methylnitronitrosoguanidine and Tuberculosis--Pulmonary

methylnitronitrosoguanidine has been researched along with Tuberculosis--Pulmonary* in 1 studies

Other Studies

1 other study(ies) available for methylnitronitrosoguanidine and Tuberculosis--Pulmonary

Article	Year
DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis. Infection and immunity, 2003, Volume: 71, Issue:2 One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine in vitro, the mutants displayed no phenotype in vivo, suggesting that permeation of nitrosative stress to the level of cytotoxic DNA damage is restricted. Topics: Alkylation; Animals; DNA Damage; DNA, Bacterial; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mutation; Mycobacterium tuberculosis; Nitrate Reductases; Nitrates; Nitrosation; Tuberculosis, Pulmonary; Virulence	2003

Article

Year

DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis.

Infection and immunity, 2003, Volume: 71, Issue:2

One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine in vitro, the mutants displayed no phenotype in vivo, suggesting that permeation of nitrosative stress to the level of cytotoxic DNA damage is restricted.

Topics: Alkylation; Animals; DNA Damage; DNA, Bacterial; Methylnitronitrosoguanidine; Mice; Mice, Inbred C57BL; Mutation; Mycobacterium tuberculosis; Nitrate Reductases; Nitrates; Nitrosation; Tuberculosis, Pulmonary; Virulence

2003