methylmalonic acid has been researched along with Nervous System Diseases in 21 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Characteristic features in such patients included paresthesia, sensory loss, ataxia, dementia, and psychiatric disorders; longstanding neurologic symptoms without anemia; normal white-cell and platelet counts and serum bilirubin and lactate dehydrogenase levels; and markedly elevated serum concentrations of methylmalonic acid and total homocysteine." | 3.67 | Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. ( Allen, RH; Brust, JC; Garrett, TJ; Healton, EB; Lindenbaum, J; Marcell, PD; Podell, ER; Savage, DG; Stabler, SP, 1988) |
| " We discuss the importance of methylmalonic acid dosage after bariatric surgery in patients who present suspect of cyanocobalamin deficiency with normal values of this vitamin and the role of proton pump inhibitor use and vitamin supplementation in patients with early neurological presentation." | 2.47 | The importance of methylmalonic acid dosage on the assessment of patients with neurological manifestations following bariatric surgery. ( Cosmo, C; Lucena, R; Vieira, C, 2011) |
| "Diagnosis of vitamin B12 deficiency is typically based on measurement of serum vitamin B12 levels; however, about 50 percent of patients with subclinical disease have normal B12 levels." | 2.42 | Vitamin B12 deficiency. ( Brown, DL; Oh, R, 2003) |
| "Neuropathies often accompany vitamin B12 deficiency." | 1.43 | Vitamin B12-responsive neuropathies: A case series. ( Solomon, LR, 2016) |
| "Neurological dysfunction due to vitamin B12 deficiency is most prominent in patients with mild to moderate anaemia." | 1.29 | Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe. ( Bennie, A; Gangaidzo, I; Gwanzura, C; Kiire, C; Lindenbaum, J; Moyo, A; Mudenge, B; Mukiibi, JM; Savage, D; Sitima, J, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Ailliet, S | 1 |
| Vandenberghe, R | 1 |
| Schiemsky, T | 1 |
| Van Overbeke, L | 1 |
| Demaerel, P | 1 |
| Meersseman, W | 1 |
| Cassiman, D | 1 |
| Vermeersch, P | 1 |
| Solomon, LR | 1 |
| Cosson, MA | 1 |
| Benoist, JF | 2 |
| Touati, G | 1 |
| Déchaux, M | 1 |
| Royer, N | 1 |
| Grandin, L | 1 |
| Jais, JP | 1 |
| Boddaert, N | 1 |
| Barbier, V | 1 |
| Desguerre, I | 1 |
| Campeau, PM | 1 |
| Rabier, D | 1 |
| Valayannopoulos, V | 1 |
| Niaudet, P | 1 |
| de Lonlay, P | 1 |
| Vieira, C | 1 |
| Cosmo, C | 1 |
| Lucena, R | 1 |
| Nyhan, WL | 1 |
| Gargus, JJ | 1 |
| Boyle, K | 1 |
| Selby, R | 1 |
| Koch, R | 1 |
| Oh, R | 1 |
| Brown, DL | 1 |
| Roze, E | 1 |
| Gervais, D | 1 |
| Demeret, S | 1 |
| Ogier de Baulny, H | 1 |
| Zittoun, J | 1 |
| Said, G | 1 |
| Pierrot-Deseilligny, C | 1 |
| Bolgert, F | 1 |
| Hörster, F | 1 |
| Baumgartner, MR | 1 |
| Viardot, C | 1 |
| Suormala, T | 1 |
| Burgard, P | 1 |
| Fowler, B | 1 |
| Hoffmann, GF | 1 |
| Garbade, SF | 1 |
| Kölker, S | 1 |
| Baumgartner, ER | 1 |
| Shevell, MI | 2 |
| Matiaszuk, N | 1 |
| Ledley, FD | 1 |
| Rosenblatt, DS | 3 |
| Savage, D | 1 |
| Gangaidzo, I | 1 |
| Lindenbaum, J | 3 |
| Kiire, C | 1 |
| Mukiibi, JM | 1 |
| Moyo, A | 1 |
| Gwanzura, C | 1 |
| Mudenge, B | 1 |
| Bennie, A | 1 |
| Sitima, J | 1 |
| Allen, RH | 2 |
| Stabler, SP | 2 |
| Aspler, AL | 1 |
| Pletcher, BA | 1 |
| Fenton, WA | 1 |
| Seashore, MR | 1 |
| Snow, CF | 1 |
| van't Hoff, W | 1 |
| McKiernan, PJ | 1 |
| Surtees, RA | 1 |
| Leonard, JV | 1 |
| de Jong, N | 1 |
| Chin A Paw, MJ | 1 |
| de Groot, LC | 1 |
| Rutten, RA | 1 |
| Swinkels, DW | 1 |
| Kok, FJ | 1 |
| van Staveren, WA | 1 |
| Chanarin, I | 1 |
| Deacon, R | 1 |
| Lumb, M | 1 |
| Perry, J | 1 |
| Vieira-Makings, E | 1 |
| Chetty, N | 1 |
| Reavis, SC | 1 |
| Metz, J | 1 |
| Commodari, F | 1 |
| Arnold, DL | 1 |
| Sanctuary, BC | 1 |
| Shoubridge, EA | 1 |
| Kühne, T | 1 |
| Bubl, R | 1 |
| Baumgartner, R | 1 |
| Carmel, R | 1 |
| Watkins, D | 1 |
| Goodman, SI | 1 |
| Healton, EB | 1 |
| Savage, DG | 1 |
| Brust, JC | 1 |
| Garrett, TJ | 1 |
| Podell, ER | 1 |
| Marcell, PD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy[NCT00699478] | Phase 2 | 30 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for methylmalonic acid and Nervous System Diseases
| Article | Year |
|---|---|
The importance of methylmalonic acid dosage on the assessment of patients with neurological manifestations following bariatric surgery.
Topics: Female; Gastric Bypass; Humans; Methylmalonic Acid; Nervous System Diseases; Obesity; Vitamin B 12 D | 2011 |
Vitamin B12 deficiency.
Topics: Humans; Malabsorption Syndromes; Mental Disorders; Methylmalonic Acid; Nervous System Diseases; Prac | 2003 |
High prevalence of cobalamin deficiency in the elderly.
Topics: Aged; Hematologic Diseases; Homocysteine; Humans; Mental Disorders; Methylmalonic Acid; Nervous Syst | 1996 |
Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician.
Topics: Antibodies; Clinical Laboratory Techniques; Clinical Trials as Topic; Decision Trees; Diagnosis, Dif | 1999 |
Cobalamin and folate: recent developments.
Topics: Anemia, Megaloblastic; Female; Folic Acid; Humans; Methylation; Methylmalonic Acid; Nervous System D | 1992 |
2 trials available for methylmalonic acid and Nervous System Diseases
| Article | Year |
|---|---|
Neuropsychiatric disturbances in presumed late-onset cobalamin C disease.
Topics: Adolescent; Adult; Brain; Cobamides; Female; Fibroblasts; Homocysteine; Humans; Mental Disorders; Me | 2003 |
Nutrient-dense foods and exercise in frail elderly: effects on B vitamins, homocysteine, methylmalonic acid, and neuropsychological functioning.
Topics: Aged; Aged, 80 and over; Cohort Studies; Cross-Sectional Studies; Dietary Supplements; Exercise; Fem | 2001 |
14 other studies available for methylmalonic acid and Nervous System Diseases
| Article | Year |
|---|---|
A case of vitamin B12 deficiency neurological syndrome in a young adult due to late-onset cobalamin C (CblC) deficiency: a diagnostic challenge.
Topics: Adult; Female; Folic Acid; Humans; Methylmalonic Acid; Nervous System Diseases; Vitamin B 12; Vitami | 2022 |
Vitamin B12-responsive neuropathies: A case series.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antioxidants; Biotransformation; Female; Homoc | 2016 |
Long-term outcome in methylmalonic aciduria: a series of 30 French patients.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Disease Progressio | 2009 |
Progressive neurologic disability in methylmalonic acidemia despite transplantation of the liver.
Topics: Acute Kidney Injury; Adult; Disease Progression; Female; Humans; Liver Transplantation; Metabolism, | 2002 |
Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB).
Topics: Adolescent; Adult; Age of Onset; Alkyl and Aryl Transferases; Amino Acid Metabolism, Inborn Errors; | 2007 |
Varying neurological phenotypes among muto and mut- patients with methylmalonylCoA mutase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Cell Line; Child; Child, Preschool; Developmental Disabilities | 1993 |
Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe.
Topics: Anemia, Megaloblastic; Anemia, Pernicious; Erythrocyte Indices; Female; Folic Acid; Folic Acid Defic | 1994 |
Clinical heterogeneity and prognosis in combined methylmalonic aciduria and homocystinuria (cblC).
Topics: Adolescent; Age of Onset; Amino Acid Metabolism, Inborn Errors; Cause of Death; Child; Child, Presch | 1997 |
Liver transplantation for methylmalonic acidaemia.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Kidney Transplantation; Liver Transplan | 1999 |
Methylmalonic acid metabolism and nervous-system fatty acids in cobalamin-deficient fruit bats receiving supplements of methionine, valine and isoleucine.
Topics: Amino Acids; Animals; Brain; Chiroptera; Fatty Acids; Isoleucine; Liver; Methionine; Methylmalonic A | 1991 |
1H NMR characterization of normal human cerebrospinal fluid and the detection of methylmalonic acid in a vitamin B12 deficient patient.
Topics: Adult; Aged; Female; Humans; Magnetic Resonance Spectroscopy; Male; Methylmalonic Acid; Middle Aged; | 1991 |
Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency.
Topics: Adult; Breast Feeding; Diet, Vegetarian; Female; Homocysteine; Humans; Infant; Methionine; Methylmal | 1991 |
Hereditary defect of cobalamin metabolism (cblG mutation) presenting as a neurologic disorder in adulthood.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Diagnosis, Differential; Female; H | 1988 |
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.
Topics: Adolescent; Adult; Aged; Anemia; Anemia, Megaloblastic; Ataxia; Erythrocyte Indices; Erythrocytes; F | 1988 |