methylmalonic acid has been researched along with Deficiency, Vitamin B 12 in 537 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Combined methylmalonic acidemia and homocystinuria, cblC type, is an inborn error of intracellular cobalamin metabolism with a wide spectrum of clinical manifestations that is stated to be the most common inherited disorder of cobalamin metabolism." | 8.88 | Combined methylmalonic acidemia and homocystinuria, cblC type. I. Clinical presentations, diagnosis and management. ( Carrillo-Carrasco, N; Chandler, RJ; Venditti, CP, 2012) |
| "Combined methylmalonic aciduria and homocystinuria (MMA-HC) is a rare metabolic disease characterized by an inborn defect in B12 vitamin metabolism." | 8.86 | Oral and craniofacial findings in a patient with methylmalonic aciduria and homocystinuria: review and a case report. ( D'Alessandro, G; Piana, G; Tagariello, T, 2010) |
| "A hemolytic-uremic syndrome associated with methylmalonic aciduria and homocystinuria is seen during the first weeks of life." | 8.78 | [Neonatal hemolytic-uremic syndrome, methylmalonic aciduria and homocystinuria caused by intracellular vitamin B 12 deficiency. Value of etiological diagnosis]. ( Casadevall, I; Chenel, C; Gourrier, E; Ogier, H; Wood, C; Zittoun, J, 1993) |
| "Associations between pregnancy fasting plasma total homocysteine (tHcy), cobalamin status (plasma cobalamin, holotranscobalamin (holoTC), methylmalonic acid (MMA)) and mid-childhood metabolic score (MetSco) ((including fat mass index (zFMI), homeostatic model assessment of insulin resistance (zHOMA-IR) and dyslipidemia (zTG - zHDLc)/2) z-scores)) were investigated in a prospective study of 293 mother-child dyads." | 8.31 | Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring. ( Ballesteros, M; Cavallé-Busquets, P; Fernandez-Ballart, J; Grifoll, C; Masana, L; Murphy, MM; Ornosa-Martin, G; Ramos-Rodriguez, C; Rojas-Gómez, A; Solé-Navais, P; Ueland, PM, 2023) |
| " CblC deficiency, an inborn error of cobalamin processing, is a rare cause of atypical hemolytic-uremic syndrome (aHUS) and results in hyperhomocysteinemia and methylmalonic aciduria." | 8.12 | The roles of homocysteinemia and methylmalonic acidemia in kidney injury in atypical hemolytic uremic syndrome caused by cobalamin C deficiency. ( Elmaghrabi, A; Gotway, G; Wolf, MTF; Wood, WD, 2022) |
| "We describe 3 patients with short bowel syndrome who had persistently elevated serum methylmalonic acid (MMA) levels while being treated for vitamin B12 deficiency." | 7.88 | Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series. ( Depaula, B; Duggan, CP; Jimenez, L; Stamm, DA, 2018) |
| "Patients with combined methylmalonic acidemia and homocystinuria respond to a combined treatment consisting of supplementation of hydroxycobalamin, betaine, folic acid, vitamin B6 and L-carnitine with clinical and biochemical improvement." | 7.79 | [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. ( Gao, XL; Gu, XF; Han, LS; Huang, Z; Ji, WJ; Li, XY; Qiu, WJ; Wang, Y; Ye, J; Zhang, HW, 2013) |
| "Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration." | 7.78 | Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. ( Brosnan, JT; Brosnan, ME; Lamarre, SG; Molloy, AM; Reinke, SN; Sykes, BD, 2012) |
| "This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group)." | 7.77 | Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study. ( Cuesta, J; Férnandez, C; García-Moll, X; Martí-Fabregas, J; Piñana, JL; Queraltó, JM; Remacha, AF; Rodriguez, A; Sardà, MP; Souto, JC, 2011) |
| "In propionic aciduria and methylmalonic aciduria, hyperammonemia as a symptom of metabolic decompensation is one of the major clinical problems." | 7.76 | N-carbamylglutamate in emergency management of hyperammonemia in neonatal acute onset propionic and methylmalonic aciduria. ( Donati, MA; Filippi, L; Fiorini, P; Gozzini, E; la Marca, G; Malvagia, S, 2010) |
| "We attempted to attribute associations that we previously found between higher folate status and anemia and cognitive test performance to circulating unmetabolized folic acid or 5-methyltetrahydrofolate (5MeTHF)." | 7.76 | Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2010) |
| "To evaluate whether low levels of holotranscobalamin (holoTC) or elevated levels of methylmalonic acid (MMA), both indicators of vitamin B(12) deficiency, might predispose to new cardiovascular events following an acute myocardial infarction (MI)." | 7.74 | Holotranscobalamin and methylmalonic acid as prognostic markers following an acute myocardial infarction. ( Aarsetøy, H; Grundt, H; Mansoor, MA; Nilsen, DW; Reine, A; Valente, E, 2008) |
| " Forty-seven percent of the subjects had cobalamin deficiency (total cobalamin <150 pmol/L), 73% had low holoTC (<35 pmol/L), 77% had hyperhomocysteinemia (tHcy >15 micromol/L), and 73% had elevated serum MMA (>0." | 7.71 | Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. ( Gadkari, M; Guttormsen, AB; Joglekar, A; Orning, L; Refsum, H; Sayyad, MG; Schneede, J; Ueland, PM; Ulvik, A; Vollset, SE; Yajnik, CS, 2001) |
| "Relationship between methylmalonic acid and cobalamin in uremia." | 7.70 | Relationship between methylmalonic acid and cobalamin in uremia. ( Moelby, L; Nielsen, G; Rasmussen, K; Ring, T, 2000) |
| "Subtle cobalamin deficiency states, where low serum cobalamin levels are not accompanied by megaloblastic anemia or malabsorption of free cobalamin, often display metabolic evidence of cellular depletion as shown by the deoxyuridine suppression test." | 7.68 | Reversal by cobalamin therapy of minimal defects in the deoxyuridine suppression test in patients without anemia: further evidence for a subtle metabolic cobalamin deficiency. ( Carmel, R, 1992) |
| "The eyes of a 22-month-old girl with the cobalamin C complementation type of combined methylmalonic aciduria and homocystinuria were studied with light and electron microscopy." | 7.68 | Ocular histopathologic characteristics of cobalamin C type vitamin B12 defect with methylmalonic aciduria and homocystinuria. ( Geraghty, MT; Green, WR; Maumenee, IH; Silva, JC; Traboulsi, EI; Valle, D, 1992) |
| "The use of hydroxocobalamin (OH-B12), betaine, carnitine, and folinic acid were studied in two children with the cobalamin C form of methylmalonic acidemia and homocystinuria." | 7.67 | Therapeutic approaches to cobalamin-C methylmalonic acidemia and homocystinuria. ( Allen, RH; Bartholomew, DW; Batshaw, ML; Francomano, CA; Roe, CR; Rosenblatt, D; Valle, DL, 1988) |
| " He was found to have methylmalonic aciduria (79 mumol per milligram of creatinine) and homocystinuria (0." | 7.66 | A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian. ( Higginbottom, MC; Nyhan, WL; Sweetman, L, 1978) |
| "Hearing loss has been associated with poor vitamin B12 status in some, but not all studies." | 6.72 | Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults. ( Allen, RH; De Chicchis, AR; Johnson, MA; Park, S; Shea-Miller, K; Stabler, SP, 2006) |
| "The full syndrome of a vitamin B12 deficiency is rather simple to diagnose." | 6.39 | [Low serum vitamin B 12 level and vitamin B 12 deficiency in the elderly. When should supplement be provided?]. ( de Rooij, S; Hooijer, C; Thijssen, C; van Bruggen, R, 1994) |
| "Methylmalonic Acidurias (MMAs) are a group of inborn errors of metabolism (IEMs), specifically of propionate catabolism characterized by gastrointestinal and neurometabolic manifestations resulting from a deficiency in the function of methylmalonyl-CoA mutase, methylmalonyl-CoA epimerase, and cobalamin metabolism." | 5.56 | A False-Positive Case of Methylmalonic Aciduria by Tandem Mass Spectrometry Newborn Screening Dependent on Maternal Malnutrition in Pregnancy. ( Brindisino, P; Cicalini, I; Consalvo, A; De Laurenzi, V; Dionisi-Vici, C; Gasparroni, G; Gazzolo, D; Pieragostino, D; Rizzo, C; Rossi, C; Semeraro, D; Valentinuzzi, S; Zucchelli, M, 2020) |
| "To evaluate efficacy of oral or injectable supplementation with cobalamin in normalizing serum cobalamin and methylmalonic acid (MMA) concentrations in dogs with hypocobalaminemia caused by either chronic enteropathy (CE) or exocrine pancreatic insufficiency (EPI)." | 5.51 | Effect of oral or injectable supplementation with cobalamin in dogs with hypocobalaminemia caused by chronic enteropathy or exocrine pancreatic insufficiency. ( Chang, CH; Lidbury, JA; Steiner, JM; Suchodolski, JS, 2022) |
| "The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20)." | 5.29 | Serum cobalamin and methylmalonic acid in Alzheimer dementia. ( Christensen, JE; Gulmann, NC; Kristensen, MO; Ostergaard, K; Rasmussen, K, 1993) |
| "Mandatory fortification of flour with folic acid has reduced the number of neural tube defects in North America." | 5.13 | Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial. ( Brouwer, IA; Clarke, R; Katan, MB; Verhoef, P; Winkels, RM, 2008) |
| "Combined methylmalonic acidemia and homocystinuria, cblC type, is an inborn error of intracellular cobalamin metabolism with a wide spectrum of clinical manifestations that is stated to be the most common inherited disorder of cobalamin metabolism." | 4.88 | Combined methylmalonic acidemia and homocystinuria, cblC type. I. Clinical presentations, diagnosis and management. ( Carrillo-Carrasco, N; Chandler, RJ; Venditti, CP, 2012) |
| "Combined methylmalonic aciduria and homocystinuria (MMA-HC) is a rare metabolic disease characterized by an inborn defect in B12 vitamin metabolism." | 4.86 | Oral and craniofacial findings in a patient with methylmalonic aciduria and homocystinuria: review and a case report. ( D'Alessandro, G; Piana, G; Tagariello, T, 2010) |
| "Although early epidemiologic studies showed a protective effect of adequate maternal folic acid (FA) status against neural tube defects (NTDs), the role of adequate vitamin B-12 nutrition in the putative reduction of NTD frequency has remained uncertain." | 4.85 | Vitamin B-12 and neural tube defects: the Canadian experience. ( Cole, DE; Ray, JG; Thompson, MD, 2009) |
| "An erosive, desquamating dermatitis with histopathologic characteristics resembling acrodermatitis enteropathica may be a presenting sign in cobalamin C methylmalonic acidemia, even in the absence of long-standing nutritional restrictions or deficiency." | 4.79 | Methylmalonic acidemia, cobalamin C type, presenting with cutaneous manifestations. ( Berrios, M; Crawford, D; Frieden, IJ; Goodman, SI; Hart, K; Howard, R; Levy, ML; McCalmont, T; Ohnstad, C; Packman, S; Rosenblatt, DS; Sweetman, L, 1997) |
| "A hemolytic-uremic syndrome associated with methylmalonic aciduria and homocystinuria is seen during the first weeks of life." | 4.78 | [Neonatal hemolytic-uremic syndrome, methylmalonic aciduria and homocystinuria caused by intracellular vitamin B 12 deficiency. Value of etiological diagnosis]. ( Casadevall, I; Chenel, C; Gourrier, E; Ogier, H; Wood, C; Zittoun, J, 1993) |
| "Associations between pregnancy fasting plasma total homocysteine (tHcy), cobalamin status (plasma cobalamin, holotranscobalamin (holoTC), methylmalonic acid (MMA)) and mid-childhood metabolic score (MetSco) ((including fat mass index (zFMI), homeostatic model assessment of insulin resistance (zHOMA-IR) and dyslipidemia (zTG - zHDLc)/2) z-scores)) were investigated in a prospective study of 293 mother-child dyads." | 4.31 | Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring. ( Ballesteros, M; Cavallé-Busquets, P; Fernandez-Ballart, J; Grifoll, C; Masana, L; Murphy, MM; Ornosa-Martin, G; Ramos-Rodriguez, C; Rojas-Gómez, A; Solé-Navais, P; Ueland, PM, 2023) |
| " CblC deficiency, an inborn error of cobalamin processing, is a rare cause of atypical hemolytic-uremic syndrome (aHUS) and results in hyperhomocysteinemia and methylmalonic aciduria." | 4.12 | The roles of homocysteinemia and methylmalonic acidemia in kidney injury in atypical hemolytic uremic syndrome caused by cobalamin C deficiency. ( Elmaghrabi, A; Gotway, G; Wolf, MTF; Wood, WD, 2022) |
| " Metabolic syndrome and polycystic ovary syndrome diagnosed patients with insulin resistance and/or impaired glucose tolerance, patients with type 2 diabetes mellitus (DM) treated with metformin were enrolled in study." | 4.12 | Does Metformin Treatment in Pediatric Population Cause Vitamin B12 Deficiency? ( Berberoglu, M; Dogan, O; Eminoglu, FT; Kontbay, T; Kose, E; Siklar, Z; Taş, Ö; Tumer, L, 2022) |
| "Cobalamin J disease (CblJ) is an ultra-rare autosomal recessive disorder of intracellular cobalamin metabolism associated with combined methylmalonic acidemia and homocystinuria." | 4.02 | Cobalamin J disease detected on newborn screening: Novel variant and normal neurodevelopmental course. ( Aggarwal, A; Berry, SA; Miller, D; Pierpont, EI; Pillai, NR, 2021) |
| "We describe 3 patients with short bowel syndrome who had persistently elevated serum methylmalonic acid (MMA) levels while being treated for vitamin B12 deficiency." | 3.88 | Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series. ( Depaula, B; Duggan, CP; Jimenez, L; Stamm, DA, 2018) |
| "The Cobalamin C deficiency (cblC), characterized with elevated methylmalonic acidemia and homocystinuria in plasma, is an inborn error of cobalamin metabolism." | 3.88 | Late-onset cobalamin C deficiency Chinese sibling patients with neuropsychiatric presentations. ( Liu, YM; Wang, SJ; Yan, CZ; Zhao, YY, 2018) |
| "Patients with combined methylmalonic acidemia and homocystinuria respond to a combined treatment consisting of supplementation of hydroxycobalamin, betaine, folic acid, vitamin B6 and L-carnitine with clinical and biochemical improvement." | 3.79 | [Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment]. ( Gao, XL; Gu, XF; Han, LS; Huang, Z; Ji, WJ; Li, XY; Qiu, WJ; Wang, Y; Ye, J; Zhang, HW, 2013) |
| "Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration." | 3.78 | Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. ( Brosnan, JT; Brosnan, ME; Lamarre, SG; Molloy, AM; Reinke, SN; Sykes, BD, 2012) |
| "A previously healthy 7-week-old boy developed bilateral central retinal artery occlusions in the presence of hyperhomocysteinemia and elevated serum methylmalonic acid and was found to have a transcobalamin receptor mutation." | 3.78 | Bilateral central retinal artery occlusions in an infant with hyperhomocysteinemia. ( Costakos, D; Karth, P; Kim, J; Singh, R, 2012) |
| "This study aimed at assessing the relationship between thrombosis, hyperhomocysteinemia and vitamin B12 deficiency using a case-control study carried out in 326 patients with thrombosis (case group) and 351 patients from the same hospital (control group)." | 3.77 | Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study. ( Cuesta, J; Férnandez, C; García-Moll, X; Martí-Fabregas, J; Piñana, JL; Queraltó, JM; Remacha, AF; Rodriguez, A; Sardà, MP; Souto, JC, 2011) |
| "In propionic aciduria and methylmalonic aciduria, hyperammonemia as a symptom of metabolic decompensation is one of the major clinical problems." | 3.76 | N-carbamylglutamate in emergency management of hyperammonemia in neonatal acute onset propionic and methylmalonic aciduria. ( Donati, MA; Filippi, L; Fiorini, P; Gozzini, E; la Marca, G; Malvagia, S, 2010) |
| "We attempted to attribute associations that we previously found between higher folate status and anemia and cognitive test performance to circulating unmetabolized folic acid or 5-methyltetrahydrofolate (5MeTHF)." | 3.76 | Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2010) |
| "To describe 3 patients with the cblD disorder, a rare inborn error of cobalamin metabolism caused by mutations in the MMADHC gene that can result in isolated homocystinuria, isolated methylmalonic aciduria, or combined homocystinuria and methylmalonic aciduria." | 3.75 | Clinical and molecular heterogeneity in patients with the cblD inborn error of cobalamin metabolism. ( Bernstein, JA; Coelho, D; Cowan, T; Crombez, EA; Enns, GM; Fowler, B; Lee-Messer, C; Miousse, IR; Rosenblatt, DS; Rupar, T; Vilain, E; Watkins, D, 2009) |
| "To explore the dependence of glomerular filtration rate (GFR) on plasma total homocysteine (tHcy) and serum methylmalonic acid (MMA), as well as the consequences for the diagnosis of cobalamin and/or folic acid deficiency in an elderly community-dwelling population." | 3.74 | Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly. ( Lewerin, C; Ljungman, S; Nilsson-Ehle, H, 2007) |
| "To evaluate whether low levels of holotranscobalamin (holoTC) or elevated levels of methylmalonic acid (MMA), both indicators of vitamin B(12) deficiency, might predispose to new cardiovascular events following an acute myocardial infarction (MI)." | 3.74 | Holotranscobalamin and methylmalonic acid as prognostic markers following an acute myocardial infarction. ( Aarsetøy, H; Grundt, H; Mansoor, MA; Nilsen, DW; Reine, A; Valente, E, 2008) |
| " The body weight of the mice fed on a B12-deficient diet for 90 days was slightly lower than that of the control mice administrated CN-B12, and the urinary excretion of methylmalonic acid (MMA) was increased." | 3.72 | Breeding severely vitamin B12-deficient mice as model animals. ( Arai, K; Funada, U; Kawata, T; Kuwamori, M; Maekawa, A; Matsushita, M; Sanai, T; Tadokoro, T; Tanaka, N; Wada, M; Yamada, H; Yamamoto, Y, 2004) |
| "End-stage renal disease (ESRD) is associated with moderately severe hyperhomocysteinemia that is incompletely normalized by oral folic acid therapy and vitamin B12." | 3.72 | Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease. ( Elian, KM; Hoffer, LJ, 2004) |
| " Forty-seven percent of the subjects had cobalamin deficiency (total cobalamin <150 pmol/L), 73% had low holoTC (<35 pmol/L), 77% had hyperhomocysteinemia (tHcy >15 micromol/L), and 73% had elevated serum MMA (>0." | 3.71 | Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. ( Gadkari, M; Guttormsen, AB; Joglekar, A; Orning, L; Refsum, H; Sayyad, MG; Schneede, J; Ueland, PM; Ulvik, A; Vollset, SE; Yajnik, CS, 2001) |
| "A 78-year-old nonvegetarian white woman with symptomatic gastroesophageal reflux (GER) was started on cimetidine 300 mg 4 times daily in February 1990 and took various other antisecretory medications over the course of the next 4 1/2 years." | 3.71 | Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor. ( Page, RL; Ruscin, JM; Valuck, RJ, 2002) |
| "Hyperhomocysteinemia, a well-recognized cardiovascular risk factor, is frequent in hemodialysis (HD) patients." | 3.71 | Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients. ( Funamizu, M; Hata, A; Hayashi, K; Hiejima, Y; Hirayama, H; Kawabata, M; Makita, Y; Nakamura, T; Saionji, K; Tago, K; Tajiri, M; Takano, H, 2002) |
| "To describe epilepsy and EEG findings in the early-onset cobalamin (Cbl) C/D deficiency, an inborn error of intracellular Cbl metabolism characterized by high plasma levels of methylmalonic acid, homocystine, and homocysteine." | 3.71 | Early-onset cobalamin C/D deficiency: epilepsy and electroencephalographic features. ( Biancheri, R; Caruso, U; Cerone, R; Minniti, G; Perrone, MV; Rossi, A; Schiaffino, MC; Tortori-Donati, P; Veneselli, E, 2002) |
| "Relationship between methylmalonic acid and cobalamin in uremia." | 3.70 | Relationship between methylmalonic acid and cobalamin in uremia. ( Moelby, L; Nielsen, G; Rasmussen, K; Ring, T, 2000) |
| "To investigate the relationship between urinary incontinence and Vitamin B12 deficiency in community-living older people using standard serum cobalamin levels as well as the metabolites methylmalonic acid (MMA) and total homocysteine (HCYS)." | 3.70 | Vitamin B12 deficiency and incontinence in older people. ( Freedman, M; Garcia, A; Smith, M, 2000) |
| "To determine the significance of the commonly observed fall in serum vitamin B12 levels during pregnancy, serum levels of the B12 metabolites methylmalonic acid (MMA) and homocysteine (Hcy) were measured in a group of 50 pregnant patients with subnormal serum B12 (range 45-199 pg/ml) and the results compared with those of 25 pregnant controls (serum B12(208-580) pg/ml)." | 3.69 | Biochemical indices of vitamin B12 nutrition in pregnant patients with subnormal serum vitamin B12 levels. ( Bennett, M; Bottiglieri, T; Hyland, K; McGrath, K; Metz, J, 1995) |
| "We compared the sensitivity and specificity of the two metabolite tests, methylmalonic acid (MMA) and total homocysteine (Hcy) in serum, and serum cobalamin (Cbl) in patients referred to our hospital because of suspected cobalamin deficiency and a serum cobalamin value at the referring unit <200 pmol/L." | 3.69 | Serum methylmalonic acid and total homocysteine in patients with suspected cobalamin deficiency: a clinical study based on gastrointestinal histopathological findings. ( Johansson, KW; Kilander, AF; Lindgren, A; Nilsson, O; Swolin, B, 1997) |
| "Subtle cobalamin deficiency states, where low serum cobalamin levels are not accompanied by megaloblastic anemia or malabsorption of free cobalamin, often display metabolic evidence of cellular depletion as shown by the deoxyuridine suppression test." | 3.68 | Reversal by cobalamin therapy of minimal defects in the deoxyuridine suppression test in patients without anemia: further evidence for a subtle metabolic cobalamin deficiency. ( Carmel, R, 1992) |
| "The eyes of a 22-month-old girl with the cobalamin C complementation type of combined methylmalonic aciduria and homocystinuria were studied with light and electron microscopy." | 3.68 | Ocular histopathologic characteristics of cobalamin C type vitamin B12 defect with methylmalonic aciduria and homocystinuria. ( Geraghty, MT; Green, WR; Maumenee, IH; Silva, JC; Traboulsi, EI; Valle, D, 1992) |
| "The use of hydroxocobalamin (OH-B12), betaine, carnitine, and folinic acid were studied in two children with the cobalamin C form of methylmalonic acidemia and homocystinuria." | 3.67 | Therapeutic approaches to cobalamin-C methylmalonic acidemia and homocystinuria. ( Allen, RH; Bartholomew, DW; Batshaw, ML; Francomano, CA; Roe, CR; Rosenblatt, D; Valle, DL, 1988) |
| " Characteristic features in such patients included paresthesia, sensory loss, ataxia, dementia, and psychiatric disorders; longstanding neurologic symptoms without anemia; normal white-cell and platelet counts and serum bilirubin and lactate dehydrogenase levels; and markedly elevated serum concentrations of methylmalonic acid and total homocysteine." | 3.67 | Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. ( Allen, RH; Brust, JC; Garrett, TJ; Healton, EB; Lindenbaum, J; Marcell, PD; Podell, ER; Savage, DG; Stabler, SP, 1988) |
| " He was found to have methylmalonic aciduria (79 mumol per milligram of creatinine) and homocystinuria (0." | 3.66 | A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian. ( Higginbottom, MC; Nyhan, WL; Sweetman, L, 1978) |
| "Investigation of a neonate presenting with a metabolic acidosis, vomiting and an apnoeic attack revealed abnormal urinary excretion of methylmalonic acid (MMA) associated with a low serum vitamin B12." | 3.65 | Neonatal acidosis associated with transient methylmalonicaciduria and vitamin B12 deficiency. ( Ireland, JT; Williams, AJ, 1977) |
| "Hearing loss has been associated with poor vitamin B12 status in some, but not all studies." | 2.72 | Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults. ( Allen, RH; De Chicchis, AR; Johnson, MA; Park, S; Shea-Miller, K; Stabler, SP, 2006) |
| " Little is known about the relative bioavailability of crystalline cobalamin added to food products." | 2.71 | Effect of supplementation with cobalamin carried either by a milk product or a capsule in mildly cobalamin-deficient elderly Dutch persons. ( Blom, HJ; de Groot, LC; Dhonukshe-Rutten, RA; Eussen, SJ; van Staveren, WA; van Zutphen, M, 2005) |
| "Serum MMA, tHcy, and other metabolites at baseline and after each 6-week dosing interval." | 2.70 | Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults. ( Allen, RH; Beresford, SA; Brodkin, KI; Rajan, S; Stabler, SP; Wallace, JI, 2002) |
| "Vitamin B12 deficiency is common in certain populations, such as in India, where there is also a rising prevalence of Type 2 diabetes, obesity and their complications." | 2.50 | The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity. ( Finer, S; Hitman, G; Saravanan, P; Yajnik, C, 2014) |
| " The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence." | 2.49 | Systematic review with dose-response meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned's prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elder ( Cavelaars, AE; de Boer, WJ; de Groot, LC; Dhonukshe-Rutten, RA; Doets, EL; Dullemeijer, C; In 't Veld, PH; Plada, M; Souverein, OW; van 't Veer, P; van der Voet, H; van Wijngaarden, JP, 2013) |
| " We discuss the importance of methylmalonic acid dosage after bariatric surgery in patients who present suspect of cyanocobalamin deficiency with normal values of this vitamin and the role of proton pump inhibitor use and vitamin supplementation in patients with early neurological presentation." | 2.47 | The importance of methylmalonic acid dosage on the assessment of patients with neurological manifestations following bariatric surgery. ( Cosmo, C; Lucena, R; Vieira, C, 2011) |
| "Nearly all patients with vitamin B12 deficiency also have substantially increased levels of methylmalonic acid and homocysteine." | 2.43 | [Diagnosis of vitamin B12 deficiency revised]. ( de Rooij, SE; Fischer, C; Hoekstra, JB; Huijmans, JG; Wiersinga, WJ, 2005) |
| "Diagnosis of vitamin B12 deficiency is typically based on measurement of serum vitamin B12 levels; however, about 50 percent of patients with subclinical disease have normal B12 levels." | 2.42 | Vitamin B12 deficiency. ( Brown, DL; Oh, R, 2003) |
| "The full syndrome of a vitamin B12 deficiency is rather simple to diagnose." | 2.39 | [Low serum vitamin B 12 level and vitamin B 12 deficiency in the elderly. When should supplement be provided?]. ( de Rooij, S; Hooijer, C; Thijssen, C; van Bruggen, R, 1994) |
| "She was eventually diagnosed with subacute combined degeneration because of CblC deficiency and effectively treated." | 1.91 | Pearls & Oy-sters: Late-Onset Cobalamin C Deficiency Presenting With Subacute Combined Degeneration. ( Goyne, C; Kansal, L, 2023) |
| "This study included 3,277 adults with type 2 diabetes from the National Health and Nutrition Examination Survey (NHANES) and followed up until 31 December 2015." | 1.72 | Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES. ( Fang, S; Guo, J; Tian, M; Wan, X; Wang, S; Wang, Y; Yu, B; Zhang, Y, 2022) |
| " She was maintained on 2 mg/kg/day dosing of hydroxocobalamin." | 1.72 | Clinical and biochemical outcomes in cobalamin C deficiency with use of high-dose hydroxocobalamin in the early neonatal period. ( Farach, L; Frigeni, M; Gunther, K; Kacpura, A, 2022) |
| "Intellectual disability was equally distributed among the initial treatment groups, while renal failure (moderate and beginning at the age of 38 years) was present in only one out of seven patients initially treated with B12." | 1.72 | Very long-term outcomes in 23 patients with cblA type methylmalonic acidemia. ( Acquaviva, C; Benoist, JF; Brassier, A; Cano, A; Chabrol, B; De Lonlay, P; Fouilhoux, A; Guffon-Fouilhoux, N; Lachmann, R; Marelli, C; Murphy, E; Pennisi, A; Schiff, M; Servais, A, 2022) |
| "To monitor vitamin B12 deficiency, methylmalonic acid (MMA) is used." | 1.72 | Validation of an automated UPLC-MS/MS method for methylmalonic acid in serum/plasma and its application on clinical samples. ( Bergström, M; Zheng, Y, 2022) |
| "Risk factors for vitamin B12 deficiency in infants are not fully understood." | 1.72 | Nitrous oxide in labour predicted newborn screening total homocysteine and is a potential risk factor for infant vitamin B12 deficiency. ( Bjørke-Monsen, AL; Eklund, EA; Lindberg, M; Ljungblad, UW; Saeves, I; Tangeraas, T, 2022) |
| "The prevalence of vitamin B12 deficiency has not been investigated in Norway." | 1.72 | ( Berg, CL; Mouland, G; Sharikabad, MN; Sommerschild, HT, 2022) |
| "Pregnancy is a state of increased demand and delayed postpartum repletion of nutrients may predispose women to depression." | 1.62 | Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women. ( Bharadwaj, B; Dhiman, P; Pillai, RR; Premkumar, N; Rajendiran, S; Ranjan, VP; Wilson, AB, 2021) |
| "A total of 63." | 1.62 | Maternal vitamin B12 deficiency and perinatal outcomes in southern India. ( Dwarkanath, P; Finkelstein, JL; Fothergill, A; Krisher, JT; Kurpad, AV; Thomas, T, 2021) |
| "Diagnosis of vitamin B12 deficiency is difficult, as there is no conclusive single test for this disorder." | 1.56 | Association of vitamin B12, methylmalonic acid, and functional parameters. ( de Jong, WHA; Huls, G; van der Klauw, MM; Wolffenbuttel, BHR; Wouters, HJCM, 2020) |
| "Methylmalonic Acidurias (MMAs) are a group of inborn errors of metabolism (IEMs), specifically of propionate catabolism characterized by gastrointestinal and neurometabolic manifestations resulting from a deficiency in the function of methylmalonyl-CoA mutase, methylmalonyl-CoA epimerase, and cobalamin metabolism." | 1.56 | A False-Positive Case of Methylmalonic Aciduria by Tandem Mass Spectrometry Newborn Screening Dependent on Maternal Malnutrition in Pregnancy. ( Brindisino, P; Cicalini, I; Consalvo, A; De Laurenzi, V; Dionisi-Vici, C; Gasparroni, G; Gazzolo, D; Pieragostino, D; Rizzo, C; Rossi, C; Semeraro, D; Valentinuzzi, S; Zucchelli, M, 2020) |
| "However, although 24." | 1.56 | Functional vitamin B12 deficiency in phenylketonuria patients and healthy controls: An evaluation with combined indicator of vitamin B12 status as a biochemical index. ( Akış, M; Arslan, N; Işık, İ; İşlekel, H; Kant, M; Kısa, PT; Köse, E, 2020) |
| "In 9 mothers, vitamin B12 deficiency was verified, and 6 showed no indication for vitamin B12 deficiency." | 1.56 | Diagnostic Challenges Using a 2-Tier Strategy for Methylmalonic Acidurias: Data from 1.2 Million Dried Blood Spots. ( Blessing, H; Lotz-Havla, AS; Maier, EM; Röschinger, W; Schiergens, KA; Weiss, KJ, 2020) |
| "Their physical examination showed sensory ataxia." | 1.51 | Isolated subacute combined degeneration in late-onset cobalamin C deficiency in children: Two case reports and literature review. ( Cui, J; Cui, X; Wang, L; Wang, Y; Zhang, H; Zheng, H, 2019) |
| " Finally, amnionless is a novel biomarker which can detect perturbed vitamin B12 bioavailability during aging and physical frailty." | 1.48 | Vitamin B12 deficiency and impaired expression of amnionless during aging. ( Bosco, N; De Castro, A; Feige, JN; Goulet, L; Karaz, S; Larbi, A; Michaud, J; Migliavacca, E; Ng, TP; Pannérec, A; Rezzi, S, 2018) |
| "Metformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial." | 1.48 | Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial. ( Kooy, A; Lehert, P; Out, M; Schalkwijk, CA; Stehouwer, CDA, 2018) |
| "Methylmalonic acid (MMA) is a sensitive indicator of B12 status." | 1.46 | South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women. ( Green, TJ; Isman, C; Jeruszka-Bielak, M; Lamers, Y; Li, W; Schroder, TH, 2017) |
| "Vegetarians have Vitamin B12 deficiency and are more prone to developing neuropsychiatric and neurological problems." | 1.46 | Neuropsychiatric and neurological problems among Vitamin B12 deficient young vegetarians. ( Baig, M; Kapoor, A; Karmani, H; Memon, AS; Tunio, SA, 2017) |
| "Screening average-risk adults for vitamin B12 deficiency is not recommended." | 1.46 | Vitamin B12 Deficiency: Recognition and Management. ( Goodbred, AJ; Langan, RC, 2017) |
| "A total of 66 Crohn's disease (CD) and 30 ulcerative colitis (UC) patients were recruited." | 1.46 | Vitamin B12 deficiency in inflammatory bowel disease: a prospective observational pilot study. ( Afif, W; Battat, R; Bessissow, T; Bitton, A; Byer, J; Dionne, S; Kopylov, U; Nedjar, H; Rahme, E; Seidman, E; Sewitch, MJ; Waters, PJ; Zelikovic, E, 2017) |
| "In 11 of 99 (11%) patients, vitamin B12 deficiency was detected." | 1.46 | Vitamin B12 deficiency after esophagectomy with gastric tube reconstruction for esophageal cancer. ( de Jonge, R; Hötte, GJ; Lindemans, J; van Berge Henegouwen, MI; van der Stok, EP; van Hagen, P; van Lanschot, JJB; Wijnhoven, BPL, 2017) |
| "The diagnosis of subacute combined degeneration of spinal cord was confirmed by an elevated methylmalonic acid, and hyperhomocysteinemia." | 1.46 | Rapid healing of a patient with dramatic subacute combined degeneration of spinal cord: a case report. ( Roessler, FC; Wolff, S, 2017) |
| "Neuropathies often accompany vitamin B12 deficiency." | 1.43 | Vitamin B12-responsive neuropathies: A case series. ( Solomon, LR, 2016) |
| "Vitamin B12 deficiency is common after bariatric surgery." | 1.43 | Improving Bariatric Patient Aftercare Outcome by Improved Detection of a Functional Vitamin B12 Deficiency. ( Boer, AK; Nienhuijs, SW; Said, M; Smelt, HJ; Smulders, JF, 2016) |
| "Since both cancer and neurotoxic antineoplastic agents increase oxidative stress, a role for functional B12 deficiency in CIPN was considered." | 1.43 | Functional vitamin B12 deficiency in advanced malignancy: implications for the management of neuropathy and neuropathic pain. ( Solomon, LR, 2016) |
| "Myeloproliferative disorders are characterized by proliferation of 1 or more lineage of hematologic cells." | 1.42 | Diagnosis of vitamin B12 deficiency in patients with myeloproliferative disorders. ( Aydemir, B; Çekdemir, D; Cinemre, H; Serinkan Cinemre, BF; Tamer, A; Yazar, H, 2015) |
| "Vitamin B12 deficiency is common in patients with CD." | 1.42 | Prevalence and Risk Factors for Functional Vitamin B12 Deficiency in Patients with Crohn's Disease. ( Anderson, SH; Griffin, N; Harrington, DJ; Irving, PM; Kariyawasam, VC; Mogan, SB; Pantelidou, M; Patel, KV; Porté, F; Sanderson, JD; Sobczyńska-Malefora, A; Ward, MG, 2015) |
| "Forty patients with vitamin B12 deficiency and 40 healthy controls were included in the study." | 1.42 | Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency. ( Akinci, S; Alişik, M; Dilek, I; Erel, O; Güney, T; Neşelioğlu, S, 2015) |
| "Malignant hypertension was diagnosed." | 1.40 | Adult-onset eculizumab-resistant hemolytic uremic syndrome associated with cobalamin C deficiency. ( Benoist, JF; Cornec-Le Gall, E; De Parscau, L; Delmas, Y; Doucet, L; Fremeaux-Bacchi, V; Le Meur, Y; Ogier, H, 2014) |
| "The 176 Chinese patients with Type 2 diabetes mellitus were divided into 3 groups according to the levels of vitamin B12." | 1.40 | Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes. ( Chen, SH; Li, XB; Liu, XH; Liu, YT; Ni, YH; Sun, AL; Zhuang, XH, 2014) |
| "The reported clinical cases of vitamin B12 deficiency were found in exclusively breast-fed infants whose asymptomatic mothers were diagnosed later with pernicious anaemia." | 1.40 | Don't forget methylmalonic acid quantification in symptomatic exclusively breast-fed infants. ( Corne, C; Faure, P; Nguyen-Morel, MA; Van Noolen, L, 2014) |
| "Methylmalonic acid (MMA) is a sensitive and specific functional biomarker of vitamin B-12 status, commonly assessed in plasma or serum." | 1.40 | Methylmalonic acid quantified in dried blood spots provides a precise, valid, and stable measure of functional vitamin B-12 status in healthy women. ( Lamers, Y; Quay, TA; Schroder, TH, 2014) |
| "Prevalence of vitamin B12 deficiency in the Indian population is not known, however; it is considered to be higher than in the Western population." | 1.39 | Plasma vitamin B12, methylmalonic acid and heart rate variability in healthy young Indian adults. ( Kurpad, AV; Sowmya, S; Sucharita, S; Thomas, T; Vaz, M, 2013) |
| "Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance." | 1.39 | Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. ( Bjelland, I; Drevon, CA; Engedal, K; Nurk, E; Nygaard, HA; Refsum, H; Smith, DA; Tell, GS; Ueland, PM; Vollset, SE, 2013) |
| "Testing for vitamin B12 deficiency should start with holotranscobalamin measurement." | 1.39 | Utility and limitations of biochemical markers of vitamin B12 deficiency. ( Herrmann, W; Obeid, R, 2013) |
| "A new approach to diagnosing vitamin B12 deficiency is presented, based upon these 2 case descriptions." | 1.38 | [Approaches to vitamin B12 deficiency]. ( Heil, SG; Lindemans, J; Russcher, H; Slobbe, L, 2012) |
| " The increase in the dosage of this gene results in an altered profile of metabolites involved in the folate pathway, including reduced homocysteine (Hcy), methionine, S-adenosylhomocysteine (SAH) and S-adenosylmethionine (SAM)." | 1.38 | Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome. ( Biselli, JM; Carvalho, VM; Eberlin, MN; Fonseca, MF; Goloni-Bertollo, EM; Haddad, R; Pavarino, EC; Vannucchi, H; Zampieri, BL, 2012) |
| "Methylmalonic acid (MMA) level was used as an indicator of vitamin B12 status." | 1.37 | Parenteral vitamin B12 in macrocytic hemodialysis patients reduced MMA levels but did not change mean red cell volume or hemoglobin. ( Jastrzebski, J; Li, G; Martyn, A; Shalansky, K; Snyder, F; Su, VC; Yeung, CK; Zalunardo, N, 2011) |
| "Methylmalonic acid (MMA) is a metabolic intermediate transformed to succinic acid (SA) by a vitamin B(12)-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status." | 1.37 | Methylmalonic acid quantification in low serum volumes by UPLC-MS/MS. ( Allen, LH; Keyes, WR; Newman, JW; Pedersen, TL; Shahab-Ferdows, S, 2011) |
| "In Denmark, patients with vitamin B12 deficiency are usually treated for life with either Betolvex or Vibeden given as injections every third month." | 1.37 | [Treatment response in vitamin B12 deficiency depends on the chosen vitamin B12 preparation]. ( Arendt, J; Nexø, E, 2011) |
| "Methylmalonic acid (MMA) was measured by LC coupled to tandem MS." | 1.36 | High frequency of vitamin B12 deficiency in a Brazilian population. ( Annichino-Bizzacchi, JM; Costa, FF; Saad, ST; Xavier, JM, 2010) |
| "The patient had progressive, severe leukoencephalopathy on multiple MRI scans over 5 years." | 1.36 | Vitamin B12-responsive severe leukoencephalopathy and autonomic dysfunction in a patient with "normal" serum B12 levels. ( Graber, JJ; Kaufmann, H; Kolodny, EH; Sathe, S; Sherman, FT, 2010) |
| "Thereby, the underlying pernicious anemia was masked." | 1.35 | [Thromboembolic events, abortions and a sick infant--unusual presentation of a vitamin deficiency]. ( Driever, PH; Hennermann, JB; Massenkeil, G; Sturm, I; von Arnim-Baas, A, 2008) |
| "Previous reports on pernicious anemia treatment suggested that high folic acid intake adversely influences the natural history of vitamin B-12 deficiency, which affects many elderly individuals." | 1.35 | Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2009) |
| "Lambs with concentrations of vitamin B12 in plasma and liver in the marginal reference range were able to metabolise propionate and maintain normal concentrations of MMA in plasma at a rate of absorption of propionate close to that which would depress appetite." | 1.35 | Vitamin B12 absorption and metabolism in milk-fed lambs. ( Furlong, JM; Gruner, TM; Sedcole, JR; Sykes, AR, 2009) |
| "Autoimmune pernicious anemia was identified in 6 (50%) of 12 Cbl-deficient patients with normal serum Cbl levels." | 1.32 | Challenges in the identification of cobalamin-deficiency polyneuropathy. ( Barohn, RJ; Bryan, WW; Gronseth, GS; Herbelin, LL; Nations, SP; Saperstein, DS; Wolfe, GI, 2003) |
| "HoloTC was the earliest marker for vitamin B12 deficiency followed by MMA." | 1.32 | Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk. ( Geisel, J; Herrmann, W; Obeid, R; Schorr, H, 2003) |
| " The relationship between Cbl supplement dosage and the biochemical parameters was dose dependent." | 1.31 | Is low-dose oral cobalamin enough to normalize cobalamin function in older people? ( Day, A; Evans, L; Freedman, M; Garcia, A; Paris-Pombo, A, 2002) |
| " Increasing the dosage of hydroxycobalamin from 1 to 2." | 1.31 | Cobalamin disorder Cbl-C presenting with late-onset thrombotic microangiopathy. ( Arnout, J; Baumgartner, ER; Fowler, B; Fryns, JP; Grünewald, S; Peters, H; Van Damme, B; Van Damme-Lombaerts, R; Van Hove, JL; Wevers, R, 2002) |
| "Methylmalonic acid was measured by mass spectrometry and homocysteine by HPLC." | 1.31 | Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to vitamin B12 deficiency. ( Allen, RH; Barbé, FM; Droesch, S; Gaire, D; Lambert, DA; Nicolas, JP; Sponne, IE; Stabler, SP, 2000) |
| "In the great majority of cases vitamin B12 deficiency is caused by chronic atrophic gastritis." | 1.31 | [Evaluation of analytic test methods. Stomach-intestines status is the best diagnostic method in suspected vitamin B12 deficiency]. ( Lindgren, A, 2000) |
| "Mental retardation was identified in most of the cases." | 1.31 | Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases. ( Biancheri, R; Caruso, U; Cerone, R; Gatti, R; Perrone, MV; Rossi, A; Schiaffino, MC; Veneselli, E, 2001) |
| "To clarify the bioavailability of vitamin B12 in lyophylized purple laver (nori; Porphyra yezoensis), total vitamin B12 and vitamin B12 analogue contents in the laver were determined, and the effects of feeding the laver to vitamin B12-deficient rats were investigated." | 1.31 | Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status. ( Abe, K; Ebara, S; Miyamoto, E; Nakano, Y; Sugiyama, S; Takenaka, S; Tamura, Y; Tsuyama, S; Watanabe, F, 2001) |
| "The diagnosis and management of vitamin B12 deficiency varies between countries and within countries." | 1.31 | Shifts in B12 opinions in primary health care of Sweden. ( Hultdin, J; Lökk, J; Nilsson, M; Norberg, B; Sandström, H; Westman, G, 2001) |
| "Vitamin B12 deficiency is common, with most patients lacking classic features of advanced severe deficiency." | 1.31 | Reversible myelopathy in a 34-year-old man with vitamin B12 deficiency. ( Harper, CM; Payne, TA; Pittock, SJ, 2002) |
| "Vitamin B12 deficiency is neither correlated with the time elapsed since surgery, nor with the ileum length." | 1.31 | Vitamin B12 and folate after 5-12 years of continent ileal urostomy (Kock reservoir) in children and adolescents. ( Abd-el-Gawa, G; Abrahamsson, K; Hanson, E; Hjälmås, K; Norlén, L, 2002) |
| "Evaluation for the diagnosis of Alzheimer's disease, routine laboratory tests, serum folate and vitamin B-12, serum methylmalonic acid (MMA), total homocysteine (tHcy), and radiological tests was performed in 52 patients with Alzheimer's disease (AD), 50 nondemented hospitalized controls, and 49 healthy elderly subjects living at home." | 1.30 | Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? ( Dejaeger, E; Dereymaeker, L; Ghekiere, V; Joosten, E; Lesaffre, E; Pelemans, W; Riezler, R, 1997) |
| "Thus, there were no metabolic signs of vitamin B12 deficiency in these subjects on parenteral nutrition, despite the fact that their plasma vitamin B12 levels were low." | 1.30 | Home parenteral nutrition and vitamin B12 status. ( Adjalla, C; Beliah, M; Benhayoun, S; Gélot, MA; Guéant, JL; Lambert, D; Messing, B; Nicolas, JP; Thuillier, F, 1997) |
| " The dosage of these two substances help to differenciate between both carencies, but it is not determinant of any of them and is an expensive method." | 1.30 | [Megaloblastic anemia: rapid and economical study]. ( Cicchetti, G; Marín, GH; Tentoni, J, 1997) |
| "Atrophic gastritis was found in 32." | 1.30 | Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. ( Biemond, I; Blom, HJ; de Groot, LC; Hoefnagels, WH; van Asselt, DZ; van Staveren, WA; Wevers, RA, 1998) |
| "To examine the effect of vitamin B12 deficiency on older veterans and its relationship to general health and cognitive impairment." | 1.30 | The effect of vitamin B12 deficiency on older veterans and its relationship to health. ( Bernard, MA; Kashner, TM; Nakonezny, PA, 1998) |
| "Number of patients with gastric body atrophy identified with the combination of MMA and Hcy, and pepsinogen A combined with pepsinogen C or gastrin." | 1.30 | Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery. ( Kilander, AF; Lindgren, A; Lindstedt, G, 1998) |
| "Neurological dysfunction due to vitamin B12 deficiency is most prominent in patients with mild to moderate anaemia." | 1.29 | Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe. ( Bennie, A; Gangaidzo, I; Gwanzura, C; Kiire, C; Lindenbaum, J; Moyo, A; Mudenge, B; Mukiibi, JM; Savage, D; Sitima, J, 1994) |
| "Methylmalonic acid was measured as tert." | 1.29 | Quantification of methylmalonic acid in serum measured by capillary gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives. ( Belleville, F; Dousset, B; Felden, F; Gueant, JL; Straczek, J, 1993) |
| "Methylmalonic acid was elevated in 12." | 1.29 | Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. ( Allen, RH; Lindenbaum, J; Savage, DG; Stabler, SP, 1994) |
| "The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20)." | 1.29 | Serum cobalamin and methylmalonic acid in Alzheimer dementia. ( Christensen, JE; Gulmann, NC; Kristensen, MO; Ostergaard, K; Rasmussen, K, 1993) |
| "Animals are known to convert inorganic selenium to less toxic methylated compounds such as dimethylselenide (DMSe) and trimethylselenonium (TMSe)." | 1.29 | Effect of vitamin B12 status on selenium methylation and toxicity in rats: in vivo and in vitro studies. ( Chen, CL; Whanger, PD, 1993) |
| "To determine the prevalence of vitamin B12 deficiency in patients who have had gastric surgery." | 1.29 | Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin B12 deficiency after gastric surgery. ( Abrahm, JL; Allen, RH; Berry, GT; Chin, MM; Gracely, EJ; Stabler, SP; Sumner, AE, 1996) |
| "Carnitine metabolism was studied in the vitamin B-12-deficient rat to define the relationship between alterations in acylcarnitine generation and the development of methylmalonic aciduria." | 1.27 | Carnitine metabolism in the vitamin B-12-deficient rat. ( Brass, EP; Stabler, SP, 1988) |
| "Vitamin B12 deficiency is a frequently considered diagnosis for which there is no single, commonly available and accurate test." | 1.27 | Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation. ( Feussner, JR; Gale, D; Matchar, DB; Millington, DS; Watson, DJ; Wilkinson, RH, 1987) |
| "Some patients with pernicious anemia who were intermittently treated with cyanocobalamin were found to have elevated serum levels of methylmalonic acid while free of hematologic and neurologic abnormalities." | 1.27 | Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry. ( Allen, RH; Lindenbaum, J; Marcell, PD; Podell, ER; Stabler, SP, 1986) |
| "Methylmalonic acid was assayed by converting it to propionate by heat decarboxylation and then measuring the propionate increment over the endogenous amount in the noncarboxylated sample." | 1.26 | Applicability of an enzymatic quantitation of methylmalonic, propionic, and acetic acids in normal and megaloblastic states. ( Frenkel, EP; Kitchens, RL, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (11.73) | 18.7374 |
| 1990's | 123 (22.91) | 18.2507 |
| 2000's | 149 (27.75) | 29.6817 |
| 2010's | 151 (28.12) | 24.3611 |
| 2020's | 51 (9.50) | 2.80 |
| Authors | Studies |
|---|---|
| Warendorf, JK | 1 |
| van Doormaal, PTC | 1 |
| Vrancken, AFJE | 1 |
| Verhoeven-Duif, NM | 1 |
| van Eijk, RPA | 1 |
| van den Berg, LH | 1 |
| Notermans, NC | 1 |
| Wood, WD | 1 |
| Elmaghrabi, A | 1 |
| Gotway, G | 1 |
| Wolf, MTF | 1 |
| Wang, S | 4 |
| Wang, Y | 4 |
| Wan, X | 1 |
| Guo, J | 2 |
| Zhang, Y | 3 |
| Tian, M | 1 |
| Fang, S | 3 |
| Yu, B | 3 |
| Sluyts, Y | 1 |
| Vanherpe, P | 1 |
| Amir, R | 1 |
| Vanhoenacker, F | 1 |
| Vermeersch, P | 2 |
| Abildgaard, A | 1 |
| Knudsen, CS | 1 |
| Hoejskov, CS | 1 |
| Greibe, E | 1 |
| Parkner, T | 1 |
| Grzych, G | 2 |
| Gernez, E | 2 |
| Deheul, S | 2 |
| Kim, I | 2 |
| Nguyen, MG | 1 |
| Tronick, L | 1 |
| Modirian, F | 1 |
| Mardach, R | 1 |
| Besterman, AD | 1 |
| Taş, Ö | 1 |
| Kontbay, T | 1 |
| Dogan, O | 1 |
| Kose, E | 2 |
| Berberoglu, M | 1 |
| Siklar, Z | 1 |
| Tumer, L | 1 |
| Eminoglu, FT | 1 |
| Kacpura, A | 1 |
| Frigeni, M | 1 |
| Gunther, K | 1 |
| Farach, L | 1 |
| Ailliet, S | 1 |
| Vandenberghe, R | 1 |
| Schiemsky, T | 1 |
| Van Overbeke, L | 1 |
| Demaerel, P | 1 |
| Meersseman, W | 1 |
| Cassiman, D | 1 |
| Samson, ME | 1 |
| Yeung, LF | 1 |
| Rose, CE | 1 |
| Qi, YP | 1 |
| Taylor, CA | 1 |
| Crider, KS | 1 |
| Marelli, C | 1 |
| Fouilhoux, A | 1 |
| Benoist, JF | 2 |
| De Lonlay, P | 1 |
| Guffon-Fouilhoux, N | 1 |
| Brassier, A | 1 |
| Cano, A | 1 |
| Chabrol, B | 1 |
| Pennisi, A | 1 |
| Schiff, M | 1 |
| Acquaviva, C | 1 |
| Murphy, E | 1 |
| Servais, A | 1 |
| Lachmann, R | 1 |
| Zheng, Y | 1 |
| Bergström, M | 1 |
| Rojas-Gómez, A | 1 |
| Solé-Navais, P | 1 |
| Cavallé-Busquets, P | 1 |
| Ornosa-Martin, G | 1 |
| Grifoll, C | 1 |
| Ramos-Rodriguez, C | 1 |
| Fernandez-Ballart, J | 1 |
| Masana, L | 1 |
| Ballesteros, M | 1 |
| Ueland, PM | 32 |
| Murphy, MM | 1 |
| Liu, Y | 3 |
| Zhang, X | 1 |
| Cai, H | 1 |
| Liu, J | 1 |
| Marsden, P | 1 |
| Sharma, AA | 1 |
| Rotella, JA | 1 |
| Wiedemann, A | 1 |
| Oussalah, A | 2 |
| Lamireau, N | 1 |
| Théron, M | 1 |
| Julien, M | 1 |
| Mergnac, JP | 1 |
| Augay, B | 1 |
| Deniaud, P | 1 |
| Alix, T | 1 |
| Frayssinoux, M | 1 |
| Feillet, F | 1 |
| Guéant, JL | 7 |
| Ljungblad, UW | 1 |
| Lindberg, M | 1 |
| Eklund, EA | 1 |
| Saeves, I | 1 |
| Bjørke-Monsen, AL | 3 |
| Tangeraas, T | 1 |
| Chang, CH | 1 |
| Lidbury, JA | 2 |
| Suchodolski, JS | 6 |
| Steiner, JM | 7 |
| Mouland, G | 1 |
| Berg, CL | 1 |
| Sharikabad, MN | 1 |
| Sommerschild, HT | 1 |
| Lipari Pinto, P | 1 |
| Florindo, C | 1 |
| Janeiro, P | 1 |
| Santos, RL | 1 |
| Mexia, S | 1 |
| Rocha, H | 1 |
| Tavares de Almeida, I | 1 |
| Vilarinho, L | 1 |
| Gaspar, A | 1 |
| Goyne, C | 1 |
| Kansal, L | 1 |
| Song, MY | 1 |
| Huang, XL | 1 |
| Wang, F | 2 |
| Zhang, M | 2 |
| Mi, LL | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study of Vitamin B12 Status in Children With Infantile Tremor Syndrome and Pre Infantile Tremor Syndrome[NCT02762682] | 93 participants (Actual) | Observational | 2015-07-31 | Completed | |||
| Micronutrient Status in Pregnant and Lactating Women and Their Infants[NCT03272022] | 272 participants (Actual) | Observational | 2011-12-14 | Completed | |||
| Influence of Vitamins Status on Severe Obesity Related Complications[NCT02663388] | 20,000 participants (Anticipated) | Observational [Patient Registry] | 2016-01-31 | Recruiting | |||
| Study of Metformin HCL in Patients With Type 2 Diabetes Intensively Treated With Insulin: a Treatment Strategy for Insulin Resistance in Type 2 Diabetes Mellitus: a Randomized Controlled Trial[NCT00375388] | Phase 3 | 400 participants | Interventional | 1998-01-31 | Completed | ||
| Cobalamin Status in Young Children With Gastrointestinal Symptoms or Feeding Problems[NCT00710359] | 100 participants (Anticipated) | Interventional | 2008-04-30 | Completed | |||
| Supplementation of Vitamin B12 in Pregnancy and Postpartum on Growth and Cognitive Functioning in Early Childhood: A Randomized, Placebo Controlled Trial[NCT03071666] | Phase 2/Phase 3 | 800 participants (Actual) | Interventional | 2017-03-27 | Active, not recruiting | ||
| Cobalamin Status in Young Children With Developmental Delay and Regression[NCT00710138] | 100 participants (Anticipated) | Interventional | 2008-06-30 | Completed | |||
| Vitamin B12 Status in Infancy and the Effect of Providing Vitamin B12 to Infants With Signs of Suboptimal Vitamin B12 Status - a Registry-based, Randomized Controlled Trial[NCT05005897] | Phase 2/Phase 3 | 600 participants (Anticipated) | Interventional | 2021-12-08 | Recruiting | ||
| B VITAMIN STATUS IN PREMATURE AND SMALL FOR GESTATIONAL AGE INFANTS[NCT01201005] | 80 participants (Actual) | Interventional | 2009-07-31 | Completed | |||
| [NCT02244684] | 368 participants (Actual) | Observational | 2010-09-30 | Completed | |||
| The Bread Trial: a Demonstration Trial to Show Effects of Fortification of Food With Both Folic Acid and Vitamin B12[NCT00353353] | 150 participants (Anticipated) | Interventional | 2006-07-31 | Completed | |||
| Phase 2, Double-Blind, Placebo Controlled Clinical Trial of EPI-743 in Subjects With Cobalamin C Defect[NCT01793090] | Phase 2 | 30 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| How Many Patients Are in Need of Vitamin B12 Injections?[NCT00326833] | Phase 4 | 50 participants (Anticipated) | Interventional | 2006-01-31 | Active, not recruiting | ||
| Assessment of Functional Vitamin B12 Deficiency in Mexican Women[NCT00826657] | 180 participants (Actual) | Interventional | 2004-10-31 | Completed | |||
| Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children[NCT00272116] | 2,482 participants (Actual) | Interventional | 1998-02-28 | Completed | |||
| The Effect of Vitamin B12 Supplementation in Nepali Infants on Growth and Development[NCT02272842] | Phase 2/Phase 3 | 600 participants (Actual) | Interventional | 2015-04-20 | Active, not recruiting | ||
| Effect of Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy[NCT00699478] | Phase 2 | 30 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Cross-sectional Study of the Association of Muscle Strength, Tinetti Test (POMA) Scores and Other Predictor Variables With Serum Vitamin Levels (Vitamin B12, Vitamin D and Folate) in Elderly Patients With Type 2 Diabetes Mellitus[NCT03376490] | 56 participants (Actual) | Observational | 2012-01-01 | Completed | |||
| Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections in Young Indian Children[NCT00717730] | Phase 2 | 1,000 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| The Bioavailability of Vitamin B12 From Nori in Vegetarians: a Dose Response Study[NCT05614960] | 30 participants (Actual) | Interventional | 2022-11-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Wechsler Preschool and Primary Scale of Intelligence - Fourth Edition. This is a test of general abilities (IQ-test) Expected mean (SD): 100 (15), higher value indicate better cognitive functioning. Range approx. 40-140" (NCT02272842)
Timeframe: 3 years
| Intervention | IQ points (Mean) |
|---|---|
| Vitamin B12 | 84.4 |
| Placebo | 85.0 |
Change in hemoglobin concentration from baseline to end study. (NCT02272842)
Timeframe: 12 months
| Intervention | g/dl (Mean) |
|---|---|
| Vitamin B12 | 1.1 |
| Placebo | 1.0 |
Cognitive, Fine Motor, Gross Motor, Receptive language, and Expressive language scaled scores of the Bayley Scales of Infant Development version 3. This scale measures different aspects of neurodevelopment. The mean (SD) scores are usually 100 (15), and 95% of the population has scores between 70 and 130 (theoretical max/means 0/200). The higher scores, the better neurodevelopment; the scale is normalized on age. (NCT02272842)
Timeframe: 12 months
| Intervention | Scaled Scores (Mean) | ||||
|---|---|---|---|---|---|
| Cognitive | Receptive language | Expressive language | Fine Motor | Gross Motor | |
| Placebo | 8.2 | 8.9 | 8.5 | 10.9 | 9.1 |
| Vitamin B12 | 8.1 | 9.0 | 8.6 | 10.7 | 9.2 |
We will draw a blood sample at study start and at end study to measure to what extent vitamin status is altered. (NCT02272842)
Timeframe: 12 months
| Intervention | mol/L (Mean) | ||
|---|---|---|---|
| Cobalamin | homocysteine' | Methyl Malonic acid | |
| Placebo | 290.1 | 8.2 | .4 |
| Vitamin B12 | 316.3 | 6.6 | 0.3 |
68 reviews available for methylmalonic acid and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Neurodevelopmental and neuropsychiatric disorders in cobalamin C disease: a case report and review of the literature.
Topics: Amino Acid Metabolism, Inborn Errors; Autism Spectrum Disorder; Carrier Proteins; Homocystinuria; Hu | 2022 |
The Regulation and Characterization of Mitochondrial-Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice.
Topics: Amino Acid Metabolism, Inborn Errors; Humans; Methylmalonic Acid; Mitochondria; Oxidative Stress; Vi | 2022 |
Review article: Clinical manifestations and outcomes of chronic nitrous oxide misuse: A systematic review.
Topics: Homocysteine; Humans; Methylmalonic Acid; Nitrous Oxide; Prospective Studies; Vitamin B 12; Vitamin | 2022 |
Clinical, phenotypic and genetic landscape of case reports with genetically proven inherited disorders of vitamin B
Topics: Humans; Methylmalonic Acid; Muscle Hypotonia; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins | 2022 |
Vitamin B
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Child; Child, Preschool; Female; Homocystein | 2017 |
Association of
Topics: Adult; Aged; Alleles; Alzheimer Disease; Carbon; Child; Congenital Abnormalities; Female; Genotype; | 2017 |
Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B-12 Deficiency: Clinical Implications.
Topics: Histamine H2 Antagonists; Homocysteine; Humans; Metformin; Methylmalonic Acid; Nutritional Status; P | 2018 |
The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity.
Topics: Adiposity; Carbon Cycle; Diabetes Mellitus, Type 2; Environmental Exposure; Female; Fetal Developmen | 2014 |
Vitamin B12 deficiency.
Topics: Homocysteine; Humans; Hydroxocobalamin; Methylmalonic Acid; Transcobalamins; Vitamin B 12; Vitamin B | 2014 |
Advances in mechanisms, diagnosis, and treatment of pernicious anemia.
Topics: Aged; Algorithms; Anemia, Pernicious; Autoimmune Diseases; Decision Support Systems, Clinical; Dieta | 2015 |
Topics: Algorithms; Diagnosis, Differential; Folic Acid; Folic Acid Deficiency; Guideline Adherence; Humans; | 2016 |
The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status.
Topics: Biomarkers; Erythrocytes; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; | 2008 |
Vitamin B-12 and cognition in the elderly.
Topics: Aged; Aging; Biomarkers; Cognition Disorders; Female; Humans; Male; Methylmalonic Acid; Nutritional | 2009 |
Vitamin B-12 and neural tube defects: the Canadian experience.
Topics: Adult; Biological Availability; Biomarkers; Canada; Female; Flour; Folic Acid; Food, Fortified; Huma | 2009 |
Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials.
Topics: Biomarkers; Dietary Supplements; Homocysteine; Humans; Methylmalonic Acid; Nutrition Assessment; Nut | 2009 |
Oral and craniofacial findings in a patient with methylmalonic aciduria and homocystinuria: review and a case report.
Topics: Abnormalities, Multiple; Child; Craniofacial Abnormalities; Face; Female; Homocystinuria; Humans; Me | 2010 |
Cobalamin C defect: natural history, pathophysiology, and treatment.
Topics: Age of Onset; Homocysteine; Humans; Methionine; Methylmalonic Acid; Models, Biological; Vitamin B 12 | 2011 |
Biomarkers of cobalamin (vitamin B12) deficiency and its application.
Topics: Aging; Biomarkers; Cognition Disorders; Erythrocyte Indices; Female; Homocysteine; Humans; Male; Met | 2011 |
Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility.
Topics: Biomarkers; Circadian Rhythm; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Transcobalamin | 2011 |
Overview of a roundtable on NHANES monitoring of biomarkers of folate and vitamin B-12 status: measurement procedure issues.
Topics: Biomarkers; Chromatography, Liquid; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Nutrition | 2011 |
Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II.
Topics: Biomarkers; Homocysteine; Humans; Methylmalonic Acid; Public Health; Transcobalamins; Vitamin B 12; | 2011 |
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary.
Topics: Biomarkers; Cognition Disorders; Homocysteine; Humans; Methylmalonic Acid; Nutrition Surveys; Public | 2011 |
The importance of methylmalonic acid dosage on the assessment of patients with neurological manifestations following bariatric surgery.
Topics: Female; Gastric Bypass; Humans; Methylmalonic Acid; Nervous System Diseases; Obesity; Vitamin B 12 D | 2011 |
Combined methylmalonic acidemia and homocystinuria, cblC type. I. Clinical presentations, diagnosis and management.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Carrier Proteins; Child; Child, Preschool; Female; | 2012 |
Vitamin B₁₂ status, cognitive decline and dementia: a systematic review of prospective cohort studies.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition; Cognition Disorders; Cognitive Dysfunction; Dementia | 2012 |
Vitamin B12 in neurology and ageing; clinical and genetic aspects.
Topics: Aging; Humans; Methylmalonic Acid; Neurology; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Systematic review with dose-response meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned's prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elder
Topics: Adult; Aged; Aging; Biomarkers; European Union; Evidence-Based Medicine; Humans; Methylmalonic Acid; | 2013 |
Clinical practice. Vitamin B12 deficiency.
Topics: Administration, Oral; Anemia, Pernicious; Child; Child Nutrition Disorders; Diagnostic Errors; Femal | 2013 |
Modern approaches to the investigation of vitamin B12 deficiency.
Topics: Anemia, Pernicious; Antibodies, Blocking; Gastrins; Humans; Intrinsic Factor; Methylmalonic Acid; Pa | 2002 |
Vegetarian lifestyle and monitoring of vitamin B-12 status.
Topics: Analysis of Variance; Diet, Vegetarian; Hemoglobins; Homocysteine; Humans; Methylmalonic Acid; Trans | 2002 |
Vitamin B12 deficiency.
Topics: Humans; Malabsorption Syndromes; Mental Disorders; Methylmalonic Acid; Nervous System Diseases; Prac | 2003 |
[Diagnosis of vitamin B12 deficiency--time for reflection].
Topics: Biomarkers; Homocysteine; Humans; Methylmalonic Acid; Sensitivity and Specificity; Vitamin B 12; Vit | 2003 |
[Vitamin B12 in the Nordic countries. Deficiency, diagnosis, treatment in Sweden].
Topics: Biomarkers; Homocysteine; Humans; Methylmalonic Acid; Practice Patterns, Physicians'; Scandinavian a | 2003 |
Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence.
Topics: Adolescent; Child; Child, Preschool; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocystein | 2003 |
Vitamin B12 and folate depletion in cognition: a review.
Topics: Cognition; Cognition Disorders; Dementia; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; M | 2004 |
[Cobalamin--a critical nutritive element in old age].
Topics: Aged; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Novel and established markers of cobalamin deficiency: complementary or exclusive diagnostic strategies.
Topics: Biomarkers; Diagnosis, Differential; Homocysteine; Humans; Methylmalonic Acid; Transcobalamins; Vita | 2005 |
[Diagnosis of vitamin B12 deficiency revised].
Topics: Homocysteine; Humans; Methylmalonic Acid; Predictive Value of Tests; Schilling Test; Sensitivity and | 2005 |
Clinical inquiries. How do we evaluate a marginally low B12 level?
Topics: Evaluation Studies as Topic; Evidence-Based Medicine; Family Practice; Female; Homocysteine; Humans; | 2007 |
Neurodegeneration and chronic renal failure in methylmalonic aciduria--a pathophysiological approach.
Topics: Animals; Brain; Dicarboxylic Acids; Energy Metabolism; Humans; Kidney; Kidney Failure, Chronic; Meth | 2008 |
[Measurement of methylmalonic acid, homocysteine and methionine in cobalamin and folate deficiencies and homocysteinuria].
Topics: Amino Acid Metabolism, Inborn Errors; Biomarkers; Diagnosis, Differential; Folic Acid; Folic Acid De | 2008 |
Cobalamin deficiency and related disorders in infancy and childhood.
Topics: Child, Preschool; Diagnosis, Differential; Female; Folic Acid Deficiency; Homocystinuria; Humans; In | 1982 |
How to diagnose cobalamin deficiency.
Topics: Gastrins; History, 19th Century; History, 20th Century; Homocysteine; Humans; Methylmalonic Acid; Pe | 1994 |
[Neonatal hemolytic-uremic syndrome, methylmalonic aciduria and homocystinuria caused by intracellular vitamin B 12 deficiency. Value of etiological diagnosis].
Topics: Female; Hemolytic-Uremic Syndrome; Homocystinuria; Humans; Infant, Newborn; Methylmalonic Acid; Vita | 1993 |
[Low serum vitamin B 12 level and vitamin B 12 deficiency in the elderly. When should supplement be provided?].
Topics: Aged; Anemia, Pernicious; Central Nervous System Diseases; Deoxyuridine; Humans; Methylmalonic Acid; | 1994 |
Vitamin B12.
Topics: Humans; Methylmalonic Acid; Nutritional Status; Vitamin B 12; Vitamin B 12 Deficiency | 1993 |
Metabolite assays in cobalamin and folate deficiency.
Topics: Folic Acid Deficiency; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1995 |
[P-methylmalonate and P-homocysteine: metabolic markers of vitamin deficiencies. Background, validity and applications].
Topics: Amino Acids; Biomarkers; Blood Chemical Analysis; Evaluation Studies as Topic; Folic Acid Deficiency | 1996 |
High prevalence of cobalamin deficiency in the elderly.
Topics: Aged; Hematologic Diseases; Homocysteine; Humans; Mental Disorders; Methylmalonic Acid; Nervous Syst | 1996 |
[Neonatal hemolytic-uremic syndrome associated with methylmalonic aciduria and homocystinuria].
Topics: Fatal Outcome; Female; Hemolytic-Uremic Syndrome; Homocystinuria; Humans; Infant, Newborn; Methylmal | 1996 |
Vitamin B12 replacement. To B12 or not to B12?
Topics: Family Practice; Homocysteine; Humans; Methylmalonic Acid; Prevalence; Research Design; Sensitivity | 1997 |
[Blood and urinary level of methylmalonic acid: an important index in evaluating cobalamin deficiency].
Topics: Biomarkers; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 1997 |
Vitamin B-12 deficiency in the elderly: current dilemmas.
Topics: Acyl Coenzyme A; Aged; Aged, 80 and over; Female; Homocysteine; Humans; Male; Methionine; Methylmalo | 1997 |
Methylmalonic acidemia, cobalamin C type, presenting with cutaneous manifestations.
Topics: Acrodermatitis; Amino Acid Metabolism, Inborn Errors; Biopsy; Cheilitis; Female; Humans; Infant, New | 1997 |
[Inherited disorders of cobalamin metabolism].
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Biomarkers; Child, Preschool; Diagnosis, | 1998 |
Vitamin B12 deficiency in older people: improving diagnosis and preventing disability.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 | 1998 |
Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician.
Topics: Antibodies; Clinical Laboratory Techniques; Clinical Trials as Topic; Decision Trees; Diagnosis, Dif | 1999 |
[Diagnosis of vitamin B12 deficiency: only apparently child's play].
Topics: Aging; Anemia, Pernicious; Blood Cell Count; Diagnosis, Differential; Folic Acid Deficiency; Gastrit | 1999 |
Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate.
Topics: Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B | 2000 |
[Homocysteine and methylmalonic acid as markers of cobalamin/folate status. The association to neuropsychiatric symptoms in the elderly is explored].
Topics: Aged; Biomarkers; Cognition Disorders; Diagnosis, Differential; Folic Acid Deficiency; Geriatric Psy | 2000 |
Methylmalonic acid: a test whose time has come?
Topics: Aged; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2001 |
Elevated serum methylmalonic acid. How much comes from cobalamin deficiency and how much comes from the kidneys?
Topics: Humans; Kidney; Methylmalonic Acid; Vitamin B 12 Deficiency | 2002 |
Effect of vitamin B 12 deprivation on CoA intermediates related to propionate metabolism.
Topics: Animals; Citrates; Cobamides; Coenzyme A; Liver; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Propi | 1975 |
The laboratory diagnosis of megaloblastic anemias.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Clinical Laboratory Techniques; Erythrocytes; | 1978 |
[Determination of vitamin b12 deficiency].
Topics: Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 1992 |
Cobalamin and folate: recent developments.
Topics: Anemia, Megaloblastic; Female; Folic Acid; Humans; Methylation; Methylmalonic Acid; Nervous System D | 1992 |
[Determination of homocysteine and methylmalonic acid in cobalamin deficiency. Diagnostic problem with a solution?].
Topics: Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1991 |
Diagnosis of megaloblastic anemia.
Topics: Anemia, Megaloblastic; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1991 |
41 trials available for methylmalonic acid and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Effect of oral or injectable supplementation with cobalamin in dogs with hypocobalaminemia caused by chronic enteropathy or exocrine pancreatic insufficiency.
Topics: Animals; Dietary Supplements; Dog Diseases; Dogs; Exocrine Pancreatic Insufficiency; Inflammatory Bo | 2022 |
Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Cholesterol; Diet, Vegan; Fatty Acids; Female; Healthy V | 2019 |
Infantile Tremor Syndrome or a Neurocutaneous Infantile B12 Deficiency (NIB) Syndrome?
Topics: Adolescent; Adult; Biomarkers; Child; Child, Preschool; Erythrocyte Indices; Female; Folic Acid; Hom | 2020 |
Cobalamin and folate status in women during early pregnancy in Bhaktapur, Nepal.
Topics: Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Nepal; Pregnancy; Vitamin B 12; Vitami | 2021 |
Cobalamin and Folate Status among Breastfed Infants in Bhaktapur, Nepal.
Topics: Biomarkers; Breast Feeding; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homo | 2018 |
The Effect of Whey and Soy Protein Isolates on Cognitive Function in Older Australians with Low Vitamin B
Topics: Aged; Australia; Cognition; Cross-Over Studies; Female; Folic Acid; Homocysteine; Humans; Male; Memo | 2018 |
Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations.
Topics: Administration, Oral; Animals; Dietary Supplements; Dog Diseases; Dogs; Female; Homocysteine; Infusi | 2019 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study.
Topics: Biomarkers; Child Development; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Follow- | 2013 |
Vitamin B-12 treatment of asymptomatic, deficient, elderly Chileans improves conductivity in myelinated peripheral nerves, but high serum folate impairs vitamin B-12 status response assessed by the combined indicator of vitamin B-12 status.
Topics: Aged; Chile; Dietary Supplements; Female; Folic Acid; Food, Fortified; Homocysteine; Humans; Male; M | 2016 |
Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial.
Topics: Breast Feeding; Child Development; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; In | 2015 |
Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial.
Topics: Breast Feeding; Child Development; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; In | 2015 |
Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial.
Topics: Breast Feeding; Child Development; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; In | 2015 |
Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial.
Topics: Breast Feeding; Child Development; Dietary Supplements; Female; Folic Acid; Homocysteine; Humans; In | 2015 |
Methylmalonic acid and neutrophil morphometric index in laboratory diagnosis of cobalamin deficiency without macrocytosis.
Topics: Aged; Cell Nucleus; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Neutrophils; Vitamin B 12 | 2016 |
Whey protein isolate improves vitamin B
Topics: Aged; Australia; Cross-Over Studies; Diet; Dietary Supplements; DNA Damage; Female; Folic Acid; Homo | 2017 |
Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial.
Topics: Aged; Aging; Bread; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocyst | 2008 |
Vitamin B(12) deficiency is linked with long-term use of proton pump inhibitors in institutionalized older adults: could a cyanocobalamin nasal spray be beneficial?
Topics: Administration, Inhalation; Aged; Aged, 80 and over; Female; Humans; Institutionalization; Long-Term | 2010 |
Oral vitamin B12 for patients suspected of subtle cobalamin deficiency: a multicentre pragmatic randomised controlled trial.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Specimen Collect | 2011 |
The vitamin B12 absorption test, CobaSorb, identifies patients not requiring vitamin B12 injection therapy.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Biomarkers; Blood Chemical Analysis; Female; H | 2011 |
Vitamin B-12 supplementation of rural Mexican women changes biochemical vitamin B-12 status indicators but does not affect hematology or a bone turnover marker.
Topics: Adult; Alkaline Phosphatase; Bone Remodeling; C-Reactive Protein; Dietary Supplements; Female; Ferri | 2012 |
A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status.
Topics: Aged; Aged, 80 and over; Aging; Apoproteins; Biomarkers; Creatinine; Cross-Sectional Studies; Dietar | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults.
Topics: Administration, Oral; Age Factors; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Female | 2002 |
Vitamin B-12 treatment has limited effect on health-related quality of life among individuals with elevated plasma methylmalonic acid: a randomized placebo-controlled study.
Topics: Aged; Double-Blind Method; Female; Humans; Male; Methylmalonic Acid; Quality of Life; Surveys and Qu | 2003 |
Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid, vitamin B12 and vitamin B6: a randomised trial.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocystein | 2003 |
Holotranscobalamin--a first choice assay for diagnosing early vitamin B deficiency?
Topics: Adult; Aged; Aged, 80 and over; Anemia; Biomarkers; Creatinine; Female; Homocysteine; Humans; Male; | 2005 |
Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study.
Topics: Aged; Cognition; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Geriatrics; Homocys | 2005 |
Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Biomarkers; Dietary Supplements; Dose-Response Relati | 2005 |
Effect of supplementation with cobalamin carried either by a milk product or a capsule in mildly cobalamin-deficient elderly Dutch persons.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Animals; Biological Availability; Capsules; Dietary S | 2005 |
The limited value of methylmalonic acid, homocysteine and holotranscobalamin in the diagnosis of early B12 deficiency.
Topics: Diagnosis; Homocysteine; Humans; Methylmalonic Acid; Sensitivity and Specificity; Transcobalamins; V | 2006 |
Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Cognition; Cognition Disorders; Dietary Supplements; | 2006 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Huma | 2007 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Huma | 2007 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Huma | 2007 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Huma | 2007 |
Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Cohort Studies; Creatinine; Dietary Supplements; Dose-R | 2006 |
Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations.
Topics: Aged; Aged, 80 and over; Avitaminosis; Citrates; Cystathionine; Double-Blind Method; Female; Folic A | 1995 |
Methylmalonic acid and homocysteine in plasma as indicators of functional cobalamin deficiency in infants on macrobiotic diets.
Topics: Diet, Macrobiotic; Female; Homocysteine; Humans; Infant; Male; Methylmalonic Acid; Reference Values; | 1994 |
Performance of the serum cobalamin assay for diagnosis of cobalamin deficiency.
Topics: Blood Proteins; False Positive Reactions; Female; Folic Acid; Follow-Up Studies; Hemoglobins; Hospit | 1994 |
Comparison of the deoxyuridine suppression test with serum levels of methylmalonic acid and homocysteine in mild cobalamin deficiency.
Topics: Bone Marrow; Deoxyuridine; Female; Homocystine; Humans; Male; Methylmalonic Acid; Tetrahydrofolates; | 1996 |
Reversible dysregulation of the mitochondrial ATP synthase in skin fibroblasts from children with vitamin B12-dependent methylmalonic acidaemia.
Topics: ATP Synthetase Complexes; Calcium; Cells, Cultured; Child; Electron Transport Complex IV; Fibroblast | 1997 |
Effective treatment of cobalamin deficiency with oral cobalamin.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Folic Acid; Hematocrit; Homocysteine; | 1998 |
Pathological changes in cobalt-supplemented and non-supplemented twin lambs in relation to blood concentrations of methylmalonic acid and homocysteine.
Topics: Animals; Brain; Brain Diseases; Cobalt; Copper; Diet; Female; Hepatitis, Chronic; Homocysteine; Litt | 1999 |
The plasma homocysteine concentration is better than that of serum methylmalonic acid as a marker for sociopsychological performance in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Dementia; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; | 2000 |
Increased plasma methylmalonic acid level does not predict clinical manifestations of vitamin B12 deficiency.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Denmark; Female; Follow-Up Studies; Humans; | 2001 |
Vitamin B12 treatment normalizes metabolic markers but has limited clinical effect: a randomized placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; N | 2001 |
Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons.
Topics: Aged; Aged, 80 and over; Aging; Brain; Cognition; Electroencephalography; Female; Humans; Hydroxocob | 2001 |
428 other studies available for methylmalonic acid and Deficiency, Vitamin B 12
| Article | Year |
|---|---|
Clinical relevance of testing for metabolic vitamin B12 deficiency in patients with polyneuropathy.
Topics: Homocysteine; Humans; Methylmalonic Acid; Polyneuropathies; Retrospective Studies; Vitamin B 12; Vit | 2022 |
The roles of homocysteinemia and methylmalonic acidemia in kidney injury in atypical hemolytic uremic syndrome caused by cobalamin C deficiency.
Topics: Acute Kidney Injury; Amino Acid Metabolism, Inborn Errors; Atypical Hemolytic Uremic Syndrome; Femal | 2022 |
Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES.
Topics: Adult; Biomarkers; Diabetes Mellitus, Type 2; Humans; Methylmalonic Acid; Nutrition Surveys; Vitamin | 2022 |
Vitamin B
Topics: Creatinine; Homocysteine; Humans; Methylmalonic Acid; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Defi | 2022 |
Reference intervals for plasma vitamin B12 and plasma/serum methylmalonic acid in Danish children, adults and elderly.
Topics: Adult; Aged; Child; Denmark; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Reference Values; | 2022 |
[Methylmalonic acid: Specific marker of chronic nitrous oxide abuse?]
Topics: Humans; Methylmalonic Acid; Nitrous Oxide; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Does Metformin Treatment in Pediatric Population Cause Vitamin B12 Deficiency?
Topics: Adolescent; Child; Diabetes Mellitus, Type 2; Female; Homocysteine; Humans; Male; Metabolic Syndrome | 2022 |
Clinical and biochemical outcomes in cobalamin C deficiency with use of high-dose hydroxocobalamin in the early neonatal period.
Topics: Amino Acid Metabolism, Inborn Errors; Female; Humans; Hydroxocobalamin; Infant, Newborn; Methylmalon | 2022 |
A case of vitamin B12 deficiency neurological syndrome in a young adult due to late-onset cobalamin C (CblC) deficiency: a diagnostic challenge.
Topics: Adult; Female; Folic Acid; Humans; Methylmalonic Acid; Nervous System Diseases; Vitamin B 12; Vitami | 2022 |
Vitamin B-12 malabsorption and renal function are critical considerations in studies of folate and vitamin B-12 interactions in cognitive performance: NHANES 2011-2014.
Topics: Aged; Cognition; Dietary Supplements; Folic Acid; Homocysteine; Humans; Kidney; Methylmalonic Acid; | 2022 |
Very long-term outcomes in 23 patients with cblA type methylmalonic acidemia.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Child; Humans; Intellectual Disability; Kidney Failure, | 2022 |
Validation of an automated UPLC-MS/MS method for methylmalonic acid in serum/plasma and its application on clinical samples.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Methylmalonic Acid; Middle Age | 2022 |
Pregnancy homocysteine and cobalamin status predict childhood metabolic health in the offspring.
Topics: Birth Weight; Child; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Pregnancy; | 2023 |
Nitrous oxide in labour predicted newborn screening total homocysteine and is a potential risk factor for infant vitamin B12 deficiency.
Topics: Case-Control Studies; Homocysteine; Humans; Infant; Infant, Newborn; Methylmalonic Acid; Neonatal Sc | 2022 |
Topics: Dietary Supplements; Folic Acid; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2022 |
Acquired Vitamin B12 Deficiency in Newborns: Positive Impact on Newborn Health through Early Detection.
Topics: Biomarkers; Early Diagnosis; Female; Homocysteine; Humans; Hydroxocobalamin; Infant; Infant Health; | 2022 |
Pearls & Oy-sters: Late-Onset Cobalamin C Deficiency Presenting With Subacute Combined Degeneration.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Child; Female; Humans; Methylmalonic Acid; Spinal Cord | 2023 |
[A Method for Quantitative Determination of Amino Acids and Organic Acids in Trace Random Urine and Preliminary Application in Research on Vitamin B12 Nutritional Status and Related Metabolism].
Topics: Amino Acids; Child; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Methylmalonic | 2022 |
Comparison of biomarker for diagnosis of nitrous oxide abuse: challenge of cobalamin metabolic parameters, a retrospective study.
Topics: Biomarkers; Humans; Methylmalonic Acid; Nitrous Oxide; Retrospective Studies; Substance-Related Diso | 2023 |
Functional vitamin B12 deficiency: Improving methylmalonic acid reference intervals in urine.
Topics: Biomarkers; Female; Humans; Methylmalonic Acid; Pregnancy; Prospective Studies; Vitamin B 12; Vitami | 2023 |
Feline hyperammonemia associated with functional cobalamin deficiency: A case report.
Topics: Amino Acids; Ammonia; Animals; Cat Diseases; Cats; Female; Hyperammonemia; Methylmalonic Acid; Urea; | 2023 |
Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition; Cognitive Dysfunction; Humans; Meth | 2023 |
The association between methylmalonic acid, a biomarker of mitochondria dysfunction, and phenotypic age acceleration: A population-based study.
Topics: Aged; Biomarkers; Cross-Sectional Studies; Female; Homocysteine; Humans; Male; Methylmalonic Acid; N | 2024 |
Methylmalonic acid, vitamin B12, and mortality risk in patients with preexisting coronary heart disease: a prospective cohort study.
Topics: Adult; Aged; Cardiovascular Diseases; Humans; Male; Methylmalonic Acid; Nutrition Surveys; Prospecti | 2023 |
Isolated subacute combined degeneration in late-onset cobalamin C deficiency in children: Two case reports and literature review.
Topics: Adolescent; Ataxia; Brain; Carrier Proteins; Child; Female; Homocysteine; Homocystinuria; Humans; In | 2019 |
Paradoxical Elevation of Both Serum B12 and Methylmalonic Acid Levels in Assessing B12 Status in Children With Short-Bowel Syndrome.
Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Methylmalonic Acid; Retrospective Studies; Shor | 2020 |
Association of vitamin B12, methylmalonic acid, and functional parameters.
Topics: Adult; Aged; Cognition; Cognitive Dysfunction; Female; Hand Strength; Humans; Male; Methylmalonic Ac | 2020 |
Vitamin B12.
Topics: Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Diagnostic Accuracy of Holotranscobalamin, Vitamin B12, Methylmalonic Acid, and Homocysteine in Detecting B12 Deficiency in a Large, Mixed Patient Population.
Topics: Adult; Aged; Biomarkers; Cohort Studies; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Mid | 2020 |
A False-Positive Case of Methylmalonic Aciduria by Tandem Mass Spectrometry Newborn Screening Dependent on Maternal Malnutrition in Pregnancy.
Topics: Amino Acid Metabolism, Inborn Errors; Chromatography, Liquid; Female; Humans; Infant, Newborn; Malnu | 2020 |
Pulmonary hypertension in late-onset Methylmalonic Aciduria and Homocystinemia: a case report.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Female; Homocystinuria; Humans; Hypertension, Pulmonary | 2020 |
Functional vitamin B12 deficiency in phenylketonuria patients and healthy controls: An evaluation with combined indicator of vitamin B12 status as a biochemical index.
Topics: Adolescent; Biomarkers; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Homocyste | 2020 |
Electrochemical sensing of vitamin B
Topics: Biomarkers; Biosensing Techniques; Carbon Fiber; Electrochemical Techniques; Electrodes; Gold; Human | 2020 |
Diagnostic Challenges Using a 2-Tier Strategy for Methylmalonic Acidurias: Data from 1.2 Million Dried Blood Spots.
Topics: Amino Acid Metabolism, Inborn Errors; Carnitine; Diagnosis, Differential; Dried Blood Spot Testing; | 2020 |
Efficacy of intramuscular hydroxocobalamin supplementation in cats with cobalamin deficiency and gastrointestinal disease.
Topics: Animals; Cat Diseases; Cats; Dietary Supplements; Gastrointestinal Diseases; Hydroxocobalamin; Methy | 2020 |
Diagnostic Characteristics of 3-Parameter and 2-Parameter Equations for the Calculation of a Combined Indicator of Vitamin B12 Status to Predict Cobalamin Deficiency in a Large Mixed Patient Population.
Topics: Biomarkers; Homocysteine; Humans; Methylmalonic Acid; ROC Curve; Transcobalamins; Vitamin B 12; Vita | 2020 |
Test utilization for the diagnosis of vitamin B12 and folate deficiency in local clinics in Korea.
Topics: Adult; Anemia, Macrocytic; Blood Chemical Analysis; Erythrocyte Indices; Folic Acid; Folic Acid Defi | 2020 |
Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study.
Topics: Aged; Female; Humans; Kidney; Kidney Function Tests; Male; Methylmalonic Acid; Middle Aged; Mortalit | 2020 |
A high frequency and geographical distribution of MMACHC R132* mutation in children with cobalamin C defect.
Topics: Adolescent; Child; Child, Preschool; Exons; Female; Homocysteine; Humans; India; Infant; Infant, New | 2021 |
Cross-sectional association between vitamin B12 status and probable postpartum depression in Indian women.
Topics: Adolescent; Adult; Cesarean Section; Cross-Sectional Studies; Depression, Postpartum; Diet; Female; | 2021 |
Cobalamin J disease detected on newborn screening: Novel variant and normal neurodevelopmental course.
Topics: Amino Acid Metabolism, Inborn Errors; ATP-Binding Cassette Transporters; Female; Genetic Predisposit | 2021 |
Maternal vitamin B12 deficiency and perinatal outcomes in southern India.
Topics: Adult; Biomarkers; Cohort Studies; Female; Folic Acid; Humans; India; Infant, Newborn; Maternal Nutr | 2021 |
[Cobalamin in the complex treatment and prevention of cognitive impairment].
Topics: Aged; Biomarkers; Cognitive Dysfunction; Female; Folic Acid; Humans; Methylmalonic Acid; Vitamin B 1 | 2021 |
Implementation of second-tier tests in newborn screening for the detection of vitamin B
Topics: Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Neonatal Screening; Propionic Acidemia; V | 2021 |
Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children.
Topics: Adult; Asia; Child Development; Cognition; Cognitive Dysfunction; Female; Homocysteine; Humans; Infa | 2017 |
South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women.
Topics: Adolescent; Adult; Asia; Biomarkers; Canada; Ethnicity; Female; Gestational Age; Humans; India; Meth | 2017 |
X-Linked Cobalamin Disorder (HCFC1) Mimicking Nonketotic Hyperglycinemia With Increased Both Cerebrospinal Fluid Glycine and Methylmalonic Acid.
Topics: Biomarkers; Brain; Diagnosis, Differential; Genetic Diseases, X-Linked; Glycine; Humans; Hyperglycin | 2017 |
A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice.
Topics: Anemia, Megaloblastic; Animals; Body Weight; Cimicifuga; Female; Folic Acid; Homocysteine; Kidney; L | 2017 |
Neuropsychiatric and neurological problems among Vitamin B12 deficient young vegetarians.
Topics: Adult; Case-Control Studies; Comorbidity; Cross-Sectional Studies; Depression; Female; Folic Acid; H | 2017 |
Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity.
Topics: Adult; Body Mass Index; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Insulin Resistance; | 2018 |
Thrombotic microangiopathy and breastfeeding: where is the link? Answers.
Topics: Breast Feeding; Humans; Infant; Male; Methylmalonic Acid; Thrombotic Microangiopathies; Vitamin B 12 | 2018 |
Vitamin B12 Deficiency: Recognition and Management.
Topics: Humans; Hyperhomocysteinemia; Methylmalonic Acid; Risk Factors; Vitamin B 12; Vitamin B 12 Deficienc | 2017 |
Vitamin B12 deficiency in inflammatory bowel disease: a prospective observational pilot study.
Topics: Codon, Nonsense; Colitis, Ulcerative; Crohn Disease; Female; Fucosyltransferases; Galactoside 2-alph | 2017 |
Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series.
Topics: Biomarkers; Blind Loop Syndrome; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; M | 2018 |
Vitamin B12 deficiency and impaired expression of amnionless during aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Biomarkers; Female; Humans; Longitudinal Studies; Ma | 2018 |
Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Male; Metform | 2018 |
Late-onset cobalamin C deficiency Chinese sibling patients with neuropsychiatric presentations.
Topics: Adolescent; Adult; Asian People; Atrophy; Brain; Brain Diseases; Carrier Proteins; Child; Child, Pre | 2018 |
Prospective long-term evaluation of parenteral hydroxocobalamin supplementation in juvenile beagles with selective intestinal cobalamin malabsorption (Imerslund-Gräsbeck syndrome).
Topics: Anemia, Megaloblastic; Animals; Creatinine; Dog Diseases; Dogs; Drug Administration Schedule; Female | 2018 |
Vitamin B12 deficiency after esophagectomy with gastric tube reconstruction for esophageal cancer.
Topics: Adult; Aged; Cross-Sectional Studies; Esophageal Neoplasms; Esophagectomy; Female; Gastroplasty; Hum | 2017 |
Methylmalonic Acid Levels and their Relation with Cobalamin Supplementation in Spanish Vegetarians.
Topics: Adult; Biomarkers; Chromatography, Liquid; Cross-Sectional Studies; Diet, Vegan; Diet, Vegetarian; D | 2018 |
Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund-Gräsbeck syndrome) maintains normal clinical and cellular cobalamin status.
Topics: Administration, Oral; Anemia, Megaloblastic; Animals; Dog Diseases; Dogs; Female; Malabsorption Synd | 2019 |
Methylmalonic Acid and Homocysteine as Indicators of Vitamin B12 Deficiency in Patients with Gastric Cancer after Gastrectomy.
Topics: Adult; Aged; Biomarkers; Female; Gastrectomy; Homocysteine; Humans; Male; Methylmalonic Acid; Middle | 2019 |
Patterns and utility of vitamin B12 and folate testing in patients with isolated thrombocytopenia.
Topics: Adult; Aged; Aged, 80 and over; Diagnostic Tests, Routine; Female; Folic Acid; Folic Acid Deficiency | 2019 |
Investigating vitamin B12 deficiency.
Topics: Adult; Aged; Biomarkers; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Infant; Malabsorp | 2019 |
Age-specific reference ranges are needed to interpret serum methylmalonic acid concentrations in the US population.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Biomarkers; Ethnicity; Female; Humans; Kidn | 2019 |
Supraphysiological vitamin B12 serum concentrations without supplementation: the pitfalls of interpretation.
Topics: Dietary Supplements; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2020 |
Serum homocysteine and methylmalonic acid concentrations in Chinese Shar-Pei dogs with cobalamin deficiency.
Topics: Animals; Dog Diseases; Dogs; Genetic Predisposition to Disease; Homocysteine; Methylmalonic Acid; Re | 2013 |
Advanced age as a risk factor for folate-associated functional cobalamin deficiency.
Topics: Aged; Aged, 80 and over; Causality; Cognition Disorders; Comorbidity; Female; Folic Acid; Geriatric | 2013 |
[Outcomes of patients with combined methylmalonic acidemia and homocystinuria after treatment].
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Betaine; Carnitine; Child; Child, Preschool | 2013 |
Cost-minimisation in vitamin B12 deficiencies: expensive diagnostics can reduce spending.
Topics: Chemistry, Pharmaceutical; Cost-Benefit Analysis; Humans; Injections, Intramuscular; Methylmalonic A | 2013 |
Modeling a methylmalonic acid-derived change point for serum vitamin B-12 for adults in NHANES.
Topics: Adult; Aged; Cross-Sectional Studies; Female; Humans; Linear Models; Male; Methylmalonic Acid; Middl | 2013 |
Problems related to the diagnosis of vitamin B12 deficiency optic neuropathy.
Topics: False Positive Reactions; Homocysteine; Humans; Methylmalonic Acid; Optic Nerve Diseases; Predictive | 2014 |
Early biochemical and hematological response to intramuscular cyanocobalamin therapy in vitamin B(12)-deficient patients.
Topics: Aged; Chromatography, High Pressure Liquid; Cysteine; Erythrocyte Indices; Female; Folic Acid; Homoc | 2013 |
A relationship between tube length and intraocular pressure after glaucoma drainage implant surgery cannot be explained by Poiseuille's law.
Topics: Female; Homocysteine; Humans; Male; Methylmalonic Acid; Vitamin B 12 Deficiency | 2014 |
Serum methylmalonic acid and holotranscobalamin-II as markers for vitamin B12 deficiency in end-stage renal disease patients.
Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Female; Humans; Kidney Failure, Chronic; | 2013 |
Methylmalonic acid and homocysteine assessment in the detection of vitamin B12 deficiency in patients with bilateral visual loss - authors' reply.
Topics: Female; Homocysteine; Humans; Male; Methylmalonic Acid; Vitamin B 12 Deficiency | 2014 |
Role of serum holotranscobalamin (holoTC) in the diagnosis of patients with low serum cobalamin. Comparison with methylmalonic acid and homocysteine.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Female; Homocysteine; Humans; Male; Methylmalonic Acid; | 2014 |
4-ethylphenyl-cobalamin impairs tissue uptake of vitamin B12 and causes vitamin B12 deficiency in mice.
Topics: Animals; Biomarkers; Female; Methylmalonic Acid; Mice; Molecular Structure; Tissue Distribution; Tra | 2013 |
A relationship between tube length and intra-ocular pressure after glaucoma drainage implant surgery cannot be explained by Poiseuille's law - author's reply.
Topics: Female; Homocysteine; Humans; Male; Methylmalonic Acid; Vitamin B 12 Deficiency | 2014 |
Adult-onset eculizumab-resistant hemolytic uremic syndrome associated with cobalamin C deficiency.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Antibodies, Monoclonal, Humanized; Betaine; Biopsy; Car | 2014 |
Vitamin B12 deficiency in relation to functional disabilities.
Topics: Activities of Daily Living; Aged; Biomarkers; Cognition; Disability Evaluation; Disabled Persons; Fe | 2013 |
Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study.
Topics: Aged; Biomarkers; Cognition Disorders; Cross-Sectional Studies; Diet; Female; Folic Acid; Food, Fort | 2014 |
Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes.
Topics: Adult; Aged; Asian People; Biomarkers; China; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Fema | 2014 |
Don't forget methylmalonic acid quantification in symptomatic exclusively breast-fed infants.
Topics: Biomarkers; Breast Feeding; Humans; Infant; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficienc | 2014 |
Plasma vitamin B12, methylmalonic acid and heart rate variability in healthy young Indian adults.
Topics: Adult; Heart Rate; Homocysteine; Humans; India; Male; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 | 2013 |
Methylmalonic acid quantified in dried blood spots provides a precise, valid, and stable measure of functional vitamin B-12 status in healthy women.
Topics: Adult; Chromatography, Liquid; Cross-Sectional Studies; Dried Blood Spot Testing; Fasting; Female; H | 2014 |
Maternal vitamin B12 deficiency detected in expanded newborn screening.
Topics: Carnitine; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid; Neonatal S | 2014 |
Relationship between cobalamin-dependent metabolites and both serum albumin and alpha1 -proteinase inhibitor concentrations in hypocobalaminemic dogs of 7 different breeds.
Topics: alpha-Macroglobulins; Animals; Biomarkers; Breeding; Dog Diseases; Dogs; Female; Homocysteine; Male; | 2014 |
Reliable and powerful laboratory markers of cobalamin deficiency in the newborn: plasma and urinary methylmalonic acid.
Topics: Adult; Biomarkers; Cohort Studies; Female; Homocysteine; Humans; Infant, Newborn; Methylmalonic Acid | 2016 |
Micronutrient status in female university students: iron, zinc, copper, selenium, vitamin B12 and folate.
Topics: Adolescent; Adult; Anemia, Iron-Deficiency; Australia; Biomarkers; Body Mass Index; Copper; Cross-Se | 2014 |
Functional cobalamin (vitamin B12) deficiency: role of advanced age and disorders associated with increased oxidative stress.
Topics: Aged; Aged, 80 and over; Aging; Alcohol Drinking; Connecticut; Diabetes Mellitus; Dietary Supplement | 2015 |
Vitamin B12-responsive neuropathies: A case series.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antioxidants; Biotransformation; Female; Homoc | 2016 |
Diagnosis of vitamin B12 deficiency in patients with myeloproliferative disorders.
Topics: Aged; Female; Follow-Up Studies; Humans; Male; Methylmalonic Acid; Middle Aged; Myeloproliferative D | 2015 |
Pitfalls in the diagnostic evaluation of subacute combined degeneration.
Topics: Adult; Dietary Supplements; Homocysteine; Humans; Male; Methylmalonic Acid; Subacute Combined Degene | 2015 |
Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Biomarkers; Erythrocyte Count; Female; Folic Acid; Homo | 2015 |
[CME - laboratory 41. Evaluating vitamin B12 status].
Topics: Clinical Laboratory Techniques; Homocysteine; Humans; Methylmalonic Acid; Reference Values; Transcob | 2015 |
Low Cobalamin Levels as Predictors of Cobalamin Deficiency: Importance of Comorbidities Associated with Increased Oxidative Stress.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Comorbidity; Female; Homocysteine; Humans; Male; Methylm | 2016 |
Elevation of urinary methylmolonic acid induces the suppression of megalin-mediated endocytotic cycles during vitamin B12 deficiency.
Topics: Animals; Animals, Suckling; Cell Line; Endocytosis; Gene Expression Regulation; HEK293 Cells; Humans | 2015 |
Prevalence and Risk Factors for Functional Vitamin B12 Deficiency in Patients with Crohn's Disease.
Topics: Adult; Biomarkers; Colitis, Ulcerative; Crohn Disease; Female; Humans; Ileum; Male; Methylmalonic Ac | 2015 |
Biochemical Identification of Vitamin B12 Deficiency in a Medical Office.
Topics: Ambulatory Care; Area Under Curve; Biomarkers; Cross-Sectional Studies; Early Diagnosis; Homocystein | 2015 |
Nutritional Supplementation with Chlorella pyrenoidosa Lowers Serum Methylmalonic Acid in Vegans and Vegetarians with a Suspected Vitamin B₁₂ Deficiency.
Topics: Adult; Biological Availability; Chlorella; Diet, Vegan; Diet, Vegetarian; Dietary Supplements; Hemat | 2015 |
Nitrous Oxide Abuse and Vitamin B12 Action in a 20-Year-Old Woman: A Case Report.
Topics: Adult; Demyelinating Diseases; Female; Humans; Methylmalonic Acid; Nitrous Oxide; Paresthesia; Spina | 2015 |
Improving Bariatric Patient Aftercare Outcome by Improved Detection of a Functional Vitamin B12 Deficiency.
Topics: Adult; Aftercare; Bariatric Surgery; Dietary Supplements; Female; Humans; Male; Methylmalonic Acid; | 2016 |
Clinical presentation, gene analysis and outcomes in young patients with early-treated combined methylmalonic acidemia and homocysteinemia (cblC type) in Shandong province, China.
Topics: Amino Acid Metabolism, Inborn Errors; Carrier Proteins; China; DNA Mutational Analysis; Female; Gene | 2016 |
Laughing Gas in a Pediatric Emergency Department-Fun for All Participants: Vitamin B12 Status Among Medical Staff Working With Nitrous Oxide.
Topics: Adult; Anesthetics, Inhalation; Case-Control Studies; Cross-Sectional Studies; Emergency Service, Ho | 2016 |
Evaluation of oxidant and antioxidant status in patients with vitamin B12 deficiency.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Case-Control Studies; Female; Homocysteine; Humans; Ma | 2015 |
Methylmalonic Acid and Homocysteine as Indicators of Vitamin B-12 Deficiency in Cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Cross-Sectional Studies; Female; Homocysteine; Humans; M | 2016 |
Added value of next generation gene panel analysis for patients with elevated methylmalonic acid and no clinical diagnosis following functional studies of vitamin B12 metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Coenzyme A Ligases; Female; Genetic Testing; | 2016 |
Functional vitamin B12 deficiency in advanced malignancy: implications for the management of neuropathy and neuropathic pain.
Topics: Aged; Female; Humans; Male; Methylmalonic Acid; Middle Aged; Neoplasms; Neuralgia; Peripheral Nervou | 2016 |
Reference interval of methylmalonic acid concentrations in dried blood spots of healthy, term newborns to facilitate neonatal screening of vitamin B12 deficiency.
Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Methylmalonic Acid; Neonatal Screening; Referenc | 2016 |
Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women.
Topics: Adult; Canada; Diet; Dietary Supplements; DNA Methylation; Female; Fetal Blood; Fetus; Folic Acid; H | 2016 |
Comparison Between Different Intramuscular Vitamin B
Topics: Adult; Aged; Bariatric Surgery; Case-Control Studies; Dietary Supplements; Female; Humans; Injection | 2016 |
Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Cross-Sectional Studies; Energy Intake; Female; Fol | 2016 |
Rapid healing of a patient with dramatic subacute combined degeneration of spinal cord: a case report.
Topics: Antibodies; Gastrins; Gastroscopy; Homocysteine; Humans; Inflammation; Male; Methylmalonic Acid; Mid | 2017 |
Frequent Infections, Hypotonia, and Anemia in a Breastfed Infant.
Topics: Adult; Agammaglobulinemia; Anemia, Megaloblastic; Anemia, Pernicious; Asymptomatic Diseases; Breast | 2017 |
Efficacy of early treatment in patients with cobalamin C disease identified by newborn screening: a 16-year experience.
Topics: Cohort Studies; Dietary Proteins; Female; Homocysteine; Humans; Infant; Infant, Newborn; Longitudina | 2017 |
[Thromboembolic events, abortions and a sick infant--unusual presentation of a vitamin deficiency].
Topics: Abortion, Habitual; Adult; Anemia, Pernicious; Autoimmune Diseases; Breast Feeding; Diagnosis, Diffe | 2008 |
Quantification of methylmalonic acid in human plasma with hydrophilic interaction liquid chromatography separation and mass spectrometric detection.
Topics: Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Multivaria | 2008 |
Clinical and molecular heterogeneity in patients with the cblD inborn error of cobalamin metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Cells, Cultured; Cobamides; Family Health; Female; Fibroblasts | 2009 |
Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism.
Topics: Child; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 6; Female; HeLa Cells; Huma | 2009 |
Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aging; Anemia, Pernicious; Cognition Diso | 2009 |
Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition Disorders; Cohort Studies; Female; Folic Acid; Folic | 2009 |
Vitamin B12 absorption and metabolism in milk-fed lambs.
Topics: Animals; Animals, Newborn; Area Under Curve; Dose-Response Relationship, Drug; Injections, Intramusc | 2009 |
Vitamin B12 status, methylmalonic acidemia, and bacterial overgrowth in short bowel syndrome.
Topics: Acidosis; Adolescent; Humans; Intestines; Male; Methylmalonic Acid; Short Bowel Syndrome; Vitamin B | 2009 |
Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid.
Topics: Animals; Bone and Bones; Bone Density; Bone Remodeling; Cell Differentiation; Cell Line; Cell Prolif | 2009 |
Transcobalamin II deficiency at birth.
Topics: Child, Preschool; Disease Progression; Female; Humans; Infant; Methylmalonic Acid; Pancytopenia; Tra | 2009 |
Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Folic Acid; Homocysteine; Humans; Male; Me | 2009 |
Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria.
Topics: Adult; Ambulatory Care Facilities; Female; Folic Acid; Hemoglobins; Homocysteine; Humans; Methylmalo | 2009 |
N-carbamylglutamate in emergency management of hyperammonemia in neonatal acute onset propionic and methylmalonic aciduria.
Topics: Acute Disease; Amino Acid Metabolism, Inborn Errors; Ammonia; Emergency Medical Services; Female; Gl | 2010 |
Does high folic acid intake affect unrecognized cobalamin deficiency, and how will we know it if we see it?
Topics: Cognition; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 2009 |
Metabolic signs of vitamin B(12) deficiency in humans: computational model and its implications for diagnostics.
Topics: Computer Simulation; Homocysteine; Humans; Methylmalonic Acid; Probability; ROC Curve; Transcobalami | 2010 |
High frequency of vitamin B12 deficiency in a Brazilian population.
Topics: Adult; Age Factors; Aged; Brazil; Humans; Immunoassay; Methylmalonic Acid; Middle Aged; Prevalence; | 2010 |
Quantitation of methylmalonic acid in serum or plasma using isotope dilution-selected ion gas chromatography-mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Reference Standards; Reproducibili | 2010 |
Low cobalamin levels associated with sickle cell disease: Contrasting origins and clinical meanings in two instructive patients.
Topics: Adult; Anemia, Pernicious; Anemia, Sickle Cell; Autoantibodies; Depression; Female; Folic Acid; Gast | 2010 |
Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors.
Topics: Aged; Aging; Anemia; Anemia, Macrocytic; Blood Cell Count; Cognition; Cognition Disorders; Cystatin | 2010 |
Serum vitamin B(12) concentrations among mothers and newborns and follow-up study to assess implication on the growth velocity and the urinary methylmalonic acid excretion.
Topics: Adolescent; Adult; Birth Weight; Body Weight; Child Development; Female; Humans; Infant, Newborn; Li | 2009 |
Vitamin B12-responsive severe leukoencephalopathy and autonomic dysfunction in a patient with "normal" serum B12 levels.
Topics: Autoantibodies; Autonomic Nervous System Diseases; Brain; Cognition Disorders; Depressive Disorder; | 2010 |
Clinical, biochemical, and molecular analysis of combined methylmalonic acidemia and hyperhomocysteinemia (cblC type) in China.
Topics: Amino Acid Metabolism, Inborn Errors; Biomarkers; Carnitine; Carrier Proteins; Child, Preschool; Chi | 2010 |
Serum vitamin B12 concentrations within reference values do not exclude functional vitamin B12 deficiency in PKU patients of various ages.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Female; Homocysteine; Humans; Infant; Male; | 2011 |
44-year-old man with shortness of breath, fatigue, and paresthesia.
Topics: Adult; Anemia, Pernicious; Blood Cell Count; Diagnosis, Differential; Dyspnea; Fatigue; Humans; Male | 2010 |
Hyperpigmentation and hypotonia in a 3-month-old infant.
Topics: Breast Feeding; Female; Humans; Hyperpigmentation; Infant; Maternal Nutritional Physiological Phenom | 2011 |
Inborn errors of cobalamin absorption and metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Anemia, Megaloblastic; Cobamides; Homocysteine; Humans; Hyperh | 2011 |
Intact recovery from early 'acquired methylmalonic aciduria' secondary to maternal atrophic gastritis.
Topics: Amino Acid Metabolism, Inborn Errors; Dietary Supplements; Female; Gastritis, Atrophic; Humans; Infa | 2011 |
Parenteral vitamin B12 in macrocytic hemodialysis patients reduced MMA levels but did not change mean red cell volume or hemoglobin.
Topics: Aged; Aged, 80 and over; Anemia, Macrocytic; Biomarkers; Chi-Square Distribution; Erythrocyte Indice | 2011 |
Vitamin B12 deficiency, hyperhomocysteinemia and thrombosis: a case and control study.
Topics: Adult; Aged; Case-Control Studies; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; M | 2011 |
Association between serum cobalamin and methylmalonic acid concentrations in dogs.
Topics: Animals; Biomarkers; Dog Diseases; Dogs; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2012 |
Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B₁₂ status in the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Discriminant Analysis; Erythrocytes; Female; Folic Acid; | 2011 |
The MMACHC proteome: hallmarks of functional cobalamin deficiency in humans.
Topics: Amino Acid Metabolism, Inborn Errors; Carrier Proteins; Cell Line; Cells, Cultured; Fibroblasts; Fol | 2011 |
Methylmalonic acid quantification in low serum volumes by UPLC-MS/MS.
Topics: Biomarkers; Chromatography, High Pressure Liquid; Cyclohexanes; Drug Stability; Female; Humans; Laur | 2011 |
B-vitamin deficiency is protective against DSS-induced colitis in mice.
Topics: Analysis of Variance; Animals; Body Weight; Colitis; Dextran Sulfate; Gene Expression; Glutathione; | 2011 |
Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?
Topics: Adult; Cross-Sectional Studies; Female; Ferritins; Folic Acid; Food, Fortified; Homocysteine; Humans | 2011 |
Association of cognitive impairment with combinations of vitamin B₁₂-related parameters.
Topics: Aged; Biomarkers; Case-Control Studies; Cognition Disorders; Cross-Sectional Studies; Homocysteine; | 2011 |
Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration.
Topics: Animals; Biomarkers; Brain; Folic Acid Deficiency; Formates; Homocysteine; Hyperhomocysteinemia; Liv | 2012 |
[Treatment response in vitamin B12 deficiency depends on the chosen vitamin B12 preparation].
Topics: Adult; Delayed-Action Preparations; Humans; Injections, Intramuscular; Male; Methylmalonic Acid; Tre | 2011 |
Vitamin B₁₂ deficiency & cognitive impairment in elderly population.
Topics: Diet, Vegetarian; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 | 2011 |
Vitamin B₁₂ deficiency & levels of metabolites in an apparently normal urban south Indian elderly population.
Topics: Aged; Diet, Vegetarian; Erythrocytes; Female; Folic Acid; Helicobacter Infections; Helicobacter pylo | 2011 |
Do we need to reconsider the desirable blood level of vitamin B12?
Topics: Age Factors; Homocysteine; Humans; Methylmalonic Acid; Prognosis; Vitamin B 12; Vitamin B 12 Deficie | 2012 |
Holotranscobalamin: not ready for prime time.
Topics: Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Transcobalamins; Vitamin B 12; V | 2012 |
[Approaches to vitamin B12 deficiency].
Topics: Adult; Aged; Anemia, Iron-Deficiency; Diagnostic Services; Diet, Vegetarian; Female; Homocysteine; H | 2012 |
Methylmalonic acid and homocysteine assessment in the detection of vitamin B12 deficiency in patients with bilateral visual loss.
Topics: Adult; Aged, 80 and over; Blindness; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Middle | 2012 |
Determinants of urinary methylmalonic acid concentration in an elderly population in the United Kingdom.
Topics: Aged; Aged, 80 and over; Biomarkers; Cross-Sectional Studies; Female; Humans; Life Style; Male; Meth | 2012 |
Does an elevated serum vitamin B(12) level mask actual vitamin B(12) deficiency in myeloproliferative disorders?
Topics: Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Humans; Methylmalonic Acid; Middle Aged; My | 2012 |
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Cognitive Dysfunction; Cohort Studies | 2013 |
Bilateral central retinal artery occlusions in an infant with hyperhomocysteinemia.
Topics: Humans; Hydroxocobalamin; Hyperhomocysteinemia; Infant; Injections, Intramuscular; Male; Methylmalon | 2012 |
Cobalamin status in sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Black or African American; Cross-Sectional Studies; District of Columbia | 2013 |
Serum cobalamin, urine methylmalonic acid, and plasma total homocysteine concentrations in Border Collies and dogs of other breeds.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Biomarkers; Chromatography, Gas; Chromatography, High | 2012 |
Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome.
Topics: Adolescent; Adult; Brazil; Child; Child, Preschool; Chromosomes, Human, Pair 21; Down Syndrome; Fema | 2012 |
[Biological markers for the status of vitamins B12 and D: the importance of some analytical aspects in relation to clinical interpretation of results].
Topics: Biomarkers; Homocysteine; Humans; Methylmalonic Acid; Transcobalamins; Vitamin B 12; Vitamin B 12 De | 2012 |
Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
Topics: Aged; Apolipoprotein E4; Cognition; Cognition Disorders; Cross-Sectional Studies; Depression; Female | 2013 |
Laboratory evaluation for vitamin B12 deficiency: the case for cascade testing.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Female; Hemoglobins; Humans; Injections, Int | 2013 |
Serum cobalamin and methylmalonic acid concentrations in dogs with chronic gastrointestinal disease.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Chronic Disease; Dog Diseases; Dogs; Female; Gas Chro | 2013 |
Utility and limitations of biochemical markers of vitamin B12 deficiency.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Analysis of Variance; Biomarkers; Creatinine; Humans; Me | 2013 |
Vitamin B(12) intake and status in early pregnancy among urban South Indian women.
Topics: Adolescent; Adult; Anthropometry; Cross-Sectional Studies; Diet; Dietary Supplements; Erythrocytes; | 2013 |
Detection of vitamin B12 deficiency in alcohol abuse.
Topics: Alcohol Abstinence; Alcoholism; Homocysteine; Humans; Methylmalonic Acid; Optic Atrophy, Hereditary, | 2014 |
Independent effect of vitamin B12 deficiency on hematological status in older Chinese vegetarian women.
Topics: Aged; Anemia; Blood Cell Count; Blood Proteins; China; Cross-Sectional Studies; Diet, Vegetarian; Er | 2002 |
Is low-dose oral cobalamin enough to normalize cobalamin function in older people?
Topics: Administration, Oral; Aged; Aged, 80 and over; Cross-Sectional Studies; Dietary Supplements; Female; | 2002 |
Cobalamin disorder Cbl-C presenting with late-onset thrombotic microangiopathy.
Topics: Age of Onset; Child; Child, Preschool; Female; Hematinics; Hematuria; Hemolysis; Hemolytic-Uremic Sy | 2002 |
Elevated serum methylmalonic acid concentrations are common among elderly Americans.
Topics: Adult; Aged; Aging; Black or African American; Creatinine; Female; Folic Acid; Hispanic or Latino; H | 2002 |
Predictors of cobalamin deficiency in Guatemalan school children: diet, Helicobacter pylori, or bacterial overgrowth?
Topics: Analysis of Variance; Breath Tests; Child; Diet; Female; Gastrins; Guatemala; Helicobacter Infection | 2003 |
High prevalence of cobalamin deficiency in Guatemalan schoolchildren: associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations.
Topics: Analysis of Variance; Anemia; Biomarkers; Child; Creatinine; Female; Folic Acid; Guatemala; Hematocr | 2003 |
Vitamin B12 and methyl malonic acid: do we have all the answers?
Topics: Aged; Female; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2003 |
Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men.
Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Body Composition; Body Height; Body Weight; Bone De | 2003 |
Hypoxia-induced megaloblastosis in vitamin B12-deficient rats.
Topics: Analysis of Variance; Anemia, Megaloblastic; Animals; Erythrocyte Count; Erythropoietin; Hypoxia; Ma | 2003 |
Screening for vitamin B-12 and folate deficiency in older persons.
Topics: Age Factors; Aged; Aged, 80 and over; Creatinine; Female; Folic Acid; Folic Acid Deficiency; Hemoglo | 2003 |
Anemia, serum vitamin B12, and folic acid in patients with rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cohort Studies; | 2004 |
Urine methylmalonic acid measurements for the assessment of cobalamin deficiency related to neuropsychiatric disorders.
Topics: Adult; Aged; Folic Acid; Homocysteine; Humans; Mental Disorders; Methylmalonic Acid; Middle Aged; Ph | 2003 |
Increased plasma homocysteine levels without signs of vitamin B12 deficiency in patients with multiple sclerosis assessed by blood and cerebrospinal fluid homocysteine and methylmalonic acid.
Topics: Adult; Aged; Aged, 80 and over; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; | 2003 |
[Diagnosis of vitamin B 12 deficiency].
Topics: Biomarkers; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 2003 |
Myeloneuropathy from nitrous oxide abuse: unusually high methylmalonic acid and homocysteine levels.
Topics: Adult; Anesthetics, Inhalation; Demyelinating Diseases; Diagnosis, Differential; Homocysteine; Human | 2003 |
Reported symptoms and clinical findings in relation to serum cobalamin, folate, methylmalonic acid and total homocysteine among elderly Swedes: a population-based study.
Topics: Aged; Atrophy; Cohort Studies; Female; Folic Acid; Health Surveys; Homocysteine; Humans; Male; Methy | 2003 |
Challenges in the identification of cobalamin-deficiency polyneuropathy.
Topics: Adult; Aged; Aged, 80 and over; Anemia, Pernicious; Female; Follow-Up Studies; Homocysteine; Humans; | 2003 |
Methylmalonic acid excretion: an index of vitamin-B12 deficiency.
Topics: Anemia; Anemia, Macrocytic; Humans; Malonates; Methylmalonic Acid; Vitamin B 12 Deficiency; Vitamins | 1962 |
METHYLMALONIC ACID EXCRETION AND VITAMIN B12 DEFICIENCY IN THE HUMAN.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Carcinoma; Celiac Disease; Chromatography; Crohn Dis | 1964 |
Health technology assessment in clinical biochemistry. Methylmalonic acid: a Danish showcase.
Topics: Biomarkers; Clinical Chemistry Tests; Denmark; Humans; Methylmalonic Acid; Physicians; Professional | 2003 |
Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Diet, Vegetarian; Female; Folic Acid; Germany; Ho | 2003 |
Holotranscobalamin as a predictor of vitamin B12 status.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Female; Forecasting; Homocysteine; Humans; Male; Methylm | 2003 |
Breeding severely vitamin B12-deficient mice as model animals.
Topics: Animals; Body Weight; Diet; Disease Models, Animal; Liver; Male; Maternal Nutritional Physiological | 2004 |
Parenteral vitamin B12 therapy of hyperhomocysteinemia in end-stage renal disease.
Topics: Administration, Oral; Aged; Folic Acid; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Methy | 2004 |
Urinary methylmalonic acid test may have greater value than the total homocysteine assay for screening elderly individuals for cobalamin deficiency.
Topics: Aged; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 2004 |
Use of fasting urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older persons.
Topics: Aging; Biomarkers; Creatinine; Diet, Vegetarian; Fasting; Female; Folic Acid; Hong Kong; Humans; Kid | 2004 |
Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents.
Topics: Absorptiometry, Photon; Adolescent; Analysis of Variance; Anthropometry; Bone Density; Case-Control | 2005 |
Biochemical signs of impaired cobalamin status during and after radiotherapy for rectal cancer.
Topics: Adult; Aged; Biomarkers; Diarrhea; Female; Homocystine; Humans; Male; Methylmalonic Acid; Middle Age | 2004 |
Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Female; Health Maintenance Organizations; Homocysteine; | 2005 |
A population-based intervention study on elevated serum levels of methylmalonic acid and total homocysteine in elderly people: results after 36 months of follow-up.
Topics: Aged; Cohort Studies; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Longitudinal Stud | 2004 |
Cobalamin deficiency in elderly patients.
Topics: Aged; Algorithms; Canada; Folic Acid; Food, Fortified; Homocysteine; Humans; Methylmalonic Acid; Vit | 2005 |
The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings.
Topics: Adult; Age Factors; Aged; Biomarkers; Female; Humans; Kidney Failure, Chronic; Male; Methylmalonic A | 2005 |
Elevated methylmalonic acid is related to cognitive impairement in older adults enrolled in an elderly nutrition program.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Dietary Services; Epidemiologic Methods; Female; Food | 2005 |
Cobalamin-responsive disorders and unreliability of cobalamin, methylmalonic acid, and homocysteine testing.
Topics: Diagnostic Errors; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 2005 |
Maculopathy and retinal degeneration in cobalamin C methylmalonic aciduria and homocystinuria.
Topics: Amino Acid Metabolism, Inborn Errors; Betaine; Cobamides; Female; Homocysteine; Homocystinuria; Huma | 2005 |
Folate and vitamin B12 in relation to lactation: a 9-month postpartum follow-up study.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lactati | 2006 |
Vitamin B12 and homocysteine.
Topics: Biomarkers; Carotid Stenosis; Homocystine; Humans; Methylmalonic Acid; Reproducibility of Results; V | 2005 |
A daily intake of approximately 6 microg vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women.
Topics: Administration, Oral; Adult; Aged; Denmark; Diet; Diet Records; Dietary Supplements; Dose-Response R | 2006 |
Two newborns with nutritional vitamin B12 deficiency: challenges in newborn screening for vitamin B12 deficiency.
Topics: Acyl-CoA Dehydrogenase, Long-Chain; Anemia, Pernicious; Autoimmune Diseases; Biomarkers; Carnitine; | 2005 |
Cobalamin status during normal pregnancy and postpartum: a longitudinal study comprising 406 Danish women.
Topics: Adult; Cohort Studies; Denmark; Female; Follow-Up Studies; Hemoglobins; Homocysteine; Humans; Infant | 2006 |
[Oral treatment of vitamin B12 deficiency in subacute combined degeneration].
Topics: Administration, Oral; Adult; Anemia, Pernicious; Autoantibodies; Dose-Response Relationship, Drug; F | 2006 |
Abnormal increase in the expression level of proliferating cell nuclear antigen (PCNA) in the liver and hepatic injury in rats with dietary cobalamin deficiency.
Topics: Alanine Transaminase; Animals; Biomarkers; Body Weight; Carnitine; Cell Proliferation; Growth Disord | 2006 |
Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study.
Topics: Aged; Aged, 80 and over; Aging; Cognition; Cohort Studies; Cross-Sectional Studies; Female; Folic Ac | 2006 |
Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly.
Topics: Aged; Avitaminosis; Biomarkers; Creatinine; Cystatin C; Cystatins; Female; Folic Acid; Folic Acid De | 2007 |
Renal impairment compromises the use of total homocysteine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged.
Topics: Aged; Aged, 80 and over; Homocysteine; Humans; Kidney Diseases; Methods; Methylmalonic Acid; Transco | 2007 |
Holotranscobalamin and methylmalonic acid as prognostic markers following an acute myocardial infarction.
Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Female; Follow-Up Studies; Homocysteine; Humans; | 2008 |
Cobalamin deficiency-induced down-regulation of p75-immunoreactive cell levels in rat central nervous system.
Topics: Animals; Central Nervous System; Down-Regulation; Gastrectomy; Homocysteine; Immunohistochemistry; M | 2007 |
Changes in markers of cobalamin status after cessation of oral B-vitamin supplements in elderly people with mild cobalamin deficiency.
Topics: Aged, 80 and over; Biological Availability; Biomarkers; Dietary Supplements; Female; Folic Acid; Fol | 2008 |
Testicular injury to rats fed on soybean protein-based vitamin B12-deficient diet can be reduced by methionine supplementation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Animals; Body Weigh | 2007 |
West syndrome in an infant with vitamin B12 deficiency in the absence of macrocytic anaemia.
Topics: Anemia, Macrocytic; Brain; Diagnosis, Differential; Electroencephalography; Female; Homocysteine; Hu | 2007 |
Low vitamin B-12 status and risk of cognitive decline in older adults.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Cohort Studies; Female; Homocysteine; Humans; Longitud | 2007 |
In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations.
Topics: Adult; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Time Factors | 2007 |
Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acid.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methylmalonic Acid; Middle Aged; Transcobalami | 2007 |
Dietary patterns and vitamin B(12) status of migrant Indian preadolescent girls.
Topics: Child; Diet, Vegetarian; Female; Folic Acid; Humans; India; Methylmalonic Acid; New Zealand; Vitamin | 2009 |
Methylmalonic acid values in healthy Dutch children.
Topics: Adolescent; Adult; Aging; Biomarkers; Child; Child, Preschool; Creatinine; Cross-Sectional Studies; | 2008 |
Methylmalonic aciduria articles.
Topics: Humans; Metabolism, Inborn Errors; Methylmalonic Acid; Vitamin B 12 Deficiency | 2008 |
Neurologic complications of gastric bypass surgery for morbid obesity.
Topics: Blood Chemical Analysis; Central Nervous System; Copper; Dietary Supplements; Gastric Bypass; Humans | 2008 |
In vitamin B12 deficiency, higher serum folate is associated with increased homocysteine and methylmalonic acid concentrations.
Topics: Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 2008 |
Altered red cell membrane compositions related to functional vitamin B(12) deficiency manifested by elevated urine methylmalonic acid concentrations in patients with schizophrenia.
Topics: Adult; Erythrocyte Membrane; Female; Humans; Male; Methylmalonic Acid; Schizophrenia; Vitamin B 12 D | 2008 |
Effect of dietary and nitrous oxide-induced vitamin B-12 deficiency on uptake of 5-methyltetrahydrofolate by isolated rat hepatocytes.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Biological Transport; Cell Membr | 1980 |
Problems with vitamin B12 assays.
Topics: Folic Acid Deficiency; Humans; Malonates; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Metabolism of methylmalonic acid in rats. Is methylmalonyl-coenzyme a racemase deficiency symptomatic in man?
Topics: Animals; Chemical Phenomena; Chemistry; Isomerases; Isotope Labeling; Male; Malonates; Methylmalonic | 1983 |
Urinary methylmalonic acid excretion.
Topics: Humans; Malonates; Methylmalonic Acid; Vitamin B 12 Deficiency | 1983 |
Mitochondrial abnormalities in muscle from vitamin B12-deficient sheep.
Topics: Animals; Methylmalonic Acid; Mitochondria, Muscle; Sheep; Sheep Diseases; Vitamin B 12 Deficiency | 1983 |
Cobalamin (vitamin B12) deficiency detection by urinary methylmalonic acid quantitation.
Topics: Adult; Aged; Female; Humans; Male; Malonates; Methylmalonic Acid; Middle Aged; Vitamin B 12; Vitamin | 1982 |
Simple estimation of urinary methylmalonic acid by isotachophoretic analysis.
Topics: Electrophoresis; Humans; Malonates; Methylmalonic Acid; Vitamin B 12 Deficiency | 1980 |
Relationship of urinary methylmalonic acid to vitamin B-12 concentrations and hematologic changes in rats fed vitamin B-12-deficient diets.
Topics: Animals; Body Weight; Bone Marrow; Brain; Hematocrit; Hemoglobins; Liver; Male; Malonates; Methylmal | 1980 |
Metabolism of valine chirally labeled with carbon 13 and deuterium in vitamin B12-folate-deficient rats in vivo. Studies on the physiological role of keto-enol tautomerization.
Topics: Animals; Butyrates; Carbon Isotopes; Deuterium; Folic Acid Deficiency; Isobutyrates; Isomerism; Isot | 1980 |
Methylmalonic acid inhibits respiration in rat liver mitochondria.
Topics: Adenosine Diphosphate; Animals; Cell Fractionation; Chromatography, High Pressure Liquid; Energy Met | 1995 |
Excretion from rats of ketone bodies and methylmalonic acid in urine resulting from dietary vitamin B12 deficiency.
Topics: Animals; Chromatography, High Pressure Liquid; Hydroxocobalamin; Ketone Bodies; Male; Methylmalonic | 1995 |
[Development regression in a child caused by vitamin B12 deficiency].
Topics: Adult; Developmental Disabilities; Female; Humans; Infant; Methylmalonic Acid; Vitamin B 12; Vitamin | 1994 |
[B12 deficiency in breast-fed children. Maternal deficiency may cause severe symptoms in children].
Topics: Breast Feeding; Female; Humans; Infant; Infant, Newborn; Male; Malonates; Methylmalonic Acid; Vitami | 1995 |
Biochemical indices of vitamin B12 nutrition in pregnant patients with subnormal serum vitamin B12 levels.
Topics: Female; Homocysteine; Humans; Methylmalonic Acid; Nutritional Status; Pregnancy; Pregnancy Complicat | 1995 |
Urinary methylmalonic acid to detect vitamin B12 deficiency.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1995 |
Urinary methylmalonic acid and cobalamin deficiency in the elderly.
Topics: Aged; Diagnosis, Differential; Humans; Methylmalonic Acid; Predictive Value of Tests; Vitamin B 12 D | 1995 |
Neuropathic bladder in setting of severe vitamin B12 deficiency: a case report.
Topics: Aged; Female; Homocysteine; Humans; Methylmalonic Acid; Movement Disorders; Sensation Disorders; Uri | 1995 |
[Neonatal hemolytic and uremic syndrome, methylmalonic aciduria and homocystinuria due to intracellular vitamin B12 deficiency].
Topics: Hemolytic-Uremic Syndrome; Homocystinuria; Humans; Infant; Infant, Newborn; Methylmalonic Acid; Vita | 1994 |
Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe.
Topics: Anemia, Megaloblastic; Anemia, Pernicious; Erythrocyte Indices; Female; Folic Acid; Folic Acid Defic | 1994 |
Cobalt-vitamin B12 deficiency causes accumulation of odd-numbered, branched-chain fatty acids in the tissues of sheep.
Topics: Animals; Brain; Cobalt; Fatty Acids; Kidney; Liver; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Sh | 1994 |
Guidelines on the investigation and diagnosis of cobalamin and folate deficiencies. A publication of the British Committee for Standards in Haematology. BCSH General Haematology Test Force.
Topics: Blood Cell Count; Bone Marrow Examination; Deoxyuridine; Folic Acid Deficiency; Homocysteine; Humans | 1994 |
Serum cobalamin deficiency is uncommon in multiple sclerosis.
Topics: Adult; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; Multiple Sclerosis; Muscular Diseases; | 1994 |
Screening for vitamin B12 deficiency in psychiatric patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Homocysteine; Humans; Male; Mental Disorders; Me | 1994 |
Prevalence of cobalamin deficiency in the Framingham elderly population.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cohort Studies; Female; Folic Acid Deficiency; Gas Chromatogr | 1994 |
Quantification of methylmalonic acid in serum measured by capillary gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives.
Topics: Adolescent; Adult; Child; Child, Preschool; Dimethylformamide; Gas Chromatography-Mass Spectrometry; | 1993 |
Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies.
Topics: Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylmalonic Acid; Predictive Value of T | 1994 |
Determination of methylmalonic acid by high-performance liquid chromatography.
Topics: Animals; Body Fluids; Cadaverine; Chemistry Techniques, Analytical; Chromatography, High Pressure Li | 1994 |
Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin.
Topics: Aged; Aged, 80 and over; Diagnosis, Differential; Female; Homocysteine; Humans; Intestinal Absorptio | 1993 |
Serum cobalamin and methylmalonic acid in Alzheimer dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Diagnosis, Differential; Erythrocyte In | 1993 |
Effect of vitamin B12 status on selenium methylation and toxicity in rats: in vivo and in vitro studies.
Topics: Animals; In Vitro Techniques; Liver; Male; Methylation; Methylmalonic Acid; Rats; Rats, Sprague-Dawl | 1993 |
Automated assay of methylmalonic acid in serum and urine by derivatization with 1-pyrenyldiazomethane, liquid chromatography, and fluorescence detection.
Topics: Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Fluor | 1993 |
Detection of cobalamin deficiency using the urinary methylmalonic acid test by gas chromatography mass spectrometry.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1993 |
Vitamin B12 deficiency.
Topics: Aged; Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1993 |
Screening elderly populations for cobalamin (vitamin B12) deficiency using the urinary methylmalonic acid assay by gas chromatography mass spectrometry.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Female; Gas Chromatography-Mass Spectrometry; Humans; | 1993 |
Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency.
Topics: Adolescent; Adult; Aged; Female; Folic Acid; Folic Acid Deficiency; Half-Life; Hematinics; Homocyste | 1996 |
Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin B12 deficiency after gastric surgery.
Topics: Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Homocysteine; Humans; Male; Methylm | 1996 |
MMA test to detect vitamin B12 deficiency.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Methylmalonic Acid; Sensitivity and Specificity; Vitam | 1996 |
The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency.
Topics: Adolescent; Adult; Aged; Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylmalonic Ac | 1996 |
Methylmalonic acid quantification by stable isotope dilution gas chromatography-mass spectrometry from filter paper urine samples.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Deuterium; Gas Chr | 1996 |
Accumulation of methylmalonic acid caused by vitamin B12-deficiency disrupts normal cellular metabolism in rat liver.
Topics: Animals; Carbon; Cells, Cultured; Glucose; Glutamic Acid; Growth Disorders; Liver; Male; Methylmalon | 1996 |
Utilization of dietary protein in the vitamin B12-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Proteins; Dietary Proteins; Male; Methylm | 1995 |
Effect of N2O treatment/vitamin B12 deficiency in pigs on tissue concentrations of odd-numbered, branched-chain fatty acids.
Topics: Animals; Brain; Fatty Acids; Kidney; Liver; Methylmalonic Acid; Methylmalonyl-CoA Mutase; Myocardium | 1995 |
Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women.
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; H | 1996 |
Vitamin B12 deficiency after gastric surgery: its early detection.
Topics: Homocysteine; Humans; Methylmalonic Acid; Peptic Ulcer; Postoperative Complications; Stomach; Vitami | 1996 |
Cobalamin and folate deficiencies.
Topics: Biomarkers; Chemistry, Clinical; Folic Acid; Folic Acid Deficiency; Hematology; Homocysteine; Humans | 1996 |
[Homocysteine and methylmalonic acid. New tests--for what benefit?].
Topics: Amino Acids; Evaluation Studies as Topic; Homocysteine; Humans; Mass Screening; Methylmalonic Acid; | 1996 |
Alcoholic cirrhosis and cobalamin metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Biomarkers; Biopsy, Needle; | 1997 |
Plasma methylmalonic acid in relation to serum cobalamin and plasma homocysteine in a psychogeriatric population and the effect of cobalamin treatment.
Topics: Aged; Biomarkers; Case-Control Studies; Drug Monitoring; Female; Geriatric Psychiatry; Homocysteine; | 1997 |
Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease?
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Female; Folic Acid Deficiency; Homocysteine; Hosp | 1997 |
Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Pernicious; Animals; Bacteria, An | 1997 |
Home parenteral nutrition and vitamin B12 status.
Topics: Adult; Aged; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; Nutritional Status | 1997 |
Diagnosis of cobalamin deficiency: the old and the new.
Topics: Erythrocyte Volume; Hematologic Tests; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12; Vitam | 1997 |
Vitamin B-12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum.
Topics: Adult; Anthropometry; Female; Guatemala; Humans; Infant; Lactation; Methylmalonic Acid; Milk, Human; | 1997 |
[Megaloblastic anemia: rapid and economical study].
Topics: Adolescent; Adult; Algorithms; Anemia, Megaloblastic; Cost Control; Diagnosis, Differential; Diagnos | 1997 |
Serum methylmalonic acid and total homocysteine in patients with suspected cobalamin deficiency: a clinical study based on gastrointestinal histopathological findings.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Female; Gastric Mucosa; Homocysteine; Humans; Intestinal | 1997 |
Urinary methylmalonic acid/creatinine ratio defines true tissue cobalamin deficiency.
Topics: Creatinine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1998 |
Methylmalonic acid as a marker for cobalamin deficiency: fact or fantasy? Elucidations from the cobalamin-deficient rat.
Topics: Animals; Methylmalonic Acid; Rats; Vitamin B 12 Deficiency | 1998 |
Serum C3 content in vitamin B(12)-deficient rats.
Topics: Animals; Blood Proteins; Complement C3; Diet; Male; Methylmalonic Acid; Rats; Rats, Wistar; Vitamin | 1998 |
Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects.
Topics: Aged; Aged, 80 and over; Female; Gastritis, Atrophic; Helicobacter Infections; Helicobacter pylori; | 1998 |
The effect of vitamin B12 deficiency on older veterans and its relationship to health.
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Analysis of Variance; Cognition Disorders; Cross-Sectiona | 1998 |
Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.
Topics: Adult; Aged; Algorithms; Diagnosis, Differential; Female; Gastrins; Gastritis, Atrophic; Homocystein | 1998 |
[Functional deficiency of vitamin B12 and folate. No "parameter" is "meter"].
Topics: Biomarkers; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Specimen Handling; Vita | 1998 |
Cobalamin deficiency in general practice. Assessment of the diagnostic utility and cost-benefit analysis of methylmalonic acid determination in relation to current diagnostic strategies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cohort Studies; Cost-Benefit An | 1999 |
Prevalence of subtle cobalamin deficiency.
Topics: Aged; Aged, 80 and over; Female; Humans; Male; Methylmalonic Acid; Prevalence; Vitamin B 12; Vitamin | 1999 |
Risk of persistent cobalamin deficiency in adolescents fed a macrobiotic diet in early life.
Topics: Adolescent; Anthropometry; Case-Control Studies; Child; Diet, Macrobiotic; Female; Follow-Up Studies | 1999 |
Holotranscobalamin - a sensitive marker of cobalamin malabsorption.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Atrophy; Female; Gastric Mucosa; Homocysteine; Humans; I | 1999 |
Turn of tide for oral vitamin B12 treatment.
Topics: Administration, Oral; Aged; Biological Availability; Biomarkers; England; Female; Homocysteine; Huma | 1999 |
Urinary methylmalonic acid/creatinine ratio: a gold standard test for tissue vitamin B12 deficiency.
Topics: Aged; Creatinine; Humans; Methylmalonic Acid; Sensitivity and Specificity; Veterans; Vitamin B 12; V | 1999 |
Schilling and protein-bound cobalamin absorption tests are poor instruments for diagnosing cobalamin malabsorption.
Topics: Adult; Atrophy; Duodenum; Female; Homocysteine; Humans; Intestinal Absorption; Male; Methylmalonic A | 1997 |
Transcobalamin II deficiency with methylmalonic aciduria in three sisters.
Topics: Cells, Cultured; Female; Fibroblasts; Follow-Up Studies; Humans; Infant; Infant, Newborn; Ketosis; M | 1999 |
Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities.
Topics: Aged; Analysis of Variance; Ethnicity; Female; Folic Acid; Homocysteine; Humans; Los Angeles; Male; | 1999 |
Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women.
Topics: Aged; Aged, 80 and over; Black People; Cross-Sectional Studies; Disabled Persons; Educational Status | 1999 |
Comparison of serum and plasma methylmalonic acid measurements in 13 laboratories: An international study.
Topics: Calibration; Gas Chromatography-Mass Spectrometry; Humans; Laboratories; Methylmalonic Acid; Quality | 1999 |
Evaluation of low serum vitamin B(12) in the non-anaemic pregnant patient.
Topics: Adult; Erythrocyte Indices; Female; Gestational Age; Homocysteine; Humans; Methylmalonic Acid; Parit | 2000 |
Relationship between methylmalonic acid and cobalamin in uremia.
Topics: Adult; Aged; Female; Humans; Male; Methylmalonic Acid; Middle Aged; Renal Dialysis; Uremia; Vitamin | 2000 |
Using homocysteine and related metabolites to diagnose vitamin deficiency states.
Topics: Aging; Animals; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Defici | 2000 |
Physicians' use of plasma methylmalonic acid as a diagnostic tool.
Topics: Adult; Aged; Aged, 80 and over; Decision Making; Diagnosis, Differential; Female; Humans; Male; Meth | 2000 |
The marker of cobalamin deficiency, plasma methylmalonic acid, correlates to plasma creatinine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Child; Child, Preschool; Creatinine; Cross-S | 2000 |
Etiology and diagnostic evaluation of macrocytosis.
Topics: Adult; Aged; Alcohol Drinking; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow Diseases; Diag | 2000 |
Inhibition of vitamin B12 metabolism by OH-cobalamin c-lactam in rat oligodendrocytes in culture: a model for studying neuropathy due to vitamin B12 deficiency.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media, Conditioned; Homocysteine; Humans; Methyl | 2000 |
Extremely low activity of methionine synthase in vitamin B-12-deficient rats may be related to effects on coenzyme stabilization rather than to changes in coenzyme induction.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cells, Cultured; Enzyme Stabilit | 2000 |
Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Circulation; Dementia, Vascular; Female; | 2000 |
[Evaluation of analytic test methods. Stomach-intestines status is the best diagnostic method in suspected vitamin B12 deficiency].
Topics: Biomarkers; Gastric Mucosa; Gastritis, Atrophic; Gastrointestinal Diseases; Gastroscopy; Homocystein | 2000 |
Evaluation of indicators of cobalamin deficiency defined as cobalamin-induced reduction in increased serum methylmalonic acid.
Topics: Adolescent; Aged; Aged, 80 and over; Female; Folic Acid; Gastroscopy; Homocysteine; Humans; Male; Me | 2000 |
Vitamin B12 deficiency and incontinence in older people.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Homocysteine; Humans; Male; Methylmalonic | 2000 |
Oral contraceptives can cause falsely low vitamin B(12) levels.
Topics: Adult; Contraceptives, Oral; Diagnostic Errors; False Positive Reactions; Female; Homocysteine; Huma | 2000 |
Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects.
Topics: Adult; Aged; Cystathionine; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Kidney; | 2000 |
Metabolic vitamin B12 status on a mostly raw vegan diet with follow-up using tablets, nutritional yeast, or probiotic supplements.
Topics: Administration, Sublingual; Diet; Diet, Vegetarian; Dietary Supplements; Female; Humans; Male; Methy | 2000 |
Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Atrophy; Brain; Brain Diseases, Metabolic | 2001 |
[Regarding the diagnosis of vitamin B 12 deficiency].
Topics: Age Factors; Biomarkers; Homocysteine; Humans; Methylmalonic Acid; Reference Values; Vitamin B 12 De | 2001 |
[Study of cobalamin deficiency in gastrectomized and aged subjects].
Topics: Age Factors; Aged; Creatinine; Data Interpretation, Statistical; Gastrectomy; Homocysteine; Humans; | 2001 |
Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status.
Topics: Animals; Biological Availability; Biomarkers; Body Weight; Liver; Male; Methylmalonic Acid; Rats; Ra | 2001 |
Characterization of a vitamin B12 compound from unicellular coccolithophorid alga (Pleurochrysis carterae).
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eukaryota; Methylmalonic Acid; Rats; | 2001 |
Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Diet, Vegetarian; Female; Folic Acid; | 2001 |
Shifts in B12 opinions in primary health care of Sweden.
Topics: Attitude of Health Personnel; Biomarkers; Clinical Competence; Decision Making; Homocysteine; Humans | 2001 |
Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy.
Topics: Adult; Biomarkers; Female; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Pregnanc | 2001 |
Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered?
Topics: Adolescent; Adult; Biomarkers; Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Fol | 2001 |
High prevalence of low serum vitamin B12 in a multi-ethnic Israeli population.
Topics: Adult; Arabs; Blood Donors; Case-Control Studies; Chi-Square Distribution; Female; Gaucher Disease; | 2001 |
Metabolism of amino acids in cats with severe cobalamin deficiency.
Topics: Amino Acids; Animals; Cat Diseases; Cats; Cystathionine; Cysteine; Female; Gastrointestinal Diseases | 2001 |
Vitamin B12 metabolism after urinary diversion with a Kock ileal reservoir.
Topics: Adult; Aged; Female; Follow-Up Studies; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged; | 2001 |
Methylmalonic acid and clinical practice.
Topics: Humans; Methylmalonic Acid; Practice Patterns, Physicians'; Predictive Value of Tests; Vitamin B 12 | 2002 |
[Metabolic complications and neurologic manifestations of vitamin B12 deficiency in children of vegetarian mothers].
Topics: Anemia, Megaloblastic; Brain; Breast Feeding; Developmental Disabilities; Diet, Vegetarian; Failure | 2001 |
[Methylmalonic acid in diagnosis of vitamin B12 deficiency].
Topics: Biomarkers; Homocysteine; Humans; Methylmalonic Acid; Reference Values; Vitamin B 12 Deficiency | 2002 |
The pathogenesis of hydrocephalus in inborn errors of the single carbon transfer pathway.
Topics: Cerebrospinal Fluid; Homocystinuria; Humans; Hydrocephalus; Infant; Methylenetetrahydrofolate Reduct | 2001 |
[Diagnosis and vitamin B12 deficiency].
Topics: Biomarkers; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 2001 |
Reversible myelopathy in a 34-year-old man with vitamin B12 deficiency.
Topics: Adult; Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Male; Methylmalonic Acid; Parest | 2002 |
Vitamin B(12) deficiency associated with histamine(2)-receptor antagonists and a proton-pump inhibitor.
Topics: Aged; Cimetidine; Creatinine; Enzyme Inhibitors; Female; Folic Acid; Gastroesophageal Reflux; Histam | 2002 |
Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients.
Topics: Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Genotype; H | 2002 |
Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake.
Topics: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Geriatrics; Hematocrit; Humans; Male; Mass | 2002 |
Early-onset cobalamin C/D deficiency: epilepsy and electroencephalographic features.
Topics: Age of Onset; Brain; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Homocysteine; Homo | 2002 |
Vitamin B12 and folate after 5-12 years of continent ileal urostomy (Kock reservoir) in children and adolescents.
Topics: Adolescent; Child; Child Welfare; Colonic Pouches; Female; Folic Acid; Folic Acid Deficiency; Follow | 2002 |
Use of plasma methylmalonic acid in diagnosing vitamin B-12 deficiency in general practice.
Topics: Adult; Aged; Aged, 80 and over; Creatinine; Erythrocyte Indices; Erythrocytes; Family Practice; Fema | 2002 |
Serum acylcarnitines and vitamin B12 deficiency.
Topics: Aged; Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Male; Mass Spectrometry; Meth | 2002 |
Transcobalamin II 775G>C polymorphism and indices of vitamin B12 status in healthy older adults.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Female; Homocysteine; Humans; Male; Methylmalonic Acid; | 2002 |
Selective inactivation of vitamin B12 in rats by nitrous oxide.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cytosol; Liver; Methylmalonic Ac | 1978 |
Urinary methylmalonic acid as an indicator of the vitamin B12 status of grazing sheep.
Topics: Animals; Cobalt; Malonates; Methylmalonic Acid; Sheep; Sheep Diseases; Vitamin B 12 Deficiency | 1979 |
Effect of dietary thyroid powder on urinary excretion of formiminoglutamic acid and methylmalonic acid.
Topics: Animals; Dietary Proteins; Folic Acid; Formiminoglutamic Acid; Glutarates; Histidine; Male; Malonate | 1979 |
Dietary fiber and vitamin B12 balance.
Topics: Animals; Body Weight; Cellulose; Dietary Fiber; Feces; Intestinal Absorption; Methylmalonic Acid; Pe | 1979 |
Congenital defect in intracellular cobalamin metabolism resulting in homocysteinuria and methylmalonic aciduria. I. Case report and histopathology.
Topics: Blood Vessels; Homocystinuria; Humans; Infant; Kidney; Lung; Male; Malonates; Metabolism, Inborn Err | 1979 |
Methylmalonic acid metabolism of germfree and conventional vitamin B-12 deprived rats fed precursors of methylmalonate.
Topics: Animals; Dietary Proteins; Germ-Free Life; Glycine max; Male; Malonates; Methylmalonic Acid; Propion | 1979 |
[Water-soluble vitamins in therapy: cobalamins].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Cobamides; Humans; Malonates; Metabolism, Inborn Errors; | 1977 |
Methylmalonic acid and vitamin B12 excretion of rats consuming diets varying in cellulose and pectin.
Topics: Animals; Cellulose; Dietary Fiber; Feces; Male; Malonates; Methylmalonic Acid; Pectins; Rats; Vitami | 1978 |
A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Anemia, Megaloblastic; Breast Feeding; Diagnosis, Diffe | 1978 |
Increased concentration of transcobalamin I in a patient with metastatic carcinoma of the breast.
Topics: Blood Proteins; Breast Neoplasms; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis | 1978 |
A biochemical study of vitamin B12 deficiency in the baboon.
Topics: Ampicillin; Animals; Ascorbic Acid; Brain; Depression, Chemical; Diet; Glutathione; Haplorhini; Lipi | 1975 |
Applicability of an enzymatic quantitation of methylmalonic, propionic, and acetic acids in normal and megaloblastic states.
Topics: Acetates; Anemia, Megaloblastic; Animals; Clinical Enzyme Tests; Folic Acid Deficiency; Humans; Malo | 1977 |
Neonatal acidosis associated with transient methylmalonicaciduria and vitamin B12 deficiency.
Topics: Acid-Base Equilibrium; Acidosis; Humans; Infant, Newborn; Malonates; Metabolism, Inborn Errors; Meth | 1977 |
Methylmalonic aciduria in the newborn.
Topics: Breast Feeding; Follow-Up Studies; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Malon | 1976 |
Erythrocyte glutathione metabolism in cobalt-deficient goats.
Topics: Anemia, Macrocytic; Animal Feed; Animals; Cobalt; Erythrocytes; Female; Glutathione; Glutathione Per | 1976 |
Vitamin B12 nutrition and metabolism in the baboon (Papio cynocephalus).
Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Proteins; Cobalt Radioisotopes; Diet, Veg | 1975 |
Experimental vitamin B12 deficiency in the baboon.
Topics: Animals; Bacteria; Biopsy; Blood Cell Count; Brain Chemistry; Cerebral Cortex; Folic Acid; Formimino | 1975 |
Cardiac structure and function in vitamin B-12-deprived rats.
Topics: Animals; Fatty Acids; Female; Maternal-Fetal Exchange; Methylmalonic Acid; Mitochondria, Muscle; Myo | 1975 |
Prevalence of vitamin B12 deficiency among geriatric outpatients.
Topics: Aged; Aged, 80 and over; Female; Gastritis, Atrophic; Homocysteine; Humans; Male; Methylmalonic Acid | 1992 |
Cobalamin deficiency associated with methylmalonic acidemia in a cat.
Topics: Absorption; Amino Acid Metabolism, Inborn Errors; Amino Acids; Animals; Cat Diseases; Cats; Dietary | 1992 |
[Determination of methyl malonate--a new way for indication of cobalamin deficiency].
Topics: Humans; Mass Spectrometry; Methylmalonic Acid; Vitamin B 12 Deficiency | 1992 |
Serum methylmalonic acid before and after oral L-isoleucine loading in cobalamin-deficient patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Female; Humans; Isoleucine; Male; Methylmaloni | 1992 |
Serum methylmalonic acid in uraemia.
Topics: Adolescent; Adult; Aged; Child; Creatinine; Female; Humans; Male; Methylmalonic Acid; Middle Aged; R | 1992 |
High prevalence of cobalamin deficiency in elderly outpatients.
Topics: Aged; Aged, 80 and over; Ambulatory Care; Colorado; Female; Homocysteine; Humans; Male; Mass Screeni | 1992 |
[Laboratory diagnosis of cobalamin deficiency. A comparative study of 2 serum cobalamin methods and serum methylmalonic acid].
Topics: Adolescent; Adult; Aged; Chemistry, Clinical; Female; Humans; Male; Methylmalonic Acid; Middle Aged; | 1992 |
[Cobalamin deficiency despite normal serum cobalamins].
Topics: Aged; Chemistry, Clinical; Humans; Male; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 1992 |
Reversal by cobalamin therapy of minimal defects in the deoxyuridine suppression test in patients without anemia: further evidence for a subtle metabolic cobalamin deficiency.
Topics: Aged; Aged, 80 and over; Anemia; Bone Marrow; Deoxyuridine; DNA; Female; Humans; Male; Methylmalonic | 1992 |
Ocular histopathologic characteristics of cobalamin C type vitamin B12 defect with methylmalonic aciduria and homocystinuria.
Topics: Eye; Eye Diseases; Female; Homocystinuria; Humans; Infant; Iris Diseases; Methylmalonic Acid; Pigmen | 1992 |
Methylmalonic acid concentration in serum not affected in hepatic disease.
Topics: Acute Disease; Adult; Aged; Female; Hepatitis; Hepatitis, Chronic; Humans; Liver Cirrhosis; Liver Di | 1992 |
Nutritional vitamin B12 deficiency: two cases detected by routine newborn urinary screening.
Topics: Breast Feeding; Female; Humans; Infant; Infant, Newborn; Male; Methylmalonic Acid; Mothers; Neonatal | 1992 |
Decreased activities of ubiquinol:ferricytochrome c oxidoreductase (complex III) and ferrocytochrome c:oxygen oxidoreductase (complex IV) in liver mitochondria from rats with hydroxycobalamin[c-lactam]-induced methylmalonic aciduria.
Topics: Animals; Electron Transport; Electron Transport Complex III; Electron Transport Complex IV; Male; Me | 1991 |
Methylmalonic acid metabolism and nervous-system fatty acids in cobalamin-deficient fruit bats receiving supplements of methionine, valine and isoleucine.
Topics: Amino Acids; Animals; Brain; Chiroptera; Fatty Acids; Isoleucine; Liver; Methionine; Methylmalonic A | 1991 |
Rumen succinate production may ameliorate the effects of cobalt-vitamin B-12 deficiency on methylmalonyl CoA mutase in sheep.
Topics: Absorption; Androstadienes; Animals; Cobalt; Fluticasone; Gluconeogenesis; Methylmalonic Acid; Methy | 1991 |
Pathophysiologic study on methylmalonic aciduria: decrease in liver high-energy phosphate after propionate loading in rats.
Topics: Adenosine Triphosphate; Animals; Citric Acid Cycle; Energy Metabolism; Liver; Male; Methylmalonic Ac | 1991 |
Increased hepatic mitochondrial capacity in rats with hydroxy-cobalamin[c-lactam]-induced methylmalonic aciduria.
Topics: Animals; Blotting, Northern; Carnitine O-Palmitoyltransferase; Citrate (si)-Synthase; DNA, Mitochond | 1990 |
Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep.
Topics: Animals; Blood Glucose; Cobalt; Half-Life; Methylmalonic Acid; Propionates; Sheep; Vitamin B 12; Vit | 1991 |
Inherited selective intestinal cobalamin malabsorption and cobalamin deficiency in dogs.
Topics: Animals; Dog Diseases; Dogs; Female; Genes, Recessive; Ileum; Intrinsic Factor; Malabsorption Syndro | 1991 |
Cerebrospinal fluid methylmalonic acid levels in normal subjects and patients with cobalamin deficiency.
Topics: Adult; Aged; Female; Humans; Male; Methylmalonic Acid; Middle Aged; Succinates; Succinic Acid; Vitam | 1991 |
1H NMR characterization of normal human cerebrospinal fluid and the detection of methylmalonic acid in a vitamin B12 deficient patient.
Topics: Adult; Aged; Female; Humans; Magnetic Resonance Spectroscopy; Male; Methylmalonic Acid; Middle Aged; | 1991 |
Vitamin B-12 deficiency increases the specific activities of rat liver NADH- and NADPH-linked aquacobalamin reductase isozymes involved in coenzyme synthesis.
Topics: Animals; Body Weight; Coenzymes; Isoenzymes; Liver; Male; Methylmalonic Acid; NADH, NADPH Oxidoreduc | 1991 |
Methylmalonyl-CoA mutase (EC 5.4.99.2) and methionine synthetase (EC 2.1.1.13) in the tissues of cobalt-vitamin B12 deficient sheep.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Brain; Cobalt; Diet; Kidney; Liv | 1990 |
Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency.
Topics: Adult; Breast Feeding; Diet, Vegetarian; Female; Homocysteine; Humans; Infant; Methionine; Methylmal | 1991 |
The clinical evaluation of cobalamin deficiency by determination of methylmalonic acid in serum or urine is not invalidated by the presence of heterozygous methylmalonic-acidaemia.
Topics: Adult; Female; Heterozygote; Humans; Male; Metabolism, Inborn Errors; Methylmalonic Acid; Middle Age | 1990 |
The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Male; Methylmalonic Acid; Middle Aged; Prospective S | 1990 |
Coenzyme A metabolism in vitamin B-12-deficient rats.
Topics: Animals; Blood Glucose; Chromatography, High Pressure Liquid; Coenzyme A; Diet; Hydroxocobalamin; Hy | 1990 |
Diagnosis of cobalamin deficiency I: usefulness of serum methylmalonic acid and total homocysteine concentrations.
Topics: Adolescent; Adult; Aged; Female; Folic Acid; Homocysteine; Humans; Methylmalonic Acid; Middle Aged; | 1990 |
Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations.
Topics: Adult; Aged; Celiac Disease; Child, Preschool; Female; Folic Acid; Homocysteine; Humans; Intestines; | 1990 |
Methylmalonic acid concentrations in serum of normal subjects: biological variability and effect of oral L-isoleucine loads before and after intramuscular administration of cobalamin.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Injections, Intramuscular; Isoleucine; Male; Malo | 1990 |
Methylmalonic acid in renal insufficiency: evidence of accumulation and implications for diagnosis of cobalamin deficiency.
Topics: Adult; Creatinine; False Positive Reactions; Female; Humans; Kidney Failure, Chronic; Male; Malonate | 1990 |
Clinical spectrum and diagnosis of cobalamin deficiency.
Topics: Bilirubin; Female; Folic Acid; Gastrins; Hematocrit; Homocysteine; Humans; L-Lactate Dehydrogenase; | 1990 |
Sequential changes in plasma methylmalonic acid and vitamin B12 in sheep eating cobalt-deficient grass.
Topics: Animals; Body Weight; Cobalt; Diet; Malonates; Methylmalonic Acid; Poaceae; Sheep; Vitamin B 12; Vit | 1989 |
Fermentable dietary fibers elevate urinary methylmalonate and decrease propionate oxidation in rats deprived of vitamin B-12.
Topics: Animals; Body Weight; Cellulose; Dietary Fiber; Fermentation; Intestines; Male; Malonates; Methylmal | 1989 |
Neomycin has no persistent sparing effect on vitamin B-12 status in pectin-fed rats.
Topics: Animals; Diet; Dietary Fiber; Fermentation; Intestinal Absorption; Intestines; Male; Methylmalonic A | 1989 |
Studies on methylmalonic acid in humans. I. Concentrations in serum and urinary excretion in normal subjects after feeding and during fasting, and after loading with protein, fat, sugar, isoleucine, and valine.
Topics: Adult; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Eating; Fasting; Female; Humans; Isole | 1989 |
Studies on methylmalonic acid in humans. II. Relationship between concentrations in serum and urinary excretion, and the correlation between serum cobalamin and accumulation of methylmalonic acid.
Topics: Adult; Aged; Female; Humans; Kidney; Male; Malonates; Methylmalonic Acid; Middle Aged; Statistics as | 1989 |
Methylmalonic acid in the diagnosis of cobalt deficiency in barley-fed lambs.
Topics: Animals; Body Weight; Cobalt; Diet; Female; Hordeum; Male; Malonates; Methylmalonic Acid; Sheep; Tim | 1989 |
[Significance of methylmalonic acid analysis in clinical tests].
Topics: Chromatography, Gas; Chromatography, Thin Layer; Colorimetry; Humans; Malonates; Methylmalonic Acid; | 1989 |
Solid-phase sample extraction for rapid determination of methylmalonic acid in serum and urine by a stable-isotope-dilution method.
Topics: Adult; Gas Chromatography-Mass Spectrometry; Humans; Indicator Dilution Techniques; Malonates; Methy | 1989 |
[Assessment of laboratory findings in megaloblastic anemia--measurement of serum vitamin B12 and methylmalonic acid].
Topics: Adult; Aged; Aged, 80 and over; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Male; Mal | 1989 |
Effect of vitamin B12-deficiency on the activity of hepatic cystathionine beta-synthase in rats.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Betaine-Homocysteine S-Methyltra | 1989 |
Biochemical evidence of asymptomatic vitamin B12 deficiency in children after ileal resection for necrotizing enterocolitis.
Topics: Child; Child, Preschool; Enterocolitis, Pseudomembranous; Homocysteine; Humans; Ileum; Methylmalonic | 1989 |
[Urinary methylmalonic acid excretion and clinical features in megaloblastic anemia due to vitamin B12 deficiency].
Topics: Adolescent; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Male; Malonates; | 1989 |
Hereditary defect of cobalamin metabolism (cblG mutation) presenting as a neurologic disorder in adulthood.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Diagnosis, Differential; Female; H | 1988 |
Effect of thiouracil in modifying folate function in severe vitamin B12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Carbon Dioxide; Diet; Folic Acid | 1988 |
Vitamin B12-responsive megaloblastic anemia, homocystinuria, and transient methylmalonic aciduria in cb1E disease.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Fibroblasts; Homocystinuria; Humans; Infant, Newborn; Mal | 1988 |
Carnitine metabolism in the vitamin B-12-deficient rat.
Topics: Acetylcarnitine; Animals; Body Weight; Carnitine; Fasting; Male; Methylmalonic Acid; Rats; Vitamin B | 1988 |
Effect of hypothyroidism on methylmalonate excretion and hepatic vitamin B-12 levels in rats.
Topics: Animals; Dietary Proteins; Folic Acid; Histidine; Hypothyroidism; Liver; Malonates; Methylmalonic Ac | 1988 |
Therapeutic approaches to cobalamin-C methylmalonic acidemia and homocystinuria.
Topics: Administration, Oral; Amino Acid Metabolism, Inborn Errors; Betaine; Carnitine; Child, Preschool; Fe | 1988 |
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.
Topics: Adolescent; Adult; Aged; Anemia; Anemia, Megaloblastic; Ataxia; Erythrocyte Indices; Erythrocytes; F | 1988 |
Methylmalonic acid as an indicator of vitamin B12 deficiency in grazing sheep.
Topics: Animals; Cobalt; Malonates; Methylmalonic Acid; Sheep; Sheep Diseases; Vitamin B 12; Vitamin B 12 De | 1987 |
Laboratory tests in the diagnosis of vitamin B12 (cobalamin) deficiency.
Topics: Bone Marrow; Deoxyuridine; Humans; Methylmalonic Acid; Schilling Test; Vitamin B 12; Vitamin B 12 De | 1986 |
Isotope-dilution assay for urinary methylmalonic acid in the diagnosis of vitamin B12 deficiency. A prospective clinical evaluation.
Topics: Aged; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Humans; Indicator Dilution Techniques | 1987 |
Quantitation of urinary methylmalonic acid by gas chromatography mass spectrometry and its clinical applications.
Topics: Aged; Anemia; Anemia, Megaloblastic; China; Humans; Malonates; Methylmalonic Acid; Middle Aged; Vita | 1987 |
New urinary methylmalonic acid test is a sensitive indicator of cobalamin (vitamin B12) deficiency: a solution for a major unrecognized medical problem.
Topics: Humans; Malonates; Methylmalonic Acid; Vitamin B 12 Deficiency | 1987 |
Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry.
Topics: Adolescent; Adult; Aged; Anemia, Pernicious; Female; Folic Acid; Gas Chromatography-Mass Spectrometr | 1986 |
Methylmalonic aciduria in an infant of a mother with undiagnosed pernicious anaemia.
Topics: Anemia, Pernicious; Female; Humans; Infant, Newborn; Male; Malonates; Methylmalonic Acid; Vitamin B | 1987 |
Benign methylmalonic aciduria.
Topics: Adult; Aged; Child; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Humans; Malonates; Me | 1985 |
Retinal degeneration in vitamin B12 disorder associated with methylmalonic aciduria and sulfur amino acid abnormalities.
Topics: Amino Acids, Sulfur; Cystathionine; Humans; Malonates; Methylmalonic Acid; Retinal Degeneration; Vit | 1985 |
Vitamin B12 deficiency in the elderly.
Topics: Aged; Humans; Malonates; Methylmalonic Acid; Vitamin B 12 Deficiency | 1985 |
Cisplatin neurotoxicity: failure to demonstrate vitamin B12 inactivation.
Topics: Analysis of Variance; Circadian Rhythm; Cisplatin; Cobamides; Female; Homocysteine; Humans; Infusion | 1985 |
Vitamin B12 deficiency and the excretion of ether-soluble acids in the rat.
Topics: Acids; Animals; Female; Male; Malonates; Methylmalonic Acid; Rats; Rats, Inbred Strains; Vitamin B 1 | 1967 |