methylmalonic acid has been researched along with Anemia, Megaloblastic in 28 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Anemia, Megaloblastic: A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") with the cobalamin D variant of congenital methylmalonic aciduria-homocystinuria, whose previously reported lack of megaloblastic anemia conflicted with current concepts of cobalamin's role in DNA synthesis and the "methyltetrahydrofolate (MTHF) trap" hypothesis." | 7.66 | Abnormal deoxyuridine suppression test in congenital methylmalonic aciduria-homocystinuria without megaloblastic anemia: divergent biochemical and morphological bone marrow manifestations of disordered cobalamin metabolism in man. ( Carmel, R; Goodman, SI, 1982) |
| " He was found to have methylmalonic aciduria (79 mumol per milligram of creatinine) and homocystinuria (0." | 7.66 | A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian. ( Higginbottom, MC; Nyhan, WL; Sweetman, L, 1978) |
| " Characteristic features in such patients included paresthesia, sensory loss, ataxia, dementia, and psychiatric disorders; longstanding neurologic symptoms without anemia; normal white-cell and platelet counts and serum bilirubin and lactate dehydrogenase levels; and markedly elevated serum concentrations of methylmalonic acid and total homocysteine." | 3.67 | Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. ( Allen, RH; Brust, JC; Garrett, TJ; Healton, EB; Lindenbaum, J; Marcell, PD; Podell, ER; Savage, DG; Stabler, SP, 1988) |
| ") with the cobalamin D variant of congenital methylmalonic aciduria-homocystinuria, whose previously reported lack of megaloblastic anemia conflicted with current concepts of cobalamin's role in DNA synthesis and the "methyltetrahydrofolate (MTHF) trap" hypothesis." | 3.66 | Abnormal deoxyuridine suppression test in congenital methylmalonic aciduria-homocystinuria without megaloblastic anemia: divergent biochemical and morphological bone marrow manifestations of disordered cobalamin metabolism in man. ( Carmel, R; Goodman, SI, 1982) |
| " He was found to have methylmalonic aciduria (79 mumol per milligram of creatinine) and homocystinuria (0." | 3.66 | A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian. ( Higginbottom, MC; Nyhan, WL; Sweetman, L, 1978) |
| " The dosage of these two substances help to differenciate between both carencies, but it is not determinant of any of them and is an expensive method." | 1.30 | [Megaloblastic anemia: rapid and economical study]. ( Cicchetti, G; Marín, GH; Tentoni, J, 1997) |
| "Neurological dysfunction due to vitamin B12 deficiency is most prominent in patients with mild to moderate anaemia." | 1.29 | Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe. ( Bennie, A; Gangaidzo, I; Gwanzura, C; Kiire, C; Lindenbaum, J; Moyo, A; Mudenge, B; Mukiibi, JM; Savage, D; Sitima, J, 1994) |
| "Methylmalonic acid was assayed by converting it to propionate by heat decarboxylation and then measuring the propionate increment over the endogenous amount in the noncarboxylated sample." | 1.26 | Applicability of an enzymatic quantitation of methylmalonic, propionic, and acetic acids in normal and megaloblastic states. ( Frenkel, EP; Kitchens, RL, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (46.43) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 4 (14.29) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cora, MC | 1 |
| Gwinn, W | 1 |
| Wilson, R | 1 |
| King, D | 1 |
| Waidyanatha, S | 1 |
| Kissling, GE | 1 |
| Brar, SS | 1 |
| Olivera, D | 1 |
| Blystone, C | 1 |
| Travlos, G | 1 |
| Kook, PH | 2 |
| Reusch, CE | 1 |
| Hersberger, M | 2 |
| Kamoun, F | 1 |
| Guirat, R | 1 |
| Megdich, F | 1 |
| Ben Ameur, S | 1 |
| Kallel, C | 1 |
| Hachicha, M | 1 |
| Schiff, M | 1 |
| Ogier de Baulny, H | 1 |
| Bard, G | 1 |
| Barlogis, V | 1 |
| Hamel, C | 1 |
| Moat, SJ | 1 |
| Odent, S | 1 |
| Shortland, G | 1 |
| Touati, G | 1 |
| Giraudier, S | 1 |
| Watkins, D | 2 |
| Rosenblatt, DS | 2 |
| Ebara, S | 1 |
| Adachi, S | 1 |
| Takenaka, S | 1 |
| Enomoto, T | 1 |
| Watanabe, F | 1 |
| Yamaji, R | 1 |
| Inui, H | 1 |
| Nakano, Y | 1 |
| Carmel, R | 3 |
| Goodman, SI | 2 |
| Bedros, AA | 1 |
| Mace, JW | 1 |
| Savage, D | 1 |
| Gangaidzo, I | 1 |
| Lindenbaum, J | 3 |
| Kiire, C | 1 |
| Mukiibi, JM | 1 |
| Moyo, A | 1 |
| Gwanzura, C | 1 |
| Mudenge, B | 1 |
| Bennie, A | 1 |
| Sitima, J | 1 |
| Marín, GH | 1 |
| Tentoni, J | 1 |
| Cicchetti, G | 1 |
| Savage, DG | 2 |
| Ogundipe, A | 1 |
| Allen, RH | 2 |
| Stabler, SP | 2 |
| Kawakami, C | 1 |
| Tamai, H | 1 |
| Smolka, V | 1 |
| Bekárek, V | 1 |
| Hlídková, E | 1 |
| Bucil, J | 1 |
| Mayerová, D | 1 |
| Skopková, Z | 1 |
| Adam, T | 1 |
| Hrubá, E | 1 |
| Kozich, V | 1 |
| Buriánková, L | 1 |
| Saligová, J | 1 |
| Buncová, M | 1 |
| Zeman, J | 1 |
| Perri, GC | 1 |
| Higginbottom, MC | 1 |
| Sweetman, L | 1 |
| Nyhan, WL | 1 |
| Rosenberg, LE | 1 |
| Woolf, LI | 1 |
| Frenkel, EP | 1 |
| Kitchens, RL | 1 |
| Chanarin, I | 1 |
| Deacon, R | 1 |
| Lumb, M | 1 |
| Perry, J | 1 |
| Beck, WS | 1 |
| Sakamoto, S | 1 |
| Kondo, H | 1 |
| Kakinuma, H | 1 |
| Kanazawa, S | 1 |
| Iseki, T | 1 |
| Goto, S | 1 |
| Ohto, M | 1 |
| Yonemitsu, H | 1 |
| Okuda, K | 1 |
| Yamauchi, H | 1 |
| Omine, M | 1 |
| Tsukamoto, N | 1 |
| Katahira, H | 1 |
| Karasawa, M | 1 |
| Sugita, Y | 1 |
| Yatabe, H | 1 |
| Iwata, N | 1 |
| Maekawa, T | 1 |
| Tuchman, M | 1 |
| Kelly, P | 1 |
| Healton, EB | 1 |
| Brust, JC | 1 |
| Garrett, TJ | 1 |
| Podell, ER | 1 |
| Marcell, PD | 1 |
| Ho, CH | 1 |
| Chang, HC | 1 |
| Yeh, SF | 1 |
6 reviews available for methylmalonic acid and Anemia, Megaloblastic
| Article | Year |
|---|---|
[Methylmalonic acidemia].
Topics: Anemia, Megaloblastic; Diagnosis, Differential; Humans; Immune System Diseases; Metabolism, Inborn E | 2000 |
The laboratory diagnosis of megaloblastic anemias.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Antibodies; Clinical Laboratory Techniques; Erythrocytes; | 1978 |
Vitamin-responsive inherited metabolic disorders.
Topics: Adolescent; Adult; Anemia, Megaloblastic; Avitaminosis; Biological Transport; Biotin; Carrier Protei | 1976 |
The dietary treatment of inborn errors of metabolism.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Anemia, Megaloblastic; Child; Female; Folic Acid; | 1976 |
Cobalamin and folate: recent developments.
Topics: Anemia, Megaloblastic; Female; Folic Acid; Humans; Methylation; Methylmalonic Acid; Nervous System D | 1992 |
Diagnosis of megaloblastic anemia.
Topics: Anemia, Megaloblastic; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Deficiency | 1991 |
22 other studies available for methylmalonic acid and Anemia, Megaloblastic
| Article | Year |
|---|---|
A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice.
Topics: Anemia, Megaloblastic; Animals; Body Weight; Cimicifuga; Female; Folic Acid; Homocysteine; Kidney; L | 2017 |
Prospective long-term evaluation of parenteral hydroxocobalamin supplementation in juvenile beagles with selective intestinal cobalamin malabsorption (Imerslund-Gräsbeck syndrome).
Topics: Anemia, Megaloblastic; Animals; Creatinine; Dog Diseases; Dogs; Drug Administration Schedule; Female | 2018 |
Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund-Gräsbeck syndrome) maintains normal clinical and cellular cobalamin status.
Topics: Administration, Oral; Anemia, Megaloblastic; Animals; Dog Diseases; Dogs; Female; Malabsorption Synd | 2019 |
Frequent Infections, Hypotonia, and Anemia in a Breastfed Infant.
Topics: Adult; Agammaglobulinemia; Anemia, Megaloblastic; Anemia, Pernicious; Asymptomatic Diseases; Breast | 2017 |
Should transcobalamin deficiency be treated aggressively?
Topics: Anemia, Megaloblastic; Biological Transport; DNA Mutational Analysis; DNA Primers; Female; Homocyste | 2010 |
Inborn errors of cobalamin absorption and metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Anemia, Megaloblastic; Cobamides; Homocysteine; Humans; Hyperh | 2011 |
Hypoxia-induced megaloblastosis in vitamin B12-deficient rats.
Topics: Analysis of Variance; Anemia, Megaloblastic; Animals; Erythrocyte Count; Erythropoietin; Hypoxia; Ma | 2003 |
Abnormal deoxyuridine suppression test in congenital methylmalonic aciduria-homocystinuria without megaloblastic anemia: divergent biochemical and morphological bone marrow manifestations of disordered cobalamin metabolism in man.
Topics: Adolescent; Adult; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; Homocystinuria; Humans; Male; M | 1982 |
Congenital methylmalonic aciduria--homocystinuria with megaloblastic anemia: observations on response to hydroxocobalamin and on the effect of homocysteine and methionine on the deoxyuridine suppression test.
Topics: Anemia, Megaloblastic; Deoxyuridine; DNA; Female; Homocysteine; Homocystinuria; Humans; Hydroxocobal | 1980 |
Vitamin B12 deficiency is the primary cause of megaloblastic anaemia in Zimbabwe.
Topics: Anemia, Megaloblastic; Anemia, Pernicious; Erythrocyte Indices; Female; Folic Acid; Folic Acid Defic | 1994 |
[Megaloblastic anemia: rapid and economical study].
Topics: Adolescent; Adult; Algorithms; Anemia, Megaloblastic; Cost Control; Diagnosis, Differential; Diagnos | 1997 |
Etiology and diagnostic evaluation of macrocytosis.
Topics: Adult; Aged; Alcohol Drinking; Anemia, Macrocytic; Anemia, Megaloblastic; Bone Marrow Diseases; Diag | 2000 |
[Metabolic complications and neurologic manifestations of vitamin B12 deficiency in children of vegetarian mothers].
Topics: Anemia, Megaloblastic; Brain; Breast Feeding; Developmental Disabilities; Diet, Vegetarian; Failure | 2001 |
[Water-soluble vitamins in therapy: cobalamins].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Cobamides; Humans; Malonates; Metabolism, Inborn Errors; | 1977 |
A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12-deficient breast-fed infant of a strict vegetarian.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Anemia, Megaloblastic; Breast Feeding; Diagnosis, Diffe | 1978 |
Applicability of an enzymatic quantitation of methylmalonic, propionic, and acetic acids in normal and megaloblastic states.
Topics: Acetates; Anemia, Megaloblastic; Animals; Clinical Enzyme Tests; Folic Acid Deficiency; Humans; Malo | 1977 |
[Megaloblastic anemia].
Topics: Adult; Aged; Anemia, Megaloblastic; Bone Marrow; Deoxyuridine; DNA; Female; Folic Acid; Humans; Male | 1991 |
[Assessment of laboratory findings in megaloblastic anemia--measurement of serum vitamin B12 and methylmalonic acid].
Topics: Adult; Aged; Aged, 80 and over; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Male; Mal | 1989 |
[Urinary methylmalonic acid excretion and clinical features in megaloblastic anemia due to vitamin B12 deficiency].
Topics: Adolescent; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Humans; Male; Malonates; | 1989 |
Vitamin B12-responsive megaloblastic anemia, homocystinuria, and transient methylmalonic aciduria in cb1E disease.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Fibroblasts; Homocystinuria; Humans; Infant, Newborn; Mal | 1988 |
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.
Topics: Adolescent; Adult; Aged; Anemia; Anemia, Megaloblastic; Ataxia; Erythrocyte Indices; Erythrocytes; F | 1988 |
Quantitation of urinary methylmalonic acid by gas chromatography mass spectrometry and its clinical applications.
Topics: Aged; Anemia; Anemia, Megaloblastic; China; Humans; Malonates; Methylmalonic Acid; Middle Aged; Vita | 1987 |