methylmalonic acid has been researched along with Mental Disorders in 12 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on the case of a 36-year-old Hispanic woman with a spinal cord infarct, who was subsequently diagnosed with methylmalonic aciduria and homocystinuria, cblC type (cblC)." | 7.74 | Late-onset combined homocystinuria and methylmalonic aciduria (cblC) and neuropsychiatric disturbance. ( Lerner-Ellis, JP; Morel, CF; Rosenblatt, DS; Scharer, G; Thomas, JA; Tsai, AC; Yang, M, 2007) |
| "The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20)." | 5.29 | Serum cobalamin and methylmalonic acid in Alzheimer dementia. ( Christensen, JE; Gulmann, NC; Kristensen, MO; Ostergaard, K; Rasmussen, K, 1993) |
| "We report on the case of a 36-year-old Hispanic woman with a spinal cord infarct, who was subsequently diagnosed with methylmalonic aciduria and homocystinuria, cblC type (cblC)." | 3.74 | Late-onset combined homocystinuria and methylmalonic aciduria (cblC) and neuropsychiatric disturbance. ( Lerner-Ellis, JP; Morel, CF; Rosenblatt, DS; Scharer, G; Thomas, JA; Tsai, AC; Yang, M, 2007) |
| "Diagnosis of vitamin B12 deficiency is typically based on measurement of serum vitamin B12 levels; however, about 50 percent of patients with subclinical disease have normal B12 levels." | 2.42 | Vitamin B12 deficiency. ( Brown, DL; Oh, R, 2003) |
| "The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20)." | 1.29 | Serum cobalamin and methylmalonic acid in Alzheimer dementia. ( Christensen, JE; Gulmann, NC; Kristensen, MO; Ostergaard, K; Rasmussen, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nilsson, K | 3 |
| Gustafson, L | 3 |
| Hultberg, B | 3 |
| Oh, R | 1 |
| Brown, DL | 1 |
| Gültepe, M | 1 |
| Ozcan, O | 1 |
| Avşar, K | 1 |
| Cetin, M | 1 |
| Ozdemir, AS | 1 |
| Gök, M | 1 |
| Roze, E | 1 |
| Gervais, D | 1 |
| Demeret, S | 1 |
| Ogier de Baulny, H | 1 |
| Zittoun, J | 1 |
| Benoist, JF | 1 |
| Said, G | 1 |
| Pierrot-Deseilligny, C | 1 |
| Bolgert, F | 1 |
| Tsai, AC | 1 |
| Morel, CF | 1 |
| Scharer, G | 1 |
| Yang, M | 1 |
| Lerner-Ellis, JP | 1 |
| Rosenblatt, DS | 1 |
| Thomas, JA | 1 |
| Brett, AS | 1 |
| Roberts, MS | 1 |
| Kristensen, MO | 1 |
| Gulmann, NC | 1 |
| Christensen, JE | 1 |
| Ostergaard, K | 1 |
| Rasmussen, K | 1 |
| Allen, RH | 2 |
| Lindenbaum, J | 2 |
| Stabler, SP | 2 |
| Fäldt, R | 1 |
| Anderson, A | 1 |
| Vaara, I | 1 |
| Nilsson, R | 1 |
| Alm, B | 1 |
| van Asselt, DZ | 1 |
| Karlietis, MH | 1 |
| Poels, PJ | 1 |
| de Jong, JG | 1 |
| Wevers, RA | 1 |
| Hoefnagels, WH | 1 |
| Isaksson, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy[NCT00699478] | Phase 2 | 30 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for methylmalonic acid and Mental Disorders
| Article | Year |
|---|---|
Vitamin B12 deficiency.
Topics: Humans; Malabsorption Syndromes; Mental Disorders; Methylmalonic Acid; Nervous System Diseases; Prac | 2003 |
High prevalence of cobalamin deficiency in the elderly.
Topics: Aged; Hematologic Diseases; Homocysteine; Humans; Mental Disorders; Methylmalonic Acid; Nervous Syst | 1996 |
Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders.
Topics: Central Nervous System Diseases; Citrates; Demyelinating Diseases; Folic Acid; Homocysteine; Humans; | 1998 |
[Homocysteine and methylmalonic acid as markers of cobalamin/folate status. The association to neuropsychiatric symptoms in the elderly is explored].
Topics: Aged; Biomarkers; Cognition Disorders; Diagnosis, Differential; Folic Acid Deficiency; Geriatric Psy | 2000 |
1 trial available for methylmalonic acid and Mental Disorders
| Article | Year |
|---|---|
Neuropsychiatric disturbances in presumed late-onset cobalamin C disease.
Topics: Adolescent; Adult; Brain; Cobamides; Female; Fibroblasts; Homocysteine; Humans; Mental Disorders; Me | 2003 |
7 other studies available for methylmalonic acid and Mental Disorders
| Article | Year |
|---|---|
Optimal use of markers for cobalamin and folate status in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition Disorders; Female; Folic Acid; Hom | 2002 |
Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders.
Topics: Adult; Aged; Folic Acid; Homocysteine; Humans; Mental Disorders; Methylmalonic Acid; Middle Aged; Ph | 2003 |
Late-onset combined homocystinuria and methylmalonic aciduria (cblC) and neuropsychiatric disturbance.
Topics: Adult; Carrier Proteins; Female; Homocystinuria; Humans; Mental Disorders; Metabolism, Inborn Errors | 2007 |
Screening for vitamin B12 deficiency in psychiatric patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Homocysteine; Humans; Male; Mental Disorders; Me | 1994 |
Serum cobalamin and methylmalonic acid in Alzheimer dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Diagnosis, Differential; Erythrocyte In | 1993 |
Plasma methylmalonic acid in relation to serum cobalamin and plasma homocysteine in a psychogeriatric population and the effect of cobalamin treatment.
Topics: Aged; Biomarkers; Case-Control Studies; Drug Monitoring; Female; Geriatric Psychiatry; Homocysteine; | 1997 |
Cerebrospinal fluid methylmalonic acid concentrations in neurological patients with low and normal serum cobalamin concentrations.
Topics: Adult; Aged; Brain Diseases; Female; Humans; Male; Mental Disorders; Methylmalonic Acid; Middle Aged | 1998 |