methylmalonic acid has been researched along with Aging in 39 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We attempted to attribute associations that we previously found between higher folate status and anemia and cognitive test performance to circulating unmetabolized folic acid or 5-methyltetrahydrofolate (5MeTHF)." | 7.76 | Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2010) |
| "Hearing loss has been associated with poor vitamin B12 status in some, but not all studies." | 6.72 | Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults. ( Allen, RH; De Chicchis, AR; Johnson, MA; Park, S; Shea-Miller, K; Stabler, SP, 2006) |
| "Mandatory fortification of flour with folic acid has reduced the number of neural tube defects in North America." | 5.13 | Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial. ( Brouwer, IA; Clarke, R; Katan, MB; Verhoef, P; Winkels, RM, 2008) |
| "TC genotype and its associations with indicators of B12 status, including total B12, holotranscobalamin (holoTC), methylmalonic acid and homocysteine, were evaluated in a cohort of elderly Latinos (N=554, age 60-93 years) from the Sacramento Area Latino Study on Aging (SALSA)." | 3.76 | Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics. ( Allen, LH; Garrod, MG; Green, R; Haan, MN; Miller, JW, 2010) |
| "We attempted to attribute associations that we previously found between higher folate status and anemia and cognitive test performance to circulating unmetabolized folic acid or 5-methyltetrahydrofolate (5MeTHF)." | 3.76 | Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2010) |
| "Hearing loss has been associated with poor vitamin B12 status in some, but not all studies." | 2.72 | Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults. ( Allen, RH; De Chicchis, AR; Johnson, MA; Park, S; Shea-Miller, K; Stabler, SP, 2006) |
| " The use of these data to estimate dose-response relations provides a useful means to summarize the body of evidence." | 2.49 | Systematic review with dose-response meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned's prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elder ( Cavelaars, AE; de Boer, WJ; de Groot, LC; Dhonukshe-Rutten, RA; Doets, EL; Dullemeijer, C; In 't Veld, PH; Plada, M; Souverein, OW; van 't Veer, P; van der Voet, H; van Wijngaarden, JP, 2013) |
| " Finally, amnionless is a novel biomarker which can detect perturbed vitamin B12 bioavailability during aging and physical frailty." | 1.48 | Vitamin B12 deficiency and impaired expression of amnionless during aging. ( Bosco, N; De Castro, A; Feige, JN; Goulet, L; Karaz, S; Larbi, A; Michaud, J; Migliavacca, E; Ng, TP; Pannérec, A; Rezzi, S, 2018) |
| "Betaine was associated with the KOLT, TMT-A and COWAT, but after adjustments for potential confounders, the associations lost significance." | 1.39 | Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. ( Bjelland, I; Drevon, CA; Engedal, K; Nurk, E; Nygaard, HA; Refsum, H; Smith, DA; Tell, GS; Ueland, PM; Vollset, SE, 2013) |
| "Previous reports on pernicious anemia treatment suggested that high folic acid intake adversely influences the natural history of vitamin B-12 deficiency, which affects many elderly individuals." | 1.35 | Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. ( Jacques, PF; Morris, MS; Rosenberg, IH; Selhub, J, 2009) |
| "HoloTC was the earliest marker for vitamin B12 deficiency followed by MMA." | 1.32 | Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk. ( Geisel, J; Herrmann, W; Obeid, R; Schorr, H, 2003) |
| " Food folate intake had an inverse dose-response relation with tHcy that was limited to nonusers of supplements." | 1.31 | Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use. ( Allen, RH; Baumgartner, RN; Garry, PJ; Koehler, KM; Rimm, EB; Stabler, SP, 2001) |
| "Evaluation for the diagnosis of Alzheimer's disease, routine laboratory tests, serum folate and vitamin B-12, serum methylmalonic acid (MMA), total homocysteine (tHcy), and radiological tests was performed in 52 patients with Alzheimer's disease (AD), 50 nondemented hospitalized controls, and 49 healthy elderly subjects living at home." | 1.30 | Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? ( Dejaeger, E; Dereymaeker, L; Ghekiere, V; Joosten, E; Lesaffre, E; Pelemans, W; Riezler, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (20.51) | 18.2507 |
| 2000's | 17 (43.59) | 29.6817 |
| 2010's | 10 (25.64) | 24.3611 |
| 2020's | 4 (10.26) | 2.80 |
| Authors | Studies |
|---|---|
| Djouadi, F | 1 |
| Mouillet-Richard, S | 1 |
| Gomes, AP | 1 |
| Ilter, D | 1 |
| Low, V | 1 |
| Endress, JE | 1 |
| Fernández-García, J | 1 |
| Rosenzweig, A | 1 |
| Schild, T | 1 |
| Broekaert, D | 1 |
| Ahmed, A | 1 |
| Planque, M | 1 |
| Elia, I | 1 |
| Han, J | 1 |
| Kinzig, C | 1 |
| Mullarky, E | 1 |
| Mutvei, AP | 1 |
| Asara, J | 1 |
| de Cabo, R | 1 |
| Cantley, LC | 1 |
| Dephoure, N | 1 |
| Fendt, SM | 1 |
| Blenis, J | 1 |
| Wang, H | 1 |
| Zhang, XH | 1 |
| Harjes, U | 1 |
| Pannérec, A | 1 |
| Migliavacca, E | 1 |
| De Castro, A | 1 |
| Michaud, J | 1 |
| Karaz, S | 1 |
| Goulet, L | 1 |
| Rezzi, S | 1 |
| Ng, TP | 1 |
| Bosco, N | 1 |
| Larbi, A | 1 |
| Feige, JN | 1 |
| Solomon, LR | 1 |
| Risch, M | 1 |
| Meier, DW | 1 |
| Sakem, B | 1 |
| Medina Escobar, P | 1 |
| Risch, C | 1 |
| Nydegger, U | 1 |
| Risch, L | 1 |
| Winkels, RM | 1 |
| Brouwer, IA | 1 |
| Clarke, R | 1 |
| Katan, MB | 1 |
| Verhoef, P | 1 |
| Smith, AD | 1 |
| Refsum, H | 2 |
| Selhub, J | 3 |
| Morris, MS | 3 |
| Jacques, PF | 3 |
| Rosenberg, IH | 4 |
| Garrod, MG | 1 |
| Allen, LH | 1 |
| Haan, MN | 1 |
| Green, R | 2 |
| Miller, JW | 1 |
| Chatthanawaree, W | 1 |
| Nurk, E | 1 |
| Bjelland, I | 1 |
| Drevon, CA | 1 |
| Tell, GS | 1 |
| Ueland, PM | 1 |
| Vollset, SE | 1 |
| Engedal, K | 1 |
| Nygaard, HA | 1 |
| Smith, DA | 1 |
| McCaddon, A | 2 |
| Hill, MH | 1 |
| Flatley, JE | 1 |
| Barker, ME | 1 |
| Garner, CM | 1 |
| Manning, NJ | 1 |
| Olpin, SE | 1 |
| Moat, SJ | 1 |
| Russell, J | 1 |
| Powers, HJ | 1 |
| Dullemeijer, C | 1 |
| Souverein, OW | 1 |
| Doets, EL | 1 |
| van der Voet, H | 1 |
| van Wijngaarden, JP | 1 |
| de Boer, WJ | 1 |
| Plada, M | 1 |
| Dhonukshe-Rutten, RA | 1 |
| In 't Veld, PH | 1 |
| Cavelaars, AE | 1 |
| de Groot, LC | 1 |
| van 't Veer, P | 1 |
| Hultberg, B | 1 |
| Nilsson, K | 1 |
| Isaksson, A | 1 |
| Gustafson, L | 1 |
| Kölker, S | 1 |
| Schwab, M | 1 |
| Hörster, F | 1 |
| Sauer, S | 1 |
| Hinz, A | 1 |
| Wolf, NI | 1 |
| Mayatepek, E | 1 |
| Hoffmann, GF | 1 |
| Smeitink, JA | 1 |
| Okun, JG | 1 |
| Herrmann, W | 2 |
| Obeid, R | 2 |
| Schorr, H | 1 |
| Geisel, J | 1 |
| Kwok, T | 1 |
| Cheng, G | 1 |
| Lai, WK | 1 |
| Poon, P | 1 |
| Woo, J | 1 |
| Pang, CP | 1 |
| McCracken, C | 1 |
| Hudson, P | 1 |
| Ellis, R | 1 |
| Kostopoulos, P | 1 |
| Knapp, JP | 1 |
| Kasoha, M | 1 |
| Becker, G | 1 |
| Fassbender, K | 1 |
| Barbosa, PR | 1 |
| Stabler, SP | 5 |
| Trentin, R | 1 |
| Carvalho, FR | 1 |
| Luchessi, AD | 1 |
| Hirata, RD | 1 |
| Hirata, MH | 1 |
| Allen, RH | 4 |
| Guerra-Shinohara, EM | 1 |
| Park, S | 1 |
| Johnson, MA | 1 |
| Shea-Miller, K | 1 |
| De Chicchis, AR | 1 |
| Hogeveen, M | 1 |
| van Beynum, I | 1 |
| van Rooij, A | 1 |
| Kluijtmans, L | 1 |
| den Heijer, M | 1 |
| Blom, H | 1 |
| Lindenbaum, J | 1 |
| Wilson, PW | 1 |
| Rasmussen, K | 1 |
| Møller, J | 1 |
| Lyngbak, M | 1 |
| Pedersen, AM | 1 |
| Dybkjaer, L | 1 |
| Joosten, E | 2 |
| Lesaffre, E | 2 |
| Riezler, R | 2 |
| Carmel, R | 1 |
| Howard, JM | 1 |
| Jacobsen, DW | 1 |
| Azen, C | 1 |
| Ghekiere, V | 1 |
| Dereymaeker, L | 1 |
| Pelemans, W | 1 |
| Dejaeger, E | 1 |
| Bächli, E | 1 |
| Fehr, J | 1 |
| Augoustides-Savvopoulou, P | 1 |
| Mylonas, I | 1 |
| Sewell, AC | 1 |
| Rosenblatt, DS | 1 |
| Wyse, AT | 1 |
| Streck, EL | 1 |
| Barros, SV | 1 |
| Brusque, AM | 1 |
| Zugno, AI | 1 |
| Wajner, M | 1 |
| Koehler, KM | 1 |
| Baumgartner, RN | 1 |
| Garry, PJ | 1 |
| Rimm, EB | 1 |
| van Asselt, DZ | 1 |
| Pasman, JW | 1 |
| van Lier, HJ | 1 |
| Vingerhoets, DM | 1 |
| Poels, PJ | 1 |
| Kuin, Y | 1 |
| Blom, HJ | 1 |
| Hoefnagels, WH | 1 |
| Miller, DR | 1 |
| Specker, BL | 1 |
| Ho, ML | 1 |
| Norman, EJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Bread Trial: a Demonstration Trial to Show Effects of Fortification of Food With Both Folic Acid and Vitamin B12[NCT00353353] | 150 participants (Anticipated) | Interventional | 2006-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for methylmalonic acid and Aging
| Article | Year |
|---|---|
Vitamin B-12 and cognition in the elderly.
Topics: Aged; Aging; Biomarkers; Cognition Disorders; Female; Humans; Male; Methylmalonic Acid; Nutritional | 2009 |
Biomarkers of cobalamin (vitamin B12) deficiency and its application.
Topics: Aging; Biomarkers; Cognition Disorders; Erythrocyte Indices; Female; Homocysteine; Humans; Male; Met | 2011 |
Vitamin B12 in neurology and ageing; clinical and genetic aspects.
Topics: Aging; Humans; Methylmalonic Acid; Neurology; Vitamin B 12; Vitamin B 12 Deficiency | 2013 |
Systematic review with dose-response meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned's prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elder
Topics: Adult; Aged; Aging; Biomarkers; European Union; Evidence-Based Medicine; Humans; Methylmalonic Acid; | 2013 |
[Diagnosis of vitamin B12 deficiency: only apparently child's play].
Topics: Aging; Anemia, Pernicious; Blood Cell Count; Diagnosis, Differential; Folic Acid Deficiency; Gastrit | 1999 |
4 trials available for methylmalonic acid and Aging
| Article | Year |
|---|---|
Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial.
Topics: Aged; Aging; Bread; Double-Blind Method; Erythrocytes; Female; Folic Acid; Food, Fortified; Homocyst | 2008 |
A vitamin B-12 supplement of 500 μg/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status.
Topics: Aged; Aged, 80 and over; Aging; Apoproteins; Biomarkers; Creatinine; Cross-Sectional Studies; Dietar | 2013 |
Age-related hearing loss, methylmalonic acid, and vitamin B12 status in older adults.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Cohort Studies; Creatinine; Dietary Supplements; Dose-R | 2006 |
Cobalamin supplementation improves cognitive and cerebral function in older, cobalamin-deficient persons.
Topics: Aged; Aged, 80 and over; Aging; Brain; Cognition; Electroencephalography; Female; Humans; Hydroxocob | 2001 |
30 other studies available for methylmalonic acid and Aging
| Article | Year |
|---|---|
[Methylmalonic acid: A new link between ageing and tumour progression].
Topics: Aging; Humans; Methylmalonic Acid; Neoplastic Processes | 2021 |
Age-induced accumulation of methylmalonic acid promotes tumour progression.
Topics: Adult; Aged; Aging; Animals; Cell Line, Tumor; Disease Progression; Female; Gene Expression Regulati | 2020 |
Molecules in the blood of older people promote cancer spread.
Topics: Aged; Aged, 80 and over; Aging; Humans; Methylmalonic Acid; Neoplasms | 2020 |
Metabolic ageing drives tumour progression.
Topics: Aging; Humans; Methylmalonic Acid; Neoplastic Processes | 2020 |
Vitamin B12 deficiency and impaired expression of amnionless during aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Animals; Biomarkers; Female; Humans; Longitudinal Studies; Ma | 2018 |
Functional cobalamin (vitamin B12) deficiency: role of advanced age and disorders associated with increased oxidative stress.
Topics: Aged; Aged, 80 and over; Aging; Alcohol Drinking; Connecticut; Diabetes Mellitus; Dietary Supplement | 2015 |
Vitamin B12 and folate levels in healthy Swiss senior citizens: a prospective study evaluating reference intervals and decision limits.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Biomarkers; Erythrocyte Count; Female; Folic Acid; Homo | 2015 |
Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aging; Anemia, Pernicious; Cognition Diso | 2009 |
Transcobalamin C776G genotype modifies the association between vitamin B12 and homocysteine in older Hispanics.
Topics: Aged; Aging; Analysis of Variance; California; Female; Genotype; Health Surveys; Hispanic or Latino; | 2010 |
Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors.
Topics: Aged; Aging; Anemia; Anemia, Macrocytic; Blood Cell Count; Cognition; Cognition Disorders; Cystatin | 2010 |
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study.
Topics: Aged; Aging; Betaine; Biomarkers; Choline; Choline Deficiency; Cognitive Dysfunction; Cohort Studies | 2013 |
Elevated serum methylmalonic acid concentrations are common among elderly Americans.
Topics: Adult; Aged; Aging; Black or African American; Creatinine; Female; Folic Acid; Hispanic or Latino; H | 2002 |
Folate deficiency is a common finding in psychogeriatric patients.
Topics: Aged; Aged, 80 and over; Aging; Cognition Disorders; Female; Folic Acid; Folic Acid Deficiency; Homo | 2002 |
Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain.
Topics: Acyl Coenzyme A; Adenosine Triphosphate; Aging; Amino Acid Metabolism, Inborn Errors; Animals; Cattl | 2003 |
Functional vitamin B12 deficiency and determination of holotranscobalamin in populations at risk.
Topics: Adult; Aged; Aged, 80 and over; Aging; Biomarkers; Diet, Vegetarian; Female; Folic Acid; Germany; Ho | 2003 |
Use of fasting urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older persons.
Topics: Aging; Biomarkers; Creatinine; Diet, Vegetarian; Fasting; Female; Folic Acid; Hong Kong; Humans; Kid | 2004 |
Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Ageing Study.
Topics: Aged; Aged, 80 and over; Aging; Cognition; Cohort Studies; Cross-Sectional Studies; Female; Folic Ac | 2006 |
Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid.
Topics: Adult; Aged; Aging; Biomarkers; Cystathionine; Female; Folic Acid; Homocysteine; Humans; Male; Methy | 2007 |
Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women.
Topics: Adult; Aging; Alleles; Anemia, Iron-Deficiency; Avitaminosis; Brazil; Female; Genotype; Homocysteine | 2008 |
Methylmalonic acid values in healthy Dutch children.
Topics: Adolescent; Adult; Aging; Biomarkers; Child; Child, Preschool; Creatinine; Cross-Sectional Studies; | 2008 |
Prevalence of cobalamin deficiency in the Framingham elderly population.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cohort Studies; Female; Folic Acid Deficiency; Gas Chromatogr | 1994 |
Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation.
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic | 1996 |
Are different reference intervals for methylmalonic acid and total homocysteine necessary in elderly people?
Topics: Adult; Aged; Aged, 80 and over; Aging; Female; Folic Acid; Homocysteine; Humans; Male; Methylmalonic | 1996 |
Hormone replacement therapy and cobalamin status in elderly women.
Topics: Aged; Aging; Cohort Studies; Estrogen Replacement Therapy; Female; Homocysteine; Humans; Methylmalon | 1996 |
Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease?
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Female; Folic Acid Deficiency; Homocysteine; Hosp | 1997 |
Reversible dementia in an adolescent with cblC disease: clinical heterogeneity within the same family.
Topics: Aging; Child; Dementia; Electroencephalography; Female; Homocystinuria; Humans; Hydroxocobalamin; Le | 1999 |
Using homocysteine and related metabolites to diagnose vitamin deficiency states.
Topics: Aging; Animals; Folic Acid Deficiency; Homocysteine; Humans; Methylmalonic Acid; Vitamin B 12 Defici | 2000 |
Methylmalonate administration decreases Na+,K+-ATPase activity in cerebral cortex of rats.
Topics: Aging; Animals; Ca(2+) Mg(2+)-ATPase; Cell Membrane; Cerebral Cortex; Glutathione; Methylmalonic Aci | 2000 |
Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Coffee; Cross-Sectional Studies; Diet | 2001 |
Vitamin B-12 status in a macrobiotic community.
Topics: Adult; Aged; Aging; Animals; Child; Child, Preschool; Dairy Products; Diet, Macrobiotic; Eggs; Femal | 1991 |