methylmalonic acid has been researched along with Alzheimer Disease in 8 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20)." | 5.29 | Serum cobalamin and methylmalonic acid in Alzheimer dementia. ( Christensen, JE; Gulmann, NC; Kristensen, MO; Ostergaard, K; Rasmussen, K, 1993) |
| " The authors summarized dose-response evidence from randomized controlled trials and prospective cohort studies on the relation of vitamin B12 intake and status with cognitive function in adults and elderly people." | 2.49 | Vitamin B12 intake and status and cognitive function in elderly people. ( Brzozowska, A; Cavelaars, AE; de Groot, LC; Dhonukshe-Rutten, RA; Doets, EL; Dullemeijer, C; Souverein, OW; Szczecińska, A; van 't Veer, P; van Wijngaarden, JP, 2013) |
| "Evaluation for the diagnosis of Alzheimer's disease, routine laboratory tests, serum folate and vitamin B-12, serum methylmalonic acid (MMA), total homocysteine (tHcy), and radiological tests was performed in 52 patients with Alzheimer's disease (AD), 50 nondemented hospitalized controls, and 49 healthy elderly subjects living at home." | 1.30 | Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? ( Dejaeger, E; Dereymaeker, L; Ghekiere, V; Joosten, E; Lesaffre, E; Pelemans, W; Riezler, R, 1997) |
| "The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20)." | 1.29 | Serum cobalamin and methylmalonic acid in Alzheimer dementia. ( Christensen, JE; Gulmann, NC; Kristensen, MO; Ostergaard, K; Rasmussen, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hooshmand, B | 1 |
| Appold, F | 1 |
| Fissler, P | 1 |
| Perneczky, R | 1 |
| Otto, M | 1 |
| Tumani, H | 1 |
| Kivipelto, M | 1 |
| von Arnim, CAF | 1 |
| Oussalah, A | 1 |
| Levy, J | 1 |
| Filhine-Trésarrieu, P | 1 |
| Namour, F | 1 |
| Guéant, JL | 1 |
| Doets, EL | 1 |
| van Wijngaarden, JP | 1 |
| Szczecińska, A | 1 |
| Dullemeijer, C | 1 |
| Souverein, OW | 1 |
| Dhonukshe-Rutten, RA | 1 |
| Cavelaars, AE | 1 |
| van 't Veer, P | 1 |
| Brzozowska, A | 1 |
| de Groot, LC | 1 |
| Nilsson, K | 2 |
| Gustafson, L | 2 |
| Hultberg, B | 2 |
| Serot, JM | 1 |
| Barbé, F | 1 |
| Arning, E | 1 |
| Bottiglieri, T | 1 |
| Franck, P | 1 |
| Montagne, P | 1 |
| Nicolas, JP | 1 |
| Kristensen, MO | 1 |
| Gulmann, NC | 1 |
| Christensen, JE | 1 |
| Ostergaard, K | 1 |
| Rasmussen, K | 1 |
| Joosten, E | 1 |
| Lesaffre, E | 1 |
| Riezler, R | 1 |
| Ghekiere, V | 1 |
| Dereymaeker, L | 1 |
| Pelemans, W | 1 |
| Dejaeger, E | 1 |
| Warkentin, S | 1 |
| Fäldt, R | 1 |
2 reviews available for methylmalonic acid and Alzheimer Disease
| Article | Year |
|---|---|
Association of
Topics: Adult; Aged; Alleles; Alzheimer Disease; Carbon; Child; Congenital Abnormalities; Female; Genotype; | 2017 |
Vitamin B12 intake and status and cognitive function in elderly people.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cognition Disorders; Dementia; Diet; Humans; | 2013 |
6 other studies available for methylmalonic acid and Alzheimer Disease
| Article | Year |
|---|---|
Markers of Vitamin B12 Status in Relation to Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Cognitive Performance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognition; Cognitive Dysfunction; Humans; Meth | 2023 |
Optimal use of markers for cobalamin and folate status in a psychogeriatric population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognition Disorders; Female; Folic Acid; Hom | 2002 |
Homocysteine and methylmalonic acid concentrations in cerebrospinal fluid: relation with age and Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Female; Homocysteine; Humans; Male; Methylmalonic Acid; Middle Aged | 2005 |
Serum cobalamin and methylmalonic acid in Alzheimer dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Diagnosis, Differential; Erythrocyte In | 1993 |
Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease?
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Female; Folic Acid Deficiency; Homocysteine; Hosp | 1997 |
Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Circulation; Dementia, Vascular; Female; | 2000 |