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methylnitrosourea and Cancer of the Thymus

methylnitrosourea has been researched along with Cancer of the Thymus in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	30 (38.96)	18.7374
1990's	29 (37.66)	18.2507
2000's	13 (16.88)	29.6817
2010's	4 (5.19)	24.3611
2020's	1 (1.30)	2.80

Authors

Authors	Studies
Choi, YK; Kang, AR; Kang, BC; Kim, NW; Lee, HW; Lee, JH; Seo, SM; Yoo, ES	1
Clark-Knowles, KV; Coulombe, J; Daneshmand, M; Dewar-Darch, D; He, X; Jardine, KE; McBurney, MW	1
Chen, Z; Du, X; Gao, J; Guo, M; Huo, X; Li, C; Li, Z; Wang, C; Zhang, S	1
Ishchenko, IY; Kabakov, AV; Kazakov, OV; Konenkov, VI; Michurina, SV; Poveshchenko, AF; Raiter, TV; Strunkin, DN	1
Bailey, KL; Ball, DJ; Lorenzen, MJ; Morton, D; Stout, CL; Weaver, RJ; White, KA	1
Huang, RF; Wu, ZZ; Yu, YH	1
Huang, RF; Liu, QH; Qu, LJ; Wu, ZZ; Xiong, XS; Yu, YH; Zeng, L	1
Fan, SY; Wu, ZZ; Yu, YH	1
Bacchi, MM; da Silva Franchi, CA; de Camargo, JL; Padovani, CR	1
Hatakeyama, K; Kodama, Y; Kominami, R; Niwa, O; Ochiai, Y; Sato, H; Tamura, Y	1
Kodama, Y; Kominami, R; Niwa, O; Takagi, R; Tamura, Y; Wakana, S; Yoshikai, Y	1
Angel, JM; Benavides, F; Conti, CJ; Flores, M; Fuchs-Young, R; Gomez, G; Lambertz, I; Richie, ER; Venables-Griffith, A	1
Chung, YJ; Jang, JJ; Kang, HM; Langford, C; Park, SY; Shin, SH	1
D'Eustachio, P; Guerrero, I; Pellicer, A; Villasante, A	1
Dorsch-Häsler, K; Mayer, A	1
Altaner, C; Drescher, B; Ehm, I; Fey, F; Paliege, R	1
Asbery, LJ; Chandler, PM; Harris, G; Jones, MG; Lawley, PD	1
Frei, JV; Lawley, PD	1
Lawley, PD	1
Börzsönyi, M; Pintér, A	1
Chan, FP; Ens, B; Frei, JV	1
Allay, E; Dumenco, LL; Fan, CY; Gerson, SL; Liu, L; O'Connor, PJ; Zaidi, NH	1
Bayona, W; Newcomb, EW; Pisharody, S	1
Moore, J; Richie, E; Romach, E; Rummel, S	1
Harris, G; Lawley, PD	1
Allay, E; Dumenco, LL; Gerson, SL; Liu, L	1
Angel, JM; Morizot, DC; Richie, ER	2
Berns, A; Feller, A; Godfraind, C; Merz, H; Renauld, JC; van der Lugt, N; van Roon, M; Van Snick, J; Vink, A; Warnier, G	1
Mangues, R; Oliva, MR; Pellicer, A; Saez, GT	1
Allay, E; Dumenco, LL; Gerson, SL; Norton, K	1
Fukushima, S; Kurata, Y; Mizoguchi, M; Montesano, R; Naito, H; Shibata, MA; Tsuda, H; Wild, CP	1
Angel, JM; Richie, ER; Rinchik, EM	1
Newcomb, EW	1
Krucher, NA; Ludlow, JW	1
Ishikawa, T; Sakumi, K; Sekiguchi, M; Shimizu, S; Shiraishi, A; Tsuzuki, T	1
Allay, E; Gerson, SL; Koç, ON; McGuire, EA; Reese, JS; Sedransk, N	1
Ishikawa, T; Kawate, H; Nakatsuru, Y; Noda, T; Sakumi, K; Sekiguchi, M; Takahashi, S; Takano, H; Tsuzuki, T	1
Lord, BI; Lorimore, SA; McDonald, D; Papworth, D; Scott, D; Stones, VA; Wang, L; Woolford, LB; Wright, EG	1
Allay, E; Gerson, SL; Veigl, M	1
Gerson, SL; Liu, L; Qin, X	1
Gerson, SL; Liu, L; Qin, X; Zhou, H	1
Ide, F; Ishikawa, T; Itoh, R; Kawate, H; Nakabeppu, Y; Nawata, H; Noda, T; Sakumi, K; Sekiguchi, M; Tsuzuki, T	1
Clarkin, KZ; Gomez, G; Infante, AJ; Kraig, E; Richie, ER	1
Frei, JV	1
Fu, XY; Welte, T; Zhang, SS	1
Frei, JV; Joshi, VV	1
Allay, E; Gerson, SL; Reese, JS	1
Angel, JM; Richie, ER	1
Frei, JV; Venitt, S	1
Frei, JV; Lawley, PD; Swenson, DH; Warren, W	1
Koestner, A; Koestner, AW; Ruecker, FA	1
Palestro, G; Stramignoni, A	1
Maronpot, RR; Narisawa, T; Weisburger, JH; Wong, CQ	1
Cabral, JR; Rossi, L; Terracini, B; Testa, MC	1
Collier, JM; Forsyth, CA; Frank, AA; Kerkvliet, NI; Oughton, JA	1
Bayona, W; Brathwaite, O; Newcomb, EW	1
Angel, JM; Cloyd, MW; Richie, ER	1
Corominas, M; Newcomb, EW; Pellicer, A; Perucho, M	1
Pellicer, A; Sloan, SR	1
Conti, CJ; Richie, ER; Rummel, SA; Stettner, SL	1
Clark, JP; Cooper, CS; Gardner, E; Harris, G; Lawley, PD; Warren, W	1
Becker, FF	2
Cordon, C; Newcomb, EW; Pellicer, A	1
Corominas, M; Diamond, LE; Guerrerro, I; Newcomb, EW; Pellicer, A; Sloan, SR	1
Angel, JM; McEntire, B; Richie, ER	1
Becker, FF; Nairn, RS; Richie, ER	1
Ball, JK; Cooper, CS; Gardner, E; Harris, G; Lawley, PD; Warren, W	1
Newcomb, EW; Pellicer, A; Steinberg, JJ	1
Gill, TJ; Hattori, A; Kunz, HW; Pan, SF; Shinozuka, H	1
Diamond, LE; Guerrero, I; Pellicer, A	1
Richie, ER	1
Corces, V; Guerrero, I; Pellicer, A; Villasante, A	1
Grompe, M; Kreja, L; Schmidt, J; Seidel, HJ	1
Hiraki, S	2

Reviews

3 review(s) available for methylnitrosourea and Cancer of the Thymus

Article	Year
DNA as a target of alkylating carcinogens. British medical bulletin, 1980, Volume: 36, Issue:1 Topics: Alkylation; Animals; Base Composition; Carcinogens; DNA; Dose-Response Relationship, Drug; Female; Humans; Lymphoma; Male; Methylnitrosourea; Mice; Mutation; Thymus Neoplasms; Time Factors	1980
Tlag1, a novel murine tumor susceptibility gene that regulates MNU-induced thymic lymphoma development. Progress in clinical and biological research, 1996, Volume: 395 Topics: Animals; Carcinogens; Chromosome Mapping; Cocarcinogenesis; Crosses, Genetic; Disease Susceptibility; Genes; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Sequence Deletion; Species Specificity; Thymus Neoplasms	1996
Radiation and chemical activation of ras oncogenes in different mouse strains. Environmental health perspectives, 1989, Volume: 81 Topics: Animals; Genes, ras; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Mutation; Neoplasms, Radiation-Induced; Species Specificity; Thymus Neoplasms; Transformation, Genetic	1989

Other Studies

74 other study(ies) available for methylnitrosourea and Cancer of the Thymus

Article	Year
Short-term carcinogenicity study of N-methyl-N-nitrosourea in FVB-Trp53 heterozygous mice. PloS one, 2023, Volume: 18, Issue:1 Topics: Animals; Carcinogenicity Tests; Carcinogens; Humans; Lung Neoplasms; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Thymus Neoplasms	2023
Modulating SIRT1 activity variously affects thymic lymphoma development in mice. Experimental cell research, 2018, 10-01, Volume: 371, Issue:1 Topics: Adenocarcinoma of Lung; Administration, Oral; Animals; Antineoplastic Agents, Hormonal; Carcinogenesis; Gene Expression Regulation, Neoplastic; Lymphoma, T-Cell; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oncogene Proteins, Fusion; Organ Specificity; Protein-Tyrosine Kinases; Signal Transduction; Sirtuin 1; Survival Analysis; Tamoxifen; Thymus Gland; Thymus Neoplasms; Transfection	2018
Analysis of the relationship between microsatellite instability and thymic lymphoma induced by N-methyl-N-nitrosourea in C57BL/6J mice. Mutation research, 2015, Volume: 771 Topics: Alkylating Agents; Animals; Genetic Loci; Humans; Liver Neoplasms; Lymphoma; Methylnitrosourea; Mice; Microsatellite Instability; Neoplasm Metastasis; Thymus Neoplasms; Time Factors	2015
The Thymus in Experimental Mammary Carcinogenesis and Polychemotherapy. Bulletin of experimental biology and medicine, 2017, Volume: 162, Issue:4 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Carcinogens; Cell Transformation, Neoplastic; Cyclophosphamide; Epithelial Cells; Female; Fluorouracil; Injections, Intraperitoneal; Lymphocytes; Macrophages; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methotrexate; Methylnitrosourea; Rats, Wistar; Thymus Gland; Thymus Neoplasms	2017
N-Methyl-N-Nitrosourea (MNU): A positive control chemical for p53+/- mouse carcinogenicity studies. Toxicologic pathology, 2008, Volume: 36, Issue:7 Topics: Adenocarcinoma; Adenoma; Animals; Carcinogenicity Tests; Carcinogens; CD3 Complex; Duodenal Neoplasms; Female; Genes, p53; Heterozygote; Injections, Intraperitoneal; Intestine, Small; Jejunal Neoplasms; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Knockout; Neoplasms; Thymus Gland; Thymus Neoplasms	2008
[Establishment of an animal model with thymic lymphoma in mice]. Zhongguo shi yan xue ye xue za zhi, 2009, Volume: 17, Issue:5 Topics: Animals; Female; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Thymus Neoplasms; Trimethylsilyl Compounds	2009
[Pathological features and ultrastructure of N-methyl-N-nitrosourea (MNU)-induced thymic lymphomas in mice]. Zhongguo shi yan xue ye xue za zhi, 2009, Volume: 17, Issue:6 Topics: Animals; Female; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Thymus Gland; Thymus Neoplasms	2009
[Improvement of mouse model for thymic lymphoma induced by N-methyl-N-nitrosourea]. Zhongguo shi yan xue ye xue za zhi, 2010, Volume: 18, Issue:4 Topics: Animals; Female; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Thymus Neoplasms	2010
Thymic lymphomas in Wistar rats exposed to N-methyl-N-nitrosourea (MNU). Cancer science, 2003, Volume: 94, Issue:3 Topics: Animals; Body Weight; Bone Marrow; Carcinogens; Male; Methylnitrosourea; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rats; Rats, Wistar; Spleen; Thymus Neoplasms	2003
The D4Mit12 locus on mouse chromosome 4 provides susceptibility to both gamma-ray-induced and N-methyl-N-nitrosourea-induced thymic lymphomas. Cancer science, 2003, Volume: 94, Issue:8 Topics: Animals; Chromosome Mapping; DNA Primers; Gamma Rays; Genetic Markers; Lymphoma; Methylnitrosourea; Mice; Neoplasms, Radiation-Induced; Polymorphism, Single-Stranded Conformational; Thymus Neoplasms	2003
The D5Mit7 locus on mouse chromosome 5 provides resistance to gamma-ray-induced but not N-methyl-N-nitrosourea-induced thymic lymphomas. Carcinogenesis, 2004, Volume: 25, Issue:1 Topics: Animals; Chromosome Mapping; Gamma Rays; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred BALB C; Neoplasms, Radiation-Induced; Radiation Tolerance; Species Specificity; Thymus Neoplasms	2004
Differential susceptibility to chemically induced thymic lymphomas in SENCARB and SSIN inbred mice. Molecular carcinogenesis, 2006, Volume: 45, Issue:7 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Female; Flow Cytometry; Genetic Predisposition to Disease; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred SENCAR; Mice, Inbred Strains; Species Specificity; Thymus Neoplasms	2006
DNA copy number alterations and expression of relevant genes in mouse thymic lymphomas induced by gamma-irradiation and N-methyl-N-nitrosourea. Cancer genetics and cytogenetics, 2006, Apr-01, Volume: 166, Issue:1 Topics: Alkylating Agents; Animals; Chromosome Aberrations; Chromosomes; DNA, Neoplasm; Female; Gamma Rays; Gene Dosage; Gene Expression Profiling; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Thymus Neoplasms	2006
Isolation, characterization, and chromosome assignment of mouse N-ras gene from carcinogen-induced thymic lymphoma. Science (New York, N.Y.), 1984, Sep-07, Volume: 225, Issue:4666 Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromosome Mapping; Cloning, Molecular; Cricetinae; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; Genetic Linkage; Hybrid Cells; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Oncogenes; Thymus Neoplasms	1984
Endogenous MuLV infection does not contribute to onset of radiation- or carcinogen-induced murine thymoma. Nature, 1982, Jan-21, Volume: 295, Issue:5846 Topics: Alleles; Animals; Carcinogens; Crosses, Genetic; Leukemia Virus, Murine; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Thymoma; Thymus Neoplasms	1982
Characterization of the murine leukemia virus activated during N-nitroso-N-methylurea-induced leukemogenesis in mice. II. Dualtropism of the activated virus. Archiv fur Geschwulstforschung, 1982, Volume: 52, Issue:8 Topics: Animals; Leukemia Virus, Murine; Leukemia, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Thymoma; Thymus Neoplasms	1982
Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen. Immunology, 1983, Volume: 49, Issue:3 Topics: Anemia, Hemolytic, Autoimmune; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Species Specificity; Spleen; Thymoma; Thymus Neoplasms	1983
Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response. Journal of the National Cancer Institute, 1980, Volume: 64, Issue:4 Topics: Alkylating Agents; Animals; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Kinetics; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Rats; Thymoma; Thymus Neoplasms	1980
RNA oncovirus expression in N-methyl-n-nitrosourea-induced lymphomas in mice. International journal of cancer, 1981, Aug-15, Volume: 28, Issue:2 Topics: Animals; Animals, Newborn; Cocarcinogenesis; Lymphoma; Methylnitrosourea; Mice; Neoplasms, Experimental; Retroviridae; Thymus Gland; Thymus Neoplasms; Virus Activation	1981
Cytogenetics of murine thymic lymphomas induced by N-methyl-N-nitrosourea: difference in incidence of trisomy 15 in thymic lymphomas induced in neonatal and adult mice. Cancer genetics and cytogenetics, 1981, Volume: 4, Issue:4 Topics: Age Factors; Animals; Animals, Newborn; Chromosome Aberrations; Chromosome Banding; Karyotyping; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Thymus Neoplasms; Trisomy	1981
Alkyltransferase transgenic mice: probes of chemical carcinogenesis. Mutation research, 1994, Jun-01, Volume: 307, Issue:2 Topics: Actins; Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogens; DNA Repair; Female; Gene Expression Regulation, Enzymologic; Immunoenzyme Techniques; Liver Neoplasms, Experimental; Lymphoma; Male; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; Models, Genetic; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Phosphoenolpyruvate Carboxykinase (GTP); Promoter Regions, Genetic; Thymus Neoplasms	1994
N-methylnitrosourea-induced Ki-ras codon 12 mutations: early events in mouse thymic lymphomas. Molecular carcinogenesis, 1995, Volume: 13, Issue:2 Topics: Animals; Base Sequence; Codon; Female; Genes, ras; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Precancerous Conditions; Thymus Gland; Thymus Neoplasms	1995
Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas. Carcinogenesis, 1994, Volume: 15, Issue:10 Topics: Animals; Antigens, Differentiation; Cocarcinogenesis; Drug Administration Schedule; Female; Genes, ras; Gonadal Steroid Hormones; Injections, Intraperitoneal; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred AKR; Mutation; Orchiectomy; Ovariectomy; Phenotype; Sex Factors; Testosterone; Thymus Neoplasms	1994
The susceptibility of inbred mice to the production of malignant thymoma by N-methyl-N-nitrosourea. Carcinogenesis, 1994, Volume: 15, Issue:6 Topics: Age Factors; Animals; Guanine; Major Histocompatibility Complex; Methylnitrosourea; Mice; Mice, Inbred Strains; Species Specificity; Thymoma; Thymus Neoplasms	1994
Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas. Cancer research, 1994, Sep-01, Volume: 54, Issue:17 Topics: Animals; DNA; DNA Repair; Guanine; Lymphoma; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Species Specificity; Thymus Gland; Thymus Neoplasms	1994
Localization of a novel chromosome 7 locus that suppresses development of N-Methyl-N-nitrosourea-induced murine thymic lymphomas. Molecular carcinogenesis, 1993, Volume: 7, Issue:3 Topics: Animals; Base Sequence; Chromosome Mapping; Genes, Tumor Suppressor; Genetic Linkage; Male; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymorphism, Restriction Fragment Length; Thymoma; Thymus Neoplasms	1993
Thymic lymphomas in interleukin 9 transgenic mice. Oncogene, 1994, Volume: 9, Issue:5 Topics: Animals; Interleukin-9; Lymphoma, T-Cell; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasm Transplantation; Thymus Neoplasms	1994
Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status. Molecular carcinogenesis, 1994, Volume: 9, Issue:1 Topics: Animals; Base Sequence; Female; Gene Amplification; Genes, p53; Harderian Gland; Hyperplasia; Lymphoma; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred DBA; Mice, Transgenic; Molecular Sequence Data; Neoplasm Proteins; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Nuclear Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Thymus Neoplasms	1994
The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase. Science (New York, N.Y.), 1993, Jan-08, Volume: 259, Issue:5092 Topics: Animals; DNA Repair; Gene Expression; Humans; Lymphoma, T-Cell; Methylnitrosourea; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; RNA, Messenger; Thymus Neoplasms	1993
Influence of aging on multi-organ carcinogenesis in rats induced by N-methyl-N-nitrosourea. Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:2 Topics: Adenocarcinoma; Aging; Animals; Bromodeoxyuridine; Deoxyguanosine; DNA; Intestinal Neoplasms; Lymphoma; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Splenic Neoplasms; Thymus Neoplasms; Tongue Neoplasms	1993
Clonal evolution of N-methylnitrosourea-induced C57BL/6J thymic lymphomas by analysis of multiple genetic alterations. Leukemia research, 1997, Volume: 21, Issue:3 Topics: Animals; Carcinogens; Clone Cells; Female; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mutation; Thymus Neoplasms; Trisomy	1997
Clonal evolution of N-methylnitrosourea-induced C57BL/6J thymic lymphomas by analysis of multiple genetic alterations. Leukemia research, 1997, Volume: 21, Issue:3 Topics: Animals; Carcinogens; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Thymus Neoplasms; Trisomy	1997
Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice. Cancer research, 1997, Jun-15, Volume: 57, Issue:12 Topics: Animals; Carcinogens; Gene Dosage; Liver Neoplasms; Lung Neoplasms; Lymphoma; Methylnitrosourea; Methyltransferases; Mice; Mice, Knockout; O(6)-Methylguanine-DNA Methyltransferase; Survival Rate; Thymus Neoplasms	1997
Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase. Oncogene, 1997, Oct-23, Volume: 15, Issue:17 Topics: Animals; Carcinogens; Codon; DNA-Binding Proteins; Genes, ras; LIM Domain Proteins; Lymphoma; Metalloproteins; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Oncogene Proteins; Point Mutation; Thymus Neoplasms; Transcription Factors	1997
Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. Proceedings of the National Academy of Sciences of the United States of America, 1998, Apr-28, Volume: 95, Issue:9 Topics: Adaptor Proteins, Signal Transducing; Alkylating Agents; Animals; Carrier Proteins; DNA Repair; Female; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Knockout; MutL Protein Homolog 1; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Survival Analysis; Thymus Neoplasms	1998
Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239. British journal of cancer, 1998, Volume: 78, Issue:3 Topics: Animals; Bone Marrow Cells; Cell Count; Chromosome Aberrations; Colony-Forming Units Assay; Female; Leukemia, Experimental; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred CBA; Mice, Inbred DBA; Paternal Exposure; Plutonium; Spermatozoa; Spleen; Thymus Neoplasms; Time Factors	1998
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea. Oncogene, 1999, Jun-24, Volume: 18, Issue:25 Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Codon; DNA Adducts; DNA Damage; DNA Methylation; Genes, ras; Guanine; Humans; Lac Operon; Lymphoma; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Organ Specificity; Point Mutation; Spleen; Thymus Gland; Thymus Neoplasms; Transgenes	1999
Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT. Oncogene, 1999, Jul-29, Volume: 18, Issue:30 Topics: Adenosine Triphosphatases; Animals; Carcinogens; DNA Repair Enzymes; DNA-Binding Proteins; Genetic Predisposition to Disease; Humans; Hypersensitivity; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mismatch Repair Endonuclease PMS2; Models, Biological; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Proteins; Thymus Neoplasms; Time Factors	1999
Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis. Carcinogenesis, 1999, Volume: 20, Issue:9 Topics: Adenosine Triphosphatases; Animals; Carcinogens; DNA; DNA Damage; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance; Genes, ras; Genetic Complementation Test; Humans; Lymphoma; Methylation; Methylnitrosourea; Mice; Mice, Knockout; Mice, Transgenic; Mismatch Repair Endonuclease PMS2; O(6)-Methylguanine-DNA Methyltransferase; Proteins; Recombinant Fusion Proteins; Thymus Neoplasms	1999
A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice. Carcinogenesis, 2000, Volume: 21, Issue:2 Topics: Adaptor Proteins, Signal Transducing; Alkylating Agents; Alleles; Animals; Carcinogens; Carrier Proteins; Codon; Disease Progression; DNA Mutational Analysis; DNA, Neoplasm; Gene Deletion; Genes, ras; Genetic Predisposition to Disease; Genotype; Intestinal Neoplasms; Lethal Dose 50; Lymphoma; Methylnitrosourea; Mice; Mice, Knockout; MutL Protein Homolog 1; Neoplasm Proteins; Neoplasms, Experimental; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Thymus Neoplasms	2000
TCR v(beta) repertoire restriction and lack of CDR3 conservation implicate TCR-superantigen interactions in promoting the clonal evolution of murine thymic lymphomas. International immunology, 2000, Volume: 12, Issue:3 Topics: Animals; Antigens, Neoplasm; Antigens, Viral; Cell Transformation, Neoplastic; Clonal Deletion; Cocarcinogenesis; Complementarity Determining Regions; Endogenous Retroviruses; Female; Gammaretrovirus; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Genes, bcl-2; Immunoglobulin Variable Region; Lymphoma; Male; Membrane Glycoproteins; Methylnitrosourea; Mice; Mice, Inbred AKR; Neoplasm Proteins; Precancerous Conditions; Proto-Oncogene Proteins c-bcl-2; Receptors, Antigen, T-Cell, alpha-beta; Superantigens; Thymus Neoplasms	2000
Methylnitrosourea induction of thymomas in AKR mice requires one or two "hits" only. Carcinogenesis, 1980, Volume: 1, Issue:8 Topics: AKR murine leukemia virus; Animals; Carcinogens; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; Female; Methylnitrosourea; Mice; Mice, Inbred AKR; Oncogenes; Thymoma; Thymus Neoplasms	1980
Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice. Experimental and molecular pathology, 2001, Volume: 70, Issue:3 Topics: Animals; DNA-Binding Proteins; Female; Genotype; Homozygote; Incidence; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; STAT4 Transcription Factor; Thymus Neoplasms; Time Factors; Trans-Activators	2001
Gross and microscopic changes in the lymphoreticular system during genesis of malignant lymphoma induced by a single injection of methylnitrosourea in adult mice. Journal of the National Cancer Institute, 1970, Volume: 44, Issue:2 Topics: Animals; Injections; Lymph Nodes; Lymphoma; Male; Mesentery; Methylnitrosourea; Mice; Mice, Inbred Strains; Spleen; Splenic Neoplasms; Thymus Gland; Thymus Neoplasms	1970
Overexpression of human O6-alkylguanine DNA alkyltransferase (AGT) prevents MNU induced lymphomas in heterozygous p53 deficient mice. Oncogene, 2001, Aug-30, Volume: 20, Issue:38 Topics: Alkylating Agents; Alleles; Animals; Blotting, Western; Carcinogens; DNA Adducts; Exons; Flow Cytometry; Genes, p53; Genes, ras; Heterozygote; Homozygote; Humans; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Thymus Gland; Thymus Neoplasms; Time Factors	2001
Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4. Molecular carcinogenesis, 2002, Volume: 33, Issue:2 Topics: Animals; Carcinogens; Chromosome Mapping; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Thymus Neoplasms	2002
Chromosome damage in the bone marrow of mice treated with the methylating agents methyl methanesulphonate and N-methyl-N-nitrosourea in the presence or absence of caffeine, and its relationship with thymoma induction. Mutation research, 1975, Volume: 30, Issue:1 Topics: Animals; Bone Marrow; Bone Marrow Cells; Caffeine; Chromosome Aberrations; Chromosome Deletion; Chromosomes; Drug Synergism; Female; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mutagens; Nitrosourea Compounds; Specific Pathogen-Free Organisms; Thymoma; Thymus Neoplasms	1975
Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid The Biochemical journal, 1978, Sep-15, Volume: 174, Issue:3 Topics: Alkylation; Animals; Carcinogens; DNA; Ethyl Methanesulfonate; Ethylnitrosourea; Lymphoma; Methylnitrosourea; Mice; Neoplasms, Experimental; Thymus Neoplasms; Tissue Distribution	1978
Morphology and pathogenesis of tumors of the thymus and stomach in Sprague-Dawley rats following intragastric administration of methyl nitrosourea (MNU). International journal of cancer, 1977, Sep-15, Volume: 20, Issue:3 Topics: Animals; Lymphoma; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Stomach Neoplasms; Thymus Neoplasms; Time Factors	1977
Nitrosomethylurea-induced lymphomas in thymectomized mice, in relation to thymus-dependent and independent systems. Oncology, 1975, Volume: 31, Issue:2 Topics: Adenoma; Animals; Cell Transformation, Neoplastic; Female; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Rats; T-Lymphocytes; Thymectomy; Thymus Neoplasms	1975
Large bowel carcinogenesis in mice and rats by several intrarectal doses of methylnitrosourea and negative effect of nitrite plus methylurea. Cancer research, 1976, Volume: 36, Issue:2 Pt 1 Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma, Squamous Cell; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Intestinal Neoplasms; Intestine, Large; Lung Neoplasms; Lymphoma; Male; Methylnitrosourea; Mice; Nitrites; Nitrosourea Compounds; Rectal Neoplasms; Thymus Neoplasms; Urea	1976
The roles of age at treatment and dose in carcinogenesis in C3Hf/Dp mice with a single administration of N-nitroso-N-methylurea. British journal of cancer, 1976, Volume: 33, Issue:4 Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitrosourea Compounds; Stomach Neoplasms; Thymus Neoplasms	1976
Flow cytometric analysis of thymic lymphosarcoma induced by N-methyl-N-nitrosourea in C57B1/6J mice. Carcinogenesis, 1992, Volume: 13, Issue:3 Topics: Animals; Antigens, CD; Antigens, Differentiation; CD24 Antigen; CD4 Antigens; CD8 Antigens; Flow Cytometry; Lymphoma, Non-Hodgkin; Membrane Glycoproteins; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Phenotype; Thymus Neoplasms	1992
p53 mutations in C57BL/6J murine thymic lymphomas induced by gamma-irradiation and N-methylnitrosourea. Cancer research, 1992, Jul-01, Volume: 52, Issue:13 Topics: Animals; Female; Gamma Rays; Genes, p53; Genes, ras; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mutation; Thymus Neoplasms; Trisomy	1992
Influence of murine leukemia proviral integrations on development of N-methyl-N-nitrosourea-induced thymic lymphomas in AKR mice. Journal of virology, 1991, Volume: 65, Issue:11 Topics: Animals; DNA, Neoplasm; DNA, Viral; Female; Leukemia Virus, Murine; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred AKR; Thymus Neoplasms; Virus Integration	1991
Differential expression of the normal and mutated K-ras alleles in chemically induced thymic lymphomas. Cancer research, 1991, Oct-01, Volume: 51, Issue:19 Topics: Animals; Blotting, Northern; DNA; Dose-Response Relationship, Drug; Gene Expression; Genes, ras; Injections, Intraperitoneal; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Nucleic Acid Hybridization; Polymerase Chain Reaction; RNA; RNA Probes; Thymus Neoplasms	1991
Staging of T-cell receptor beta chain gene rearrangements and ras oncogene mutations in the development of murine thymic lymphomas. Cancer research, 1991, Mar-15, Volume: 51, Issue:6 Topics: Animals; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Genes, ras; Lymphoma; Methylnitrosourea; Mice; Mutation; Neoplasm Staging; Thymus Neoplasms; Time Factors	1991
N-methyl-N-nitrosourea alters thymocyte subset distribution and targets immature CD4-8+ cells for lymphoma development. Cancer research, 1991, Jan-15, Volume: 51, Issue:2 Topics: Animals; Antigens, Differentiation, T-Lymphocyte; CD4 Antigens; CD8 Antigens; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred AKR; T-Lymphocyte Subsets; Thymus Gland; Thymus Neoplasms	1991
Chemical induction of thymomas in AKR mice: interaction of chemical carcinogens and endogenous murine leukemia viruses. Comparison of N-methyl-N-nitrosourea and methyl methanesulphonate. Molecular carcinogenesis, 1990, Volume: 3, Issue:3 Topics: Animals; DNA, Neoplasm; Gene Expression Regulation; Gene Rearrangement; Genes, ras; Leukemia Virus, Murine; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred AKR; Mink Cell Focus-Inducing Viruses; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Proviruses; Thymoma; Thymus Neoplasms; Transcription, Genetic	1990
Role of the AKR gene locus AKv-1 in susceptibility to chemical induction of thymic lymphomas. Cancer research, 1990, Oct-01, Volume: 50, Issue:19 Topics: Alleles; Animals; Disease Susceptibility; Female; Genes, Viral; Leukemia Virus, Murine; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred AKR; Organ Size; Thymus Gland; Thymus Neoplasms	1990
Comparative analysis and anatomic distribution of ras p21, IL-2R, and MEL-14 in malignant and hyperplastic murine thymus. The American journal of pathology, 1990, Volume: 136, Issue:2 Topics: Animals; Cortisone; Female; Flow Cytometry; Hyperplasia; Immunohistochemistry; Lymphoma; Methylnitrosourea; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Receptors, Immunologic; Receptors, Interleukin-2; Receptors, Lymphocyte Homing; Thymus Gland; Thymus Neoplasms	1990
Failure of the viable yellow (Avy) and lethal yellow (Ay) genes to enhance chemical induction of thymic lymphomas. Carcinogenesis, 1988, Volume: 9, Issue:9 Topics: alpha-Fetoproteins; Animals; Methylnitrosourea; Mice; Mice, Mutant Strains; Thymoma; Thymus Neoplasms	1988
Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7. Journal of the National Cancer Institute, 1989, Nov-01, Volume: 81, Issue:21 Topics: Albinism; Animals; Chromosome Mapping; Genes, Recessive; Genes, Viral; Leukemia Virus, Murine; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred AKR; Thymus Neoplasms	1989
N-methyl-N-nitrosourea-induced T-lymphomas of AKR/J mice contain somatically acquired ecotropic-like murine leukemia proviruses. Virology, 1988, Volume: 164, Issue:1 Topics: Animals; DNA, Neoplasm; DNA, Viral; Leukemia Virus, Murine; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred AKR; Mink Cell Focus-Inducing Viruses; Proviruses; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocytes; Thymus Neoplasms	1988
Proviral structure and differentiation antigen phenotype of spontaneous and chemically induced AKR lymphomas. Cancer research, 1985, Volume: 45, Issue:6 Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Antigens, Ly; Antigens, Surface; DNA, Viral; Genes, Viral; Leukemia Virus, Murine; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred AKR; Phenotype; Thymus Neoplasms	1985
Induction of thymomas by N-methyl-N-nitrosourea in AKR mice: interaction between the chemical carcinogen and endogenous murine leukaemia viruses. Carcinogenesis, 1987, Volume: 8, Issue:1 Topics: Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cocarcinogenesis; DNA Restriction Enzymes; Kinetics; Leukemia Virus, Murine; Methylnitrosourea; Mice; Thymoma; Thymus Neoplasms; Transfection	1987
ras oncogenes and phenotypic staging in N-methylnitrosourea- and gamma-irradiation-induced thymic lymphomas in C57BL/6J mice. Cancer research, 1988, Oct-01, Volume: 48, Issue:19 Topics: Animals; DNA, Neoplasm; Female; Genes, ras; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasm Staging; Neoplasms, Radiation-Induced; Phenotype; T-Lymphocytes; Thymus Neoplasms	1988
Diversity of the promoting action of cyclosporine on the induction of murine lymphoid tumors. Carcinogenesis, 1988, Volume: 9, Issue:6 Topics: Animals; Carcinogens; Cyclosporins; Drug Synergism; Immunoenzyme Techniques; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Radiation-Induced; Receptors, Antigen, B-Cell; Species Specificity; Thymus Neoplasms	1988
Concomitant K- and N-ras gene point mutations in clonal murine lymphoma. Molecular and cellular biology, 1988, Volume: 8, Issue:5 Topics: Alleles; Animals; Cell Transformation, Neoplastic; DNA, Neoplasm; Lymphoma; Methylnitrosourea; Mice; Mutation; Neoplasms, Radiation-Induced; Oncogenes; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Thymus Neoplasms; Transformation, Genetic	1988
N-methyl-N-nitrosourea-induced and spontaneous AKR/J thymic lymphomas express distinct differentiation antigen phenotypes. Leukemia research, 1988, Volume: 12, Issue:3 Topics: Animals; Antigens, Differentiation; Antigens, Ly; Biomarkers, Tumor; Cell Transformation, Viral; Macromolecular Substances; Methylnitrosourea; Mice; Mice, Inbred AKR; Phenotype; Receptors, Antigen, T-Cell; Sarcoma, Experimental; Thymus Neoplasms	1988
Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:23 Topics: Alleles; Animals; Base Sequence; Brain; Chromosome Mapping; Genes, Dominant; Lymphoma; Methylnitrosourea; Mice; Mutation; Proto-Oncogenes; Thymus Neoplasms	1985
RNA virus expression during and after methylnitrosourea-induced T-cell leukemogenesis in mice. Blut, 1985, Volume: 51, Issue:6 Topics: Animals; Bone Marrow; Enzyme-Linked Immunosorbent Assay; Female; Leukemia, Experimental; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Retroviridae; Spleen; T-Lymphocytes; Thymoma; Thymus Neoplasms; Tumor Virus Infections; Viral Proteins	1985
N,N'-dimethylnitrosourea-induced tumors in mice and Syrian hamsters. Acta medica Okayama, 1974, Volume: 28, Issue:5 Topics: Animals; Cricetinae; Female; Injections, Subcutaneous; Lung Neoplasms; Lymphoma; Male; Mammary Neoplasms, Experimental; Mediastinal Neoplasms; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Retroviridae; Stomach Neoplasms; Thymus Neoplasms; Transplantation, Homologous	1974
Induction of malignant lymphomas by N,N'-dimethylnitrosourea in adult mice. Gan, 1971, Volume: 62, Issue:2 Topics: Animals; Carcinogens; Female; Lymphatic Metastasis; Lymphoma; Male; Methylation; Methylnitrosourea; Mice; Microscopy, Electron; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Thymus Neoplasms; Urea	1971