methylmalonic acid has been researched along with Cognition Disorders in 30 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We attempted to attribute associations that we previously found between higher folate status and anemia and cognitive test performance to circulating unmetabolized folic acid or 5-methyltetrahydrofolate (5MeTHF)." | 7.76 | Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2010) |
| "We attempted to attribute associations that we previously found between higher folate status and anemia and cognitive test performance to circulating unmetabolized folic acid or 5-methyltetrahydrofolate (5MeTHF)." | 3.76 | Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2010) |
| " The authors summarized dose-response evidence from randomized controlled trials and prospective cohort studies on the relation of vitamin B12 intake and status with cognitive function in adults and elderly people." | 2.49 | Vitamin B12 intake and status and cognitive function in elderly people. ( Brzozowska, A; Cavelaars, AE; de Groot, LC; Dhonukshe-Rutten, RA; Doets, EL; Dullemeijer, C; Souverein, OW; Szczecińska, A; van 't Veer, P; van Wijngaarden, JP, 2013) |
| "Methylmalonic acidemia is an inborn error of metabolism known to be a cause of ketoacidosis and mental retardation." | 2.41 | High cognitive outcome in an adolescent with mut- methylmalonic acidemia. ( Levy, HL; Repetto, GM; Varvogli, L; Waisbren, SE, 2000) |
| "The patient had progressive, severe leukoencephalopathy on multiple MRI scans over 5 years." | 1.36 | Vitamin B12-responsive severe leukoencephalopathy and autonomic dysfunction in a patient with "normal" serum B12 levels. ( Graber, JJ; Kaufmann, H; Kolodny, EH; Sathe, S; Sherman, FT, 2010) |
| "Previous reports on pernicious anemia treatment suggested that high folic acid intake adversely influences the natural history of vitamin B-12 deficiency, which affects many elderly individuals." | 1.35 | Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2009) |
| "To examine the effect of vitamin B12 deficiency on older veterans and its relationship to general health and cognitive impairment." | 1.30 | The effect of vitamin B12 deficiency on older veterans and its relationship to health. ( Bernard, MA; Kashner, TM; Nakonezny, PA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 14 (46.67) | 29.6817 |
| 2010's | 13 (43.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solomon, LR | 1 |
| Doets, EL | 2 |
| Ueland, PM | 5 |
| Tell, GS | 2 |
| Vollset, SE | 2 |
| Nygård, OK | 1 |
| Van't Veer, P | 1 |
| de Groot, LC | 3 |
| Nurk, E | 2 |
| Refsum, H | 4 |
| Smith, AD | 3 |
| Eussen, SJ | 2 |
| Pascoe, MC | 1 |
| Linden, T | 1 |
| Selhub, J | 3 |
| Morris, MS | 2 |
| Jacques, PF | 3 |
| Rosenberg, IH | 2 |
| Tangney, CC | 1 |
| Tang, Y | 1 |
| Evans, DA | 1 |
| Morris, MC | 1 |
| Graber, JJ | 1 |
| Sherman, FT | 1 |
| Kaufmann, H | 1 |
| Kolodny, EH | 1 |
| Sathe, S | 1 |
| Chatthanawaree, W | 1 |
| Yetley, EA | 2 |
| Pfeiffer, CM | 2 |
| Phinney, KW | 1 |
| Bailey, RL | 2 |
| Blackmore, S | 1 |
| Bock, JL | 1 |
| Brody, LC | 1 |
| Carmel, R | 2 |
| Curtin, LR | 1 |
| Durazo-Arvizu, RA | 1 |
| Eckfeldt, JH | 1 |
| Green, R | 2 |
| Gregory, JF | 1 |
| Hoofnagle, AN | 1 |
| Jacobsen, DW | 1 |
| Lacher, DA | 1 |
| Molloy, AM | 1 |
| Massaro, J | 1 |
| Mills, JL | 1 |
| Nexo, E | 3 |
| Rader, JI | 1 |
| Sempos, C | 1 |
| Shane, B | 1 |
| Stabler, S | 1 |
| Stover, P | 1 |
| Tamura, T | 1 |
| Tedstone, A | 1 |
| Thorpe, SJ | 1 |
| Coates, PM | 1 |
| Johnson, CL | 1 |
| Picciano, MF | 1 |
| Cogswell, ME | 1 |
| Osterloh, JD | 1 |
| Sempos, CT | 1 |
| Lildballe, DL | 1 |
| Fedosov, S | 1 |
| Sherliker, P | 1 |
| Hin, H | 1 |
| Clarke, R | 3 |
| O'Leary, F | 1 |
| Allman-Farinelli, M | 1 |
| Samman, S | 1 |
| Vogiatzoglou, A | 1 |
| Drevon, CA | 1 |
| Nygaard, HA | 1 |
| Engedal, K | 1 |
| van Wijngaarden, JP | 1 |
| Szczecińska, A | 1 |
| Dullemeijer, C | 1 |
| Souverein, OW | 1 |
| Dhonukshe-Rutten, RA | 1 |
| Cavelaars, AE | 1 |
| van 't Veer, P | 1 |
| Brzozowska, A | 1 |
| Strand, TA | 1 |
| Taneja, S | 1 |
| Bahl, R | 1 |
| Schneede, J | 3 |
| Sommerfelt, H | 1 |
| Bhandari, N | 1 |
| Nilsson, K | 3 |
| Gustafson, L | 3 |
| Hultberg, B | 3 |
| Isaksson, A | 2 |
| Pettenuzzo, LF | 1 |
| Wyse, AT | 1 |
| Wannmacher, CM | 1 |
| Dutra-Filho, CS | 1 |
| Netto, CA | 1 |
| Wajner, M | 1 |
| Moretti, R | 1 |
| Torre, P | 1 |
| Antonello, RM | 1 |
| Cattaruzza, T | 1 |
| Cazzato, G | 1 |
| Bava, A | 1 |
| Boxer, AL | 1 |
| Kramer, JH | 1 |
| Johnston, K | 1 |
| Goldman, J | 1 |
| Finley, R | 1 |
| Miller, BL | 1 |
| Lewis, MS | 1 |
| Miller, LS | 1 |
| Johnson, MA | 1 |
| Dolce, EB | 1 |
| Allen, RH | 1 |
| Stabler, SP | 2 |
| Joosten, LW | 1 |
| Bloo, RJ | 1 |
| Blom, HJ | 1 |
| Hoefnagels, WH | 1 |
| van Staveren, WA | 1 |
| Morioka, D | 1 |
| Kasahara, M | 1 |
| Horikawa, R | 1 |
| Yokoyama, S | 1 |
| Fukuda, A | 1 |
| Nakagawa, A | 1 |
| Birks, J | 1 |
| Scott, J | 1 |
| Molloy, A | 1 |
| Evans, JG | 1 |
| Nicolaides, P | 1 |
| Leonard, J | 1 |
| Surtees, R | 1 |
| Bernard, MA | 1 |
| Nakonezny, PA | 1 |
| Kashner, TM | 1 |
| Varvogli, L | 1 |
| Repetto, GM | 1 |
| Waisbren, SE | 1 |
| Levy, HL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Zinc and Vitamin A Supplementation on Diarrhea, Physical Growth and Immune Response in Malnourished Children[NCT00272116] | 2,482 participants (Actual) | Interventional | 1998-02-28 | Completed | |||
| Supplementation of Vitamin B12 in Pregnancy and Postpartum on Growth and Cognitive Functioning in Early Childhood: A Randomized, Placebo Controlled Trial[NCT03071666] | Phase 2/Phase 3 | 800 participants (Actual) | Interventional | 2017-03-27 | Active, not recruiting | ||
| Vitamin B12 Status in Infancy and the Effect of Providing Vitamin B12 to Infants With Signs of Suboptimal Vitamin B12 Status - a Registry-based, Randomized Controlled Trial[NCT05005897] | Phase 2/Phase 3 | 600 participants (Anticipated) | Interventional | 2021-12-08 | Recruiting | ||
| The Effect of Vitamin B12 Supplementation in Nepali Infants on Growth and Development[NCT02272842] | Phase 2/Phase 3 | 600 participants (Actual) | Interventional | 2015-04-20 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Wechsler Preschool and Primary Scale of Intelligence - Fourth Edition. This is a test of general abilities (IQ-test) Expected mean (SD): 100 (15), higher value indicate better cognitive functioning. Range approx. 40-140" (NCT02272842)
Timeframe: 3 years
| Intervention | IQ points (Mean) |
|---|---|
| Vitamin B12 | 84.4 |
| Placebo | 85.0 |
Change in hemoglobin concentration from baseline to end study. (NCT02272842)
Timeframe: 12 months
| Intervention | g/dl (Mean) |
|---|---|
| Vitamin B12 | 1.1 |
| Placebo | 1.0 |
Cognitive, Fine Motor, Gross Motor, Receptive language, and Expressive language scaled scores of the Bayley Scales of Infant Development version 3. This scale measures different aspects of neurodevelopment. The mean (SD) scores are usually 100 (15), and 95% of the population has scores between 70 and 130 (theoretical max/means 0/200). The higher scores, the better neurodevelopment; the scale is normalized on age. (NCT02272842)
Timeframe: 12 months
| Intervention | Scaled Scores (Mean) | ||||
|---|---|---|---|---|---|
| Cognitive | Receptive language | Expressive language | Fine Motor | Gross Motor | |
| Placebo | 8.2 | 8.9 | 8.5 | 10.9 | 9.1 |
| Vitamin B12 | 8.1 | 9.0 | 8.6 | 10.7 | 9.2 |
We will draw a blood sample at study start and at end study to measure to what extent vitamin status is altered. (NCT02272842)
Timeframe: 12 months
| Intervention | mol/L (Mean) | ||
|---|---|---|---|
| Cobalamin | homocysteine' | Methyl Malonic acid | |
| Placebo | 290.1 | 8.2 | .4 |
| Vitamin B12 | 316.3 | 6.6 | 0.3 |
9 reviews available for methylmalonic acid and Cognition Disorders
| Article | Year |
|---|---|
Vitamin B-12 and cognition in the elderly.
Topics: Aged; Aging; Biomarkers; Cognition Disorders; Female; Humans; Male; Methylmalonic Acid; Nutritional | 2009 |
Biomarkers of cobalamin (vitamin B12) deficiency and its application.
Topics: Aging; Biomarkers; Cognition Disorders; Erythrocyte Indices; Female; Homocysteine; Humans; Male; Met | 2011 |
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary.
Topics: Biomarkers; Cognition Disorders; Homocysteine; Humans; Methylmalonic Acid; Nutrition Surveys; Public | 2011 |
Vitamin B₁₂ status, cognitive decline and dementia: a systematic review of prospective cohort studies.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition; Cognition Disorders; Cognitive Dysfunction; Dementia | 2012 |
Vitamin B12 intake and status and cognitive function in elderly people.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cognition Disorders; Dementia; Diet; Humans; | 2013 |
Vitamin B12 and folate depletion in cognition: a review.
Topics: Cognition; Cognition Disorders; Dementia; Folic Acid; Folic Acid Deficiency; Homocysteine; Humans; M | 2004 |
Vitamin B12 deficiency in older people: improving diagnosis and preventing disability.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Humans; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 | 1998 |
High cognitive outcome in an adolescent with mut- methylmalonic acidemia.
Topics: Adolescent; Child; Cognition Disorders; Female; Humans; Intelligence Tests; Lipid Metabolism, Inborn | 2000 |
[Homocysteine and methylmalonic acid as markers of cobalamin/folate status. The association to neuropsychiatric symptoms in the elderly is explored].
Topics: Aged; Biomarkers; Cognition Disorders; Diagnosis, Differential; Folic Acid Deficiency; Geriatric Psy | 2000 |
2 trials available for methylmalonic acid and Cognition Disorders
| Article | Year |
|---|---|
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age.
Topics: Biomarkers; Child Development; Cognition Disorders; Cohort Studies; Developmental Disabilities; Fema | 2013 |
Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial.
Topics: Administration, Oral; Aged; Aged, 80 and over; Cognition; Cognition Disorders; Dietary Supplements; | 2006 |
19 other studies available for methylmalonic acid and Cognition Disorders
| Article | Year |
|---|---|
Advanced age as a risk factor for folate-associated functional cobalamin deficiency.
Topics: Aged; Aged, 80 and over; Causality; Cognition Disorders; Comorbidity; Female; Folic Acid; Geriatric | 2013 |
Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study.
Topics: Aged; Biomarkers; Cognition Disorders; Cross-Sectional Studies; Diet; Female; Folic Acid; Food, Fort | 2014 |
Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Cross-Sectional Studies; Female; Folic Acid; Folic Aci | 2016 |
Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aging; Anemia, Pernicious; Cognition Diso | 2009 |
Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline.
Topics: Aged; Aged, 80 and over; Biomarkers; Cognition Disorders; Cohort Studies; Female; Folic Acid; Folic | 2009 |
Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors.
Topics: Aged; Aging; Anemia; Anemia, Macrocytic; Blood Cell Count; Cognition; Cognition Disorders; Cystatin | 2010 |
Vitamin B12-responsive severe leukoencephalopathy and autonomic dysfunction in a patient with "normal" serum B12 levels.
Topics: Autoantibodies; Autonomic Nervous System Diseases; Brain; Cognition Disorders; Depressive Disorder; | 2010 |
Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12.
Topics: Adult; Biomarkers; Cognition Disorders; Cross-Sectional Studies; Female; Humans; Male; Methylmalonic | 2011 |
Association of cognitive impairment with combinations of vitamin B₁₂-related parameters.
Topics: Aged; Biomarkers; Case-Control Studies; Cognition Disorders; Cross-Sectional Studies; Homocysteine; | 2011 |
Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine Study.
Topics: Aged; Apolipoprotein E4; Cognition; Cognition Disorders; Cross-Sectional Studies; Depression; Female | 2013 |
Optimal use of markers for cobalamin and folate status in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition Disorders; Female; Folic Acid; Hom | 2002 |
Folate deficiency is a common finding in psychogeriatric patients.
Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Female; Folic Acid; Folic Acid Deficiency; Homo | 2002 |
Evaluation of the effect of chronic administration of drugs on rat behavior in the water maze task.
Topics: Animals; Behavior, Animal; Brain; Brain Diseases, Metabolic; Cognition Disorders; Disease Models, An | 2003 |
Executive dysfunction in hyperhomocystinemia responds to homocysteine-lowering treatment.
Topics: Adult; Anticoagulants; Betaine; Cognition Disorders; Confusion; Disease Progression; Drug Therapy, C | 2005 |
Elevated methylmalonic acid is related to cognitive impairement in older adults enrolled in an elderly nutrition program.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Dietary Services; Epidemiologic Methods; Female; Food | 2005 |
Efficacy of living donor liver transplantation for patients with methylmalonic acidemia.
Topics: Child; Child, Preschool; Cognition Disorders; Female; Follow-Up Studies; Growth Disorders; Humans; I | 2007 |
Low vitamin B-12 status and risk of cognitive decline in older adults.
Topics: Aged; Aged, 80 and over; Cognition Disorders; Cohort Studies; Female; Homocysteine; Humans; Longitud | 2007 |
Neurological outcome of methylmalonic acidaemia.
Topics: Adolescent; Adult; Age of Onset; Child; Child, Preschool; Cognition Disorders; Dystonia; Female; Hum | 1998 |
The effect of vitamin B12 deficiency on older veterans and its relationship to health.
Topics: Aged; Aged, 80 and over; Alcohol Drinking; Analysis of Variance; Cognition Disorders; Cross-Sectiona | 1998 |