methylmalonic acid has been researched along with Deficiency, Folic Acid in 61 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The association of moderate hyperhomocysteinemia (HHcy) (15-30 μmol/L) with cardiovascular diseases (CVD) has been challenged by the lack of benefit of vitamin supplementation to lowering homocysteine." | 8.02 | Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients. ( Guéant, JL; Jeannesson, E; Levy, J; Oussalah, A; Rodriguez-Guéant, RM; Wahl, D; Ziuly, S, 2021) |
| "Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration." | 7.78 | Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. ( Brosnan, JT; Brosnan, ME; Lamarre, SG; Molloy, AM; Reinke, SN; Sykes, BD, 2012) |
| "The association of moderate hyperhomocysteinemia (HHcy) (15-30 μmol/L) with cardiovascular diseases (CVD) has been challenged by the lack of benefit of vitamin supplementation to lowering homocysteine." | 4.02 | Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients. ( Guéant, JL; Jeannesson, E; Levy, J; Oussalah, A; Rodriguez-Guéant, RM; Wahl, D; Ziuly, S, 2021) |
| "Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration." | 3.78 | Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. ( Brosnan, JT; Brosnan, ME; Lamarre, SG; Molloy, AM; Reinke, SN; Sykes, BD, 2012) |
| "To explore the dependence of glomerular filtration rate (GFR) on plasma total homocysteine (tHcy) and serum methylmalonic acid (MMA), as well as the consequences for the diagnosis of cobalamin and/or folic acid deficiency in an elderly community-dwelling population." | 3.74 | Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly. ( Lewerin, C; Ljungman, S; Nilsson-Ehle, H, 2007) |
| "Hyperhomocysteinemia, a well-recognized cardiovascular risk factor, is frequent in hemodialysis (HD) patients." | 3.71 | Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients. ( Funamizu, M; Hata, A; Hayashi, K; Hiejima, Y; Hirayama, H; Kawabata, M; Makita, Y; Nakamura, T; Saionji, K; Tago, K; Tajiri, M; Takano, H, 2002) |
| "Vitamin B12 deficiency is common in certain populations, such as in India, where there is also a rising prevalence of Type 2 diabetes, obesity and their complications." | 2.50 | The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity. ( Finer, S; Hitman, G; Saravanan, P; Yajnik, C, 2014) |
| "Vitamin B12 deficiency is neither correlated with the time elapsed since surgery, nor with the ileum length." | 1.31 | Vitamin B12 and folate after 5-12 years of continent ileal urostomy (Kock reservoir) in children and adolescents. ( Abd-el-Gawa, G; Abrahamsson, K; Hanson, E; Hjälmås, K; Norlén, L, 2002) |
| "Evaluation for the diagnosis of Alzheimer's disease, routine laboratory tests, serum folate and vitamin B-12, serum methylmalonic acid (MMA), total homocysteine (tHcy), and radiological tests was performed in 52 patients with Alzheimer's disease (AD), 50 nondemented hospitalized controls, and 49 healthy elderly subjects living at home." | 1.30 | Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? ( Dejaeger, E; Dereymaeker, L; Ghekiere, V; Joosten, E; Lesaffre, E; Pelemans, W; Riezler, R, 1997) |
| " The dosage of these two substances help to differenciate between both carencies, but it is not determinant of any of them and is an expensive method." | 1.30 | [Megaloblastic anemia: rapid and economical study]. ( Cicchetti, G; Marín, GH; Tentoni, J, 1997) |
| "Neurological dysfunction due to vitamin B12 deficiency is most prominent in patients with mild to moderate anaemia." | 1.29 | Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe. ( Bennie, A; Gangaidzo, I; Gwanzura, C; Kiire, C; Lindenbaum, J; Moyo, A; Mudenge, B; Mukiibi, JM; Savage, D; Sitima, J, 1994) |
| "Methylmalonic acid was elevated in 12." | 1.29 | Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. ( Allen, RH; Lindenbaum, J; Savage, DG; Stabler, SP, 1994) |
| "Methylmalonic acid was assayed by converting it to propionate by heat decarboxylation and then measuring the propionate increment over the endogenous amount in the noncarboxylated sample." | 1.26 | Applicability of an enzymatic quantitation of methylmalonic, propionic, and acetic acids in normal and megaloblastic states. ( Frenkel, EP; Kitchens, RL, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (11.48) | 18.7374 |
| 1990's | 16 (26.23) | 18.2507 |
| 2000's | 25 (40.98) | 29.6817 |
| 2010's | 10 (16.39) | 24.3611 |
| 2020's | 3 (4.92) | 2.80 |
| Authors | Studies |
|---|---|
| Mazokopakis, EE | 1 |
| Choi, R | 1 |
| Oh, Y | 1 |
| Park, MJ | 1 |
| Kim, S | 1 |
| Kim, Y | 1 |
| Lee, SG | 1 |
| Lee, EH | 1 |
| Levy, J | 1 |
| Rodriguez-Guéant, RM | 1 |
| Oussalah, A | 1 |
| Jeannesson, E | 1 |
| Wahl, D | 1 |
| Ziuly, S | 1 |
| Guéant, JL | 1 |
| Chandyo, RK | 2 |
| Ulak, M | 2 |
| Kvestad, I | 1 |
| Hysing, M | 1 |
| Shrestha, M | 1 |
| Ranjitkar, S | 1 |
| Ulvik, A | 1 |
| Ueland, PM | 9 |
| Shrestha, L | 1 |
| Strand, TA | 4 |
| DeLoughery, EP | 1 |
| Ravindran, A | 1 |
| Ashrani, AA | 1 |
| Begna, KH | 1 |
| Hook, CC | 1 |
| Marshall, AL | 1 |
| Pruthi, RK | 1 |
| Wolanskyj-Spinner, AP | 1 |
| Go, RS | 1 |
| Finer, S | 1 |
| Saravanan, P | 1 |
| Hitman, G | 1 |
| Yajnik, C | 1 |
| Sommerfelt, H | 3 |
| Schneede, J | 7 |
| Pascoe, MC | 1 |
| Linden, T | 1 |
| Beise, U | 1 |
| Burkart, A | 1 |
| Huber, F | 1 |
| Selhub, J | 1 |
| Jacques, PF | 1 |
| Dallal, G | 1 |
| Choumenkovitch, S | 1 |
| Rogers, G | 1 |
| Tangney, CC | 1 |
| Tang, Y | 1 |
| Evans, DA | 1 |
| Morris, MC | 1 |
| Hay, G | 1 |
| Trygg, K | 1 |
| Whitelaw, A | 1 |
| Johnston, C | 2 |
| Refsum, H | 6 |
| Lamarre, SG | 1 |
| Molloy, AM | 1 |
| Reinke, SN | 1 |
| Sykes, BD | 1 |
| Brosnan, ME | 1 |
| Brosnan, JT | 1 |
| Schoendorfer, NC | 1 |
| Obeid, R | 1 |
| Moxon-Lester, L | 1 |
| Sharp, N | 1 |
| Vitetta, L | 1 |
| Boyd, RN | 1 |
| Davies, PS | 1 |
| Taneja, S | 2 |
| Bahl, R | 2 |
| Bhandari, N | 2 |
| Hultberg, B | 3 |
| Nilsson, K | 3 |
| Isaksson, A | 2 |
| Gustafson, L | 3 |
| Clarke, R | 1 |
| Birks, J | 1 |
| Evans, JG | 1 |
| Sherliker, P | 1 |
| McPartlin, J | 1 |
| Nexo, E | 1 |
| Scott, JM | 1 |
| Segal, R | 1 |
| Baumoehl, Y | 1 |
| Elkayam, O | 1 |
| Levartovsky, D | 1 |
| Litinsky, I | 1 |
| Paran, D | 1 |
| Wigler, I | 1 |
| Habot, B | 1 |
| Leibovitz, A | 1 |
| Sela, BA | 1 |
| Caspi, D | 1 |
| Bjørke Monsen, AL | 2 |
| WHITE, AM | 1 |
| COX, EV | 1 |
| Lewerin, C | 3 |
| Nilsson-Ehle, H | 3 |
| Matousek, M | 2 |
| Lindstedt, G | 1 |
| Steen, B | 2 |
| Moretti, R | 1 |
| Torre, P | 1 |
| Antonello, RM | 1 |
| Cattaruzza, T | 1 |
| Cazzato, G | 1 |
| Bava, A | 1 |
| Steen, G | 1 |
| Johansson, B | 1 |
| Ramlau-Hansen, CH | 1 |
| Møller, UK | 1 |
| Henriksen, TB | 1 |
| Nexø, E | 1 |
| Møller, J | 1 |
| McCracken, C | 1 |
| Hudson, P | 1 |
| Ellis, R | 1 |
| McCaddon, A | 1 |
| Ljungman, S | 1 |
| Bhan, MK | 1 |
| Balfour, IC | 1 |
| Lane, DW | 1 |
| Matthews, DM | 1 |
| Linnell, JC | 1 |
| Tanaka, K | 1 |
| Aberhart, DJ | 1 |
| Amster, JI | 1 |
| Jenkins, EE | 1 |
| Hsu, CT | 1 |
| Savage, D | 1 |
| Gangaidzo, I | 1 |
| Lindenbaum, J | 5 |
| Kiire, C | 1 |
| Mukiibi, JM | 1 |
| Moyo, A | 1 |
| Gwanzura, C | 1 |
| Mudenge, B | 1 |
| Bennie, A | 1 |
| Sitima, J | 1 |
| Rosenberg, IH | 1 |
| Wilson, PW | 1 |
| Stabler, SP | 7 |
| Allen, RH | 6 |
| Savage, DG | 2 |
| Green, R | 1 |
| Guttormsen, AB | 1 |
| Rasmussen, K | 1 |
| Koehler, KM | 1 |
| Romero, LJ | 1 |
| Stauber, PM | 1 |
| Pareo-Tubbeh, SL | 1 |
| Liang, HC | 1 |
| Baumgartner, RN | 1 |
| Garry, PJ | 1 |
| Leeming, RJ | 1 |
| Joosten, E | 1 |
| Lesaffre, E | 1 |
| Riezler, R | 1 |
| Ghekiere, V | 1 |
| Dereymaeker, L | 1 |
| Pelemans, W | 1 |
| Dejaeger, E | 1 |
| Marín, GH | 1 |
| Tentoni, J | 1 |
| Cicchetti, G | 1 |
| Hultdin, J | 1 |
| Snow, CF | 1 |
| Bächli, E | 1 |
| Fehr, J | 1 |
| Fried, LP | 1 |
| Pahor, M | 1 |
| Kittner, SJ | 1 |
| Penninx, BW | 1 |
| Guralnik, JM | 1 |
| Ogundipe, A | 1 |
| Klee, GG | 1 |
| Herrmann, W | 1 |
| Schorr, H | 1 |
| Bodis, M | 1 |
| Knapp, JP | 1 |
| Müller, A | 1 |
| Stein, G | 1 |
| Geisel, J | 1 |
| McMullin, MF | 1 |
| Young, PB | 1 |
| Bailie, KE | 1 |
| Savage, GA | 1 |
| Lappin, TR | 1 |
| White, R | 1 |
| Bondevik, GT | 1 |
| Lie, RT | 1 |
| Ulstein, M | 1 |
| Kvåle, G | 1 |
| Nakamura, T | 1 |
| Saionji, K | 1 |
| Hiejima, Y | 1 |
| Hirayama, H | 1 |
| Tago, K | 1 |
| Takano, H | 1 |
| Tajiri, M | 1 |
| Hayashi, K | 1 |
| Kawabata, M | 1 |
| Funamizu, M | 1 |
| Makita, Y | 1 |
| Hata, A | 1 |
| Abd-el-Gawa, G | 1 |
| Abrahamsson, K | 1 |
| Norlén, L | 1 |
| Hjälmås, K | 1 |
| Hanson, E | 1 |
| Carmel, R | 1 |
| Rosenberg, LE | 1 |
| Frenkel, EP | 1 |
| Kitchens, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children[NCT00272116] | 2,482 participants (Actual) | Interventional | 1998-02-28 | Completed | |||
| Supplementation of Vitamin B12 in Pregnancy and Postpartum on Growth and Cognitive Functioning in Early Childhood: A Randomized, Placebo Controlled Trial[NCT03071666] | Phase 2/Phase 3 | 800 participants (Actual) | Interventional | 2017-03-27 | Active, not recruiting | ||
| Vitamin B12 Status in Infancy and the Effect of Providing Vitamin B12 to Infants With Signs of Suboptimal Vitamin B12 Status - a Registry-based, Randomized Controlled Trial[NCT05005897] | Phase 2/Phase 3 | 600 participants (Anticipated) | Interventional | 2021-12-08 | Recruiting | ||
| The Effect of Vitamin B12 Supplementation in Nepali Infants on Growth and Development[NCT02272842] | Phase 2/Phase 3 | 600 participants (Actual) | Interventional | 2015-04-20 | Active, not recruiting | ||
| Cross-sectional Study of the Association of Muscle Strength, Tinetti Test (POMA) Scores and Other Predictor Variables With Serum Vitamin Levels (Vitamin B12, Vitamin D and Folate) in Elderly Patients With Type 2 Diabetes Mellitus[NCT03376490] | 56 participants (Actual) | Observational | 2012-01-01 | Completed | |||
| Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections in Young Indian Children[NCT00717730] | Phase 2 | 1,000 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Wechsler Preschool and Primary Scale of Intelligence - Fourth Edition. This is a test of general abilities (IQ-test) Expected mean (SD): 100 (15), higher value indicate better cognitive functioning. Range approx. 40-140" (NCT02272842)
Timeframe: 3 years
| Intervention | IQ points (Mean) |
|---|---|
| Vitamin B12 | 84.4 |
| Placebo | 85.0 |
Change in hemoglobin concentration from baseline to end study. (NCT02272842)
Timeframe: 12 months
| Intervention | g/dl (Mean) |
|---|---|
| Vitamin B12 | 1.1 |
| Placebo | 1.0 |
Cognitive, Fine Motor, Gross Motor, Receptive language, and Expressive language scaled scores of the Bayley Scales of Infant Development version 3. This scale measures different aspects of neurodevelopment. The mean (SD) scores are usually 100 (15), and 95% of the population has scores between 70 and 130 (theoretical max/means 0/200). The higher scores, the better neurodevelopment; the scale is normalized on age. (NCT02272842)
Timeframe: 12 months
| Intervention | Scaled Scores (Mean) | ||||
|---|---|---|---|---|---|
| Cognitive | Receptive language | Expressive language | Fine Motor | Gross Motor | |
| Placebo | 8.2 | 8.9 | 8.5 | 10.9 | 9.1 |
| Vitamin B12 | 8.1 | 9.0 | 8.6 | 10.7 | 9.2 |
We will draw a blood sample at study start and at end study to measure to what extent vitamin status is altered. (NCT02272842)
Timeframe: 12 months
| Intervention | mol/L (Mean) | ||
|---|---|---|---|
| Cobalamin | homocysteine' | Methyl Malonic acid | |
| Placebo | 290.1 | 8.2 | .4 |
| Vitamin B12 | 316.3 | 6.6 | 0.3 |
15 reviews available for methylmalonic acid and Deficiency, Folic Acid
| Article | Year |
|---|---|
The role of the one-carbon cycle in the developmental origins of Type 2 diabetes and obesity.
Topics: Adiposity; Carbon Cycle; Diabetes Mellitus, Type 2; Environmental Exposure; Female; Fetal Developmen | 2014 |
Topics: Algorithms; Diagnosis, Differential; Folic Acid; Folic Acid Deficiency; Guideline Adherence; Humans; | 2016 |
The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status.
Topics: Biomarkers; Erythrocytes; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; Humans; | 2008 |
Homocysteine and methylmalonic acid in diagnosis and risk assessment from infancy to adolescence.
Topics: Adolescent; Child; Child, Preschool; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocystein | 2003 |
Vitamin B12 and folate depletion in cognition: a review.
Topics: Cognition; Cognition Disorders; Dementia; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; M | 2004 |
[Measurement of methylmalonic acid, homocysteine and methionine in cobalamin and folate deficiencies and homocysteinuria].
Topics: Amino Acid Metabolism, Inborn Errors; Biomarkers; Diagnosis, Differential; Folic Acid; Folic Acid De | 2008 |
Cobalamin deficiency and related disorders in infancy and childhood.
Topics: Child, Preschool; Diagnosis, Differential; Female; Folic Acid Deficiency; Homocystinuria; Humans; In | 1982 |
Metabolite assays in cobalamin and folate deficiency.
Topics: Folic Acid Deficiency; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1995 |
[P-methylmalonate and P-homocysteine: metabolic markers of vitamin deficiencies. Background, validity and applications].
Topics: Amino Acids; Biomarkers; Blood Chemical Analysis; Evaluation Studies as Topic; Folic Acid Deficiency | 1996 |
Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician.
Topics: Antibodies; Clinical Laboratory Techniques; Clinical Trials as Topic; Decision Trees; Diagnosis, Dif | 1999 |
[Diagnosis of vitamin B12 deficiency: only apparently child's play].
Topics: Aging; Anemia, Pernicious; Blood Cell Count; Diagnosis, Differential; Folic Acid Deficiency; Gastrit | 1999 |
Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate.
Topics: Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B | 2000 |
[Homocysteine and methylmalonic acid as markers of cobalamin/folate status. The association to neuropsychiatric symptoms in the elderly is explored].
Topics: Aged; Biomarkers; Cognition Disorders; Diagnosis, Differential; Folic Acid Deficiency; Geriatric Psy | 2000 |
The laboratory diagnosis of megaloblastic anemias.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Clinical Laboratory Techniques; Erythrocytes; | 1978 |
Vitamin-responsive inherited metabolic disorders.
Topics: Adolescent; Adult; Anemia, Megaloblastic; Avitaminosis; Biological Transport; Biotin; Carrier Protei | 1976 |
6 trials available for methylmalonic acid and Deficiency, Folic Acid
| Article | Year |
|---|---|
Cobalamin and Folate Status among Breastfed Infants in Bhaktapur, Nepal.
Topics: Biomarkers; Breast Feeding; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Homo | 2018 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Reduction of plasma homocysteine and serum methylmalonate concentrations in apparently healthy elderly subjects after treatment with folic acid, vitamin B12 and vitamin B6: a randomised trial.
Topics: Aged; Aged, 80 and over; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocystein | 2003 |
Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study.
Topics: Aged; Cognition; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Geriatrics; Homocys | 2005 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Huma | 2007 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Huma | 2007 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Huma | 2007 |
Cobalamin and folate status in infants and young children in a low-to-middle income community in India.
Topics: Child, Preschool; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Huma | 2007 |
The plasma homocysteine concentration is better than that of serum methylmalonic acid as a marker for sociopsychological performance in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Dementia; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; | 2000 |
40 other studies available for methylmalonic acid and Deficiency, Folic Acid
| Article | Year |
|---|---|
Normal serum cobalamin levels do not exclude the diagnosis of pernicious anaemia: a case report.
Topics: Anemia, Pernicious; Female; Folic Acid Deficiency; Gastritis, Atrophic; Homocysteine; Humans; Hydrox | 2020 |
Test utilization for the diagnosis of vitamin B12 and folate deficiency in local clinics in Korea.
Topics: Adult; Anemia, Macrocytic; Blood Chemical Analysis; Erythrocyte Indices; Folic Acid; Folic Acid Defi | 2020 |
Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients.
Topics: Adult; Cardiovascular Diseases; Child, Preschool; Cross-Sectional Studies; Female; Folic Acid; Folic | 2021 |
Patterns and utility of vitamin B12 and folate testing in patients with isolated thrombocytopenia.
Topics: Adult; Aged; Aged, 80 and over; Diagnostic Tests, Routine; Female; Folic Acid; Folic Acid Deficiency | 2019 |
Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Cross-Sectional Studies; Energy Intake; Female; Fol | 2016 |
Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Cross-Sectional Studies; Female; Folic Acid; Folic Aci | 2016 |
Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition Disorders; Cohort Studies; Female; Folic Acid; Folic | 2009 |
Folate and cobalamin status in relation to diet in healthy 2-y-old children.
Topics: Child, Preschool; Dairy Products; Diet; Diet Records; Dietary Supplements; Female; Folic Acid; Folic | 2011 |
Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration.
Topics: Animals; Biomarkers; Brain; Folic Acid Deficiency; Formates; Homocysteine; Hyperhomocysteinemia; Liv | 2012 |
Methylation capacity in children with severe cerebral palsy.
Topics: Betaine; Biomarkers; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Choline; Cystath | 2012 |
Folate deficiency is a common finding in psychogeriatric patients.
Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Female; Folic Acid; Folic Acid Deficiency; Homo | 2002 |
Screening for vitamin B-12 and folate deficiency in older persons.
Topics: Age Factors; Aged; Aged, 80 and over; Creatinine; Female; Folic Acid; Folic Acid Deficiency; Hemoglo | 2003 |
Anemia, serum vitamin B12, and folic acid in patients with rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus.
Topics: Adult; Aged; Aged, 80 and over; Anemia; Arthritis, Psoriatic; Arthritis, Rheumatoid; Cohort Studies; | 2004 |
METHYLMALONIC ACID EXCRETION AND VITAMIN B12 DEFICIENCY IN THE HUMAN.
Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Carcinoma; Celiac Disease; Chromatography; Crohn Dis | 1964 |
Folate and vitamin B12 in relation to lactation: a 9-month postpartum follow-up study.
Topics: Adult; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Lactati | 2006 |
Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study.
Topics: Aged; Aged, 80 and over; Aging; Cognition; Cohort Studies; Cross-Sectional Studies; Female; Folic Ac | 2006 |
Glomerular filtration rate as measured by serum cystatin C is an important determinant of plasma homocysteine and serum methylmalonic acid in the elderly.
Topics: Aged; Avitaminosis; Biomarkers; Creatinine; Cystatin C; Cystatins; Female; Folic Acid; Folic Acid De | 2007 |
Problems with vitamin B12 assays.
Topics: Folic Acid Deficiency; Humans; Malonates; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency | 1980 |
Metabolism of valine chirally labeled with carbon 13 and deuterium in vitamin B12-folate-deficient rats in vivo. Studies on the physiological role of keto-enol tautomerization.
Topics: Animals; Butyrates; Carbon Isotopes; Deuterium; Folic Acid Deficiency; Isobutyrates; Isomerism; Isot | 1980 |
Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe.
Topics: Anemia, Megaloblastic; Anemia, Pernicious; Erythrocyte Indices; Female; Folic Acid; Folic Acid Defic | 1994 |
Guidelines on the investigation and diagnosis of cobalamin and folate deficiencies. A publication of the British Committee for Standards in Haematology. BCSH General Haematology Test Force.
Topics: Blood Cell Count; Bone Marrow Examination; Deoxyuridine; Folic Acid Deficiency; Homocysteine; Humans | 1994 |
Prevalence of cobalamin deficiency in the Framingham elderly population.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cohort Studies; Female; Folic Acid Deficiency; Gas Chromatogr | 1994 |
Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies.
Topics: Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylmalonic Acid; Predictive Value of T | 1994 |
Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency.
Topics: Adolescent; Adult; Aged; Female; Folic Acid; Folic Acid Deficiency; Half-Life; Hematinics; Homocyste | 1996 |
The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency.
Topics: Adolescent; Adult; Aged; Female; Folic Acid Deficiency; Homocysteine; Humans; Male; Methylmalonic Ac | 1996 |
Vitamin supplementation and other variables affecting serum homocysteine and methylmalonic acid concentrations in elderly men and women.
Topics: Aged; Aged, 80 and over; Female; Folic Acid; Folic Acid Deficiency; Food, Fortified; Homocysteine; H | 1996 |
Cobalamin and folate deficiencies.
Topics: Biomarkers; Chemistry, Clinical; Folic Acid; Folic Acid Deficiency; Hematology; Homocysteine; Humans | 1996 |
Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease?
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Female; Folic Acid Deficiency; Homocysteine; Hosp | 1997 |
[Megaloblastic anemia: rapid and economical study].
Topics: Adolescent; Adult; Algorithms; Anemia, Megaloblastic; Cost Control; Diagnosis, Differential; Diagnos | 1997 |
[Functional deficiency of vitamin B12 and folate. No "parameter" is "meter"].
Topics: Biomarkers; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Specimen Handling; Vita | 1998 |
Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women.
Topics: Aged; Aged, 80 and over; Black People; Cross-Sectional Studies; Disabled Persons; Educational Status | 1999 |
Using homocysteine and related metabolites to diagnose vitamin deficiency states.
Topics: Aging; Animals; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Defici | 2000 |
Etiology and diagnostic evaluation of macrocytosis.
Topics: Adult; Aged; Alcohol Drinking; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow Diseases; Diag | 2000 |
Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects.
Topics: Adult; Aged; Cystathionine; Female; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; Kidney; | 2000 |
Homocysteine and methylmalonic acid as indicators of folate and vitamin B12 deficiency in pregnancy.
Topics: Adult; Biomarkers; Female; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Pregnanc | 2001 |
Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered?
Topics: Adolescent; Adult; Biomarkers; Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Fol | 2001 |
Total homocysteine is making its way into pediatric laboratory diagnostics.
Topics: Adult; Avitaminosis; Child; Diagnosis, Differential; Female; Folic Acid; Folic Acid Deficiency; HIV | 2001 |
Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients.
Topics: Cross-Sectional Studies; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Genotype; H | 2002 |
Vitamin B12 and folate after 5-12 years of continent ileal urostomy (Kock reservoir) in children and adolescents.
Topics: Adolescent; Child; Child Welfare; Colonic Pouches; Female; Folic Acid; Folic Acid Deficiency; Follow | 2002 |
Applicability of an enzymatic quantitation of methylmalonic, propionic, and acetic acids in normal and megaloblastic states.
Topics: Acetates; Anemia, Megaloblastic; Animals; Clinical Enzyme Tests; Folic Acid Deficiency; Humans; Malo | 1977 |