methylmalonic acid has been researched along with Peripheral Nerve Diseases in 11 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylmalonic aciduria and homocystinuria, cblC type, is the most common inborn error of vitamin B(12) (cobalamin) metabolism." | 7.76 | Early onset methylmalonic aciduria and homocystinuria cblC type with demyelinating neuropathy. ( Della Giustina, E; Frattini, D; Fusco, C; Tavazzi, B; Ucchino, V, 2010) |
| "Methylmalonic aciduria and homocystinuria, cblC type, is the most common inborn error of vitamin B(12) (cobalamin) metabolism." | 3.76 | Early onset methylmalonic aciduria and homocystinuria cblC type with demyelinating neuropathy. ( Della Giustina, E; Frattini, D; Fusco, C; Tavazzi, B; Ucchino, V, 2010) |
| "Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN)." | 1.62 | The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus. ( El-Sherif, M; Esmael, A; Hashem, MM; Nassar, AK, 2021) |
| "Vegetarians have Vitamin B12 deficiency and are more prone to developing neuropsychiatric and neurological problems." | 1.46 | Neuropsychiatric and neurological problems among Vitamin B12 deficient young vegetarians. ( Baig, M; Kapoor, A; Karmani, H; Memon, AS; Tunio, SA, 2017) |
| "Since both cancer and neurotoxic antineoplastic agents increase oxidative stress, a role for functional B12 deficiency in CIPN was considered." | 1.43 | Functional vitamin B12 deficiency in advanced malignancy: implications for the management of neuropathy and neuropathic pain. ( Solomon, LR, 2016) |
| "Metformin-treated patients had depressed Cbl levels and elevated fasting MMA and Hcy levels." | 1.36 | Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. ( Toth, C; Wile, DJ, 2010) |
| " Cumulative lifetime L-dopa dosage and fasting MMA levels were associated with PN severity." | 1.35 | Neuropathy as a potential complication of levodopa use in Parkinson's disease. ( Brown, MS; Furtado, S; Suchowersky, O; Toth, C; Zochodne, D, 2008) |
| "Methylmalonic acid was measured by mass spectrometry and homocysteine by HPLC." | 1.31 | Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to vitamin B12 deficiency. ( Allen, RH; Barbé, FM; Droesch, S; Gaire, D; Lambert, DA; Nicolas, JP; Sponne, IE; Stabler, SP, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Paul, DA | 1 |
| Qureshi, ARM | 1 |
| Rana, AQ | 1 |
| Hashem, MM | 1 |
| Esmael, A | 1 |
| Nassar, AK | 1 |
| El-Sherif, M | 1 |
| Kapoor, A | 1 |
| Baig, M | 1 |
| Tunio, SA | 1 |
| Memon, AS | 1 |
| Karmani, H | 1 |
| Oberlin, BS | 1 |
| Tangney, CC | 1 |
| Gustashaw, KA | 1 |
| Rasmussen, HE | 1 |
| Solomon, LR | 1 |
| Toth, C | 3 |
| Brown, MS | 1 |
| Furtado, S | 1 |
| Suchowersky, O | 2 |
| Zochodne, D | 1 |
| Wile, DJ | 1 |
| Breithaupt, K | 1 |
| Ge, S | 1 |
| Duan, Y | 1 |
| Terris, JM | 1 |
| Thiessen, A | 1 |
| Wiebe, S | 1 |
| Zochodne, DW | 1 |
| Frattini, D | 1 |
| Fusco, C | 1 |
| Ucchino, V | 1 |
| Tavazzi, B | 1 |
| Della Giustina, E | 1 |
| Sponne, IE | 1 |
| Gaire, D | 1 |
| Stabler, SP | 1 |
| Droesch, S | 1 |
| Barbé, FM | 1 |
| Allen, RH | 1 |
| Lambert, DA | 1 |
| Nicolas, JP | 1 |
| Yao, Y | 1 |
| Yao, SL | 1 |
| Yao, SS | 1 |
| Yao, G | 1 |
| Lou, W | 1 |
1 review available for methylmalonic acid and Peripheral Nerve Diseases
| Article | Year |
|---|---|
Peripheral neuropathy in Parkinson's disease.
Topics: Humans; Levodopa; Methylmalonic Acid; Parkinson Disease; Peripheral Nervous System Diseases; Vitamin | 2020 |
10 other studies available for methylmalonic acid and Peripheral Nerve Diseases
| Article | Year |
|---|---|
The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Homocysteine; Humans; Male; Metformin; Met | 2021 |
Neuropsychiatric and neurological problems among Vitamin B12 deficient young vegetarians.
Topics: Adult; Case-Control Studies; Comorbidity; Cross-Sectional Studies; Depression; Female; Folic Acid; H | 2017 |
Vitamin B12 deficiency in relation to functional disabilities.
Topics: Activities of Daily Living; Aged; Biomarkers; Cognition; Disability Evaluation; Disabled Persons; Fe | 2013 |
Functional vitamin B12 deficiency in advanced malignancy: implications for the management of neuropathy and neuropathic pain.
Topics: Aged; Female; Humans; Male; Methylmalonic Acid; Middle Aged; Neoplasms; Neuralgia; Peripheral Nervou | 2016 |
Neuropathy as a potential complication of levodopa use in Parkinson's disease.
Topics: Analysis of Variance; Antiparkinson Agents; Female; Homocysteine; Humans; Levodopa; Male; Methylmalo | 2008 |
Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy.
Topics: Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Neuropathies; Electrophys | 2010 |
Levodopa, methylmalonic acid, and neuropathy in idiopathic Parkinson disease.
Topics: Aged; Antiparkinson Agents; Cohort Studies; Databases, Factual; Fasting; Female; Humans; Levodopa; M | 2010 |
Early onset methylmalonic aciduria and homocystinuria cblC type with demyelinating neuropathy.
Topics: Demyelinating Diseases; Female; Genetic Association Studies; Homocystinuria; Humans; Infant; Methylm | 2010 |
Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to vitamin B12 deficiency.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media, Conditioned; Homocysteine; Humans; Methyl | 2000 |
Prevalence of vitamin B12 deficiency among geriatric outpatients.
Topics: Aged; Aged, 80 and over; Female; Gastritis, Atrophic; Homocysteine; Humans; Male; Methylmalonic Acid | 1992 |