methylmalonic acid has been researched along with Brain Injuries in 1 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methylmalonic aciduria (MMAuria) is an inborn error of metabolism leading to neurological deterioration." | 1.48 | New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria. ( Ballhausen, D; Baumgartner, M; Braissant, O; Cudré-Cung, HP; do Vale-Pereira, S; Forny, P; Gallart-Ayala, H; Gonzalez-Melo, M; Henry, H; Remacle, N; Teav, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Remacle, N | 1 |
| Forny, P | 1 |
| Cudré-Cung, HP | 1 |
| Gonzalez-Melo, M | 1 |
| do Vale-Pereira, S | 1 |
| Henry, H | 1 |
| Teav, T | 1 |
| Gallart-Ayala, H | 1 |
| Braissant, O | 1 |
| Baumgartner, M | 1 |
| Ballhausen, D | 1 |
1 other study available for methylmalonic acid and Brain Injuries
| Article | Year |
|---|---|
New in vitro model derived from brain-specific Mut-/- mice confirms cerebral ammonium accumulation in methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonium Compounds; Animals; Brain; Brain Injuries; Humans; Me | 2018 |