methylmalonic acid has been researched along with Diabetic Neuropathies in 4 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN)." | 1.62 | The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus. ( El-Sherif, M; Esmael, A; Hashem, MM; Nassar, AK, 2021) |
| "The 176 Chinese patients with Type 2 diabetes mellitus were divided into 3 groups according to the levels of vitamin B12." | 1.40 | Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes. ( Chen, SH; Li, XB; Liu, XH; Liu, YT; Ni, YH; Sun, AL; Zhuang, XH, 2014) |
| "Metformin-treated patients had depressed Cbl levels and elevated fasting MMA and Hcy levels." | 1.36 | Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. ( Toth, C; Wile, DJ, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashem, MM | 1 |
| Esmael, A | 1 |
| Nassar, AK | 1 |
| El-Sherif, M | 1 |
| Sun, AL | 1 |
| Ni, YH | 1 |
| Li, XB | 1 |
| Zhuang, XH | 1 |
| Liu, YT | 1 |
| Liu, XH | 1 |
| Chen, SH | 1 |
| Wile, DJ | 1 |
| Toth, C | 1 |
| WHITE, AM | 1 |
| COX, EV | 1 |
4 other studies available for methylmalonic acid and Diabetic Neuropathies
| Article | Year |
|---|---|
The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Homocysteine; Humans; Male; Metformin; Met | 2021 |
Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes.
Topics: Adult; Aged; Asian People; Biomarkers; China; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Fema | 2014 |
Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy.
Topics: Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Neuropathies; Electrophys | 2010 |
METHYLMALONIC ACID EXCRETION AND VITAMIN B12 DEFICIENCY IN THE HUMAN.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Carcinoma; Celiac Disease; Chromatography; Crohn Dis | 1964 |