methylmalonic acid has been researched along with Diabetes Mellitus, Adult-Onset in 8 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Non-insulin-dependent diabetes mellitus (NIDDM) and hyperhomocysteinemia are both associated with premature vascular disease." | 5.09 | Total homocysteine is associated with nephropathy in non-insulin-dependent diabetes mellitus. ( Allen, RH; Cohen, JA; Estacio, R; Jeffers, BW; Schrier, RW; Stabler, SP, 1999) |
| " Metabolic syndrome and polycystic ovary syndrome diagnosed patients with insulin resistance and/or impaired glucose tolerance, patients with type 2 diabetes mellitus (DM) treated with metformin were enrolled in study." | 4.12 | Does Metformin Treatment in Pediatric Population Cause Vitamin B12 Deficiency? ( Berberoglu, M; Dogan, O; Eminoglu, FT; Kontbay, T; Kose, E; Siklar, Z; Taş, Ö; Tumer, L, 2022) |
| "Vitamin B12 deficiency is common in certain populations, such as in India, where there is also a rising prevalence of Type 2 diabetes, obesity and their complications." | 2.50 | The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity. ( Finer, S; Hitman, G; Saravanan, P; Yajnik, C, 2014) |
| "This study included 3,277 adults with type 2 diabetes from the National Health and Nutrition Examination Survey (NHANES) and followed up until 31 December 2015." | 1.72 | Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES. ( Fang, S; Guo, J; Tian, M; Wan, X; Wang, S; Wang, Y; Yu, B; Zhang, Y, 2022) |
| "Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN)." | 1.62 | The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus. ( El-Sherif, M; Esmael, A; Hashem, MM; Nassar, AK, 2021) |
| "Metformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial." | 1.48 | Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial. ( Kooy, A; Lehert, P; Out, M; Schalkwijk, CA; Stehouwer, CDA, 2018) |
| "The 176 Chinese patients with Type 2 diabetes mellitus were divided into 3 groups according to the levels of vitamin B12." | 1.40 | Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes. ( Chen, SH; Li, XB; Liu, XH; Liu, YT; Ni, YH; Sun, AL; Zhuang, XH, 2014) |
| "Diabetic nephropathy is a common complication in patients with type 2 diabetes that may increase atherothrombotic risk." | 1.33 | Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes. ( Fowler, B; Herrmann, W; Kuhlmann, MK; Makowski, J; Obeid, R; Schorr, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, S | 1 |
| Wang, Y | 1 |
| Wan, X | 1 |
| Guo, J | 1 |
| Zhang, Y | 1 |
| Tian, M | 1 |
| Fang, S | 1 |
| Yu, B | 1 |
| Taş, Ö | 1 |
| Kontbay, T | 1 |
| Dogan, O | 1 |
| Kose, E | 1 |
| Berberoglu, M | 1 |
| Siklar, Z | 1 |
| Tumer, L | 1 |
| Eminoglu, FT | 1 |
| Hashem, MM | 1 |
| Esmael, A | 1 |
| Nassar, AK | 1 |
| El-Sherif, M | 1 |
| Out, M | 1 |
| Kooy, A | 1 |
| Lehert, P | 1 |
| Schalkwijk, CA | 1 |
| Stehouwer, CDA | 1 |
| Finer, S | 1 |
| Saravanan, P | 1 |
| Hitman, G | 1 |
| Yajnik, C | 1 |
| Sun, AL | 1 |
| Ni, YH | 1 |
| Li, XB | 1 |
| Zhuang, XH | 1 |
| Liu, YT | 1 |
| Liu, XH | 1 |
| Chen, SH | 1 |
| Herrmann, W | 1 |
| Schorr, H | 1 |
| Obeid, R | 1 |
| Makowski, J | 1 |
| Fowler, B | 1 |
| Kuhlmann, MK | 1 |
| Stabler, SP | 1 |
| Estacio, R | 1 |
| Jeffers, BW | 1 |
| Cohen, JA | 1 |
| Allen, RH | 1 |
| Schrier, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of Metformin HCL in Patients With Type 2 Diabetes Intensively Treated With Insulin: a Treatment Strategy for Insulin Resistance in Type 2 Diabetes Mellitus: a Randomized Controlled Trial[NCT00375388] | Phase 3 | 400 participants | Interventional | 1998-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for methylmalonic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity.
Topics: Adiposity; Carbon Cycle; Diabetes Mellitus, Type 2; Environmental Exposure; Female; Fetal Developmen | 2014 |
1 trial available for methylmalonic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Total homocysteine is associated with nephropathy in non-insulin-dependent diabetes mellitus.
Topics: Adult; Aged; Albuminuria; Cystathionine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; | 1999 |
6 other studies available for methylmalonic acid and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES.
Topics: Adult; Biomarkers; Diabetes Mellitus, Type 2; Humans; Methylmalonic Acid; Nutrition Surveys; Vitamin | 2022 |
Does Metformin Treatment in Pediatric Population Cause Vitamin B12 Deficiency?
Topics: Adolescent; Child; Diabetes Mellitus, Type 2; Female; Homocysteine; Humans; Male; Metabolic Syndrome | 2022 |
The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Homocysteine; Humans; Male; Metformin; Met | 2021 |
Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Male; Metform | 2018 |
Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes.
Topics: Adult; Aged; Asian People; Biomarkers; China; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Fema | 2014 |
Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes.
Topics: Aged; Cystathionine; Cysteine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid | 2005 |