methylmalonic acid has been researched along with Disease Models, Animal in 20 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In vivo characteristics of isatins [(18)F]-2 and [(18)F]-3 were studied and compared by μPET to previously described 1-[4-(2-[(18)F]fluoroethyl)benzyl]-5-(2-methoxymethylpyrrolidin-1-ylsulfonyl)isatin ([(18)F]-1) and to 2-(5-[(18)F]fluoropentyl)-2-methyl-malonic acid ([(18)F]ML-10) used as a reference radiotracer in a rat stroke model." | 3.83 | In Vivo Evaluation of Radiofluorinated Caspase-3/7 Inhibitors as Radiotracers for Apoptosis Imaging and Comparison with [18F]ML-10 in a Stroke Model in the Rat. ( Barré, L; Delamare, J; Dhilly, M; Fraser, BH; Greguric, I; Krause-Heuer, AM; Matesic, L; Médoc, M; Sobrio, F; Toutain, J; Touzani, O, 2016) |
| "Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurologic dysfunction, including seizures." | 3.78 | Prostaglandin E(2) potentiates methylmalonate-induced seizures. ( Banderó, CR; Bortoluzzi, VT; Bueno, LM; Gomes, AT; Jesse, AC; Mello, CF; Oliveira, MS; Rambo, LM; Salvadori, MG, 2012) |
| " The body weight of the mice fed on a B12-deficient diet for 90 days was slightly lower than that of the control mice administrated CN-B12, and the urinary excretion of methylmalonic acid (MMA) was increased." | 3.72 | Breeding severely vitamin B12-deficient mice as model animals. ( Arai, K; Funada, U; Kawata, T; Kuwamori, M; Maekawa, A; Matsushita, M; Sanai, T; Tadokoro, T; Tanaka, N; Wada, M; Yamada, H; Yamamoto, Y, 2004) |
| "Hyperhomocysteinemia adversely affects fundamental aspects of fetal development, adulthood, and aging, but the role of elevated homocysteine levels in these birth defects and adult diseases remains unclear." | 3.71 | Genetic and molecular control of folate-homocysteine metabolism in mutant mice. ( Bale, A; Balling, R; Christensen, B; Colmenares, C; Ernest, S; Gilfix, BM; Hosack, A; Mamer, OA; McGrath, J; Nadeau, JH; Rodier, M; Rosenblatt, DS; Sankoff, D, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 11 (55.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lucienne, M | 1 |
| Aguilar-Pimentel, JA | 1 |
| Amarie, OV | 1 |
| Becker, L | 1 |
| Calzada-Wack, J | 1 |
| da Silva-Buttkus, P | 1 |
| Garrett, L | 1 |
| Hölter, SM | 1 |
| Mayer-Kuckuk, P | 1 |
| Rathkolb, B | 1 |
| Rozman, J | 1 |
| Spielmann, N | 1 |
| Treise, I | 1 |
| Busch, DH | 1 |
| Klopstock, T | 1 |
| Schmidt-Weber, C | 1 |
| Wolf, E | 1 |
| Wurst, W | 1 |
| Forny, M | 1 |
| Mathis, D | 2 |
| Fingerhut, R | 2 |
| Froese, DS | 2 |
| Gailus-Durner, V | 1 |
| Fuchs, H | 1 |
| de Angelis, MH | 1 |
| Baumgartner, MR | 2 |
| Médoc, M | 1 |
| Dhilly, M | 1 |
| Matesic, L | 1 |
| Toutain, J | 1 |
| Krause-Heuer, AM | 1 |
| Delamare, J | 1 |
| Fraser, BH | 1 |
| Touzani, O | 1 |
| Barré, L | 1 |
| Greguric, I | 1 |
| Sobrio, F | 1 |
| Colín-González, AL | 1 |
| Paz-Loyola, AL | 1 |
| Serratos, I | 1 |
| Seminotti, B | 1 |
| Ribeiro, CA | 1 |
| Leipnitz, G | 1 |
| Souza, DO | 1 |
| Wajner, M | 4 |
| Santamaría, A | 1 |
| Hyafil, F | 1 |
| Tran-Dinh, A | 1 |
| Burg, S | 1 |
| Leygnac, S | 1 |
| Louedec, L | 1 |
| Milliner, M | 1 |
| Ben Azzouna, R | 1 |
| Reshef, A | 2 |
| Ben Ami, M | 1 |
| Meilhac, O | 1 |
| Le Guludec, D | 1 |
| Forny, P | 1 |
| Schumann, A | 1 |
| Mustedanagic, M | 1 |
| Wulf, MA | 1 |
| Nägele, N | 1 |
| Langhans, CD | 1 |
| Zhakupova, A | 1 |
| Heeren, J | 1 |
| Scheja, L | 1 |
| Peters, HL | 2 |
| Hornemann, T | 1 |
| Thony, B | 1 |
| Kölker, S | 1 |
| Burda, P | 1 |
| Devuyst, O | 1 |
| Shirvan, A | 1 |
| Waterhouse, RN | 1 |
| Grimberg, H | 1 |
| Levin, G | 1 |
| Cohen, A | 1 |
| Ulysse, LG | 1 |
| Friedman, G | 1 |
| Antoni, G | 1 |
| Ziv, I | 1 |
| Salvadori, MG | 1 |
| Banderó, CR | 1 |
| Jesse, AC | 1 |
| Gomes, AT | 1 |
| Rambo, LM | 1 |
| Bueno, LM | 1 |
| Bortoluzzi, VT | 1 |
| Oliveira, MS | 2 |
| Mello, CF | 2 |
| Buck, NE | 1 |
| Dashnow, H | 1 |
| Pitt, JJ | 1 |
| Wood, LR | 1 |
| Royes, LF | 1 |
| Fighera, MR | 1 |
| Furian, AF | 1 |
| da Silva, LG | 1 |
| Malfatti, CR | 1 |
| Schneider, PH | 1 |
| Braga, AL | 1 |
| Das, AM | 1 |
| Pettenuzzo, LF | 1 |
| Wyse, AT | 1 |
| Wannmacher, CM | 1 |
| Dutra-Filho, CS | 1 |
| Netto, CA | 1 |
| Kawata, T | 2 |
| Funada, U | 1 |
| Wada, M | 2 |
| Matsushita, M | 1 |
| Sanai, T | 1 |
| Yamada, H | 1 |
| Kuwamori, M | 1 |
| Arai, K | 1 |
| Yamamoto, Y | 1 |
| Tanaka, N | 2 |
| Tadokoro, T | 2 |
| Maekawa, A | 2 |
| Takada, N | 1 |
| Ogita, K | 1 |
| Taguchi, T | 1 |
| Masumoto, K | 1 |
| Suita, S | 1 |
| Vasques, V | 1 |
| Brinco, F | 1 |
| Viegas, CM | 1 |
| Yamada, K | 1 |
| Mori, K | 1 |
| Tamai, H | 1 |
| Tobimatsu, T | 1 |
| Toraya, T | 1 |
| Chandler, RJ | 2 |
| Sloan, J | 1 |
| Fu, H | 1 |
| Tsai, M | 1 |
| Stabler, S | 1 |
| Allen, R | 1 |
| Kaestner, KH | 1 |
| Kazazian, HH | 1 |
| Venditti, CP | 2 |
| Scalabrino, G | 1 |
| Buccellato, FR | 1 |
| Tredici, G | 1 |
| Morabito, A | 1 |
| Lorenzini, EC | 1 |
| Allen, RH | 1 |
| Lindenbaum, J | 1 |
| Ernest, S | 1 |
| Christensen, B | 1 |
| Gilfix, BM | 1 |
| Mamer, OA | 1 |
| Hosack, A | 1 |
| Rodier, M | 1 |
| Colmenares, C | 1 |
| McGrath, J | 1 |
| Bale, A | 1 |
| Balling, R | 1 |
| Sankoff, D | 1 |
| Rosenblatt, DS | 1 |
| Nadeau, JH | 1 |
| Bailey, LB | 1 |
| Molloy, A | 1 |
| Scott, J | 1 |
| Rice, D | 1 |
1 review available for methylmalonic acid and Disease Models, Animal
| Article | Year |
|---|---|
Regulation of the mitochondrial ATP-synthase in health and disease.
Topics: Animals; Brain; Brain Diseases, Metabolic, Inborn; Cells, Cultured; Chickens; Disease; Disease Model | 2003 |
19 other studies available for methylmalonic acid and Disease Models, Animal
| Article | Year |
|---|---|
In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Anxiety; Bone Density; Disease Models, Animal; Female | 2020 |
In Vivo Evaluation of Radiofluorinated Caspase-3/7 Inhibitors as Radiotracers for Apoptosis Imaging and Comparison with [18F]ML-10 in a Stroke Model in the Rat.
Topics: Animals; Apoptosis; Caspase 3; Caspase 7; Caspase Inhibitors; Disease Models, Animal; Isatin; Male; | 2016 |
Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Disease Models, Ani | 2015 |
Detection of Apoptotic Cells in a Rabbit Model with Atherosclerosis-Like Lesions Using the Positron Emission Tomography Radiotracer [18F]ML-10.
Topics: Animals; Aorta; Atherosclerosis; Disease Models, Animal; Fluorine Radioisotopes; Injections; Male; M | 2015 |
Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Biomarkers; Brain; Carnitine; Dietary Protei | 2016 |
Molecular imaging of neurovascular cell death in experimental cerebral stroke by PET.
Topics: Animals; Apoptosis; Disease Models, Animal; Male; Methylmalonic Acid; Molecular Probe Techniques; Ne | 2008 |
Prostaglandin E(2) potentiates methylmalonate-induced seizures.
Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Electrodes, I | 2012 |
Development of transgenic mice containing an introduced stop codon on the human methylmalonyl-CoA mutase locus.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Breeding; Codon, Nonsense; Disease Models, Animal; Fe | 2012 |
Creatine protects against the convulsive behavior and lactate production elicited by the intrastriatal injection of methylmalonate.
Topics: Animals; Behavior, Animal; Corpus Striatum; Creatine; Disease Models, Animal; Dizocilpine Maleate; D | 2003 |
Evaluation of the effect of chronic administration of drugs on rat behavior in the water maze task.
Topics: Animals; Behavior, Animal; Brain; Brain Diseases, Metabolic; Cognition Disorders; Disease Models, An | 2003 |
Breeding severely vitamin B12-deficient mice as model animals.
Topics: Animals; Body Weight; Diet; Disease Models, Animal; Liver; Male; Maternal Nutritional Physiological | 2004 |
Effect of a valine-rich diet on a rat model of short bowel syndrome.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Male; Methylmalonic Acid; Rats; Rats, In | 2005 |
Creatine prevents behavioral alterations caused by methylmalonic acid administration into the hippocampus of rats in the open field task.
Topics: Animals; Avoidance Learning; Brain Diseases, Metabolic, Inborn; Creatine; Disease Models, Animal; En | 2006 |
Testicular injury to rats fed on soybean protein-based vitamin B12-deficient diet can be reduced by methionine supplementation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Animals; Body Weigh | 2007 |
Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle.
Topics: Adult; Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Disease Models, Animal; Fem | 2007 |
Adenovirus-mediated gene delivery rescues a neonatal lethal murine model of mut(0) methylmalonic acidemia.
Topics: Adenoviridae; Animals; Animals, Newborn; Disease Models, Animal; Gene Transfer Techniques; Genetic T | 2008 |
Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Pernicious; Animals; Bacteria, An | 1997 |
Genetic and molecular control of folate-homocysteine metabolism in mutant mice.
Topics: Animals; Blotting, Northern; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation; | 2002 |
Streptozotocin-induced diabetes is not a model for methylmalonic acidaemia.
Topics: Animals; Chromatography, Gas; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Malonat | 1989 |