methylmalonic acid has been researched along with Body Weight in 29 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The biochemical and growth responses to dietary branched-chain amino acid (BCAA) intake were studied in two children; one with a disorder of branched-chain amino acid metabolism, maple syrup urine disease (MSUD) (McKusick 24860), and another with methylmalonic aciduria (MMA) (McKusick 25100)." | 7.68 | Evaluation of branched-chain amino acid intake in children with maple syrup urine disease and methylmalonic aciduria. ( Carter, RJ; Parsons, HG; Snyder, FF; Unrath, M, 1990) |
| " The body weight of the mice fed on a B12-deficient diet for 90 days was slightly lower than that of the control mice administrated CN-B12, and the urinary excretion of methylmalonic acid (MMA) was increased." | 3.72 | Breeding severely vitamin B12-deficient mice as model animals. ( Arai, K; Funada, U; Kawata, T; Kuwamori, M; Maekawa, A; Matsushita, M; Sanai, T; Tadokoro, T; Tanaka, N; Wada, M; Yamada, H; Yamamoto, Y, 2004) |
| "The biochemical and growth responses to dietary branched-chain amino acid (BCAA) intake were studied in two children; one with a disorder of branched-chain amino acid metabolism, maple syrup urine disease (MSUD) (McKusick 24860), and another with methylmalonic aciduria (MMA) (McKusick 25100)." | 3.68 | Evaluation of branched-chain amino acid intake in children with maple syrup urine disease and methylmalonic aciduria. ( Carter, RJ; Parsons, HG; Snyder, FF; Unrath, M, 1990) |
| "Methylmalonic acidaemia (MMA) is a rare autosomal recessive inborn error of metabolism that typically presents in infancy with recurrent episodes of metabolic acidosis, developmental delay and failure to thrive." | 1.33 | Management of methylmalonic acidaemia by combined liver-kidney transplantation. ( Enns, GM; Millan, MT; Nagarajan, S; Sarwal, MM; Winter, S, 2005) |
| "To clarify the bioavailability of vitamin B12 in lyophylized purple laver (nori; Porphyra yezoensis), total vitamin B12 and vitamin B12 analogue contents in the laver were determined, and the effects of feeding the laver to vitamin B12-deficient rats were investigated." | 1.31 | Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status. ( Abe, K; Ebara, S; Miyamoto, E; Nakano, Y; Sugiyama, S; Takenaka, S; Tamura, Y; Tsuyama, S; Watanabe, F, 2001) |
| " We have previously demonstrated that methylmalonic and propionic acids induce a significant reduction of ganglioside N-acetylneuraminic acid in the brain of rats subjected to chronic administration of these metabolites." | 1.31 | Ganglioside alterations in the central nervous system of rats chronically injected with methylmalonic and propionic acids. ( Brusque, AM; Pettenuzzo, LE; Raasch, JR; Rocha, HP; Trindade, VM; Wajne, M; Wannmacher, CM, 2002) |
| "Body weight gains were significantly reduced at 1200 mg/kg and in all feed-restricted animals." | 1.29 | Effect of folate supplementation on clinical chemistry and hematologic changes related to bidisomide administration in the rat. ( Masson, M; Palate, B; Roba, J; Vandenberghe, Y, 1995) |
| " Our results showed that the concentration of IF protein in cerebellum was not affected by the treatments, whereas chronic administration of all drugs significantly decreased NF-H subunit concentration in rat cerebral cortex." | 1.28 | Diminished concentration of the NF-H subunit of neurofilaments in cerebral cortex of rats chronically treated with proline, methylmalonate and phenylalanine plus alpha-methylphenylalanine. ( Camargo, MM; Pureur, RP; Rubin, MA; Valente, GB; Wannmacher, CM, 1992) |
| "Carnitine metabolism was studied in the vitamin B-12-deficient rat to define the relationship between alterations in acylcarnitine generation and the development of methylmalonic aciduria." | 1.27 | Carnitine metabolism in the vitamin B-12-deficient rat. ( Brass, EP; Stabler, SP, 1988) |
| " In addition a dose-response effect of alanine was observed." | 1.27 | Alanine decreases the protein requirements of infants with inborn errors of amino acid metabolism. ( Algert, S; Kelts, DG; Nyhan, WL; Prodanos, C; Wolff, JA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (37.93) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cora, MC | 1 |
| Gwinn, W | 1 |
| Wilson, R | 1 |
| King, D | 1 |
| Waidyanatha, S | 1 |
| Kissling, GE | 1 |
| Brar, SS | 1 |
| Olivera, D | 1 |
| Blystone, C | 1 |
| Travlos, G | 1 |
| Chandyo, RK | 1 |
| Ulak, M | 1 |
| Sommerfelt, H | 1 |
| Schneede, J | 1 |
| Ueland, PM | 1 |
| Strand, TA | 1 |
| Hussein, L | 1 |
| Abdel Aziz, S | 1 |
| Tapouzada, S | 1 |
| Boehles, H | 1 |
| Benight, NM | 1 |
| Stoll, B | 1 |
| Chacko, S | 1 |
| da Silva, VR | 1 |
| Marini, JC | 1 |
| Gregory, JF | 1 |
| Stabler, SP | 2 |
| Burrin, DG | 1 |
| Dhonukshe-Rutten, RA | 1 |
| Lips, M | 1 |
| de Jong, N | 1 |
| Chin A Paw, MJ | 1 |
| Hiddink, GJ | 1 |
| van Dusseldorp, M | 1 |
| De Groot, LC | 1 |
| van Staveren, WA | 1 |
| Kawata, T | 2 |
| Funada, U | 1 |
| Wada, M | 2 |
| Matsushita, M | 1 |
| Sanai, T | 1 |
| Yamada, H | 1 |
| Kuwamori, M | 1 |
| Arai, K | 1 |
| Yamamoto, Y | 1 |
| Tanaka, N | 2 |
| Tadokoro, T | 2 |
| Maekawa, A | 2 |
| Nagarajan, S | 1 |
| Enns, GM | 1 |
| Millan, MT | 1 |
| Winter, S | 1 |
| Sarwal, MM | 1 |
| Nakao, M | 1 |
| Kono, N | 1 |
| Adachi, S | 1 |
| Ebara, S | 2 |
| Adachi, T | 1 |
| Miura, T | 1 |
| Yamaji, R | 1 |
| Inui, H | 1 |
| Nakano, Y | 3 |
| Wang, R | 1 |
| Zhu, X | 1 |
| Guo, F | 1 |
| Zhang, W | 1 |
| Jia, Z | 1 |
| Yamada, K | 1 |
| Mori, K | 1 |
| Tamai, H | 1 |
| Tobimatsu, T | 1 |
| Toraya, T | 1 |
| Brink, JJ | 1 |
| Beck, RA | 1 |
| Miller, JS | 1 |
| Thenen, SW | 2 |
| Mello, CF | 1 |
| Somer, JE | 1 |
| Tavaroni, V | 1 |
| Graciolli, R | 1 |
| Wu, V | 1 |
| Torres, G | 1 |
| Aguiar, F | 1 |
| Wajner, M | 2 |
| Wannmacher, CM | 4 |
| Vandenberghe, Y | 1 |
| Masson, M | 1 |
| Palate, B | 1 |
| Roba, J | 1 |
| Takenaka, S | 1 |
| Sugiyama, S | 1 |
| Miyamoto, E | 1 |
| Abe, K | 1 |
| Tamura, Y | 2 |
| Watanabe, F | 2 |
| Tsuyama, S | 1 |
| Trindade, VM | 2 |
| Brusque, AM | 1 |
| Raasch, JR | 1 |
| Pettenuzzo, LE | 1 |
| Rocha, HP | 1 |
| Wajne, M | 1 |
| Rubin, MA | 1 |
| Valente, GB | 1 |
| Camargo, MM | 1 |
| Pureur, RP | 1 |
| Fisher, GE | 1 |
| Tachikake, N | 1 |
| Saido, H | 1 |
| Yamanaka, H | 1 |
| Parsons, HG | 1 |
| Carter, RJ | 1 |
| Unrath, M | 1 |
| Snyder, FF | 1 |
| Rice, DA | 2 |
| McLoughlin, M | 1 |
| Blanchflower, WJ | 2 |
| McMurray, CH | 1 |
| Goodall, EA | 1 |
| Cullen, RW | 2 |
| Oace, SM | 2 |
| O'Harte, FP | 1 |
| Kennedy, DG | 1 |
| Brass, EP | 1 |
| Brites, EC | 1 |
| Dutra, JC | 1 |
| Buchalter, MS | 1 |
| Pons, AH | 1 |
| Pires, RF | 1 |
| Wannmacher, LE | 1 |
| Rosa Júnior, A | 1 |
| Hämäläinen, MM | 1 |
| Wolff, JA | 1 |
| Kelts, DG | 1 |
| Algert, S | 1 |
| Prodanos, C | 1 |
| Nyhan, WL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Bioavailability of Vitamin B12 From Nori in Vegetarians: a Dose Response Study[NCT05614960] | 30 participants (Actual) | Interventional | 2022-11-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
29 other studies available for methylmalonic acid and Body Weight
| Article | Year |
|---|---|
A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice.
Topics: Anemia, Megaloblastic; Animals; Body Weight; Cimicifuga; Female; Folic Acid; Homocysteine; Kidney; L | 2017 |
Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Cross-Sectional Studies; Energy Intake; Female; Fol | 2016 |
Serum vitamin B(12) concentrations among mothers and newborns and follow-up study to assess implication on the growth velocity and the urinary methylmalonic acid excretion.
Topics: Adolescent; Adult; Birth Weight; Body Weight; Child Development; Female; Humans; Infant, Newborn; Li | 2009 |
B-vitamin deficiency is protective against DSS-induced colitis in mice.
Topics: Analysis of Variance; Animals; Body Weight; Colitis; Dextran Sulfate; Gene Expression; Glutathione; | 2011 |
Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men.
Topics: Absorptiometry, Photon; Aged; Aged, 80 and over; Body Composition; Body Height; Body Weight; Bone De | 2003 |
Breeding severely vitamin B12-deficient mice as model animals.
Topics: Animals; Body Weight; Diet; Disease Models, Animal; Liver; Male; Maternal Nutritional Physiological | 2004 |
Management of methylmalonic acidaemia by combined liver-kidney transplantation.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Body Mass Index; Body Weight; Child; Developmental | 2005 |
Abnormal increase in the expression level of proliferating cell nuclear antigen (PCNA) in the liver and hepatic injury in rats with dietary cobalamin deficiency.
Topics: Alanine Transaminase; Animals; Biomarkers; Body Weight; Carnitine; Cell Proliferation; Growth Disord | 2006 |
Influence of different dietary levels of zinc on performance, vitamin B12, and blood parameters in lambs.
Topics: Animal Feed; Animals; Blood Glucose; Body Weight; Cobalt; Diet; Dietary Supplements; Dose-Response R | 2006 |
Testicular injury to rats fed on soybean protein-based vitamin B12-deficient diet can be reduced by methionine supplementation.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Analysis of Variance; Animals; Body Weigh | 2007 |
Relationship of urinary methylmalonic acid to vitamin B-12 concentrations and hematologic changes in rats fed vitamin B-12-deficient diets.
Topics: Animals; Body Weight; Bone Marrow; Brain; Hematocrit; Hemoglobins; Liver; Male; Malonates; Methylmal | 1980 |
Effects of postnatal methylmalonate administration on neurobehavioral development of rats.
Topics: Animals; Behavior, Animal; Body Weight; Female; Growth; Male; Methylmalonic Acid; Motor Activity; Ra | 1994 |
Effect of folate supplementation on clinical chemistry and hematologic changes related to bidisomide administration in the rat.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antidotes; Aspartate Am | 1995 |
Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status.
Topics: Animals; Biological Availability; Biomarkers; Body Weight; Liver; Male; Methylmalonic Acid; Rats; Ra | 2001 |
Ganglioside alterations in the central nervous system of rats chronically injected with methylmalonic and propionic acids.
Topics: Animals; Animals, Newborn; Body Weight; Central Nervous System; Cerebellum; Cerebral Cortex; Drug Ad | 2002 |
Dietary fiber and vitamin B12 balance.
Topics: Animals; Body Weight; Cellulose; Dietary Fiber; Feces; Intestinal Absorption; Methylmalonic Acid; Pe | 1979 |
Diminished concentration of the NF-H subunit of neurofilaments in cerebral cortex of rats chronically treated with proline, methylmalonate and phenylalanine plus alpha-methylphenylalanine.
Topics: Animals; Body Weight; Brain; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Methylmalonic Aci | 1992 |
Effect of cobalt deficiency in the pregnant ewe on reproductive performance and lamb viability.
Topics: Animals; Body Weight; Cobalt; Colostrum; Female; Fetal Death; Immunoglobulin G; Methylmalonic Acid; | 1991 |
Vitamin B-12 deficiency increases the specific activities of rat liver NADH- and NADPH-linked aquacobalamin reductase isozymes involved in coenzyme synthesis.
Topics: Animals; Body Weight; Coenzymes; Isoenzymes; Liver; Male; Methylmalonic Acid; NADH, NADPH Oxidoreduc | 1991 |
Evaluation of branched-chain amino acid intake in children with maple syrup urine disease and methylmalonic aciduria.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids, Branched-Chain; Ammonia; Body Weight; Child, Pres | 1990 |
Sequential changes in plasma methylmalonic acid and vitamin B12 in sheep eating cobalt-deficient grass.
Topics: Animals; Body Weight; Cobalt; Diet; Malonates; Methylmalonic Acid; Poaceae; Sheep; Vitamin B 12; Vit | 1989 |
Fermentable dietary fibers elevate urinary methylmalonate and decrease propionate oxidation in rats deprived of vitamin B-12.
Topics: Animals; Body Weight; Cellulose; Dietary Fiber; Fermentation; Intestines; Male; Malonates; Methylmal | 1989 |
Dietary pectin shortens the biologic half-life of vitamin B-12 in rats by increasing fecal and urinary losses.
Topics: Animals; Body Weight; Cobalt Radioisotopes; Dietary Fiber; Feces; Half-Life; Kidney; Liver; Male; Me | 1989 |
Methylmalonic acid in the diagnosis of cobalt deficiency in barley-fed lambs.
Topics: Animals; Body Weight; Cobalt; Diet; Female; Hordeum; Male; Malonates; Methylmalonic Acid; Sheep; Tim | 1989 |
Megadose effects of vitamin C on vitamin B-12 status in the rat.
Topics: Adrenal Glands; Animals; Ascorbic Acid; Body Weight; Coprophagia; Diet; Dose-Response Relationship, | 1989 |
Carnitine metabolism in the vitamin B-12-deficient rat.
Topics: Acetylcarnitine; Animals; Body Weight; Carnitine; Fasting; Male; Methylmalonic Acid; Rats; Vitamin B | 1988 |
Diminished concentrations of ganglioside N-acetylneuraminic acid (G-NeuAc) in cerebellum of young rats receiving chronic administration of methylmalonic acid.
Topics: Animals; Body Weight; Brain Chemistry; Cerebellum; DNA; Malonates; Methylmalonic Acid; Nerve Tissue | 1988 |
Organic aciduria in rats fed high amounts of xylitol or sorbitol.
Topics: Animals; Body Weight; Citrates; Citric Acid; Cytoplasm; Gas Chromatography-Mass Spectrometry; Hydrog | 1987 |
Alanine decreases the protein requirements of infants with inborn errors of amino acid metabolism.
Topics: Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Body Weight; Dietary Proteins; Female; H | 1985 |