Compounds > methylnitrosourea
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methylnitrosourea and Abnormalities, Autosome

methylnitrosourea has been researched along with Abnormalities, Autosome in 76 studies

Research

Studies (76)

TimeframeStudies, this research(%)All Research%
pre-199033 (43.42)18.7374
1990's27 (35.53)18.2507
2000's14 (18.42)29.6817
2010's2 (2.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bausinger, J; Duong, G; Linsenmeyer, R; Speit, G1
Akay, A; Cuppen, E; Feitsma, H1
Kramarenko, II; Loginova, MIu; Tronov, VA1
Dai, H; Hua, Y; Shen, B; Xu, H; Zheng, L; Zhou, M1
Gus'kov, EP; Mashkina, EV1
Gus'kov, EP; Mashkina, EV; Usatov, AV1
Dúhová, V; Farkassová, A; Kamasová, S; Kogan, G; Miadoková, E; Rauko, P; Svidová, S; Vlcek, D; Vlcková, V1
Chung, YJ; Jang, JJ; Kang, HM; Langford, C; Park, SY; Shin, SH1
Doak, SH; Jenkins, GJ; Johnson, GE; Parry, EM; Parry, JM; Quick, E1
Hering, B; Juchimiuk, J; Maluszynska, J1
Shall, S1
Natarajan, AT; Simons, JW; van Zeeland, AA; Vogel, EW1
Kukushkina, GV; Minenkova, EA; Peretolchina, NM; Sof'ina, ZP; Verovskiĭ, VN1
Kaina, B4
Pomerantseva, MD; Ramaĭia, LK; Vilkina, GA1
Mendel, J; Schwarz, H; Thust, R; Warzok, R1
Anders, A; Anders, F; Chatterjee, K; Kollinger, G; Schmidt, CR1
Chan, FP; Ens, B; Frei, JV1
Andersson, HC; Gill, BS; Grover, IS; Kanaya, N; Murin, A; Osiecka, R; Sandhu, SS1
Capucci, MS; Hoffmann, ME; Natarajan, AT1
Bean, CL; Bradt, CI; Galloway, SM; Greenwood, SK; Hill, RB1
Alekperov, UK; Gashimova, UF; Mamedova, AO; Mirza-Zade, GK1
Axelson, H; Babonits, M; Imreh, S; Klein, G; Panda, CK; Silva, S; Szeles, A; Wang, Y; Wiener, F1
Garrett, LR; Klingelhutz, AJ; McDougall, JK; Smith, PP1
Armstrong, MJ; Galloway, SM1
Hukku, B; Jin, S; Jung, M; Kuettel, MR; Rhim, JS; Thraves, PJ; Webber, MM1
Nielsen, MH; Rank, J1
Beskova, TB; Malashenko, AM; Vasil'eva, SV1
Baranczewski, P; Nehls, P; Rajewsky, MF; Rieger, R; Schubert, I1
Baranczewski, P; Nehls, P; Pich, U; Rajewsky, MF; Rieger, R; Schubert, I1
Kaelbling, M; Klinger, HP; Wang, Y; Zhang, Y1
Anisimov, VN; Mikheev, VS; Musatov, SA; Rosenfeld, SV; Togo, EF1
Lord, BI; Lorimore, SA; McDonald, D; Papworth, D; Scott, D; Stones, VA; Wang, L; Woolford, LB; Wright, EG1
Asakura, S; Daimon, H; Sagami, F; Sawada, S1
Lord, BI; Lorimore, SA; McDonald, D; Scott, D; Stones, VA; Wang, L; Woolford, LB; Wright, EG1
Selby, PB1
Bouffler, SD; Cox, R; Fodde, R; Hofland, N1
Meister, A; Menke, M; Schubert, I1
Bello-DeOcampo, D; Bice, G; DeMendonca-Calaca, W; Kleinman, HK; Quader, ST; Storto, PD; Webber, MM; Williams, DE1
Jovtchev, G; Menke, M; Schubert, I1
Aldaz, CM; Ballenger, J; Davis, MF; El-Bayoumy, K; Li, JJ; Li, SA; Papa, D; Tawfik, O; Weroha, SJ1
Jovtchev, G; Schubert, I; Stergios, M1
Kaina, B; Rieger, R; Waller, H; Waller, M1
Frei, JV; Venitt, S1
Evseenko, LS; Fomina, MM; Minenkova, EA; Poroshenko, GG1
Nierhaus, KH; Pöche, H; Zakrzewski, S1
Seleznev, IuV1
Eisen, JD; Sanger, WG1
Bedniak, AR; Gofman, TA; Gus'kov, VF; Kalivetskaia, GM; Sokolovskaia, NB; Timoshin, SS1
Andersson, HC; Kihlman, BA1
Dasgupta, UB; Kaelbling, M; Klinger, HP; Lilly, F; Zhang, YD1
Azuma, M; Debiec-Rychter, M; Oyasu, R; Wang, CY; Zukowski, K1
Balansky, RM1
Ichikawa, T; Isaacs, JT; Kyprianou, N1
Brendler, CB; Ichikawa, T; Isaacs, JT; Squire, RA; Steinberg, GD1
Anisimov, VN; Iakovleva, TK; Monakhov, AS1
Bopp, BA; Kesterson, JW; Sonders, RC1
Granata, I; Spielmann, H; Vogel, R1
Bouffler, SD; Hatton, DH; Johnson, RT; Margison, GP; Musk, SR1
Obe, G; Rosenthal, M1
Jensen, JC; Thilly, WG1
Bogoslovskaia, EP; Fomina, MM; Korman, DB; Osatrovskaia, LA; Potapov, SL1
Carbonell, F; Eul, J; Hameister, H; Seidel, HJ1
Chen, QG; Gao, FZ; Hu, GG; Ke, Y; Liu, J; Liu, X; Luo, XM1
Bakhitova, LM; Pashin, IuV; Sal'nikova, LE1
Brennand, J; Margison, GP; Ockey, CH; White, GR1
Fichidzhian, BS; Kumkumadzhian, VA; Nersesian, AK; Zil'fian, VN1
Bogoslovskaia, EP; Fomina, MM; Konradov, AA; Ostrovskaia, LA1
Anderson, D; Challis, BC; Hopkins, AR; Massey, RC; Milligan, JR; Phillips, BJ1
Abbondandolo, A; Frosina, G1
Bodell, WJ; Wiencke, JK1
Korman, NP; Selezneva, TG1

Reviews

2 review(s) available for methylnitrosourea and Abnormalities, Autosome

ArticleYear
Toxicological aspects of cyclamate and cyclohexylamine.
    Critical reviews in toxicology, 1986, Volume: 16, Issue:3

    Topics: Abnormalities, Drug-Induced; Absorption; Adrenal Glands; Animals; Bacteria; Blood; Blood Glucose; Chick Embryo; Chromosome Aberrations; Cocarcinogenesis; Cricetinae; Cyclamates; Cyclohexylamines; Digestive System; Female; Germ Cells; Heart; Humans; In Vitro Techniques; Intestines; Kidney; Lethal Dose 50; Liver; Liver Neoplasms; Lung Neoplasms; Lymphoma, Non-Hodgkin; Macaca mulatta; Male; Methylnitrosourea; Mice; Mutagenicity Tests; Mutagens; Mutation; Neoplasms, Experimental; Pancreas; Pregnancy; Rabbits; Rats; Rats, Inbred Strains; Reproduction; Sympathomimetics; Testis; Thyroid Gland; Tissue Distribution; Urinary Bladder Neoplasms

1986
The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures.
    Mutation research, 1985, Volume: 154, Issue:2

    Topics: Alkylating Agents; Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Haplorhini; Kidney; Liver; Mammals; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mice; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Placenta; Rats

1985

Other Studies

74 other study(ies) available for methylnitrosourea and Abnormalities, Autosome

ArticleYear
Investigations on potential co-mutagenic effects of formaldehyde.
    Mutation research, 2014, Volume: 760

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylating Agents; Chromosome Aberrations; Comet Assay; Disinfectants; Drug Combinations; Drug Synergism; Formaldehyde; Gamma Rays; Humans; Lung Neoplasms; Methyl Methanesulfonate; Methylnitrosourea; Micronucleus Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2014
Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos.
    Nucleic acids research, 2008, Volume: 36, Issue:12

    Topics: Alkylating Agents; Alkylation; Animals; Cell Death; Chromosomal Instability; Chromosome Aberrations; DNA Damage; DNA Mismatch Repair; DNA Replication; DNA-Binding Proteins; Embryo, Nonmammalian; Ethylnitrosourea; Gene Deletion; Methylnitrosourea; Mutagens; Mutation; Zebrafish

2008
[Methylnitrosourea as challenge mutagen in assessment of the DNA mismatch repair (MMR) activity: association with some types of cancer].
    Genetika, 2008, Volume: 44, Issue:5

    Topics: Apoptosis; Chromosome Aberrations; Comet Assay; DNA Mismatch Repair; DNA, Neoplasm; Female; Genital Neoplasms, Female; Guanine; HeLa Cells; Humans; In Vitro Techniques; Lymphocytes; Methylnitrosourea; Microsatellite Instability; Mutagens

2008
Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice.
    Oncogene, 2011, Mar-03, Volume: 30, Issue:9

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line; Chromosome Aberrations; Disease Models, Animal; DNA Breaks, Double-Stranded; DNA Repair; DNA Replication; Flap Endonucleases; Genetic Predisposition to Disease; Hydrogen Peroxide; Lung Neoplasms; Methylnitrosourea; Mice; Mice, Mutant Strains; Microscopy, Fluorescence; Point Mutation

2011
[Cytogenetic effect of temperature on the sunflower varieties].
    Tsitologiia, 2002, Volume: 44, Issue:12

    Topics: Chromosome Aberrations; Chromosomes, Plant; Helianthus; Hot Temperature; Meristem; Methylnitrosourea; Mitotic Index; Mutagens; Time Factors

2002
[The effect of oxidative stress on nitrosomethylurea-induced mutagenesis in sunflower Helianthus annuus L].
    Genetika, 2005, Volume: 41, Issue:1

    Topics: Chromosome Aberrations; Helianthus; Hyperbaric Oxygenation; Methylnitrosourea; Mutagenesis; Mutagens; Oxidative Stress; Plastids

2005
Antigenotoxic potential of glucomannan on four model test systems.
    Cell biology and toxicology, 2004, Volume: 20, Issue:6

    Topics: 4-Nitroquinoline-1-oxide; Aminacrine; Animals; Antimutagenic Agents; Candida; Cell Division; Chlamydomonas reinhardtii; Chromosome Aberrations; Crossing Over, Genetic; DNA Damage; Mannans; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Saccharomyces cerevisiae; Salmonella typhimurium; Sodium Azide; Vicia sativa

2004
DNA copy number alterations and expression of relevant genes in mouse thymic lymphomas induced by gamma-irradiation and N-methyl-N-nitrosourea.
    Cancer genetics and cytogenetics, 2006, Apr-01, Volume: 166, Issue:1

    Topics: Alkylating Agents; Animals; Chromosome Aberrations; Chromosomes; DNA, Neoplasm; Female; Gamma Rays; Gene Dosage; Gene Expression Profiling; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasm Proteins; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Thymus Neoplasms

2006
Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens.
    Cancer research, 2007, Apr-15, Volume: 67, Issue:8

    Topics: Alkylating Agents; Cell Line; Chromosome Aberrations; DNA; DNA Adducts; DNA Damage; Ethyl Methanesulfonate; Ethylnitrosourea; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Point Mutation

2007
Multicolour FISH in an analysis of chromosome aberrations induced by N-nitroso-N-methylurea and maleic hydrazide in barley cells.
    Journal of applied genetics, 2007, Volume: 48, Issue:2

    Topics: Base Sequence; Centromere; Chromosome Aberrations; Chromosomes, Plant; DNA Probes; DNA, Plant; DNA, Ribosomal; Hordeum; In Situ Hybridization, Fluorescence; Maleic Hydrazide; Methylnitrosourea; Micronucleus Tests; Mutagens; Telomere

2007
Inhibition of DNA repair by inhibitors of nuclear ADP-ribosyl transferase.
    Nucleic acids symposium series, 1984, Issue:13

    Topics: Animals; Benzamides; Cell Nucleus; Cells, Cultured; Chromosome Aberrations; DNA Repair; Humans; Kinetics; Leukemia L1210; Methylnitrosourea; Mice; NAD; Nucleotidyltransferases; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Sister Chromatid Exchange; Xeroderma Pigmentosum

1984
Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA.
    Mutation research, 1984, Volume: 128, Issue:1

    Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Crossing Over, Genetic; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitrosourea; Mutation; Sister Chromatid Exchange; Sulfuric Acid Esters

1984
[Disruption of DNA synthesis and structure of mouse L1210 leukemia cells, sensitive and resistant to 1-methyl-1 nitrosourea and 1,3-bis(2-chloroethyl)-1-nitrosourea in vivo].
    Biokhimiia (Moscow, Russia), 1984, Volume: 49, Issue:7

    Topics: Animals; Carmustine; Centrifugation, Density Gradient; Chromosome Aberrations; DNA, Neoplasm; DNA, Single-Stranded; Drug Resistance; Leukemia L1210; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Weight; Nitrosourea Compounds; Nucleic Acid Conformation

1984
Studies on adaptation of V79 Chinese hamster cells to low doses of methylating agents.
    Carcinogenesis, 1983, Volume: 4, Issue:11

    Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Replication; Kinetics; Lung; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nitrosourea Compounds; Sister Chromatid Exchange

1983
Enhanced survival and reduced mutation and aberration frequencies induced in V79 chinese hamster cells pre-exposed to low levels of methylating agents.
    Mutation research, 1982, Volume: 93, Issue:1

    Topics: Animals; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Cricetulus; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Mutation; Nitrosourea Compounds

1982
[Comparative effectiveness of using different tests to determine the mutagenicity of certain factors in mammals. I. Frequency of dominant lethal mutations and chromosome aberrations in mouse bone marrow cells induced by N-nitrosomorpholine, N-nitroso-N-me
    Genetika, 1980, Volume: 16, Issue:6

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Female; Fetal Death; Genes, Dominant; Genes, Lethal; Hybridization, Genetic; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Morpholines; Mutagenicity Tests; Nitrosamines; Nitrosourea Compounds; Pregnancy; Spermatozoa

1980
Nitrosated urea pesticide metabolites and other nitrosamides. Activity in clastogenicity and SCE assays, and aberration kinetics in Chinese hamster V79-E cells.
    Mutation research, 1980, Volume: 79, Issue:3

    Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; Crossing Over, Genetic; Dose-Response Relationship, Drug; Ethylnitrosourea; Fibroblasts; Methylnitrosourea; Nitrosourea Compounds; Pesticides; Phenylurea Compounds; Sister Chromatid Exchange; Time Factors

1980
Cytogenetics of neoplasia of Xiphophorus.
    Cancer genetics and cytogenetics, 1981, Volume: 3, Issue:3

    Topics: Animals; Chromosome Aberrations; Crosses, Genetic; Fish Diseases; Fishes; Genes, Regulator; Karyotyping; Melanoma; Metaphase; Methylnitrosourea; Neoplasms, Experimental

1981
Cytogenetics of murine thymic lymphomas induced by N-methyl-N-nitrosourea: difference in incidence of trisomy 15 in thymic lymphomas induced in neonatal and adult mice.
    Cancer genetics and cytogenetics, 1981, Volume: 4, Issue:4

    Topics: Age Factors; Animals; Animals, Newborn; Chromosome Aberrations; Chromosome Banding; Karyotyping; Lymphoma; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Thymus Neoplasms; Trisomy

1981
Vicia faba chromosomal aberration assay.
    Mutation research, 1994, Oct-16, Volume: 310, Issue:2

    Topics: Azides; Biological Assay; Chromosome Aberrations; Fabaceae; International Cooperation; Maleic Hydrazide; Methylnitrosourea; Mutagenicity Tests; Plant Root Cap; Plants, Medicinal; Propylene Glycols; Reproducibility of Results; Sodium Azide

1994
Streptozotocin-induced genotoxic effects in Chinese hamster cells: the resistant phenotype of V79 cells.
    Mutation research, 1995, Volume: 347, Issue:2

    Topics: Animals; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Cricetulus; Methylnitrosourea; Mutation; Phenotype; Sister Chromatid Exchange; Streptozocin

1995
A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells.
    Mutation research, 1995, Volume: 346, Issue:4

    Topics: Alkylating Agents; B-Lymphocytes; Cell Line; Chromosome Aberrations; Dimethylnitrosamine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Erythroid Precursor Cells; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea

1995
[Modification of hereditary and non-hereditary variations by antimutagens].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1995, Issue:1

    Topics: Air Pollutants; Animals; Antimutagenic Agents; Chromosome Aberrations; Drosophila; Genetic Variation; Methylnitrosourea; Mutagenesis; Plants; Vitamin E

1995
Hypersomy of chromosome 15 with retrovirally rearranged c-myc, loss of germline c-myc and IgK/c-myc juxtaposition in a macrophage-monocytic tumour line.
    European journal of cancer (Oxford, England : 1990), 1994, Volume: 30A, Issue:7

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Northern; Blotting, Southern; Chromosome Aberrations; Chromosomes, Human, Pair 15; Electrophoresis, Gel, Pulsed-Field; Genes, myc; Humans; Lymphoma, T-Cell; Macrophages; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Monocytes; Trisomy; Tumor Cells, Cultured

1994
Alteration of the DCC tumor-suppressor gene in tumorigenic HPV-18 immortalized human keratinocytes transformed by nitrosomethylurea.
    Oncogene, 1993, Volume: 8, Issue:1

    Topics: Adenomatous Polyposis Coli; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chromosome Aberrations; Gene Deletion; Genes, DCC; Humans; Keratinocytes; Methylnitrosourea; Papillomaviridae

1993
Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents.
    Mutation research, 1997, Feb-03, Volume: 373, Issue:2

    Topics: Alkylating Agents; Animals; Cell Division; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Enzyme Inhibitors; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Thioguanine

1997
Malignant transformation of human prostate epithelial cells by N-nitroso-N-methylurea.
    Cancer research, 1997, Feb-15, Volume: 57, Issue:4

    Topics: Adult; Animals; Carcinogens; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Disorders; Humans; Karyotyping; Male; Methylnitrosourea; Mice; Mice, Nude; Neoplasm Proteins; Prostate; ras Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1997
Allium cepa anaphase-telophase root tip chromosome aberration assay on N-methyl-N-nitrosourea, maleic hydrazide, sodium azide, and ethyl methanesulfonate.
    Mutation research, 1997, Apr-24, Volume: 390, Issue:1-2

    Topics: Allium; Anaphase; Arabidopsis; Azides; Chromosome Aberrations; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Maleic Hydrazide; Methylnitrosourea; Micronucleus Tests; Mutagenicity Tests; Mutagens; Plant Roots; Plants; Sodium Azide; Telophase

1997
[Mutagenic effect of nitrosodimethylurea in male mice. Induction of dominant lethal mutations and chromosome aberrations in germ cells; genotype influence on the clastogenic effect in bone marrow cells].
    Genetika, 1997, Volume: 33, Issue:4

    Topics: Animals; Bone Marrow; Chromosome Aberrations; Genes, Dominant; Genes, Lethal; Genotype; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mutagenicity Tests; Mutagens; Spermatogonia; Spermatozoa

1997
Removal of O6-methylguanine from plant DNA in vivo is accelerated under conditions of clastogenic adaptation.
    Environmental and molecular mutagenesis, 1997, Volume: 29, Issue:4

    Topics: Adaptation, Physiological; Alkylating Agents; Chromosome Aberrations; DNA Adducts; DNA Damage; DNA, Plant; Fabaceae; Guanine; Immunoblotting; Meristem; Methylnitrosourea; Mutagens; Plants, Medicinal

1997
Formation and repair of O6-methylguanine in recombination hot spots of plant chromosomes.
    Environmental and molecular mutagenesis, 1997, Volume: 29, Issue:4

    Topics: Alkylating Agents; Chromatids; Chromosome Aberrations; Chromosomes; Deoxyribonucleases, Type II Site-Specific; DNA Repair; DNA, Plant; Fabaceae; Guanine; Immunoblotting; Meristem; Methylnitrosourea; Mutagens; Plant Roots; Plants, Medicinal; Recombination, Genetic; Repetitive Sequences, Nucleic Acid

1997
[Genetic analysis on methylnitrosourea (MNU) induced mouse T-cell lymphomas].
    Yi chuan xue bao = Acta genetica Sinica, 1997, Volume: 24, Issue:3

    Topics: Animals; Chromosome Aberrations; Lymphoma, T-Cell; Male; Methylnitrosourea; Mice

1997
[The influence of melatonin on mutagenicity and antitumor action of cytostatic drugs in mice].
    Voprosy onkologii, 1997, Volume: 43, Issue:6

    Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Male; Melatonin; Methylnitrosourea; Mice; Mice, Inbred Strains; Mutagenesis; Mutagens; Neoplasms, Experimental; Sperm Head

1997
Tumour induction by methyl-nitroso-urea following preconceptional paternal contamination with plutonium-239.
    British journal of cancer, 1998, Volume: 78, Issue:3

    Topics: Animals; Bone Marrow Cells; Cell Count; Chromosome Aberrations; Colony-Forming Units Assay; Female; Leukemia, Experimental; Lymphoma; Male; Methylnitrosourea; Mice; Mice, Inbred CBA; Mice, Inbred DBA; Paternal Exposure; Plutonium; Spermatozoa; Spleen; Thymus Neoplasms; Time Factors

1998
Critical steps in alkylation-induced aberration formation.
    Mutation research, 1998, Aug-03, Volume: 404, Issue:1-2

    Topics: Alkylating Agents; Animals; Cell Cycle; Chromosome Aberrations; DNA Damage; DNA Repair; DNA Replication; Fibroblasts; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Nucleic Acid Synthesis Inhibitors; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Sister Chromatid Exchange

1998
A short-term assessment of tumor-promotion activity in the livers of rats treated with two genotoxic methylating agents: dimethylnitrosamine and methylnitrosourea.
    Toxicology letters, 1998, Sep-15, Volume: 98, Issue:3

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Dimethylnitrosamine; DNA Replication; Liver; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344

1998
Induction of lympho-haemopoietic malignancy: impact of preconception paternal irradiation.
    International journal of radiation biology, 1998, Volume: 74, Issue:6

    Topics: Animals; Carcinogens; Cells, Cultured; Chromosome Aberrations; Colony-Forming Units Assay; Female; Gamma Rays; Leukemia, Experimental; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Mutagens; Neoplasms, Radiation-Induced; Paternal Exposure; Plutonium; Pregnancy; Prenatal Exposure Delayed Effects; Spleen; Whole-Body Irradiation

1998
Reasons it is doubtful that preconceptional paternal irradiation with plutonium-239 had any effect on cancer induction by methyl-nitroso-urea.
    British journal of cancer, 1999, Volume: 81, Issue:6

    Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Chromosome Aberrations; DNA Damage; Male; Methylnitrosourea; Mice; Neoplasms; Paternal Exposure; Plutonium; Reproducibility of Results

1999
Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis.
    British journal of cancer, 2000, Volume: 83, Issue:10

    Topics: Animals; Base Pair Mismatch; Chromosome Aberrations; Chromosome Fragility; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Disease Models, Animal; DNA Repair; DNA-Binding Proteins; Genetic Predisposition to Disease; Haplotypes; Loss of Heterozygosity; Methylnitrosourea; Mice; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Radiation, Ionizing; Sister Chromatid Exchange

2000
N-Methyl-N-nitrosourea-induced DNA damage detected by the comet assay in Vicia faba nuclei during all interphase stages is not restricted to chromatid aberration hot spots.
    Mutagenesis, 2000, Volume: 15, Issue:6

    Topics: Alkylating Agents; Cell Cycle; Cell Nucleus; Cell Separation; Chromatids; Chromosome Aberrations; Chromosomes; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis; Flow Cytometry; In Situ Hybridization, Fluorescence; Interphase; Methylnitrosourea; Plants

2000
Human cell lines as an in vitro/in vivo model for prostate carcinogenesis and progression.
    The Prostate, 2001, Volume: 47, Issue:1

    Topics: Alkylating Agents; Animals; Carcinogenicity Tests; Cell Adhesion; Cell Culture Techniques; Cell Division; Chromosome Aberrations; Chromosome Disorders; Disease Progression; Dose-Response Relationship, Drug; Epidermal Growth Factor; Humans; Keratins; Male; Methylnitrosourea; Mice; Mice, Nude; Nandrolone; Neoplasm Invasiveness; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Transforming Growth Factor beta; Tumor Cells, Cultured

2001
The comet assay detects adaptation to MNU-induced DNA damage in barley.
    Mutation research, 2001, Jun-27, Volume: 493, Issue:1-2

    Topics: Alkylating Agents; Aneuploidy; Cadmium Chloride; Chromosome Aberrations; Comet Assay; DNA Damage; Hordeum; Methylnitrosourea; Micronuclei, Chromosome-Defective

2001
Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer.
    Molecular carcinogenesis, 2002, Volume: 33, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blotting, Southern; Breast Neoplasms; Carcinogens; Carcinoma in Situ; Carcinoma, Ductal, Breast; Chromosome Aberrations; DNA, Neoplasm; Estrogens; Female; Genes, myc; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Male; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Invasiveness; Ploidies; Rats; Rats, Inbred ACI; Rats, Sprague-Dawley; Testosterone

2002
A comparison of N-methyl-N-nitrosourea-induced chromatid aberrations and micronuclei in barley meristems using FISH techniques.
    Mutation research, 2002, May-27, Volume: 517, Issue:1-2

    Topics: Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Hordeum; In Situ Hybridization, Fluorescence; Methylnitrosourea; Micronucleus Tests; Mutagens; Time Factors

2002
The action of N-methyl-N-nitrosourea on non-established human cell lines in vitro. I. Cell cycle inhibition and aberration induction in diploid and Down's fibroblasts.
    Mutation research, 1977, Volume: 43, Issue:3

    Topics: Cell Division; Cell Line; Chromatids; Chromosome Aberrations; Chromosomes; Chromosomes, Human, 21-22 and Y; Diploidy; DNA; Down Syndrome; Fibroblasts; Humans; Methylnitrosourea; Nitrosourea Compounds; Trisomy

1977
The action of N-methyl-N-nitrosourea on non-established human cell lines in vitro. II. Non-random distribution of chromatid aberrations in diploid and Down's cells.
    Mutation research, 1977, Volume: 43, Issue:3

    Topics: Cell Division; Cell Line; Chromatids; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; Diploidy; Down Syndrome; Fibroblasts; Humans; Karyotyping; Methylnitrosourea; Nitrosourea Compounds; Trisomy

1977
Chromosome damage in the bone marrow of mice treated with the methylating agents methyl methanesulphonate and N-methyl-N-nitrosourea in the presence or absence of caffeine, and its relationship with thymoma induction.
    Mutation research, 1975, Volume: 30, Issue:1

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Caffeine; Chromosome Aberrations; Chromosome Deletion; Chromosomes; Drug Synergism; Female; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mutagens; Nitrosourea Compounds; Specific Pathogen-Free Organisms; Thymoma; Thymus Neoplasms

1975
[Polymorphism of a tumor ce-l population and selection processes. IV. The effect of dibunol and nitrosourea on the variability of Ehrlich-I. Ch. Ph. ascitic strain tumor cells].
    Tsitologiia, 1979, Volume: 21, Issue:9

    Topics: Animals; Butylated Hydroxytoluene; Carcinoma, Ehrlich Tumor; Chromosome Aberrations; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genetic Markers; Genetic Variation; Methylnitrosourea; Mice; Mitosis; Neoplasm Transplantation; Nitrosourea Compounds; Polymorphism, Genetic; Selection, Genetic; Time Factors

1979
Cycloheximide-resistance in Chinese hamster ovary cells and human fibroblast cells. Cytogenetic and biochemical characterization.
    Human genetics, 1979, Volume: 50, Issue:3

    Topics: Animals; Cell Division; Cell Line; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cycloheximide; Drug Resistance; Ethyl Methanesulfonate; Female; Fibroblasts; Humans; Karyotyping; Methylnitrosourea; Mutation; Ovary; Protein Biosynthesis

1979
[Combined effect of N-nitroso-N-methylurea and actinomycin D on Chinese hamster cell chromosomes].
    Genetika, 1976, Volume: 12, Issue:3

    Topics: Chromosome Aberrations; Chromosomes; Clone Cells; Dactinomycin; Methylnitrosourea; Nitrosourea Compounds

1976
Clastogenic effects of methylnitrosourea and ethylnitrosourea on chromosomes from human fibroblast cell lines.
    Mutation research, 1976, Volume: 34, Issue:3

    Topics: Cell Line; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Ethylnitrosourea; Methylnitrosourea; Mitotic Index; Nitrosourea Compounds

1976
[The protective action of sodium thiosulfate in cytogenetic experiments with 1,3-dimethyl-1-nitrosourea on rats].
    Voprosy onkologii, 1992, Volume: 38, Issue:9

    Topics: Animals; Chelating Agents; Chromosome Aberrations; Drug Interactions; Endothelium, Corneal; Male; Methylnitrosourea; Mitosis; Mutagens; Rats; Thiosulfates; Time Factors

1992
Enhancement and reduction by methylated oxypurines of the frequencies of chromatid aberrations induced by camptothecin in root-tip cells of Vicia faba.
    Mutation research, 1992, Volume: 269, Issue:2

    Topics: Caffeine; Camptothecin; Chromatids; Chromosome Aberrations; Dose-Response Relationship, Drug; Methylnitrosourea; Mutagenicity Tests; Mutagens; Plants; Purines; Theophylline; Uric Acid

1992
Nonrandom chromosome changes in methylnitrosourea (MNU) induced mouse T-cell lymphomas.
    Annales de genetique, 1991, Volume: 34, Issue:3-4

    Topics: Animals; Chromosome Aberrations; Chromosome Disorders; Female; Karyotyping; Lymphoma, T-Cell; Methylnitrosourea; Mice; Mice, Inbred Strains; Mice, Nude; Thymus Gland

1991
Specific chromosome change associated with acquisition in vivo of tumorigenicity in carcinogen-induced rat urinary bladder carcinoma cells.
    Genes, chromosomes & cancer, 1991, Volume: 3, Issue:3

    Topics: Animals; Cell Line; Chromosome Aberrations; Chromosome Banding; Chromosome Disorders; Diploidy; Genetic Markers; Karyotyping; Male; Methylnitrosourea; Neoplasm Transplantation; Probability; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms

1991
Comutagenic and coclastogenic effects of selenium in vitro and in vivo.
    Mutation research, 1991, Volume: 263, Issue:4

    Topics: Animals; Cell Line; Chromosome Aberrations; Erythrocytes; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Micronucleus Tests; Microsomes; Mitomycin; Mitomycins; Mutagenesis; Mutagens; Salmonella typhimurium; Selenium; Urethane

1991
Genetic instability and the acquisition of metastatic ability by rat mammary cancer cells following v-H-ras oncogene transfection.
    Cancer research, 1990, Oct-01, Volume: 50, Issue:19

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Chromosome Aberrations; Chromosome Disorders; DNA, Neoplasm; Female; Genes, ras; Karyotyping; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Metastasis; Ploidies; Rats; Rats, Inbred Strains; Transfection

1990
Characterization of an N-methyl-N-nitrosourea-induced autochthonous rat bladder cancer model.
    Cancer research, 1990, Oct-15, Volume: 50, Issue:20

    Topics: Animals; Carcinoma, Transitional Cell; Cell Transformation, Neoplastic; Chromosome Aberrations; Disease Models, Animal; FANFT; Female; Methylnitrosourea; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344; Urinary Bladder Neoplasms

1990
[Chromosomal damage in peripheral blood lymphocytes of rats in nitrosomethylurea-induced carcinogenesis].
    Eksperimental'naia onkologiia, 1990, Volume: 12, Issue:6

    Topics: Aneuploidy; Animals; Chromosome Aberrations; Female; Lymphocytes; Methylnitrosourea; Neoplasms, Experimental; Polyploidy; Prognosis; Rats

1990
Cytogenetic studies on preimplantation mouse embryos exposed to methylnitrosourea in vivo.
    Reproductive toxicology (Elmsford, N.Y.), 1989, Volume: 3, Issue:1

    Topics: Animals; Blastocyst; Chromosome Aberrations; Chromosome Disorders; Female; Methylnitrosourea; Mice; Morula; Pregnancy; Sister Chromatid Exchange

1989
Molecular mechanisms of alkylation sensitivity in Indian muntjac cell lines.
    Carcinogenesis, 1989, Volume: 10, Issue:7

    Topics: Alkylating Agents; Alkylation; Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromosome Aberrations; Deer; DNA Damage; Kinetics; Methylnitrosourea; Simian virus 40; Sister Chromatid Exchange; Sulfuric Acid Esters; Sulfuric Acids

1989
General models for the generation and suppression of malignancy.
    Ciba Foundation symposium, 1989, Volume: 142

    Topics: Animals; Chromosome Aberrations; Clone Cells; Gene Amplification; Gene Expression Regulation; Genes, Dominant; Genes, Recessive; Genetic Markers; Karyotyping; Lymphoma; Methylnitrosourea; Mice; Models, Genetic; Mutation; Neoplasms, Experimental; Oncogenes; Proto-Oncogenes; Suppression, Genetic

1989
Effects of 50-hertz electromagnetic fields on proliferation and on chromosomal alterations in human peripheral lymphocytes untreated or pretreated with chemical mutagens.
    Mutation research, 1989, Volume: 210, Issue:2

    Topics: Alkylating Agents; Cell Division; Cells, Cultured; Chromosome Aberrations; Chromosomes; Epoxy Compounds; In Vitro Techniques; Lymphocytes; Methylnitrosourea; Mutagens; Radiation, Nonionizing; Sister Chromatid Exchange; Temperature; Triaziquone

1989
Spontaneous and induced chromosomal aberrations and gene mutations in human lymphoblasts: mitomycin C, methylnitrosourea, and ethylnitrosourea.
    Mutation research, 1986, Volume: 160, Issue:2

    Topics: Cell Line; Cell Survival; Chromosome Aberrations; Dose-Response Relationship, Drug; Ethylnitrosourea; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Methylnitrosourea; Mitomycin; Mitomycins; Mutation; Thymidine Kinase

1986
[Comparative evaluation of the antitumor, cytogenetic and immunodepressive effects of dimetinur when used perorally and parenterally].
    Eksperimental'naia onkologiia, 1988, Volume: 10, Issue:6

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Chromosome Aberrations; Drug Evaluation, Preclinical; Immunity, Cellular; Immunosuppressive Agents; Injections, Intraperitoneal; Metaphase; Methylnitrosourea; Mice; Mice, Inbred Strains; Mutagens; Neoplasms, Experimental; Rats

1988
Cytogenetics of preleukemic stages in experimental and human leukemogenesis.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1988, Volume: 106

    Topics: Aged; Animals; Chromosome Aberrations; Chromosomes, Human, Pair 15; Humans; Leukemia; Leukemia, Experimental; Methylnitrosourea; Mice; Middle Aged; Preleukemia; T-Lymphocytes

1988
[Effect of sodium selenite on the chromosomal aberration of V 79 cells induced in vitro by MNNG and MNU].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 1987, Volume: 9, Issue:1

    Topics: Animals; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Fibroblasts; Lung; Methylnitronitrosoguanidine; Methylnitrosourea; Selenic Acid; Selenium; Selenium Compounds

1987
[Effect of alkylation and carbamoylation on the characteristics of genetic damage to mammalian somatic cells cultured in vitro].
    Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 105, Issue:1

    Topics: Animals; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Methylnitrosourea; Mutation; Time Factors

1988
Chinese hamster cells harbouring the Escherichia coli O6-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents.
    Carcinogenesis, 1986, Volume: 7, Issue:12

    Topics: Alkylating Agents; Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Escherichia coli; Guanine; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange

1986
[Effect of the immunization of rats with tularemia vaccine on the number of cytogenetic disorders in somatic cells induced by cytostatics].
    Tsitologiia, 1986, Volume: 28, Issue:4

    Topics: Animals; Antineoplastic Agents; Bacterial Vaccines; Bone Marrow; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Francisella tularensis; Immunization; Male; Metaphase; Methylnitrosourea; Rats; Rats, Inbred Strains

1986
[Dynamics of the chromosomal damages to Ehrlich ascitic cancer and bone marrow cells of mice by the antitumor preparation dimetinur].
    Eksperimental'naia onkologiia, 1986, Volume: 8, Issue:3

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Carcinoma, Ehrlich Tumor; Chromosome Aberrations; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Methylnitrosourea; Mice; Neoplasm Transplantation; Nitrosourea Compounds; Time Factors

1986
Mutagenic properties of N-nitrosopeptides in mammalian cell culture assays.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1986, Volume: 24, Issue:4

    Topics: Animals; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Female; Metaphase; Methylnitrosourea; Mutagenicity Tests; Nitrosamines; Ovary; Sister Chromatid Exchange

1986
N-Methyl-N-nitrosourea potentiation of cytogenetic damage induced by 1,3-bis(2-chloroethyl)-1-nitrosourea in normal human lymphocytes.
    Cancer research, 1985, Volume: 45, Issue:10

    Topics: Carmustine; Cell Cycle; Chromosome Aberrations; Drug Synergism; Humans; Lymphocytes; Methylnitrosourea; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange

1985
[Analysis of somatic cell chromosomes in patients treated with antineoplastic agents].
    Genetika, 1973, Volume: 9, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Cyclophosphamide; Female; Humans; Lymphocytes; Male; Methylnitrosourea; Middle Aged; Thiotepa

1973