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methylmalonic acid and Canine Diseases

methylmalonic acid has been researched along with Canine Diseases in 12 studies

Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.

Research Excerpts

ExcerptRelevanceReference
"To evaluate efficacy of oral or injectable supplementation with cobalamin in normalizing serum cobalamin and methylmalonic acid (MMA) concentrations in dogs with hypocobalaminemia caused by either chronic enteropathy (CE) or exocrine pancreatic insufficiency (EPI)."5.51Effect of oral or injectable supplementation with cobalamin in dogs with hypocobalaminemia caused by chronic enteropathy or exocrine pancreatic insufficiency. ( Chang, CH; Lidbury, JA; Steiner, JM; Suchodolski, JS, 2022)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (25.00)18.2507
2000's0 (0.00)29.6817
2010's8 (66.67)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Chang, CH1
Lidbury, JA2
Suchodolski, JS6
Steiner, JM6
Kook, PH3
Reusch, CE2
Hersberger, M2
Toresson, L1
Spodsberg, E1
Olmedal, G1
Spillmann, T1
Grützner, N2
Heilmann, RM1
Stupka, KC1
Rangachari, VR1
Weber, K1
Holzenburg, A1
Berghoff, N2
Lutz, S1
Sewell, AC1
Bigler, B1
Riond, B1
Parnell, NK1
Hill, SL1
Podell, M1
Shelton, GD2
Nyhan, WL1
Wagner, SO1
Genders, A1
Oglesbee, M1
Fenner, WR1
O'Brien, DP1
Barshop, BA1
Faunt, KK1
Johnson, GC1
Gibson, KM1
Fyfe, JC1
Giger, U1
Hall, CA1
Jezyk, PF1
Klumpp, SA1
Levine, JS1
Patterson, DF1

Trials

2 trials available for methylmalonic acid and Canine Diseases

ArticleYear
Effect of oral or injectable supplementation with cobalamin in dogs with hypocobalaminemia caused by chronic enteropathy or exocrine pancreatic insufficiency.
    Journal of veterinary internal medicine, 2022, Volume: 36, Issue:5

    Topics: Animals; Dietary Supplements; Dog Diseases; Dogs; Exocrine Pancreatic Insufficiency; Inflammatory Bo

2022
Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations.
    Veterinary journal (London, England : 1997), 2019, Volume: 243

    Topics: Administration, Oral; Animals; Dietary Supplements; Dog Diseases; Dogs; Female; Homocysteine; Infusi

2019

Other Studies

10 other studies available for methylmalonic acid and Canine Diseases

ArticleYear
Prospective long-term evaluation of parenteral hydroxocobalamin supplementation in juvenile beagles with selective intestinal cobalamin malabsorption (Imerslund-Gräsbeck syndrome).
    Journal of veterinary internal medicine, 2018, Volume: 32, Issue:3

    Topics: Anemia, Megaloblastic; Animals; Creatinine; Dog Diseases; Dogs; Drug Administration Schedule; Female

2018
Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund-Gräsbeck syndrome) maintains normal clinical and cellular cobalamin status.
    Journal of veterinary internal medicine, 2019, Volume: 33, Issue:2

    Topics: Administration, Oral; Anemia, Megaloblastic; Animals; Dog Diseases; Dogs; Female; Malabsorption Synd

2019
Serum homocysteine and methylmalonic acid concentrations in Chinese Shar-Pei dogs with cobalamin deficiency.
    Veterinary journal (London, England : 1997), 2013, Volume: 197, Issue:2

    Topics: Animals; Dog Diseases; Dogs; Genetic Predisposition to Disease; Homocysteine; Methylmalonic Acid; Re

2013
Relationship between cobalamin-dependent metabolites and both serum albumin and alpha1 -proteinase inhibitor concentrations in hypocobalaminemic dogs of 7 different breeds.
    Veterinary clinical pathology, 2014, Volume: 43, Issue:4

    Topics: alpha-Macroglobulins; Animals; Biomarkers; Breeding; Dog Diseases; Dogs; Female; Homocysteine; Male;

2014
Association between serum cobalamin and methylmalonic acid concentrations in dogs.
    Veterinary journal (London, England : 1997), 2012, Volume: 191, Issue:3

    Topics: Animals; Biomarkers; Dog Diseases; Dogs; Methylmalonic Acid; Vitamin B 12; Vitamin B 12 Deficiency

2012
Serum cobalamin, urine methylmalonic acid, and plasma total homocysteine concentrations in Border Collies and dogs of other breeds.
    American journal of veterinary research, 2012, Volume: 73, Issue:8

    Topics: Amino Acid Metabolism, Inborn Errors; Animals; Biomarkers; Chromatography, Gas; Chromatography, High

2012
Serum cobalamin and methylmalonic acid concentrations in dogs with chronic gastrointestinal disease.
    American journal of veterinary research, 2013, Volume: 74, Issue:1

    Topics: Amino Acid Metabolism, Inborn Errors; Animals; Chronic Disease; Dog Diseases; Dogs; Female; Gas Chro

2013
Methylmalonic and malonic aciduria in a dog with progressive encephalomyelopathy.
    Metabolic brain disease, 1996, Volume: 11, Issue:3

    Topics: Animals; Brain; Dog Diseases; Dogs; Electromyography; Encephalomyelitis; Female; Gas Chromatography-

1996
Malonic aciduria in Maltese dogs: normal methylmalonic acid concentrations and malonyl-CoA decarboxylase activity in fibroblasts.
    Journal of inherited metabolic disease, 1999, Volume: 22, Issue:8

    Topics: Animals; Carboxy-Lyases; Diet; Dog Diseases; Dogs; Epilepsy, Tonic-Clonic; Female; Fibroblasts; Malo

1999
Inherited selective intestinal cobalamin malabsorption and cobalamin deficiency in dogs.
    Pediatric research, 1991, Volume: 29, Issue:1

    Topics: Animals; Dog Diseases; Dogs; Female; Genes, Recessive; Ileum; Intrinsic Factor; Malabsorption Syndro

1991