methylmalonic acid has been researched along with Cognitive Dysfunction in 9 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Cognitive Dysfunction: Diminished or impaired mental and/or intellectual function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diagnosis of vitamin B12 deficiency is difficult, as there is no conclusive single test for this disorder." | 1.56 | Association of vitamin B12, methylmalonic acid, and functional parameters. ( de Jong, WHA; Huls, G; van der Klauw, MM; Wolffenbuttel, BHR; Wouters, HJCM, 2020) |
| "Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance." | 1.39 | Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. ( Bjelland, I; Drevon, CA; Engedal, K; Nurk, E; Nygaard, HA; Refsum, H; Smith, DA; Tell, GS; Ueland, PM; Vollset, SE, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Li, A | 1 |
| Du, M | 1 |
| Chen, Y | 1 |
| Marks, LAM | 1 |
| Visser, A | 1 |
| Xu, S | 1 |
| Tjakkes, GE | 1 |
| Hooshmand, B | 1 |
| Appold, F | 1 |
| Fissler, P | 1 |
| Perneczky, R | 1 |
| Otto, M | 1 |
| Tumani, H | 1 |
| Kivipelto, M | 1 |
| von Arnim, CAF | 1 |
| Wolffenbuttel, BHR | 1 |
| Wouters, HJCM | 1 |
| de Jong, WHA | 1 |
| Huls, G | 1 |
| van der Klauw, MM | 1 |
| Shavlovskaya, OA | 1 |
| Bokova, IA | 1 |
| Shavlovskiy, NI | 1 |
| Yukhnovskaya, YD | 1 |
| Kvestad, I | 1 |
| Hysing, M | 1 |
| Shrestha, M | 1 |
| Ulak, M | 1 |
| Thorne-Lyman, AL | 1 |
| Henjum, S | 1 |
| Ueland, PM | 2 |
| Midttun, Ø | 1 |
| Fawzi, W | 1 |
| Chandyo, RK | 1 |
| Shrestha, PS | 1 |
| Strand, TA | 1 |
| Richterman, A | 1 |
| Vaidya, A | 1 |
| Brown, JM | 1 |
| Braun, DA | 1 |
| Samuels, MA | 1 |
| Kwok, T | 1 |
| Lee, J | 1 |
| Ma, RC | 1 |
| Wong, SY | 1 |
| Kung, K | 1 |
| Lam, A | 1 |
| Ho, CS | 1 |
| Lee, V | 1 |
| Harrison, J | 1 |
| Lam, L | 1 |
| Nurk, E | 1 |
| Refsum, H | 1 |
| Bjelland, I | 1 |
| Drevon, CA | 1 |
| Tell, GS | 1 |
| Vollset, SE | 1 |
| Engedal, K | 1 |
| Nygaard, HA | 1 |
| Smith, DA | 1 |
| O'Leary, F | 1 |
| Allman-Farinelli, M | 1 |
| Samman, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT02457507] | Phase 4 | 271 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for methylmalonic acid and Cognitive Dysfunction
| Article | Year |
|---|---|
Vitamin B₁₂ status, cognitive decline and dementia: a systematic review of prospective cohort studies.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition; Cognition Disorders; Cognitive Dysfunction; Dementia | 2012 |
1 trial available for methylmalonic acid and Cognitive Dysfunction
| Article | Year |
|---|---|
A randomized placebo controlled trial of vitamin B
Topics: Aged; Cholesterol; Cognitive Dysfunction; Creatinine; Diabetes Mellitus; Dietary Supplements; Female | 2017 |
7 other studies available for methylmalonic acid and Cognitive Dysfunction
| Article | Year |
|---|---|
Periodontitis and cognitive impairment in older adults: The mediating role of mitochondrial dysfunction.
Topics: Cognition; Cognitive Dysfunction; Cross-Sectional Studies; Humans; Methylmalonic Acid; Mitochondria; | 2022 |
Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition; Cognitive Dysfunction; Humans; Meth | 2023 |
Association of vitamin B12, methylmalonic acid, and functional parameters.
Topics: Adult; Aged; Cognition; Cognitive Dysfunction; Female; Hand Strength; Humans; Male; Methylmalonic Ac | 2020 |
[Cobalamin in the complex treatment and prevention of cognitive impairment].
Topics: Aged; Biomarkers; Cognitive Dysfunction; Female; Folic Acid; Humans; Methylmalonic Acid; Vitamin B 1 | 2021 |
Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children.
Topics: Adult; Asia; Child Development; Cognition; Cognitive Dysfunction; Female; Homocysteine; Humans; Infa | 2017 |
In the Balance.
Topics: Aged; Anemia, Pernicious; Brain; Cognitive Dysfunction; Diagnosis, Differential; Humans; Injections, | 2018 |
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Cognitive Dysfunction; Cohort Studies | 2013 |