methylnitronitrosoguanidine and Carcinoma--Ehrlich-Tumor

methylnitronitrosoguanidine has been researched along with Carcinoma--Ehrlich-Tumor* in 1 studies

Other Studies

1 other study(ies) available for methylnitronitrosoguanidine and Carcinoma--Ehrlich-Tumor

Article	Year
Effect of N-methyl-N'-nitro-N-nitrosoguanidine on DNA polymerases alpha and beta in vitro. FEBS letters, 1983, Nov-28, Volume: 164, Issue:1 DNA polymerases alpha and beta were treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The activities of the modified DNA polymerase were decreased and the degree of lowered activity varied with the template employed. However, no decrease in fidelity was observed in DNA synthesis by the MNNG-treated polymerases. It is suggested that direct modification of the DNA polymerase molecule by MNNG is not the cause of carcinogenesis. Topics: Animals; Carcinoma, Ehrlich Tumor; DNA Polymerase I; DNA Polymerase II; DNA Replication; Kinetics; Methylnitronitrosoguanidine; Mice; Polydeoxyribonucleotides; Structure-Activity Relationship	1983

Article

Year

Effect of N-methyl-N'-nitro-N-nitrosoguanidine on DNA polymerases alpha and beta in vitro.

FEBS letters, 1983, Nov-28, Volume: 164, Issue:1

DNA polymerases alpha and beta were treated with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The activities of the modified DNA polymerase were decreased and the degree of lowered activity varied with the template employed. However, no decrease in fidelity was observed in DNA synthesis by the MNNG-treated polymerases. It is suggested that direct modification of the DNA polymerase molecule by MNNG is not the cause of carcinogenesis.

Topics: Animals; Carcinoma, Ehrlich Tumor; DNA Polymerase I; DNA Polymerase II; DNA Replication; Kinetics; Methylnitronitrosoguanidine; Mice; Polydeoxyribonucleotides; Structure-Activity Relationship

1983