Compounds > methylnitrosourea
Page last updated: 2024-08-21

methylnitrosourea and Animal Mammary Carcinoma

methylnitrosourea has been researched along with Animal Mammary Carcinoma in 67 studies

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (5.97)18.2507
2000's35 (52.24)29.6817
2010's25 (37.31)24.3611
2020's3 (4.48)2.80

Authors

AuthorsStudies
Álvarez, L; Bergoc, R; Gutiérrez, A; Martín, G; Núñez, M; Randi, A; Sambuco, L; Zotta, E1
Andrei, S; Cătoi, AF; Gal, AF; Rugină, D; Stan, L; Tăbăran, F1
Alonso-Costa, LG; Barbisan, LF; Bidinotto, LT; de Aquino, AM; de Freitas, T; Flaws, JA; Kass, L; Moreira, CM; Scarano, WR; Zapaterini, JR1
Faustino-Rocha, AI; Ferreira, R; Gama, A; Ginja, M; Neuparth, MJ; Oliveira, PA1
Faustino-Rocha, AI; Ferreira, R; Gama, A; Ginja, M; Oliveira, PA; Pires, MJ; Saunders, JH; Vanderperren, K1
Kabakov, AV; Kazakov, OV; Konenkov, VI; Lykov, AP; Morozov, DV; Poveshchenko, AF; Raiter, TV; Strunkin, DN1
Atkins, KA; Blair, IA; Bottalico, L; Mesaros, C; Santen, RJ; Wang, J; Yue, W1
Anderson, SM; Edwards, DP; Giles, ED; Jindal, S; MacLean, PS; Schedin, P; Schedin, T; Thor, AD; Wellberg, EA1
Barbisan, LF; Bidinotto, LT; Grassi, TF; Lopes, GAD; Rodrigues, MAM; Zapaterini, JR1
Bode, A; Gill, SC; Grubbs, CJ; Iwata, KK; Juliana, MM; Lubet, RA; Nicastro, HL; Steele, VE; Szabo, E; Tucker, C1
Colaço, B; Colaço, J; da Costa, RG; Faustino-Rocha, A; Ferreira, R; Ginja, M; Oliveira, PA; Pinho-Oliveira, J; Pires, MJ; Soares-Maia, R; Teixeira-Guedes, C1
Garbow, JR; He, J; Higashikubo, R; Jones, LA; Lubet, RA; Mach, RH; Rowland, D; Shoghi, KI; Su, Y; Tu, Z; Wheeler, KT; Xu, J; Yan, Y; You, M1
Bai, X; Chen, Z; Dai, Y; Gao, Q; Gao, T; Jia, C; Lai, P; Lin, J; Ren, Z; Song, Q; Wan, Z; Wang, Y; Zhang, Y; Zhao, A; Zhao, Z; Zheng, H; Zhou, X1
Blaize, N; Breslin, E; Camarillo, IG; Clah, L; Donkin, SS; Gavin, TP; Johnson, D; Larrick, B; Newcomer, S; Patel, N; Teegarden, D; Zheng, W; Zhou, X1
Baldridge, MG; Marks, GT; Vermey, ML1
Cho, K; Choi, WS; Crane, CL; Mabasa, L; Park, CS; Singh, RK1
Elmore, SA; Emoto, Y; Kinoshita, Y; Shikata, N; Tsubura, A; Yoshizawa, K; Yuki, M; Yuri, T1
Cohick, WS; Globerman, SP; Saboya, M; Stires, H1
Alvarez de Cienfuegos, G; Carrera, MP; De Pablo, MA; Martinez-Martos, JM; Puertollano, E; Puertollano, MA; Ramirez-Expósito, MJ1
Brick, MA; Jiang, W; McGinley, JN; Thompson, HJ; Thompson, MD; Wolfe, P; Zhu, Z1
Canada, A; Collins, K; Duong, H; Esparza, D; Moreno, E; Rajkumar, L1
Grubbs, CJ; Isayeva, T; Johnson, MD; Kern, FG; Mittal, AR; Ponnazhagan, S; Qu, Z; Ramanathan, HN; Thottassery, JV; Westbrook, L1
Maffini, MV; Murray, TJ; Sonnenschein, C; Soto, AM; Ucci, AA1
Ahlers, I; Ahlersová, E; Bojková, B; Garajová, M; Kajo, K; Kassayová, M; Kisková, T; Kubatka, P; Orendás, P; Péc, M1
Adie, SG; Boppart, SA; John, R; Liang, X1
del Pilar Carrera, M; García, MJ; Martínez-Martos, JM; Mayas, MD; Ramírez-Expósito, MJ1
Christov, K; Lantvit, D; Wiehle, R; Yamada, T1
Brown, RJ; Gabrielson, E; Huso, DL; Jacobs, LK; Jeter, S; Khouri, NF; Kominsky, SL; Lange, JR; Mori, T; Powers, P; Rudek, MA; Stearns, V; Sukumar, S; Tarpinian, K; Tsangaris, TN; Yoshida, T; Zhang, Z1
Chang, WC; Chuang, JY; Hung, CY; Hung, JJ; Su, TP; Wang, SA; Yang, HC; Yang, WB1
Hongxia, X; Hui, C; Jundong, Z; Lijia, Y; Long, Y; Mantian, M; Qianyong, Z; Yong, Z; Yujie, F1
Bojkova, B; Garajova, M; Kajo, K; Kassayova, M; Kiskova, T; Korpova, M; Kubatka, P; Miklosova, M; Orendas, P; Pec, M1
Bahadir, GM; Berna, T; Berrak, Y; Can, E; Handan, K; Ipek, E; Umit, UM1
Balasubramanian, MP; Jagadeesan, J; Nandakumar, N; Rengarajan, T1
Lu, SJ; Quan, C; Wang, HL1
Chan, FL; Chen, ZY; Cheung, SY; Choi, HL; Huang, Y; James, AE1
Adlercreutz, H; Berger, MR; Elger, W; Lippert, TH; Mueck, AO; Seeger, H1
Chan, FL; Chen, S; Cheng, HK; Cheung, SY; Choi, HL; Huang, Y; Yuen, MT1
Hada, T; Inoue, Y; Kiuchi, K; Matsumura, M; Moriguchi, K; Takada, H; Tsubura, A; Yoshizawa, K; Yuri, T1
Binderup, L; Bramm, E; Colston, KW; Hamberg, KJ; Pirianov, G1
Guzman, RC; Nandi, S; Rajkumar, L; Talamantes, F; Thordarson, G; Yang, J1
Singh, M; Thompson, HJ1
Inoue, A; Jing, L; Leanderson, T; Li, V; Mikheev, AM; Mikheeva, SA; Zarbl, H1
Jiang, W; McGinley, J; Thompson, HJ; Wolfe, P; Zhu, Z1
Chan, MM; Iglehart, JD; Lu, X; Merchant, FM; Miron, PL1
Kamiyama, Y; Okugawa, H; Sakaida, N; Tanaka, K; Tanano, A; Uemura, Y; Yamamoto, D1
Fong, LY; Grubbs, CJ; Guler, G; Han, SY; Huebner, K; Iliopoulos, D; Lubet, RA1
Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW; Roomi, NW1
Ariazi, JL; Gould, MN; Haag, JD1
Bergoc, R; Carbone, V; Cocca, C; Croci, M; Gutiérrez, A; Kleiman de Pisarev, DL; Nuñez, M; Randi, AS1
Gulati, A; Rai, A; Rajeshkumar, NV1
Cho, YM; Hasumura, M; Hirose, M; Imai, T1
Anegon, I; Asghar, K; Ashgar, K; Boczkowski, J; Brion, R; Chauveau, C; Doebis, C; Hill, M; Kotsch, K; Mashreghi, MF; Mazal, D; Moffett, J; Osinaga, E; Pereira, V; Remy, S; Seifert, M; Tesson, L; Ubillos, L; Zagani, R1
Kijkuokool, P; Malaivijitnond, S; Parhar, IS1
Bosland, MC; Gordon, T; Horton, L; Lasano, S; Nadas, A; Ng, SP; Steinetz, BG; Zelikoff, JT1
Bradbury, J1
Bellinaso, Mde L; de Vargas Barbosa, NB; Guecheva, TN; Nogueira, CW; Rocha, JB1
Gao, B; Jiang, W; McGinley, JN; Price, JM; Thompson, HJ; Zhu, Z1
Borges, A; Kothari, A; Kothari, L1
Gordon, GB; Grubbs, CJ; Kelloff, GJ; Lei, XD; Lubet, RA; Moon, RD; Prough, RA; Steele, VE; Thomas, CF; Wang, Y; You, M1
Bergoc, R; Cocca, C; Cricco, G; Davio, C; Engel, N; Martin, G; Rivera, E1
Roberfroid, M; Taper, HS1
Nakagawa, H; Tsubura, A; Tsuta, K; Yang, J1
Huang, RY; Ip, MM1
Adcock, I; Ali, S; Coombes, RC; Ito, K; Mirsaidi, N; Pace, PE; Vigushin, DM1
Ahn, B; Choi, M; Jang, DD; Kang, JS; Kim, DJ; Kim, KS; Nam, KT1
Brtko, J; Líska, J; Macejová, D1
Brtko, J; Dvorcakova, M; Líska, J; Macejová, D; Mostböck, S; Scheiblhofer, S; Szabová, E; Thalhamer, J; Weiss, R; Zórad, S1

Reviews

2 review(s) available for methylnitrosourea and Animal Mammary Carcinoma

ArticleYear
Rat models of premalignant breast disease.
    Journal of mammary gland biology and neoplasia, 2000, Volume: 5, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; Disease Models, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Precancerous Conditions; Rats

2000
Influence of inulin and oligofructose on breast cancer and tumor growth.
    The Journal of nutrition, 1999, Volume: 129, Issue:7 Suppl

    Topics: Adenocarcinoma; Animals; Carcinogens; Dietary Carbohydrates; Female; Humans; Inulin; Mammary Neoplasms, Animal; Methylnitrosourea; Mice; Neoplasm Transplantation; Oligosaccharides; Pectins; Rats; Rats, Sprague-Dawley

1999

Trials

1 trial(s) available for methylnitrosourea and Animal Mammary Carcinoma

ArticleYear
Preclinical and clinical evaluation of intraductally administered agents in early breast cancer.
    Science translational medicine, 2011, Oct-26, Volume: 3, Issue:106

    Topics: Adult; Animals; Antineoplastic Agents; Breast Neoplasms; Carboplatin; Doxorubicin; Drug Administration Routes; Female; Fluorouracil; Humans; Mammary Glands, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Paclitaxel; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Young Adult

2011

Other Studies

64 other study(ies) available for methylnitrosourea and Animal Mammary Carcinoma

ArticleYear
Expression of estrogen receptor α variants and c-Fos in rat mammary gland and tumors.
    The Journal of steroid biochemistry and molecular biology, 2020, Volume: 199

    Topics: Animals; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cytoplasm; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Mammary Glands, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Protein Isoforms; Rats; Signal Transduction; Transcription Factor AP-1

2020
Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Animals; Antioxidants; Biomarkers, Tumor; Chemoprevention; Diet; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Propolis; Rats, Sprague-Dawley

2020
Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2021, Volume: 156

    Topics: Animal Feed; Animals; Carcinogenesis; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Gene Expression Regulation; Ki-67 Antigen; Mammary Neoplasms, Animal; Methylnitrosourea; Phthalic Acids; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, Progesterone

2021
Mast Cells in Mammary Carcinogenesis: Host or Tumor Supporters?
    Anticancer research, 2017, Volume: 37, Issue:3

    Topics: Animals; Cell Proliferation; Cell Transformation, Neoplastic; Female; Immunohistochemistry; Ketotifen; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mast Cells; Methylnitrosourea; Rats; Rats, Sprague-Dawley

2017
Modulation of mammary tumor vascularization by mast cells: Ultrasonographic and histopathological approaches.
    Life sciences, 2017, May-01, Volume: 176

    Topics: Animals; Female; Ketotifen; Mammary Neoplasms, Animal; Mast Cells; Methylnitrosourea; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Ultrasonography

2017
Phenotypical Characteristics of Chemically Induced Mammary Tumor.
    Bulletin of experimental biology and medicine, 2017, Volume: 163, Issue:4

    Topics: Animals; Breast Neoplasms; Cell Proliferation; ErbB Receptors; Female; Immunohistochemistry; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Wistar; Receptors, Progesterone

2017
Effect of a tissue selective estrogen complex on breast cancer: Role of unique properties of conjugated equine estrogen.
    International journal of cancer, 2018, 09-01, Volume: 143, Issue:5

    Topics: Animals; Apoptosis; Carcinogens; Cell Proliferation; Drug Therapy, Combination; Estrogen Replacement Therapy; Estrogens; Estrogens, Conjugated (USP); Female; Indoles; Mammary Neoplasms, Animal; Methylnitrosourea; Progestins; Rats; Rats, Inbred ACI; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators

2018
Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer.
    Breast cancer research : BCR, 2018, 06-14, Volume: 20, Issue:1

    Topics: Animals; Aromatase; Breast; Breast Neoplasms; Disease Progression; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; Metformin; Methylnitrosourea; Ovariectomy; Postmenopause; Rats; Stromal Cells; Tumor Microenvironment

2018
Maternal western-style diet enhances the effects of chemically-induced mammary tumors in female rat offspring through transcriptome changes.
    Nutrition research (New York, N.Y.), 2019, Volume: 61

    Topics: Animals; Diet, High-Fat; Diet, Western; Female; Gene Expression Profiling; Genes, Neoplasm; Lactation; Mammary Neoplasms, Animal; Maternal Nutritional Physiological Phenomena; Methylnitrosourea; Mothers; Neoplasm Grading; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; RNA, Messenger; Transcriptome

2019
Effect of intermittent dosing regimens of erlotinib on methylnitrosourea-induced mammary carcinogenesis.
    Cancer prevention research (Philadelphia, Pa.), 2013, Volume: 6, Issue:5

    Topics: Alkylating Agents; Animals; Blotting, Western; Dose-Response Relationship, Drug; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Survival Rate; Tissue Distribution

2013
Estimation of rat mammary tumor volume using caliper and ultrasonography measurements.
    Lab animal, 2013, Volume: 42, Issue:6

    Topics: Animals; Female; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Physical Examination; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tumor Burden; Ultrasonography

2013
Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; Benzamides; Bexarotene; Blotting, Western; Cell Proliferation; Female; Flow Cytometry; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Ligands; Mammary Neoplasms, Animal; Methylnitrosourea; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Receptors, sigma; Tetrahydronaphthalenes; Triazoles; Tumor Cells, Cultured

2013
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
    Oncogene, 2014, Sep-11, Volume: 33, Issue:37

    Topics: Animals; Breast Neoplasms; Carcinogens; Cell Line, Tumor; Cell Proliferation; Disease Progression; Fatty Acids, Omega-3; Female; Humans; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Methylnitrosourea; Mice; Mice, Nude; Mice, SCID; Multiprotein Complexes; Neoplasm Transplantation; Neovascularization, Pathologic; Rats; Signal Transduction; TOR Serine-Threonine Kinases

2014
Maternal exercise during pregnancy reduces risk of mammary tumorigenesis in rat offspring.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2014, Volume: 23, Issue:6

    Topics: Adenocarcinoma; Animals; Female; Incidence; Mammary Neoplasms, Animal; Methylnitrosourea; Physical Conditioning, Animal; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Risk Factors

2014
Effect of Thyroid Function on MNU-Induced Mammary Carcinogenesis.
    Zoological science, 2015, Volume: 32, Issue:3

    Topics: Animals; Carcinogenesis; Female; Hyperthyroidism; Hypothyroidism; Mammary Neoplasms, Animal; Methylnitrosourea; Random Allocation; Rats; Rats, Sprague-Dawley; Sexual Maturation; Thyroid Gland; Thyroxine

2015
Suppression of Mammary Carcinogenesis Through Early Exposure to Dietary Lipotropes Occurs Primarily In Utero.
    Nutrition and cancer, 2015, Volume: 67, Issue:8

    Topics: Animals; Animals, Newborn; Choline; Chromatin Assembly and Disassembly; Diet; Female; Folic Acid; Histone Deacetylases; Lactation; Mammary Neoplasms, Animal; Maternal-Fetal Exchange; Methionine; Methylnitrosourea; Pregnancy; Rats; Rats, Sprague-Dawley; Vitamin B 12

2015
Characterization of mammary adenocarcinomas in male rats after N-methyl-N-nitrosourea exposure--Potential for human male breast cancer model.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2016, Volume: 68, Issue:5

    Topics: Adenocarcinoma; Animals; Breast Neoplasms, Male; Carcinogens; Disease Models, Animal; Female; Humans; Male; Mammary Glands, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Rats

2016
Peroral Estradiol Is Sufficient to Induce Carcinogen-Induced Mammary Tumorigenesis in Ovariectomized Rats without Progesterone.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Animals; Body Weight; Carcinogenesis; Carcinogens; Cell Proliferation; Estradiol; Female; Immunohistochemistry; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Organ Size; Ovariectomy; Progesterone; Rats, Sprague-Dawley; Time Factors; Uterus

2016
Analysis of caspase activities in rat mammary tumours induced by N-methyl-nitrosourea.
    Oncology reports, 2008, Volume: 20, Issue:3

    Topics: Alkylating Agents; Animals; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 8; Caspase 9; Cytochromes c; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Mitochondria; Rats; Rats, Wistar; Tumor Cells, Cultured

2008
Mechanisms associated with dose-dependent inhibition of rat mammary carcinogenesis by dry bean (Phaseolus vulgaris, L.).
    The Journal of nutrition, 2008, Volume: 138, Issue:11

    Topics: Animal Feed; Animals; Apoptosis; Cell Proliferation; Diet; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Phaseolus; Rats; Rats, Sprague-Dawley

2008
Decreasing hormonal promotion is key to breast cancer prevention.
    Endocrine, 2009, Volume: 35, Issue:2

    Topics: Animals; Carcinogens; Estradiol; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Progesterone; Rats; Rats, Inbred Lew; Time Factors

2009
High Cks1 expression in transgenic and carcinogen-initiated mammary tumors is not always accompanied by reduction in p27Kip1.
    International journal of oncology, 2009, Volume: 34, Issue:5

    Topics: Animals; Antineoplastic Agents, Hormonal; Carcinogens; Carcinoma; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase Inhibitor p27; Drug Resistance, Neoplasm; Estradiol; Estrogens; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; Methylnitrosourea; Mice; Mice, Transgenic; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Tumor Cells, Cultured

2009
Histological analysis of low dose NMU effects in the rat mammary gland.
    BMC cancer, 2009, Aug-03, Volume: 9

    Topics: Animals; Body Weight; Disease Models, Animal; Female; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Wistar; Species Specificity; Time Factors

2009
Pioglitazone in chemically induced mammary carcinogenesis in rats.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2010, Volume: 19, Issue:5

    Topics: Animals; Anticarcinogenic Agents; Carcinogens; Dose-Response Relationship, Drug; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Pioglitazone; Random Allocation; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Treatment Outcome

2010
Dynamic spectral-domain optical coherence elastography for tissue characterization.
    Optics express, 2010, Jun-21, Volume: 18, Issue:13

    Topics: Animals; Biomarkers, Tumor; Elasticity Imaging Techniques; Equipment Design; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Models, Theoretical; Phantoms, Imaging; Rats; Rats, Inbred WF; Scattering, Radiation; Silicones; Tomography, Optical Coherence

2010
Mammary renin-angiotensin system-regulating aminopeptidase activities are modified in rats with breast cancer.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2010, Volume: 31, Issue:6

    Topics: Aminopeptidases; Angiotensin III; Animals; CD13 Antigens; Disease Models, Animal; Female; Glutamyl Aminopeptidase; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Wistar; Renin-Angiotensin System

2010
CDB-4124, a progesterone receptor modulator, inhibits mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis.
    Cancer prevention research (Philadelphia, Pa.), 2011, Volume: 4, Issue:3

    Topics: Animals; Apoptosis; Carcinogens; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Female; Humans; Mammary Neoplasms, Animal; Methylnitrosourea; Models, Biological; Norpregnadienes; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Progesterone

2011
Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells.
    Oncogene, 2012, Nov-22, Volume: 31, Issue:47

    Topics: Actins; Adenocarcinoma; Amino Acid Motifs; Animals; CDC2 Protein Kinase; Chromatin Assembly and Disassembly; Cyclin B1; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Interphase; Mammary Neoplasms, Animal; Methylnitrosourea; Mitosis; Myosins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Phosphatase 2; Protein Processing, Post-Translational; Rats; Sp1 Transcription Factor; Threonine

2012
MicroRNA-34a and microRNA-21 play roles in the chemopreventive effects of 3,6-dihydroxyflavone on 1-methyl-1-nitrosourea-induced breast carcinogenesis.
    Breast cancer research : BCR, 2012, May-22, Volume: 14, Issue:3

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cytochromes c; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Animal; Methylnitrosourea; Mice; Mice, Inbred BALB C; MicroRNAs; Rats; Rats, Sprague-Dawley; Transplantation, Heterologous

2012
Rosiglitazone shows partial oncostatic effect in rat mammary carcinogenesis.
    Neoplasma, 2013, Volume: 60, Issue:1

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Female; Glycemic Index; Hypoglycemic Agents; Insulin; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones

2013
Role of melatonin and luzindole in rat mammary cancer.
    Journal of investigative surgery : the official journal of the Academy of Surgical Research, 2012, Volume: 25, Issue:6

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Disease Models, Animal; DNA Fragmentation; Estradiol; Female; Heme Oxygenase-1; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Melatonin; Methylnitrosourea; Oxidative Stress; Progesterone; Prolactin; Rats; Rats, Sprague-Dawley; Tryptamines

2012
Diosgenin, a steroidal saponin, exhibits anticancer activity by attenuating lipid peroxidation via enhancing antioxidant defense system during NMU-induced breast carcinoma.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2012, Volume: 31, Issue:2

    Topics: Animals; Antioxidants; Diosgenin; Disease Models, Animal; Down-Regulation; Female; Lipid Peroxidation; Liver; Mammary Neoplasms, Animal; Methylnitrosourea; Phytotherapy; Plant Preparations; Rats; Rats, Sprague-Dawley; Saponins; Treatment Outcome; Trigonella

2012
Resistance to mammary carcinogenesis in Copenhagen rats: potential roles of vascular endothelial growth factor and mast cells.
    Cancer letters, 2002, Dec-05, Volume: 186, Issue:2

    Topics: Animals; Carcinogens; Cells, Cultured; Endothelial Growth Factors; Female; Genes, ras; Immunity, Innate; Intercellular Signaling Peptides and Proteins; Lymph Nodes; Lymphokines; Mammary Neoplasms, Animal; Mast Cells; Methylnitrosourea; Mutation; Phenotype; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
Spontaneous mammary tumors in aging Noble rats.
    International journal of oncology, 2003, Volume: 22, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Age of Onset; Animals; Carcinoma; Diethylstilbestrol; Drug Implants; Estradiol; Female; Fibroadenoma; Genetic Predisposition to Disease; Incidence; Male; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Metastasis; Neoplasm Transplantation; Ovariectomy; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Rodent Diseases; Species Specificity; Testosterone

2003
Effect of 2-methoxyestradiol on the growth of methyl-nitroso-urea (MNU)-induced rat mammary carcinoma.
    The Journal of steroid biochemistry and molecular biology, 2003, Volume: 84, Issue:1

    Topics: 2-Methoxyestradiol; Animals; Carcinogens; Estradiol; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Time Factors

2003
An expression study of hormone receptors in spontaneously developed, carcinogen-induced and hormone-induced mammary tumors in female Noble rats.
    International journal of oncology, 2003, Volume: 22, Issue:6

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinogens; DNA Primers; Female; Hormones; Immunohistochemistry; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Polymerase Chain Reaction; Rats; Rats, Inbred Strains; Receptors, Estrogen; Receptors, Progesterone; Receptors, Prolactin

2003
Dietary docosahexaenoic acid protects against N-methyl-N-nitrosourea-induced retinal degeneration in rats.
    Experimental eye research, 2003, Volume: 77, Issue:2

    Topics: Alkylating Agents; Animals; Apoptosis; Cell Survival; Docosahexaenoic Acids; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Photoreceptor Cells, Vertebrate; Rats; Rats, Sprague-Dawley; Retinal Degeneration

2003
Effects of Seocalcitol (EB1089) on nitrosomethyl urea-induced rat mammary tumors.
    Breast cancer research and treatment, 2003, Volume: 80, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Calcitriol; Dose-Response Relationship, Drug; Female; Hypercalcemia; Mammary Neoplasms, Animal; Methylnitrosourea; Neoplasms, Experimental; Rats; Rats, Wistar

2003
Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments.
    Breast cancer research : BCR, 2004, Volume: 6, Issue:1

    Topics: 2-Methoxyestradiol; Alkylating Agents; Animals; Antineoplastic Combined Chemotherapy Protocols; Estradiol; Estriol; Estrogens; Ethinyl Estradiol; Female; Mammary Neoplasms, Animal; Megestrol Acetate; Methylnitrosourea; Norethindrone; Progesterone; Progestins; Rats; Rats, Inbred Lew; Tamoxifen; Time Factors; Treatment Outcome

2004
Frequent activation of CArG binding factor-A expression and binding in N-methyl-N-nitrosourea-induced rat mammary carcinomas.
    Breast cancer research and treatment, 2004, Volume: 88, Issue:1

    Topics: Alkylating Agents; Animals; Cell Cycle Proteins; Cell Transformation, Neoplastic; DNA Mutational Analysis; DNA-Binding Proteins; Female; Gene Expression Profiling; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Inbred F344; Repressor Proteins; Ribonucleoproteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription Factors

2004
Effects of dietary energy repletion and IGF-1 infusion on the inhibition of mammary carcinogenesis by dietary energy restriction.
    Molecular carcinogenesis, 2005, Volume: 42, Issue:3

    Topics: Animals; Blood Glucose; Caloric Restriction; Carcinogens; Cell Transformation, Neoplastic; Corticosterone; Energy Intake; Female; Glucose; Growth Hormone; Humans; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Sprague-Dawley

2005
Gene expression profiling of NMU-induced rat mammary tumors: cross species comparison with human breast cancer.
    Carcinogenesis, 2005, Volume: 26, Issue:8

    Topics: Animals; Breast; Breast Neoplasms; Carcinogens; Cluster Analysis; Female; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Inbred WF; Species Specificity

2005
Effect of perductal paclitaxel exposure on the development of MNU-induced mammary carcinoma in female S-D rats.
    Breast cancer research and treatment, 2005, Volume: 91, Issue:1

    Topics: Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Female; Infusions, Parenteral; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Paclitaxel; Rats; Rats, Sprague-Dawley

2005
Hypermethylation patterns in the Fhit regulatory region are tissue specific.
    Molecular carcinogenesis, 2005, Volume: 43, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Acid Anhydride Hydrolases; Animals; Base Sequence; Carcinogens; DNA Methylation; DNA Primers; Female; Gene Expression Regulation; Genes, Regulator; Genes, Tumor Suppressor; Introns; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Proteins; Organ Specificity; Polymerase Chain Reaction; Rats

2005
Modulation of N-methyl-N-nitrosourea induced mammary tumors in Sprague-Dawley rats by combination of lysine, proline, arginine, ascorbic acid and green tea extract.
    Breast cancer research : BCR, 2005, Volume: 7, Issue:3

    Topics: Alkylating Agents; Animal Feed; Animals; Antioxidants; Arginine; Ascorbic Acid; Chemoprevention; Female; Injections, Intraperitoneal; Lysine; Mammary Neoplasms, Animal; Methylnitrosourea; Neoplasms, Experimental; Proline; Rats; Rats, Sprague-Dawley; Tea

2005
Methylguanine methyltransferase activity deficiency in immature rat mammary epithelial cells parallels increased carcinogenic susceptibility.
    Molecular carcinogenesis, 2005, Volume: 44, Issue:3

    Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cells, Cultured; Comet Assay; Disease Susceptibility; Epithelial Cells; Female; Mammary Neoplasms, Animal; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344

2005
Hexachlorobenzene is a tumor co-carcinogen and induces alterations in insulin-growth factors signaling pathway in the rat mammary gland.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 89, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Drug Therapy, Combination; Female; Hexachlorobenzene; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Mammary Glands, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Phosphoproteins; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Receptor, Insulin; Signal Transduction

2006
Endothelin B receptor agonist, IRL 1620, enhances the anti-tumor efficacy of paclitaxel in breast tumor rats.
    Breast cancer research and treatment, 2005, Volume: 94, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Disease Progression; Endothelin B Receptor Antagonists; Endothelins; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Paclitaxel; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Tissue Distribution

2005
Enhancement by acrylamide of N-methyl-N-nitrosourea-induced rat mammary tumor development-possible application for a model to detect co-modifiers of carcinogenesis.
    Cancer letters, 2005, Dec-08, Volume: 230, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Acrylamide; Administration, Oral; Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Disease Models, Animal; Drug Interactions; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Nitrosamines; Rats; Rats, Sprague-Dawley; Thyroid Neoplasms

2005
Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:14

    Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Heme; Heme Oxygenase-1; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Lentivirus; Mammary Neoplasms, Animal; Methylnitrosourea; Oxygen; Protein Processing, Post-Translational; Rats; RNA, Small Interfering; Signal Transduction

2005
Genistein enhances N-nitrosomethylurea-induced rat mammary tumorigenesis.
    Cancer letters, 2006, Oct-08, Volume: 242, Issue:1

    Topics: Animals; Antineoplastic Agents; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Estradiol; Estrous Cycle; Female; Genistein; Mammary Neoplasms, Animal; Methylnitrosourea; Organ Size; Phytoestrogens; Rats; Rats, Sprague-Dawley

2006
The parity-related protection against breast cancer is compromised by cigarette smoke during rat pregnancy: observations on tumorigenesis and immunological defenses of the neonate.
    Carcinogenesis, 2006, Volume: 27, Issue:6

    Topics: Animals; Carcinogens; Female; Killer Cells, Natural; Lymphocytes; Male; Mammary Neoplasms, Animal; Methylnitrosourea; Pregnancy; Pregnancy, Animal; Prolactin; Rats; Rats, Sprague-Dawley; Sex Factors; Smoking

2006
Open access to breast tumours.
    The Lancet. Oncology, 2006, Volume: 7, Issue:3

    Topics: Alkylating Agents; Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Drug Delivery Systems; Humans; Mammary Neoplasms, Animal; Methylnitrosourea; Mice; Mice, Transgenic; Rats

2006
Diphenyl diselenide supplementation delays the development of N-nitroso-N-methylurea-induced mammary tumors.
    Archives of toxicology, 2008, Volume: 82, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Ascorbic Acid; Benzene Derivatives; Biomarkers; Body Weight; Carcinogens; Comet Assay; Diet; Female; Lipid Peroxidation; Liver; Mammary Neoplasms, Animal; Methylnitrosourea; Neoplasm Proteins; Organ Size; Organoselenium Compounds; Rats; Rats, Wistar; Superoxide Dismutase

2008
Effects of dietary energy restriction on gene regulation in mammary epithelial cells.
    Cancer research, 2007, Dec-15, Volume: 67, Issue:24

    Topics: Animals; Breast; Carcinogens; Diet, Reducing; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Sprague-Dawley

2007
Chemoprevention by melatonin and combined melatonin-tamoxifen therapy of second generation nitroso-methylurea-induced mammary tumours in rats.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 1995, Volume: 4, Issue:6

    Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Chemoprevention; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Synergism; Estrogen Antagonists; Female; Mammary Neoplasms, Animal; Melatonin; Methylnitrosourea; Neoplasms, Second Primary; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Tamoxifen

1995
Modulation of methylnitrosourea-induced breast cancer in Sprague Dawley rats by dehydroepiandrosterone: dose-dependent inhibition, effects of limited exposure, effects on peroxisomal enzymes, and lack of effects on levels of Ha-Ras mutations.
    Cancer research, 1998, Mar-01, Volume: 58, Issue:5

    Topics: Animals; Cell Division; Coenzyme A Ligases; Dehydroepiandrosterone; Diet; Dose-Response Relationship, Drug; Female; Genes, ras; Mammary Neoplasms, Animal; Methylnitrosourea; Microbodies; Mutation; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley

1998
Epidermal growth factor in NMU-induced mammary tumors in rats.
    Breast cancer research and treatment, 1998, Volume: 48, Issue:2

    Topics: Animals; Carcinogens; Cyclic AMP; Epidermal Growth Factor; ErbB Receptors; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Ovariectomy; Phosphatidylinositols; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Progesterone; Transforming Growth Factor alpha

1998
Influence of perinatal genistein exposure on the development of MNU-induced mammary carcinoma in female Sprague-Dawley rats.
    Cancer letters, 2000, Feb-28, Volume: 149, Issue:1-2

    Topics: Alkylating Agents; Animals; Female; Genistein; Growth Inhibitors; Mammary Neoplasms, Animal; Methylnitrosourea; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley

2000
Differential expression of integrin mRNAs and proteins during normal rat mammary gland development and in carcinogenesis.
    Cell and tissue research, 2001, Volume: 303, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Alkylating Agents; Animals; Antigens, CD; Carcinogens; Cell Adhesion; Extracellular Matrix Proteins; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Integrin alpha5; Integrin alpha6; Integrin beta1; Integrin beta4; Mammary Glands, Animal; Mammary Neoplasms, Animal; Methylnitrosourea; Oligopeptides; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger

2001
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:4

    Topics: Animals; Antineoplastic Agents; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Wistar; Tumor Cells, Cultured

2001
Post-initiation treatment of Indole-3-carbinol did not suppress N-methyl-N-nitrosourea induced mammary carcinogenesis in rats.
    Cancer letters, 2001, Aug-28, Volume: 169, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Female; Indoles; Mammary Neoplasms, Animal; Methylnitrosourea; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors

2001
Mammary gland carcinoma-related increase of type I iodothyronine 5'-deiodinase activity in Sprague-Dawley rats.
    General physiology and biophysics, 2001, Volume: 20, Issue:3

    Topics: Animals; Carcinogens; Carcinoma; Female; Iodide Peroxidase; Mammary Neoplasms, Animal; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Time Factors

2001
Reduction of 1-methyl-1-nitrosourea-induced mammary gland carcinoma by in vivo application of immunostimulatory CpG motifs in Sprague-Dawley rats.
    General physiology and biophysics, 2001, Volume: 20, Issue:4

    Topics: Alkylating Agents; Amino Acid Motifs; Animals; Carcinogens; CpG Islands; Female; Mammary Neoplasms, Animal; Methylnitrosourea; Models, Statistical; Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Tretinoin

2001