methylmalonic acid has been researched along with Cardiovascular Diseases in 7 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The association of moderate hyperhomocysteinemia (HHcy) (15-30 μmol/L) with cardiovascular diseases (CVD) has been challenged by the lack of benefit of vitamin supplementation to lowering homocysteine." | 8.02 | Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients. ( Guéant, JL; Jeannesson, E; Levy, J; Oussalah, A; Rodriguez-Guéant, RM; Wahl, D; Ziuly, S, 2021) |
| " Forty-seven percent of the subjects had cobalamin deficiency (total cobalamin <150 pmol/L), 73% had low holoTC (<35 pmol/L), 77% had hyperhomocysteinemia (tHcy >15 micromol/L), and 73% had elevated serum MMA (>0." | 7.71 | Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. ( Gadkari, M; Guttormsen, AB; Joglekar, A; Orning, L; Refsum, H; Sayyad, MG; Schneede, J; Ueland, PM; Ulvik, A; Vollset, SE; Yajnik, CS, 2001) |
| "The association of moderate hyperhomocysteinemia (HHcy) (15-30 μmol/L) with cardiovascular diseases (CVD) has been challenged by the lack of benefit of vitamin supplementation to lowering homocysteine." | 4.02 | Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients. ( Guéant, JL; Jeannesson, E; Levy, J; Oussalah, A; Rodriguez-Guéant, RM; Wahl, D; Ziuly, S, 2021) |
| " Forty-seven percent of the subjects had cobalamin deficiency (total cobalamin <150 pmol/L), 73% had low holoTC (<35 pmol/L), 77% had hyperhomocysteinemia (tHcy >15 micromol/L), and 73% had elevated serum MMA (>0." | 3.71 | Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. ( Gadkari, M; Guttormsen, AB; Joglekar, A; Orning, L; Refsum, H; Sayyad, MG; Schneede, J; Ueland, PM; Ulvik, A; Vollset, SE; Yajnik, CS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, J | 1 |
| Liu, X | 1 |
| Wang, Z | 1 |
| Lu, R | 1 |
| Liu, Y | 2 |
| Zhang, Y | 1 |
| Tian, W | 2 |
| Fang, S | 2 |
| Wang, S | 2 |
| Yu, B | 2 |
| Lederer, AK | 1 |
| Hannibal, L | 1 |
| Hettich, M | 1 |
| Behringer, S | 1 |
| Spiekerkoetter, U | 1 |
| Steinborn, C | 1 |
| Gründemann, C | 1 |
| Zimmermann-Klemd, AM | 1 |
| Müller, A | 1 |
| Simmet, T | 1 |
| Schmiech, M | 1 |
| Maul-Pavicic, A | 1 |
| Samstag, Y | 1 |
| Huber, R | 1 |
| Liu, J | 1 |
| Zhang, X | 1 |
| Cai, H | 1 |
| Levy, J | 1 |
| Rodriguez-Guéant, RM | 1 |
| Oussalah, A | 1 |
| Jeannesson, E | 1 |
| Wahl, D | 1 |
| Ziuly, S | 1 |
| Guéant, JL | 1 |
| Wolters, M | 1 |
| Hermann, S | 1 |
| Hahn, A | 1 |
| Refsum, H | 1 |
| Yajnik, CS | 1 |
| Gadkari, M | 1 |
| Schneede, J | 1 |
| Vollset, SE | 1 |
| Orning, L | 1 |
| Guttormsen, AB | 1 |
| Joglekar, A | 1 |
| Sayyad, MG | 1 |
| Ulvik, A | 1 |
| Ueland, PM | 1 |
| Rydlewicz, A | 1 |
| Simpson, JA | 1 |
| Taylor, RJ | 1 |
| Bond, CM | 1 |
| Golden, MH | 1 |
3 trials available for methylmalonic acid and Cardiovascular Diseases
| Article | Year |
|---|---|
Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Cholesterol; Diet, Vegan; Fatty Acids; Female; Healthy V | 2019 |
Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; | 2005 |
The effect of folic acid supplementation on plasma homocysteine in an elderly population.
Topics: Aged; Cardiovascular Diseases; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic | 2002 |
4 other studies available for methylmalonic acid and Cardiovascular Diseases
| Article | Year |
|---|---|
Methylmalonic acid, vitamin B12, and mortality risk in patients with preexisting coronary heart disease: a prospective cohort study.
Topics: Adult; Aged; Cardiovascular Diseases; Humans; Male; Methylmalonic Acid; Nutrition Surveys; Prospecti | 2023 |
Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Child; Humans; Methylmalonic Acid; Mitochondria; Nutriti | 2020 |
Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients.
Topics: Adult; Cardiovascular Diseases; Child, Preschool; Cross-Sectional Studies; Female; Folic Acid; Folic | 2021 |
Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians.
Topics: Adult; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Diet, Vegetarian; Female; Folic Acid; | 2001 |