methylmalonic acid has been researched along with Sensitivity and Specificity in 46 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We compared the sensitivity and specificity of the two metabolite tests, methylmalonic acid (MMA) and total homocysteine (Hcy) in serum, and serum cobalamin (Cbl) in patients referred to our hospital because of suspected cobalamin deficiency and a serum cobalamin value at the referring unit <200 pmol/L." | 3.69 | Serum methylmalonic acid and total homocysteine in patients with suspected cobalamin deficiency: a clinical study based on gastrointestinal histopathological findings. ( Johansson, KW; Kilander, AF; Lindgren, A; Nilsson, O; Swolin, B, 1997) |
| "Nearly all patients with vitamin B12 deficiency also have substantially increased levels of methylmalonic acid and homocysteine." | 2.43 | [Diagnosis of vitamin B12 deficiency revised]. ( de Rooij, SE; Fischer, C; Hoekstra, JB; Huijmans, JG; Wiersinga, WJ, 2005) |
| "Methylmalonic acid (MMA) is a functional biomarker of vitamin B12 deficiency." | 1.38 | Highly sensitive and selective measurement of underivatized methylmalonic acid in serum and plasma by liquid chromatography-tandem mass spectrometry. ( El-Khoury, JM; Gabler, J; Spatholt, R; Wang, S; Yuan, C, 2012) |
| "Methylmalonic acid (MMA) is a metabolic intermediate transformed to succinic acid (SA) by a vitamin B(12)-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status." | 1.37 | Methylmalonic acid quantification in low serum volumes by UPLC-MS/MS. ( Allen, LH; Keyes, WR; Newman, JW; Pedersen, TL; Shahab-Ferdows, S, 2011) |
| "In the great majority of cases vitamin B12 deficiency is caused by chronic atrophic gastritis." | 1.31 | [Evaluation of analytic test methods. Stomach-intestines status is the best diagnostic method in suspected vitamin B12 deficiency]. ( Lindgren, A, 2000) |
| "Methylmalonic acid (MMA) is a dicarboxylic acid whose concentration can be increased in blood and urine in patients with an inborn error of metabolism or vitamin B(12) deficiency." | 1.31 | Analysis of dicarboxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine. ( Komaromy-Hiller, G; Kushnir, MM; Roberts, WL; Shushan, B; Urry, FM, 2001) |
| " The dosage of these two substances help to differenciate between both carencies, but it is not determinant of any of them and is an expensive method." | 1.30 | [Megaloblastic anemia: rapid and economical study]. ( Cicchetti, G; Marín, GH; Tentoni, J, 1997) |
| "Methylmalonic acid was elevated in 12." | 1.29 | Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. ( Allen, RH; Lindenbaum, J; Savage, DG; Stabler, SP, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (30.43) | 18.2507 |
| 2000's | 22 (47.83) | 29.6817 |
| 2010's | 9 (19.57) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Jarquin Campos, A | 1 |
| Risch, L | 1 |
| Nydegger, U | 1 |
| Wiesner, J | 1 |
| Vazquez Van Dyck, M | 1 |
| Renz, H | 1 |
| Stanga, Z | 1 |
| Risch, M | 1 |
| Mineva, EM | 2 |
| Sternberg, MR | 1 |
| Zhang, M | 2 |
| Aoki, Y | 1 |
| Storandt, R | 1 |
| Bailey, RL | 1 |
| Pfeiffer, CM | 2 |
| Grzybowski, A | 1 |
| Rabinowitz, DJ | 1 |
| Phinney, KW | 1 |
| Yap, AC | 1 |
| Mahamad, UA | 1 |
| Lim, SY | 1 |
| Kim, HJ | 1 |
| Choo, YM | 1 |
| Lindner, M | 1 |
| Ho, S | 1 |
| Kölker, S | 1 |
| Abdoh, G | 1 |
| Hoffmann, GF | 1 |
| Burgard, P | 1 |
| Guerra-Shinohara, EM | 1 |
| Pereira, PM | 1 |
| Kubota, AM | 1 |
| Silva, TA | 1 |
| Reis, JL | 1 |
| Miyashita, GS | 1 |
| D'Almeida, V | 1 |
| Allen, RH | 3 |
| Stabler, SP | 3 |
| Hsieh, SH | 1 |
| Cheng, PH | 1 |
| Chen, CH | 1 |
| Huang, KH | 1 |
| Chen, PH | 1 |
| Weng, YC | 1 |
| Hsieh, SL | 1 |
| Lai, F | 1 |
| Pedersen, TL | 1 |
| Keyes, WR | 1 |
| Shahab-Ferdows, S | 1 |
| Allen, LH | 1 |
| Newman, JW | 1 |
| Yuan, C | 1 |
| Gabler, J | 1 |
| El-Khoury, JM | 1 |
| Spatholt, R | 1 |
| Wang, S | 1 |
| Bauwens, M | 1 |
| De Saint-Hubert, M | 1 |
| Cleynhens, J | 1 |
| Vandeputte, C | 1 |
| Li, J | 1 |
| Devos, E | 1 |
| Hvas, AM | 3 |
| Ellegaard, J | 3 |
| Nexø, E | 3 |
| Gültepe, M | 1 |
| Ozcan, O | 1 |
| Avşar, K | 1 |
| Cetin, M | 1 |
| Ozdemir, AS | 1 |
| Gök, M | 1 |
| Kakinuma, H | 1 |
| Kobayashi, A | 1 |
| Takahashi, H | 1 |
| Vernez, L | 1 |
| Wenk, M | 1 |
| Krähenbühl, S | 1 |
| Kushnir, MM | 4 |
| Rockwood, AL | 2 |
| Nelson, GJ | 2 |
| Kwok, T | 1 |
| Cheng, G | 1 |
| Lai, WK | 1 |
| Poon, P | 1 |
| Woo, J | 1 |
| Pang, CP | 1 |
| Yue, B | 1 |
| Urry, FM | 2 |
| Hasegawa, Y | 1 |
| Iga, M | 1 |
| Kimura, M | 1 |
| Shigematsu, Y | 1 |
| Yamaguchi, S | 1 |
| Windelberg, A | 1 |
| Arseth, O | 1 |
| Kvalheim, G | 1 |
| Ueland, PM | 2 |
| Wiersinga, WJ | 1 |
| de Rooij, SE | 1 |
| Huijmans, JG | 1 |
| Fischer, C | 1 |
| Hoekstra, JB | 1 |
| Goringe, A | 1 |
| Ellis, R | 1 |
| McDowell, I | 1 |
| Vidal-Alaball, J | 1 |
| Jenkins, C | 1 |
| Butler, C | 1 |
| Worwood, M | 1 |
| Gutsche, P | 1 |
| Schmitt, H | 1 |
| Haeberlen, U | 1 |
| Ratajczyk, T | 1 |
| Szymanski, S | 1 |
| Cravens, DD | 1 |
| Nashelsky, J | 1 |
| Oh, RC | 1 |
| Blom, HJ | 1 |
| van Rooij, A | 1 |
| Hogeveen, M | 1 |
| Carlucci, F | 1 |
| Rosi, F | 1 |
| Tommassini, V | 1 |
| Tabucchi, A | 1 |
| Schneede, J | 1 |
| Savage, DG | 2 |
| Lindenbaum, J | 2 |
| Babidge, PJ | 1 |
| Babidge, WJ | 1 |
| Norman, EJ | 3 |
| Morrison, JA | 1 |
| Leeming, RJ | 1 |
| Delva, MD | 1 |
| Marín, GH | 1 |
| Tentoni, J | 1 |
| Cicchetti, G | 1 |
| Lindgren, A | 2 |
| Swolin, B | 1 |
| Nilsson, O | 1 |
| Johansson, KW | 1 |
| Kilander, AF | 1 |
| Rifai, N | 1 |
| Hagen, T | 2 |
| Bradley, L | 1 |
| Sakamoto, M | 2 |
| Korson, MS | 1 |
| Evans, JE | 1 |
| Komaromy-Hiller, G | 2 |
| Ogundipe, A | 1 |
| Shushan, B | 1 |
| Roberts, WL | 1 |
| Lous, J | 1 |
| Buchanan, DN | 1 |
| Muenzer, J | 1 |
| Thoene, JG | 1 |
| Moelby, L | 1 |
| Rasmussen, K | 1 |
| Jensen, MK | 1 |
| Pedersen, KO | 1 |
4 reviews available for methylmalonic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
[Diagnosis of vitamin B12 deficiency--time for reflection].
Topics: Biomarkers; Homocysteine; Humans; Methylmalonic Acid; Sensitivity and Specificity; Vitamin B 12; Vit | 2003 |
[Diagnosis of vitamin B12 deficiency revised].
Topics: Homocysteine; Humans; Methylmalonic Acid; Predictive Value of Tests; Schilling Test; Sensitivity and | 2005 |
Clinical inquiries. How do we evaluate a marginally low B12 level?
Topics: Evaluation Studies as Topic; Evidence-Based Medicine; Family Practice; Female; Homocysteine; Humans; | 2007 |
Vitamin B12 replacement. To B12 or not to B12?
Topics: Family Practice; Homocysteine; Humans; Methylmalonic Acid; Prevalence; Research Design; Sensitivity | 1997 |
2 trials available for methylmalonic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency.
Topics: Diagnosis; Homocysteine; Humans; Methylmalonic Acid; Sensitivity and Specificity; Transcobalamins; V | 2006 |
Increased plasma methylmalonic acid level does not predict clinical manifestations of vitamin B12 deficiency.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Denmark; Female; Follow-Up Studies; Humans; | 2001 |
40 other studies available for methylmalonic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
Diagnostic Accuracy of Holotranscobalamin, Vitamin B12, Methylmalonic Acid, and Homocysteine in Detecting B12 Deficiency in a Large, Mixed Patient Population.
Topics: Adult; Aged; Biomarkers; Cohort Studies; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Mid | 2020 |
Age-specific reference ranges are needed to interpret serum methylmalonic acid concentrations in the US population.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers; Ethnicity; Female; Humans; Kidn | 2019 |
Problems related to the diagnosis of vitamin B12 deficiency optic neuropathy.
Topics: False Positive Reactions; Homocysteine; Humans; Methylmalonic Acid; Optic Nerve Diseases; Predictive | 2014 |
An LC-MS/MS method for serum methylmalonic acid suitable for monitoring vitamin B12 status in population surveys.
Topics: Anticoagulants; Calibration; Chromatography, Liquid; Chromatography, Reverse-Phase; Gas Chromatograp | 2015 |
A coumarin-based fluorescent probe as a central nervous system disease biomarker.
Topics: Biomarkers; Biosensing Techniques; Coumarins; Fluorescent Dyes; Homocysteine; Humans; Methylmalonic | 2014 |
Newborn screening for methylmalonic acidurias--optimization by statistical parameter combination.
Topics: Amino Acid Metabolism, Inborn Errors; Humans; Infant, Newborn; Methylmalonic Acid; Neonatal Screenin | 2008 |
Increased MMA concentration and body mass index are associated with spontaneous abortion in Brazilian women: a pilot study.
Topics: Abortion, Spontaneous; Adult; Alleles; Body Mass Index; Brazil; DNA Mutational Analysis; Female; Gen | 2010 |
A multi-voting enhancement for newborn screening healthcare information system.
Topics: Algorithms; Brain Diseases, Metabolic, Inborn; Humans; Infant, Newborn; Methylmalonic Acid; Neonatal | 2010 |
Methylmalonic acid quantification in low serum volumes by UPLC-MS/MS.
Topics: Biomarkers; Chromatography, High Pressure Liquid; Cyclohexanes; Drug Stability; Female; Humans; Laur | 2011 |
Highly sensitive and selective measurement of underivatized methylmalonic acid in serum and plasma by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Female; Humans; Male; Methylmalonic Acid; Plasma; Sensitivity | 2012 |
In vitro and in vivo comparison of 18F and 123I-labeled ML10 with 68Ga-Cys2-AnxA5 for molecular imaging of apoptosis.
Topics: Animals; Annexin A5; Apoptosis; Cell Line, Tumor; Fluorine Radioisotopes; Gallium Radioisotopes; Iod | 2013 |
Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders.
Topics: Adult; Aged; Folic Acid; Homocysteine; Humans; Mental Disorders; Methylmalonic Acid; Middle Aged; Ph | 2003 |
14C-propionate incorporation assay by rapid filtration in multiwell plates.
Topics: Age of Onset; Carbon Radioisotopes; Child, Preschool; Female; Filtration; Humans; Infant; Infant, Ne | 2004 |
Determination of carnitine and acylcarnitines in plasma by high-performance liquid chromatography/electrospray ionization ion trap tandem mass spectrometry.
Topics: Calibration; Carnitine; Chromatography, High Pressure Liquid; Humans; Methylmalonic Acid; Reference | 2004 |
Simultaneous quantitative analysis of isobars by tandem mass spectrometry from unresolved chromatographic peaks.
Topics: Algorithms; Calibration; Humans; Isomerism; Mass Spectrometry; Methylmalonic Acid; Sensitivity and S | 2004 |
Use of fasting urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older persons.
Topics: Aging; Biomarkers; Creatinine; Diet, Vegetarian; Fasting; Female; Folic Acid; Hong Kong; Humans; Kid | 2004 |
Assessing analytical specificity in quantitative analysis using tandem mass spectrometry.
Topics: Cortisone; Humans; Immunosuppressive Agents; Isotopes; Mass Spectrometry; Methylmalonic Acid; Refere | 2005 |
Prenatal diagnosis for organic acid disorders using two mass spectrometric methods, gas chromatography mass spectrometry and tandem mass spectrometry.
Topics: Amniotic Fluid; Carboxylic Acids; Carnitine; Female; Fetal Diseases; Gas Chromatography-Mass Spectro | 2005 |
Automated assay for the determination of methylmalonic acid, total homocysteine, and related amino acids in human serum or plasma by means of methylchloroformate derivatization and gas chromatography-mass spectrometry.
Topics: Amino Acids; Autoanalysis; Formates; Gas Chromatography-Mass Spectrometry; Glycine; Homocysteine; Hu | 2005 |
Fingerprints of damped quantum rotation observed in solid-state proton NMR spectra.
Topics: Computer Simulation; Deuterium; Magnetic Resonance Spectroscopy; Methylmalonic Acid; Models, Chemica | 2006 |
A simple high-throughput method for the determination of plasma methylmalonic acid by liquid chromatography-tandem mass spectrometry.
Topics: Automation; Calibration; Chromatography, Liquid; Deuterium; Humans; Methods; Methylmalonic Acid; Rep | 2007 |
CE assay of methylmalonyl-coenzyme-a mutase activity.
Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Animals; Buffers; Electrophoresis, Capillary; | 2007 |
Application of capillary electrophoresis with laser-induced fluorescence detection for routine determination of methylmalonic acid in human serum.
Topics: Electrophoresis; Fluorescent Dyes; Humans; Lasers; Methylmalonic Acid; Pyrenes; Reproducibility of R | 1995 |
Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies.
Topics: Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylmalonic Acid; Predictive Value of T | 1994 |
Determination of methylmalonic acid by high-performance liquid chromatography.
Topics: Animals; Body Fluids; Cadaverine; Chemistry Techniques, Analytical; Chromatography, High Pressure Li | 1994 |
Screening elderly populations for cobalamin (vitamin B12) deficiency using the urinary methylmalonic acid assay by gas chromatography mass spectrometry.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Female; Gas Chromatography-Mass Spectrometry; Humans; | 1993 |
MMA test to detect vitamin B12 deficiency.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Sensitivity and Specificity; Vitam | 1996 |
Cobalamin and folate deficiencies.
Topics: Biomarkers; Chemistry, Clinical; Folic Acid; Folic Acid Deficiency; Hematology; Homocysteine; Humans | 1996 |
[Megaloblastic anemia: rapid and economical study].
Topics: Adolescent; Adult; Algorithms; Anemia, Megaloblastic; Cost Control; Diagnosis, Differential; Diagnos | 1997 |
Serum methylmalonic acid and total homocysteine in patients with suspected cobalamin deficiency: a clinical study based on gastrointestinal histopathological findings.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Gastric Mucosa; Homocysteine; Humans; Intestinal | 1997 |
Determination of serum physiological concentration of methylmalonic acid by gas chromatography-mass spectrometry with selected ion monitoring.
Topics: Biological Assay; Chromatography, Gas; Humans; Mass Spectrometry; Methylmalonic Acid; Sensitivity an | 1998 |
A GC/MS/MS screening method for multiple organic acidemias from urine specimens.
Topics: Acids; Adipates; Automation; Biomarkers; Caprylates; Decanoic Acids; Dicarboxylic Acids; Fumarates; | 1999 |
Urinary methylmalonic acid/creatinine ratio: a gold standard test for tissue vitamin B12 deficiency.
Topics: Aged; Creatinine; Humans; Methylmalonic Acid; Sensitivity and Specificity; Veterans; Vitamin B 12; V | 1999 |
Optimization and performance of a rapid gas chromatography-mass spectrometry analysis for methylmalonic acid determination in serum and plasma.
Topics: Adult; Aged; Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Middle Aged; Reproduc | 2000 |
Etiology and diagnostic evaluation of macrocytosis.
Topics: Adult; Aged; Alcohol Drinking; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow Diseases; Diag | 2000 |
[Evaluation of analytic test methods. Stomach-intestines status is the best diagnostic method in suspected vitamin B12 deficiency].
Topics: Biomarkers; Gastric Mucosa; Gastritis, Atrophic; Gastrointestinal Diseases; Gastroscopy; Homocystein | 2000 |
Analysis of dicarboxylic acids by tandem mass spectrometry. High-throughput quantitative measurement of methylmalonic acid in serum, plasma, and urine.
Topics: Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Plasma; Se | 2001 |
Use of plasma methylmalonic acid in diagnosing vitamin B-12 deficiency in general practice.
Topics: Adult; Aged; Aged, 80 and over; Creatinine; Erythrocyte Indices; Erythrocytes; Family Practice; Fema | 2002 |
Positive-ion thermospray liquid chromatography-mass spectrometry: detection of organic acidurias.
Topics: Argininosuccinic Acid; Carboxylic Acids; Chromatography, Thin Layer; Female; Humans; Infant; Infant, | 1990 |
The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methylmalonic Acid; Middle Aged; Prospective S | 1990 |