methylmalonic acid has been researched along with Neuroblastoma in 2 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylmalonic acidemia is a rare metabolic disorder caused by the deficient activity of l-methylmalonyl-CoA mutase or its cofactor 5-deoxyadenosylcobalamin and is characterized by accumulation of methylmalonic acid (MMA) and alternative metabolites." | 5.62 | Methylmalonic Acid Compromises Respiration and Reduces the Expression of Differentiation Markers of SH-SY5Y Human Neuroblastoma Cells. ( Carrettiero, DC; da Costa, RT; de Almeida, RP; Dos Santos, MB; Ribeiro, CAJ; Silva, ICS; Teruel, MS, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| da Costa, RT | 1 |
| Dos Santos, MB | 1 |
| Silva, ICS | 1 |
| de Almeida, RP | 1 |
| Teruel, MS | 1 |
| Carrettiero, DC | 1 |
| Ribeiro, CAJ | 1 |
| Lemieux, B | 1 |
| Auray-Blais, C | 1 |
| Giguère, R | 1 |
| Scriver, CR | 1 |
2 other studies available for methylmalonic acid and Neuroblastoma
| Article | Year |
|---|---|
Methylmalonic Acid Compromises Respiration and Reduces the Expression of Differentiation Markers of SH-SY5Y Human Neuroblastoma Cells.
Topics: Antigens, Differentiation; Humans; Infant, Newborn; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Ne | 2021 |
Neuroblastoma screening: the Canadian experience.
Topics: Amino Acids; Canada; Chromatography, Thin Layer; False Positive Reactions; Homovanillic Acid; Humans | 1989 |