methylmalonic acid has been researched along with Multiple Sclerosis in 3 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vrethem, M | 1 |
| Mattsson, E | 1 |
| Hebelka, H | 1 |
| Leerbeck, K | 1 |
| Osterberg, A | 1 |
| Landtblom, AM | 1 |
| Balla, B | 1 |
| Nilsson, H | 1 |
| Hultgren, M | 1 |
| Brattström, L | 1 |
| Kågedal, B | 1 |
| Goodkin, DE | 1 |
| Jacobsen, DW | 1 |
| Galvez, N | 1 |
| Daughtry, M | 1 |
| Secic, M | 1 |
| Green, R | 1 |
| Carmel, R | 1 |
| Watkins, D | 1 |
| Goodman, SI | 1 |
| Rosenblatt, DS | 1 |
3 other studies available for methylmalonic acid and Multiple Sclerosis
| Article | Year |
|---|---|
Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid.
Topics: Adult; Aged; Aged, 80 and over; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; | 2003 |
Serum cobalamin deficiency is uncommon in multiple sclerosis.
Topics: Adult; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Multiple Sclerosis; Muscular Diseases; | 1994 |
Hereditary defect of cobalamin metabolism (cblG mutation) presenting as a neurologic disorder in adulthood.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Diagnosis, Differential; Female; H | 1988 |