Page last updated: 2024-10-19

methylmercaptan and Hepatic Encephalopathy

methylmercaptan has been researched along with Hepatic Encephalopathy in 11 studies

methylmercaptan: intermediate in the manufacturing of jet fuels, pesticides, fungicides, plastics, synthesis of methionine; odor may cause nausea; narcotic in high concentrations; depresses urea biosynthesis; RN given refers to parent cpd; structure

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
" The concentrations of methanethiol-mixed disulfides, methionine, 4-methylthio-2-oxobutyrate and ammonia were measured in patients with different stages of hepatic encephalopathy, in patients with chronic kidney failure and in healthy subjects."3.68The role of methanethiol in the pathogenesis of hepatic encephalopathy. ( Blom, HJ; Ferenci, P; Grimm, G; Tangerman, A; Yap, SH, 1991)
"Rats with acute hepatic encephalopathy caused by liver ischemia also showed elevation of methanethiol mixed disulfide levels on challenge of methanethiol through the colon or inspired air, but to a significantly smaller extent than did the corresponding sham-operated rats."1.28Methanethiol metabolism and its role in the pathogenesis of hepatic encephalopathy in rats and dogs. ( Blom, HJ; Chamuleau, RA; Deutz, NE; Rothuizen, J; Tangerman, A, 1990)
" These results indicate that no differential exists with respect to the dose-response of these two activities associated with human erythrocyte membrane."1.27Effects of methanethiol on erythrocyte membrane stabilization and on Na+,K+-adenosine triphosphatase: relevance to hepatic coma. ( Ahmed, K; Quarfoth, G; Zieve, L, 1984)
"Rats in octanoate or hepatic coma excreted only little sulfate in their urine."1.27Methanethiol metabolism in the rat. ( Derr, RF; Draves, K, 1983)
" When various smaller dosage combinations of NH+4, methanethiol, and octanoic acid were injected simultaneously, coma occurred at lower brain and blood concentrations of ammonia and methanethiol."1.27Brain methanethiol and ammonia concentrations in experimental hepatic coma and coma induced by injections of various combinations of these substances. ( Doizaki, WM; Lyftogt, C; Zieve, L, 1984)
"In one patient with chronic hepatic encephalopathy there was no significant change in methanethiol, dimethyl sulphide or ammonia concentration 4 h after methionine when conscious state had deteriorated by two stages of encephalopathy."1.27Effect of methionine loading and endogenous hypermethioninaemia on blood mercaptans in man. ( Al Mardini, H; Bartlett, K; Leonard, J; Lloyd, S; Record, CO, 1988)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19909 (81.82)18.7374
1990's2 (18.18)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ahmed, K1
Zieve, L4
Quarfoth, G1
Derr, RF1
Draves, K1
Doizaki, WM3
Lyftogt, C1
Al Mardini, H2
Bartlett, K2
Record, CO2
Gundermann, KJ1
Uhlhaas, S1
GrĂ¼nn, U1
Olek, K1
Ukigusa, M1
Lie, TS1
Kromhout, J1
McClain, CJ2
Gilberstadt, S2
Hisamura, M1
Onstad, GR1
Blom, HJ2
Ferenci, P1
Grimm, G1
Yap, SH1
Tangerman, A2
Chamuleau, RA1
Rothuizen, J1
Deutz, NE1
Leonard, J1
Lloyd, S1

Other Studies

11 other studies available for methylmercaptan and Hepatic Encephalopathy

ArticleYear
Effects of methanethiol on erythrocyte membrane stabilization and on Na+,K+-adenosine triphosphatase: relevance to hepatic coma.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 228, Issue:1

    Topics: Animals; Erythrocyte Membrane; Hemolysis; Hepatic Encephalopathy; Humans; In Vitro Techniques; Rats;

1984
Methanethiol metabolism in the rat.
    Research communications in chemical pathology and pharmacology, 1983, Volume: 39, Issue:3

    Topics: Animals; Carbon Dioxide; Hepatic Encephalopathy; Male; Oxidation-Reduction; Rats; Rats, Inbred Strai

1983
Brain methanethiol and ammonia concentrations in experimental hepatic coma and coma induced by injections of various combinations of these substances.
    The Journal of laboratory and clinical medicine, 1984, Volume: 104, Issue:5

    Topics: Ammonia; Ammonium Chloride; Animals; Brain Chemistry; Caprylates; Coma; Dose-Response Relationship,

1984
Blood and brain concentrations of mercaptans in hepatic and methanethiol induced coma.
    Gut, 1984, Volume: 25, Issue:3

    Topics: Ammonia; Animals; Brain Chemistry; Coma; Hepatic Encephalopathy; Humans; Liver Diseases; Methionine;

1984
Comparison of a charcoal sorbent fiber with commercial charcoals for hemoperfusion.
    Artificial organs, 1983, Volume: 7, Issue:2

    Topics: Adsorption; Amino Acids; Animals; Biocompatible Materials; Charcoal; Dogs; Hemolysis; Hemoperfusion;

1983
Blood mercaptan and ammonia concentrations in cirrhotics after a protein load.
    The American journal of gastroenterology, 1980, Volume: 74, Issue:6

    Topics: Adult; Ammonia; Dietary Proteins; Hepatic Encephalopathy; Humans; Liver Cirrhosis, Alcoholic; Male;

1980
[The role of methyl mercaptan and dimethyl sulfide in the expired alveolar gas in patients with hepatic coma (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1981, Dec-01, Volume: 78, Issue:12

    Topics: Adult; Aged; Ammonia; Breath Tests; Female; Hepatic Encephalopathy; Humans; Male; Middle Aged; Pulmo

1981
Blood methanethiol in alcoholic liver disease with and without hepatic encephalopathy.
    Gut, 1980, Volume: 21, Issue:4

    Topics: Adult; Aged; Ammonia; Female; Hepatic Encephalopathy; Humans; Liver Diseases, Alcoholic; Male; Middl

1980
The role of methanethiol in the pathogenesis of hepatic encephalopathy.
    Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:3

    Topics: Adult; Ammonia; Disulfides; Female; Hepatic Encephalopathy; Humans; Liver Diseases; Male; Methionine

1991
Methanethiol metabolism and its role in the pathogenesis of hepatic encephalopathy in rats and dogs.
    Hepatology (Baltimore, Md.), 1990, Volume: 11, Issue:4

    Topics: Administration, Inhalation; Ammonia; Animals; Colon; Disulfides; Dogs; Hepatic Encephalopathy; Injec

1990
Effect of methionine loading and endogenous hypermethioninaemia on blood mercaptans in man.
    Clinica chimica acta; international journal of clinical chemistry, 1988, Aug-15, Volume: 176, Issue:1

    Topics: Hepatic Encephalopathy; Humans; Liver Cirrhosis; Methionine; Sulfhydryl Compounds; Sulfides

1988