methylmalonic acid has been researched along with Developmental Disabilities in 7 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Developmental Disabilities: Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylmalonic acidaemia (MMA) is a rare autosomal recessive inborn error of metabolism that typically presents in infancy with recurrent episodes of metabolic acidosis, developmental delay and failure to thrive." | 1.33 | Management of methylmalonic acidaemia by combined liver-kidney transplantation. ( Enns, GM; Millan, MT; Nagarajan, S; Sarwal, MM; Winter, S, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strand, TA | 1 |
| Taneja, S | 1 |
| Ueland, PM | 1 |
| Refsum, H | 1 |
| Bahl, R | 1 |
| Schneede, J | 1 |
| Sommerfelt, H | 1 |
| Bhandari, N | 1 |
| Nagarajan, S | 1 |
| Enns, GM | 1 |
| Millan, MT | 1 |
| Winter, S | 1 |
| Sarwal, MM | 1 |
| Mc Guire, PJ | 1 |
| Lim-Melia, E | 1 |
| Diaz, GA | 1 |
| Raymond, K | 1 |
| Larkin, A | 1 |
| Wasserstein, MP | 1 |
| Sansaricq, C | 1 |
| Kosonen, T | 1 |
| Pihko, H | 1 |
| Shevell, MI | 1 |
| Matiaszuk, N | 1 |
| Ledley, FD | 1 |
| Rosenblatt, DS | 1 |
| Roe, CR | 1 |
| Struys, E | 1 |
| Kok, RM | 1 |
| Roe, DS | 1 |
| Harris, RA | 1 |
| Jakobs, C | 1 |
| Smolka, V | 1 |
| Bekárek, V | 1 |
| Hlídková, E | 1 |
| Bucil, J | 1 |
| Mayerová, D | 1 |
| Skopková, Z | 1 |
| Adam, T | 1 |
| Hrubá, E | 1 |
| Kozich, V | 1 |
| Buriánková, L | 1 |
| Saligová, J | 1 |
| Buncová, M | 1 |
| Zeman, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children[NCT00272116] | 2,482 participants (Actual) | Interventional | 1998-02-28 | Completed | |||
| Supplementation of Vitamin B12 in Pregnancy and Postpartum on Growth and Cognitive Functioning in Early Childhood: A Randomized, Placebo Controlled Trial[NCT03071666] | Phase 2/Phase 3 | 800 participants (Actual) | Interventional | 2017-03-27 | Active, not recruiting | ||
| Vitamin B12 Status in Infancy and the Effect of Providing Vitamin B12 to Infants With Signs of Suboptimal Vitamin B12 Status - a Registry-based, Randomized Controlled Trial[NCT05005897] | Phase 2/Phase 3 | 600 participants (Anticipated) | Interventional | 2021-12-08 | Recruiting | ||
| The Effect of Vitamin B12 Supplementation in Nepali Infants on Growth and Development[NCT02272842] | Phase 2/Phase 3 | 600 participants (Actual) | Interventional | 2015-04-20 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Wechsler Preschool and Primary Scale of Intelligence - Fourth Edition. This is a test of general abilities (IQ-test) Expected mean (SD): 100 (15), higher value indicate better cognitive functioning. Range approx. 40-140" (NCT02272842)
Timeframe: 3 years
| Intervention | IQ points (Mean) |
|---|---|
| Vitamin B12 | 84.4 |
| Placebo | 85.0 |
Change in hemoglobin concentration from baseline to end study. (NCT02272842)
Timeframe: 12 months
| Intervention | g/dl (Mean) |
|---|---|
| Vitamin B12 | 1.1 |
| Placebo | 1.0 |
Cognitive, Fine Motor, Gross Motor, Receptive language, and Expressive language scaled scores of the Bayley Scales of Infant Development version 3. This scale measures different aspects of neurodevelopment. The mean (SD) scores are usually 100 (15), and 95% of the population has scores between 70 and 130 (theoretical max/means 0/200). The higher scores, the better neurodevelopment; the scale is normalized on age. (NCT02272842)
Timeframe: 12 months
| Intervention | Scaled Scores (Mean) | ||||
|---|---|---|---|---|---|
| Cognitive | Receptive language | Expressive language | Fine Motor | Gross Motor | |
| Placebo | 8.2 | 8.9 | 8.5 | 10.9 | 9.1 |
| Vitamin B12 | 8.1 | 9.0 | 8.6 | 10.7 | 9.2 |
We will draw a blood sample at study start and at end study to measure to what extent vitamin status is altered. (NCT02272842)
Timeframe: 12 months
| Intervention | mol/L (Mean) | ||
|---|---|---|---|
| Cobalamin | homocysteine' | Methyl Malonic acid | |
| Placebo | 290.1 | 8.2 | .4 |
| Vitamin B12 | 316.3 | 6.6 | 0.3 |
1 review available for methylmalonic acid and Developmental Disabilities
| Article | Year |
|---|---|
Combined liver-kidney transplant for the management of methylmalonic aciduria: a case report and review of the literature.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Developmental Disabilities; Humans; Kidney T | 2008 |
1 trial available for methylmalonic acid and Developmental Disabilities
| Article | Year |
|---|---|
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
5 other studies available for methylmalonic acid and Developmental Disabilities
| Article | Year |
|---|---|
Management of methylmalonic acidaemia by combined liver-kidney transplantation.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Body Mass Index; Body Weight; Child; Developmental | 2005 |
[Development regression in a child caused by vitamin B12 deficiency].
Topics: Adult; Developmental Disabilities; Female; Humans; Infant; Methylmalonic Acid; Vitamin B 12; Vitamin | 1994 |
Varying neurological phenotypes among muto and mut- patients with methylmalonylCoA mutase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Cell Line; Child; Child, Preschool; Developmental Disabilities | 1993 |
Methylmalonic semialdehyde dehydrogenase deficiency: psychomotor delay and methylmalonic aciduria without metabolic decompensation.
Topics: Aldehyde Oxidoreductases; Amino Acid Metabolism, Inborn Errors; Developmental Disabilities; Humans; | 1998 |
[Metabolic complications and neurologic manifestations of vitamin B12 deficiency in children of vegetarian mothers].
Topics: Anemia, Megaloblastic; Brain; Breast Feeding; Developmental Disabilities; Diet, Vegetarian; Failure | 2001 |