methylmalonic acid has been researched along with Acute Kidney Injury in 7 studies
Methylmalonic Acid: A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA.
methylmalonic acid : A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " CblC deficiency, an inborn error of cobalamin processing, is a rare cause of atypical hemolytic-uremic syndrome (aHUS) and results in hyperhomocysteinemia and methylmalonic aciduria." | 8.12 | The roles of homocysteinemia and methylmalonic acidemia in kidney injury in atypical hemolytic uremic syndrome caused by cobalamin C deficiency. ( Elmaghrabi, A; Gotway, G; Wolf, MTF; Wood, WD, 2022) |
| " CblC deficiency, an inborn error of cobalamin processing, is a rare cause of atypical hemolytic-uremic syndrome (aHUS) and results in hyperhomocysteinemia and methylmalonic aciduria." | 4.12 | The roles of homocysteinemia and methylmalonic acidemia in kidney injury in atypical hemolytic uremic syndrome caused by cobalamin C deficiency. ( Elmaghrabi, A; Gotway, G; Wolf, MTF; Wood, WD, 2022) |
| "Methylmalonic acidemia (MMA) is an autosomal recessive disease of organic acidemia." | 1.48 | Management of adult-onset methylmalonic acidemia with hypotonia and acute respiratory failure: A case report. ( Chang, HT; Chang, MY; Chu, CC; Hsu, YL; Zhao, Z, 2018) |
| "The influence of acute renal failure induced by gentamicin administration on the effects of MMA on mitochondrial respiratory chain complexes, citrate synthase, succinate dehydrogenase and creatine kinase activities in cerebral cortex and kidney of young rats were investigated." | 1.39 | Acute renal failure potentiates brain energy dysfunction elicited by methylmalonic acid. ( Ferreira, GC; Januário, SB; Mafioleti, RL; Malgarin, F; Pettenuzzo, LF; Scaini, G; Schuck, PF; Simon, KR; Streck, EL, 2013) |
| "Acute renal failure was induced by gentamicin, an aminoglycoside antibiotic whose utilization over prolonged periods causes nephrotoxicity." | 1.39 | Acute renal failure potentiates methylmalonate-induced oxidative stress in brain and kidney of rats. ( Alves, L; Dal-Pizzol, F; Felisberto, F; Ferreira, GC; Freitas, BW; Petronilho, F; Pettenuzzo, LF; Rodrigues, LB; Schuck, PF; Streck, EL, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Wood, WD | 1 |
| Elmaghrabi, A | 1 |
| Gotway, G | 1 |
| Wolf, MTF | 1 |
| Zhao, Z | 1 |
| Chu, CC | 1 |
| Chang, MY | 1 |
| Chang, HT | 1 |
| Hsu, YL | 1 |
| Schuck, PF | 2 |
| Januário, SB | 1 |
| Simon, KR | 1 |
| Scaini, G | 1 |
| Mafioleti, RL | 1 |
| Malgarin, F | 1 |
| Pettenuzzo, LF | 2 |
| Streck, EL | 2 |
| Ferreira, GC | 2 |
| Alves, L | 1 |
| Felisberto, F | 1 |
| Rodrigues, LB | 1 |
| Freitas, BW | 1 |
| Petronilho, F | 1 |
| Dal-Pizzol, F | 1 |
| Nyhan, WL | 1 |
| Gargus, JJ | 1 |
| Boyle, K | 1 |
| Selby, R | 1 |
| Koch, R | 1 |
| Sharma, AP | 1 |
| Greenberg, CR | 1 |
| Prasad, AN | 1 |
| Prasad, C | 1 |
| Royer, P | 1 |
7 other studies available for methylmalonic acid and Acute Kidney Injury
| Article | Year |
|---|---|
The roles of homocysteinemia and methylmalonic acidemia in kidney injury in atypical hemolytic uremic syndrome caused by cobalamin C deficiency.
Topics: Acute Kidney Injury; Amino Acid Metabolism, Inborn Errors; Atypical Hemolytic Uremic Syndrome; Femal | 2022 |
Management of adult-onset methylmalonic acidemia with hypotonia and acute respiratory failure: A case report.
Topics: Acute Kidney Injury; Adult; Amino Acid Metabolism, Inborn Errors; Diagnosis, Differential; Electric | 2018 |
Acute renal failure potentiates brain energy dysfunction elicited by methylmalonic acid.
Topics: Acute Kidney Injury; Animals; Brain; Brain Diseases, Metabolic; Dose-Response Relationship, Drug; Dr | 2013 |
Acute renal failure potentiates methylmalonate-induced oxidative stress in brain and kidney of rats.
Topics: Acute Kidney Injury; Amino Acid Metabolism, Inborn Errors; Animals; Catalase; Cerebral Cortex; Creat | 2013 |
Progressive neurologic disability in methylmalonic acidemia despite transplantation of the liver.
Topics: Acute Kidney Injury; Adult; Disease Progression; Female; Humans; Liver Transplantation; Metabolism, | 2002 |
Hemolytic uremic syndrome (HUS) secondary to cobalamin C (cblC) disorder.
Topics: Acute Kidney Injury; Betaine; Brain Diseases, Metabolic, Inborn; Carnitine; Carrier Proteins; Combin | 2007 |
Hyperuricemia in children, with the exception of the Lesch-Nyhan syndrome.
Topics: Acidosis; Acute Disease; Acute Kidney Injury; Adult; Child; Child, Preschool; Chronic Disease; Femal | 1974 |