methylmercaptan has been researched along with Hepatic Encephalopathy in 11 studies
methylmercaptan: intermediate in the manufacturing of jet fuels, pesticides, fungicides, plastics, synthesis of methionine; odor may cause nausea; narcotic in high concentrations; depresses urea biosynthesis; RN given refers to parent cpd; structure
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The concentrations of methanethiol-mixed disulfides, methionine, 4-methylthio-2-oxobutyrate and ammonia were measured in patients with different stages of hepatic encephalopathy, in patients with chronic kidney failure and in healthy subjects." | 3.68 | The role of methanethiol in the pathogenesis of hepatic encephalopathy. ( Blom, HJ; Ferenci, P; Grimm, G; Tangerman, A; Yap, SH, 1991) |
| "Rats with acute hepatic encephalopathy caused by liver ischemia also showed elevation of methanethiol mixed disulfide levels on challenge of methanethiol through the colon or inspired air, but to a significantly smaller extent than did the corresponding sham-operated rats." | 1.28 | Methanethiol metabolism and its role in the pathogenesis of hepatic encephalopathy in rats and dogs. ( Blom, HJ; Chamuleau, RA; Deutz, NE; Rothuizen, J; Tangerman, A, 1990) |
| " These results indicate that no differential exists with respect to the dose-response of these two activities associated with human erythrocyte membrane." | 1.27 | Effects of methanethiol on erythrocyte membrane stabilization and on Na+,K+-adenosine triphosphatase: relevance to hepatic coma. ( Ahmed, K; Quarfoth, G; Zieve, L, 1984) |
| "Rats in octanoate or hepatic coma excreted only little sulfate in their urine." | 1.27 | Methanethiol metabolism in the rat. ( Derr, RF; Draves, K, 1983) |
| " When various smaller dosage combinations of NH+4, methanethiol, and octanoic acid were injected simultaneously, coma occurred at lower brain and blood concentrations of ammonia and methanethiol." | 1.27 | Brain methanethiol and ammonia concentrations in experimental hepatic coma and coma induced by injections of various combinations of these substances. ( Doizaki, WM; Lyftogt, C; Zieve, L, 1984) |
| "In one patient with chronic hepatic encephalopathy there was no significant change in methanethiol, dimethyl sulphide or ammonia concentration 4 h after methionine when conscious state had deteriorated by two stages of encephalopathy." | 1.27 | Effect of methionine loading and endogenous hypermethioninaemia on blood mercaptans in man. ( Al Mardini, H; Bartlett, K; Leonard, J; Lloyd, S; Record, CO, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, K | 1 |
| Zieve, L | 4 |
| Quarfoth, G | 1 |
| Derr, RF | 1 |
| Draves, K | 1 |
| Doizaki, WM | 3 |
| Lyftogt, C | 1 |
| Al Mardini, H | 2 |
| Bartlett, K | 2 |
| Record, CO | 2 |
| Gundermann, KJ | 1 |
| Uhlhaas, S | 1 |
| Grünn, U | 1 |
| Olek, K | 1 |
| Ukigusa, M | 1 |
| Lie, TS | 1 |
| Kromhout, J | 1 |
| McClain, CJ | 2 |
| Gilberstadt, S | 2 |
| Hisamura, M | 1 |
| Onstad, GR | 1 |
| Blom, HJ | 2 |
| Ferenci, P | 1 |
| Grimm, G | 1 |
| Yap, SH | 1 |
| Tangerman, A | 2 |
| Chamuleau, RA | 1 |
| Rothuizen, J | 1 |
| Deutz, NE | 1 |
| Leonard, J | 1 |
| Lloyd, S | 1 |
11 other studies available for methylmercaptan and Hepatic Encephalopathy
| Article | Year |
|---|---|
Effects of methanethiol on erythrocyte membrane stabilization and on Na+,K+-adenosine triphosphatase: relevance to hepatic coma.
Topics: Animals; Erythrocyte Membrane; Hemolysis; Hepatic Encephalopathy; Humans; In Vitro Techniques; Rats; | 1984 |
Methanethiol metabolism in the rat.
Topics: Animals; Carbon Dioxide; Hepatic Encephalopathy; Male; Oxidation-Reduction; Rats; Rats, Inbred Strai | 1983 |
Brain methanethiol and ammonia concentrations in experimental hepatic coma and coma induced by injections of various combinations of these substances.
Topics: Ammonia; Ammonium Chloride; Animals; Brain Chemistry; Caprylates; Coma; Dose-Response Relationship, | 1984 |
Blood and brain concentrations of mercaptans in hepatic and methanethiol induced coma.
Topics: Ammonia; Animals; Brain Chemistry; Coma; Hepatic Encephalopathy; Humans; Liver Diseases; Methionine; | 1984 |
Comparison of a charcoal sorbent fiber with commercial charcoals for hemoperfusion.
Topics: Adsorption; Amino Acids; Animals; Biocompatible Materials; Charcoal; Dogs; Hemolysis; Hemoperfusion; | 1983 |
Blood mercaptan and ammonia concentrations in cirrhotics after a protein load.
Topics: Adult; Ammonia; Dietary Proteins; Hepatic Encephalopathy; Humans; Liver Cirrhosis, Alcoholic; Male; | 1980 |
[The role of methyl mercaptan and dimethyl sulfide in the expired alveolar gas in patients with hepatic coma (author's transl)].
Topics: Adult; Aged; Ammonia; Breath Tests; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged; Pulmo | 1981 |
Blood methanethiol in alcoholic liver disease with and without hepatic encephalopathy.
Topics: Adult; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Diseases, Alcoholic; Male; Middl | 1980 |
The role of methanethiol in the pathogenesis of hepatic encephalopathy.
Topics: Adult; Ammonia; Disulfides; Female; Hepatic Encephalopathy; Humans; Liver Diseases; Male; Methionine | 1991 |
Methanethiol metabolism and its role in the pathogenesis of hepatic encephalopathy in rats and dogs.
Topics: Administration, Inhalation; Ammonia; Animals; Colon; Disulfides; Dogs; Hepatic Encephalopathy; Injec | 1990 |
Effect of methionine loading and endogenous hypermethioninaemia on blood mercaptans in man.
Topics: Hepatic Encephalopathy; Humans; Liver Cirrhosis; Methionine; Sulfhydryl Compounds; Sulfides | 1988 |