methylmalonic acid has been researched along with Diabetes Mellitus in 5 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Forty-seven percent of the subjects had cobalamin deficiency (total cobalamin <150 pmol/L), 73% had low holoTC (<35 pmol/L), 77% had hyperhomocysteinemia (tHcy >15 micromol/L), and 73% had elevated serum MMA (>0." | 7.71 | Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. ( Gadkari, M; Guttormsen, AB; Joglekar, A; Orning, L; Refsum, H; Sayyad, MG; Schneede, J; Ueland, PM; Ulvik, A; Vollset, SE; Yajnik, CS, 2001) |
| "We report on a female neonate with diabetes mellitus and methylmalonic acidaemia, who died at age 16 days." | 7.68 | Congenital absence of insulin cells in a neonate with diabetes mellitus and mutase-deficient methylmalonic acidaemia. ( Baumgartner, R; Blum, D; De Prez, C; Dorchy, H; Fowler, B; Heimann, P; Kumps, A; Mardens, Y; Mouraux, T; Vamos, E, 1993) |
| " Forty-seven percent of the subjects had cobalamin deficiency (total cobalamin <150 pmol/L), 73% had low holoTC (<35 pmol/L), 77% had hyperhomocysteinemia (tHcy >15 micromol/L), and 73% had elevated serum MMA (>0." | 3.71 | Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. ( Gadkari, M; Guttormsen, AB; Joglekar, A; Orning, L; Refsum, H; Sayyad, MG; Schneede, J; Ueland, PM; Ulvik, A; Vollset, SE; Yajnik, CS, 2001) |
| "We report on a female neonate with diabetes mellitus and methylmalonic acidaemia, who died at age 16 days." | 3.68 | Congenital absence of insulin cells in a neonate with diabetes mellitus and mutase-deficient methylmalonic acidaemia. ( Baumgartner, R; Blum, D; De Prez, C; Dorchy, H; Fowler, B; Heimann, P; Kumps, A; Mardens, Y; Mouraux, T; Vamos, E, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solomon, LR | 1 |
| Kwok, T | 1 |
| Lee, J | 1 |
| Ma, RC | 1 |
| Wong, SY | 1 |
| Kung, K | 1 |
| Lam, A | 1 |
| Ho, CS | 1 |
| Lee, V | 1 |
| Harrison, J | 1 |
| Lam, L | 1 |
| Dorchy, H | 2 |
| Blum, D | 1 |
| Mouraux, T | 1 |
| Vamos, E | 1 |
| Mardens, Y | 1 |
| Kumps, A | 1 |
| De Prez, C | 1 |
| Heimann, P | 1 |
| Fowler, B | 1 |
| Baumgartner, R | 1 |
| Refsum, H | 1 |
| Yajnik, CS | 1 |
| Gadkari, M | 1 |
| Schneede, J | 1 |
| Vollset, SE | 1 |
| Orning, L | 1 |
| Guttormsen, AB | 1 |
| Joglekar, A | 1 |
| Sayyad, MG | 1 |
| Ulvik, A | 1 |
| Ueland, PM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02457507] | Phase 4 | 271 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for methylmalonic acid and Diabetes Mellitus
| Article | Year |
|---|---|
A randomized placebo controlled trial of vitamin B
Topics: Aged; Cholesterol; Cognitive Dysfunction; Creatinine; Diabetes Mellitus; Dietary Supplements; Female | 2017 |
4 other studies available for methylmalonic acid and Diabetes Mellitus
| Article | Year |
|---|---|
Functional cobalamin (vitamin B12) deficiency: role of advanced age and disorders associated with increased oxidative stress.
Topics: Aged; Aged, 80 and over; Aging; Alcohol Drinking; Connecticut; Diabetes Mellitus; Dietary Supplement | 2015 |
[Neonatal diabetes mellitus caused by congenital absence of beta cells associated with methylmalonic acidemia due to uniparental disomy of chromosome 6].
Topics: Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 6; Diabetes Mellitus; Humans; | 1995 |
Congenital absence of insulin cells in a neonate with diabetes mellitus and mutase-deficient methylmalonic acidaemia.
Topics: Autopsy; Cytoplasmic Granules; Diabetes Complications; Diabetes Mellitus; Female; Glucagon; Humans; | 1993 |
Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Diet, Vegetarian; Female; Folic Acid; | 2001 |