methylmalonic acid has been researched along with Dementia in 8 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gastritis was indirectly diagnosed by measuring serum antibodies against H,K-ATPase, HELICOBACTER PYLORI and intrinsic factor, using enzyme-linked immunosorbent assays." | 5.32 | Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia. ( Borch, K; Marcusson, J; Mårdh, E; Mårdh, S; Nägga, K; Rajani, R, 2003) |
| "The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20)." | 5.29 | Serum cobalamin and methylmalonic acid in Alzheimer dementia. ( Christensen, JE; Gulmann, NC; Kristensen, MO; Ostergaard, K; Rasmussen, K, 1993) |
| "Methylmalonic aciduria (MMA-uria) is seen in several inborn errors of metabolism (IEM) affecting intracellular cobalamin pathways." | 3.91 | ( Andréasson, M; Svenningsson, P; von Döbeln, U; Wedell, A; Zetterström, RH, 2019) |
| " The authors summarized dose-response evidence from randomized controlled trials and prospective cohort studies on the relation of vitamin B12 intake and status with cognitive function in adults and elderly people." | 2.49 | Vitamin B12 intake and status and cognitive function in elderly people. ( Brzozowska, A; Cavelaars, AE; de Groot, LC; Dhonukshe-Rutten, RA; Doets, EL; Dullemeijer, C; Souverein, OW; Szczecińska, A; van 't Veer, P; van Wijngaarden, JP, 2013) |
| "Gastritis was indirectly diagnosed by measuring serum antibodies against H,K-ATPase, HELICOBACTER PYLORI and intrinsic factor, using enzyme-linked immunosorbent assays." | 1.32 | Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia. ( Borch, K; Marcusson, J; Mårdh, E; Mårdh, S; Nägga, K; Rajani, R, 2003) |
| "The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20)." | 1.29 | Serum cobalamin and methylmalonic acid in Alzheimer dementia. ( Christensen, JE; Gulmann, NC; Kristensen, MO; Ostergaard, K; Rasmussen, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andréasson, M | 1 |
| Zetterström, RH | 1 |
| von Döbeln, U | 1 |
| Wedell, A | 1 |
| Svenningsson, P | 1 |
| O'Leary, F | 1 |
| Allman-Farinelli, M | 1 |
| Samman, S | 1 |
| Doets, EL | 1 |
| van Wijngaarden, JP | 1 |
| Szczecińska, A | 1 |
| Dullemeijer, C | 1 |
| Souverein, OW | 1 |
| Dhonukshe-Rutten, RA | 1 |
| Cavelaars, AE | 1 |
| van 't Veer, P | 1 |
| Brzozowska, A | 1 |
| de Groot, LC | 1 |
| Nägga, K | 1 |
| Rajani, R | 1 |
| Mårdh, E | 1 |
| Borch, K | 1 |
| Mårdh, S | 1 |
| Marcusson, J | 1 |
| Moretti, R | 1 |
| Torre, P | 1 |
| Antonello, RM | 1 |
| Cattaruzza, T | 1 |
| Cazzato, G | 1 |
| Bava, A | 1 |
| Kristensen, MO | 1 |
| Gulmann, NC | 1 |
| Christensen, JE | 1 |
| Ostergaard, K | 1 |
| Rasmussen, K | 1 |
| Augoustides-Savvopoulou, P | 1 |
| Mylonas, I | 1 |
| Sewell, AC | 1 |
| Rosenblatt, DS | 1 |
| Nilsson, K | 1 |
| Gustafson, L | 1 |
| Hultberg, B | 1 |
3 reviews available for methylmalonic acid and Dementia
| Article | Year |
|---|---|
Vitamin B₁₂ status, cognitive decline and dementia: a systematic review of prospective cohort studies.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition; Cognition Disorders; Cognitive Dysfunction; Dementia | 2012 |
Vitamin B12 intake and status and cognitive function in elderly people.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cognition Disorders; Dementia; Diet; Humans; | 2013 |
Vitamin B12 and folate depletion in cognition: a review.
Topics: Cognition; Cognition Disorders; Dementia; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; M | 2004 |
1 trial available for methylmalonic acid and Dementia
| Article | Year |
|---|---|
The plasma homocysteine concentration is better than that of serum methylmalonic acid as a marker for sociopsychological performance in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Dementia; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; | 2000 |
4 other studies available for methylmalonic acid and Dementia
| Article | Year |
|---|---|
Topics: Aged; Dementia; Humans; Male; Metabolism, Inborn Errors; Methylmalonic Acid; Mutation; Parkinson Dis | 2019 |
Cobalamin, folate, methylmalonic acid, homocysteine, and gastritis markers in dementia.
Topics: Biomarkers; Case-Control Studies; Dementia; Folic Acid; Gastritis; Homocysteine; Humans; Methylmalon | 2003 |
Serum cobalamin and methylmalonic acid in Alzheimer dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Diagnosis, Differential; Erythrocyte In | 1993 |
Reversible dementia in an adolescent with cblC disease: clinical heterogeneity within the same family.
Topics: Aging; Child; Dementia; Electroencephalography; Female; Homocystinuria; Humans; Hydroxocobalamin; Le | 1999 |