methylmalonic acid has been researched along with Brain Edema in 1 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Combined methylmalonic aciduria and homocystinuria (MMA-HC) is caused by impaired hepatic conversion of dietary cobalamin to methylcobalamin and adenosylcobalamin, resulting in decreased activity of methylmalonyl-CoA mutase and methionine synthase." | 7.71 | Early-onset combined methylmalonic aciduria and homocystinuria: neuroradiologic findings. ( Biancheri, R; Cerone, R; Fonda, C; Gatti, R; Rossi, A; Schiaffino, MC; Tortori-Donati, P; Zammarchi, E, 2001) |
| "Combined methylmalonic aciduria and homocystinuria (MMA-HC) is caused by impaired hepatic conversion of dietary cobalamin to methylcobalamin and adenosylcobalamin, resulting in decreased activity of methylmalonyl-CoA mutase and methionine synthase." | 3.71 | Early-onset combined methylmalonic aciduria and homocystinuria: neuroradiologic findings. ( Biancheri, R; Cerone, R; Fonda, C; Gatti, R; Rossi, A; Schiaffino, MC; Tortori-Donati, P; Zammarchi, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rossi, A | 1 |
| Cerone, R | 1 |
| Biancheri, R | 1 |
| Gatti, R | 1 |
| Schiaffino, MC | 1 |
| Fonda, C | 1 |
| Zammarchi, E | 1 |
| Tortori-Donati, P | 1 |
1 other study available for methylmalonic acid and Brain Edema
| Article | Year |
|---|---|
Early-onset combined methylmalonic aciduria and homocystinuria: neuroradiologic findings.
Topics: Brain; Brain Edema; Demyelinating Diseases; Female; Gliosis; Homocystinuria; Humans; Infant; Infant, | 2001 |