methylmalonic acid has been researched along with Kidney Failure, Chronic in 35 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal failure causes hyperhomocysteinemia, an important risk factor for cardiovascular disease and venous access thrombosis in end-stage renal disease (ESRD)." | 9.10 | Hydroxocobalamin reduces hyperhomocysteinemia in end-stage renal disease. ( Elian, KM; Hoffer, LJ, 2002) |
| " Randomized placebo-controlled clinical trials of longer duration and using larger or more frequent parenteral doses are indicated to determine whether administration of this safe and inexpensive vitamin can improve hyperhomocysteinemia in ESRD." | 9.09 | Parenteral vitamin B12 reduces hyperhomocysteinemia in end-stage renal disease. ( Hoffer, LJ; Kaplan, LN; Mamer, OA, 2001) |
| "Presently pregnancy is no more exceptional in women with metabolic diseases." | 5.39 | Pregnancy in a methylmalonic acidemia patient with kidney transplantation: a case report. ( Bellelli, E; Carducci, C; Elli, M; Gentile, I; Labriola, D; Lubrano, R; Paoli, S; Pérez, B; Santagata, S; Ugarte, M, 2013) |
| "Renal failure causes hyperhomocysteinemia, an important risk factor for cardiovascular disease and venous access thrombosis in end-stage renal disease (ESRD)." | 5.10 | Hydroxocobalamin reduces hyperhomocysteinemia in end-stage renal disease. ( Elian, KM; Hoffer, LJ, 2002) |
| " Randomized placebo-controlled clinical trials of longer duration and using larger or more frequent parenteral doses are indicated to determine whether administration of this safe and inexpensive vitamin can improve hyperhomocysteinemia in ESRD." | 5.09 | Parenteral vitamin B12 reduces hyperhomocysteinemia in end-stage renal disease. ( Hoffer, LJ; Kaplan, LN; Mamer, OA, 2001) |
| " This study was undertaken to assess whether high serum levels of total homocysteine (tHcy) with its metabolites methylmalonic acid (MMA), methylcitric acid (MCA) and cystathionine (CYSTA) as well as elevated serum concentrations of the AGEs pentosidine and Nepsilon-carboxymethyllysine (CML) are independent risk factors for CVD, left ventricular hypertrophy (LVH) or hypertension as well as kidney dysfunction in renal transplant recipients (RTR)." | 3.72 | Serum levels of total homocysteine, homocysteine metabolites and of advanced glycation end-products (AGEs) in patients after renal transplantation. ( Busch, M; Franke, S; Kientsch-Engel, R; Müller, A; Sommer, M; Stein, G, 2003) |
| "End-stage renal disease (ESRD) is associated with moderately severe hyperhomocysteinemia that is incompletely normalized by oral folic acid therapy and vitamin B12." | 3.72 | Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease. ( Elian, KM; Hoffer, LJ, 2004) |
| "Hyperhomocysteinemia, a well-recognized cardiovascular risk factor, is frequent in hemodialysis (HD) patients." | 3.71 | Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients. ( Funamizu, M; Hata, A; Hayashi, K; Hiejima, Y; Hirayama, H; Kawabata, M; Makita, Y; Nakamura, T; Saionji, K; Tago, K; Tajiri, M; Takano, H, 2002) |
| "Methylmalonic acidemia (MMA) is an inborn error of organic acid metabolism." | 2.44 | Renal transplant in methylmalonic acidemia: could it be the best option? Report on a case at 10 years and review of the literature. ( Barsotti, P; Berloco, P; Carducci, C; Elli, M; Lubrano, R; Raggi, C; Rossi, M; Travasso, E, 2007) |
| "Intellectual disability was equally distributed among the initial treatment groups, while renal failure (moderate and beginning at the age of 38 years) was present in only one out of seven patients initially treated with B12." | 1.72 | Very long-term outcomes in 23 patients with cblA type methylmalonic acidemia. ( Acquaviva, C; Benoist, JF; Brassier, A; Cano, A; Chabrol, B; De Lonlay, P; Fouilhoux, A; Guffon-Fouilhoux, N; Lachmann, R; Marelli, C; Murphy, E; Pennisi, A; Schiff, M; Servais, A, 2022) |
| "Maleic acid (MA) has been shown to induce Fanconi syndrome via disturbance of renal energy homeostasis, though the underlying pathomechanism is still under debate." | 1.42 | Maleic Acid--but Not Structurally Related Methylmalonic Acid--Interrupts Energy Metabolism by Impaired Calcium Homeostasis. ( Kölker, S; Morath, MA; Okun, JG; Ruppert, T; Sauer, SW; Tuncel, AT; Wang, BT, 2015) |
| "Presently pregnancy is no more exceptional in women with metabolic diseases." | 1.39 | Pregnancy in a methylmalonic acidemia patient with kidney transplantation: a case report. ( Bellelli, E; Carducci, C; Elli, M; Gentile, I; Labriola, D; Lubrano, R; Paoli, S; Pérez, B; Santagata, S; Ugarte, M, 2013) |
| "Methylmalonic acid (MMA) level was used as an indicator of vitamin B12 status." | 1.37 | Parenteral vitamin B12 in macrocytic hemodialysis patients reduced MMA levels but did not change mean red cell volume or hemoglobin. ( Jastrzebski, J; Li, G; Martyn, A; Shalansky, K; Snyder, F; Su, VC; Yeung, CK; Zalunardo, N, 2011) |
| "Diabetic nephropathy is a common complication in patients with type 2 diabetes that may increase atherothrombotic risk." | 1.33 | Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes. ( Fowler, B; Herrmann, W; Kuhlmann, MK; Makowski, J; Obeid, R; Schorr, H, 2005) |
| "Methylmalonic acidaemia (MMA) is a rare autosomal recessive inborn error of metabolism that typically presents in infancy with recurrent episodes of metabolic acidosis, developmental delay and failure to thrive." | 1.33 | Management of methylmalonic acidaemia by combined liver-kidney transplantation. ( Enns, GM; Millan, MT; Nagarajan, S; Sarwal, MM; Winter, S, 2005) |
| "Renal tubular dysfunction and chronic renal failure are well recognised complications of methylmalonic acidaemia (MMA) and can occur even in the context of optimal medical metabolic management." | 1.33 | Renal transplantation in a 14-year-old girl with vitamin B12-responsive cblA-type methylmalonic acidaemia. ( Burke, J; Coman, D; Huang, J; McGill, J; McTaggart, S; Ohura, T; Sakamoto, O, 2006) |
| "Methylmalonic acidemia (MMA) is an inborn error of organic acid metabolism that occurs in infancy with hypotonia, vomiting, dehydration, lethargy and failure to thrive and is biochemically characterized by metabolic ketoacidosis, hyperammonemia and sometimes hyperglycinemia." | 1.31 | Kidney transplantation in a girl with methylmalonic acidemia and end stage renal failure. ( Barsotti, P; Castello, MA; Cristaldi, S; Lubrano, R; Scateni, S; Scoppi, P; Travasso, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.86) | 18.7374 |
| 1990's | 5 (14.29) | 18.2507 |
| 2000's | 22 (62.86) | 29.6817 |
| 2010's | 5 (14.29) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Marelli, C | 1 |
| Fouilhoux, A | 1 |
| Benoist, JF | 2 |
| De Lonlay, P | 2 |
| Guffon-Fouilhoux, N | 1 |
| Brassier, A | 1 |
| Cano, A | 1 |
| Chabrol, B | 1 |
| Pennisi, A | 1 |
| Schiff, M | 1 |
| Acquaviva, C | 1 |
| Murphy, E | 1 |
| Servais, A | 1 |
| Lachmann, R | 1 |
| Hörster, F | 5 |
| Tuncel, AT | 2 |
| Gleich, F | 1 |
| Plessl, T | 1 |
| Froese, SD | 1 |
| Garbade, SF | 2 |
| Kölker, S | 5 |
| Baumgartner, MR | 2 |
| Lubrano, R | 3 |
| Bellelli, E | 1 |
| Gentile, I | 1 |
| Paoli, S | 1 |
| Carducci, C | 3 |
| Santagata, S | 1 |
| Pérez, B | 1 |
| Ugarte, M | 1 |
| Labriola, D | 1 |
| Elli, M | 2 |
| Iqbal, N | 1 |
| Azar, D | 1 |
| Yun, YM | 1 |
| Ghausi, O | 1 |
| Ix, J | 1 |
| Fitzgerald, RL | 1 |
| Vernon, HJ | 1 |
| Sperati, CJ | 1 |
| King, JD | 1 |
| Poretti, A | 1 |
| Miller, NR | 1 |
| Sloan, JL | 1 |
| Cameron, AM | 1 |
| Myers, D | 1 |
| Venditti, CP | 1 |
| Valle, D | 1 |
| Ruppert, T | 1 |
| Wang, BT | 1 |
| Okun, JG | 2 |
| Morath, MA | 2 |
| Sauer, SW | 2 |
| Etuwewe, B | 1 |
| Jones, CA | 1 |
| Mathur, S | 1 |
| Wright, KP | 1 |
| Morris, AA | 1 |
| Cosson, MA | 1 |
| Touati, G | 1 |
| Déchaux, M | 1 |
| Royer, N | 1 |
| Grandin, L | 1 |
| Jais, JP | 1 |
| Boddaert, N | 1 |
| Barbier, V | 1 |
| Desguerre, I | 1 |
| Campeau, PM | 1 |
| Rabier, D | 1 |
| Valayannopoulos, V | 1 |
| Niaudet, P | 1 |
| Saito, T | 1 |
| Saito, O | 1 |
| Maeda, T | 1 |
| Ito, C | 1 |
| Ando, Y | 1 |
| Yamagata, T | 1 |
| Muto, S | 1 |
| Momoi, M | 1 |
| Kusano, E | 1 |
| Su, VC | 1 |
| Shalansky, K | 1 |
| Jastrzebski, J | 1 |
| Martyn, A | 1 |
| Li, G | 1 |
| Yeung, CK | 1 |
| Snyder, F | 1 |
| Zalunardo, N | 1 |
| Hyndman, ME | 1 |
| Manns, BJ | 1 |
| Snyder, FF | 1 |
| Bridge, PJ | 1 |
| Scott-Douglas, NW | 1 |
| Fung, E | 1 |
| Parsons, HG | 1 |
| Franke, S | 1 |
| Müller, A | 1 |
| Sommer, M | 1 |
| Busch, M | 1 |
| Kientsch-Engel, R | 1 |
| Stein, G | 1 |
| Paik, KH | 1 |
| Lee, JE | 1 |
| Jin, DK | 1 |
| Hoffer, LJ | 3 |
| Elian, KM | 2 |
| Schmitt, CP | 1 |
| Mehls, O | 1 |
| Trefz, FK | 1 |
| Weber, TL | 1 |
| Hoffmann, GF | 3 |
| Obeid, R | 4 |
| Kuhlmann, MK | 2 |
| Köhler, H | 1 |
| Herrmann, W | 4 |
| Kuhlmann, M | 1 |
| Kirsch, CM | 1 |
| Schorr, H | 2 |
| Geisel, J | 1 |
| Makowski, J | 1 |
| Fowler, B | 2 |
| Nagarajan, S | 1 |
| Enns, GM | 1 |
| Millan, MT | 1 |
| Winter, S | 1 |
| Sarwal, MM | 1 |
| Coman, D | 1 |
| Huang, J | 1 |
| McTaggart, S | 1 |
| Sakamoto, O | 1 |
| Ohura, T | 1 |
| McGill, J | 1 |
| Burke, J | 1 |
| Rossi, M | 1 |
| Travasso, E | 2 |
| Raggi, C | 1 |
| Barsotti, P | 2 |
| Berloco, P | 1 |
| Viardot, C | 1 |
| Suormala, T | 1 |
| Burgard, P | 1 |
| Baumgartner, ER | 1 |
| Müller, IB | 1 |
| van 't Hoff, WG | 1 |
| Dixon, M | 1 |
| Taylor, J | 1 |
| Mistry, P | 1 |
| Rolles, K | 1 |
| Rees, L | 1 |
| Leonard, JV | 2 |
| Van Calcar, SC | 1 |
| Harding, CO | 1 |
| Lyne, P | 1 |
| Hogan, K | 1 |
| Banerjee, R | 1 |
| Sollinger, H | 1 |
| Rieselbach, RE | 1 |
| Wolff, JA | 1 |
| Dierkes, J | 1 |
| Domröse, U | 1 |
| Ambrosch, A | 1 |
| Schneede, J | 1 |
| Guttormsen, AB | 1 |
| Neumann, KH | 1 |
| Luley, C | 1 |
| Henning, BF | 1 |
| Riezler, R | 1 |
| Tepel, M | 1 |
| Langer, K | 1 |
| Raidt, H | 1 |
| Graefe, U | 1 |
| Zidek, W | 1 |
| Kaplan, LN | 1 |
| Mamer, OA | 1 |
| Scoppi, P | 1 |
| Scateni, S | 1 |
| Cristaldi, S | 1 |
| Castello, MA | 1 |
| Nakamura, T | 1 |
| Saionji, K | 1 |
| Hiejima, Y | 1 |
| Hirayama, H | 1 |
| Tago, K | 1 |
| Takano, H | 1 |
| Tajiri, M | 1 |
| Hayashi, K | 1 |
| Kawabata, M | 1 |
| Funamizu, M | 1 |
| Makita, Y | 1 |
| Hata, A | 1 |
| Rasmussen, K | 1 |
| Vyberg, B | 1 |
| Pedersen, KO | 1 |
| Brøchner-Mortensen, J | 1 |
| Walter, JH | 1 |
| Michalski, A | 1 |
| Wilson, WM | 1 |
| Barratt, TM | 1 |
| Dillon, MJ | 1 |
3 reviews available for methylmalonic acid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Pathophysiology, diagnosis, and treatment of methylmalonic aciduria-recent advances and new challenges.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Humans; Kidney Failure, Chronic; Methylmalonic Acid | 2004 |
Renal transplant in methylmalonic acidemia: could it be the best option? Report on a case at 10 years and review of the literature.
Topics: Adult; Female; Follow-Up Studies; Humans; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplan | 2007 |
Neurodegeneration and chronic renal failure in methylmalonic aciduria--a pathophysiological approach.
Topics: Animals; Brain; Dicarboxylic Acids; Energy Metabolism; Humans; Kidney; Kidney Failure, Chronic; Meth | 2008 |
3 trials available for methylmalonic acid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Vitamin B12 decreases, but does not normalize, homocysteine and methylmalonic acid in end-stage renal disease: a link with glycine metabolism and possible explanation of hyperhomocysteinemia in end-stage renal disease.
Topics: Cysteine; Genotype; Glycine; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Me | 2003 |
Parenteral vitamin B12 reduces hyperhomocysteinemia in end-stage renal disease.
Topics: Cysteine; Homocysteine; Humans; Hyperhomocysteinemia; Injections, Subcutaneous; Kidney Failure, Chro | 2001 |
Hydroxocobalamin reduces hyperhomocysteinemia in end-stage renal disease.
Topics: Aged; Female; Folic Acid; Homocysteine; Humans; Hydroxocobalamin; Hyperhomocysteinemia; Injections, | 2002 |
29 other studies available for methylmalonic acid and Kidney Failure, Chronic
| Article | Year |
|---|---|
Very long-term outcomes in 23 patients with cblA type methylmalonic acidemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Child; Humans; Intellectual Disability; Kidney Failure, | 2022 |
Delineating the clinical spectrum of isolated methylmalonic acidurias: cblA and mut.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Cross-Sectional Studies; Female; Glomerular Filtration | 2021 |
Pregnancy in a methylmalonic acidemia patient with kidney transplantation: a case report.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Amniotic Fluid; Female; Follow-Up Studies; Glomerular F | 2013 |
Serum methylmalonic acid and holotranscobalamin-II as markers for vitamin B12 deficiency in end-stage renal disease patients.
Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Female; Humans; Kidney Failure, Chronic; | 2013 |
A detailed analysis of methylmalonic acid kinetics during hemodialysis and after combined liver/kidney transplantation in a patient with mut (0) methylmalonic acidemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Female; Humans; Kidney; Kidney Failure, Chronic; Kidney | 2014 |
Maleic Acid--but Not Structurally Related Methylmalonic Acid--Interrupts Energy Metabolism by Impaired Calcium Homeostasis.
Topics: Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Energy Metabolism; Homeostasis; Humans; | 2015 |
Peritoneal dialysis for chronic renal failure in a patient with methylmalonic acidaemia.
Topics: Amino Acid Metabolism, Inborn Errors; Humans; Infant; Kidney Failure, Chronic; Kidney Transplantatio | 2009 |
Long-term outcome in methylmalonic aciduria: a series of 30 French patients.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Disease Progressio | 2009 |
Metabolic and hemodynamic advantages of an acetate-free citrate dialysate in a uremic case of congenital methylmalonic acidemia.
Topics: Acetates; Adult; Amino Acid Metabolism, Inborn Errors; Blood Pressure; Citrates; Female; Heart Rate; | 2009 |
Parenteral vitamin B12 in macrocytic hemodialysis patients reduced MMA levels but did not change mean red cell volume or hemoglobin.
Topics: Aged; Aged, 80 and over; Anemia, Macrocytic; Biomarkers; Chi-Square Distribution; Erythrocyte Indice | 2011 |
Serum levels of total homocysteine, homocysteine metabolites and of advanced glycation end-products (AGEs) in patients after renal transplantation.
Topics: Adult; Arginine; Coronary Disease; Cystathionine; Female; Glycation End Products, Advanced; Homocyst | 2003 |
Successful dialysis in a boy with methylmalonic acidemia.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Humans; Kidney Failure, Chronic; Male; Methylmalonic Ac | 2004 |
Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease.
Topics: Administration, Oral; Aged; Folic Acid; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Methy | 2004 |
Reversible end-stage renal disease in an adolescent patient with methylmalonic aciduria.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Diet, Protein-Restricted; Humans; Kidney Failure, | 2004 |
Response of homocysteine, cystathionine, and methylmalonic acid to vitamin treatment in dialysis patients.
Topics: Aged; Aged, 80 and over; Cystathionine; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; | 2005 |
Cellular uptake of vitamin B12 in patients with chronic renal failure.
Topics: Adult; Aged; Cells, Cultured; Cystathionine; Female; Homocysteine; Humans; Kidney Failure, Chronic; | 2005 |
The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings.
Topics: Adult; Age Factors; Aged; Biomarkers; Female; Humans; Kidney Failure, Chronic; Male; Methylmalonic A | 2005 |
Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes.
Topics: Aged; Cystathionine; Cysteine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid | 2005 |
Management of methylmalonic acidaemia by combined liver-kidney transplantation.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Body Mass Index; Body Weight; Child; Developmental | 2005 |
Renal transplantation in a 14-year-old girl with vitamin B12-responsive cblA-type methylmalonic acidaemia.
Topics: Adolescent; Cobamides; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Metabolism, | 2006 |
Long-term outcome in methylmalonic acidurias is influenced by the underlying defect (mut0, mut-, cblA, cblB).
Topics: Adolescent; Adult; Age of Onset; Alkyl and Aryl Transferases; Amino Acid Metabolism, Inborn Errors; | 2007 |
Combined liver-kidney transplantation in methylmalonic acidemia.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Genes, Recessive; Humans; Kidney Failure, Chronic; | 1998 |
Renal transplantation in a patient with methylmalonic acidaemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Female; Humans; Kidney Failure, Chronic; Kidney Transpl | 1998 |
Supplementation with vitamin B12 decreases homocysteine and methylmalonic acid but also serum folate in patients with end-stage renal disease.
Topics: Adult; Aged; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Genotype; Homocysteine | 1999 |
Evidence of altered homocysteine metabolism in chronic renal failure.
Topics: Arteriosclerosis; Citrates; Creatinine; Cystathionine; Cysteine; Female; Homocysteine; Humans; Kidne | 1999 |
Kidney transplantation in a girl with methylmalonic acidemia and end stage renal failure.
Topics: Adolescent; Female; Follow-Up Studies; Humans; Kidney; Kidney Failure, Chronic; Kidney Transplantati | 2001 |
Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients.
Topics: Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Genotype; H | 2002 |
Methylmalonic acid in renal insufficiency: evidence of accumulation and implications for diagnosis of cobalamin deficiency.
Topics: Adult; Creatinine; False Positive Reactions; Female; Humans; Kidney Failure, Chronic; Male; Malonate | 1990 |
Chronic renal failure in methylmalonic acidaemia.
Topics: Biopsy; Female; Humans; Infant; Infant, Newborn; Kidney; Kidney Failure, Chronic; Kidney Function Te | 1989 |