methylmalonic acid has been researched along with Pregnancy in 118 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite participation in overlapping metabolic pathways, the relationship between choline and vitamin B-12 has not been well characterized especially during pregnancy." | 9.30 | Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy. ( Bae, S; Caudill, MA; Jiang, X; King, JH; Klatt, KC; Kwan, STC; Malysheva, OV; Roberson, MS; Yan, J, 2019) |
| "Combined methylmalonic acidemia and homocystinuria, cblC type, is an inborn error of intracellular cobalamin metabolism with a wide spectrum of clinical manifestations that is stated to be the most common inherited disorder of cobalamin metabolism." | 8.88 | Combined methylmalonic acidemia and homocystinuria, cblC type. I. Clinical presentations, diagnosis and management. ( Carrillo-Carrasco, N; Chandler, RJ; Venditti, CP, 2012) |
| "Fasting plasma total homocysteine (tHcy) during pregnancy and low cobalamin status during early pregnancy are associated with mid-childhood metabolic score and its components in the offspring." | 8.31 | Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring. ( Ballesteros, M; Cavallé-Busquets, P; Fernandez-Ballart, J; Grifoll, C; Masana, L; Murphy, MM; Ornosa-Martin, G; Ramos-Rodriguez, C; Rojas-Gómez, A; Solé-Navais, P; Ueland, PM, 2023) |
| "Combined methylmalonic acidemia and homocystinuria, cobalamin C type (cblC defect) is the most common inborn error of cobalamin metabolism, and different approaches have been applied to its prenatal diagnosis." | 8.02 | Value of amniotic fluid homocysteine assay in prenatal diagnosis of combined methylmalonic acidemia and homocystinuria, cobalamin C type. ( Chen, T; Gong, Z; Gu, X; Han, L; Liang, L; Qiu, W; Wang, L; Xiao, B; Xu, F; Ye, J; Zhang, H; Zhu, H, 2021) |
| "Plasma levels of folate, cobalamin, pyridoxal 5'-phosphate (vitamin B6), riboflavin, and the metabolic markers total homocysteine, methylmalonic acid and 3-hydro-xykynurenine were measured in pregnancy week 18 and related to reported intake of folic acid from 4 weeks prior to conception throughout week 18 in 2911 women from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health." | 7.79 | Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements. ( Bjørke-Monsen, AL; Magnus, P; Midttun, Ø; Nilsen, RM; Reichborn-Kjennerud, T; Roth, C; Stoltenberg, C; Susser, E; Ueland, PM; Vollset, SE, 2013) |
| "Hyperhomocysteinemia is a risk factor in obstetrical complications such as pre-eclampsia, 'hemolysis, elevated liver enzymes, low platelet' (HELLP)-syndrome and placental insufficiency." | 7.72 | Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency. ( Geisel, J; Herrmann, W; Hübner, U; Koch, I; Obeid, R; Retzke, U, 2004) |
| "We report on a favourable pregnancy in a woman affected by mut- methylmalonic acidaemia." | 7.71 | Successful pregnancy in a woman with mut- methylmalonic acidaemia. ( Baiocco, F; Boenzi, S; Deodato, F; Dionisi-Vici, C; Rizzo, C; Sabetta, G, 2002) |
| "Prenatal diagnosis for combined methylmalonic aciduria and homocystinuria was performed in five at-risk pregnancies by determination of methylmalonic acid (MMA) and total homocysteine (Hcy) in amniotic fluid supernatant." | 7.70 | Reliability of biochemical parameters used in prenatal diagnosis of combined methylmalonic aciduria and homocystinuria. ( Chadefaux-Vekemans, B; Garcia, MJ; Jakobs, C; Kamoun, P; Merinero, B; Pérez-Cerdá, C; Tonetti, C; Ugarte, M; Zittoun, J, 1998) |
| "Methylmalonic acidaemia is an inborn error of metabolism characterized by recurrent episodes of life-threatening ketoacidosis." | 7.70 | Successful pregnancy in severe methylmalonic acidaemia. ( Desnick, RJ; Eddleman, K; Gaddipati, S; Sansaricq, C; Snyderman, SE; Wasserstein, MP, 1999) |
| "The role of folic acid in the primary prevention of neural tube defects (NTDs) is well established." | 7.69 | Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects. ( Adams, MJ; Cheek, JE; Haddow, JE; Henry, JP; Khoury, MJ; Knight, GJ; Scanlon, KS; Stabler, SP; Stevenson, RE; Sylvester, GC, 1995) |
| "In a pregnant woman, who had given birth to a child with methylmalonic acidaemia previously, urinary methylmalonate was measured at various intervals in the second half of the pregnancy." | 7.66 | Methylmalonate excretion in a pregnancy at risk for methylmalonic acidaemia. ( Bakker, HD; Duran, M; van Gennip, AH; Wadman, SK, 1978) |
| "Methylmalonic aciduria is treated with a natural protein-restricted diet with adequate energy intake to sustain metabolic balance." | 5.62 | Dietary Treatment from Birth to Pregnancy in a Woman with Methylmalonic Aciduria. ( Kowalik, A; MacDonald, A; Sykut-Cegielska, J, 2021) |
| "Methylmalonic Acidurias (MMAs) are a group of inborn errors of metabolism (IEMs), specifically of propionate catabolism characterized by gastrointestinal and neurometabolic manifestations resulting from a deficiency in the function of methylmalonyl-CoA mutase, methylmalonyl-CoA epimerase, and cobalamin metabolism." | 5.56 | A False-Positive Case of Methylmalonic Aciduria by Tandem Mass Spectrometry Newborn Screening Dependent on Maternal Malnutrition in Pregnancy. ( Brindisino, P; Cicalini, I; Consalvo, A; De Laurenzi, V; Dionisi-Vici, C; Gasparroni, G; Gazzolo, D; Pieragostino, D; Rizzo, C; Rossi, C; Semeraro, D; Valentinuzzi, S; Zucchelli, M, 2020) |
| "Presently pregnancy is no more exceptional in women with metabolic diseases." | 5.39 | Pregnancy in a methylmalonic acidemia patient with kidney transplantation: a case report. ( Bellelli, E; Carducci, C; Elli, M; Gentile, I; Labriola, D; Lubrano, R; Paoli, S; Pérez, B; Santagata, S; Ugarte, M, 2013) |
| "Despite participation in overlapping metabolic pathways, the relationship between choline and vitamin B-12 has not been well characterized especially during pregnancy." | 5.30 | Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy. ( Bae, S; Caudill, MA; Jiang, X; King, JH; Klatt, KC; Kwan, STC; Malysheva, OV; Roberson, MS; Yan, J, 2019) |
| "Methylmalonic aciduria is a rare metabolic disorder of amino acid metabolism that is characterized by accumulation of large amounts of methylmalonic acid in the blood and urine." | 5.29 | Methylmalonic aciduria in pregnancy: a case report. ( Diss, E; Iams, J; Reed, N; Roe, C; Roe, DS, 1995) |
| "Combined methylmalonic acidemia and homocystinuria, cblC type, is an inborn error of intracellular cobalamin metabolism with a wide spectrum of clinical manifestations that is stated to be the most common inherited disorder of cobalamin metabolism." | 4.88 | Combined methylmalonic acidemia and homocystinuria, cblC type. I. Clinical presentations, diagnosis and management. ( Carrillo-Carrasco, N; Chandler, RJ; Venditti, CP, 2012) |
| "Although early epidemiologic studies showed a protective effect of adequate maternal folic acid (FA) status against neural tube defects (NTDs), the role of adequate vitamin B-12 nutrition in the putative reduction of NTD frequency has remained uncertain." | 4.85 | Vitamin B-12 and neural tube defects: the Canadian experience. ( Cole, DE; Ray, JG; Thompson, MD, 2009) |
| "Fasting plasma total homocysteine (tHcy) during pregnancy and low cobalamin status during early pregnancy are associated with mid-childhood metabolic score and its components in the offspring." | 4.31 | Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring. ( Ballesteros, M; Cavallé-Busquets, P; Fernandez-Ballart, J; Grifoll, C; Masana, L; Murphy, MM; Ornosa-Martin, G; Ramos-Rodriguez, C; Rojas-Gómez, A; Solé-Navais, P; Ueland, PM, 2023) |
| "Combined methylmalonic acidemia and homocystinuria, cobalamin C type (cblC defect) is the most common inborn error of cobalamin metabolism, and different approaches have been applied to its prenatal diagnosis." | 4.02 | Value of amniotic fluid homocysteine assay in prenatal diagnosis of combined methylmalonic acidemia and homocystinuria, cobalamin C type. ( Chen, T; Gong, Z; Gu, X; Han, L; Liang, L; Qiu, W; Wang, L; Xiao, B; Xu, F; Ye, J; Zhang, H; Zhu, H, 2021) |
| "In the longitudinal Reus-Tarragona Birth Cohort study from <12 gestational weeks throughout pregnancy, fasting plasma and red blood cell (RBC) folate, plasma cobalamin, holotranscobalamin (holoTC), methylmalonic acid (MMA), total homocysteine (tHcy), hemoglobin, mean cell volume (MCV), postglucose-load serum glucose, gestational hypertension, gestational age at birth, and birth weight were recorded in 563 participants." | 3.88 | Early pregnancy folate-cobalamin interactions and their effects on cobalamin status and hematologic variables throughout pregnancy. ( Ballesteros, M; Cavallé-Busquets, P; Colomina, JM; Fernandez-Ballart, J; Inglès-Puig, M; Murphy, MM; Ornosa-Martín, G; Salat-Batlle, J; Solé-Navais, P; Ueland, PM, 2018) |
| "This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes." | 3.83 | A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women. ( Cho, YY; Choi, R; Choi, S; Chung, JH; Kim, HJ; Kim, SW; Lee, SY; Lim, Y; Oh, SY, 2016) |
| "Plasma levels of folate, cobalamin, pyridoxal 5'-phosphate (vitamin B6), riboflavin, and the metabolic markers total homocysteine, methylmalonic acid and 3-hydro-xykynurenine were measured in pregnancy week 18 and related to reported intake of folic acid from 4 weeks prior to conception throughout week 18 in 2911 women from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health." | 3.79 | Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements. ( Bjørke-Monsen, AL; Magnus, P; Midttun, Ø; Nilsen, RM; Reichborn-Kjennerud, T; Roth, C; Stoltenberg, C; Susser, E; Ueland, PM; Vollset, SE, 2013) |
| "Hyperhomocysteinemia is a risk factor in obstetrical complications such as pre-eclampsia, 'hemolysis, elevated liver enzymes, low platelet' (HELLP)-syndrome and placental insufficiency." | 3.72 | Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency. ( Geisel, J; Herrmann, W; Hübner, U; Koch, I; Obeid, R; Retzke, U, 2004) |
| "We report on a favourable pregnancy in a woman affected by mut- methylmalonic acidaemia." | 3.71 | Successful pregnancy in a woman with mut- methylmalonic acidaemia. ( Baiocco, F; Boenzi, S; Deodato, F; Dionisi-Vici, C; Rizzo, C; Sabetta, G, 2002) |
| "Prenatal diagnosis for combined methylmalonic aciduria and homocystinuria was performed in five at-risk pregnancies by determination of methylmalonic acid (MMA) and total homocysteine (Hcy) in amniotic fluid supernatant." | 3.70 | Reliability of biochemical parameters used in prenatal diagnosis of combined methylmalonic aciduria and homocystinuria. ( Chadefaux-Vekemans, B; Garcia, MJ; Jakobs, C; Kamoun, P; Merinero, B; Pérez-Cerdá, C; Tonetti, C; Ugarte, M; Zittoun, J, 1998) |
| "Methylmalonic acidaemia is an inborn error of metabolism characterized by recurrent episodes of life-threatening ketoacidosis." | 3.70 | Successful pregnancy in severe methylmalonic acidaemia. ( Desnick, RJ; Eddleman, K; Gaddipati, S; Sansaricq, C; Snyderman, SE; Wasserstein, MP, 1999) |
| "To determine the significance of the commonly observed fall in serum vitamin B12 levels during pregnancy, serum levels of the B12 metabolites methylmalonic acid (MMA) and homocysteine (Hcy) were measured in a group of 50 pregnant patients with subnormal serum B12 (range 45-199 pg/ml) and the results compared with those of 25 pregnant controls (serum B12(208-580) pg/ml)." | 3.69 | Biochemical indices of vitamin B12 nutrition in pregnant patients with subnormal serum vitamin B12 levels. ( Bennett, M; Bottiglieri, T; Hyland, K; McGrath, K; Metz, J, 1995) |
| "The role of folic acid in the primary prevention of neural tube defects (NTDs) is well established." | 3.69 | Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects. ( Adams, MJ; Cheek, JE; Haddow, JE; Henry, JP; Khoury, MJ; Knight, GJ; Scanlon, KS; Stabler, SP; Stevenson, RE; Sylvester, GC, 1995) |
| " We considered whether homocysteine metabolism via the enzyme methionine synthase, which requires both folate and B12, could be the critical defect in folate-related neural tube defects." | 3.69 | Homocysteine metabolism in pregnancies complicated by neural-tube defects. ( Conley, MR; Kirke, PN; Lee, YJ; McPartlin, JM; Mills, JL; Scott, JM; Weir, DG, 1995) |
| " Two groups of ewes were fed on a cobalt-deficient diet throughout pregnancy; one group (group A) was given the diet from the beginning of pregnancy, whilst the other (group B) received the diet for 16 weeks before mating." | 3.66 | Effects of cobalt deficiency in pregnant and post-parturient ewes and their lambs. ( Duncan, WR; Garton, GA; Morrison, ER, 1981) |
| "In a pregnant woman, who had given birth to a child with methylmalonic acidaemia previously, urinary methylmalonate was measured at various intervals in the second half of the pregnancy." | 3.66 | Methylmalonate excretion in a pregnancy at risk for methylmalonic acidaemia. ( Bakker, HD; Duran, M; van Gennip, AH; Wadman, SK, 1978) |
| "Women were immunized with pandemic influenza A (H1N1) vaccine at 26- to 28-week gestation." | 2.82 | Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh. ( Ahmad, SM; Ahmed, T; Ahsan, KB; Allen, LH; Hampel, D; Rahman, SM; Raqib, R; Rashid, M; Roy, A; Shahab-Ferdows, S; Siddiqua, TJ, 2016) |
| "Vitamin B12 deficiency is common in certain populations, such as in India, where there is also a rising prevalence of Type 2 diabetes, obesity and their complications." | 2.50 | The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity. ( Finer, S; Hitman, G; Saravanan, P; Yajnik, C, 2014) |
| "A total of 63." | 1.62 | Maternal vitamin B12 deficiency and perinatal outcomes in southern India. ( Dwarkanath, P; Finkelstein, JL; Fothergill, A; Krisher, JT; Kurpad, AV; Thomas, T, 2021) |
| "Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression." | 1.62 | Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women. ( Bharadwaj, B; Dhiman, P; Pillai, RR; Premkumar, N; Rajendiran, S; Ranjan, VP; Wilson, AB, 2021) |
| "Methylmalonic aciduria is treated with a natural protein-restricted diet with adequate energy intake to sustain metabolic balance." | 1.62 | Dietary Treatment from Birth to Pregnancy in a Woman with Methylmalonic Aciduria. ( Kowalik, A; MacDonald, A; Sykut-Cegielska, J, 2021) |
| "Methylmalonic Acidurias (MMAs) are a group of inborn errors of metabolism (IEMs), specifically of propionate catabolism characterized by gastrointestinal and neurometabolic manifestations resulting from a deficiency in the function of methylmalonyl-CoA mutase, methylmalonyl-CoA epimerase, and cobalamin metabolism." | 1.56 | A False-Positive Case of Methylmalonic Aciduria by Tandem Mass Spectrometry Newborn Screening Dependent on Maternal Malnutrition in Pregnancy. ( Brindisino, P; Cicalini, I; Consalvo, A; De Laurenzi, V; Dionisi-Vici, C; Gasparroni, G; Gazzolo, D; Pieragostino, D; Rizzo, C; Rossi, C; Semeraro, D; Valentinuzzi, S; Zucchelli, M, 2020) |
| "Methylmalonic acid (MMA) is a sensitive indicator of B12 status." | 1.46 | South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women. ( Green, TJ; Isman, C; Jeruszka-Bielak, M; Lamers, Y; Li, W; Schroder, TH, 2017) |
| "Methylmalonic acid (MMA) is a by-product of propionic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl CoA mutase." | 1.43 | A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin. ( Abaan, HO; Bailey-Wilson, JE; Brody, LC; Casey, M; Cropp, CD; Cunningham, C; Kim, Y; McGaughey, DM; McNulty, H; Mills, JL; Molloy, AM; O'Neill, MB; Pangilinan, F; Shane, B; Strain, JJ; Ueland, PM; Velkova, A; Ward, M; Wilson, AF, 2016) |
| "Presently pregnancy is no more exceptional in women with metabolic diseases." | 1.39 | Pregnancy in a methylmalonic acidemia patient with kidney transplantation: a case report. ( Bellelli, E; Carducci, C; Elli, M; Gentile, I; Labriola, D; Lubrano, R; Paoli, S; Pérez, B; Santagata, S; Ugarte, M, 2013) |
| "Methylmalonic aciduria is an inborn error of metabolism characterized by accumulation of methylmalonate (MMA), propionate and 2-methylcitrate (2-MCA) in body fluids." | 1.39 | Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures. ( Ballhausen, D; Bonafé, L; Braissant, O; Henry, H; Jafari, P; Zavadakova, P, 2013) |
| "Methylmalonic aciduria is a common inherited metabolic disorder." | 1.37 | Prenatal diagnosis of methylmalonic aciduria by measuring methylmalonic acid in dried amniotic fluid on filter paper using gas chromatography-mass spectrometry. ( Inoue, Y; Ohse, M, 2011) |
| "The occurrence of non-mosaic double trisomy is exceptional in newborns." | 1.35 | Double aneuploidy (48,XXY,+21) of maternal origin in a child born to a 13-year-old mother: evaluation of the maternal folate metabolism. ( Alves da Silva, AF; Biselli, JM; Carvalho, VM; Eberlin, MN; Goloni-Bertollo, EM; Haddad, R; Machado, FB; Medina-Acosta, E; Pavarino-Bertelli, EC; Vannucchi, H; Zampieri, BL, 2009) |
| "Thereby, the underlying pernicious anemia was masked." | 1.35 | [Thromboembolic events, abortions and a sick infant--unusual presentation of a vitamin deficiency]. ( Driever, PH; Hennermann, JB; Massenkeil, G; Sturm, I; von Arnim-Baas, A, 2008) |
| " The pathomechanisms involved are still unknown, a contribution of toxic organic acids, in particular MMA, has been suggested." | 1.31 | Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity. ( Farkas, LM; Feyh, P; Hinz, A; Hoffmann, GF; Hörster, F; Kölker, S; Mayatepek, E; Okun, JG; Sauer, S; Unsicker, K, 2002) |
| " The dosage of these two substances help to differenciate between both carencies, but it is not determinant of any of them and is an expensive method." | 1.30 | [Megaloblastic anemia: rapid and economical study]. ( Cicchetti, G; Marín, GH; Tentoni, J, 1997) |
| "Methylmalonic aciduria is a rare metabolic disorder of amino acid metabolism that is characterized by accumulation of large amounts of methylmalonic acid in the blood and urine." | 1.29 | Methylmalonic aciduria in pregnancy: a case report. ( Diss, E; Iams, J; Reed, N; Roe, C; Roe, DS, 1995) |
| "Methylmalonic acid was measured in cattle urine by decarboxylating it to propionate with sulfuric acid and heat and quantifying the propionate so formed by gas-liquid chromatography." | 1.26 | A technique for measurement of methylmalonic acid in cattle urine. ( Barton, EP; Elliot, JM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (23.73) | 18.7374 |
| 1990's | 19 (16.10) | 18.2507 |
| 2000's | 32 (27.12) | 29.6817 |
| 2010's | 27 (22.88) | 24.3611 |
| 2020's | 12 (10.17) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 3 |
| Chen, Z | 1 |
| Kang, L | 1 |
| He, R | 1 |
| Song, J | 1 |
| Shi, C | 1 |
| Chen, J | 1 |
| Dong, H | 2 |
| Zhang, Y | 3 |
| Ma, Y | 1 |
| Wu, T | 1 |
| Wang, Q | 2 |
| Ding, Y | 2 |
| Li, X | 1 |
| Li, D | 1 |
| Li, M | 1 |
| Jin, Y | 2 |
| Qin, J | 3 |
| Yang, Y | 1 |
| Rojas-Gómez, A | 1 |
| Solé-Navais, P | 2 |
| Cavallé-Busquets, P | 2 |
| Ornosa-Martin, G | 2 |
| Grifoll, C | 1 |
| Ramos-Rodriguez, C | 1 |
| Fernandez-Ballart, J | 2 |
| Masana, L | 1 |
| Ballesteros, M | 2 |
| Ueland, PM | 9 |
| Murphy, MM | 3 |
| Lipari Pinto, P | 1 |
| Florindo, C | 1 |
| Janeiro, P | 1 |
| Santos, RL | 1 |
| Mexia, S | 1 |
| Rocha, H | 1 |
| Tavares de Almeida, I | 1 |
| Vilarinho, L | 1 |
| Gaspar, A | 1 |
| Delgado, JA | 1 |
| Pastor García, MI | 1 |
| Márquez Jiménez, N | 1 |
| Costa Petit, G | 1 |
| Regís Perelló, A | 1 |
| Robles, J | 1 |
| Bauça, JM | 1 |
| King, JH | 1 |
| Kwan, STC | 1 |
| Bae, S | 2 |
| Klatt, KC | 1 |
| Yan, J | 2 |
| Malysheva, OV | 1 |
| Jiang, X | 2 |
| Roberson, MS | 1 |
| Caudill, MA | 2 |
| Rossi, C | 1 |
| Cicalini, I | 1 |
| Rizzo, C | 2 |
| Zucchelli, M | 1 |
| Consalvo, A | 1 |
| Valentinuzzi, S | 1 |
| Semeraro, D | 1 |
| Gasparroni, G | 1 |
| Brindisino, P | 1 |
| Gazzolo, D | 1 |
| Dionisi-Vici, C | 3 |
| De Laurenzi, V | 1 |
| Pieragostino, D | 1 |
| Kowalik, A | 1 |
| MacDonald, A | 1 |
| Sykut-Cegielska, J | 1 |
| Dhiman, P | 1 |
| Pillai, RR | 1 |
| Wilson, AB | 1 |
| Premkumar, N | 1 |
| Bharadwaj, B | 1 |
| Ranjan, VP | 1 |
| Rajendiran, S | 1 |
| Gabriel, MC | 1 |
| Rice, SM | 1 |
| Sloan, JL | 1 |
| Mossayebi, MH | 1 |
| Venditti, CP | 2 |
| Al-Kouatly, HB | 1 |
| Chen, T | 1 |
| Liang, L | 1 |
| Zhang, H | 1 |
| Ye, J | 1 |
| Qiu, W | 1 |
| Xiao, B | 1 |
| Zhu, H | 1 |
| Wang, L | 1 |
| Xu, F | 1 |
| Gong, Z | 1 |
| Gu, X | 1 |
| Han, L | 1 |
| Finkelstein, JL | 1 |
| Fothergill, A | 1 |
| Krisher, JT | 1 |
| Thomas, T | 2 |
| Kurpad, AV | 2 |
| Dwarkanath, P | 1 |
| Zharmakhanova, G | 1 |
| Syrlybayeva, L | 1 |
| Kononets, V | 1 |
| Nurbaulina, E | 1 |
| Baikadamova, L | 1 |
| Schwinger, C | 1 |
| Sharma, S | 1 |
| Chandyo, RK | 1 |
| Hysing, M | 1 |
| Kvestad, I | 1 |
| Ulak, M | 1 |
| Ranjitkar, S | 1 |
| Shrestha, M | 1 |
| Shrestha, LP | 1 |
| McCann, A | 1 |
| Strand, TA | 1 |
| Jeruszka-Bielak, M | 1 |
| Isman, C | 1 |
| Schroder, TH | 3 |
| Li, W | 1 |
| Green, TJ | 1 |
| Lamers, Y | 3 |
| Salat-Batlle, J | 1 |
| Inglès-Puig, M | 1 |
| Colomina, JM | 1 |
| Liu, YP | 1 |
| Song, JQ | 2 |
| Zheng, H | 1 |
| Ma, YY | 1 |
| Wu, TF | 1 |
| Li, XY | 1 |
| Li, DX | 1 |
| Li, MQ | 1 |
| Wang, ZX | 1 |
| Yuan, Y | 1 |
| Li, HX | 1 |
| Yang, YL | 2 |
| Huemer, M | 1 |
| Diodato, D | 1 |
| Martinelli, D | 1 |
| Olivieri, G | 1 |
| Blom, H | 1 |
| Gleich, F | 1 |
| Kölker, S | 2 |
| Kožich, V | 1 |
| Morris, AA | 1 |
| Seifert, B | 1 |
| Froese, DS | 1 |
| Baumgartner, MR | 1 |
| Martin, CA | 1 |
| Baethmann, M | 1 |
| Ballhausen, D | 2 |
| Blasco-Alonso, J | 1 |
| Boy, N | 1 |
| Bueno, M | 1 |
| Burgos Peláez, R | 1 |
| Cerone, R | 1 |
| Chabrol, B | 1 |
| Chapman, KA | 1 |
| Couce, ML | 1 |
| Crushell, E | 1 |
| Dalmau Serra, J | 1 |
| Diogo, L | 1 |
| Ficicioglu, C | 2 |
| García Jimenez, MC | 1 |
| García Silva, MT | 1 |
| Gaspar, AM | 1 |
| Gautschi, M | 1 |
| González-Lamuño, D | 1 |
| Gouveia, S | 1 |
| Grünewald, S | 1 |
| Hendriksz, C | 2 |
| Janssen, MCH | 1 |
| Jesina, P | 1 |
| Koch, J | 1 |
| Konstantopoulou, V | 1 |
| Lavigne, C | 1 |
| Lund, AM | 1 |
| Martins, EG | 1 |
| Meavilla Olivas, S | 1 |
| Mention, K | 1 |
| Mochel, F | 1 |
| Mundy, H | 1 |
| Murphy, E | 1 |
| Paquay, S | 1 |
| Pedrón-Giner, C | 1 |
| Ruiz Gómez, MA | 1 |
| Santra, S | 1 |
| Schiff, M | 1 |
| Schwartz, IV | 1 |
| Scholl-Bürgi, S | 1 |
| Servais, A | 1 |
| Skouma, A | 1 |
| Tran, C | 1 |
| Vives Piñera, I | 1 |
| Walter, J | 1 |
| Weisfeld-Adams, J | 1 |
| Sukumar, N | 1 |
| Saravanan, P | 2 |
| Tan, A | 1 |
| Mattman, A | 1 |
| Sinclair, G | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1 Study of the Effect of Maternal Nutritional Status on Placental Vascular Function, Fetal Growth and Intrauterine Growth Retardation.[NCT01778205] | 831 participants (Actual) | Observational | 2005-01-31 | Completed | |||
| Effect of Maternal Choline Intake on Maternal/Fetal Biomarkers of Choline Status[NCT01127022] | 82 participants (Actual) | Interventional | 2009-01-31 | Completed | |||
| [NCT02244684] | 368 participants (Actual) | Observational | 2010-09-30 | Completed | |||
| Supplementation of Vitamin B12 in Pregnancy and Postpartum on Growth and Cognitive Functioning in Early Childhood: A Randomized, Placebo Controlled Trial[NCT03071666] | Phase 2/Phase 3 | 800 participants (Actual) | Interventional | 2017-03-27 | Active, not recruiting | ||
| Cobalamin Status in Young Children With Gastrointestinal Symptoms or Feeding Problems[NCT00710359] | 100 participants (Anticipated) | Interventional | 2008-04-30 | Completed | |||
| Cobalamin Supplementation During Infancy; Effect on B-vitamin Status, Growth and Psychomotor Development[NCT00479479] | 107 participants (Actual) | Interventional | 2004-12-31 | Completed | |||
| Cobalamin Status in Young Children With Developmental Delay and Regression[NCT00710138] | 100 participants (Anticipated) | Interventional | 2008-06-30 | Completed | |||
| Micronutrient Status in Pregnant and Lactating Women and Their Infants[NCT03272022] | 272 participants (Actual) | Observational | 2011-12-14 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for methylmalonic acid and Pregnancy
| Article | Year |
|---|---|
The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity.
Topics: Adiposity; Carbon Cycle; Diabetes Mellitus, Type 2; Environmental Exposure; Female; Fetal Developmen | 2014 |
Vitamin B-12 and neural tube defects: the Canadian experience.
Topics: Adult; Biological Availability; Biomarkers; Canada; Female; Flour; Folic Acid; Food, Fortified; Huma | 2009 |
Combined methylmalonic acidemia and homocystinuria, cblC type. I. Clinical presentations, diagnosis and management.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Carrier Proteins; Child; Child, Preschool; Female; | 2012 |
[Methylmalonic aciduria. Classification, diagnosis and therapy (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Female; Humans; Infant, Newborn; Ketosis; Malonates; Methylmal | 1977 |
The dietary treatment of inborn errors of metabolism.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Anemia, Megaloblastic; Child; Female; Folic Acid; | 1976 |
In utero treatment of fetal metabolic disorders.
Topics: Adrenal Hyperplasia, Congenital; Female; Fetal Diseases; Humans; Metabolism, Inborn Errors; Methylma | 1991 |
6 trials available for methylmalonic acid and Pregnancy
| Article | Year |
|---|---|
Maternal choline supplementation alters vitamin B-12 status in human and murine pregnancy.
Topics: Adult; Animals; Betaine-Homocysteine S-Methyltransferase; Choline; Choline Dehydrogenase; Dietary Su | 2019 |
Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal.
Topics: Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Nepal; Pregnancy; Vitamin B 12; Vitami | 2021 |
Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh.
Topics: Adolescent; Adult; Bangladesh; Biomarkers; C-Reactive Protein; Dietary Supplements; Dose-Response Re | 2016 |
Vitamin B-12 Status Differs among Pregnant, Lactating, and Control Women with Equivalent Nutrient Intakes.
Topics: Adult; Biomarkers; Breast Feeding; Choline; Dietary Supplements; Dose-Response Relationship, Drug; D | 2015 |
Biochemical indexes of the B vitamins in cord serum are predicted by maternal B vitamin status.
Topics: Adult; Female; Fetal Blood; Gestational Age; Homocysteine; Humans; Infant, Newborn; Male; Maternal-F | 2005 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
Determinants of cobalamin status in newborns.
Topics: Adult; Biomarkers; Female; Homocysteine; Humans; Infant, Newborn; Logistic Models; Maternal-Fetal Ex | 2001 |
106 other studies available for methylmalonic acid and Pregnancy
| Article | Year |
|---|---|
Comparing amniotic fluid mass spectrometry assays and amniocyte gene analyses for the prenatal diagnosis of methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Child; Female; Humans; Methylmalonic Acid; Pre | 2022 |
Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring.
Topics: Birth Weight; Child; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Pregnancy; | 2023 |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection.
Topics: Biomarkers; Early Diagnosis; Female; Homocysteine; Humans; Hydroxocobalamin; Infant; Infant Health; | 2022 |
Functional vitamin B12 deficiency: Improving methylmalonic acid reference intervals in urine.
Topics: Biomarkers; Female; Humans; Methylmalonic Acid; Pregnancy; Prospective Studies; Vitamin B 12; Vitami | 2023 |
A False-Positive Case of Methylmalonic Aciduria by Tandem Mass Spectrometry Newborn Screening Dependent on Maternal Malnutrition in Pregnancy.
Topics: Amino Acid Metabolism, Inborn Errors; Chromatography, Liquid; Female; Humans; Infant, Newborn; Malnu | 2020 |
Dietary Treatment from Birth to Pregnancy in a Woman with Methylmalonic Aciduria.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Diet; Dietary Supplements; Female; Humans; | 2021 |
Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women.
Topics: Adolescent; Adult; Cesarean Section; Cross-Sectional Studies; Depression, Postpartum; Diet; Female; | 2021 |
Considerations of expanded carrier screening: Lessons learned from combined malonic and methylmalonic aciduria.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amniocentesis; Carboxy-Lyases; Coenzyme A Ligases; Fema | 2021 |
Value of amniotic fluid homocysteine assay in prenatal diagnosis of combined methylmalonic acidemia and homocystinuria, cobalamin C type.
Topics: Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Female; Homocysteine; Homocystinuria; Humans; | 2021 |
Maternal vitamin B12 deficiency and perinatal outcomes in southern India.
Topics: Adult; Biomarkers; Cohort Studies; Female; Folic Acid; Humans; India; Infant, Newborn; Maternal Nutr | 2021 |
[MOLECULAR-GENETIC ASPECTS OF METHYLMALONIC ACIDURIA DEVELOPMENT (REVIEW)].
Topics: Amino Acid Metabolism, Inborn Errors; Child; Female; Humans; Methylmalonic Acid; Methylmalonyl-CoA M | 2021 |
South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women.
Topics: Adolescent; Adult; Asia; Biomarkers; Canada; Ethnicity; Female; Gestational Age; Humans; India; Meth | 2017 |
Early pregnancy folate-cobalamin interactions and their effects on cobalamin status and hematologic variables throughout pregnancy.
Topics: Adult; Anemia, Iron-Deficiency; Body Mass Index; Dietary Supplements; Female; Folic Acid; Homocystei | 2018 |
[Heterogeneous phenotypes, genotypes, treatment and prevention of 1 003 patients with methylmalonic acidemia in the mainland of China].
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Carrier Proteins; Child; Child, Preschool; | 2018 |
Phenotype, treatment practice and outcome in the cobalamin-dependent remethylation disorders and MTHFR deficiency: Data from the E-HOD registry.
Topics: Adolescent; Adult; Age of Onset; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Cros | 2019 |
Investigating vitamin B12 deficiency.
Topics: Adult; Aged; Biomarkers; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Infant; Malabsorp | 2019 |
Reference intervals for serum total vitamin B12 and holotranscobalamin concentrations and their change points with methylmalonic acid concentration to assess vitamin B12 status during early and mid-pregnancy.
Topics: Adult; Biomarkers; Female; Humans; Methylmalonic Acid; Pregnancy; Reference Values; Transcobalamins; | 2019 |
Pregnancy in a methylmalonic acidemia patient with kidney transplantation: a case report.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Female; Follow-Up Studies; Glomerular F | 2013 |
Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion.
Topics: Alleles; Animals; Calcification, Physiologic; DNA, Mitochondrial; Embryo Loss; Embryo, Mammalian; Em | 2014 |
Maternal vitamin B12 deficiency detected in expanded newborn screening.
Topics: Carnitine; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Neonatal S | 2014 |
Reliable and powerful laboratory markers of cobalamin deficiency in the newborn: plasma and urinary methylmalonic acid.
Topics: Adult; Biomarkers; Cohort Studies; Female; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid | 2016 |
Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women.
Topics: Adult; Canada; Diet; Dietary Supplements; DNA Methylation; Female; Fetal Blood; Fetus; Folic Acid; H | 2016 |
A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin.
Topics: Abnormalities, Multiple; Adolescent; Adult; Aged; Amino Acid Metabolism, Inborn Errors; Case-Control | 2016 |
A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women.
Topics: Adult; Female; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Middle Aged; Pregnancy; Pr | 2016 |
[Thromboembolic events, abortions and a sick infant--unusual presentation of a vitamin deficiency].
Topics: Abortion, Habitual; Adult; Anemia, Pernicious; Autoimmune Diseases; Breast Feeding; Diagnosis, Diffe | 2008 |
Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates.
Topics: Adult; Brazil; DNA; Embryonic Development; Ethnicity; Female; Folic Acid; Glutamate Carboxypeptidase | 2008 |
[Mutation analysis of the MMACHC gene in a pedigree with methylmalonic aciduria].
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; | 2009 |
Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria.
Topics: Adult; Ambulatory Care Facilities; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Methylmalo | 2009 |
Double aneuploidy (48,XXY,+21) of maternal origin in a child born to a 13-year-old mother: evaluation of the maternal folate metabolism.
Topics: Adolescent; Alleles; Aneuploidy; Brazil; Chromosomes, Human, X; Chromosomes, Human, Y; DNA Mutationa | 2009 |
Increased MMA concentration and body mass index are associated with spontaneous abortion in Brazilian women: a pilot study.
Topics: Abortion, Spontaneous; Adult; Alleles; Body Mass Index; Brazil; DNA Mutational Analysis; Female; Gen | 2010 |
Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12).
Topics: Amino Acid Sequence; Antigens, CD; Base Sequence; Cells, Cultured; DNA Mutational Analysis; Female; | 2010 |
Serum vitamin B(12) concentrations among mothers and newborns and follow-up study to assess implication on the growth velocity and the urinary methylmalonic acid excretion.
Topics: Adolescent; Adult; Birth Weight; Body Weight; Child Development; Female; Humans; Infant, Newborn; Li | 2009 |
Intact recovery from early 'acquired methylmalonic aciduria' secondary to maternal atrophic gastritis.
Topics: Amino Acid Metabolism, Inborn Errors; Dietary Supplements; Female; Gastritis, Atrophic; Humans; Infa | 2011 |
Prenatal diagnosis of methylmalonic aciduria by measuring methylmalonic acid in dried amniotic fluid on filter paper using gas chromatography-mass spectrometry.
Topics: Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Female; Gas Chromatography-Mass Spectrometry; | 2011 |
Uptake of cobalamin and markers of cobalamin status: a longitudinal study of healthy pregnant women.
Topics: Adult; Biomarkers; Denmark; Female; Homocysteine; Humans; Longitudinal Studies; Methylmalonic Acid; | 2011 |
Maternal risk for Down syndrome is modulated by genes involved in folate metabolism.
Topics: Adult; Betaine-Homocysteine S-Methyltransferase; Biosynthetic Pathways; Case-Control Studies; Down S | 2012 |
Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements.
Topics: Adult; Biomarkers; Dietary Supplements; Fatty Acids, Omega-3; Female; Folic Acid; Homocysteine; Huma | 2013 |
Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Apoptosis; Blotting, Western; Brain; Caspase 3; Cells | 2013 |
Vitamin B(12) intake and status in early pregnancy among urban South Indian women.
Topics: Adolescent; Adult; Anthropometry; Cross-Sectional Studies; Diet; Dietary Supplements; Erythrocytes; | 2013 |
Metabolic treatment of pregnancy and postdelivery period in a patient with cobalamin A disease.
Topics: Cobamides; Female; Humans; Hydroxocobalamin; Metabolism, Inborn Errors; Methylmalonic Acid; Pregnanc | 2002 |
Successful pregnancy in a woman with mut- methylmalonic acidaemia.
Topics: Adult; Carnitine; Female; Humans; Metabolism, Inborn Errors; Methylmalonic Acid; Pregnancy; Pregnanc | 2002 |
METHYLMALONIC ACID EXCRETION AND VITAMIN B12 DEFICIENCY IN THE HUMAN.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Carcinoma; Celiac Disease; Chromatography; Crohn Dis | 1964 |
Hematological parameters and cobalamin status in infants born to smoking mothers.
Topics: Adult; Birth Weight; Erythrocyte Count; Female; Folic Acid; Gestational Age; Hemoglobins; Homocystei | 2004 |
An infant with methylmalonic aciduria and homocystinuria (cblC) presenting with retinal haemorrhages and subdural haematoma mimicking non-accidental injury.
Topics: Child Abuse; Diagnosis, Differential; Female; Hematoma; Hematoma, Subdural; Homocystinuria; Humans; | 2004 |
Methylmalonic acid in amniotic fluid and maternal urine as a marker for neural tube defects.
Topics: Adult; Amniotic Fluid; Biomarkers; Female; Folic Acid; Humans; Methylmalonic Acid; Neural Tube Defec | 2004 |
Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency.
Topics: Cystathionine; Cystatin C; Cystatins; Female; Folic Acid; HELLP Syndrome; Homocysteine; Humans; Hype | 2004 |
Prenatal diagnosis for organic acid disorders using two mass spectrometric methods, gas chromatography mass spectrometry and tandem mass spectrometry.
Topics: Amniotic Fluid; Carboxylic Acids; Carnitine; Female; Fetal Diseases; Gas Chromatography-Mass Spectro | 2005 |
Methylmalonic acidaemia: a rare metabolic disorder in pregnancy.
Topics: Adult; Cesarean Section; Female; Humans; Infant, Newborn; Infant, Premature; Metabolism, Inborn Erro | 2004 |
Genetic and biochemical approach to early prenatal diagnosis in a family with mut methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Base Sequence; DNA Mutational Analysis; Family Health; Female; | 2006 |
Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Anemia, Pernicious; Autoimmune Diseases; Biomarkers; Carnitine; | 2005 |
Cobalamin status during normal pregnancy and postpartum: a longitudinal study comprising 406 Danish women.
Topics: Adult; Cohort Studies; Denmark; Female; Follow-Up Studies; Hemoglobins; Homocysteine; Humans; Infant | 2006 |
Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alleles; Analysis of V | 2008 |
Reference intervals for haematological variables during normal pregnancy and postpartum in 434 healthy Danish women.
Topics: Creatinine; Denmark; Female; Ferritins; Folic Acid; Hematologic Tests; Homocysteine; Humans; Methylm | 2007 |
Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring.
Topics: Adult; Female; Fetus; Health; Humans; Longitudinal Studies; Maternal Nutritional Physiological Pheno | 2007 |
Methylmalonic acidaemia in a 7-month-old following maternal highly active antiretroviral therapy during pregnancy.
Topics: Amino Acid Metabolism, Inborn Errors; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female | 2007 |
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study.
Topics: Adipose Tissue; Anthropometry; Body Composition; Body Mass Index; Child; Female; Folic Acid; Homocys | 2008 |
Selective screening for inborn errors of metabolism and secondary methylmalonic aciduria in pregnancy at high risk district of neural tube defects: a human metabolome study by GC-MS in China.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; China; Female; Gas | 2008 |
Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid.
Topics: Amniotic Fluid; Carnitine; Citrates; Female; Gas Chromatography-Mass Spectrometry; Homocysteine; Hum | 2008 |
First-trimester (chorion biopsy) diagnosis of citrullinaemia and methylmalonicaciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Chorionic Villi; Citrulline; Female; Humans; Malonates; Methyl | 1984 |
Experience with prenatal diagnosis of propionic acidaemia and methylmalonic aciduria.
Topics: Amniotic Fluid; Carboxy-Lyases; Female; Humans; Malonates; Methylmalonic Acid; Methylmalonyl-CoA Dec | 1984 |
Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids, Branched-Chain; Amniotic Fluid; Caproates; Female | 1984 |
Identification of methyl-branched chain dicarboxylic acids in amniotic fluid and urine in propionic and methylmalonic acidemia.
Topics: Amniotic Fluid; Chromatography, Gas; Dicarboxylic Acids; Female; Humans; Malonates; Mass Spectrometr | 1984 |
The stable isotope dilution method for measurement of methylmalonic acid: a highly accurate approach to the prenatal diagnosis of methylmalonic acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Female; Gas Chromatography-Mass Spectrometry; | 1982 |
Isotope dilution analysis of methylcitric acid in amniotic fluid for the prenatal diagnosis of propionic and methylmalonic acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Chromatography, Liquid; Citrates; Female; Gas | 1980 |
Methylmalonic acid in low-fat milk syndrome.
Topics: Acetates; Animal Feed; Animals; Cattle; Cattle Diseases; Fatty Acids; Female; Lactation; Malonates; | 1981 |
Effects of cobalt deficiency in pregnant and post-parturient ewes and their lambs.
Topics: Adipose Tissue; Animals; Animals, Newborn; Cobalt; Female; Lipid Metabolism; Liver; Methylmalonic Ac | 1981 |
Improved prenatal diagnosis of methylmalonic acidemia: mass fragmentography of methylmalonic acid in amniotic fluid and maternal urine.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Female; Humans; Malonates; Methylmaloni | 1981 |
Prenatal diagnosis and therapy for a patient with vitamin B12-responsive methylmalonic acidaemia.
Topics: Female; Fetal Diseases; Humans; Metabolism, Inborn Errors; Methylmalonic Acid; Pregnancy; Prenatal D | 1995 |
Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects.
Topics: Adult; Case-Control Studies; Female; Folic Acid; Gas Chromatography-Mass Spectrometry; Humans; Methy | 1995 |
Free amino acids in amniotic fluid and the prenatal diagnosis of homocystinuria with methylmalonic aciduria.
Topics: Amino Acids; Amniocentesis; Amniotic Fluid; Female; Gestational Age; Homocystinuria; Humans; Methylm | 1995 |
Evaluation of prenatal treatment in newborns with cobalamin-responsive methylmalonic acidaemia.
Topics: Adipose Tissue; Fatty Acids; Female; Humans; Infant, Newborn; Metabolism, Inborn Errors; Methylmalon | 1995 |
Biochemical indices of vitamin B12 nutrition in pregnant patients with subnormal serum vitamin B12 levels.
Topics: Female; Homocysteine; Humans; Methylmalonic Acid; Nutritional Status; Pregnancy; Pregnancy Complicat | 1995 |
Homocysteine metabolism in pregnancies complicated by neural-tube defects.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Female; Folic Acid; | 1995 |
Methylmalonic aciduria in pregnancy: a case report.
Topics: Adult; Female; Humans; Infant, Newborn; Metabolism, Inborn Errors; Methylmalonic Acid; Pregnancy; Pr | 1995 |
Prenatal diagnosis of combined methylmalonic aciduria and homocystinuria (cobalamin CblC or CblD mutant)
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cobamides; Female; Homocystinuria; Humans | 1994 |
In vitro and in vivo inactivation of transcobalamin II receptor by its antiserum.
Topics: Animals; Antibodies; Cell Line; Cell Membrane; Cobalt Radioisotopes; Female; Homocysteine; Humans; I | 1996 |
Clinical heterogeneity and prognosis in combined methylmalonic aciduria and homocystinuria (cblC).
Topics: Adolescent; Age of Onset; Amino Acid Metabolism, Inborn Errors; Cause of Death; Child; Child, Presch | 1997 |
[Megaloblastic anemia: rapid and economical study].
Topics: Adolescent; Adult; Algorithms; Anemia, Megaloblastic; Cost Control; Diagnosis, Differential; Diagnos | 1997 |
Reliability of biochemical parameters used in prenatal diagnosis of combined methylmalonic aciduria and homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Amniocentesis; Amniotic Fluid; Cells, Cultured; Chorion; Chori | 1998 |
Turn of tide for oral vitamin B12 treatment.
Topics: Administration, Oral; Aged; Biological Availability; Biomarkers; England; Female; Homocysteine; Huma | 1999 |
Successful pregnancy in severe methylmalonic acidaemia.
Topics: Acidosis; Adult; Female; Humans; Hydroxocobalamin; Infant, Newborn; Male; Metabolism, Inborn Errors; | 1999 |
Evaluation of low serum vitamin B(12) in the non-anaemic pregnant patient.
Topics: Adult; Erythrocyte Indices; Female; Gestational Age; Homocysteine; Humans; Methylmalonic Acid; Parit | 2000 |
Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy.
Topics: Adult; Biomarkers; Female; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Pregnanc | 2001 |
Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered?
Topics: Adolescent; Adult; Biomarkers; Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Fol | 2001 |
Total homocysteine is making its way into pediatric laboratory diagnostics.
Topics: Adult; Avitaminosis; Child; Diagnosis, Differential; Female; Folic Acid; Folic Acid Deficiency; HIV | 2001 |
Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity.
Topics: Animals; Cells, Cultured; Citrates; Citric Acid Cycle; Corpus Striatum; Electron Transport Complex I | 2002 |
Detection of errors in methylmalonyl-CoA metabolism by using amniotic fluid.
Topics: Amniotic Fluid; Cells, Cultured; Coenzyme A; False Positive Reactions; Female; Humans; Malonates; Me | 1977 |
Prenatal therapy of a patient with vitamin-B12-responsive methylmalonic acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Cobamides; Female; Fetal Diseases; Gestational | 1975 |
Functional significance of low serum vitamin B12 levels in pregnancy.
Topics: Biological Assay; Female; Hematocrit; Hemoglobins; Humans; Methylmalonic Acid; Pregnancy; Pregnancy | 1977 |
Methylmalonate excretion in a pregnancy at risk for methylmalonic acidaemia.
Topics: Female; Humans; Infant, Newborn; Male; Malonates; Metabolism, Inborn Errors; Methylmalonic Acid; Pre | 1978 |
A technique for measurement of methylmalonic acid in cattle urine.
Topics: Animals; Cattle; Female; Lactation; Malonates; Methylmalonic Acid; Pregnancy; Propionates | 1977 |
Editorial: Prenatal treatment of methylmalonic acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Amniocentesis; Female; Fetal Diseases; Humans; Infant, Newborn | 1975 |
Cardiac structure and function in vitamin B-12-deprived rats.
Topics: Animals; Fatty Acids; Female; Maternal-Fetal Exchange; Methylmalonic Acid; Mitochondria, Muscle; Myo | 1975 |
Microdetermination of methylmalonic acid and other short chain dicarboxylic acids by gas chromatography: use in prenatal diagnosis of methylmalonic acidemia and in studies of isovaleric acidemia.
Topics: Adult; Child; Chromatography, Gas; Colorimetry; Dicarboxylic Acids; Evaluation Studies as Topic; Fem | 1976 |
Eleventh week amniocentesis for prenatal diagnosis of some metabolic diseases.
Topics: Amniocentesis; Amniotic Fluid; Argininosuccinic Acid; Chorionic Villi Sampling; Citrulline; Female; | 1991 |
Accumulation of odd-numbered long-chain fatty acids in fetuses and neonates with inherited disorders of propionate metabolism.
Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Fatty Acids; Female; Fetus; Humans; Infant, N | 1991 |
Effect of cobalt deficiency in the pregnant ewe on reproductive performance and lamb viability.
Topics: Animals; Body Weight; Cobalt; Colostrum; Female; Fetal Death; Immunoglobulin G; Methylmalonic Acid; | 1991 |
Prenatal treatment of a patient with vitamin B12-responsive methylmalonic acidemia.
Topics: Acidosis; Administration, Oral; Female; Humans; Metabolism, Inborn Errors; Methylmalonic Acid; Pregn | 1990 |
Prenatal diagnosis of propionic and methylmalonic acidaemia by stable isotope dilution analysis of amniotic fluid.
Topics: Amino Acid Metabolism, Inborn Errors; Amniocentesis; Citrates; Female; Gas Chromatography-Mass Spect | 1989 |
Duration of effective benefit from administration of graded oral doses of cobalt to sheep.
Topics: Animals; Benzimidazoles; Cobalt; Drug Administration Schedule; Female; Fenbendazole; Lactation; Meth | 1989 |
First trimester diagnosis of methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Chorionic Villi; Female; Humans; Malonates; Methylmalonic Acid | 1988 |
Methylcitric acid determination in amniotic fluid by electron-impact mass fragmentography.
Topics: Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Citrates; Female; Gas Chromatography-Mass Spec | 1988 |
Familial supernumerary non-satellited microchromosome.
Topics: Adult; Chromosome Aberrations; Chromosome Banding; Female; Genetic Markers; Humans; Male; Metabolism | 1986 |
Biochemical fetal therapy.
Topics: Adrenal Hyperplasia, Congenital; Adult; Arrhythmias, Cardiac; Copper; Female; Fetal Diseases; Galact | 1986 |
Prenatal treatment of biochemical disorders.
Topics: Adrenal Hyperplasia, Congenital; Female; Fetal Diseases; Galactosemias; Humans; Metabolism, Inborn E | 1985 |
Hyperuricemia in children, with the exception of the Lesch-Nyhan syndrome.
Topics: Acidosis; Acute Disease; Acute Kidney Injury; Adult; Child; Child, Preschool; Chronic Disease; Femal | 1974 |