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methylmalonic acid and Asymmetric Diabetic Proximal Motor Neuropathy

methylmalonic acid has been researched along with Asymmetric Diabetic Proximal Motor Neuropathy in 4 studies

Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.

Research Excerpts

ExcerptRelevanceReference
"Metformin-treated diabetics (MTD) showed a decrease in cobalamin, a rise in homocysteine, and methylmalonic acid, leading to accentuated diabetic peripheral neuropathy (DPN)."1.62The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus. ( El-Sherif, M; Esmael, A; Hashem, MM; Nassar, AK, 2021)
"The 176 Chinese patients with Type 2 diabetes mellitus were divided into 3 groups according to the levels of vitamin B12."1.40Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes. ( Chen, SH; Li, XB; Liu, XH; Liu, YT; Ni, YH; Sun, AL; Zhuang, XH, 2014)
"Metformin-treated patients had depressed Cbl levels and elevated fasting MMA and Hcy levels."1.36Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. ( Toth, C; Wile, DJ, 2010)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Hashem, MM1
Esmael, A1
Nassar, AK1
El-Sherif, M1
Sun, AL1
Ni, YH1
Li, XB1
Zhuang, XH1
Liu, YT1
Liu, XH1
Chen, SH1
Wile, DJ1
Toth, C1
WHITE, AM1
COX, EV1

Other Studies

4 other studies available for methylmalonic acid and Asymmetric Diabetic Proximal Motor Neuropathy

ArticleYear
The relationship between exacerbated diabetic peripheral neuropathy and metformin treatment in type 2 diabetes mellitus.
    Scientific reports, 2021, 01-21, Volume: 11, Issue:1

    Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Homocysteine; Humans; Male; Metformin; Met

2021
Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Adult; Aged; Asian People; Biomarkers; China; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Fema

2014
Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy.
    Diabetes care, 2010, Volume: 33, Issue:1

    Topics: Aged; Case-Control Studies; Chromatography, High Pressure Liquid; Diabetic Neuropathies; Electrophys

2010
METHYLMALONIC ACID EXCRETION AND VITAMIN B12 DEFICIENCY IN THE HUMAN.
    Annals of the New York Academy of Sciences, 1964, Apr-24, Volume: 112

    Topics: Anemia; Anemia, Macrocytic; Anemia, Pernicious; Carcinoma; Celiac Disease; Chromatography; Crohn Dis

1964