methylmalonic acid has been researched along with Seizures in 16 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 7.74 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "Methylene blue (MB) is a thiazine dye with cationic and lipophilic properties that acts as an electron transfer mediator in the mitochondria." | 5.34 | Methylene blue prevents methylmalonate-induced seizures and oxidative damage in rat striatum. ( Coelho, RC; de Carvalho Myskiw, J; Ferreira, AP; Fighera, MR; Fiorenza, NG; Furian, AF; Mello, CF; Oliveira, MS; Petry, JC; Royes, LF, 2007) |
| "Hyperammonemia is a common finding in children with methylmalonic acidemia." | 3.83 | A neuronal disruption in redox homeostasis elicited by ammonia alters the glycine/glutamate (GABA) cycle and contributes to MMA-induced excitability. ( Braga, DV; da Silva, AM; da Silva, LR; da Silveira Junior, ME; de Oliveira Ferreira, AP; Della-Pace, ID; Dobrachinski, F; Fighera, MR; Furian, AF; Gabbi, P; Grisólia, AB; Marchesan, S; Oliveira, MS; Ribeiro, LR; Rodrigues, FS; Royes, LF; Soares, FA, 2016) |
| "Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurological dysfunction, including seizures." | 3.79 | Fish oil attenuates methylmalonate-induced seizures. ( Banderó, CR; Cysneiros, RM; Dal Ri, NM; Emanuelli, T; Furian, AF; Gomes, AT; Mello, CF; Oliveira, MS; Rambo, LM; Salvadori, MG; Scorza, FA, 2013) |
| "Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurologic dysfunction, including seizures." | 3.78 | Prostaglandin E(2) potentiates methylmalonate-induced seizures. ( Banderó, CR; Bortoluzzi, VT; Bueno, LM; Gomes, AT; Jesse, AC; Mello, CF; Oliveira, MS; Rambo, LM; Salvadori, MG, 2012) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 3.74 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "Methylene blue (MB) is a thiazine dye with cationic and lipophilic properties that acts as an electron transfer mediator in the mitochondria." | 1.34 | Methylene blue prevents methylmalonate-induced seizures and oxidative damage in rat striatum. ( Coelho, RC; de Carvalho Myskiw, J; Ferreira, AP; Fighera, MR; Fiorenza, NG; Furian, AF; Mello, CF; Oliveira, MS; Petry, JC; Royes, LF, 2007) |
| "GM1 pretreatment decreased MMA-induced convulsions (GM1-MMA: 6." | 1.32 | GM1 ganglioside attenuates convulsions and thiobarbituric acid reactive substances production induced by the intrastriatal injection of methylmalonic acid. ( Bonini, JS; de Oliveira, TG; Dutra-Filho, CS; Fighera, MR; Frussa-Filho, R; Mello, CF; Rocha, JB; Rubin, MA, 2003) |
| "Predominant clinical features include microcephaly, hydrocephalus, seizures, and white-matter changes on magnetic resonance imaging in early-onset cases." | 1.31 | Practical management of combined methylmalonicaciduria and homocystinuria. ( Bodamer, OA; Smith, DL, 2002) |
| "Mental retardation was identified in most of the cases." | 1.31 | Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases. ( Biancheri, R; Caruso, U; Cerone, R; Gatti, R; Perrone, MV; Rossi, A; Schiaffino, MC; Veneselli, E, 2001) |
| "Rotational behavior and convulsions were prevented by intrastriatal preadministration of MK-801 and attenuated by preadministration of succinate." | 1.29 | Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms. ( Begnini, J; da Costa, E; de Bastiani, J; de Mello, CF; Jiménez-Bernal, RE; Rubin, MA; Wajner, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Royes, LF | 7 |
| Gabbi, P | 1 |
| Ribeiro, LR | 2 |
| Della-Pace, ID | 1 |
| Rodrigues, FS | 1 |
| de Oliveira Ferreira, AP | 1 |
| da Silveira Junior, ME | 1 |
| da Silva, LR | 1 |
| Grisólia, AB | 1 |
| Braga, DV | 1 |
| Dobrachinski, F | 1 |
| da Silva, AM | 1 |
| Soares, FA | 1 |
| Marchesan, S | 1 |
| Furian, AF | 7 |
| Oliveira, MS | 8 |
| Fighera, MR | 8 |
| Rambo, LM | 3 |
| Ferreira, AP | 2 |
| Saraiva, AL | 1 |
| Souza, MA | 1 |
| Lima, FD | 1 |
| Magni, DV | 1 |
| Dezengrini, R | 1 |
| Flores, EF | 1 |
| Butterfield, DA | 1 |
| Ferreira, J | 1 |
| dos Santos, AR | 1 |
| Mello, CF | 11 |
| Salvadori, MG | 2 |
| Banderó, CR | 2 |
| Jesse, AC | 1 |
| Gomes, AT | 2 |
| Bueno, LM | 1 |
| Bortoluzzi, VT | 1 |
| Dal Ri, NM | 1 |
| Scorza, FA | 1 |
| Cysneiros, RM | 1 |
| Emanuelli, T | 1 |
| Smith, DL | 1 |
| Bodamer, OA | 1 |
| Bonini, JS | 2 |
| de Oliveira, TG | 1 |
| Frussa-Filho, R | 2 |
| Rocha, JB | 1 |
| Dutra-Filho, CS | 2 |
| Rubin, MA | 3 |
| da Silva, LG | 1 |
| Malfatti, CR | 3 |
| Schneider, PH | 1 |
| Braga, AL | 1 |
| Wajner, M | 2 |
| Francescato, L | 1 |
| Sanabria, ER | 1 |
| Cavalheiro, EA | 1 |
| Marisco, Pda C | 1 |
| Ribeiro, MC | 1 |
| Lima, TT | 1 |
| Mann, KC | 1 |
| Brenner, GM | 1 |
| Fiorenza, NG | 3 |
| de Carvalho Myskiw, J | 2 |
| Boxer, AL | 1 |
| Kramer, JH | 1 |
| Johnston, K | 1 |
| Goldman, J | 1 |
| Finley, R | 1 |
| Miller, BL | 1 |
| Petry, JC | 2 |
| Coelho, RC | 2 |
| Perry, ML | 1 |
| Schweigert, ID | 1 |
| Muller, AP | 1 |
| Paquetti, L | 1 |
| Rigo, FK | 1 |
| Garrido-Sanabria, ER | 1 |
| de Mello, CF | 1 |
| Begnini, J | 1 |
| Jiménez-Bernal, RE | 1 |
| de Bastiani, J | 1 |
| da Costa, E | 1 |
| Biancheri, R | 1 |
| Cerone, R | 1 |
| Schiaffino, MC | 1 |
| Caruso, U | 1 |
| Veneselli, E | 1 |
| Perrone, MV | 1 |
| Rossi, A | 1 |
| Gatti, R | 1 |
16 other studies available for methylmalonic acid and Seizures
| Article | Year |
|---|---|
A neuronal disruption in redox homeostasis elicited by ammonia alters the glycine/glutamate (GABA) cycle and contributes to MMA-induced excitability.
Topics: Ammonia; Animals; Cerebral Cortex; Cytokines; Electroencephalography; Glutamic Acid; Glycine; Homeos | 2016 |
Methylmalonate-induced seizures are attenuated in inducible nitric oxide synthase knockout mice.
Topics: Animals; Brain; Brain Mapping; Electroencephalography; Female; Male; Methylmalonic Acid; Mice; Mice, | 2009 |
Prostaglandin E(2) potentiates methylmalonate-induced seizures.
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Electrodes, I | 2012 |
Fish oil attenuates methylmalonate-induced seizures.
Topics: Animals; Anticonvulsants; Electroencephalography; Fish Oils; Male; Methylmalonic Acid; Random Alloca | 2013 |
Practical management of combined methylmalonicaciduria and homocystinuria.
Topics: Adolescent; Adult; Betaine; Carnitine; Child; Child, Preschool; Female; Folic Acid; Gastrointestinal | 2002 |
GM1 ganglioside attenuates convulsions and thiobarbituric acid reactive substances production induced by the intrastriatal injection of methylmalonic acid.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Corpus Striatum; G(M1) Ganglioside; Lipid Peroxidation; Mal | 2003 |
Creatine protects against the convulsive behavior and lactate production elicited by the intrastriatal injection of methylmalonate.
Topics: Animals; Behavior, Animal; Corpus Striatum; Creatine; Disease Models, Animal; Dizocilpine Maleate; D | 2003 |
Intrastriatal methylmalonic acid administration induces convulsions and TBARS production, and alters Na+,K+-ATPase activity in the rat striatum and cerebral cortex.
Topics: Animals; Basal Ganglia; Cerebral Cortex; Electrodes, Implanted; Electroencephalography; Lipid Peroxi | 2003 |
Ammonia potentiates methylmalonic acid-induced convulsions and TBARS production.
Topics: Acetates; Ammonia; Ammonium Chloride; Animals; Behavior, Animal; Corpus Striatum; Drug Synergism; En | 2003 |
Involvement of NO in the convulsive behavior and oxidative damage induced by the intrastriatal injection of methylmalonate.
Topics: Animals; Enzyme Inhibitors; Injections, Intraventricular; Male; Methylmalonic Acid; NG-Nitroarginine | 2005 |
Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment.
Topics: Adult; Anticoagulants; Betaine; Cognition Disorders; Confusion; Disease Progression; Drug Therapy, C | 2005 |
Methylene blue prevents methylmalonate-induced seizures and oxidative damage in rat striatum.
Topics: Animals; Corpus Striatum; Electroencephalography; Male; Methylene Blue; Methylmalonic Acid; Oxidativ | 2007 |
The role of nitric oxide on the convulsive behavior and oxidative stress induced by methylmalonate: an electroencephalographic and neurochemical study.
Topics: Animals; Anticonvulsants; Arginine; Corpus Striatum; Dose-Response Relationship, Drug; Electroenceph | 2007 |
Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients?
Topics: Analysis of Variance; Animals; Baclofen; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relati | 2007 |
Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Indicators and Reage | 1996 |
Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Atrophy; Brain; Brain Diseases, Metabolic | 2001 |