methylnitrosourea has been researched along with Cancer of Lung in 82 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 48 (58.54) | 18.7374 |
1990's | 17 (20.73) | 18.2507 |
2000's | 9 (10.98) | 29.6817 |
2010's | 7 (8.54) | 24.3611 |
2020's | 1 (1.22) | 2.80 |
Authors | Studies |
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Choi, YK; Kang, AR; Kang, BC; Kim, NW; Lee, HW; Lee, JH; Seo, SM; Yoo, ES | 1 |
Du, G; Hou, X; Li, H; Li, J; Liu, W; Liu, Y; Sun, T; Wang, Y; Zhang, Y; Zhao, B | 1 |
Bausinger, J; Duong, G; Linsenmeyer, R; Speit, G | 1 |
Adams, DJ; Balmain, A; Delrosario, R; Fredlund, E; Gurley, KE; Halliwill, KD; Jen, KY; Keane, TM; Kemp, CJ; Quigley, DA; Rashid, M; Rust, AG; To, MD; Westcott, PM | 1 |
Amin, SG; Belinsky, SA; Collins, LB; Crowell, RE; Desai, D; Gilliland, FD; Jauregui, AR; Juri, DE; Leng, S; Lin, Y; Liu, Y; Picchi, MA; Stidley, CA; Swenberg, JA; Tellez, CS; Thomas, CL; Wathelet, MG; Wu, G; Zhang, X | 1 |
Chatziioannou, A; Kolisis, F; Koryllou, A; Moulos, P; Papadodima, O; Piroti, G; Pletsa, V | 1 |
Colarusso, C; Pinto, A; Popolo, A; Sorrentino, R; Terlizzi, M | 1 |
Koryllou, A; Patrinou-Georgoula, M; Pletsa, V; Troungos, C | 1 |
Dai, H; Hua, Y; Shen, B; Xu, H; Zheng, L; Zhou, M | 1 |
Gerson, SL; Grasso, AW; Kern, J; Kung, HJ; Lee, K; Liu, L; Qin, X; Wagner, T; Willis, JE; Zhou, H | 1 |
Furukawa, F; Hirose, M; Imazawa, T; Natsume, M; Nishikawa, A; Okazaki, K; Osakabe, N; Yamagishi, M | 1 |
Estensen, RD; Wattenberg, LW; Wiedmann, TS | 1 |
Arends, MJ; Berry, RL; Brownstein, DG; Devenney, PS; Hagan, S; Harrison, DJ; Hooper, ML; Kolch, W; Luo, F; Patek, CE; Plowman, SJ; Rose, L; Sansom, OJ; Walker, M; Wallace, WA | 1 |
Gorbunova, VA; Kuz'minov, AE; Naskhletashvili, DR | 1 |
Borisov, VI; Dement'eva, NP | 1 |
Bychkov, MB; Perevodchikova, NI | 1 |
Benfield, JR; Cohen, AH; Fu, PC; Hammond, WG; Jensen, T; Pak, HY; Paladugu, RR; Shors, EC; Teplitz, RL | 1 |
Danil'ian, VM; Linchenko, IF | 1 |
Nomura, T | 1 |
Becci, PJ; Grubbs, CJ; Moon, RC; Thompson, HJ | 1 |
Anisimov, VN | 1 |
Chandrasekaran, V; Milmore, JE; Weisburger, JH | 1 |
Coombes, RC; Gusterson, BA; Williams, JC | 1 |
Adamowski, CB; Fiks, A; McCormick, DL; Moon, RC | 1 |
Faiferman, I; Ghosh, BC; Ghosh, L; Nassauer, J | 1 |
Iversen, OH; Kauffman, SL | 1 |
Müller, HA; Schäffer, R | 1 |
Sokolova, II; Trakhtenberg, AKh; Trubnikova, EN | 1 |
Kolarić, K; Roth, A | 1 |
Luckert, PH; Pollard, M; Scheu, J | 1 |
Akagi, K; Hirose, M; Hoshiya, T; Ito, N; Mizoguchi, Y; Shirai, T | 1 |
Doi, ST; Katsuki, M; Kimura, M | 1 |
Coccia, JB; Galbraith, AR; Wattenberg, LW | 1 |
Hagiwara, K; Ichikawa, T; Murakami, A; Yano, T; Yuasa, M | 1 |
Ashbaugh, P; Bhattacharyya, SN; Coutinho, R; Kaufman, B; Manna, B | 1 |
Ishikawa, T; Sakumi, K; Sekiguchi, M; Shimizu, S; Shiraishi, A; Tsuzuki, T | 1 |
Asamoto, M; Kim, DJ; Kim, JM; Murakoshi, M; Nir, Z; Nishino, H; Ota, T; Sekine, K; Takasuka, N; Tsuda, H | 1 |
Hirose, M; Shibutani, M; Shoda, T; Takada, K; Takahashi, M; Tamura, T; Toyoda, K; Uneyama, C | 1 |
Anderson, MW; Kelloff, GJ; Lantry, LE; Liu, Q; Lubet, RA; Wang, Y; Wiseman, RW; You, M; Zhang, Z | 1 |
Kim, DJ; Nishino, H; Takasuka, N; Tsuda, H | 1 |
Hirano, K; Itoh, F; Kominami, G; Nara, H; Ohno, K; Tasaki, T; Torii, M; Yabuuchi, K | 1 |
Enck, RE | 1 |
Bychkov, MB; Korman, NP; Perevodchikova, NI | 1 |
Perevodchikova, NI | 1 |
Assekritova, IV; Batinov, IN; Bychkov, MB; Perevodchikova, NI; Vaarik, KhM | 1 |
Benfield, JR; Cohen, AH; Matsumura, K; Shors, EC | 1 |
Reuber, MD | 1 |
Broggini, M; Colombo, T; Donelli, MG; Garattini, S | 1 |
Lokich, JJ; Skarin, AT | 1 |
Schabel, FM | 1 |
Pozharisskiĭ, KM | 1 |
Benfield, JR; Cohen, AH; Jensen, T; Matsumura, K; Okita, M; Shors, E | 1 |
Bychkov, MB; Perevodchikova, NI; Starichkov, MS | 1 |
Dement'eva, ND; Korman, DB | 1 |
Kmoch, N; Mohr, U; Reznik, G | 1 |
Palestro, G; Stramignoni, A | 1 |
Carter, SK; Slavik, M; Wasserman, TH | 1 |
Maronpot, RR; Narisawa, T; Weisburger, JH; Wong, CQ | 1 |
Cabral, JR; Rossi, L; Terracini, B; Testa, MC | 1 |
Detrisac, CJ; Kelloff, GJ; Moon, RC; Rao, KV | 2 |
Cho, KJ; Chung, HT; Jan, JJ; Lee, YS; Seo, JS | 1 |
Benfield, JR; Hammond, WG | 1 |
Castonguay, A; Goldblatt, PJ; Gunning, WT; Stoner, GD | 1 |
Bae, JH; Cho, KJ; Jang, JJ; Lee, YS | 1 |
Iwasaki, S; Masui, T; Shirai, T; Tamano, S; Yamamoto, A | 1 |
Moroz, IA; Pelevina, II; Sergeeva, NS; Skotinkova, OI; Sviridova, IK | 1 |
Bopp, BA; Kesterson, JW; Sonders, RC | 1 |
Korman, DB; Mikaélian, SG | 1 |
Anderson, MW; Candrian, U; Maronpot, RR; Stoner, GD; You, M | 1 |
Kerler, R; Rabes, HM; Sarafoff, M; Suchy, BK | 1 |
Bychkov, MB; Gertner, K; Mikhina, ZP; Motorina, LI; Trofimova, NB | 1 |
Bychkov, MB | 1 |
Lijinsky, W; Reuber, MD | 1 |
Gor'kov, VA; Kim, OA; Korman, DB | 1 |
Luckert, PH; Pollard, M | 1 |
Iversen, OH; Kirkhus, B; Kristensen, A | 1 |
Katyal, SL; Ohshima, M; Singh, G; Ward, JM | 1 |
Parmiani, G; Pezzoni, G; Pratesi, G | 1 |
Okulov, VB; Petrov, AS; Pliss, GB; Zabezhinski, MA | 1 |
Hiraki, S | 1 |
Harris, CC | 1 |
9 review(s) available for methylnitrosourea and Cancer of Lung
Article | Year |
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[Combination chemotherapy with newly-developed cytostatics for disseminated small cell lung cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Small Cell; Cisplatin; Clinical Trials, Phase II as Topic; Disease-Free Survival; Docetaxel; Drug Administration Schedule; Female; Glycosides; Humans; Irinotecan; Lung Neoplasms; Male; Methylnitrosourea; Middle Aged; Taxoids; Treatment Outcome | 2007 |
[Polychemotherapy and radiotherapy for small cell cancer of the lung].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Humans; Lomustine; Lung Neoplasms; Methotrexate; Methylnitrosourea; Prednisone; Procarbazine; Vincristine | 1983 |
Carcinogenicity of saccharin.
Topics: Animals; Carcinogens; Diet; Female; Lung Neoplasms; Male; Methylnitrosourea; Mice; Parasitic Diseases; Rats; Saccharin; Sex Factors; Species Specificity; Tosyl Compounds; United States; United States Food and Drug Administration; Urinary Bladder Calculi; Urinary Bladder Neoplasms; Urogenital Neoplasms | 1978 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Combination; Leukemia L1210; Lomustine; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Semustine | 1976 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyrenes; Brain Neoplasms; Carcinogens; Cricetinae; Dimethylhydrazines; Dogs; Esophageal Neoplasms; Ethionine; Ethylnitrosourea; Female; Hematopoietic System; Intestinal Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Nitrosoguanidines; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Precancerous Conditions; Rats; Skin Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms | 1975 |
Clinical comparison of the nitrosoureas.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carmustine; Chemical Phenomena; Chemistry; Colonic Neoplasms; Drug Therapy, Combination; Hodgkin Disease; Humans; Lomustine; Lung Neoplasms; Lymphoma; Melanoma; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Rectal Neoplasms | 1975 |
Hamster lung cancer model of carcinogenesis and chemoprevention.
Topics: Administration, Topical; Animals; Anticarcinogenic Agents; Cricetinae; Diethylnitrosamine; Lung Neoplasms; Mesocricetus; Methylnitrosourea; Retinoids | 1992 |
Toxicological aspects of cyclamate and cyclohexylamine.
Topics: Abnormalities, Drug-Induced; Absorption; Adrenal Glands; Animals; Bacteria; Blood; Blood Glucose; Chick Embryo; Chromosome Aberrations; Cocarcinogenesis; Cricetinae; Cyclamates; Cyclohexylamines; Digestive System; Female; Germ Cells; Heart; Humans; In Vitro Techniques; Intestines; Kidney; Lethal Dose 50; Liver; Liver Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Macaca mulatta; Male; Methylnitrosourea; Mice; Mutagenicity Tests; Mutagens; Mutation; Neoplasms, Experimental; Pancreas; Pregnancy; Rabbits; Rats; Rats, Inbred Strains; Reproduction; Sympathomimetics; Testis; Thyroid Gland; Tissue Distribution; Urinary Bladder Neoplasms | 1986 |
Cause and prevention of lung cancer.
Topics: Animals; Asbestos; Benzopyrenes; Cricetinae; Disease Models, Animal; Humans; Lung Neoplasms; Methylnitrosourea; Neoplasms; Neoplasms, Experimental; Orthomyxoviridae; Smoking; Vitamin A | 1974 |
1 trial(s) available for methylnitrosourea and Cancer of Lung
Article | Year |
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Nitrosourea combination chemotherapy: 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (methyl-CCNU) and cyclophosphamide.
Topics: Adult; Aged; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Lomustine; Lung Neoplasms; Male; Methylnitrosourea; Middle Aged; Neoplasms; Nitrosourea Compounds; Stomach Neoplasms | 1975 |
72 other study(ies) available for methylnitrosourea and Cancer of Lung
Article | Year |
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Short-term carcinogenicity study of N-methyl-N-nitrosourea in FVB-Trp53 heterozygous mice.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Humans; Lung Neoplasms; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Thymus Neoplasms | 2023 |
Hypothermia activates adipose tissue to promote malignant lung cancer progression.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Alkylating Agents; Animals; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Proliferation; Cold-Shock Response; Disease Progression; DNA Damage; Epithelial-Mesenchymal Transition; Female; Humans; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Tumor Burden; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2013 |
Investigations on potential co-mutagenic effects of formaldehyde.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylating Agents; Chromosome Aberrations; Comet Assay; Disinfectants; Drug Combinations; Drug Synergism; Formaldehyde; Gamma Rays; Humans; Lung Neoplasms; Methyl Methanesulfonate; Methylnitrosourea; Micronucleus Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2014 |
The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma, Non-Small-Cell Lung; Cell Transformation, Neoplastic; Disease Progression; DNA Copy Number Variations; Female; Genes, ras; Genomic Instability; Germ-Line Mutation; Humans; Lung Neoplasms; Male; Methylnitrosourea; Mice; Models, Genetic; Mutation; Oncogene Protein p21(ras); Point Mutation; Proto-Oncogene Proteins p21(ras); Urethane | 2015 |
Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.
Topics: Base Sequence; Chromosomes, Human, Pair 15; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epithelial Cells; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Guanine; Humans; Longitudinal Studies; Lung Neoplasms; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Polymorphism, Single Nucleotide; Smoking; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2015 |
Modulation of Pathways Underlying Distinct Cell Death Mechanisms in Two Human Lung Cancer Cell Lines in Response to SN1 Methylating Agents Treatment.
Topics: A549 Cells; Alkylating Agents; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Line, Tumor; Dacarbazine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Humans; Lung Neoplasms; Methylnitrosourea; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Temozolomide | 2016 |
IL-1α and IL-1β-producing macrophages populate lung tumor lesions in mice.
Topics: Adenosine Triphosphate; Animals; Bronchoalveolar Lavage Fluid; Calpain; Carcinogenesis; Caspase 1; Caspase Inhibitors; Caspases; Caspases, Initiator; Cells, Cultured; Clodronic Acid; Dipeptides; Female; Glyburide; Inflammasomes; Interleukin-1alpha; Interleukin-1beta; Lipopolysaccharides; Lung Neoplasms; Macrophages, Alveolar; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Experimental; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Specific Pathogen-Free Organisms; Toll-Like Receptor 4 | 2016 |
Cell death induced by N-methyl-N-nitrosourea, a model S(N)1 methylating agent, in two lung cancer cell lines of human origin.
Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Nucleus; Cell Survival; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Indoles; Lung Neoplasms; Methylnitrosourea; Microscopy, Confocal; Neoplasm Proteins; Poly(ADP-ribose) Polymerases; Propidium; Staining and Labeling; Tumor Stem Cell Assay | 2009 |
Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line; Chromosome Aberrations; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Repair; DNA Replication; Flap Endonucleases; Genetic Predisposition to Disease; Hydrogen Peroxide; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Mutant Strains; Microscopy, Fluorescence; Point Mutation | 2011 |
Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Genes, erbB; Genes, erbB-2; Genes, ras; Humans; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Transgenic; Mutation; Transgenes | 2002 |
Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Anthocyanins; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Cacao; Carcinoma; Catechin; Diethylnitrosamine; Drug Administration Schedule; Drug Screening Assays, Antitumor; Flavonoids; Gastrointestinal Neoplasms; Injections, Intraperitoneal; Injections, Subcutaneous; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Organ Specificity; Phenols; Phytotherapy; Pituitary Neoplasms; Plant Extracts; Polymers; Proanthocyanidins; Rats; Rats, Inbred F344; Thyroid Neoplasms; Urogenital Neoplasms | 2003 |
Chemoprevention of cancer of the upper respiratory tract of the Syrian golden hamster by aerosol administration of difluoromethylornithine and 5-fluorouracil.
Topics: Administration, Inhalation; Aerosols; Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Eflornithine; Fluorouracil; Laryngeal Neoplasms; Lung Neoplasms; Male; Mesocricetus; Methylnitrosourea; Pharyngeal Neoplasms | 2004 |
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.
Topics: Animals; Disease Progression; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Knockout; Mutagenesis; Mutant Proteins; Protein Isoforms; ras Proteins; Signal Transduction; Tumor Burden | 2008 |
[Use of nitrosomethylurea in the chemotherapy of small cell cancer of the lung].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Humans; Lung Neoplasms; Methylnitrosourea; Nitrosourea Compounds | 1984 |
Modern problems of clinical chemotherapy of malignant tumours.
Topics: Antineoplastic Agents; Carcinoma, Small Cell; Carubicin; Dacarbazine; Dactinomycin; Drug Therapy, Combination; Female; Humans; Lomustine; Lung Neoplasms; Male; Melanoma; Methylnitrosourea; Neoplasms; Sarcoma; Skin Neoplasms; Soft Tissue Neoplasms; Vincristine | 1980 |
A clinically relevant canine lung cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Delayed-Action Preparations; Disease Models, Animal; Dogs; Lung Neoplasms; Methods; Methylcholanthrene; Methylnitrosourea; Neoplasms, Experimental; Radioisotopes; Tetradecanoylphorbol Acetate | 1981 |
Timing of chemically induced neoplasia in mice revealed by the antineoplastic action of caffeine.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; DNA Repair; Ethylnitrosourea; Female; Hydroxamic Acids; Lung Neoplasms; Maternal-Fetal Exchange; Methylnitrosourea; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Nitroquinolines; Pregnancy; Time Factors; Urethane | 1980 |
Histogenesis and dose dependence of N-methyl-N-nitrosourea-induced carcinoma in a localized area of the hamster trachea.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Male; Mesocricetus; Methylnitrosourea; Mucous Membrane; Neoplasms, Experimental; Nitrosourea Compounds; Time Factors; Tracheal Neoplasms | 1980 |
Carcinogenesis and aging. I. Modifying effects of aging on N-methyl-N-nitrosourea-induced carcinogenesis in female rats.
Topics: Aging; Animals; Female; Kidney Neoplasms; Leukemia; Lung Neoplasms; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms; Nitrosourea Compounds; Rats; Thymoma; Uterine Cervical Neoplasms; Vaginal Neoplasms | 1981 |
Effects of hypothyroidism on development of nitrosomethylurea-induced tumors of the mammary gland, thyroid gland, and other tissues.
Topics: Animals; Female; Hypothyroidism; Kidney Neoplasms; Lung Neoplasms; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Inbred F344; Thyroid Neoplasms; Thyroxine; Triiodothyronine | 1982 |
Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour.
Topics: Adenocarcinoma; Animals; Female; Lung Neoplasms; Lymphatic Metastasis; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Metastasis; Rats; Rats, Inbred F344; Receptors, Estrogen | 1982 |
Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea.
Topics: Adenocarcinoma; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Kidney Neoplasms; Lung Neoplasms; Mammary Neoplasms, Experimental; Methylnitrosourea; Nitrosourea Compounds; Rats; Sarcoma, Experimental | 1981 |
Pathology of metastasizing tumors in nitrosomethyl urea-induced rat mammary carcinoma.
Topics: Adenocarcinoma; Animals; Female; Liver Neoplasms; Lung Neoplasms; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Transplantation; Nitrosourea Compounds; Rats; Rats, Inbred BUF; Splenic Neoplasms | 1981 |
Circadian variation in the susceptibility of mouse epidermis to chemical carcinogens.
Topics: Adenoma; Animals; Circadian Rhythm; Drug Interactions; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Hairless; Papilloma; Propiolactone; Skin Neoplasms; Time Factors | 1981 |
On the development of metastasizing tumors of the rat thyroid gland after combined administration of nitrosomethylurea and methylthiouracil.
Topics: Animals; Female; Lung; Lung Neoplasms; Methylnitrosourea; Methylthiouracil; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Thyroid Gland; Thyroid Neoplasms | 1980 |
[Hematopoiesis during combined treatment of lung cancer patients with cyclophosphan and nitrosomethylurea or CCNU].
Topics: Adult; Aged; Anemia, Aplastic; Cyclophosphamide; Female; Humans; Lomustine; Lung Neoplasms; Male; Methylnitrosourea; Middle Aged; Nitrosourea Compounds | 1980 |
Treatment of metastatic brain tumors with the combination of 1-methyl-1-nitrosourea (MNU) and cyclophosphamide.
Topics: Adult; Aged; Brain Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Dysgerminoma; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Male; Melanoma; Methylnitrosourea; Middle Aged; Nitrosourea Compounds; Parotid Neoplasms; Testicular Neoplasms | 1980 |
Phenobarbital promotes the development of adenocarcinomas in the accessory sex glands of MNU-inoculated L-W rats.
Topics: Abdominal Neoplasms; Adenocarcinoma; Adenoma; Aging; Animals; Carcinogens; Drug Implants; Genital Neoplasms, Male; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Peritoneal Neoplasms; Phenobarbital; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Seminal Vesicles; Testosterone | 1995 |
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Topics: 1,2-Dimethylhydrazine; Animals; Benzaldehydes; Butylhydroxybutylnitrosamine; Diethylnitrosamine; Dimethylhydrazines; Drug Screening Assays, Antitumor; Ellagic Acid; Gastrointestinal Neoplasms; Kidney Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Multiple Primary; Nitrosamines; Quercetin; Random Allocation; Rats; Rats, Inbred F344 | 1995 |
Site-specific mutation of the human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Squamous Cell; Codon; Genes, ras; Hemangiosarcoma; Humans; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Transgenic; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Point Mutation; Polymerase Chain Reaction; Promoter Regions, Genetic; Splenic Neoplasms; Stomach Neoplasms | 1994 |
Inhibition of carcinogen-induced pulmonary and mammary carcinogenesis by chalcone administered subsequent to carcinogen exposure.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Chalcone; Female; Lung Neoplasms; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred A; Rats; Rats, Sprague-Dawley; Stomach Neoplasms | 1994 |
The detection of chemically initiated cells having the mutation of K-ras gene at an early stage of lung carcinogenesis in mice.
Topics: Animals; Blotting, Southern; DNA; Genes, ras; Lung Neoplasms; Male; Methylnitrosourea; Mice; Mutation; Polymerase Chain Reaction; Precancerous Conditions; Sensitivity and Specificity | 1997 |
Differentiation of respiratory epithelium: the effects of retinoic acid and carcinogens on the expression of mucociliary vs. squamous phenotype.
Topics: Animals; Benzo(a)pyrene; Carcinogens; Carcinoma, Squamous Cell; Cell Differentiation; Culture Media; Culture Techniques; Epithelium; Gene Expression; Lung Neoplasms; Metaplasia; Methylnitrosourea; Mucins; Phenotype; Rats; RNA, Messenger; Trachea; Tretinoin; Vitamin A Deficiency | 1997 |
Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.
Topics: Animals; Carcinogens; Gene Dosage; Liver Neoplasms; Lung Neoplasms; Lymphoma; Methylnitrosourea; Methyltransferases; Mice; Mice, Knockout; O(6)-Methylguanine-DNA Methyltransferase; Survival Rate; Thymus Neoplasms | 1997 |
Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH.
Topics: 1,2-Dimethylhydrazine; Animals; Body Weight; Carotenoids; Chemoprevention; Colonic Neoplasms; Diethylnitrosamine; Female; Liver Neoplasms; Liver Neoplasms, Experimental; Lung Neoplasms; Lycopene; Male; Methylnitrosourea; Mice; Organ Size | 1997 |
Tumor-promoting activities of hydroquinone and 1,1-dimethylhydrazine after initiation of newborn mice with 1-methyl-1-nitrosourea.
Topics: Adenoma; Animals; Animals, Newborn; Body Weight; Carcinogens; Carcinoma; Dimethylhydrazines; Female; Hydroquinones; Liver; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Mice; Mice, Inbred ICR; Mutagens; Organ Size | 1999 |
A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.
Topics: Alleles; Animals; Anticarcinogenic Agents; Dexamethasone; Doxorubicin; Genes, p53; Germ-Line Mutation; Humans; Inositol; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Transgenic; Nitrosamines; Paclitaxel; Proto-Oncogene Mas; Tea | 2000 |
Chemoprevention of lung cancer by lycopene.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Carotenoids; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Lung Neoplasms; Lycopene; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Sex Characteristics | 2000 |
Twenty-six-week carcinogenicity study of sulfamethoxazole in CB6F1-Tg-rasH2 mice.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Female; Genes, ras; Harderian Gland; Humans; Hyperplasia; Lung Neoplasms; Male; Methylnitrosourea; Mice; Mice, Transgenic; Neoplasms, Experimental; Splenic Neoplasms; Sulfamethoxazole; Thyroid Gland | 2001 |
Mallory-Weiss lesion following cancer chemotherapy.
Topics: Drug Therapy, Combination; Fluorouracil; Humans; Lung Neoplasms; Male; Mallory-Weiss Syndrome; Methylnitrosourea; Middle Aged; Neoplasm Metastasis; Nitrosourea Compounds; Semustine; Vomiting | 1977 |
[Treatment of patients with lung cancer with a combination of nitrosomethylurea and cyclophosphane].
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methylnitrosourea; Middle Aged; Nitrosourea Compounds | 1975 |
Chemotherapy for lung cancer.
Topics: Adenocarcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Therapy, Combination; Humans; Lung Neoplasms; Mechlorethamine; Methylnitrosourea; Nitrosourea Compounds | 1976 |
[Comparative study of the effectiveness of N-nitrosomethylurea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea combined with cyclophosphane in inoperable lung cancer].
Topics: Adenocarcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Therapy, Combination; Humans; Lomustine; Lung Neoplasms; Methylnitrosourea; Nitrosourea Compounds | 1978 |
Cytologic correlates of chemical carcinogens in respiratory tracts of dogs.
Topics: Animals; Benzopyrenes; Cell Nucleolus; Cell Nucleus; Cytodiagnosis; Cytoplasm; Dogs; Epithelium; Lung Neoplasms; Metaplasia; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Precancerous Conditions; Time Factors | 1978 |
Differential distribution of antitumor agents in primary and secondary tumors.
Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma 256, Walker; Cyclophosphamide; Daunorubicin; Doxorubicin; Female; Hydroxyurea; Lung Neoplasms; Lymphatic Metastasis; Male; Mercaptopurine; Methotrexate; Methylnitrosourea; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Rats; Sarcoma, Experimental | 1977 |
Techniques for localized injections and topical applications of carcinogens at specific endobronchial sites in dogs.
Topics: Administration, Topical; Animals; Benzopyrenes; Bronchoscopes; Carcinogens; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Dogs; Injections; Lung Neoplasms; Methylnitrosourea; Neoplasms, Experimental | 1977 |
[Combined chemo-radiotherapy of small-cell cancer of the lung].
Topics: Adult; Carcinoma; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Methotrexate; Methylnitrosourea; Middle Aged; Radiotherapy Dosage | 1977 |
[Nitrosomethylurea in polychemotherapy of malignant tumors].
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Drug Therapy, Combination; Humans; Lung Neoplasms; Methylnitrosourea; Neoplasms; Nitrosourea Compounds | 1977 |
Carcinogenic effects of different nitroso-compounds in chinese hamsters: N-dibutylnitrosamine and N-nitrosomethylurea.
Topics: Animals; Cricetinae; Female; Lethal Dose 50; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Nitrosourea Compounds | 1976 |
Nitrosomethylurea-induced lymphomas in thymectomized mice, in relation to thymus-dependent and independent systems.
Topics: Adenoma; Animals; Cell Transformation, Neoplastic; Female; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Rats; T-Lymphocytes; Thymectomy; Thymus Neoplasms | 1975 |
Large bowel carcinogenesis in mice and rats by several intrarectal doses of methylnitrosourea and negative effect of nitrite plus methylurea.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma, Squamous Cell; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Intestinal Neoplasms; Intestine, Large; Lung Neoplasms; Lymphoma; Male; Methylnitrosourea; Mice; Nitrites; Nitrosourea Compounds; Rectal Neoplasms; Thymus Neoplasms; Urea | 1976 |
The roles of age at treatment and dose in carcinogenesis in C3Hf/Dp mice with a single administration of N-nitroso-N-methylurea.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitrosourea Compounds; Stomach Neoplasms; Thymus Neoplasms | 1976 |
Animal models for chemoprevention of respiratory cancer.
Topics: Animals; Biotransformation; Carcinoma, Squamous Cell; Cricetinae; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Lung Neoplasms; Mesocricetus; Methylnitrosourea; Retinoids | 1992 |
Lung adenoma development and NK activity in mice treated with multiple carcinogens.
Topics: Adenoma; Animals; Diethylnitrosamine; Female; Killer Cells, Natural; Lung Neoplasms; Methylnitrosourea; Mice; Phenobarbital; Random Allocation; Urethane | 1992 |
Bronchial and pulmonary carcinogenesis at focal sites in dogs and hamsters.
Topics: Animals; Benzo(a)pyrene; Bronchial Neoplasms; Bronchoscopy; Carcinogens; Cricetinae; Disease Models, Animal; Dogs; Drug Implants; Injections; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mucous Membrane | 1992 |
Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenoma; Aflatoxins; Animals; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Dimethylhydrazines; Lung Neoplasms; Methylcholanthrene; Methylnitrosourea; Mice; Mice, Inbred A; Microscopy, Electron; Nitrosamines | 1991 |
Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat.
Topics: Animals; Capsaicin; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1991 |
Induction of invasive carcinomas of the seminal vesicles and coagulating glands of F344 rats by administration of N-methylnitrosourea or N-nitrosobis(2-oxopropyl)amine and followed by testosterone propionate with or without high-fat diet.
Topics: Animals; Body Weight; Bulbourethral Glands; Colonic Neoplasms; Dietary Fats; Drug Synergism; Genital Neoplasms, Male; Kidney Neoplasms; Lung Neoplasms; Male; Methylnitrosourea; Nitrosamines; Organ Size; Prostate; Prostatic Neoplasms; Radioimmunoassay; Rats; Rats, Inbred F344; Seminal Vesicles; Testosterone; Urethral Neoplasms; Urinary Bladder Neoplasms | 1991 |
[Assessment of individual sensitivity to chemotherapy of human pulmonary tumors transplanted to subrenal capsule of CBA mice].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Cyclophosphamide; Doxorubicin; Fluorouracil; Humans; Lung Neoplasms; Male; Methotrexate; Methylnitrosourea; Mice; Mice, Inbred CBA; Prospidium; Subrenal Capsule Assay; Vincristine | 1990 |
[Survival of patients with disseminated small-cell lung cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Combined Modality Therapy; Humans; Lung Neoplasms; Methylnitrosourea; Radiotherapy; Regression Analysis | 1989 |
Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.
Topics: Animals; Benzo(a)pyrene; Cell Transformation, Neoplastic; Codon; DNA, Neoplasm; Exons; Gene Amplification; Gene Expression Regulation; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Inbred A; Mutation; Nucleic Acid Hybridization; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Proto-Oncogenes; Transfection | 1989 |
Amplification, rearrangements, and enhanced expression of c-myc in chemically induced rat liver tumors in vivo and in vitro.
Topics: Animals; Blotting, Northern; Blotting, Southern; Gene Amplification; Gene Expression Regulation, Neoplastic; Gene Rearrangement; In Vitro Techniques; Liver Neoplasms, Experimental; Lung Neoplasms; Methylnitrosourea; Phenobarbital; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Restriction Mapping; RNA, Neoplasm; Transcription, Genetic | 1989 |
[Chemoradiation treatment of the superior vena cava compression syndrome in small-cell lung cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Methylnitrosourea; Middle Aged; Radiotherapy Dosage; Remission Induction; Superior Vena Cava Syndrome; Time Factors | 1988 |
[Chemotherapy and combined chemo- and radiotherapy of small cell lung cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Combined Modality Therapy; Cyclophosphamide; Dacarbazine; Doxorubicin; Humans; Lomustine; Lung Neoplasms; Methotrexate; Methylnitrosourea; Procarbazine; Prospidium; Vincristine | 1985 |
Neoplasms of the skin and other organs observed in Swiss mice treated with nitrosoalkylureas.
Topics: Administration, Topical; Alkylation; Animals; Female; Lung Neoplasms; Methylnitrosourea; Mice; Neoplasms, Experimental; Skin Neoplasms | 1988 |
[Pharmacokinetics of nitrosomethylurea in oncologic patients].
Topics: Adult; Aged; Female; Humans; Lung Neoplasms; Lymphoma; Male; Melanoma; Methylnitrosourea; Middle Aged; Neoplasms | 1988 |
Autochthonous prostate adenocarcinomas in Lobund-Wistar rats: a model system.
Topics: Adenocarcinoma; Animals; Disease Models, Animal; Lung Neoplasms; Male; Methylnitrosourea; Prostatic Neoplasms; Rats; Testosterone | 1987 |
Carcinogenic doses of methylnitrosourea induce dose response related delay in transit through S and G2 phases in mouse epidermis: a cell kinetic study.
Topics: Adenoma; Animals; Carcinoma; DNA Replication; Flow Cytometry; Interphase; Kinetics; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Hairless; Skin; Skin Neoplasms; Thymidine | 1987 |
Immunocytochemical and morphological evidence for the origin of N-nitrosomethylurea-induced and naturally occurring primary lung tumors in F344/NCr rats.
Topics: Animals; Antigens; Apoproteins; Histocytochemistry; Immunoenzyme Techniques; Lung Neoplasms; Male; Methylnitrosourea; Rats; Rats, Inbred F344 | 1985 |
NMU-1, a new transplantable mouse lung tumor: biological and chemosensitivity properties in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cell Line; Lung Neoplasms; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C | 1985 |
Skin tumours induced by local and systemic action of N-nitroso-compounds in rats.
Topics: Administration, Topical; Animals; Carcinoma, Basal Cell; Diazonium Compounds; Female; Guanidines; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Lung Neoplasms; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Nitroso Compounds; Rats; Sarcoma, Experimental; Skin Neoplasms | 1985 |
N,N'-dimethylnitrosourea-induced tumors in mice and Syrian hamsters.
Topics: Animals; Cricetinae; Female; Injections, Subcutaneous; Lung Neoplasms; Lymphoma; Male; Mammary Neoplasms, Experimental; Mediastinal Neoplasms; Methylnitrosourea; Mice; Mice, Inbred C3H; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosourea Compounds; Retroviridae; Stomach Neoplasms; Thymus Neoplasms; Transplantation, Homologous | 1974 |