acid Sequence; Animal Feed; Animals; Base Sequence; Body Weight; Cell Transformation, Neoplastic; Cloning, Molecular; Conserved Sequence; Dose-Response Relationship, Drug; Gastric Mucosa; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitrosourea; Molecular Sequence Data; Mongolia; Mucins; Sequence Alignment; Sodium Chloride; Stomach Neoplasms | 2006 |
Loss of chromosomal integrity drives rat mammary tumorigenesis.
Topics: Animals; Antigens, Neoplasm; Aurora Kinase A; Aurora Kinases; Carcinoma; Cell Transformation, Neoplastic; Centrosome; Chromosomal Instability; Female; Karyotyping; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Transplantation; Polyploidy; Protein Serine-Threonine Kinases; Rats; Rats, Inbred WF | 2007 |
Protective effect of Acticoa powder, a cocoa polyphenolic extract, on prostate carcinogenesis in Wistar-Unilever rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Body Weight; Cacao; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Disease Models, Animal; Flavonoids; Male; Methylnitrosourea; Phenols; Plant Extracts; Polyphenols; Prostatic Neoplasms; Rats; Rats, Wistar; Testosterone Propionate | 2008 |
Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Caco-2 Cells; Carcinogens; Caseins; Cell Transformation, Neoplastic; Cerulenin; Colon; Dietary Proteins; DNA Damage; Down-Regulation; Epithelial Cells; Fatty Acid Synthase, Type I; Fatty Acid Synthases; Fatty Acid Synthesis Inhibitors; Female; Humans; Hydrocarbons, Fluorinated; Insulin; Male; Methylnitrosourea; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Soybean Proteins; Sulfonamides; Transfection; Tumor Suppressor Protein p53 | 2008 |
Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromosome Mapping; Cloning, Molecular; Cricetinae; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; Genetic Linkage; Hybrid Cells; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Oncogenes; Thymus Neoplasms | 1984 |
[Viruses as co-factors in chemical carcinogenesis (author's transl)].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Humans; Leukemia Virus, Murine; Leukemia, Experimental; Methylnitrosourea; Mice; Rats; Retroviridae | 1981 |
Cytochemical markers of bladder carcinogenesis.
Topics: 5'-Nucleotidase; 9,10-Dimethyl-1,2-benzanthracene; Alkaline Phosphatase; Animals; Cell Membrane; Cell Transformation, Neoplastic; Female; Methylnitrosourea; Mice; Mice, Inbred C57BL; Microscopy, Electron; Neoplasms, Experimental; Nucleotidases; Organ Culture Techniques; Rats; Rats, Inbred Strains; Urinary Bladder; Urinary Bladder Neoplasms | 1981 |
Mammary carcinogenesis in rats in relation to age at time of N-nitroso-N-methylurea administration.
Topics: Aging; Animals; Cell Transformation, Neoplastic; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Inbred Strains | 1983 |
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Guanine; Methylnitrosourea; Neoplasms, Experimental | 1984 |
Chemical carcinogens transform BHK cells by inducing a recessive mutation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Genes, Recessive; Hybrid Cells; Kinetics; Mesocricetus; Methylnitrosourea; Mutation; Phenotype | 1982 |
Ultrastructural differences between control and nitrosomethylurea-transformed cells of rat hepatocyte origin.
Topics: Animals; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasm; Cytoplasmic Granules; Endoplasmic Reticulum; Golgi Apparatus; Lactates; Lactic Acid; Liver; Methylnitrosourea; Mitochondria; Rats | 1982 |
The kinetics of the protective effect of beta-sitosterol against MNU-induced colonic neoplasia.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; DNA; Kinetics; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Sitosterols | 1982 |
Morphological transformation of C3H/10T1/2 CL8 cells by alkylating agents.
Topics: Alkylating Agents; Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Drug Evaluation, Preclinical; Hydrocarbons, Iodinated; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Propiolactone; Thiophenes | 1981 |
An in vitro model of pancreas carcinogenesis: two-stage MNU--TPA effect.
Topics: Animals; Cell Transformation, Neoplastic; Hyperplasia; Methylnitrosourea; Mice; Mice, Nude; Models, Biological; Necrosis; Neoplasm Transplantation; Nitrosourea Compounds; Organ Culture Techniques; Pancreas; Pancreatic Neoplasms; Phorbols; Rats; Tetradecanoylphorbol Acetate; Transplantation, Heterologous | 1980 |
Enhancement of transformation in vitro of a nontumorigenic rat urothelial cell line by interleukin 6.
Topics: Animals; Antigens, CD; Carcinogens; Carcinoma; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Gene Expression Regulation, Neoplastic; In Vitro Techniques; Interleukin-1; Interleukin-6; Interleukin-8; Methylnitrosourea; Rats; Receptors, Interleukin; Receptors, Interleukin-6; RNA, Messenger; RNA, Neoplasm; Tumor Necrosis Factor-alpha; Urinary Bladder; Urinary Bladder Neoplasms | 1995 |
Refractoriness to mammary carcinogenesis in the parous mouse is reversible by hormonal stimulation induced by pituitary isografts.
Topics: Adenocarcinoma; Animals; Cell Differentiation; Cell Transformation, Neoplastic; Disease Susceptibility; Female; Humans; Infant, Newborn; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mitogens; Parity; Pituitary Gland; Pregnancy; Pregnancy Complications, Neoplastic; Pregnancy, Animal; Progesterone; Prolactin | 1995 |
Influence of ethanol intake on mammary gland morphology and cell proliferation in normal and carcinogen-treated rats.
Topics: Alcohol Drinking; Animals; Cell Division; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA Replication; Estradiol; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Progesterone; Rats; Rats, Sprague-Dawley | 1994 |
In vitro carcinogenesis of hamster pancreatic duct cells: cellular and molecular alterations.
Topics: Animals; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Gene Expression; Genes, ras; Mesocricetus; Methylnitrosourea; Molecular Sequence Data; Mutation; Nitrosourea Compounds; Pancreatic Ducts; Pancreatic Neoplasms; Time Factors; Transforming Growth Factor alpha | 1994 |
Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Transformation, Neoplastic; Genes, ras; Humans; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Proteins; Point Mutation | 1994 |
Pituitary-isografted mice are highly susceptible to MNU-induced mammary carcinogenesis irrespective of the level of alveolar differentiation.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Pituitary Gland; Transplantation, Heterotopic; Transplantation, Isogeneic | 1994 |
In vitro carcinogenesis of mammary epithelial cells by N-nitroso-N-methylurea using a collagen gel matrix culture.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley | 1993 |
Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea.
Topics: Adenomatous Polyposis Coli; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chromosome Aberrations; Gene Deletion; Genes, DCC; Humans; Keratinocytes; Methylnitrosourea; Papillomaviridae | 1993 |
Interaction of HPV-18 and nitrosomethylurea in the induction of squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Cocarcinogenesis; DNA, Viral; Humans; Keratinocytes; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Papillomaviridae; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Tumorigenesis of rat mammary epithelial cells by N-nitroso-N-methylurea in an in vitro system: characterization of the microtumors.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Cell Transformation, Neoplastic; DNA; Epithelium; Female; Mammary Glands, Animal; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tumor Cells, Cultured | 1996 |
Transformation in vitro of a nontumorigenic rat urothelial cell line by hydrogen peroxide.
Topics: Animals; Carcinoma, Transitional Cell; Cell Division; Cell Transformation, Neoplastic; Cystitis; Cytokines; Hydrogen Peroxide; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Rats; Tumor Cells, Cultured; Tumor Stem Cell Assay; Urinary Bladder Neoplasms | 1996 |
Malignant transformation of human prostate epithelial cells by N-nitroso-N-methylurea.
Topics: Adult; Animals; Carcinogens; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Disorders; Humans; Karyotyping; Male; Methylnitrosourea; Mice; Mice, Nude; Neoplasm Proteins; Prostate; ras Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Transformation in vitro of a nontumorigenic rat urothelial cell line by tumor necrosis factor-alpha.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Hydrogen Peroxide; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Rats; Tumor Necrosis Factor-alpha; Vitamin E | 1997 |
Telomerase activity in the normal and neoplastic rat mammary gland.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Epithelium; Female; Male; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Phenotype; Pregnancy; Rats; Rats, Inbred Strains; Telomerase | 1997 |
Interleukin-6 and epidermal growth factor promote anchorage-independent growth of immortalized human prostatic epithelial cells treated with N-methyl-N-nitrosourea.
Topics: Cell Adhesion; Cell Culture Techniques; Cell Division; Cell Line; Cell Transformation, Neoplastic; Epidermal Growth Factor; Epithelial Cells; Humans; Interleukin-6; Kinetics; Male; Methylnitrosourea; Prostate; Receptors, Interleukin-6; Time Factors | 1998 |
Microsatellite instability in an animal model of mammary carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; DNA Repair; Female; Genetic Markers; Mammary Neoplasms, Experimental; Methylnitrosourea; Microsatellite Repeats; Rats; Rats, Sprague-Dawley | 1998 |
Defective retrovirus insertion activates c-Ha-ras protooncogene in an MNU-induced rat mammary carcinoma.
Topics: 3T3 Cells; Animals; Base Sequence; Cell Transformation, Neoplastic; Defective Viruses; Exons; Female; Genes, env; Genes, ras; Introns; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Proto-Oncogene Proteins p21(ras); Rats; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Retroviridae; Transfection | 1998 |
A short-term assessment of tumor-promotion activity in the livers of rats treated with two genotoxic methylating agents: dimethylnitrosamine and methylnitrosourea.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Dimethylnitrosamine; DNA Replication; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344 | 1998 |
Morphological changes of epithelial rests of Malassez in rat molars induced by local administration of N-methylnitrosourea.
Topics: Alginates; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Dental Impression Materials; Epithelial Cells; Male; Mandible; Mandibular Neoplasms; Methylnitrosourea; Molar; Odontogenic Tumors; Periodontal Ligament; Random Allocation; Rats; Rats, Wistar; Time Factors | 1998 |
The cellular ecology of progressive neoplastic transformation: a clonal analysis.
Topics: 3T3 Cells; Animals; Carcinogens; Cell Culture Techniques; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Clone Cells; Kinetics; Methylnitrosourea; Mice | 1999 |
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Codon; DNA Adducts; DNA Damage; DNA Methylation; Genes, ras; Guanine; Humans; Lac Operon; Lymphoma; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Organ Specificity; Point Mutation; Spleen; Thymus Gland; Thymus Neoplasms; Transgenes | 1999 |
Multiple pathways of prostate carcinogenesis analyzed by using cultured cells isolated from rats treated with N-methyl-N-nitrosourea and testosterone.
Topics: Animals; Base Sequence; Cell Adhesion; Cell Transformation, Neoplastic; Cells, Cultured; DNA Primers; Genes, ras; Genotype; Male; Methylnitrosourea; Mutation; Phenotype; Prostate; Prostatic Neoplasms; Rats; Species Specificity; Testosterone | 1999 |
Isolation of oncogenes from rat mammary tumors by a highly efficient retrovirus expression cloning system.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Cloning, Molecular; Codon; Female; Genes, ras; Genetic Vectors; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Point Mutation; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; Retroviridae; Transfection | 1999 |
Reasons it is doubtful that preconceptional paternal irradiation with plutonium-239 had any effect on cancer induction by methyl-nitroso-urea.
Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; DNA Damage; Male; Methylnitrosourea; Mice; Neoplasms; Paternal Exposure; Plutonium; Reproducibility of Results | 1999 |
Oncogenic potential of cyclin E in T-cell lymphomagenesis in transgenic mice: evidence for cooperation between cyclin E and Ras but not Myc.
Topics: Animals; Cell Transformation, Neoplastic; Cyclin E; Embryo, Mammalian; Fibroblasts; Genes, myc; Genes, ras; Hyperplasia; Ionomycin; Locus Control Region; Lymphoid Tissue; Lymphoma, T-Cell; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Point Mutation; Protamine Kinase; Rats; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thymus Gland | 1999 |
Neoplastic transformation of mammary epithelial cells in rats is associated with decreased apoptotic cell death.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma in Situ; Carcinoma, Ductal, Breast; Cell Division; Cell Transformation, Neoplastic; Epithelial Cells; Female; Hyperplasia; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Necrosis; Precancerous Conditions; Rats; Rats, Sprague-Dawley | 2000 |
TCR v(beta) repertoire restriction and lack of CDR3 conservation implicate TCR-superantigen interactions in promoting the clonal evolution of murine thymic lymphomas.
Topics: Animals; Antigens, Neoplasm; Antigens, Viral; Cell Transformation, Neoplastic; Clonal Deletion; Cocarcinogenesis; Complementarity Determining Regions; Endogenous Retroviruses; Female; Gammaretrovirus; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Genes, bcl-2; Immunoglobulin Variable Region; Lymphoma; Male; Membrane Glycoproteins; Methylnitrosourea; Mice; Mice, Inbred AKR; Neoplasm Proteins; Precancerous Conditions; Proto-Oncogene Proteins c-bcl-2; Receptors, Antigen, T-Cell, alpha-beta; Superantigens; Thymus Neoplasms | 2000 |
Effect of intact and isoflavone-depleted soy protein on NMU-induced rat mammary tumorigenesis.
Topics: Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Female; Isoflavones; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Inbred F344; Soybean Proteins | 2000 |
Effect of dietary fatty acids on tumorigenesis of colon cancer induced by methyl nitrosourea in rats.
Topics: Alkaline Phosphatase; Animals; Body Weight; Cell Cycle; Cell Transformation, Neoplastic; Colonic Neoplasms; Diet; Dietary Fats; Dinoprostone; Fatty Acids; Intestinal Mucosa; Male; Membrane Fluidity; Methylnitrosourea; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Testis | 2000 |
Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination.
Topics: Alleles; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Codon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Genes, p53; Guanine; Homozygote; Humans; Loss of Heterozygosity; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Transcriptional Activation | 2000 |
Effect of dietary fatty acids on colon tumorigenesis induced by methyl nitrosourea in rats.
Topics: Alkylating Agents; Animals; Cell Division; Cell Transformation, Neoplastic; Colonic Neoplasms; Dietary Fats; Disease Models, Animal; Fatty Acids; Fish Oils; Infusions, Parenteral; Male; Methylnitrosourea; Rats; Rats, Sprague-Dawley | 2000 |
Detection of VIP receptors in MNU-induced breast cancer in rats: implications for breast cancer targeting.
Topics: Alkylating Agents; Animals; Breast Neoplasms; Cell Transformation, Neoplastic; Female; Fluorescein; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Receptors, Vasoactive Intestinal Peptide | 2001 |
Antitumoral effect of recombinant mistletoe lectin on chemically induced urinary bladder carcinogenesis in a rat model.
Topics: Adjuvants, Immunologic; Administration, Intravesical; Alkylating Agents; Animals; Cell Transformation, Neoplastic; Female; Methylnitrosourea; Neoplasms, Experimental; Plant Preparations; Plant Proteins; Rats; Recombinant Proteins; Ribosome Inactivating Proteins, Type 2; Toxins, Biological; Urinary Bladder Neoplasms; Urothelium | 2001 |
Histogenesis of pseudo-ductular changes induced in the pancreas of guinea pigs treated with N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Cytoplasmic Granules; Dilatation, Pathologic; Female; Guinea Pigs; Male; Methylnitrosourea; Microscopy, Electron; Organelles; Pancreas; Pancreatic Neoplasms; Precancerous Conditions | 1980 |
Methylnitrosourea induction of thymomas in AKR mice requires one or two "hits" only.
Topics: AKR murine leukemia virus; Animals; Carcinogens; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; Female; Methylnitrosourea; Mice; Mice, Inbred AKR; Oncogenes; Thymoma; Thymus Neoplasms | 1980 |
Characterization of initiated cells in N-methylnitrosourea-induced carcinogenesis of the CNS in the adult rat.
Topics: Animals; Cell Culture Techniques; Cell Transformation, Neoplastic; Central Nervous System; Central Nervous System Neoplasms; Immunohistochemistry; Karyotyping; Male; Methylnitrosourea; Mice; Models, Animal; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 2001 |
Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcinogens; Cell Division; Cell Transformation, Neoplastic; DNA Mutational Analysis; Female; Guanine; Humans; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Knockout; Mice, Transgenic; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Single-Stranded Conformational; RNA, Messenger; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 2001 |
High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Genetically Modified; Carcinogens; Cell Transformation, Neoplastic; Female; Genes, ras; Genetic Predisposition to Disease; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Mas; Rats | 2001 |
Modulatory effects of neonatal exposure to TCDD, or a mixture of PCBs, p,p'-DDT, and p-p'-DDE, on methylnitrosourea-induced mammary tumor development in the rat.
Topics: Alkylating Agents; Animals; Breast; Cell Transformation, Neoplastic; DDT; Dichlorodiphenyl Dichloroethylene; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Insecticides; Mammary Neoplasms, Experimental; Methylnitrosourea; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2001 |
Cell susceptibility to the cytotoxic effect of the carcinogens dimethylnitrosamine and N-nitrosomethylurea.
Topics: Animals; Carcinogens; Cell Line, Transformed; Cell Transformation, Neoplastic; Clone Cells; Cricetinae; Dimethylnitrosamine; Methylnitrosourea | 1970 |
Evaluation of the chemopreventive potential of retinoids using a novel in vitro human prostate carcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Cell Adhesion; Cell Line, Transformed; Cell Transformation, Neoplastic; Chemoprevention; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Male; Methylnitrosourea; Mice; Mice, Nude; Mutagenicity Tests; Neoplasm Transplantation; Phenotype; Prostatic Neoplasms; Retinoids; Tumor Cells, Cultured | 2001 |
Specific aneusomies in Chinese hamster cells at different stages of neoplastic transformation, initiated by nitrosomethylurea.
Topics: Alkylating Agents; Aneuploidy; Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Cricetulus; Male; Methylnitrosourea; Time Factors | 2002 |
Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoviridae; Animals; Antiviral Agents; beta-Galactosidase; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Ganciclovir; Gene Expression Regulation, Developmental; Immunoenzyme Techniques; Incidence; Injections, Intralesional; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Inbred WF; Thymidine Kinase | 2002 |
Thymosin alpha1 inhibits mammary carcinogenesis in Fisher rats.
Topics: Animals; Blood Chemical Analysis; Cell Transformation, Neoplastic; Female; Leukocyte Count; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Inbred F344; Thymalfasin; Thymosin | 2002 |
Neoplastic transformation of rat mammary cells exposed to 7,12-dimethylbenz[alpha]anthracene or N-nitrosomethylurea in cell culture.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Benz(a)Anthracenes; Cell Transformation, Neoplastic; Cells, Cultured; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Nitrosourea Compounds; Rats | 1978 |
[Histochemistry of acid mucopolysaccharides during the genesis of brain tumors induced in the rat by methyl-nitrosourea (author's transl)].
Topics: Animals; Brain Neoplasms; Cell Transformation, Neoplastic; Glioma; Glycosaminoglycans; Histocytochemistry; Male; Methylnitrosourea; Neurilemmoma; Rats; Sarcoma; Time Factors | 1978 |
[Long-term cultures of experimental CNS tumours as models in neurooncological research (author's transl)].
Topics: Animals; Brain Neoplasms; Bucladesine; Cell Division; Cell Transformation, Neoplastic; Culture Techniques; Ethylnitrosourea; Glioma; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Rats; Rats, Inbred Strains; Time Factors | 1976 |
Growth of murine sarcoma virus-transformed rat kidney cells in nude mice: absence of induction of host endogenous viruses.
Topics: Animals; Capsid; Cell Line; Cell Transformation, Neoplastic; Helper Viruses; Kidney Neoplasms; Methylnitrosourea; Mice; Mice, Nude; Neoplasm Transplantation; Nitrosourea Compounds; Rats; Retroviridae; Sarcoma, Experimental; Transplantation, Heterologous; Tumor Virus Infections; Virus Replication | 1977 |
Enhancement of biochemical transformation of mammalian cells by herpes simplex virus following nitrosomethylurea treatment.
Topics: Animals; Cell Transformation, Neoplastic; DNA Repair; Methylnitrosourea; Mice; Nitrosourea Compounds; Phenotype; Simplexvirus; Thymidine Kinase; Time Factors | 1979 |
[In vitro malignant transformation of fetal hamster brain cells by methylnitrosourea].
Topics: Animals; Brain; Brain Neoplasms; Cell Transformation, Neoplastic; Cricetinae; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neuroglia; Nitrosourea Compounds | 1977 |
Unique protein in the nucleus of a cell line transformed by the carcinogen methylnitrosourea.
Topics: Animals; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Haplorhini; Methylnitrosourea; Neoplasm Proteins; Nitrosourea Compounds; Nucleoproteins | 1975 |
Chemical transformation of Chinese hamster cells. I. A comparison of some properties of transformed cells.
Topics: Benz(a)Anthracenes; Carcinogens; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Methylcholanthrene; Methylnitrosourea | 1976 |
Nitrosomethylurea-induced lymphomas in thymectomized mice, in relation to thymus-dependent and independent systems.
Topics: Adenoma; Animals; Cell Transformation, Neoplastic; Female; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Rats; T-Lymphocytes; Thymectomy; Thymus Neoplasms | 1975 |
Proliferation of hemopoietic stem cells and development of potentially leukemic cells in vitro.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Colony-Stimulating Factors; Female; Granulocytes; Hematopoietic Stem Cells; Leukemia, Experimental; Macrophages; Male; Methylnitrosourea; Mice | 1975 |
Spontaneous and chemically induced transformation of rat embryo cell cultures.
Topics: Animals; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Embryo, Mammalian; Fibrosarcoma; Male; Methylnitrosourea; Neoplasm Transplantation; Rats; Sarcoma, Experimental; Time Factors; Transplantation, Isogeneic | 1975 |
Temperature sensitive cells in the study of carcinogenic transformation.
Topics: Cell Fusion; Cell Line; Cell Nucleus; Cell Transformation, Neoplastic; Clone Cells; DNA, Neoplasm; Leucine; Methylnitrosourea; Mitosis; Neoplasm Proteins; Nitrosourea Compounds; RNA, Neoplasm; Temperature; Thymidine; Uridine | 1975 |
Molecular mechanism of in vitro transformation of mammalian cells by chemical carcinogens.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Clone Cells; Cricetinae; Drug Evaluation, Preclinical; Methylnitrosourea; Mice; Mice, Inbred C3H; Models, Biological; Mutagens; Nitroquinolines; Phenotype; Temperature | 1975 |
The effect produced by some carcinogenic nitrosocompounds on organ cultures from human embryonic lung and kidney tissues.
Topics: Azo Compounds; Cell Transformation, Neoplastic; Cells, Cultured; Dimethylnitrosamine; Epithelial Cells; Epithelium; Humans; Hyperplasia; Kidney; Lung; Methylnitrosourea; Necrosis; Nitrosamines; Nitrosourea Compounds; o-Aminoazotoluene; Organ Culture Techniques; Time Factors | 1975 |
[Growth kinetics of transplantable mammary gland tumors in mice].
Topics: Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Ethylnitrosourea; Kinetics; Male; Mammary Neoplasms, Experimental; Mathematics; Methylnitrosourea; Mice; Mice, Inbred A; Mice, Inbred C3H; Neoplasm Transplantation; Nitrosourea Compounds; Time Factors | 1975 |
Mutational activation of H-ras oncogene transformability by alkylnitrosourea-induced DNA damage.
Topics: 3T3 Cells; Alkylation; Animals; Base Sequence; Cell Transformation, Neoplastic; DNA; DNA Damage; Ethylnitrosourea; Gene Expression Regulation; Genes, ras; Methylnitrosourea; Mice; Molecular Sequence Data; Mutation | 1992 |
Ras gene mutation-independent tumours in the intestine of the rat by a single dose of N-methyl-N-nitrosourea.
Topics: Animals; Cell Transformation, Neoplastic; Gene Amplification; Genes, ras; Ileal Neoplasms; Ileum; Intestinal Neoplasms; Jejunal Neoplasms; Jejunum; Male; Methylnitrosourea; Mutation; Rats; Rats, Inbred Strains | 1992 |
Variant protein patterns in hepatomas and transformed liver cell lines as determined by high resolution two-dimensional gel electrophoresis (2DE).
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Electrophoresis, Gel, Two-Dimensional; Glutathione Transferase; Hydroxyurea; Isoelectric Focusing; Isoenzymes; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Methylnitrosourea; Neoplasm Proteins; Precancerous Conditions; Proteins; Rats; Rats, Inbred Strains | 1992 |
Detection of transforming oncogenes in rat colon tumors induced by direct perfusion with N-methyl-N-nitrosourea.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Colonic Neoplasms; Genes, ras; Male; Methylnitrosourea; Mice; Mice, Nude; Oncogenes; Perfusion; Rats; Rats, Inbred F344 | 1992 |
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylhydrazines; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines | 1991 |
Amplification and activation of c-Ki-ras oncogene in cell line developed from human pancreas explants.
Topics: Animals; Blotting, Southern; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Methylnitrosourea; Nucleic Acid Hybridization; Pancreas; Pancreatic Neoplasms | 1991 |
Inactivity of acrylonitrile epoxide to modify a Ha-ras DNA in a non-focus transfection-transformation assay.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Blotting, Southern; Carcinogens; Cell Line; Cell Transformation, Neoplastic; DNA; Ethylene Oxide; Genes, ras; Humans; Methylnitrosourea; Plasmids; Proto-Oncogene Mas; Transfection; Transformation, Genetic | 1991 |
Differential growth factor expression in transformed mouse NIH-3T3 cells.
Topics: Animals; Blotting, Northern; Cell Line, Transformed; Cell Transformation, Neoplastic; Cell Transformation, Viral; Culture Media; ErbB Receptors; Fibroblast Growth Factors; Gene Expression Regulation, Neoplastic; Growth Substances; Methylnitrosourea; Mice; Oncogenes; Platelet-Derived Growth Factor; Poly A; RNA, Messenger; Simian virus 40; Transforming Growth Factors | 1990 |
Transforming c-Ki-ras mutation is a preneoplastic event in mouse mammary carcinogenesis induced in vitro by N-methyl-N-nitrosourea.
Topics: Animals; Base Sequence; Blotting, Southern; Cell Transformation, Neoplastic; Cells, Cultured; DNA Probes; Female; Genes, ras; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Polymerase Chain Reaction; Precancerous Conditions; Restriction Mapping | 1990 |
Activation of ras oncogenes preceding the onset of neoplasia.
Topics: Adenofibroma; Animals; Animals, Newborn; Base Sequence; Carcinoma; Cell Transformation, Neoplastic; Estrogens; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Rats; Rats, Inbred Strains; Sexual Maturation; Time Factors | 1990 |
Cellular ras protooncogene expression in human mammary explant cultures. A potential marker for chemical carcinogenesis.
Topics: Adult; Benzo(a)pyrene; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Transformation, Neoplastic; Cells, Cultured; Female; Genes, ras; Humans; Methylnitrosourea; Middle Aged; Organ Specificity; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras) | 1990 |
Characterization of an N-methyl-N-nitrosourea-induced autochthonous rat bladder cancer model.
Topics: Animals; Carcinoma, Transitional Cell; Cell Transformation, Neoplastic; Chromosome Aberrations; Disease Models, Animal; FANFT; Female; Methylnitrosourea; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1990 |
In vitro malignant conversion of low-grade rat urinary bladder carcinoma cells by exposure to N-methyl-N-nitrosourea.
Topics: Animals; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Clone Cells; Codon; Dose-Response Relationship, Drug; Genes, ras; Methylnitrosourea; Mice; Mutation; Neoplasm Invasiveness; Neoplasm Transplantation; Oncogene Protein p21(ras); Plasminogen Activators; Rats; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1990 |
Neoplastic transformation and DNA damage of mouse mammary epithelial cells by N-methyl-N'-nitrosourea in organ culture.
Topics: Animals; Cell Transformation, Neoplastic; DNA Damage; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Organ Culture Techniques | 1990 |
Specific patterns of oncogene activation in transplacentally induced tumors.
Topics: Animals; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA, Neoplasm; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, ras; Maternal-Fetal Exchange; Methylnitrosourea; Mice; Molecular Sequence Data; Neoplasms, Experimental; Oligonucleotide Probes; Oncogenes; Placenta; Polymerase Chain Reaction; Pregnancy; Rats; Rats, Inbred BUF; Transfection | 1990 |
Multistage transformation of cultured rat urothelium: the effects of N-methyl-N-nitrosourea, sodium saccharin, sodium cyclamate and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Cyclamates; Epithelium; Female; Hyperplasia; Methylnitrosourea; Phenotype; Rats; Rats, Inbred F344; Saccharin; Tetradecanoylphorbol Acetate; Urinary Bladder | 1986 |
Properties of N-methyl-N-nitrosourea-resistant, Mex- derivatives of an SV40-immortalized human fibroblast cell line.
Topics: Carcinogens; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Drug Resistance; Fibroblasts; Humans; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Simian virus 40; Transfection | 1989 |
Molecular mechanisms of alkylation sensitivity in Indian muntjac cell lines.
Topics: Alkylating Agents; Alkylation; Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromosome Aberrations; Deer; DNA Damage; Kinetics; Methylnitrosourea; Simian virus 40; Sister Chromatid Exchange; Sulfuric Acid Esters; Sulfuric Acids | 1989 |
Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Codon; DNA, Neoplasm; Exons; Gene Amplification; Gene Expression Regulation; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Inbred A; Mutation; Nucleic Acid Hybridization; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Transfection | 1989 |
Immunohistochemistry and cytochemistry of experimental rat bladder cancer: binding of the lectins PNA and WGA and of a Le(Y) mouse monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Antigens, Tumor-Associated, Carbohydrate; Arachis; Carcinoma, Transitional Cell; Cell Transformation, Neoplastic; Female; Immunohistochemistry; Lectins; Lewis Blood Group Antigens; Methylnitrosourea; Peanut Agglutinin; Plant Lectins; Rats; Rats, Inbred Strains; Urinary Bladder Neoplasms; Wheat Germ Agglutinins | 1989 |
beta-Carotene reduces sister chromatid exchanges induced by chemical carcinogens in mouse mammary cells in organ culture.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; beta Carotene; Carcinogens; Carotenoids; Cell Transformation, Neoplastic; Diethylnitrosamine; Female; Fenretinide; Mammary Glands, Animal; Methylnitrosourea; Mice; Organ Culture Techniques; Retinoids; Sister Chromatid Exchange; Tretinoin | 1985 |
Transformation sensitivity in early S-phase and clonogenic potential are target-cell characteristics in liver carcinogenesis by N-methyl-N-nitrosourea.
Topics: Adenosine Triphosphatases; Animals; Cell Division; Cell Transformation, Neoplastic; Hepatectomy; Interphase; Liver Neoplasms; Male; Methylnitrosourea; Rats; Rats, Inbred Strains | 1987 |
Induction of thymomas by N-methyl-N-nitrosourea in AKR mice: interaction between the chemical carcinogen and endogenous murine leukaemia viruses.
Topics: Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; DNA Restriction Enzymes; Kinetics; Leukemia Virus, Murine; Methylnitrosourea; Mice; Thymoma; Thymus Neoplasms; Transfection | 1987 |
Morphological transformation of immortalized hamster dermal fibroblasts following treatment with simple alkylating carcinogens.
Topics: Alkylating Agents; Animals; Cell Division; Cell Transformation, Neoplastic; Cricetinae; DNA; DNA Damage; Ethylnitrosourea; Genes, ras; Methylnitrosourea; Mice; Mice, Nude; Neoplasms, Experimental; Sulfuric Acid Esters | 1988 |
In vitro transformation of mouse mammary epithelial cells grown serum-free inside collagen gels.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blood Physiological Phenomena; Cell Transformation, Neoplastic; Cells, Cultured; Collagen; Epithelium; Female; Gels; Hyperplasia; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C | 1987 |
Expression of phenotypical changes by human breast epithelial cells treated with carcinogens in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adolescent; Adult; Animals; Antigens, Neoplasm; Breast; Cell Transformation, Neoplastic; Cells, Cultured; Cytochalasin B; Epithelium; Female; Humans; Karyotyping; Lectins; Male; Membrane Glycoproteins; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mucin-1; Oncogenes; Phenotype | 1988 |
Nuclear phenotypical changes of human breast epithelial cells treated with carcinogens.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adult; Breast; Cell Nucleolus; Cell Nucleus; Cell Transformation, Neoplastic; Cells, Cultured; Chromatin; Female; Humans; Methylnitrosourea; Nitroquinolines; Phenotype | 1987 |
Differentiation-induced ML-1 cells as targets for transformation by a chemical carcinogen.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA; Female; Humans; Leukemia, Myeloid, Acute; Methylnitrosourea; Mice; Mice, Nude | 1988 |
Concomitant K- and N-ras gene point mutations in clonal murine lymphoma.
Topics: Alleles; Animals; Cell Transformation, Neoplastic; DNA, Neoplasm; Lymphoma; Methylnitrosourea; Mice; Mutation; Neoplasms, Radiation-Induced; Oncogenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Thymus Neoplasms; Transformation, Genetic | 1988 |
Cocarcinogenicity of saccharin and N-alkylnitrosoureas in cultured human diploid fibroblasts.
Topics: Antigens, Neoplasm; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Ethylnitrosourea; Fibroblasts; Humans; Insulin; Interphase; Methylnitrosourea; Saccharin | 1988 |
N-methyl-N-nitrosourea-induced transformation of rat urothelial cells in vitro is not mediated by activation of ras oncogenes.
Topics: Animals; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Epithelium; Gene Expression Regulation; Genes, ras; Intermediate Filaments; Methylnitrosourea; Mice; Mice, Nude; Molecular Sequence Data; Mutation; Neoplasms, Experimental; Rabbits; Transcriptional Activation; Urinary Bladder | 1987 |
Reactions of ultimate carcinogens with cell membranes: importance of carbamoylation of phosphatidylethanolamine by the carcinogens.
Topics: Animals; Cell Membrane; Cell Transformation, Neoplastic; Chickens; Erythrocyte Membrane; Kidney; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Lipids; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Phosphatidylethanolamines; Rats | 1988 |
Neoplastic transformation of mouse mammary epithelial cells by in vitro exposure to N-methyl-N-nitrosourea.
Topics: Animals; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Epithelial Cells; Epithelium; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Precancerous Conditions | 1988 |
[Induction of brain tumors with methylnitrosourea. Comparative study of 2 strains of rats].
Topics: Animals; Brain; Brain Neoplasms; Cell Transformation, Neoplastic; Methylnitrosourea; Rats; Rats, Inbred Strains | 1987 |
Modification of N-methyl-N-nitrosourea-induced urinary bladder carcinogenesis in rats following stimulation of urothelial proliferation by a partial cystectomy.
Topics: Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Neoplastic; Epithelial Cells; Epithelium; Female; Methylnitrosourea; Rats; Rats, Inbred Strains; Time Factors; Urinary Bladder; Urinary Bladder Neoplasms | 1986 |
Isolation and characterization of chemically transformed pancreatic acinar cell lines from young and old mice.
Topics: Acetylglucosamine; Aging; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Isoenzymes; Karyotyping; L-Lactate Dehydrogenase; Lectins; Male; Methylnitrosourea; Mice; Pancreatic Neoplasms; Phenotype; Plant Lectins; Soybean Proteins; Tetradecanoylphorbol Acetate | 1987 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
Transforming growth factors induce markers of neoplasia in cultured adult rat bladder.
Topics: Animals; Cell Transformation, Neoplastic; Epidermal Growth Factor; Male; Methylnitrosourea; Mice; Microscopy, Electron, Scanning; Organ Culture Techniques; Peptides; Rats; Rats, Inbred F344; Transforming Growth Factors; Urinary Bladder | 1985 |
Studies on the mechanisms of altered exocrine acinar cell differentiation and ductal metaplasia following nitrosamine exposure using hamster pancreatic explant organ culture.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; Mesocricetus; Metaplasia; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Organ Culture Techniques; Pancreas; Pancreatic Neoplasms; Phenotype | 1985 |
N-methyl-N-nitrosourea induces dysplasia and cell surface markers of neoplasia in long-term rat bladder organ cultures.
Topics: Animals; Cell Differentiation; Cell Membrane; Cell Transformation, Neoplastic; Epithelial Cells; Epithelium; Female; Methylnitrosourea; Microscopy, Electron, Scanning; Microvilli; Nitrosourea Compounds; Organ Culture Techniques; Rats; Rats, Inbred F344; Time Factors; Urinary Bladder; Urinary Bladder Neoplasms | 1985 |
Leukemogenesis by methylnitrosourea in BDF1 mice. The origin of transplantable cells and the activity of the natural killer cells during the preleukemic period.
Topics: Animals; Cell Transformation, Neoplastic; Cytotoxicity, Immunologic; Female; Killer Cells, Natural; Leukemia; Lymph Nodes; Methylnitrosourea; Mice; Neoplasm Transplantation; Preleukemia; Spleen; Thymoma; Thymus Gland | 1985 |
On the theory of clonal selection in carcinogenic transformation.
Topics: Cell Line; Cell Transformation, Neoplastic; Clone Cells; Dose-Response Relationship, Drug; Kinetics; Methylnitrosourea; Temperature | 1974 |